Dec 7, 2003

Poster

Prediction of Half Activation Voltages of Voltage-gated Potassium Channels Based on Amino Acid

Sequences Using Machine Learning

Bin Li and Warren J. GallinDepartment of Biological Sciences

University of Alberta Edmonton, Canada

Dec 7, 2003

Poster

Basic Learning

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Filter

Training data:58 VKC sequences -296 residues (features) eachClass: published Va values

Outlier Selection

ComparisonMatrix

KNN classifier

http://vkcdb.biology.ualberta.ca

Data Processing

Training set Construction of classifier

VKC

Dec 7, 2003

Poster

Mathematics Biology?

KNN classifier

Feature selection

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BLOSUM62

Outlier selection

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Q/E

R/K

A/S/V

Machine learning may not provide definitive answers to biological problems,but it help propose newhypotheses for experimentaltests.