Bio 328 Immunology Immunodeficiencies.
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Transcript of Bio 328 Immunology Immunodeficiencies.
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Bio 328 Immunology
Immunodeficiencies
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PHAGOCYTE DEFICIENCIES:
- Chronic Granulomatous Disease
- G6PD-deficiencies
- Chediak-Higashi syndrome
- Leukocyte adhesion deficiency
- Neutrophil specific granule Deficiency
- Myeloperoxidase deficiency
- Lazy leukocyte syndrome
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Chronic Granulomatous Disease
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Chronic Granulomatous Disease
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Chronic Granulomatous Disease
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NBT reduction test
gp91
Diagnosis of X-linked Chronic Granulomatous Disease.
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David Phillip Vetter (September 21, 1971 – February 22, 1984)
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Non-Obese Diabetic mice and BB rats prone to develop spontaneous, autoimmune (type I) diabetes: Treg deficiency.
ALPS, Autoimmune Lymphoproliferative SyndromeFas deficiency
APECED, Autoimmune polyendocrinopathy-candiadiasis-ectodermal dystrophy
AIRE deficiency
IPEX, Immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (Scurfy)
Foxp3 deficiency
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Immune dysregulation in humansubjects with heterozygous germline
mutations in CTLA4
Hye Sun Kuehn,1* Weiming Ouyang,2* Bernice Lo,3,4* Elissa K. Deenick,5,6 Julie E. Niemela,1 Danielle T. Avery,5 Jean-Nicolas Schickel,7 Dat Q. Tran,8 Jennifer Stoddard,1 Yu Zhang,4,9 DavidM. Frucht,2 Bogdan
Dumitriu,10 Phillip Scheinberg,10 Les R. Folio,11 Cathleen A. Frein,12Susan Price,3,4 Christopher Koh,13 Theo Heller,13 ChristineM.
Seroogy,14 Anna Huttenlocher,14,15 V. Koneti Rao,3,4 Helen C. Su,4,9 David Kleiner,16 Luigi D. Notarangelo,17 Yajesh Rampertaap,18
Kenneth N. Olivier,18 Joshua McElwee,19 Jason Hughes,19 Stefania Pittaluga,16 Joao B. Oliveira,20 Eric Meffre,7 Thomas A. Fleisher,1† Steven M. Holland,4,18 Michael J. Lenardo,3,4† Stuart G. Tangye,5,6
Gulbu Uzel18†
Science 26 September 2014, vol 345 p1623.
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The End