Endocrine Endocrine SystemSystem

Harliansyah,Ph.DHarliansyah,Ph.D

Dept Biochemistry, FK-UYDept Biochemistry, FK-UY

Chemical Communication Chemical Communication SystemSystem

Endocrine System:

Function; secreting secreting hormoneshormones which regulate the which regulate the functions of the body and maintenance of functions of the body and maintenance of a steady internal environment statea steady internal environment state

Hormones are chemical substances, involved in cell-to-cell communication, thatpromote the maintenance of homeostasis.

Hormones are blood borne substances involved in regulating a variety of process.

Hormone (derived from the Greek hormaein, which means to “excite” or to “stir up”

The endocrine system forms an important communication system that serves toRegulate, Integrate and Coordinate a variety of different physiological process.

The processes that hormone regulate fall in to four areas:

1. The digestion, utilization and storage of nutrient2. Growth and development3. Ion and water balance4. Reproductive function

The Classical hormones fall into three categories:

•Derivatives of the amino acid tyrosine•Steroids, which are derivatives of cholesterol•Peptides, proteins which comprise the largest and most diverse class of hormones

Mechanisms of hormone Mechanisms of hormone actionaction

THE GROWTH HORMONE CONTROL SYSTEM

The same hormone may have The same hormone may have different effects on target cells that different effects on target cells that havehave Different receptors for the hormoneDifferent receptors for the hormone Different signal transduction pathwaysDifferent signal transduction pathways Different proteins for carrying out the Different proteins for carrying out the

responseresponse

Certain endocrine Certain endocrine diseasedisease

Diabetes mellitusDiabetes mellitus Thyroid disordersThyroid disorders Reproductive disorderReproductive disorder