Ayurvedic Drugs Found Effective in HIV/AIDS

Dr. Pawan Kumar Godatwar

National Institute of Ayurveda

Jaipur

India

N= 1 Type of Study: Case Report Specific Treatment: Turmeric extract

standardized for 95% curcumin Route of Adminstration: Oral (capsule) Dose: 900 mg tid Treatment duration/follow-up duration: One

week Outcome Measure: P24 antigen level Type of Control: ND Statistical Significance Level: Statistics ND, but

substantial drop in p24 antigen

N= 173 Type of Study: Evaluation study Specific Treatment: SPV-30 (Boxwood extract) Route of Adminstration: oral Dose: ND Treatment duration/follow-up duration: Six months Outcome Measure: plasma HIV RNA, cd 4 and cd8

count Type of Control: ND Statistical Significance Level: 63% had decreased

plasma HIV RNA, 41% had increases in CD4, 52% had increases in CD8 counts

N= 145 Type of Study: Randomized double blind multicenter trial Specific Treatment: SPV30- Extract of leaves and stems of Boxus

sempervirens Route of Adminstration: Oral (capsule) Dose: Group 1: 330mg tid, Group 2: 660 mg tid Treatment duration/follow-up duration: 38 weeks with check up

every 4 weeks Outcome Measure: Safety and efficacy: CD4 count and plasma

HIV RNA Type of Control: Two different doses (990 mg/d and 1980 mg/d) of

SPV30 vs placebo Statistical Significance Level: plasma HIV RNA increase occurred

less often in the SPV30 990 mg gp than the 1980 mg gp or placebo gp (p=0.029) No patient in SPV 30 990 mg gp progressed to disease compared to 4 in placebo gp (p=0.042)

N= 17 Type of Study:Phase 1 clinical trial Specific Treatment: Andrographolide from

andrographis paniculata Route of Adminstration: Oral Dose: 5 mg/kg tid for 3 wks, 10 mg/kg tid for 3 wks,

then 20 mg/kg tid for 3 wks Treatment duration/follow-up duration: 9 weeks Outcome Measure: Safety and tolerability Type of Control: Healthy volunteers Statistical Significance Level: Significant rise in mean

CD4 of HIV subjects after 10 mg/kg (P=0.002)

N= 26 with HIV associated sensory neuropathy Type of Study: Multi-center, controlled randomized, double

blinded clinical trial Specific Treatment: Capsaicin (90.075%) plus usual analgesic

therapy Route of Adminstration: Topical Dose: cream applied qid Treatment duration/follow-up duration: 4 weeks Outcome Measure: Pain intensity, pain relief, sensory

perception, quality of life, mood and function Type of Control: Placebo cream plus usual analgesic therapy Statistical Significance Level:Subjects in the intervention

arm had higher pain scores after 1 wk of treatment (P<0.042). All other effects NS.

N= 36 Type of Study: Open label pilot study Specific Treatment: Immu-25: 100 mg each of ocimum sanctum,

withania somnifera, emblica officinalis and tinospora cordifolia Route of Adminstration: Oral (capsule) Dose: 2 caps bid Treatment duration/follow-up duration: 18 months long, evaluated

at monthly intervals Outcome Measure: General signs and symptoms, development of

infections, weight gain and plasma HIV RNA Type of Control: NA Statistical Significance Level: General symptoms significantly

decreased after 12 mos., body weight increased (P<0.001), Overall significant reduction in plasma HIV RNA and increase in CD4 cell count (P<0.001)

N= 10 ART-naive patients with AIDS Type of Study: Pilot clinical trial Specific Treatment: Extract of Neem leaves (Azadirachta

indica A. Juss) Route of Adminstration: Oral (capsule) Dose: 1000 mg qd Treatment duration/follow-up duration: Treatment for 30

days/ followed up for one month bi weekly to monitor conditions

Outcome Measure: Changes in hemoglobin, CD4 count erythrocyte sedimentation rate pre- post

Type of Control: Pre post study Statistical Significance Level: Changes in Hemoglobin

(P<0.05), bodyweight (p>0.05), CD4 count (P<0.01), and ESR (P<0.01)

In conclusion of a landmark review of 21 laboratory studies, 17clinical studies, and 6 previous reviews of the literature out of 206original articles from 1986 to Oct 2008 reviewed, M Fritts et al of Samueli Institute, Alexandria, USA propose that:

Consideration be given by the Indian Medical Association to recognizing TIMH providers and to training them in providing coordinated care (in collaboration with their allopathic counterparts) to the millions of HIV infected patients for whom they already provide care.

Furthermore, we propose that a sound, evidence-based model of integrative HIV/AIDS care that is based on enhanced cross-training and collaboration between TIMH and allopathicpractitioners and solid safety and effectiveness data, has the potential for improving health outcomes among HIV positive individuals in India.

M Fritts, CC Crawford, D Quibell, A Gupta, WB Jonas, I Coulter and SA Andrade; Traditional Indian medicine and homeopathy for HIV/AIDS: a review of the literature, AIDS Research and Therapy 2008, 5:25

1. Pradeepkumar et al (1995) confirmed the usage of Rasayanas as immunomodulators. Effect of Rasayanas on Cellular Immunity of Mice, 1995, Pradeep Kumar et al

2. Singh J. P. et al reported ethnic aspects of Tinospora plant, taken as gulunch by Bihar tribals used as tonic and growth promoter. Ethnic aspects of Tinospora plant in Bihar 1996, J. P. Singh et al

3. Abeysekara A. M. et al isolated an immunomodulatory C-Glucosylated propelargonidin from the unripe fruit of Aeglemarmelos. An immunomodulatory C. - Gluco sylated Propelargonidinfrom unripe fruit of Aegle mermelos, 1996, Abeysekara et al

4. Thatte H. et al reported immunostimulatory properties in Tinosporacordifolia,The potential role of Tinospora cordifolia in Cancer therapeutics, 1998, Thatte U. et al

5. Patil M.A. has suggested Anti HIV activity of Nimba and Karavellam,; Sapta Dhatu Kala Jwara and HIV infections /AIDS - A correlation, 1998, Patil M.A.

6. Hoffiman observed Aloe berbedensis concentration increasing T-4 lymphocytes; New Protocol for the treatment of AIDS and Cancer utilizing Aloe vera and Cesium chloride, 1998, Hoffiman A. J.

7. Kulkarni P. H. suggests chyavanprash and Raktavardhak useful as adjuvant treatment for AIDS and Cancer; Role of Diet in treatment of Cancer and AIDS, 1998, Kulkarni P. H.

8. Ameen M. M. opines, by behavioural changes AIDS can be totally controlled; An ideal model for control of AIDS, 2000, Ameen M.M.

9. Bhallatak granules has shown efficacy in management of AIDS Vyas et al.; Clinical Study on AIDS according to Ayurveda and its management with certain Rasayana drugs, 1995, VyasV. et al.(I.P.G.T&R.A)

10. Ayurvedic compound drug preparations Ojovardhak Avaleha comprising of certain rasayanadrugs enhanced the non specific immunity so that progress of disease is controlled; A study on Ayurvedic aspect of Acquired immune deficiency syndrome and its management with Ayurvedic drugs, 2000, Godatwar P; K. etal.(I.P.G.T&R.A)

11. M. Kesavan et al. observed the improvement in CD4 cells and CD4 and CD8 ratio percent with compound drug preparation made of Jeevaneeya, Brimhaneeya and Pachaneeyaqualities; The efficacy of Ayurveda Drug formulation against HIV /AIDS disease, 2000, Kesavan M. et al

12. A clinical study to assess the Ayurvedic treatment modalities in patients undergoing anti-tuberculous treatment with HIV +VE, 1999, Suresh K.R., Ayurvedic College, Trivandrum

13. Sudha Menon UP, Baghel MS, Pandya KN, A Clinical Study On Aetiopathogenesis Of 'AIDS' And Assessment On The Efficacy Of 'Indukanta Ghrita' In Its Symptom 'Jwara' (Pyrexia); MD Thesis, IPGTRA, Jamnagar, 2003

Adhaki Agaru Ahiphena Amalaki

Amlavetas Ankol, Aparajita Apamarga

Aswagandha Aswakhurak, Atibala Bala

Dadima Devadaru Danti Durva

Guduchi Guggulu Haridra Haritaki

Indravaruni Jatamansi Jeevanti Jyotismati

Kapikachu Karanja Katak Katurohini

Katutumbi, Kesar Khadir Kusta

Ela Lodhra Madhuka, Mandukaparni

Marica Moorva Neel Kamal,

Patha Pippali Prisniparni Rasna

Rudraksha Sariba Satavari Sunti

Kantakari Trivrit Tulsi Vaca

Vasa Vibhitaki Yastimadhu Yavakshar

Ksheer Gorochan Madhu Navneet

Praval Lavak Mamsa of Black

Buck

Mayura

DRUGS HAVING VISHAGHNA PROPERTY (ANTIVIRAL)

National conference on AIDS and Ayurveda, 2000

Suvarnavasant Malati Rasa

Navjeevan Rasa

Aswagandha rasayan

Chyavanaprash Avaleha

Narasimha rasayan

Amritaprash

Brahmarasayan

Karpur Rasa

Gangadhar churna

Kutaj Ghan vati

Kutajarista

Mahajwarankush Rasa

Mahasudarsan churna

Amritarishta

Laghu Vasantmalati Rasa

Guduchi Satva

Panchagavaya Gritha

Kalyanaka Gritha

Tikta Gritha

Shringbhasma

Godanti bhasma

Abhrak bhasma

Vasavaleha

Vasa kwatha

Indukanta kwatha

Lavangadi vati

Kanchanar guggul

Arogyavardhini vati

Nimbadi choorna

Triphala choorna

Laxmivilas Rasa

Mahamrityunjay Rasa

Swaskasa Chintamani Rasa

Taleesadi choorna

Kantakari Avaleha

Sanjeevani vati

Swarna Vasanta Malati Rasa

Vardhaman pippali kalka

Laghuvasanta malati Rasa

Rudanti kalpa

Chyavanprasha

Amritaprash Ghritha

Shatpal Ghritha

Manjishtadi Kwath

Arogyavardhini Vati

Gandhak rasayana

Sarivadyasava

Khadirarishtha