Avamys fits the receptor pocket perfectly

Avamys fits the receptor pocket perfectly

Avamys has been designed to go into the alpha pocket of the glucocorticoid receptor

Avamys has been designed to go into the alpha pocket of the glucocorticoid receptor

Avamys unique structure has been designed to fully occupy the glucocorticoid receptor pocket as

completely as possible

Avamys unique structure has been designed to fully occupy the glucocorticoid receptor pocket as

completely as possible

1

1

1

Avamys is the first INS to show such a high binding with the

glucocorticoid receptor

Avamys is the first INS to show such a high binding with the

glucocorticoid receptor

All INS bind to the glucocorticoid receptor in the same way

and to the same degree

All INS bind to the glucocorticoid receptor in the same way

and to the same degree

Avamys shows effective binding with the

glucocorticoid receptor

Avamys shows effective binding with the

glucocorticoid receptor

No other INS will ever bind to the receptor better than Avamys

No other INS will ever bind to the receptor better than Avamys

Avamys is the first INS to show perfect binding with the glucocoticoid receptor

Avamys is the first INS to show perfect binding with the glucocoticoid receptor

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2

2

2

2

Avamys is more effective than any other INS because it binds

more strongly to the receptor and stays bound

Avamys is more effective than any other INS because it binds

more strongly to the receptor and stays bound

Avamys stays bound to the glucocorticoid receptor for longer

than other INS

Avamys stays bound to the glucocorticoid receptor for longer

than other INS

Avamys binds effectively to the receptor overtime.Avamys binds effectively to the receptor overtime.

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3

3

Avamys has a higher affinity for the receptor than Nasonex and

hence is more effective than Nasonex

Avamys has a higher affinity for the receptor than Nasonex and

hence is more effective than Nasonex

Avamys has a high affinity compared to other INS.

Avamys has a high affinity compared to other INS.

Avamys has the highest affinity compared

to other INS

Avamys has the highest affinity compared

to other INS

4

4

4

The enhanced affinity & extended tissue association of Avamys

means that it could be expected to lead to greater & more prolonged

anti-inflammatory effects compared to other INS

The enhanced affinity & extended tissue association of Avamys

means that it could be expected to lead to greater & more prolonged

anti-inflammatory effects compared to other INS

Whilst Avamys has enhanced affinity and extended tissue

association, it is impossible to speculate whether this might have any clinical implications.

Whilst Avamys has enhanced affinity and extended tissue

association, it is impossible to speculate whether this might have any clinical implications.

The enhanced affinity of Avamys is an unique pharmacological

property of Avamys.

The enhanced affinity of Avamys is an unique pharmacological

property of Avamys.

The enhanced affinity means that Avamys is the strongest

anti-inflammatory molecule compared to other INSs.

The enhanced affinity means that Avamys is the strongest

anti-inflammatory molecule compared to other INSs.

The unique pharmacokinetic properties of Avamys mean it is

the most effective INS currently available

The unique pharmacokinetic properties of Avamys mean it is

the most effective INS currently available

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5

5

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5

Avamys – leading the INS evolutionAvamys – leading the INS evolution

Statement 1 Statement 2 Statement 3

Statement 4 Statement 5