Slide 1

CH3-(CH2)12-CH2-CH2-COOH (Palmitic acid )CoASH H2O

Palmityl CoA synthetase

ATPAMP+2Pi

CH3-(CH2)12-CH2-CH2 CO-SCoA (Palmityl CoA )

CarnitineCoASHCAT I Inner mitochondrial membraneCH3-(CH2)12-CH2-CH2-CO-carnitine (palmityl carnitine)

CH3-(CH2)12-CH2-CH2 CO-SCoA (Palmityl CoA ) CoASHCarnitine

CAT IICH3-(CH2)12-CH2-CH2 CO-SCoA (Palmityl CoA )

FADFADH2Palmityl CoA dehydrogenase CH3-(CH2)12-CH=CHCO-SCoA (Enoyl CoA)

H2OEnoyl CoA hydratase CH3-(CH2)12-CHOH-CH2CO-SCoA

(-hydroxyacyl-CoA)

NADNADH+H-hydroxyacyl-CoA dehydrogenase CH3-(CH2)12-CO-CH2-CO-SCoA

(-ketoacyl-CoA)

ThiolaseCoASH CH3-(CH2)12-CO-SCoA + CH3-CO-SCoA (Myristoyl CoA) (Acetyl CoA) -oxidation of fatty acids palmitic acid

NB: Carnitine(CH3)3-N-CH2-CHOH-CH2-COOH

Activation of F.AMain reaction