Autonomic Nervous Systemphipd16661/Chap_15_Autonomic_NS.pdf2) postsynaptic autonomic neuron cell...
Transcript of Autonomic Nervous Systemphipd16661/Chap_15_Autonomic_NS.pdf2) postsynaptic autonomic neuron cell...
Autonomic Nervous System
Chapter 15
• Anatomy of the
Autonomic Nervous
System
• Physiology of the
Autonomic Nervous
System
• Innervation and Control
of Autonomic Function
Nervous System
ANS
• Sensory (Afferent) Division brings visceral (thoracic and abdominal organs) and somatic (skeletal muscle, skin, bone and joints) sensory information into the CNS
• Motor (Efferent) Division sends out information from the CNS.
– somatic motor division innervates skeletal muscle
• Voluntary movement of skeletal muscles
– The Autonomic Nervous System is the visceral motor division of the PNS that innervates cardiac muscle, smooth muscle and glands
• sympathetic division (active, arousing responses)
• parasympathetic division (calming, maintenance functions like digestion)
Functional Divisions of PNS
Somatic vs Autonomic Pathways
Somatic Pathway uses only one motor neuron
Autonomic Pathway uses a series of two
neurons:
1) presynaptic autonomic neuron cell body is
in the CNS
2) postsynaptic autonomic neuron cell body
is in a ganglion
Somatic vs Autonomic Pathways
1 neuron
2 neurons
and a
ganglion
The ANS has Two Divisions
1. Sympathetic Division prepares body for physical activity.
– increases heart rate, BP, airflow, blood glucose levels and other functions
2. Parasympathetic Division has calming affect on many body functions and assists in maintenance and repair of tissues.
– increases digestion and waste elimination
• The two divisions may innervate the same target organ and may have contrasting effects.
• Effects of each depend upon which neurotransmitters are released.
Somatic Nervous System
Autonomic
Nervous
System
Para-
sympathetic
division
Sympathetic
division
Peripheral
nervous system
Effector
organs
Central
nervous system
Acetylcholine
Acetylcholine
Acetylcholine Norepinephrine
Ganglion
Ganglion
Adrenal medulla
Blood
vessel
Skeletal
muscle
Cardiac
muscle
Smooth
muscle
Glands
Epinephrine and
norepinephrine
Myelination Preganglionic
axons
(sympathetic)
Postganglionic
axons
(sympathetic)
Preganglionic
axons
(parasympathetic)
Postganglionic
axons
(parasympathetic)
• Somas of preganglionic sympathetic neurons
are in the lateral horn gray matter of the
thoracic to lumbar (thoracolumbar) spinal cord
regions T1-L2
• Somas of postganglionic sympathetic neurons
are in sympathetic ganglia that run along either
side of the vertebral column.
– chain ganglia
– collateral ganglia
Sympathetic Division of the ANS
Chain Ganglia and Collateral Ganglia
The Sympathetic Chain Ganglia
Adrenal Glands
• An Adrenal Gland sits above each kidney
• Adrenal Cortex secretes steroid hormones for chronic stress
• Adrenal Medulla is a modified sympathetic ganglion that secretes neurotransmitters (catecholamine hormones) into the blood in response to acute stress.
– catecholamines secreted by the adrenal medulla are:
epinephrine (85%) and norepinephrine (15%)
Parasympathetic Division
• Preganglionic Parasympathetic Neurons
originate from cranial and sacral levels of
the CNS.
• Long preganglionic axons synapse with
short postganglionic fibers in ganglia in
target organs.
Pathways of the Parasympathetic Division
Visceral Reflexes
• Unconscious responses to stimulation of cardiac
muscle, smooth muscle or glands.
• Receptors detect internal stimuli such as stretch,
chemicals, body temperature, etc.
• Afferent neurons carry signals to interneurons in
CNS.
• Efferent autonomic motor neurons carry motor
signals from the CNS to the effector organs (cardiac
muscle, smooth muscle and glands are the effector
organs)
• ANS modifies effector activity.
– example: response to high blood pressure
Example of a
Visceral
Reflex:
response to
High Blood
Pressure
• Stretch receptors in arteries, called Baroreceptors, sense high
blood pressure and send a signal to interneurons in the CNS.
• Autonomic motor neurons send efferent signals to the heart
that decreases heart rate and reduces blood pressure
Neurotransmitters and Receptors of the ANS
• Types of neurotransmitters released and types of receptors on target cells determines effects of ANS.
• Parasympathetic is predominantly cholinergic (receptors for acetylcholine).
• Sympathetic Division is cholinergic and adrenergic (receptors for norepinephrine).
• Many other substances are also released as neurotransmitters including:
– substance P, neuropeptide Y, nitric oxide
ANS Neurotransmitters and Receptors
Summary
Sympathetic Division
• preganglionic neurons are cholinergic (release ACh)
• postganglionic neurons have nicotinic cholinergic receptors
• postganglionic neurons are adrenergic (release norepinephrine)
• effector organs have a-adrenergic (stimulatory) or b-adrenergic (inhibitory) receptors
Parasympathetic Division
• preganglionic neurons are cholinergic (release ACh)
• postganglionic neurons have nicotinic cholinergic receptors
• postganglionic neurons are cholinergic (release ACh)
• effector organs have muscarinic cholinergic receptors
ANS
Neurotransmitters
and Receptors
Dual Innervation • Most of visceral organs receive nerve fibers from both
parasympathetic and sympathetic divisions
– antagonistic effects oppose each other:
• through dual innervation of same effector cells
– heart slowed down or speeded up
• through each division innervating different cells
– pupillary dilator muscle and pupillary constrictor
muscle change pupil size
– cooperative effects seen when 2 divisions act on different
effectors to produce a unified effect (salivation)
• parasympathetic NS increases salivary serous cell
secretion
• sympathetic NS increases salivary mucous cell secretion
Dual Innervation of the Iris
Control Without Dual Innervation
• Adrenal medulla, arrector pili muscles, sweat glands and
many blood vessels receive only sympathetic innervation.
• Sympathetic Tone results from neuron firing frequency:
• Increase Sympathetic firing frequency vasoconstriction
• Decrease Sympathetic firing frequency vasodilation
• Vasomotor tone can shift blood flow from one organ to
another according to changing needs
– sympathetic stimulation increases blood to skeletal and
cardiac muscles while reducing flow of blood to skin
Sympathetic Tone in Blood Vessels