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www.monash.edu.au Bachelor of Medical Science Information Session 20 September 2005 Metabolic Cardiolgy Professor David Kaye
Transcript of baker-institute-pres..
www.monash.edu.au
Bachelor of Medical ScienceInformation Session20 September 2005
Metabolic CardiolgyProfessor David Kaye
www.monash.edu.au
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Sample of Project Titles
• Effects of atrial fibrillation on heart function• Properties of circulating stem cells in heart
failure• Endothelial function in diabetes: importance of
arginine metabolism• Ischaemia-reperfusion damage: importance of
arginine metabolism• Predictors of heart failure progression• Determinants of implantable defibrillator usage
in heart failure patients
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Interests and Strengths of the Department
• Focus on clinical cardiology• Utilization of unique methodologies• Translational approach to clinical
questions• Integration with leading heart failure
research team
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Contact Details of Supervisor/s
Name:
Location Details:
Phone Numbers:
Email:
Name:
Location Details:
Phone Numbers:
Email:
Name:
Location Details:
Phone Numbers:
Email:
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Bachelor of Medical ScienceInformation Session20 September 2005
Clinical PhysiologyBaker Heart Research Institute
A/Prof Bronwyn Kingwell
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Sample of Project Titles
• Type 2 Diabetes– Novel therapeutics to increase glucose
and fat metabolism
• Unstable Coronary Syndromes– Identification of novel predictors of
unstable coronary heart disease
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Interests and Strengths of the Department
• Translational Human Research– Human primary cell culture
• In Vivo Human Physiology– Metabolism– Trans-lesional coronary blood sampling– IVUS
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Contact Details of Supervisor/s
Name: Dr Stephen DuffyLocation Details: Cardiovascular Medicine
Head, Cardiology General ServicesPhone Numbers:9276 2732Email: [email protected]
Name: A/Prof Bronwyn KingwellLocation Details: Baker Heart Research Institute
Head, Clinical Physiology Cardiovascular Medicine, Alfred Hospital
Phone Numbers: 9276 3261Email: [email protected]
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Bachelor of Medical ScienceInformation Session20 September 2005
Molecular Pharmacology Laboratory, Baker Heart Research InstituteDr Rebecca H Ritchie
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Pharmacology of cardiac protection
Two projects are available• (1): ANNEXIN-1 REDUCES ISCHAEMIC
DAMAGE IN THE HEART
• (2): CARDIAC COMPLICATIONS OF TYPE 2 DIABETES
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Interests and Strengths of the Molecular Pharmacology Laboratory
• identifying new treatments to ↓ damage to the heart: – ischaemia-reperfusion injury – cardiac hypertrophy – cardiac complications of diabetes
• our treatments are based on antioxidant approaches, studied in cell culture, isolated hearts & in vivo
• Use of cutting edge techniques• The ultimate goal of our research is to provide the
necessary impetus to move towards better prevention of human heart failure, whether resulting from cardiac hypertrophy, diabetes, or infarction.
heart failure
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Contact Details of Supervisor
Name: Dr Rebecca H Ritchie
Molecular Pharmacology Laboratory, Molecular Neurocardiology
Location Details:
3rd floor, Baker Heart Research Institute
75 Commercial Rd Melbourne (next door to the Alfred Hospital)
Phone Number: (03) 8532 1392
Email: [email protected]
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Bachelor of Medical ScienceInformation Session20 September 2005
Oxidative Stress GroupDr. Judy de Haan
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Sample of Project Titles
• Does over-expression of the antioxidant Glutathione peroxidase-1 protect against atherosclerosis in the ApoE-knockout mouse?
• Can Ebselen, an antioxidant and Gpx1 mimic, reduce diabetes-associated atherosclerosis in the ApoE-/- mouse?
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Interests and Strengths of the Department
• Major interest of group is in free radical-mediated pathogenesis, with a major focus on atherosclerosis.
• Mouse models available to test our hypotheses.
• Lab has more than 15 yrs experience in free radical biology.
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Contact Details of Supervisor/s
Name:
Location Details:
Phone Numbers:
Email:
Name:
Location Details:
Phone Numbers:
Email:
Name: Dr. Judy de HaanLocation Details: Baker Heart Research Institute,
Commercial Road, MelbournePhone Numbers: 85321195Email: [email protected]
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Bachelor of Medical ScienceInformation Session20 September 2005
Clinical PhysiologyBaker Heart Research InstituteDept head: A/Prof Bronwyn Kingwell; Senior Researcher: Dr Barbora de Courten
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Project Title
• Will reduction of dietary advanced glycation end-products (AGEs) reduce chronic low-grade inflammation and improve insulin sensitivity in humans?
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Interests and Strengths of the Department
• Predictors of type 2 diabetes and diabetes complications
• Inflammation/low grade activation of the immune system
• New targets for therapy• In vivo human physiology/pathophysiology• Gold standard measurements for insulin
sensitivity and secretion in humans• Biochemical analyses of blood and tissues
including PCR, ELISA and immunohistochemistry
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Contact Details of Supervisor/s
Name: Barbora de Courten, MD
Location Details: Barker Heart Research Institute
Phone Numbers: 03 85321353
Email: [email protected]
