Basic Cellular Concepts John P. McDonough, CRNA, Ed.D., ARNP.
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Transcript of Basic Cellular Concepts John P. McDonough, CRNA, Ed.D., ARNP.
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Basic Cellular Concepts Basic Cellular Concepts
John P. McDonough,John P. McDonough, CRNA, Ed.D., ARNPCRNA, Ed.D., ARNP
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Cellular FunctionsCellular Functions
Cells become specialized through Cells become specialized through differentiationdifferentiation. . The 7 chief functions are: The 7 chief functions are:– movementmovement– conductivityconductivity– metabolic absorptionmetabolic absorption– secretionsecretion– excretionexcretion– respirationrespiration– reproductionreproduction
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Structure & Function of Typical Structure & Function of Typical “eukaryotic” Cell“eukaryotic” Cell
The 3 components:The 3 components: Plasma membrane (plasmalemma)Plasma membrane (plasmalemma) CytoplasmCytoplasm OrganellesOrganelles
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OrganellesOrganelles
NucleousNucleous– surrounded by cytoplasm (not a cytoplasmic surrounded by cytoplasm (not a cytoplasmic
organelle)organelle)– largest membrane bound organellelargest membrane bound organelle– 2 membrane “nuclear envelope”2 membrane “nuclear envelope”– nucleolus (houses DNA, histones, etc)nucleolus (houses DNA, histones, etc)– controls cell division and genetic informationcontrols cell division and genetic information
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Organelles (con’t)Organelles (con’t)
RibosomesRibosomes Endoplasmic reticulum Endoplasmic reticulum Golgi complexGolgi complex LysosomesLysosomes PerioxomesPerioxomes Mitochondria Mitochondria Cytoskeleton Cytoskeleton Microtubules & Actin filamentsMicrotubules & Actin filaments
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Cellular ReceptorsCellular Receptors
Protein molecules capable of:Protein molecules capable of:– recognizing ligandsrecognizing ligands– binding with ligandsbinding with ligands
Classified on basis of location and functionClassified on basis of location and function Receptors for drugs are found on the Receptors for drugs are found on the
membrane, cytoplasm & nucleusmembrane, cytoplasm & nucleus Membrane receptors are known for:Membrane receptors are known for:
– anesthetics, opiates, endorphins, enkephalins, etc.anesthetics, opiates, endorphins, enkephalins, etc.
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Cell-To-Cell CommunicationCell-To-Cell Communication
EndocrineEndocrine ParacrineParacrine AutocrineAutocrine SynapticSynaptic
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Cellular Intake & OutputCellular Intake & Output
Cells continually have “in & out” trafficCells continually have “in & out” traffic Passive transport (no Passive transport (no lifelife required) required)
– diffusiondiffusion– hydrostatic pressurehydrostatic pressure– osmosis osmosis
Active transportActive transport– requires energyrequires energy– requires receptors requires receptors
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Active Transport of NaActive Transport of Na++ & K & K++
Found in virtually all mammalian cellsFound in virtually all mammalian cells Na Na ++ moves in, K moves in, K++ moves out moves out Uses energy of ATP (60-70% total used)Uses energy of ATP (60-70% total used) Transporter is an enzymeTransporter is an enzyme
– ATPaseATPase Skeletal & cardiac muscle pumps CaSkeletal & cardiac muscle pumps Ca++ ++ alsoalso
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Types of TissuesTypes of Tissues
Epithelial (simple & stratified) Epithelial (simple & stratified) – covers most internal & external surfacescovers most internal & external surfaces– attached to a basement membraneattached to a basement membrane– surfaces differ according to locationsurfaces differ according to location
» smooth smooth
» microvillimicrovilli
» ciliacilia
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Types of Tissues (Con’t)Types of Tissues (Con’t)
ConnectiveConnective– varies in structure & functionvaries in structure & function– framework on which epithelial cells clusterframework on which epithelial cells cluster– abundant extracellular matrixabundant extracellular matrix
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Types of Tissues (Con’t)Types of Tissues (Con’t)
MuscleMuscle– made up of myocytesmade up of myocytes– highly contractilehighly contractile– 3 major types3 major types
» skeletal (striated) skeletal (striated)
» cardiaccardiac
» smoothsmooth
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Types of Tissues (Con’t)Types of Tissues (Con’t)
NeuralNeural– receive & transmit electrical impulsesreceive & transmit electrical impulses– transmitted across synapses transmitted across synapses
» nerve to nervenerve to nerve» nerve to musclenerve to muscle» transmission achieved with neurotransmitters transmission achieved with neurotransmitters » total number fixed at birthtotal number fixed at birth
– all neurons have:all neurons have:» 1 cell body, 1 axon, 1 or more dendrites 1 cell body, 1 axon, 1 or more dendrites
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Cellular AdaptationCellular Adaptation
AtrophyAtrophy– decrease in cell sizedecrease in cell size– if enough cells if enough cells in size, so will organ in size, so will organ– disuse atrophydisuse atrophy– nutrition deprivationnutrition deprivation– atrophy due to atrophy due to physiological stimulation physiological stimulation
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Cellular AdaptationCellular Adaptation
HypertrophyHypertrophy– increase in cell sizeincrease in cell size– heart & kidneys particularly responsiveheart & kidneys particularly responsive– associated with associated with in cell protein, not in cell protein, not in water in water– hypertrophy may be normalhypertrophy may be normal
» muscle in exercise muscle in exercise
» uterus and mammary glands in pregnancyuterus and mammary glands in pregnancy
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Cellular AdaptationCellular Adaptation
HyperplasiaHyperplasia cell numbers from cell numbers from cell division cell division – normal (physiologic)normal (physiologic)
» compensatorycompensatory» hormonal hormonal
– pathologicalpathological» abnormal proliferation of normal cellsabnormal proliferation of normal cells» endometrium most common siteendometrium most common site» failure of growth controlfailure of growth control malignant transformation malignant transformation
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Cellular AdaptationCellular Adaptation
DysplasiaDysplasia– ““atypical hyperplasia”atypical hyperplasia”– abnormal changes in size, shape & organizationabnormal changes in size, shape & organization– seen in epithelial cells of the cervix & resp tractseen in epithelial cells of the cervix & resp tract– graded low graded low high high– when inciting stimuli removed when inciting stimuli removed reversible reversible
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Cellular AdaptationCellular Adaptation
MetaplasiaMetaplasia– reversible replacement reversible replacement
» one mature cell type by anotherone mature cell type by another
– reversed if inducing stimuli removedreversed if inducing stimuli removed– prolonged exposure prolonged exposure malignant malignant
transformationtransformation
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Common Areas in Cellular InjuryCommon Areas in Cellular Injury
ATP depletionATP depletion Oxygen derived free radicalsOxygen derived free radicals cytosolic Cacytosolic Ca++++ Defects in membrane permeability Defects in membrane permeability
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Cellular InjuryCellular Injury
Adaptation Adaptation ReversibleReversible IrreversibleIrreversible NecrosisNecrosis ApoptosisApoptosis
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Cellular InjuryCellular Injury
HypoxicHypoxic– ischemia Vs hypoxiaischemia Vs hypoxia
Chemical injuryChemical injury– lead, CO, ethanol, recreational drugslead, CO, ethanol, recreational drugs
Infectious Infectious Immunologic & inflammatoryImmunologic & inflammatory Injurious genetic factors Injurious genetic factors
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Cellular InjuryCellular Injury
Nutritional imbalancesNutritional imbalances Injurious physical agentsInjurious physical agents
– thermal injury thermal injury – Ionizing radiationIonizing radiation– IlluminationIllumination– Mechanical stressMechanical stress– NoiseNoise
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AgingAging
AtrophyAtrophy Decreased functionDecreased function Loss of cells (? Apoptosis)Loss of cells (? Apoptosis) Compensatory changesCompensatory changes
– hypertrophy, hyperplasia, hypertrophy, hyperplasia, metaplasia metaplasia dysplasia dysplasia neoplasia neoplasia