Bello US-China Workshop 2009
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Transcript of Bello US-China Workshop 2009
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Developing SustainableNanomanufacturing
Dhimiter Bello, ScD., MScDept. Work Environment, University of
Massachusetts Lowell& The Center for High Rate
Nanomanufacturing
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Sustainable Production can be defined asthe creation of goods and servicesusing processes and systems that are:Non-polluting; Conserving of energy
and natural resources; Economicallyviable; Safe and healthful for workers,communities, and consumers; Sociallyand creatively rewarding for all workingpeople.
Lowell Center for Sustainable Production,http://www.sustainableproduction.org/abou.what.shtml ,September 3, 2009.
http://www.sustainableproduction.org/abou.what.shtmlhttp://www.sustainableproduction.org/abou.what.shtml -
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lide Courtesy of. . ,rof R Herrickarvard School ofublic Health
I wish to acknowledge receipt of yourOctober 1stenclosing copy of theSeptember 25thletter from the editor of
.ASBESTOS quite agree with youhat our interests are best servedy having asbestosis receive the.i nim um o f p ub li ci ty
eminder
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Lessons from the past
Harremos P, Gee D, Macgarvin M, Stirling A, Keys J, Wynne B,et al. 2001. Late lessons from early warnings: theprecautionary principle 1896-2000. Environmental IssueReport, No 22. Copenhagen: European Environmental Agency.
We are in danger of repeating old, potentially costly,mistakes.
Hansen SF, Maynard A, Baun A, Tickner JA. 2008. Late lessons fromearly warnings for nanotechnology. Nat Nanotechnol 3(8): 444-447.
Royal Society and Royal Academy of Engineering,
Nanoscience and nanotechnologies: opportunities anduncertainties, July 29, 2004,http://www.nanotec.org.uk/finalReport.htm.
Provided a roadmap for responsible development ofnanotechnology
The Responsible Nano Forum. 2009. A beacon or just a
http://www.nanotec.org.uk/finalReport.htmhttp://www.nanotec.org.uk/finalReport.htm -
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5
: ,h ru st 3 Te stb e d sp p licatio n s a n dR e lia b ility
; ;EU UML UNH
:hrust 1 anoelements andanotemplates; ;EU UML UNH
:hrust 2-igh ratessembly and Transfer; ;EU UML UNH
CHN Path toNanomanufacturing
- -End of Life Impacts
-High rate ToxicityScreening
Environmental andEconomic Uncertainties
Exposure Assessment& Control
Regulatory Issues
&Social Ethical Issues
Slide courtesy of, .Isaacs J
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Toxicity ScreeningBiological SignificanceBetter Exposure Metrics
Are there Exposures?
Are they Hazardous?
How to best avoid them?
AXIMIZE echnological,enefits whileINIMIZING Health!ISKS
NANOMANUFACTURING
HumanHealth and the Environment
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Broader Context: Safety ~1/Risk
Health Risk = f(EXPOSURE, TOXICITY,
EPIGENETIC &
NUTRITIONAL, TIME)
EXPOSURE TOXICITY
EPIGENETIC&NUTRITIONAL
.1 Exposures as important asToxicity
.2 We can act upon exposuresin face of other
uncertainties.3 Toxicity is strongly
influenced by materialtype
.4 Limited options on
epigenetic factors
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Changes are difficult tomake
Approximate ratio of publications onSynthesis & Applications : Toxicity:
Exposures
>1000 : 10-100: 1ATERIAL &CIENCESANOMANUFACTURING TOXICITY
Exposure
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First US-China workshopPriority Areas on nano EHS
. &anomaterial Liberation in air environment
. ,reen nanomanufacturing focusing on the scientificssues arising in the systematic design of
nvironmentally benign nanoproducts and;anoprocesses
. -eries of joint US China workshops on sustainable;evelopment of nanotechnologies
. n international Institute for Sustainable-anotechnology Development as a world wide hub of
.xchange and cooperation
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Modifications, Processing and Performance
Exposure Assessment
Human and Environmental Toxicity
:A PROPOSED CONCEPTUAL MODEL. . . ., ,Grant proposal to NSF P I R E Chen J PI
&RESEARCHEDUCATIONComponents
INTERNATIONALInterdisciplinary
3 Test Systems
that reflectcommercializati
on stages
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NM SYNTHESIS& PERFORMANCE
StructuralMechanicalElectricalPhotodegradation Antimicrobial
activity
Physicochemicalcharacterization
HUMAN EXPOSURES
Inhalation Number
concentration
Size
Distribution Surface areaMorphology Chemical
analysis
Dermal
TOXICITY EVALUATIONTiered approach
.1 SCREENING Oxidative Stress in
human serum
:Cellular toxicityMultiple endpoints in
human lung cells( ¯ophages
)endothelial andbacteria
. ( )2 Animal Toxicity limited
.3 Biomarkers in humans
. :4 Environmental impact Effectson wastewater treatment
bacteria
Thrust 1 Thrust 2 Thrust 3
METRICS