Bio Do Now
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Transcript of Bio Do Now
Bio Do Now
• Do you have the same DNA as the person sitting next to you?
• How can you tell?
• Get out your notes
mutation
• Any change in the nucleotide-base sequence of a gene/DNA molecule
• Either on chromosome level or nucleotide level
• Germ cell mutation- occurs in gamete (egg or sperm) affects offspring
• Somatic cell mutation- occurs in body cell, affects individual
Gene Mutations• Point mutations- substitution of a single
nucleotide
• Frameshift- insertion or deletion of a nucleotide
• Original DNA:• DNA: TAC CTA CTC GAG TAG• mRNA: AUG GAU GAG CUC AUC• tRNA: UAC CUA CUC GAG UAG• Start: She ate ham stop• Mutation 1:• DNA: TAC CTA CTC GAC TAG• mRNA: AUG GAU GAC CUG AUC• tRNA: UAC CUA CUG GAC UAG• Start: She ate Sam stop
• Original DNA:• DNA: TAC CTA CTC GAG TAG ACT…• mRNA: AUG GAU GAG CUC AUC• tRNA: UAC CUA CUC GAG UAG• Start: She ate ham stop• Mutation 2:• DNA: TAC CAC TCG AGT AGA CT…• mRNA: AUG GUG AGC UCA UCA GA• tRNA: UAC CAC UCG AGU AGU CU• Start: hea the ama ndw asn ots ad…
• Come up with your own three letter word sentence.
• Model a point mutation
• Model a frameshift
• Which is more likely to have an effect on a protein, a point mutation or a frameshift mutation?
Chromosome mutations
Car analogy
Chromosome mutations
• Deletion- loss of part of a chromosome
Chromosome mutations
• Duplication- gene on a chromosome is copied twice
Chromosome mutations
• Inversion- part of chromosome breaks, flips around backwards, and reattaches
Chromosome mutations
• Translocation- piece of chromosome breaks off and attaches to another chromosome
Chromosome mutations
• Non-disjunction- chromosome fails to separate during meiosis, one gamete receives 2 copies, the other none
Mutations can be:
1) harmful- lethal or detrimental to growth and development
2) beneficial- give evolutionary advantage
3)neutral- no change in gene expression or protein structure
For each of the following:• Transcribe into RNA and find the amino acid
sequence that it codes for (table p.244)
• Determine what type of gene mutation has occurred
Original: TAC CTA GAA CCG ATC
Mutation 1: TAC CTA GAA CCA ATC
Mutation 2: TAC CTA GAT ACC GAT C
Mutation 3: TAC CTA AAC CGA TC
Mutation 4: TAC CTT GAA CCG ATC
Read about mutagens
• p.255