Background White (2)
of 1
Transcript of Background White (2)
-
8/16/2019 Background White (2)
1/1
Role of LACTULOSE in treating
HEPATIC ENCEPHALOPATHY
• Ammonia (NH3) contributes to symptoms of
Hepatic Encephalopathy by crossing Blood-Brain
Barrier
• Lactulose (nonabsorbable disaccharide) is
metabolized by intestinal bacteria into Lactic
Acid other organic acids
• Acidic en!ironment in intestines helps in
conversion of Ammonia(NH3 into
Ammoni!m(NH"# " Ioni$ation of Ammonia
re%!ces a&sor'tion from gut lumen
• Acidic en!ironment in the gut also acts to reduce
the brea#do$n of other nitrogen-containing
compounds to ammonia
