BBS3027 2000: Infectious Diseases Dr Garwin Sing [email protected]
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Transcript of BBS3027 2000: Infectious Diseases Dr Garwin Sing [email protected]
BBS3027 2000: Infectious Diseases
Dr Garwin Sing
http://trishul.sci.gu.edu.au/courses/bbs3027/
Gut Mucosa
Gut Mucosa
Mucosal Epithelium
Epithelial Barriers to Microbial Infection: Physical
• Epithelial cells joined by tight junctions
• Exfoliation of surface cells
• Mucous flow by ciliated epithelia (respiratory tract)
Epithelial Barriers to Microbial Infection: Chemical
• Enzymes: Lysozyme (tears, saliva, sweat) Pepsin (stomach)
• pH: Fatty Acids/amino acids (skin)Gastric acids (stomach)
• Antimicrobial: Transferrin (mucus)
Epithelial Barriers to Microbial Infection:
Competition
• Gut Flora
Protection from Infectious Agents
• Innate Immunity Fever, interferon, neutrophils,
macrophages, NK cells
• Adaptive Immunity B cells, T cells
Congenital Infections
Viruses
Bacteria
Fungi
Parasites
Anatomy
Physiology
Immunity
Commensals
Sources of Infection: Exogenous
• InhalationCommon cold, flu, Legionnaire’s Disease, Coccidioidomycosis
• Ingestion Typhoid fever, tapeworm,cryptosporidium, Hepatitis A
• STD Gonorrhea, HIV• Wound Tetanus, Rabies• Insect Bite Malaria, Yellow Fever,
Dengue
Sources of Infection: Endogenous
• Gut e.g E coli
• Skin e.g. staphylococcus
• Tonsils
• Throat e.g streptococcus
• Blood e.g. EBV
• Lungs e.g Candida, CMV, streptococcus