Beginning of the chapter Oxidative stress, substances and genetics (Toxo Sensor) 30.
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Beginning of the chapter Oxidative stress, substances and genetics (Toxo Sensor) 30
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Transcript of Beginning of the chapter Oxidative stress, substances and genetics (Toxo Sensor) 30.
Beginning of the chapterOxidative stress, substances and genetics
(Toxo Sensor)
30
OXIDATIVE STRESS
Free radicals damage the cells
OXIDATIVE OXIDATIVE STRESSSTRESS
Free radicalsFree radicals
AGEINGAGEINGCANCERCANCER
OXIDATIVE STRESS
Free radicals damage the cells
CYTOPLASM OF A CELL
Superoxide
Hydrogen peroxide
SOD2SOD2
SOD1SOD1
SOD3SOD3
5% oxygen5% oxygen
MITOCHONDRIA
OXIDATIVE STRESS
Free radicals
OXIDATIVE STRESS
GPX1 – a selenoprotein
GPX1GPX1
GPX1GPX1Selenium
Free Free radicalsradicals
OXIDATIVE STRESS
GPX1 – a selenoprotein
GPX1GPX1
GPX1GPX1
SeleniumFree Free radicalsradicals
OXIDATIVE STRESS
GPX1 – a selenoprotein
GPX1GPX1
GPX1GPX1
Selenium
OXIDATIVE STRESS
GPX1 – a selenoprotein
GPX1GPX1
GPX1GPX1
NeutralisedNeutralised
Selenium
OXIDATIVE STRESS
Selenium deficiency and GPX1
Selenium deficiency30% Activity
More selenium70% Activity
OXIDATIVE STRESS
Polymorphism in the GPX1 gene
GPX1GPX1
GPX1GPX1
Free Free radicalsradicals
OXIDATIVE STRESS
GPX1GPX1
GPX1GPX1
Free Free radicalsradicals
Selenium
Polymorphism in the GPX1 gene
OXIDATIVE STRESS
GPX1GPX1
GPX1GPX1
Poorer binding Poorer binding (for example, 50% worse)(for example, 50% worse)Selenium
Polymorphism in the GPX1 gene
OXIDATIVE STRESS
Normal levels of Selenium
35% Activity
More selenium60% Activity
Polymorphism in the GPX1 gene
OXIDATIVE STRESS
Free radicals
OXIDATIVE STRESS
Coenzyme Q10
Q10Q10
NQO1 NQO1
Q10Q10
UBIUBIUBIUBI Free Free radicalsradicals
Q10 – No effectQ10 – No effect
UbiquinolUbiquinolantioxidant effectantioxidant effect UBIUBIUBIUBI
OXIDATIVE STRESS
Free radicals
OXIDATIVE STRESS
Coenzyme Q10
Q10Q10
NQO1 NQO1
Free Free radicalsradicals
Q10 – No effectQ10 – No effect
Q10Q10
UBIUBIUBIUBI
UBIUBIUBIUBI
UBIUBIUBIUBI
UBIUBIUBIUBI UBIUBIUBIUBI
UBIUBIUBIUBIUBIUBIUBIUBI
OXIDATIVE STRESS
Coenzyme Q10
Q10Q10
NQO1 NQO1
Free Free radicalsradicals
Q10 – No effectQ10 – No effect
Q10Q10
CC
EE
ALAALA
CCEE
EE ALAALACC
ALAALA
EE
OXIDATIVE STRESS
Oxidative stress, what to do now?
RECOMMENDATIONSRECOMMENDATIONS
1)1)Antioxidant-rich dietAntioxidant-rich diet2)2)Additional intake of free-radical scavengersAdditional intake of free-radical scavengers
1)1) Vitamin CVitamin C2)2) Vitamin EVitamin E3)3) ß-caroteneß-carotene4)4) Alpha lipoic acid Alpha lipoic acid 5)5) Coenzyme Q10? Coenzyme Q10? Ubiquinol?Ubiquinol?6)6) Selenium – how much? GPX1-geneSelenium – how much? GPX1-gene
3)3)2 2 Cups of coffee/day for 7 delay of the breast cancer Cups of coffee/day for 7 delay of the breast cancer occurrence?occurrence?
OXIDATIVE STRESS
Oxidative stress, what to do now?
SUBSTANCES
The effect of various substances on our body
SUBSTANCES
The effect of various substances on our body
End of the chapterOxidative stress, substances and genetics
(Toxo Sensor)
30
