BAPI .

• BAPI

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Bapineuzumab

1 'Bapineuzumab' is a humanized monoclonal antibody that acts on the

nervous system and may have potential therapeutic value for the

treatment of Alzheimer's disease and possibly glaucoma


Bapineuzumab

1 Bapineuzumab has been shown to recognise the extreme N-terminal 5 residues of Aβ peptide in a helical conformation (4HIX.pdb) stabilized

by internal hydrogen bonds involving the first three amino acids.


Bapineuzumab

1 Bapineuzumab is an antibody to the beta-amyloid (Aβ) plaques that are believed to

underlie Alzheimer's disease neuropathology. In previous clinical trials for

vaccination against human beta amyloid, called AN-1792, patients with Alzheimer's

disease using active immunization had positive outcomes with removal of plaques,

but 6% of subjects developed aseptic meningitis and the trial was stopped.


Bapineuzumab

1 Bapineuzumab was being co-developed by the pharmaceutical companies Élan and Wyeth and

entered Clinical trial#Phase III|Phase III trials in December 2007.


Bapineuzumab

1 In patients receiving the highest dose, e.g. 2mg, MRI scans showed an

accumulation of water in brain tissue (vasogenic edema). No health risks were found in subjects receiving either 0.5 or

1mg of bapineuzumab. Patients who have been receiving or have been

scheduled to receive the highest dose will be either removed from the trials or

switched to lower doses.


Bapineuzumab

1 On August 6, 2012, Pfizer Inc. and Johnson Johnson said they are

ending development of an intravenous formulation of

bapineuzumab. Testing showed the drug did not work better than

placebo in two late-stage trials in patients who had mild to moderate

Alzheimer's disease.


Bapineuzumab

1 Élan announced that Johnson Johnson, on July 16, 2013, had

discontinued Phase 2 testing of the Subcutaneous injection|

subcutaneous formulation of bapineuzumab.[http://www.elan.com/company/about_us Phase 2 testing of

the subcutaneous formulation of bapineuzumab is to be discontinued.] Elan Corporation. Retrieved 2013-08-

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Bapi Tutul

1 'Bapi Tutul' are a Hindi film composer duo consisting of Bapi and his

younger brother Tutul. They have written the scores for films such as

Sarkar (film)|Sarkar Sarkar Raj, Khosla Ka Ghosla and many more.


Bapi Tutul - Early life

1 Bapi is known for his specialization in Guitar

while Tutul in Piano


Bapi Tutul - Connection with Music

1 Bapi and Tutul were hugely influenced by their mother due to her interest in music. Their initial training in Classical Music was given by her. However, the quest to learn

western music brought the two brothers to Mumbai. Here, they met Rodrcik Bismark and learnt western music from him during

1994 till 1999. During this period, Bapi Tutul picked up small music assignments

like ad jingles teaching music to students.


Bapi Tutul - Discography

1 * Sarkar Raj (2008).http://www.planetradiocity.com/musicreporter/celebrity-interview-details/Composer-duo-Bapi-Tutul-are-

back-with-Sarkar-Raj/138


Bapi Tutul - Awards Accolades

1 Bapi-Tutul were nominated in the Best Background Score Category for 15th Annual

Star Screen Awards


Postalveolar - Point of tongue contact (laminal, apical, subapical)

1 Apical and subapical articulations are always tongue-up, with the tip of

the tongue above the teeth, while laminal articulations are often

tongue-down, with the tip of the tongue behind the lower teeth.



1 The upward curvature of the tongue tip to make apical or subapical

contact renders palatalization more difficult, so domed (palato-alveolar)

consonants are not attested with subapical articulation, and fully

palatalized (e.g



1 Subapical retroflex sounds are often palatal (and vice-versa); such sounds

occur particularly in the Dravidian languages


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