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    Journal of Pharmacognosy and Phytotherapy Vol. 3(1), pp. 1-7, January 2011Available online at http://www.academicjournals.org/jppISSN 2141-2502 2011 Academic Journals

    Review

    Antidiarrhoeal activity of aqueous leaf extract ofMomordica charantiain rats

    Bakare R. I.*, Magbagbeola O. A., Akinwande A. I., Okunowo O. W. and Green M.

    Department of Biochemistry, College of Medicine, University of Lagos, Idi-Araba, Lagos State, Nigeria.

    Accepted 9 December, 2010

    Momordica charantiaLinn (Cucurbitaceae) is a medicinal herb, whose common name bitter melon, hasbeen reported to possess antidiabetic property. However, its antidiarrhoeal potential is still unknown.The antidiarrhoeal activity of aqueous leaf extract of M. charantia (MC) was evaluated on castor oil-induced diarrhoea, gastrointestinal transit, intestinal fluid accumulation and gastric emptying in rats.The aqueous extract of the plant showed inhibitory activity against castor oil induced diarrhoea. Asignificant reduction (p< 0.05) in the gastrointestinal motility in charcoal meal test in rats was observed.The extract decreased volume of intestinal secretion induced by castor oil with a significant effect ( p


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Alan Ji, Lola Bakare, Risa Kuamochi, Justine Singer-Kaufold.

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