PRIMOS

product guide 2007

3D skin measuring solutions

- PRIMOS compact

- PRIMOS portable

- PRIMOS high resolution

- PRIMOS body

- software

- accessories

- services / training

Beauty ...

... is measurable

PRIMOS International

GFM products are available worldwide and used in 22 countries. For questions regarding the usage of PRIMOS for future tasks in your company or institute or pricing, feel free to contact us or our authorized GFM international distributor at any time.

GFM 3D in vivo optical measurement of skin

www.gfmesstechnik.com

info@gfmesstechnik.com

2424Measuring capabilitiesMeasuring capabilities

2323Reference customerReference customer

2020Scientific Publication Scientific Publication

1919Service and supportService and support

1818CanfieldCanfield’’s s StereotacticStereotactic face deviceface device

1616Software PRIMOS body Software PRIMOS body -- SoftSoft

1414Software PRIMOS compact Software PRIMOS compact -- SoftSoft

1313Technology und SoftwareTechnology und Software

1111PRIMOS bodyPRIMOS body

99PRIMOS compact 90 x 70, 120 x 160PRIMOS compact 90 x 70, 120 x 160

77PRIMOS compact high resolutionPRIMOS compact high resolution

33PRIMOS compact portablePRIMOS compact portable

22General informationGeneral information

pageContentsContents

PRIMOS 3D optical measurement

… the first choice in 3D skin imaging solutions

Dear professional

As a measuring method of the contact-less working optical 3D measuring device PRIMOS compact uses a digital stripe projection based on micro mirrors which allows for fast and highly precise measuring data acquisition. An assortment of different measuring fields, realised by means of different precise recording optics, ensures a wide spectrum of measuring possib-ilities with ranges up to micrometers. A closed calibration concept, a calibration method aligned to the measuring system and the use of appropriate adjusting pieces, guarantees comp-liance with the specified accuracies.

GFMesstechnik GmbH business areas include the development, manufacturing and marketing of optical measuring and inspection systems as well as appropriate measuring and evaluation software. GFMesstechnik measurement technology stands for computer-assisted surface measuring systems and software based on non-destructive optical measuring and testing methods. With PRIMOS skin devices it is possible to record different sizes of skin surfaces fast and precisely.

Treated parts of the skin can be evaluated for all necessary parameters, e.g. roughness, volumes and dimensions of wrinkles or scars, etc.. The software allows retrieval of highly precise skin areas measured before and after a medical or cosmetic treatment. Application fields are clinical applications, dermatology, aesthetic medicine and biometry.

Measurement of crow's feet with PRIMOS compact

PRIMOS 3D optical measurement… quantitative skin measurement within

milliseconds

The PRIMOS portable device is the system of choice for everyone who requires flexibility, yet would still enjoy measuring many different areas of the body. The compact design of the system and the simple operation grant such flexibility without a complex tripod. The recording speed coupled with robust measuring modes grants reliable, stable measurements irrespective of movements from user or patient.

The only worldwide, hand-guided 3D in vivo skin measuring system based on digital strip projection combined a high precise 3D skin measurements with maximum flexibility. The speed of under 70ms for the measuring data admission provide perfect results of measurement.

technical data

Measuring field : [mm²] 40 x 30 Lateral resolution : [µm] 63Height resolution : [µm] ≥ 4Accuracy: [µm] ≥ 6Data acquisition time: [ms] < 70

GFM PRIMOS compact portable is a flexible hand-held device

PRIMOS compact portable

... simple, flexible 3D measuring

Key Features

• Flexible one in vivo measurements

• Hand-guided 3D sensor

• Integrated source of light

• Easy operation with mobile PC

• Current software-Version 5,2 with overlay and Matchingfunction

• 3D photographs with color texture

Application: Measurement and evaluation from eye wrinkles to the analysis of anti- Aging products

Data acquisition

With PRIMOS compact it is possible to seize the color texture to to combine and represent with the three-dimensional data record. The 3D colorrepresentations is particularly suitable for your marketing of projects, presentations and studies.

Evaluation on the basis profile lines

2D profile selection

3D data before & after comparison the Matching

Difference measurement at the profil selection

PRIMOS compact portable

... Analyse of the skin surface with a measuring field

of 40 x 30mm²

In the filtered picture as many lines as desired, can be inserted and be represented in a profile in the sectional view. On the sectional view there can be numerous geometrical measurements such as depth, distance, radius etc. The Matching function makes the direct comparison possible for two or more data records.

3D data combined with colour texture

Application: Evaluation of wrinkles volumes

Automatic detektion of a fire scar

Colour coded 3D elevator picture after the filtering

3D representation with colour texture

Index of the results of measurement

PRIMOS compact portable

... Analyse of the skin surface with a measuring field

of 40 x 30mm²

Volume measurement of eye folds

The volume determination of eye folds is for many users a principal purpose, in order to better note significant changes and retain statistically precise representations. For these ranges, those which will be included into the computation are marked. As result of the measurements you will, in the end, receive the volume of the marked folds.

Automatic computation of scars and skin knots

For individual, and multiple evaluation of scarsor skin knots in the measuring field, you can use an automatic evaluation algorithm. This function recognizes all maxima or depth and calculated volume, extent and max. height (depth) independently. The measurement results are then displayed in tabular form.

GFM PRIMOS Sensor combined with Canfield’s StereotacticTripod for simplified positioning

PRIMOS compact portable

... various combination options

Recommended applications for PRIMOS compact portable

üWrinkles

üNaevi, Neurofibroma, Acne

ü Wounds

üScars

üMelanoma (Topography)

The 3D sensor, and its specially constructed tripod, can be installed with minimal handling. With the help of this stand, special photographs can be accomplished and the face range more easily and more exactly acquired, in the shortest time possible. The positioning of the sensor is easily maneuvered so that the test person can relax into the tripod which can rotate around 150 °.

Key Features

• Most recommended device in skin research

• Measurements of larger structure and roughness with only 1 device!

• Latest software PRIMOS 5.3 incl. matching function for treatment control

technical data

Measuring field : [mm²] 24 x 15Measuring points : 1000 x 800Lateral resolution : [µm] 24Height resolution : [µm] ≥ 2Accuracy: [µm] ≥ 3Data acquisition time: [ms] <70

GFM PRIMOS Sensor combined with Canfield’s Stereotactic face device

PRIMOS compact high resolution

... 3D measurements for highest requirements

PRIMOS compact high resolution combines the advantages of a large measuring field with a high resolution without compromises! It is a recommended instrument for the user to obtain: skin textures, as well as roughness and smoothness, larger structures, such as crows feet or wounds, to measure and/or scars precisely and fast.

The PRIMOS compact high resolution measuring system was developed, in order to

meet the highest requirements for research and science. The skin, as a mirror of

the soul and health, takes a key role in the evaluation of pharmaceutical and

cosmetic products. The increasing number of these products requires objective

valuation criteria and measuring instruments.

Recommended applications for PRIMOS high resolution

üRoughness

üFine lines

üWrinkles

üWounds, Scars

üReplica

Source 3D image of an area around the eye

Color coded 3D profile after filtering with cut

line

Cross section with depth measurement

Source 3D image of the skin micro profile

Automatic evaluation of star or surface roughness parameters such as Ra, Rz,… Sa, Sz,…

PRIMOS compact high resolution

... high end research skin measurement

Applications: Analysis of crow’s feet and fine lines, 3D image captured with PRIMOS compact high resolution

technical data

Measuring field : [mm²] 90 x 70 [mm²] 160 x 120

Measuring points : 640 x 480 640 x 480Lateral resolution : [µm] 140 [µm] 250 Height resolution : [µm] ≥ 9 [µm] ≥ 12 Accuracy: [µm] ≥ 14 [µm] ≥ 25Data acquisition time: [ms] <70 [ms] <70

Key Features

• Large field 3D measurements

• Use with mobile PC possible

• Latest software PRIMOS 5.05

• Color Firewire camera

PRIMOS compact

... measuring field: 90 x 70 mm² and 160 x 120 mm²

The PRIMOS compact large field systems are ideal for the investigation and documentation of skin macrostructures such as nasiolabial folds, large scars and wounds, cellulite and parts of the face and body such as hands, feet or breast.

In combination with different types of tripods you will be able to perform measurements over the entire body. The PRIMOS system is equippedwith a fast color camera which provides fast imaging and perfect color textures.

Recommended applications for PRIMOS 90x70 mm² and 160x120 mm²

üParts of the Face

üLarge wounds and scars

üNasiolabial fold

üCellulite

üBreast

üHand, feet

Geometric measurements on the cross section

3D point cloud with cut line from

forehead to the lips

PRIMOS compact

... measuring field: 90 x 70 mm² and 160 x 120 mm²

Measurement the thigh for the objective evaluation of Cellulite

Applications

Evaluation of the skin surface at the 3D elevation picture

Technical data

Measuring field : [mm²] 300 x 300Measuring points : 1200 x 1000Lateral resolution : [µm] 500Height resolution : [µm] ≥ 30Accuracy: [µm] ≥ 30 Data acquisition time: [ms] < 140

Key Features

• Large field 3D measurements

• 6.1 M-Pixel color texture

• Fast and easy face measurement

• Easy portable

• Latest software PRIMOS body 6.2 incl. Matching function for teatment control

• *.stl data export

The Sensor includes the stripe projector and three fast cameras for the 3D image

and the color textures

Simple handling

PRIMOS body

Fast 3D measurement supplemented by acquisition of colour texture in a brilliant 6.1 Mega pixel quality. The large field measuring system

PRIMOS body is the recommended device for precise face and body measurements. You can capture a complete face with only

1 measurement in 140 ms! The use of newest technologies supply objective measuring results for treatment control and many other

applications. The exported polygon data allows direct import into production line for perfect fitting items like masks or artificial replacements. The software supplies all essential functions for the evaluation and presentation of 2D and 3D measuring data.

Recommended applications for PRIMOS body

üComplete Face

üParts of the body (belly, arm, leg…)

üCellulite

üBreast

3D picture with high resolution color texture

3D point cloud of the face

Further possibilities for the use of a PRIMOS body measurement system. Full digitized doll in two views and a human leg with feet.

PRIMOS body

Geometrical measurements of the profile section

Applications

Reproducible retakes succeed perfectly with the integrated OVERLAY function. A camera picture of the last shoot is faded in transparency background of the live picture and you can align the sensor millimeter-exactly. A project cross-line screen guarantees the correct focus to the item being tested.

Two functions integrated in the standard software help you with regaining and comparison of the measured skin areas.

The fine tuning takes over the matchingfunction of the software. In addition the reference data record and a measuring data set are loaded. The measuring data set is aligned in such a way that the measuring area agrees accurately with the reference. Now, i t is possible to compare the data records with another and to determine differences in the skin structure.

3D data before & after comparison after the Matching

Overlay and live picture Overlay and live picture after adjustment

PRIMOS compact

... technology & software

Skin measurement in video real time is unthinkable without the use of sophisticated measurement and evaluation software. Only trough fast processing and user-oriented presentation of results, measured data are transformed into relevant information.

Our measurement system and evaluation software are developed completely in Germany by GFM, ensuring a maximum efficiency in the collection and evaluation of measuring data.

From a close and continuing cooperation with users, a software solution results offers results which are optimally adapted to the requirements of daily use in the field of cosmetics industry and medicine, e.g. dermatology.

Contained in the PRIMOS software package are all necessary functions for the measuring of skin surfaces, including the determination of 2D/3D roughness parameters and of star and surface roughness.

Also included in the software are geometric measurement options like the measurement of distances, radii, angles and volumes, e.g., of skin wrinkles.

Application

• Software complete solution for the use in cosmetics research, industry and in medicine

• Measurement of skin surfaces and replica

Features

• Fast evaluation algorithms

• Employed in adapted to the skin measurement systems

• Clearly arranged 2D and 3D representation of results

• Integration of special evaluation algorithms for skin measurement, e. g. star roughness, matching of skin areas etc.

• Comprehensive interfaces for export and import data

• Database functionality for the storage and evaluation of large amounts of data or serial measurement

• Rich set of functions for 2D and 3D data evaluation

Advantages

• Efficient through adaptation to the measurement system used

• Large set of functions and options

• Customer specific extensions can be realized fast

PRIMOS compact - Soft

... complete software solution for skin measurement and

evaluation in cosmetics and medicine

Measuring systems• Primos optical measurement devices for in vivo skin

measuring or skin replica measuring

• Third part measuring devices with special data interface

Supported measuring modes• In vivo measurement of skin

• High precision fast replica measurement

Evaluation functionality• Basic filtering

(e.g. Mean, Gauss, Media, Fourier)

• Polynomial filtering from degree 1to 8

• Robust high pass filtering

• Line roughness

(e.g. Ra, Rz, Rq, Rmax, R3zmax, Rp, Rk, Riso, Rc, Sm, Wt)

• Star roughness for 3 up to 16 angle positions

(e.g. Ra, Rz, Rq, Rmax, R3zmax, Rp, Rk, Riso, Rc, Sm, Wt)

• Surface roughness

(e.g. Sa, Sz, Sq, Smax, S3zmax, Sp, Sk, Siso, Sc)

• Matching of skin areas

(3D matching, compensation of stretching, visualization of deviations)

• Measurement of skin series

• Database functionality

Data representation • Color coded high picture with editable scale

• Sectional view with interactive measuring and labeling

• 3D Visualisation of skin topography

(interactive 3D function for rotating, orientation, zoom, scaling, etc.)

• Graphical and numerical prints of measuring results

Data interface• Import filter

(e.g. ASCII, stl)

• Export filter

(e.g. ASCII, BMP, JPG, TXT, WMF, SDF, FD3)

Operating system • Windows 2000 / XP

Skin roughness

Wrinkles, 3D color coded visualization

Wound and scar measuring

Matching of skin areas

PRIMOS compact - Soft

Technical data

Applications

• Complete software solution for measurement and evaluation

• 3D measurements of faces and parts of the body specialized for the use in the plastic surgery and medicine

Characteristics

• Quick evaluation algorithms

• Results are presented in 2D and 3D shape

• Matching function to define differences after a cosmetic or surgery treatment

• Extensive interfaces to the import and export of data like ASCII *.stl –data for direct import into production machinery

• Data base functionality for the storage and evaluation of larger data sets or of series measurements

• Various possibilities for the evaluation of the data and determinations of geometry such as lengths, radii, angles and volumes

3D pictures with color texture in the evaluation area before matching

After the matching the right image shows the differences

Cross section picture along the cut line of both images shown in the

picture above.

PRIMOS compact body - Soft... evaluation software for professional face and body

measurements

Determination of geometrical dimensions of the chest along the cut line

Measuring system

PRIMOS body face and body measuring system for the fast in vivo measurement

Result representation2D and 3D representationConvert in CAD-readable data (polygon)point clouds3D images

Data Interfaces

Import filter( ASCII, BMP, SDF, STL)Export filter( ASCII, BMP, SDF, STL)

System requirementsMicrosoft Windows 9x or NT 4.0Pentium III >600 MHz, 128MB RAM

3D-shape of a chest range with color texture at the profile section with a cut line

Difference picture with marked areas of interest around & near the lips

Automatic evaluation of the difference volume, surface and average height

PRIMOS compact body - Soft... evaluation software for professional face and body

measurements

Application

• Measurement of wrinkles, scars, wounds and all topographical characteristics within the face range in combination with a PRIMOS compact sensor from 13x18mm² - 120 x 160mm²

Characteristics

• Easily positioning of the sensor in X, Y and Z direction

• Angle exact turn of the chin and front mounting plate to the sensor

• Firm footing by suction feet and balanced emphasis

Advantages

• Accuracy and reproducible positioning of the sensor

• Pixel-exact area regaining for process controls of medical and cosmetic treatments

• Simple calibration of the sensor by an easily mountable plate for normal calibration

Precision stand for face positioning with the 3D in vivo skin measurement

Canfield’s Stereotactic Face Device

GFMesstechnik

... service & support

User Training

The claim of GFMesstechnik is to supply the best technique in optical 3D measurement. Therefore we are always endeavored to improve and develop our products. To reach optimal results with its PRIMOS measuring instrument it will be necessary to work with the optimal system but also to know about the handling of these systems. Therefore we recommend to make use of our offer for user training. GFM support team employees will complete the installation of your measuring instrument in your office, and they will train your staff in the handling of the equipment and in the evaluation of the raised data. The recommendation is to get a one day training session after installation and another one, or two, day training session approximately 8 weeks after installation.

The user training contains:

• Hardware installation

• Ancillary conditions for the measurement

• Software handling

• Measurement options

• 3D presentation and result presentation

• Saving results

• Volumetric measurement

• Roughness evaluation and parameter

• Using of database

• Appraisal of results

• Lasers in Surgery and Medicine 36:85-91 (2205)Clinical trial of a Novel Non-Thermal LED Array for Reversal of Photoaging: Clinical, Histologic and Surface Profilometrie resultsRobert A. Weiss, David H. McDaniel, Roy G Geronemus, Margaret A. Weiss

Scientific publications

... PRIMOS measuring devices*

* This list is not exhaustive- please find more links at our webside

• Skin Research and Technology 2004 Nov;10(4):207 - 14 In vivo determination of skin surface topography using an optical 3D device.Jacobi U; Chen M; Frankowski G; Sinkgraven R; Hund M; Rzany B; Sterry W; Lademann J

• Medical Laser Application Dec. 2004Subjective Evaluation and Objective Measurement Methods in Cosmetic Dermatology Jean Luc Levy, Frederic Pons, Lise Agopian, and Regis Besson

• Dermatol. Surgery2004; 30: 152 – 157Comparsion of a 1450-nm Diode Laser and a 1320-nm Nd:YAG Laser in the Treatment of Atrophic Facial Scars: A Prospective Clinical and Histologic StudyTanzi E. L., Alster T.S.

• Dermatol. SurgeryMarch 2002; 28(3):199-2043D in-vivo optical skin imaging for topographical quantitative assessment of non-ablative laser technologyFriedman PM, Skover GR, Payonk G, Kauvar AN, Geronemus RG

• Journal of Wound Care VOL 12, NO 9, Page 362, October 2003PRIMOS: an optical system that produces three-dimensionalmeasurements of skin surfaces.Roques C, Teot L, Frasson N, Meaume S.

• Avon, Suffern/ USA

• Beiersdorf AG, Hamburg

• BioSkin GmbH, Hamburg

• Candela Corp., Wayland/ USA

• Cetco Lima/ Peru

• Cognis, Pulnoy/ France

• Colgate-Palmolive Company,

• Consumer Product Testing Co.,

• Derma Laser Inc., Montreal

• DermaConsult, Alfter

• Dermatest, Muenster

• DermaTronnier, Witten

• Dermscan, Lyon/ France

• Dr. Prakash, London/ UK

• Dr. Zelickson, Edina/ USA

• Ellead Seoul/ Korea

• fzmb e.V., Bad Langensalza

• Gilette UK

• Henkel KGaA, Duesseldorf

• Hoffman LaRoche AG, Basel/

• Hospital Neukoelln, Berlin

• Institute of Cancer Research,

• Johnson & Johnson CI-RoC

• Johnson & Johnson Phils. Inc.,

•Johnson & Johnson, Skillman

• Kanebo/ Japan

• Kose/ Japan

•Laser & Skin Surgery Center, New York/ USA

• Light Bioscience, Virginia Beach/ USA

• L'Oreal/ Cosmair Cosmetics Corp., Clark/ USA

• Lumenis, Israel/ USA

• Massachusetts General Hospital, Boston/ USA

• Neutrogena Corp., Los Angeles/ USA

• Nippon Lever/ Japan

• O Boticario, San Jose dos Pinhas/ Brazil

• Pfizer Inc., Morris Plaints/ USA

• Philips Personal Care Institute,

• PowerPaper, Israel

• Procter & Gamble Company, Egham/ UK

• Procter & Gamble Company, Piscara/ Italy

• Procter & Gamble Far East Inc., Kobe/ Japan

• proDERM GmbH, Hamburg

• Renovo Ltd., Manchester/ UK

• Rosenparkklinik, Darmstadt

• Ruhr University of Bochum

• Skin Biology Center, Hamburg

•Technical University of Munich,

•Unilever Thailand

•Unilever, Edgewater/ USA

•Unilever UK

•Unilever Shanhai / China

•Universities: Ulm, Luebeck

•University Hospital Charité, Berlin

•University of Michigan, Ann Habor/ USA

• University of Seoul/ Korea

Reference Customer list

* This list is not exhaustive

Reference Customer - Statements

It is the fourth year of our co-operation. In the past 3 years GFM helped us - owing to good services to master our challenges gradually. PRIMOS 3D-Messgeräte - with the ingenious Design and the exact results of measurement - make us possible to win more information about product effects on the skin. Measuring e.g. of folds, fine lines, pores and skin roughness supports our

The Derma Consult GmbH, Institut specialized in testing of cosmetic, cosmetic raw materials, cleaning products and Dermatika, uses the PRIMOS Compact of systems in the context of effectiveness investigations from Cosmetics to the

measurement of the skin roughness and wrinkles depth both in vivo, and for the measurement of skin castings. This flexibility in combination with the high measuring accuracy and minimum gate times convinced us.

After one year experience with the PRIMOS system, we estimate the possibility in vivo measurement and evaluation of eye folds in our application fields anti- aging and sun protection. The system is very user friendly and

is characterised by a good performance during the measurements. At most we estimate the effective technical support and the comprehensive support. Inquiries were always answered within shortest time satisfyingly.

Recommended by: Ms. Boris Nissen, Derma Consult GmbH:

Recommended by: Ms. Dr. Olivier DOUCET, Director of Skin Research and Skin Pharmacology Team, LANCASTER COTY:

Recommended by: Mrs. Cissy Li, Unilever Research China:

marketing in singular way and leaves our dreams becomes true. We hope for more technical communication between our customers, in order to realize further improvements.

YESYESCellulite

YESYESYESBreast

YESYES

Skin Roughnessand fine lines

YESYESWrinkle

YESYESYESWound

YESYESReplica

YESFace

YESYESNasolabialFold

YESYESYESLesion / Mole

YESYESYESScar

PRMOS body

160x120 mm²90x70 mm²16x26 mm²40x30 mm²13x18 mm²

PRIMOS 3D measuring

... recommended system measuring capabilities