Basic and Clinical Pharmacology 13 · Web viewFor the Pharmacology of the Central Nervous System,...

OUTCOMES-BASED EDUCATION PHARMACOLOGY and TOXICOLOGY

SILLIMAN UNIVERSITYINSTITUTE OF CLINICAL LABORATORY SCIENCES

VISION (INSTITUTIONAL) INSTITUTIONAL INTENDED LEARNING OUTCOMES (IILOs)

To be a leading Christian institution committed to total humandevelopment for the well-being of society and environment.

ICLS has identified the learning outcomes which represent the qualities that all ICLS medical technology students should possess when they graduate. These outcomes are anchored on the Visible Outcomes and Operational Indicators of a Good Silliman Graduate.

1. Creative critical thinker – Demonstrate the ability to ask pertinent questions, to look at the world in a correct and creative way and to learn with others

2. Transformative Christian witness – Live out the Via, Veritas, Vita to make social impact (environmental stewardship), serve others, lead an exemplary life, know and act on what is right and wrong, good or bad, see the Divine in all that is in the world and become an image of God’s justice and love to others.

3. Effective communicator– Demonstrate the ability to actively participate in social disclosure

4. Independent, reflective, life-long learner – Manifest ability to ask pertinent questions, to look at the world in a correct and creative way and to learn with others

MISSION (INSTITUTIONAL)

1. Infuse into the academic learning the Christian faith anchored on the gospel of Jesus Christ; provide an environment where Christian fellowship and relationship can be nurtured and promoted.

2. Provide opportunities for growth and excellence in every dimension of the Universitylife in order to strengthen character, competence and faith.

3. Instill in all members of the University community an enlightened socialconsciousness and a deep sense of justice and compassion.

4. Promote unity among peoples and contribute to national development.

PROGRAM MISSION PROGRAM VISIONThe Institute of Clinical Laboratory Sciences shall:

1. Provide holistic education in a Christian context.2. Pursue with determination the standards of faith, instruction, research

and extension.3. Produce graduates with abilities to work in collaboration with other

members of the health team in any setting.4. Produce competent graduates who are locally relevant and globally

comparable5. Produce competent Medical Technology graduates who possess Christian

values with commitment to serve the community and uphold the integrity of our environment.

We envision Institute of Clinical Laboratory Sciences to be the leading institution in the Philippines in producing Christian men and women who are globally-competent in exercising the Medical Technology profession with skill, knowledge, and with a personal commitment

to Godly living.

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PROGRAM EDUCATIONAL OBJECTIVES (PEO) PROGRAM OUTCOMES (PO)To produce graduates who are:

1. competent technologists; Graduates can use theoretical knowledge of clinical laboratory medicine in practical applications.

2. independent learners;Graduates are capable of self-management and professional growth.

3. effective communicators; Graduates are able to understand, appraise and communicate data in various forms.

4. critical problem solvers; Graduates can use critical thinking to identify problems and generate solutions.

5. efficient system managers; Graduates can use the principles of interdependence as a means of realizing universal goals.

6. and Christian witnesses. Graduates are guided by the Via, Veritas, Vita in their professional interactions.

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ALIGNMENT OF PROGRAM MISSION WITH PROGRAM EDUCATIONAL OBJECTIVESMISSION DESCRIPTION PEO 1 PEO 2 PEO 3 PEO 4 PEO 5 PEO 6

M1 Provide holistic education in a Christian context M2 Pursue with determination the standards of faith,

instruction, research and extension

M3 Produce graduates with abilities to work in collaboration with other members of the health team in any setting

M4 Produce competent graduates who are locally relevant and globally comparable

M5 Produce competent Medical Technology graduates who possess Christian values with commitment to serve the community and uphold the integrity of our environment.

ALIGNMENT OF PROGRAM OUTCOMES WITH PROGRAM EDUCATIONAL OBJECTIVESPO DESCRIPTION PEO 1 PEO 2 PEO 3 PEO 4 PEO 5 PEO 6

PO 1 Graduates can use theoretical knowledge of clinical laboratory medicine in practical applications.

PO 2 Graduates are capable of self-management and professional growth

PO 3 Graduates are able to understand, appraise and communicate data in various forms.

PO 4 Graduates can use critical thinking to identify problems and generate solutions.

PO 5 Graduates can use the principles of interdependence as a means of realizing universal goals

PO 6 Graduates are guided by the Via, Veritas, Vita in their professional interactions.

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COURSE SYLLABUSCourse Code: MT 34

Course Title: BASIC PHARMACOLOGY and TOXICOLOGY

Pre-requisite: Bio 36 (Anatomy and Physiology) with Chem 88 (Biochemistry)

Co-requisite: none

Credit: 3 units

Contact Hours per Week: 3 hours (Lecture only) – To be divided into two meetings (1 hour and 30 minutes each)

Course Description: This course deals with the study of drugs: history and sources; physical and chemical properties; biochemical and physiologic effects; mechanism of action; distribution; metabolism; excretions, pharmacokinetics; indications; side and adverse reactions and drug interactions. Emphasis is on therapeutics and drugs of abuse. Toxicology is the study of poisons with emphasis on classification, action, regulations on dispensing and use, isolation and quantitative estimation in biological specimens. It also covers the importance, principles and application of therapeutic drug monitoring. Emphasis is on therapeutics and drugs of abuse.

CO DESCRIPTION PO1 PO2 PO3 PO4 PO5 PO6

CO 1

At the end of the course, the student will be able to:

acquire knowledge pertaining to the fate of drugs in the body from the point of entry up to the excretion process;

CO 2 explain basic concepts of pharmacokinetics, pharmacodynamics;

CO 3 present a basic rationale in understanding drug therapy;

CO 4 identify the major drugs of abuse;

CO 5 demonstrate an understanding of the adverse health effects of drug

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abuse by discussing the major clinical symptoms caused by each drug;

CO 6 enumerate the different tests that can be performed to detect the presence of drugs and drug metabolites in a patient’s sample;

CO 7 understand the principles behind each laboratory test that can be used;

CO 8 list laws and government agencies responsible for regulating and governing their use of drugs;

CO 9 and, manifest the following values: integrity, critical thinking, honesty, empathy and value for life.

BASIC PHARMACOLOGY and TOXICOLOGY LECTURE LEARNING PLAN

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COURSE LEARNING PLAN

COURSE COVERAGE PRELIMS

Wee

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UNIT EXPECTED OUTCOMES (UEO)

COURSE CONTENT

DURA

TIO

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VALUES DEPLOYED

TEACHING-LEARNING ACTIVITIES (TLA))

ASSESSMENT TASKS (AT)

RESOURCESTEACHING LEARNING ASSESSMENT TOOL

1 For the Introduction to Basic Pharmacology, at the end of the lecture, the student will be able to:

1. discuss extensively and comprehensively the different key concepts which encompass the science of pharmacology.

2. state correctly how various drugs are administered to the body

3. discuss extensively how these drugs exert their effects on their target sites

4. discuss comprehensively how drugs are metabolized and eliminated from the body

5. enumerate concisely different methods of increasing drug potency

6. discuss concisely the causes of side-effects after drug administration

1. Introduction to Basic Pharmacology1.1. General Principles of Pharmacology

1.1.1. Introduction1.1.2. Definition of Terms1.1.3. Nature of Drugs1.1.4. Physical and Chemical Properties

1.2. Principles of Pharmacodynamics1.2.1. Mechanism of Drug Action1.2.2. Pharmacologic Effects1.2.3. Drug Receptors

1.3. Principles of Pharmacokinetics1.3.1. Dynamics of Drug Absorption, Distribution and Elimination1.3.2. Bioavailability1.3.3. Routes of Administration1.3.4. Drug Distribution1.3.5. Elimination and Drug Excretion

1.4. Biotransformation1.5. Principles of Therapeutics

1.5.1. Enhancement of Drug Effects1.5.2. Adverse Drug Reaction1.5.3. Drug Toxicity

November Lecture-Discussion

Quizzes

Take home Assignments

Class participation

Assignments

– to be passed the following class lecture.

Answer Key

2 For Autonomic Pharmacology, at the end of the lecture the student will be able to:

1. discuss simply and comprehensively the basic concepts and functions of the

1.6. Autonomic Pharmacology1.6.1. Cholinoceptor-Activating & Cholinoesterase Inhibiting Drugs

1.6.1.1. Direct-Acting Cholinoceptor Stimulant1.6.1.1.1. Pharmakokinetics1.6.1.1.2. Pharmacodynamics

1.6.1.2. Indirect-Acting Cholinoceptor Stimulant1.6.1.2.1. Pharmakokinetics

November Lecture-Discussion

Quizzes

Quizzes

– to be performed during the scheduled lecture hours

Answer Key

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autonomic nervous system2. enumerate briefly and correctly

pathologies which encompass the autonomic nervous system

3. differentiate precisely how these disorders vary from one another

4. enumerate completely and accurately the different drugs which can be used for disorders of the autonomic nervous system

5. categorize and differentiate correctly the drugs used for the autonomic nervous system

6. Discuss accurately, correctly and comprehensively how these drugs exert their effects on the human body

7. describe concisely the possible effects caused by each drug especially during cases of toxicity

8. describe correctly the pathways for metabolism and elimination of these drugs

9. discuss thoroughly how these drugs are properly administered and regulated

10. state briefly and concisely the different current findings and concepts as well as advancements in autonomic pharmacology

1.6.1.2.2. Pharmacodynamics1.6.1.3. Cholinomimetics1.6.1.4. Cholinoceptor-Blocking

1.6.1.4.1. Muscarinic Receptor-Blocking Agents1.6.1.4.2. Ganglion-Blocking Drugs

1.6.1.5. Adrenoceptor Agonists1.6.1.6. Sympathomimetic Drugs

1.6.1.6.1. Direct Acting1.6.1.6.2. Mixed Acting1.6.1.6.3. Indirect Acting

1.6.1.7. Adrenoceptor Antagonist Drugs1.6.1.7.1. Alpha-receptor (Blockers) Antagonist Drugs1.6.1.7.2. Beta-receptor (Blockers) Antagonist Drugs

Assignments

Class participation

and to be passed immediately during the said periods

Assignments


Answer Key

3 For the Pharmacology of the Cardiovascular System, at the end of the lecture the student will be able to:

1. discuss simply and comprehensively the basic concepts and functions of the cardiovascular system

2. enumerate briefly and correctly pathologies which encompass

1.7. Cardiovascular1.7.1. Anti-hypertensive Drugs

1.7.1.1. Diuretics1.7.1.2. Sympathoplegic1.7.1.3. Direct Vasodilators1.7.1.4. Angiotensin-Inhibitors

1.7.2. Vasodilators & Treatment of Angina Pectoris1.7.2.1. Nitrates & Nitrites & other Nitro-vasodilators1.7.2.2. Calcium Channel-Blocking Drugs1.7.2.3. Beta-Blocking Drugs1.7.2.4. New Agents

November Lecture Discussion

Quizzes

Assignments

Quizzes

– to be performed during the scheduled lecture hours and to be passed immediately

Answer Key

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the cardiovascular system3. differentiate precisely how these

disorders vary from one another4. enumerate completely and

accurately the different drugs which can be used for disorders of the cardiovascular system

5. categorize and differentiate correctly the drugs used for the cardiovascular system

6. discuss accurately, correctly and comprehensively how these drugs exert their effects on the cardiovascular system




10. state briefly and concisely the different current findings and concepts as well as advancements in the pharmacology of the cardiovascular system

For the Pharmacology of the Excretory (Renal) System, at the end of the lecture the student will be able to:

1. discuss simply and comprehensively the basic concepts and functions of the excretory system

2. enumerate briefly and correctly pathologies which encompass the excretory system

1.7.3. Heart Failure1.7.3.1. Digitalis1.7.3.2. Positive Inotropic Drugs1.7.3.3. Negative Inotropic Drugs

1.7.4. Arrhythmias1.7.4.1. Sodium-Channel Blockers (Class 1)1.7.4.2. Beta-Adrenoceptor-Blocking Drugs1.7.4.3. Agents that prolong the action potential

1.7.4.3.1. Amiodrone1.7.4.3.2. Dronedarone1.7.4.3.3. Vernakalant1.7.4.3.4. Sotalol1.7.4.3.5. Dofetilde1.7.4.3.6. Ibutilide

1.7.4.4. Calcium Channel-Blocking Drugs1.7.4.5. Miscellaneous antiarrhythmic agents

1.8. Renal1.8.1. Diuretic Agents

1.8.1.1. Carbonic Anhydrase Inhibitors1.8.1.2. Loop Diuretics1.8.1.3. Thiazides1.8.1.4. Potassium-sparing Diuretics1.8.1.5. Agents that alter water excretion1.8.1.6. Diuretic Combinations

Class participation

during the said periods

Assignments


Answer Key

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3. differentiate precisely how these disorders vary from one another

4. enumerate completely and accurately the different drugs which can be used for disorders of the excretory system

5. categorize and differentiate correctly the drugs used for the excretory system

6. discuss accurately, correctly and comprehensively how these drugs exert their effects on the excretory system




10. state briefly and concisely the different current findings and concepts as well as advancements in the pharmacology of the cardiovascular system

4 For drugs which act on the Smooth Muscle, at the end of the lecture the student will be able to:

1. discuss simply and concisely basic concepts and functions of the smooth muscles in the body

2. enumerate briefly and correctly disorders which can be observed in organs where smooth muscles may be located.

3. differentiate how these disorders vary from one another

4. enumerate and differentiate the

1.9. Drugs with actions on Smooth Muscle1.9.1. Vasoactive Peptides

1.9.1.1. Angiotensin Receptor Antagonist1.9.1.2. Converting Enzyme Inhibitors1.9.1.3. Renin Inihibitors1.9.1.4. Kinin Antagonists1.9.1.5. Vasopressin Agonists1.9.1.6. Vasopressin Antagonists1.9.1.7. Natriuretic Peptides1.9.1.8. Vasopeptidase Inhibitors1.9.1.9. Endothelin Antagonists1.9.1.10. Vasoactive Intestinal Peptide Agonists1.9.1.11. Neurotensin Agonists1.9.1.12. Neurotensin Antagonists

November Lecture Discussion

Quizzes

Assignments

Quizzes

– to be performed during the scheduled lecture hours and to be passed immediately during the said periods

Answer Key

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different drugs which can be used for such disorders

5. categorize and differentiate correctly the drugs used to treat disorders of the smooth muscles.

6. discuss accurately, correctly and comprehensively how these drugs exert their effects on the smooth muscles




10. state briefly and concisely the different current findings and concepts as well as advancements in the pharmacology of smooth muscle disorders

1.9.1.13. Calcitonin Gene-related Peptide Antagonists1.9.1.14. Neuropeptide Y Antagonists1.9.1.15. Urotensin Antagonists

1.9.2. Nitric Oxide1.9.3. Drugs used in Asthma

Class participation

Assignments


Answer Key

5 INTRAMURALS December

6 For the Pharmacology of the Central Nervous System, at the end of the lecture the student will be able to:

1. discuss simply and comprehensively the basic concepts and functions of the central nervous system

2. enumerate briefly and correctly pathologies which encompass the central nervous system

3. differentiate precisely how these

1.10. Central Nervous System1.10.1.Sedative-Hypnotic

1.10.1.1. Barbiturates1.10.1.2. Benzodiazepenes & Benzodiazepene antagonists1.10.1.3. Miscellaneous drugs

1.10.2.Antiseizures1.10.2.1. Benzodiazepines1.10.2.2. Tricyclics1.10.2.3. Benzodiazepines1.10.2.4. GABA derivatives1.10.2.5. Miscellaneous

1.10.3. Anesthetics1.10.3.1. General Anesthetics1.10.3.2. Local Anesthetics

December Lecture Discussion

Quizzes

Assignments

Quizzes

– to be performed during the scheduled lecture hours and to be passed immediately during the said

Answer Key

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disorders vary from one another4. enumerate completely and

accurately the different drugs which can be used for disorders of the central nervous system

5. categorize and differentiate correctly the drugs used for the central nervous system

6. discuss accurately, correctly and comprehensively how these drugs exert their effects on the central nervous system




10. state briefly and concisely the different current findings and concepts as well as advancements in the pharmacology of the central nervous system

1.10.3.2.1. Amides1.10.3.2.2. Esters

1.10.4.Skeletal Muscle Relaxants1.10.4.1. Direct Acting1.10.4.2. Centrally Acting Spasmolytic drugs1.10.4.3. Depolarizing Neuromuscular Blocking Agents1.10.4.4. Non-depolarizing Neuromuscular Blocking Agents

1.10.5. Movement Disorder Drugs (Parkinsons. etc)1.10.5.1. Levodopa1.10.5.2. Dopamine1.10.5.3. Monoamine Oxidase Inhibitors1.10.5.4. COMT Inhibitors1.10.5.5. Antimuscarinic Agents1.10.5.6. Drugs for Huntington’s Disease1.10.5.7. Drugs for Tourette’s Syndrome

1.10.6.Antipsychotic Agents1.10.6.1. Lithium1.10.6.2. Phenothiazines1.10.6.3. Thioxanthene1.10.6.4. Butyrophenone1.10.6.5. Atypical Drugs1.10.6.6. New Agents for Bipolar Disorder

1.10.7.Antidepressants1.10.7.1. Selective Serotonin Reuptake Inhibitors1.10.7.2. Serotonin –Norepinephrine Reuptake Inhibitors1.10.7.3. Tricyclic Antidepressants1.10.7.4. 5-HT2 Antagonists1.10.7.5. Tricyclics and Unicyclics1.10.7.6. Monoamine Oxidase Inhibitors

Class participation

periods

Assignments


Answer Key

7 For the Pharmacology of the Vascular System, at the end of the lecture the student will be able to:

1. discuss simply and comprehensively the basic concepts and functions hematologic cells and components needed for coagulation

2. enumerate briefly and correctly anemias and coagulation disorders of the blood

3. differentiate how these disorders

1.10.8.Drugs used to treat Hematologic Disorders1.10.8.1. Drugs for Anemia

1.10.8.1.1. Iron1.10.8.1.2. Iron Chelators1.10.8.1.3. Vitamin B12

1.10.8.1.4. Folic Acid1.10.8.1.5. Erythrocyte-stimulating Agents1.10.8.1.6. Myeloid growth factors

1.10.8.2. Drugs for Disorders in Coagulation1.10.8.2.1. Thrombin Inhibitors

1.10.8.2.1.1. Indirect Thrombin Inhibitors1.10.8.2.1.1.1. Heparin

1.10.8.2.1.2. Direct Thrombin Inhibitors1.10.8.2.1.2.1. Parenteral Direct Thrombin

December Lecture Discussion

Quizzes

Assignments

Class participation

Quizzes


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vary from one another4. enumerate completely and

accurately different drugs which can be used for anemias and coagulation disorders

5. categorize and differentiate correctly the drugs used for anemias and coagulation disorders

6. discuss accurately, correctly and comprehensively how these drugs exert their effects on these disorders




10. state briefly and concisely the different current findings and concepts as well as advancements in the pharmacology of the central nervous system

For the Pharmacology of Dyslipidemias and Anti-inflammatory Drugs, at the end of the lecture the student will be able to:

1. discuss simply and comprehensively basic concepts of dyslipidemias and inflammation

2. enumerate correctly the various

Inhibitors1.10.8.2.1.2.2. Oral Direct Thrombin Inhibitors

1.10.8.2.2. Pharmacology of Fibrinolytic Drugs1.10.8.2.3. Pharmacology of Anti-platelet Drugs1.10.8.2.4. Pharmacology of Drugs that prevent clot

formation1.10.8.2.5. Drugs used in Bleeding Disorders1.10.8.2.6.Megakaryocyte growth factors for decreased

platelet counts

1.11. Dyslipidemias1.11.1.Competitive Inhibitors of HMG-CoA Reductase (Reductase

Inhibitors; “Statins”)1.11.2.Nicotinic Acid (Niacin)1.11.3.Fibric Acids (Fibrates)1.11.4.Bile Acid Binding Resins1.11.5.Inhibitors of Sterol Absorption

1.12. Anti-inflammatory Drugs1.12.1. Non-steroidal Anti-inflammatory Drugs1.12.2. Non-opioid Analgesics1.12.3.Drugs used in Gout

Assignments


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types of dyslipidemias and inflammation

3. differentiate concisely how various dyslipidemias vary from one another, and how inflammation is initiated in the body

4. enumerate accurately the different drugs which can be used for each type of dyslipidemia and inflammation

5. differentiate and categorize the different drugs used to treat dyslipidemias and inflammation

6. discuss accurately, correctly and comprehensively how these drugs exert their effects



9. state briefly and concisely the different current findings and concepts as well as advancements in the treatment of dyslipidemias and inflammation

8 For Endocrinology Pharmacology, at the end of the lecture the student will be able to:

1. discuss simply and comprehensively the basic concepts and functions of Endocrine System

2. enumerate briefly and correctly disorders of the Endocrine System

3. differentiate how these disorders vary from one another

4. enumerate completely and

1.13. Drugs used to treat Disorders of the Endocrine System1.13.1.Hypothalamic & Pituitary1.13.2.Thyroidal1.13.3.Corticoids1.13.4.Pancreatic and drugs used in the management of Diabetes1.13.5.Reproductive1.13.6.Mineral Homeostasis

January Lecture Discussion

Quizzes

Assignments

Quizzes


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accurately different drugs which can be used for disorders of the Endocrine System

5. categorize and differentiate correctly the drugs used for disorders of the Endocrine System

6. discuss accurately, correctly and comprehensively how these drugs exert their effects




10. state briefly and concisely the different current findings and concepts as well as advancements in the pharmacology of Endocrine System

Class participation

Assignments


9 For Chemotherapy leading to General Antibiotics, at the end of the lecture the student will be able to:

1. discuss correctly the basic concepts of chemotherapy

2. discuss concisely the basic concepts of bacterial infections

3. enumerate and differentiate correctly the various types of bacterial infection causing agents

4. enumerate and differentiate accurately the different drugs which can be used for each kind of bacterial infection

1.14. Chemotherapeutic Drugs1.14.1.General Concepts1.14.2.Antimicrobial

1.14.2.1.General Antibiotic1.14.2.1.1.Beta-lactams & Cell Wall Acting Drugs

1.14.2.1.1.1. Penicillins1.14.2.1.1.2. Cephalosporins1.14.2.1.1.3. Carbapenems1.14.2.1.1.4. Monobactams1.14.2.1.1.5. Glycopeptide1.14.2.1.1.6. Lipopeptide

1.14.2.1.2.Drugs that Prevent Protein Synthesis1.14.2.1.2.1. Tetracyclines1.14.2.1.2.2. Macrolides1.14.2.1.2.3. Lincosamide1.14.2.1.2.4. Streptogramins1.14.2.1.2.5. Chloramphenicol


Quizzes

Assignments

Class participation

Quizzes


Assignments

14


5. discuss accurately, correctly and comprehensively how these drugs exert their effects on the agents of infection

6. describe concisely the possible unwanted effects on the host body as caused by each drug especially during cases of toxicity


8. discuss accurately and correctly how a chemotherapeutic agent is chosen for treatment of a specific bacterial infection


10. state briefly and concisely the different current findings and concepts as well as advancements in the pharmacology of bacterial infections

1.14.2.1.2.6. Oxazolidones1.14.2.1.2.7. Aminoglycosides1.14.2.1.2.8. Spectinomysin

1.14.2.1.3. Inhibitors of Folic Acid Synthesis1.14.2.1.3.1. Sulfonamides1.14.2.1.3.2. Trimethoprim

1.14.2.1.4. Inhibitors of DNA Synthesis1.14.2.1.4.1. Fluoroquinolones

1.14.2.1.5.Miscellaneous Antibacterial drugs (Urinary tract infection)


10 For Antimycobacterial and Antiparasitic chemotherapeutic agents, at the end of the lecture the student will be able to:

1. discuss concisely the basic concepts of mycobacterial and parasitic infections

2. enumerate and differentiate correctly the various types of mycobacterial and parasitic infection causing agents

3. enumerate and differentiate accurately the different drugs which can be used for each kind of mycobacterial and parasitic infection

1.15.1.2.Antimycobacterial1.15.1.2.1.1. Isoniazid1.15.1.2.1.2. Rifampicin1.15.1.2.1.3. Pyrazinamides1.15.1.2.1.4. Ethambutol1.15.1.2.1.5. Streptomycin1.15.1.2.1.6. Dapsone & other Drugs for Leprosy1.15.1.2.1.7. Drugs for other Mycobacterial infections

1.15.1.3.Antiparasitic1.15.1.3.1.1. Anti-protozoal

1.15.1.3.1.1.1. Anti-malarial1.15.1.3.1.1.2. Drugs for Leishmania1.15.1.3.1.1.3. Drugs for Trypanosomiasis1.15.1.3.1.1.4. Drugs for Amebiasis & other

intestinal infections caused by protozoans

1.15.1.3.1.1.5. Drugs for Trichomoniasis


Quizzes

Assignments

Class participation

Quizzes


Assignments

15


4. enumerate and differentiate accurately the different drugs which can be used for each kind of mycbacterial and parasitic infection




8. discuss accurately and correctly how a chemotherapeutic agent is chosen for treatment of a specific mycobacterial or parasitic infection


10. state briefly and concisely the different current findings and concepts as well as advancements in the pharmacology of mycobacterial and parasitic infections

1.15.1.3.1.1.6. Other protozoal infections1.15.1.3.1.2. Anti-helminthic

1.15.1.3.1.2.1. Drugs for Nematodes1.15.1.3.1.2.1.1. Ascariasis1.15.1.3.1.2.1.2. Trichuriasis1.15.1.3.1.2.1.3. Pin-worm infections

1.15.1.3.1.2.2. Drugs for Cestodes1.15.1.3.1.2.2.1. Tapeworms

1.15.1.3.1.2.2.1.1. Fish tapeworms1.15.1.3.1.2.2.1.2. Beef tapeworms1.15.1.3.1.2.2.1.3. Pork tapeworms1.15.1.3.1.2.2.1.4. Neurocyticercosis1.14.2.1.5.1.1.1.1. Other tapeworm

infections1.14.2.1.5.1.1.2. Flatworms/flukes

1.14.2.1.5.1.1.2.1. Schistosomiasis1.14.2.1.5.1.1.2.2. Other flukes


11 For Antiviral and Antifungal chemotherapeutic agents, at the end of the lecture the student will be able to:

1. discuss concisely the basic concepts of fungal and viral infections

2. enumerate and differentiate correctly the various types of fungal and viral infection

2.15.1.4.Antifungal2.15.1.4.1.Polyene Macrolide2.15.1.4.2.Pyramidine Analog2.15.1.4.3.Azoles2.15.1.4.4.Echinocandins2.15.1.4.5.Allylamine

2.15.1.5.Anti-viral Agents


Quizzes

Assignments

Quizzes

– to be performed during the scheduled lecture hours and to be passed immediately

16


causing agents3. enumerate and differentiate

accurately the different drugs which can be used for each kind of fungal and viral infection

4. enumerate and differentiate accurately the different drugs which can be used for each kind of fungal and viral infection




8. discuss accurately and correctly how a chemotherapeutic agent is chosen for treatment of a specific fungal or viral infection


10. state briefly and concisely the different current findings and concepts as well as advancements in the pharmacology of fungal and viral infections

Class participation

during the said periods

Assignments


12 For Cancer Chemotherapy and Immuno-pharmacology, at the end of the lecture the student will be able to:

1. discuss simply and concisely the mechanism by which malignancies occur in the

3.15.2.Cancer Chemotherapy3.15.2.1. Various chemotherapeutic agents3.15.2.2. Mode of action3.15.2.3. Drug metabolism and

3.16. Immuno-pharmacology3.16.1.Clinical uses of:

3.16.1.1.Immunosuppressive drugs3.16.1.2.Monoclonal antibodies

February Lecture Discussion

Quizzes

Quizzes

– to be performed during the scheduled lecture hours

17


human body2. discuss concisely the concepts

of autoimmunity and other disease of the immune system

3. enumerate and differentiate concisely the various malignancies and immune disorders in the human body.

4. enumerate and differentiate correctly the different drugs which can be used for each kind of immune disorder and cancer.

5. discuss accurately and correctly how a chemotherapeutic agent is chosen for treatment of a specific malignancy and immune disorder



8. state briefly and concisely the different current findings and concepts as well as advancements in the field of cancer pharmacology and immuno-pharmacology

Assignments

Class participation

and to be passed immediately during the said periods

Assignments


13 MIDTERM EXAMINATION

14 For topics Introduction to Toxicology leading up to drug testing, at the end of the discussion the student will be able to:

1. discuss comprehensively the different general concepts which encompass the science of Toxicology.

4. Toxicology4.1. General Concepts

4.1.1. Toxic Dose4.1.2. Lethal Dose

4.2. Drug Testing4.2.1. Review of Republic Act 91654.2.2. Pre-analysis

4.2.2.1. Pre-collection specifications and considerations4.2.2.2. Specimen Collection (Chain of Custody)4.2.2.3. Specimen Transportation


Quizzes

Quizzes

– to be performed during the scheduled lecture hours and to be passed

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2. discuss comprehensively the foundations of drug testing in the Philippines as based on the RA 9165.

3. enumerate correctly the procedural protocol for sample collection for drug testing.

4. discuss comprehensively the concept and significance of the Chain of Custody.

5. Enumerate concisely possible sources of error which may take place during the process of sample collection and transportation

6. Discuss thoroughly and accurately the analytical process of drug testing

7. State correctly the principles encompassing each type of laboratory test used in the determination and measurement of drugs in clinical samples.

8. State correctly the manner of reporting and state briefly and concisely other specifications concerned with the analysis of drugs.

9. Enumerate concisely possible sources of error in the post-analytical phase of drug testing.

4.2.3. Sources of Error4.2.4. Analysis

4.2.4.1. Procedure, Principles, and Methodology for testing of:

4.2.4.1.1. Recreational Drugs4.2.4.1.2. Environmental and Industrial Toxicity4.2.4.1.3. Miscellaneous Drugs and Toxins4.2.4.1.4. Sources of Error

4.2.5. Post-Analysis4.2.5.1. Reporting and Specifications

4.2.6. Sources of Error

Assignment

Class participation

immediately during the said periods

Assignments


15 February

16 For Toxicology of Recreational Drugs, at the end of the discussion the student will be able to:

1. enumerate and categorize various recreational drugs and other drugs of abuse.

4.3. Recreational Drugs4.3.1. Alcohols4.3.2. Cocaine4.3.3. Marijuana4.3.4. Hallucinogens4.3.5. Opiates4.3.6. Designer Drugs


Quizzes

– to be performed during the scheduled

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2. know how these various drugs are administered into the body.

3. know how these drugs exert their effects on their target sites

4. know how these drugs are metabolized and eliminated from the body.

5. determine diseased states or states of “high”, caused by specific agents, as based on symptomatology and laboratory findings.

6. know how these states of toxicity can be reversed or treated.

4.3.7. New modern agents Quizzes

Assignments

Class participation

lecture hours and to be passed immediately during the said periods

Assignments


16 For Toxicology of Specific industrial and environmental agents, at the end of the discussion the student will be able to:

1. enumerate various environmental agents and or poisons that may be encountered in different areas and materials

2. know how these various environmental agents/poisons are administered into the body.

3. know how these drugs exert their effects on their target sites

4. know how these drugs are metabolized and eliminated from the body.

5. determine diseased states, caused by specific agents, based on symptomatology and laboratory findings.

6. state the principles of various laboratory tests which are used in detecting drugs and or drug metebolites in the patient

4.4. Specific Agents4.4.1. Industrial and Environmental Agents

4.4.1.1. Lead4.4.1.2. Mercury4.4.1.3. Arsenic4.4.1.4. Carbon Monoxide4.4.1.5. Toxins and Poisons of various sources

4.4.1.5.1. Mammalian4.4.1.5.2. Reptilian4.4.1.5.3. Arachnid and Insects4.4.1.5.4. Plant based4.4.1.5.5. Microbial

March Lecture Discussion

Quizzes

Assignment

Class participation

Quizzes


Assignments


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sample.7. know how these states of toxicity

can be reversed or treated.

17 SPECIAL CASE ANALYSIS PRESENTATION FOR PHARMACOLOGY AND TOXICOLOGY

March Lecture Discussion

Quizzes

Assignment

Class participation

Quizzes


Assignments


18 FINAL EXAMINATION WEEK

Major References:

Basic and Clinical Pharmacology 13th Edition by Bertram G. Katzung

Pharmacology 6th Edition by Karen Whalen

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Other Basic Pharmacology References can also be used

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Basic and Clinical Pharmacology 13 · Web viewFor the Pharmacology of the Central Nervous System,...

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Transcript of Basic and Clinical Pharmacology 13 · Web viewFor the Pharmacology of the Central Nervous System,...