Bcl-2 and its Role in Cancer
description
Transcript of Bcl-2 and its Role in Cancer
![Page 1: Bcl-2 and its Role in Cancer](https://reader036.fdocuments.us/reader036/viewer/2022062520/568160fe550346895dd03db0/html5/thumbnails/1.jpg)
Bcl-2 and its Role in Cancer
![Page 2: Bcl-2 and its Role in Cancer](https://reader036.fdocuments.us/reader036/viewer/2022062520/568160fe550346895dd03db0/html5/thumbnails/2.jpg)
Mitochondria in the Cell
http://micro.magnet.fsu.edu/cells/mitochondria/images/mitochondriafigure1.jpg
![Page 3: Bcl-2 and its Role in Cancer](https://reader036.fdocuments.us/reader036/viewer/2022062520/568160fe550346895dd03db0/html5/thumbnails/3.jpg)
Cytochrome C’s Dual FunctionalityProtein that carries electrons in electron transport chain between mitochondrial membranes
BUT released into cytosol, triggers apoptosis
http://upload.wikimedia.org/wikipedia/commons/thumb/b/ba/Cytochrome_C.png/250px-Cytochrome_C.png
![Page 4: Bcl-2 and its Role in Cancer](https://reader036.fdocuments.us/reader036/viewer/2022062520/568160fe550346895dd03db0/html5/thumbnails/4.jpg)
Bcl-2 family – apoptosis regulators
http://www.cancer.gov/cancertopics/understandingcancer/targetedtherapies/lymphoma_htmlcourse/page3
![Page 5: Bcl-2 and its Role in Cancer](https://reader036.fdocuments.us/reader036/viewer/2022062520/568160fe550346895dd03db0/html5/thumbnails/5.jpg)
Stress signal (DNA damage, heat shock)
Pro-apoptotic members activated
Cytochrome c release via MOMP
Cytochrome c complexes with ATP and Apaf-1 (enzyme)
Caspase-9 activated, then forms apoptosome with previous complex
Caspase cascade to apoptosis
http://www.reading.ac.uk/nitricoxide/intro/apoptosis/mito2.jpgApoptosis Pathway
![Page 6: Bcl-2 and its Role in Cancer](https://reader036.fdocuments.us/reader036/viewer/2022062520/568160fe550346895dd03db0/html5/thumbnails/6.jpg)
http://openi.nlm.nih.gov/detailedresult.php?img=2132464_JCB.amling5g&req=4
• Viable, but smaller• Half die by 6 weeks• Smaller kidneys• Skeletal
development• Immune failure
Bcl-2 Knockout Mice
![Page 7: Bcl-2 and its Role in Cancer](https://reader036.fdocuments.us/reader036/viewer/2022062520/568160fe550346895dd03db0/html5/thumbnails/7.jpg)
https://encrypted-tbn3.gstatic.com/images?q=tbn:ANd9GcTkoz4iPsXeDUTi1dbV1wzIQsD8sDB7HqkRJaxih9U4UWe9Cusd-A
Non-Hodgkin
Lymphoma
![Page 8: Bcl-2 and its Role in Cancer](https://reader036.fdocuments.us/reader036/viewer/2022062520/568160fe550346895dd03db0/html5/thumbnails/8.jpg)
http://www.sciencedirect.com/science/article/pii/S0167488903001885
Bcl-2 Translocations Found in Cancer
![Page 9: Bcl-2 and its Role in Cancer](https://reader036.fdocuments.us/reader036/viewer/2022062520/568160fe550346895dd03db0/html5/thumbnails/9.jpg)
http://www.cancer.gov/cancertopics/understandingcancer/targetedtherapies/lymphoma_htmlcourse/page3
Overexpression of Bcl-2 on the Outer Membrane of Mitochondria
![Page 10: Bcl-2 and its Role in Cancer](https://reader036.fdocuments.us/reader036/viewer/2022062520/568160fe550346895dd03db0/html5/thumbnails/10.jpg)
Inhibiting Bcl-2
http://www.cancer.gov/images/targetedtherapies/lymphoma/m4s3c_1.jpg
![Page 11: Bcl-2 and its Role in Cancer](https://reader036.fdocuments.us/reader036/viewer/2022062520/568160fe550346895dd03db0/html5/thumbnails/11.jpg)
http://www.cancer.gov/PublishedContent/Images/images/targetedtherapies/lymphoma/m4s3c_3.jpg
Potential Therapeutic Undergoing Clinical Trials
![Page 12: Bcl-2 and its Role in Cancer](https://reader036.fdocuments.us/reader036/viewer/2022062520/568160fe550346895dd03db0/html5/thumbnails/12.jpg)
Sources
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132464/
• http://www.scq.ubc.ca/apoptosis/• http://www.ncbi.nlm.nih.gov/pmc/articles/
PMC3220196/pdf/iep_79.pdf• http://www.cancer.gov/cancertopics/
understandingcancer/targetedtherapies/lymphoma_htmlcourse
• http://www.sciencedirect.com/science/article/pii/S0167488903001885