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Australian and New ZealandIntensive Care Research Centre

Annual Report 2016

32

Director 3

About the ANZIC-RC 4

Governance 5

Staff 6

Students 7

Adjuncts 8

Visitors 9

Affiliates 9

Senior Research Fellows 10

Research Grants Active 11

NHMRC Funding Graphs 14

Awards 15

Publications 16

Publications Graph 20

Presentations 21

Table of Contents Director

It is with great pleasure that I introduce the 2016 annual report of the ANZIC Research Centre.

The Centre had 137 publications and major funding for exciting new collaborations. In 2016, the Centre was leading seven NHMRC-funded randomised controlled trials in intensive care medicine.

In 2016, NHMRC funding was approved for four grants to be led by the ANZIC-RC. There were three project grants: POLAR II (Prophylactic hypothermia in severe traumatic brain injury), TAME (Targeted therapeutic mild hypercapnia after resuscitated cardiac arrest), and TEAM (Treatment of invasively ventilated adults with early activity and mobilisation); and one translational grant, PREDICT (Early identification of disability to inform better care and outcomes in high risk patients). Also, our Deputy Directors were both awarded fellowships: Andrew Udy an NHMRC Early Career Fellowship, and Carol Hodgson a Future Leaders Fellowship by the Heart Foundation’s Research Program.

The NHMRC-funded TRANSFUSE (Standard issue transfusion versus fresher red blood cell use in intensive care) randomised controlled trial completed recruitment in December 2016. The trial recruited 5,000 patients across sites in Australia, New Zealand, Saudi Arabia, Finland and Ireland.

The Centre’s original articles in high impact journals for 2016 included one in the New England Journal of Medicine (Impact factor 60); two in JAMA (Impact factor 38); two in The Lancet Respiratory Medicine (Impact factor 15); and four in the American Journal of Respiratory and Critical Care Medicine (Impact factor 13).

I would like to thank our whole team of wonderful staff, adjuncts, students, affiliates and visiting researchers for their dedication to our Centre and its incredibly prolific research projects and programs.

Professor D. Jamie Cooper AODirector ANZIC-RC

54

The Australian and New Zealand Intensive Care Research Centre (ANZIC-RC) is the bi-national centre for the development, coordination and execution of pivotal multicentre randomised controlled trials (RCTs) in critically ill patients. The outcomes of its research have changed medical care in Australia and internationally, improved patient outcomes and lowered health care costs. The parallel role of the ANZIC-RC is a national teaching centre for doctoral, postdoctoral and international clinician researchers in critical care medicine.

It was established in February 2006, with funding from the National Health and Medical Research Council (NHMRC) and Monash University. It is located within the University’s Department of Epidemiology and Preventive Medicine, based in the Alfred Medical Research and Education Precinct (AMREP) in Melbourne.

The ANZIC-RC offers a range of services, from research advice to complete project management. Advice and assistance is available from experienced intensive care unit (ICU) researchers, data management/bio-statistical consultants, project managers, epidemiologists and health economists. The Centre coordinates

and conducts comprehensive research programs including observational studies; feasibility projects; and large multi-centred, interventional, randomised controlled trials. It has the ability to support small, medium and large clinical trials.The principal aims of the ANZIC-RC are to:• Conduct high impact, large-scale,

investigator-initiated clinical trials designed to determine best and most cost-effective practice in Intensive Care Medicine (ICM)

• Increase the quality of clinical trial design and biostatistical analysis in this field

• Be readily accessible to all Australian and New Zealand clinician-researchers in critical care

• Expand the national and international reach of large Australian and New Zealand led trials

• Introduce systems to integrate research results into clinical practice by promulgating research-based practice guidelines

• Develop integrated clinical research programs that provide the training ground for future clinical trialists in the field of ICM

• Encourage and support clinician researchers in research theory, study design, study conduct, data analysis and scientific writing.

About the ANZIC-RC ANZIC-RC Governance - Advisory Board

Prof Jamie

Cooper Director

ANZIC-RC

Prof Rinaldo Bellomo

Co-DirectorANZIC-RC and CICM

Representative

Prof John

McNeilHead

SPHPMMonash

Dr Marc

ZiegenfussPresident ANZICS

Mr Peter

GallagherCommunity

Representative

A/Prof Erica

WoodTransfusion

Research Unit SPHPM, MonashRepresentative

A/Prof Colin

McArthurNew Zealand

Representative

A/Prof Carol

Hodgson Co-Deputy

DirectorANZIC-RC

Prof Steve WebbInFACT

Representative

Prof David

PilcherChair

ANZICS-CORE

A/ProfCraig

FrenchChair

ANZICS-CTG

Dr Shay

McGuinnessNew Zealand

Representative

A/Prof Andrew

Udy Co-Deputy

DirectorANZIC-RC

76

ANZIC-RC Staff

Dr Zoe

McQuiltenSenior

ResearchFellow

Ms Lisa

HigginsResearch

Fellow

Ms Emma Ridley

Nutrition Research

Fellow

Dr MarkusSkrifvars

Senior Research

Fellow

Ms Emma

DonoghueCENTER-TBI

Research Fellow

MsBelinda Howe

Senior Project Manager:

SPICE Study

Ms Lorraine

LittleSenior Project

Manager: EPO-TBI and

TARGET Studies

Ms Vanessa

SinghResearch and

AdministrationOfficer

Ms Meredith

YoungProject

ManagerICU-Recovery

Study

Mr Tony

TrapaniProject

Manager POLAR Study

Ms Victoria BennettProject

Manager PHARLAP

Study

Ms Bridget

Ady Project

Manager TRANSFUSE

Study

Ms Veronica

PittProject

ManagerPATCHStudy

Ms Amanda Martin

Administration Manager

Prof Alistair Nichol

Intensivist

Prof Michael Bailey

Statistician

Ms Lynne

MurrayResearch and

Blood-CRE Manager

Prof DJ (Jamie)

Cooper Director

Prof Rinaldo Bellomo

Co-Director

A/Prof Carol

Hodgson Co-Deputy

Director

Prof Steve Webb

Intensivist

A/Prof DarylJones

Intensivist

Ms Rachael

KableResearch and

AdministrationOfficer

Mr Chun Kwan

Research and Administration

Officer

Ms Maya

GeorgeProject

ManagerSPRINT-SARI

Study

Ms Genevieve

O’NeillProject

ManagerREMAP-CAP

Study

ANZIC-RC Students

Dr Helen

AcklandPhD

Conferred 2012

Dr Antoine

SchneiderPhD

Conferred 2015

A/Prof Daryl JonesPhD

Conferred 2015

DrRalph

TrammPhD

Conferred 2016

Dr MattBrainPhD

Scholar

DrDashiellGantner

PhD Scholar

Dr Neil

GlassfordPhD

Scholar

Dr Elizabeth

MoorePhD

Conferred 2014

Ms Bianca

LevkovichPhD

Scholar

Dr Neil

OrfordPhD

Scholar

Ms EmmaRidleyPhD

Scholar

MsClaire

TippingPhD

Scholar

DrNor’azim

Mohd YunosPhD

Scholar

Mr Simon Landes

BMedSc (Hons)Completed 2012

Mr EdwardQuine


Ms Lisa

HigginsPhD

Scholar

Mr Eldho PaulPhD

Scholar

Ms MadelineCenedese

BHlthSc (Hons)Completed 2015

Mr ZacharyO’Brien


DrRafidah

AtanPhD

Scholar

DrRavi

TiruvoipatiPhD

Scholar

Dr AidanBurrell

PhD Scholar

Dr Tim

CoulsonPhD

Scholar

Ms Michelle

PatonPhD

Scholar

98

ANZIC-RC Adjuncts

ProfCécile

Aubron

Prof Tracey

Bucknall

Prof Gilles

Capellier

A/ProfMarianneChapman

A/ProfAndrewDavies

Dr Peter

Kruger

A/ProfColin

McArthur

Dr Shay

McGuinness

A/ProfCristina

Morganti-Kossmann

ProfJohn

Myburgh

MsLynetteNewby

MsRachael

Parke

A/ProfSandraPeake

ProfVille

Pettilä

Prof David

Pilcher

A/Prof Jeff

Presneill

A/Prof YaseenArabi

A/Prof Glenn

Eastwood

Dr Andrew

Flint

Dr Samir

Haddad

MsSue

Huckson

ProfOlivierHuet

ProfJacques

Duranteau

Dr AnthonyDelaney

ProfMichaelReade

MsElissa

Robins

DrMatthieuSchmidt

DrIan

Seppelt

Mr Mick

Stephenson

Ms Shirley

Vallance

MsLeonie

Weisbrodt

MsTricia

Williams

MsJudyWills

A/Prof Andrew

Udy

DrGuillaume Carteaux(France)2010-1

ProfGilles

Capellier(France)2011-2

Dr Matthieu Schmidt (France)2013-4

Dr Aude

Garnero(France)2013-4

ProfKathy

Rowan(UK)

2013 and 2015

A/Prof Theodore (Jack)

Iwashyna(USA)2015

Prof Rob

Sladen(USA)

2015 and 2016

ANZIC-RC Affiliates

MsShaila

Chavan

A/Prof Maija

Kaukonen

MsKerry

McClean

Dr Tài

Pham

ProfKathy

Rowan

MsJane

Parker

DrVirginia

Newcombe

DrHeatherWaddy

Ms Allison

van Lint

Dr Ralph

Tramm

Dr Kapil Dev

Soni

ANZIC-RC Visitors

DrAude

Garnero

1110

ANZIC-RC Senior Research Fellows

A/Prof DarylJones

(Australia)2006

Prof AlistairNichol

(Ireland)2007

DrAndrew

Westbrook(Ireland)

2008

Prof Cécile

Aubron(France)

2010

A/ProfCarol

Hodgson(Australia)

2011

ProfVille

Pettilä(Finland)

2009

A/Prof Maija

Kaukonen(Finland)2012-3

DrDashiellGantner

(Australia)2012

A/ProfAndrewDavies

(Australia)2014-5

Research Grants Active in 2016Title Agency /

Grant TypeChief Investigator/s Year/s of

FundingTotal

AmountAdministering Institution

Improving outcomes in patients with community-acquired severe sepsis: The role of pre-hospital antibiotics

NHMRC #1124532Early Career Fellowship

Udy A 2017-2020 $265,138 Monash (ANZIC-RC)

POLAR II (continuation for RCT of prophylactic hypothermia in severe traumatic brain injury)

NHMRC #1121037Project Grant

Cooper DJ, Nichol A, Rosenfeld J, Presneill J, Cameron P

2017-2018 $266,321 Monash (ANZIC-RC)

PREDICT: Early Identification of Disability to Inform Better Care and Outcomes in High Risk Patients

NHMRC #1132976Translational Project Grant

Hodgson C, Cooper DJ, Myles P, T..., Bailey M, Shulman M, Bellomo R, McNeil J, Higgins A

2017 $97,000 Monash (ANZIC-RC)

STARRT-AKI: STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury

NHMRC #1127121 Project Grant

Gallagher M, Bagshaw S, Endre Z, Gattas D, Udy A

2017-2021 $2,112,447 The George Institute

TAME: Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest


Bernard S, Eastwood G, Bellomo R, Stub D, Archer J, Hodgson C

2017-2021 $2,069,878 Monash (ANZIC-RC)

TEAM: Treatment of invasively ventilated adults with Early Activity and Mobilisation Study


Hodgson C, Gabbe B, Webb S, Presneill J, Young P, Iwashyna T

2017-2021 $1,467,137 Monash (ANZIC-RC)

Intensive nutrition in critically ill adults: A pilot randomised controlled study (US$1,852,684)

Baxter Healthcare Corporation

Ridley E, Chapple L-A, Davies A, Deane A, McGuinness S, Hodgson C, Parke R, Cooper DJ, Bailey M

2017-2021 $2,400,00 Monash (ANZIC-RC)

TAME: Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest: A Phase III Multi-Centre Randomised Controlled Trial (€ 999,995)

Health Research Board, Ireland DIFA-2017-036Project Grant

Nichol AD, et al 2017-2020 $1,377,281 University College, Dublin

ICU-ROX: A multi-centre, randomised, single blinded clinical trial comparing conservative oxygen therapy to standard care in mechanically ventilated adults in the Intensive Care Unit (NZ$1,404,525)

Health Research Council of NZ

Young P, Bellomo R, et al 2017-2020 $1,404,525 MRINZ

PLUS: PLasmalyte versUs Saline for intravenous fluid therapy in ICU(NZ$1,385,525)


Young P, Bellomo R, et al 2017-2020 $1,289,756 MRINZ

Pre-hospital anti-fibrinolytics for traumatic coagulopathy and haemorrhage (NZ$943,384)


McArthur C, et al 2017-2019 $878,176 MRINZ

TRiCS III: Transfusion requirements in patients for cardiac surgery (NZ$1,199,468)


McGuinness S, et al 2017-2019 $1,116,666 MRINZ

Future Leaders Fellowship: Recovery after critical illness from cardiovascular failure

Heart Foundation Research Fellowship

Hodgson C 2017-2020 $520,000 Monash (ANZIC-RC)

PROMOTE-SAH: PROspective Multicentre Observational sTudy of anEurysmal SubArachnoid Haemorrhage in Australasian intensive care

Intensive Care Foundation (ICF)Project Grant

Udy A, Cooper DJ, Cohen J, Bellomo R, Vladic C


SOFTER: Effect of denosumab on bone turnover markers in critically ill women

ICF Project Grant

Orford NR, Cooper J, Bellomo R, Bailey M, Kotowicz M, et al


ECMO-PT: Physical training for patients reciving extracorporeal membrane oxygenation to improve recovery

Monash, FMNHS Strategic Grant SGS17-0602

Hodgson C, Cooper DJ, Bailey M, Pellegrino V, Fan E, McGiffin D


PROMOTE-SAH: PROspective Multicentre Observational sTudy of anEurysmal SubArachnoid Haemorrhage in Australasian intensive care

Monash, FMNHS Strategic GrantSGS17-0639

Cooper DJ, Udy A, Hodgson C, Delaney A, Cohen J


APPRISE: Australian Partnership (for) Preparedness Research on InfectiouS (disease) Emergencies

NHMRC #1116530Centre for Research Excellence

Lewin S, Sorrell T, McVernon J, Webb S, Kaldor J, Andrews R, Cheng A, Gilbert L, et al

2016-2020 $4,996,416 University of Melbourne

Optimising transfusion support in critical illness and haemotological malignancies

NHMRC #1111485Early Career Fellowship

McQuilten Z 2016-2019 $262,251 Monash (ANZIC-RC)

Dr MarkusSkrifvars(Finland)2016-7

1312

Research Grants Active in 2016 (continued) Research Grants Active in 2016 (continued)

Title Agency / Grant Type

Chief Investigator/s Year/s of Funding

Total Amount

Administering Institution

A research program testing feasibility and impact of early of fibrinogen concentrate therapy in adults with traumatic haemorrhage

Alfred Foundation (Borrowman Trust)Project Grant

Cooper DJ 2015-2016 $24,850 Alfred

IS-HR-BAD: Ivabradine in sepsis for heart rate, benefits and disadvantages trial; an open-label phase II feasibility study

Alfred Research Trusts #T11512Project Grant

Rozen T, Udy A 2015-2016 $8,922 Alfred

Centre for Research in Intensive Care (DKK 36,000,000)

Danish Strategic Research Council

Perner A, ..., Myburgh JA, Pettilӓ V, Egerød I, ... , Rowan K, et al

2015-2020 $7,400,000 Copenhagen University

Investigating the role of lysophosphatidic acid (LPA) in pediatric brain injury

NIH (R03)Project Grant

Lifshitz J, Morganti-Kossmann MC, et al

2015-2017 $110,000 University of Arizona

Frailty in ICU trauma patients: a prospective observational study

Royal Perth Medical Research FoundationProject Grant

Tipping C 2015-2018 $18,000 Royal Perth

OzENTER-TBI: Australian-European NeuroTrauma Effectiveness Research, Traumatic Brain Injury Collaboration

TAC/ISCRRProject GrantN-14-129

Cooper DJ 2015-2018 $118,271 Monash(ANZIC-RC)

OzENTER-TBI Australia-Europe NeuroTrauma Effectiveness Research in Traumatic Brain Injury collaboration

NHMRC #1074181EU Collaborative Research Grant

Cooper DJ, Gruen R 2014-2016 $358,348 Monash(ANZIC-RC)

PREPARE: Platform for European Preparedness Against Re-emerging Epidemics-Australia

NHMRC #1074888EU Collaborative Research Grant

Webb SAR, et al 2014-2016 $375,834 University of WA

MTR: Improving outcomes for patients with critical bleeding requiring massive transfusion

NHMRC #1074654Partnership Project

Cooper DJ, Wood E, Cameron P, Isbister J, French C, Stanworth S, ..., McQuilten Z, et al

2014-2016 $861,706 Monash(ANZIC-RC)

Investigating the effects of the age of transfused red cells on haemolysis and iron metabolism in critically ill patients: a TRANSFUSE sub study

ARCBSCollaborative funding

McQuilten Z, Aubron C, Pasricha S-R, Sparrow R, Wood E, Flower R, Irving D

2014-2016 $72,000 Monash

TRANSFUSE-RCT: Standard issue transfusion versus fresher red blood cell use in intensive care

ARCBSCollaborative funding

Cooper DJ, McQuilten Z, Murray L

2014-2017 $300,000 Monash (ANZIC-RC)

Diggers to Veterans: risk, resilience and recovery in the First AIF

ARCDiscovery Project

McCalman J, Kippen R, Reade MC, Shanks D, Hopper D

2014-2017 $560,000 University of Melbourne

Improving outcomes in critical illness (€2,350,000)

Health Research Board, IrelandProject Grant

Nichol A, Cooper DJ, Laffey J, McLoughlin P, Ryan T, McAuley D

2014-2019 $3,421,450 University College, Dublin

PHARLAP: Permissive Hypercapnia and Alveolar Recruitment with Limited Airway Pressures (€89,000)


Nichol A, et al 2014-2016 $129,570 University College, Dublin

TRANFUSE IRELAND: ‘STandaRd Issue TrANsfusion versuS Fresher red blood cell Use in intenSive carE (€799,999)


Nichol A, Cooper DJ, Laffey J, McLoughlin P, Ryan T, McAuley D

2014-2019 $1,154,161 University College, Dublin

RELIEF: Restrictive vs liberal fluid therapy in major abdominal surgery (NZ$770,668)

Health Research Council of NZProject Grant

McGuinness S, et al 2014-2017 $757,846 Auckland District Health Board

SPICE III: Early goal directed sedation in mechanically ventilated intensive care patients (NZ$1,118,620)


McArthur C, Bellomo R, Henderson S, McGuinness S, Young P, Williams A, et al

2014-2018 $1,061,170 Auckland District Health Board

Blood-CRE: CRE for Patient Blood Management in Critical Illness and Trauma

NHMRC #1040971Centre of Research Excellence

Cooper DJ, Phillips L, Bellomo R, Cameron P, Reade M, Isbister J, French C, Myles P, Webb S, McNeill J

2012-2017 $2,498,407 Monash (ANZIC-RC)

NHMRC Postgraduate Scholarship NHMRC #1075288PostgraduateScholarship

Ridley E 2014-2016 $102,578 Monash(ANZIC-RC)

Title Agency / Grant Type

Chief Investigator/s Year/s of Funding

Total Amount Administering Institution

ITACS: IV iron for Treatment of Anaemia before Cardiac Surgery


Myles P, Richards T, Smith J, Cooper DJ, Wood E, et al

2016-2020 $2,285,290 Monash

OPTIMISE-CAP: Optimisation by Platform Trial Involving Multiple Interventions with Simultaneous Evaluation in Community Acquired Pneumonia


Webb S, McArthur C, Berry D, Paterson D, Cheng A, Heritier S, Presneill J, Litton E

2016-2020 $4,413,145 Monash (ANZIC-RC)

PLUS: Plasma-Lyte 148® versUs Saline (PLUS) study


Finfer S, Myburgh J, Bellomo R, Young P, Gattas D, et al

2016-2019 $5,984,819 University of Sydney

Creation of automatic alerts to identify patients at risk of deterioration after discharge from ICU

Alfred Health Top 100 Innovation Grant

Ihle J, Scheinkestel C, Pilcher D, Larkins A, Mwagiru A, Schneider H, Bucknall T, Ng Y, Gilbert A

2016 $100,000 Alfred

Empirical beta-lactam therapy in the Alfred ICU: does current dosing achieve sufficient drug exposure in high risk critically-ill adults?

Alfred Research TrustsProject Grant

Padiglione A, Udy A 2016 $9,840 Alfred

PIPICU: Pressure injury prediction in the ICU - A predictive model

Alfred Research TrustsProject Grant

Mason C, Pilcher D 2016 $10,000 Alfred

Travel Grant: ATS, UCSF - USA CASS FoundationTravel Grant

Hodgson C 2016 $3,750 Monash(ANZIC-RC)

ROCIT: Restoration Of the microbiome in CrITical Illness

Government of WA, Department of Health Translational Project Grant

Litton E, Wood F, Raby E, Manning L, Strunk T, Paparini A, Gummer J, Trengove R, Currie A, Higgins A, Rammohan A, et al

2016-2018 $269,307 Fiona Stanley

Hearts of ECMO Registry Australia-Canada (US$15,000)

Hearts of ECMOProject Grant

Hodgson C, Fan E 2016 $20,770 Monash(ANZIC-RC)

FITBITS: Next generation assessments of physical function in ICU survivors

ICFProject Grant

Skinner E, Iwashyna TJ, Higgins A, Hodgson C

2016 $35,000 Monash(ANZIC-RC)

IH-TALI: Induced Hypernatremia - a therapy for acute lung injury?

ICFProject Grant

Bersten A, Bihari S, van Haren F, Prakesh S, Cooper DJ, Dixon DL

2016 $32,780 Flinders Medical

Senior Post Doctoral Fellowship Monash, FMNHS Fellowship

Hodgson C 2016 $35,000 Monash(ANZIC-RC)

A pilot randomised placebo-controlled trial evaluating the feasibility and effects of early administration of fibrinogen concentrate in adults with traumatic haemorrhage

Monash Strategic Grant

McQuilten Z, Wood E, Mitra B 2016 $49,336 Monash(ANZIC-RC)

NHMRC Practitioner Fellowship Level II NHMRC #1081884Practitioner Fellowship

Myburgh JA 2015-2019 $551,435 University of Sydney

ADRENAL-GEPS: Gene expression profiling in critically ill patients with septic shock


Evans D, Venkatesh B, Powell J, Myburgh JA, Finfer S, Cohen J

2015-2019 $834,269 University of Queensland

ASPREE-NEURO: Aspirin and cerebral microhaemorrhages


McNeil J, Egan G, Brodtmann A, Ward S, Ferris N, Bailey M

2015-2017 $956,186 Monash

SUDDICU: Cluster RCT of selective decontamination of the digestive tract in critically ill ventilated patients


Seppelt I, Myburgh JA, Finfer S, Iredell J, Davis J, Marshall A, Taylor C, Cuthbertson B

2015-2019 $3,960,000 University of Sydney

TARGET: The Augmented versus Routine approach to Giving Energy Trial


Chapman M, Peake S, Bellomo R, Horowitz M, Davies A, Deane A

2015-2019 $3,534,236 Monash (ANZIC-RC)

TREATT: Trial to evaluate anti-fibrinolytic therapy in thrombocytopenia


Wood E, Stanworth S, Cole-Sinclair M, Westerman D, Szer J, Estcourt L, McQuilten Z

2015-2019 $1,012,635 Monash

ICU Recovery: Critical illness and long-term recovery - motomed cycle ergometer with muscle stimulation

Alfred FoundationProject Grant

Hodgson C 2015-2016 $25,000 Monash(ANZIC-RC)

1514

Research Grants Active in 2016 (continued) Title Agency /

Grant TypeChief Investigator/s Year/s of

FundingTotal Amount Administering

InstitutionNHMRC Practitioner Fellowship Level II NHMRC #1044787

Practitioner Fellowship

Bellomo R 2013-2017 $228,270 Austin

NHMRC Practitioner Fellowship Level II NHMRC #1041922Practitioner Fellowship

Cooper DJ 2013-2017 $380,450 Monash (ANZIC-RC)

ANTISEPSIS: AspiriN To Inhibit SEPSIS trial NHMRC #1041986 Project Grant

Eisen D, Leder K, McBryde E, Wolfe R, Pilcher D, et al

2013-2016 $391,879 Monash

RELIEF: Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery


Myles P, Bellomo R, ChristophiC, Corcoran T, Forbes A, et al

2013-2016 $2,384,173 Monash

PATCH: Pre-hospital Antifibrinolytics for Traumatic Coagulopathy and Haemorrhage


Bernard S, Mitra B, Gruen R, Gantner D, Medcalf R, Reade M, Tran H

2013-2016 $1,668,152 Monash

SMARTT: Sampling antibiotics in renal replacement therapy


Roberts J, Lipman J, Roberts M, Paul S, Peake S, Turnidge J

2013-2016 $1,034,979 University ofQueensland

SPICE Sedation Practices in IntensiveCare Evaluation - RandomisedControlled Trial (RCT)


Shehabi Y, Bellomo R, Reade M,Seppelt I, McArthur C, Bailey M,Howe B

2013-2017 $2,752,725 Monash(ANZIC-RC)

Understanding tissue responses to fluid resuscitation and blood transfusion during ovine sepsis to improve outcomes


Fraser J, Maitland K, Shekar K, Reade MC, Chew M, Fung YL, Tung J

2013-2016 $1,000,000 Prince Charles Hospital Foundation

Supplemental Parenteral Nutrition in Critically Ill Patients: Pilot Randomised Controlled Study

Baxter Healthcare CorporationProject Grant

Davies A, Cooper DJ 2013-2016 $321,691 Monash (ANZIC-RC)

CENTER-TBI: Collaborative European NeuroTrauma Effectiveness Research in TBI (Total Grant €30m, Australian component €279,499)

European Union’s Seventh Framework Programme for Research (EU FP7)

Maas A, Menon D, Hill S, Steyerberg E, von Steinbüchel N, Brazinova A, Buki A, Tenovuo O, Van Hecke W, ... Cooper DJ, et al

2013-2020 $409,491 Monash(ANZIC-RC)

ADRENAL: Randomised trial of hydrocor-tisone in critically ill patients with septic shock (NZ$773,854)


McArthur C, Venkatesh B, Young P, McGuinness S, ..., Myburgh J, Henderson S

2012-2016 $732,900 Auckland District Health Board

Early Interventions to improve outcomes after traumatic brain injury

TAC / VNI #D162Project Grant

Cooper DJ, Cameron P, Bernard S, Rosenfeld J, Nichol A

2010-2017 $2,086,100 Monash(ANZIC-RC)

Total $68,843,001

NHMRC Funding Graphs (ANZIC-RC Administered Grants)

Awards

Congratulations to the ANZIC-RC staff, students and adjuncts who received awards in 2016, as follows:

• Rinaldo Bellomo: Named on the 2016 Thomson Reuters list of Highly Cited (HiCi) Researchers, placing them among the top one per cent of the most highly cited researchers in the world within their subject area

• Andrew Udy: NHMRC Early Career Fellowship. 2017-2020

• Carol Hodgson: Heart Foundation Research Program Future Leaders Fellowship. 2017-2020

• Andrew Udy (Adjunct A/Professor): Alfred Health Senior Medical Staff Prize for Clinical Research for “The Association Between Low Admission Peak Plasma Creatinine Concentration and In-Hospital Mortality in Patients Admitted to Intensive Care in Australia and New Zealand” co-contributors included Pilcher D, Bailey M, and the Australian and New Zealand Intensive Care Society Centre for Outcomes and Resource Evaluation

• Platinum Level ELSO Award for Excellence in Life Support - The Alfred (V Pellegrino, DJ Cooper)

• All AMREP 2016 Research Prize: Cooper DJ for Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R. Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis. N Engl J Med 2015

• AMREP Clinical Research Mid-Career Researcher Best Paper. Schmidt M, Stewart C, Bailey M, Nieszkowska A, Kelly J, Murphy L, Pilcher D, Cooper DJ, Scheinkestel C, Pellegrino V, Forrest P, Combes A, Hodgson C. Mechanical ventilation management during extracorporeal membrane oxygenation for acute respiratory distress syndrome: a retrospective international multicenter study. Crit Care Med 2015

• Alfred Research Week: Senior Medical Staff Prize for Clinical / Public Health Research for poster, Disability And Poor Return To Work After Critical Illness: A Multicentre Cohort Study. Hodgson C, Bellomo R, Gabbe B, Barrett J, Hunt-Smith J, Higgins A, Iwashyna J, Myles P, Ponsford J, Pilcher D, Kulkarni J, Murray L, Bucknall T, Udy A, Walker C, Young M, Cooper DJ

• The inaugural Henry Krum Monash Early Career Researcher Publication Prize for Clinical Sciences. Hodgson C, et al. Early mobilization and recovery in mechanically ventilated patients in the ICU: a bi-national, multi-centre, prospective cohort study. Crit Care 2015

• Ralph Tramm: PhD conferred, “Short and longer term health related outcomes in patients receiving extracorporeal membrane oxygenation (ECMO)”, Supervisors Dragan Ilic and Carol Hodgson

• ACTA Trial of the Year Finalist: The NHMRC and TAC funded EPO-TBI trial (CI-A Bellomo R), coordinated by the ANZIC-RC and Project Managed by Lorraine Little, was a finalist in the inaugural Australian Clinical Trials Alliance (ACTA) Trial of the Year Award. The award was for an investigator-driven trial for which the primary results were published in 2015, that addressed a critical gap in the evidence, was of an exceptional standard in terms of scientific rigour, and were expected to translate to a significant change in policy or practice. Craig French accepted the award on behalf of the EPO-TBI Management Committee.

Rinaldo Bellomo

1716

Journal Publications 1. Ackland HM, Pilcher DV, Roodenburg OS, McLellan SA,

Cameron PA, Cooper DJ. Danger at every rung: Epidemiology and outcomes of ICU-admitted ladder-related trauma. Injury 2016;47:1109-17.

2. Alwis DS, Yan EB, Johnstone V, Carron S, Hellewell S, Morganti-Kossmann MC, Rajan R. Environmental Enrichment Attenuates Traumatic Brain Injury: Induced Neuronal Hyperexcitability in Supragranular Layers of Sensory Cortex. J Neurotrauma 2016;33:1084-101.

3. Atan R, Peck L, Visvanathan K, Skinner N, Eastwood G, Bellomo R, Storr M, Goehl H. High cut-off hemofiltration versus standard hemofiltration: effect on plasma cytokines. Int J Artif Organs 2016;39:479-86.

4. Aubron C, DePuydt J, Belon F, Bailey M, Schmidt M, Sheldrake J, Murphy D, Scheinkestel C, Cooper DJ, Capellier G, Pellegrino V, Pilcher D, McQuilten Z. Predictive factors of bleeding events in adults undergoing extracorporeal membrane oxygenation. Ann Intensive Care 2016;6:97.

5. Bartz RR, Gantner D, Gordon AC, Leligdowicz A, McNamee JJ, Murthy S, Nichol A, Webb S. Who Says There Is No “I” in Team? Achieving Individual Success in Collaborative Clinical Research in Critical Care. Am J Respir Crit Care Med 2016;194:911-2.

6. Beck B, Bray JE, Cameron PA, Cooper DJ, Gabbe BJ. Trends in severe traumatic brain injury in Victoria, 2006-2014. Med J Aust 2016;204:407.

7. Bellomo R, Hodgson CL. Improving the care of critically ill and postoperative patients with acute kidney injury. Anaesth Crit Care Pain Med 2016;35:79-80.

8. Bellomo R, Martensson J, Kaukonen KM, Lo S, Gallagher M, Cass A, Myburgh J, Finfer S. Epidemiology of RBC Transfusions in Patients With Severe Acute Kidney Injury: Analysis From the Randomized Evaluation of Normal Versus Augmented Level Study. Crit Care Med 2016;44:892-900.

9. Bellomo R, Martensson J, Lo S, Kaukonen KM, Cass A, Gallagher M. Femoral Access and Delivery of Continuous Renal Replacement Therapy Dose. Blood Purif 2016;41:11-7.

10. Bellomo R, Martin A, Cooper DJ. The Australian and New Zealand Intensive Care Research Centre. Blood Purif 2016;41:I-IV.

11. Bergin K, Moore E, McQuilten Z, Wood E, Augustson B, Blacklock H, Ho J, Horvath N, King T, McNeil J, Mollee P, Quach H, Reid CM, Rosengarten B, Walker P, Spencer A. Design and development of the Australian and New Zealand (ANZ) myeloma and related diseases registry. BMC Med Res Methodol 2016;16:151.

12. Bihari S, Bailey M, Bersten AD. Steroids in ARDS: to be or not to be. Intensive Care Med 2016;42:931-3.

13. Bihari S, Teubner DJ, Prakash S, Beatty T, Morphett M, Bellomo R, Bersten A. Fluid bolus therapy in emergency department patients: Indications and physiological changes. Emerg Med Australas 2016;28:531-7.

14. Blombery P, Kivivali L, Pepperell D, McQuilten Z, Engelbrecht S, Polizzotto MN, Phillips LE, Wood E, Cohney S. Diagnosis and management of thrombotic thrombocytopenic purpura (TTP) in Australia: findings from the first 5 years of the Australian TTP/thrombotic microangiopathy registry. Intern Med J 2016;46:71-9.

15. Botha J, O’Brien Y, Malouf S, Cole E, Ansari ES, Green C, Tiruvoipati R. The Outcome and Predictors of Mortality in Patients Therapeutically Cooled Postcardiac Arrest. J Intensive Care Med 2016;31:603-10.

16. Bragge P, Synnot A, Maas AI, Menon DK, Cooper DJ, Rosenfeld JV, Gruen RL. A State-of-the-Science Overview of Randomized Controlled Trials Evaluating Acute Management of Moderate-to-Severe Traumatic Brain Injury. J Neurotrauma 2016;33:1461-78.

17. Brazinova A, Rehorcikova V, Taylor MS, Buckova V, Majdan M, Psota M, Peeters W, Feigin V, Theadom A, Holkovic L, Synnot A. Epidemiology of Traumatic Brain Injury in Europe: A Living Systematic Review. J Neurotrauma 2016;epub.

18. Byhoff E, Harris JA, Langa KM, Iwashyna TJ. Racial and Ethnic Differences in End-of-Life Medicare Expenditures. J Am Geriatr Soc 2016;64:1789-97.

19. Cabrini L, Landoni G, Antonelli M, Bellomo R, Colombo S, Negro A, Pelosi P, Zangrillo A. Critical care in the near future: patient-centered, beyond space and time boundaries. Minerva Anestesiol 2016;82:599-604.

20. Cade JF, Jones DA, Bellomo R. Nutrition in the intensive care unit - you must breathe what you eat. Crit Care Resusc 2016;18:224-7.

21. Chalwin R, Radford S, Psirides A, Laver R, Bierer P, Rai S, Knott C, Dyett J, Jones D. Participant perceptions of a rapid response team training course. Crit Care Resusc 2016;18:283-8.

22. Chan P, Peake S, Bellomo R, Jones D. Improving the Recognition of, and Response to In-Hospital Sepsis. Curr Infect Dis Rep 2016;18:20.

23. Chiam E, Weinberg L, Bailey M, McNicol L, Bellomo R. The haemodynamic effects of intravenous paracetamol (acetaminophen) in healthy volunteers: a double-blind, randomized, triple crossover trial. Br J Clin Pharmacol 2016;81:605-12.

24. Cnossen MC, Scholten AC, Lingsma HF, Synnot A, Tavender E, Gantner D, Lecky F, Steyerberg EW, Polinder S. Adherence to Guidelines in Adult Patients with Traumatic Brain Injury: A Living Systematic Review. J Neurotrauma 2016;epub.

25. Cooper DJ, Nichol A, Hodgson C. Craniectomy for Traumatic Intracranial Hypertension. N Engl J Med 2016;375:2402.

26. Cooper DJ, Nichol A, Presneill J. Hypothermia for Intracranial Hypertension after Traumatic Brain Injury. N Engl J Med 2016;374:1384.

27. Coulson TG, Bailey M, Reid CM, Tran L, Mullany DV, Parker J, Hicks P, Pilcher D. Acute risk change (ARC) identifies outlier institutions in perioperative cardiac surgical care when the standardized mortality ratio cannot. Br J Anaesth 2016;117:164-71.

28. Crighton GL, Scarborough R, McQuilten ZK, Phillips LE, Savoia HF, Williams B, Holdsworth R, Henry A, Wood EM, Cole SA. Contemporary management of neonatal alloimmune thrombocytopenia: good outcomes in the intravenous immunoglobulin era: results from the Australian neonatal alloimmune thrombocytopenia registry. J Matern Fetal Neonatal Med 2016;epub.

29. Di Muzio F, Presello B, Glassford NJ, Tsuji IY, Eastwood GM, Deane AM, Ekinci EI, Bellomo R, Martensson J. Liberal Versus Conventional Glucose Targets in Critically Ill Diabetic Patients: An Exploratory Safety Cohort Assessment. Crit Care Med 2016;44:1683-91.

30. Eastwood GM, Schneider AG, Suzuki S, Peck L, Young H, Tanaka A, Martensson J, Warrillow S, McGuinness S, Parke R, Gilder E, McCarthy L, Galt P, Taori G, Eliott S, Lamac T, Bailey M, Harley N, Barge D, Hodgson CL, Morganti-Kossmann MC, Pebay A, Conquest A, Archer JS, Bernard S, Stub D, Hart GK, Bellomo R. Targeted therapeutic mild hypercapnia after cardiac arrest: A phase II multi-centre randomised controlled trial (the CCC trial). Resuscitation 2016;104:83-90.

31. Eastwood GM, Tanaka A, Bellomo R. Cerebral oxygenation in mechanically ventilated early cardiac arrest survivors: The impact of hypercapnia. Resuscitation 2016;102:11-6.

32. Eastwood GM, Tanaka A, Espinoza ED, Peck L, Young H, Martensson J, Zhang L, Glassford NJ, Hsiao YF, Suzuki S, Bellomo R. Conservative oxygen therapy in mechanically ventilated patients following cardiac arrest: A retrospective nested cohort study. Resuscitation 2016;101:108-14.

Publications Publications (continued)

Journal Publications (continued)33. Efendijev I, Raj R, Skrifvars MB, Hoppu S, Reinikainen M.

Increased need for interventions predicts mortality in the critically ill. Acta Anaesthesiol Scand 2016;60:1415-24.

34. Egi M, Krinsley JS, Maurer P, Amin DN, Kanazawa T, Ghandi S, Morita K, Bailey M, Bellomo R. Pre-morbid glycemic control modifies the interaction between acute hypoglycemia and mortality. Intensive Care Med 2016;42:562-71.

35. Fan E, Gattinoni L, Combes A, Schmidt M, Peek G, Brodie D, Muller T, Morelli A, Ranieri VM, Pesenti A, Brochard L, Hodgson C, Van Kiersbilck C, Roch A, Quintel M, Papazian L. Venovenous extracorporeal membrane oxygenation for acute respiratory failure : A clinical review from an international group of experts. Intensive Care Med 2016;42:712-24.

36. Fealy N, Osborne C, Eastwood GM, Glassford N, Hart G, Bellomo R. Nasal high-flow oxygen therapy in ICU: A before-and-after study. Aust Crit Care 2016;29:17-22.

37. Fennessy G, Hilton A, Radford S, Bellomo R, Jones D. The epidemiology of in-hospital cardiac arrests in Australia and New Zealand. Intern Med J 2016;46:1172-81.

38. Gabriel LE, Bailey MJ, Bellomo R, Stow P, Orford N, McGain F, Santamaria J, Scheinkestel C, Pilcher DV. Insurance status and mortality in critically ill patients. Crit Care Resusc 2016;18:43-9.

39. Garnero A, Hodgson C, Arnal JM. Transpulmonary pressure cannot be determined without esophageal pressure in ARDS patients. Minerva Anestesiol 2016;82:121-2.

40. Glassford NJ, French CJ, Bailey M, Martensson J, Eastwood GM, Bellomo R. Changes in intravenous fluid use patterns in Australia and New Zealand: evidence of research translating into practice. Crit Care Resusc 2016;18:88.

41. Glassford NJ, Martensson J, Eastwood GM, Jones SL, Tanaka A, Wilkman E, Bailey M, Bellomo R. Defining the characteristics and expectations of fluid bolus therapy: A worldwide perspective. J Crit Care 2016;35:126-32.

42. Hay A, Bellomo R, Pilcher D, Jackson G, Kaukonen KM, Bailey M. Characteristics and outcome of patients with the ICU Admission diagnosis of status epilepticus in Australia and New Zealand. J Crit Care 2016;34:146-53.

43. Hayes K, Holland AE, Pellegrino VA, Leet AS, Fuller LM, Hodgson CL. Physical function after extracorporeal membrane oxygenation in patients pre or post heart transplantation - An observational study. Heart Lung 2016;45:525-31.

44. Hellewell S, Semple BD, Morganti-Kossmann MC. Therapies negating neuroinflammation after brain trauma. Brain Res 2016;1640:36-56.

45. Hodges A, Pilcher D. Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure. N Engl J Med 2016;374:688.

46. Hodgson C, Cuthbertson BH. Improving outcomes after critical illness: harder than we thought! Intensive Care Med 2016;42:1772-4.

47. Hodgson C, Goligher EC, Young ME, Keating JL, Holland AE, Romero L, Bradley SJ, Tuxen D. Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation. Cochrane Database Syst Rev 2016;11:CD006667.

48. Hodgson CL, Bailey M, Bellomo R, Berney S, Buhr H, Denehy L, Gabbe B, Harrold M, Higgins A, Iwashyna TJ, Papworth R, Parke R, Patman S, Presneill J, Saxena M, Skinner E, Tipping C, Young P, Webb S. A Binational Multicenter Pilot Feasibility Randomized Controlled Trial of Early Goal-Directed Mobilization in the ICU. Crit Care Med 2016;44:1145-52.

49. Hodgson CL, Fan E. Better Measures, Better Trials, Better Outcomes in Survivors of Critical Illness. Crit Care Med 2016;44:1254-5.

50. Hodgson CL, Fan E. Intensive care unit acquired weakness. Anaesthesia and Intensive Care Medicine 2016;17:24-6.

51. Hodgson CL, Iwashyna TJ, Schweickert WD. All That Work and No Gain: What Should We Do to Restore Physical Function in Our Survivors? Am J Respir Crit Care Med 2016;193:1071-2.

52. Iwashyna TJ, Deane AM. Individualizing endpoints in randomized clinical trials to better inform individual patient care: the TARGET proposal. Crit Care 2016;20:218.

53. Iwashyna TJ, Hodgson CL. Early mobilisation in ICU is far more than just exercise. Lancet 2016;388:1351-2.

54. Iwashyna TJ, Hodgson CL, Pilcher D, Bailey M, van Lint A, Chavan S, Bellomo R. Timing of onset and burden of persistent critical illness in Australia and New Zealand: a retrospective, population-based, observational study. Lancet Respir Med 2016;4:566-73.

55. Iwashyna TJ, Speelmon EC. Advancing a Third Revolution in Critical Care. Am J Respir Crit Care Med 2016;194:782-3.

56. Jones D, DeVita M, Warrillow S. Ten clinical indicators suggesting the need for ICU admission after Rapid Response Team review. Intensive Care Med 2016;42:261-3.

57. Jones D, Rubulotta F, Welch J. Rapid response teams improve outcomes: yes. Intensive Care Med 2016;42:593-5.

58. Kar P, Plummer MP, Bellomo R, Jenkins AJ, Januszewski AS, Chapman MJ, Jones KL, Horowitz M, Deane AM. Liberal Glycemic Control in Critically Ill Patients With Type 2 Diabetes: An Exploratory Study. Crit Care Med 2016;44:1695-703.

59. Kellum JA, Bellomo R, Ronco C. Does this patient have acute kidney injury? An AKI checklist. Intensive Care Med 2016;42:96-9.

60. Kirkegaard H, Pedersen AR, Pettila V, Hjort J, Rasmussen BS, de Haas I, Nielsen JF, Ilkjaer S, Kaltoft A, Jeppesen AN, Grejs AM, Duez CH, Larsen AI, Toome V, Arus U, Taccone FS, Storm C, Laitio T, Skrifvars MB, Soreide E. A statistical analysis protocol for the time-differentiated target temperature management after out-of-hospital cardiac arrest (TTH48) clinical trial. Scand J Trauma Resusc Emerg Med 2016;24:138.

61. Kowalski M, Udy AA, McRobbie HJ, Dooley MJ. Nicotine replacement therapy for agitation and delirium management in the intensive care unit: a systematic review of the literature. J Intensive Care 2016;4:69.

62. Lankadeva YR, Kosaka J, Evans RG, Bailey SR, Bellomo R, May CN. Intrarenal and urinary oxygenation during norepinephrine resuscitation in ovine septic acute kidney injury. Kidney Int 2016;90:100-8.

63. Levkovich BJ, Bui T, Bovell A, Watterson J, Egan A, Poole SG, Dooley MJ. Variability of intravenous medication preparation in Australian and New Zealand intensive care units. J Eval Clin Pract 2016;22:965-70.

64. Lipcsey M, Subiakto I, Chiong J, Kaufman MA, Schneider AG, Bellomo R. Epidemiology of secondary fluid bolus therapy for infection-associated hypotension. Crit Care Resusc 2016;18:165-73.

65. Litton E, Baker S, Erber WN, Farmer S, Ferrier J, French C, Gummer J, Hawkins D, Higgins A, Hofmann A, De Keulenaer B, McMorrow J, Olynyk JK, Richards T, Towler S, Trengove R, Webb S. Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial : A randomized trial of IV iron in critical illness. Intensive Care Med 2016;42:1715-22.

66. Luethi N, Cioccari L, Crisman M, Bellomo R, Eastwood GM, Martensson J. Prevalence of ketosis, ketonuria, and ketoacidosis during liberal glycemic control in critically ill patients with diabetes: an observational study. Crit Care 2016;20:297.

67. Luethi N, Cioccari L, Tanaka A, Kar P, Giersch E, Deane AM, Martensson J, Bellomo R. Glycated Hemoglobin A1c Levels Are Not Affected by Critical Illness. Crit Care Med 2016;44:1692-4.

1918

Publications (continued)

Journal Publications (continued)68. Martensson J, Jonsson N, Glassford NJ, Bell M, Martling CR,

Bellomo R, Larsson A. Plasma endostatin may improve acute kidney injury risk prediction in critically ill patients. Ann Intensive Care 2016;6:6.

69. McCaffrey J, Orford NR, Simpson N, Jenkins JL, Morley C, Pellegrino V. Service delivery model of extracorporeal membrane oxygenation in an Australian regional hospital. Crit Care Resusc 2016;18:235-41.

70. McGuinness SP, Parke RL, Drummond K, Willcox T, Bailey M, Kruger C, Baker M, Cowdrey KA, Gilder E, McCarthy L, Painter T. A Multicenter, Randomized, Controlled Phase IIb Trial of Avoidance of Hyperoxemia during Cardiopulmonary Bypass. Anesthesiology 2016;125:465-73.

69. McQuilten ZK, Zatta AJ, Andrianopoulos N, Aoki N, Stevenson L, Badami KG, Bird R, Cole-Sinclair MF, Hurn C, Cameron PA, Isbister JP, Phillips LE, Wood EM. Evaluation of clinical coding data to determine causes of critical bleeding in patients receiving massive transfusion: a bi-national, multicentre, cross-sectional study. Transfus Med 2016;epub.

70. Mikkelsen ME, Jackson JC, Hopkins RO, Thompson C, Andrews A, Netzer G, Bates DM, Bunnell AE, Christie LM, Greenberg SB, Lamas DJ, Sevin CM, Weinhouse G, Iwashyna TJ. Peer Support as a Novel Strategy to Mitigate Post-Intensive Care Syndrome. AACN Adv Crit Care 2016;27:221-9.

71. Mitric G, Udy A, Bandeshe H, Clement P, Boots R. Variable use of amiodarone is associated with a greater risk of recurrence of atrial fibrillation in the critically ill. Crit Care 2016;20:90.

72. Moore EM, Tobin A, Reid D, Bellomo R. Reply: AKI Classification: One Size Doesn’t Fit All. J Cardiothorac Vasc Anesth 2016;30:e36-7.

73. Mora JC, Schneider A, Robbins R, Bailey M, Bebee B, Hsiao YF, Considine J, Jones D, Bellomo R. Epidemiology of early Rapid Response Team activation after Emergency Department admission. Australas Emerg Nurs J 2016;19:54-61.

74. Myles PS, Smith JA, Forbes A, Silbert B, Jayarajah M, Painter T, Cooper DJ, Marasco S, McNeil J, Bussières JS, Wallace S. Stopping vs. Continuing Aspirin Before Coronary Artery Surgery. N Engl J Med 2016;374:728-37.

75. Neri M, Villa G, Garzotto F, Bagshaw S, Bellomo R, Cerda J, Ferrari F, Guggia S, Joannidis M, Kellum J, Kim JC, Mehta RL, Ricci Z, Trevisani A, Marafon S, Clark WR, Vincent JL, Ronco C. Nomenclature for renal replacement therapy in acute kidney injury: basic principles. Crit Care 2016;20:318.

76. Oldroyd JC, Venardos KM, Aoki NJ, Zatta AJ, McQuilten ZK, Phillips LE, Andrianopoulos N, Cooper DJ, Cameron PA, Isbister JP, Wood EM. Improving outcomes for hospital patients with critical bleeding requiring massive transfusion: the Australian and New Zealand Massive Transfusion Registry study methodology. BMC Res Notes 2016;9:457.

77. Orford NR, Lane SE, Bailey M, Pasco JA, Cattigan C, Elderkin T, Brennan-Olsen SL, Bellomo R, Cooper DJ, Kotowicz MA. Changes in Bone Mineral Density in the Year after Critical Illness. Am J Respir Crit Care Med 2016;193:736-44.

78. Orford NR, Milnes SL, Lambert N, Berkeley L, Lane SE, Simpson N, Elderkin T, Bone A, Martin P, Corke C, Bellomo R, Bailey M. Prevalence, goals of care and long-term outcomes of patients with life-limiting illness referred to a tertiary ICU. Crit Care Resusc 2016;18:181-8.

79. Ou L, Chen J, Burrell T, Flabouris A, Hillman K, Bellomo R, Parr M. Incidence and mortality of postoperative sepsis in New South Wales, Australia, 2002-2009. Crit Care Resusc 2016;18:9-16.

80. Panwar R, Hardie M, Bellomo R, Barrot L, Eastwood GM, Young PJ, Capellier G, Harrigan PW, Bailey M. Conservative versus Liberal Oxygenation Targets for Mechanically Ventilated Patients. A Pilot Multicenter Randomized Controlled Trial. Am J Respir Crit Care Med 2016;193:43-51.

81. Paul E, Bailey M, Kasza J, Pilcher D. The ANZROD model: better benchmarking of ICU outcomes and detection of outliers. Crit Care Resusc 2016;18:25-36.

82. Philpot SJ, Aranha S, Pilcher DV, Bailey M. Randomised, Double Blind, Controlled Trial of the Provision of Information about the Benefits of Organ Donation during a Family Donation Conversation. PLoS One 2016;11:e0155778.

83. Pisano A, Landoni G, Bellomo R. The risk of infusing gelatin? Die-hard misconceptions and forgotten (or ignored) truths. Minerva Anestesiol 2016;82:1107-14.

84. Prescott HC, Osterholzer JJ, Langa KM, Angus DC, Iwashyna TJ. Late mortality after sepsis: propensity matched cohort study. BMJ 2016;353:i2375.

85. Raj R, Bendel S, Reinikainen M, Hoppu S, Luoto T, Ala-Kokko T, Tetri S, Laitio R, Koivisto T, Rinne J, Kivisaari R, Siironen J, Skrifvars MB. Traumatic brain injury patient volume and mortality in neurosurgical intensive care units: a Finnish nationwide study. Scand J Trauma Resusc Emerg Med 2016;24:133.

86. Ramanan M, Myburgh J, Finfer S, Bellomo R, Venkatesh B. Publication of Secondary Analyses from Randomized Trials in Critical Care. N Engl J Med 2016;375:2105-6.

87. Ramos JG, Teles Correa MD, de Carvalho RT, Jones D, Forte DN. Clinical significance of palliative care assessment in patients referred for urgent intensive care unit admission: A cohort study. J Crit Care 2016;37:24-9.

88. Reade MC, Bailey M, Bellomo R. Dexmedetomidine to Reduce Intubation Time in Patients With Agitated Delirium--Reply. JAMA 2016;316:773-4.

89. Reade MC, Eastwood GM, Bellomo R, Bailey M, Bersten A, Cheung B, Davies A, Delaney A, Ghosh A, van Haren F, Harley N, Knight D, McGuiness S, Mulder J, O’Donoghue S, Simpson N, Young P. Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial. JAMA 2016;315:1460-8.

90. Reddy S, Bailey M, Beasley R, Bellomo R, Mackle D, Psirides A, Young P. Effect of saline 0.9% or Plasma-Lyte 148 therapy on feeding intolerance in patients receiving nasogastric enteral nutrition. Crit Care Resusc 2016;18:198-204.

91. Reid DB, Chapple LS, O’Connor SN, Bellomo R, Buhr H, Chapman MJ, Davies AR, Eastwood GM, Ferrie S, Lange K, McIntyre J, Needham DM, Peake SL, Rai S, Ridley EJ, Rodgers H, Deane AM. The effect of augmenting early nutritional energy delivery on quality of life and employment status one year after ICU admission. Anaesth Intensive Care 2016;44:406-12.

92. Reith FC, Van den Brande R, Synnot A, Gruen R, Maas AI. The reliability of the Glasgow Coma Scale: a systematic review. Intensive Care Med 2016;42:3-15.

93. Ridgeon E, Bellomo R, Myburgh J, Saxena M, Weatherall M, Jahan R, Arawwawala D, Bell S, Butt W, Camsooksai J, Carle C, Cheng A, Cirstea E, Cohen J, Cranshaw J, Delaney A, Eastwood G, Eliott S, Franke U, Gantner D, Green C, Howard-Griffin R, Inskip D, Litton E, MacIsaac C, McCairn A, Mahambrey T, Moondi P, Newby L, O’Connor S, Pegg C, Pope A, Reschreiter H, Richards B, Robertson M, Rodgers H, Shehabi Y, Smith I, Smith J, Smith N, Tilsley A, Whitehead C, Willett E, Wong K, Woodford C, Wright S, Young P. Validation of a classification system for causes of death in critical care: an assessment of inter-rater reliability. Crit Care Resusc 2016;18:50-4.

94. Ridgeon EE, Young PJ, Bellomo R, Mucchetti M, Lembo R, Landoni G. The authors reply. Crit Care Med 2016;44:e1143.

95. Ridgeon EE, Young PJ, Bellomo R, Mucchetti M, Lembo R, Landoni G. The Fragility Index in Multicenter Randomized Controlled Critical Care Trials. Crit Care Med 2016;44:1278-84.

96. Ridley E, Gantner D, Pellegrino V. Reply Letter to the Editor - Nutrition therapy in critically ill patients - A review of current


evidence for clinicians. Clin Nutr 2016;35:244.97. Ristagno G, Masson S, Tiainen M, Bendel S, Bernasconi R,

Varpula T, Milani V, Vaahersalo J, Magnoli M, Spanuth E, Barlera S, Latini R, Hoppu S, Pettila V, Skrifvars MB. Elevated plasma heparin-binding protein is associated with early death after resuscitation from cardiac arrest. Crit Care 2016;20:251.

98. Roberts JA, Abdul-Aziz MH, Davis JS, Dulhunty JM, Cotta MO, Myburgh J, Bellomo R, Lipman J. Continuous versus Intermittent beta-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials. Am J Respir Crit Care Med 2016;194:681-91.

99. Rozencwajg S, Pilcher D, Combes A, Schmidt M. Outcomes and survival prediction models for severe adult acute respiratory distress syndrome treated with extracorporeal membrane oxygenation. Crit Care 2016;20:392.

100. Sanagou M, Leder K, Cheng AC, Pilcher D, Reid CM, Wolfe R. Associations of hospital characteristics with nosocomial pneumonia after cardiac surgery can impact on standardized infection rates. Epidemiol Infect 2016;144:1065-74.

101. Serpa Neto A, Schmidt M, Azevedo LC, Bein T, Brochard L, Beutel G, Combes A, Costa EL, Hodgson C, Lindskov C, Lubnow M, Lueck C, Michaels AJ, Paiva JA, Park M, Pesenti A, Pham T, Quintel M, Marco Ranieri V, Ried M, Roncon-Albuquerque R, Jr., Slutsky AS, Takeda S, Terragni PP, Vejen M, Weber-Carstens S, Welte T, Gama de Abreu M, Pelosi P, Schultz MJ. Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis : Mechanical ventilation during ECMO. Intensive Care Med 2016;42:1672-84.

102. Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, Rubenfeld G, Kahn JM, Shankar-Hari M, Singer M, Deutschman CS, Escobar GJ, Angus DC. Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016;315:762-74.

103. Shields N, Synnot A. Perceived barriers and facilitators to participation in physical activity for children with disability: a qualitative study. BMC Pediatr 2016;16:9.

104. Sidiropoulos S, Treasure E, Silvester W, Opdam H, Warrillow SJ, Jones D. Organ donation after circulatory death in a university teaching hospital. Anaesth Intensive Care 2016;44:477-83.

105. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016;315:801-10.

106. Sjoding MW, Cooke CR, Iwashyna TJ, Hofer TP. Acute Respiratory Distress Syndrome Measurement Error. Potential Effect on Clinical Study Results. Ann Am Thorac Soc 2016;13:1123-8.

107. Sjoding MW, Prescott HC, Wunsch H, Iwashyna TJ, Cooke CR. Longitudinal Changes in ICU Admissions Among Elderly Patients in the United States. Crit Care Med 2016;44:1353-60.

108. Sjoding MW, Valley TS, Prescott HC, Wunsch H, Iwashyna TJ, Cooke CR. Rising Billing for Intermediate Intensive Care among Hospitalized Medicare Beneficiaries between 1996 and 2010. Am J Respir Crit Care Med 2016;193:163-70.

109. Synnot A, Gruen RL, Menon D, Steyerberg EW, Buki A, Peul WC, Elliott JH, Maas A. A New Approach to Evidence Synthesis in Traumatic Brain Injury: A Living Systematic Review. J Neurotrauma 2016;epub.

110. Tatucu-Babet OA, Ridley EJ, Tierney AC. Prevalence of Underprescription or Overprescription of Energy Needs in Critically Ill Mechanically Ventilated Adults as Determined by Indirect Calorimetry: A Systematic Literature Review. JPEN J Parenter Enteral Nutr 2016;40:212-25.

111. Taylor C, Thompson K, Finfer S, Higgins A, Jan S, Li Q, Liu B, Myburgh J. Hydroxyethyl starch versus saline for resuscitation of patients in intensive care: long-term outcomes and cost-effectiveness analysis of a cohort from CHEST. Lancet Respir Med 2016;4:818-25.

112. Tipping CJ, Bailey MJ, Bellomo R, Berney S, Buhr H, Denehy L, Harrold M, Holland A, Higgins AM, Iwashyna TJ, Needham D, Presneill J, Saxena M, Skinner EH, Webb S, Young P, Zanni J, Hodgson CL. The ICU Mobility Scale Has Construct and Predictive Validity and Is Responsive. A Multicenter Observational Study. Ann Am Thorac Soc 2016;13:887-93.

113. Tiruvoipati R, Buscher H, Winearls J, Breeding J, Ghosh D, Chaterjee S, Braun G, Paul E, Fraser JF, Botha J. Early experience of a new extracorporeal carbon dioxide removal device for acute hypercapnic respiratory failure. Crit Care Resusc 2016;18:261-9.

114. Toonstra AL, Nelliot A, Aronson Friedman L, Zanni JM, Hodgson C, Needham DM. An evaluation of learning clinical decision-making for early rehabilitation in the ICU via interactive education with audience response system. Disabil Rehabil 2016:1-3.

115. Topple M, Ryan B, Baldwin I, McKay R, Blythe D, Rogan J, Radford S, Jones D. Tasks completed by nursing members of a teaching hospital Medical Emergency Team. Intensive Crit Care Nurs 2016;32:12-9.

116. Topple M, Ryan B, McKay R, Blythe D, Rogan J, Baldwin I, Jones D. Features of an Intensive Care based Medical Emergency Team nurse training program in a University Teaching Hospital. Aust Crit Care 2016;29:46-9.

117. Tramm R, Ilic D, Hodgson C, Murphy K, Sheldrake J, Pellegrino V. Experience and needs of family members of patients treated with extracorporeal membrane oxygenation (ECMO). J Clin Nurs 2016;epub.

118. Tramm R, Ilic D, Murphy K, Sheldrake J, Pellegrino V, Hodgson C. A qualitative exploration of acute care and psychological distress experiences of ECMO survivors. Heart Lung 2016;45:220-6.

119. Udy AA, Scheinkestel C, Pilcher D, Bailey M. The Association Between Low Admission Peak Plasma Creatinine Concentration and In-Hospital Mortality in Patients Admitted to Intensive Care in Australia and New Zealand. Crit Care Med 2016;44:73-82.

120. Urbancic KF, Robbins R, Glassford NJ. Complications of Central Venous Catheterization. N Engl J Med 2016;374:1489-90.

121. Villa G, Neri M, Bellomo R, Cerda J, De Gaudio AR, De Rosa S, Garzotto F, Honore PM, Kellum J, Lorenzin A, Payen D, Ricci Z, Samoni S, Vincent JL, Wendon J, Zaccaria M, Ronco C. Nomenclature for renal replacement therapy and blood purification techniques in critically ill patients: practical applications. Crit Care 2016;20:283.

122. Warrillow S, Farley KJ, Jones D. How to improve communication quality with patients and relatives in the ICU. Minerva Anestesiol 2016;82:797-803.

123. Warrillow S, Moran J, Jones D. Experience and outcomes for relatives of patients dying in the ICU: the CAESAR tool. J Thorac Dis 2016;8:E611-4.

124. Weber U, Glassford NJ, Eastwood GM, Bellomo R, Hilton AK. A Pilot Assessment of Carotid and Brachial Artery Blood Flow Estimation Using Ultrasound Doppler in Cardiac Surgery Patients. J Cardiothorac Vasc Anesth 2016;30:141-8.

125. Wendon J, Hodgson C, Bellomo R. Rapid response teams improve outcomes: we are not sure. Intensive Care Med 2016;42:599-601.

126. Wong SW, Gantner D, McGloughlin S, Leong T, Worth LJ, Klintworth G, Scheinkestel C, Pilcher D, Cheng AC, Udy AA. The influence of intensive care unit-acquired central line-

Journal Publications (continued)

2120


associated bloodstream infection on in-hospital mortality: A single-center risk-adjusted analysis. Am J Infect Control 2016;44:587-92.

127. Yong SA, D’Souza S, Philpot S, Pilcher DV. The Alfred Hospital experience of resumption of cardiac activity after withdrawal of life-sustaining therapy. Anaesth Intensive Care 2016;44:605-6.

128. Young P, Bailey M, Bellomo R. Acute Kidney Injury With Buffered Crystalloids vs Saline Among ICU Patients--Reply. JAMA 2016;315:1521.

129. Zhang L, Diao Y, Chen G, Tanaka A, Eastwood GM, Bellomo R. Remote ischemic conditioning for kidney protection: A meta-analysis. J Crit Care 2016;33:224-32.

Book Chapters130. Hodgson CL, Fan E. Chapter: ICU acquired weakness and

early mobilization. In: Oropello J, Kvetan V, Pastores SM, eds. Lange Critical Care Medicine (ISBN: 9780071820813). 4th ed: McGraw-Hill Education; 2016.

131. Hodgson CL, Watts NM, Iwashyna TJ. Long-TermOutcomes After Critical Illness Relevant to Randomized Clinical Trials. In: Vincent J-L, ed. Annual Update in Intensive Care and Emergency Medicine 2016 (ISBN: 978-3-319-27348-8). Switzerland: Springer International Publishing; 2016:465-74.

132. Iwashyna TJ, Cooke CR. Chapter 6: Regional critical care delivery systems. In: Webb A, Angus D, Finfer S, Gattinoni L, Singer M, eds. Oxford Textbook of Critical Care (ISBN: 9780199600830). 2nd ed: Oxford University Press; 2016.

133. Jaderling G, Bellomo R. Chapter 5: Do Early Warning Scores and Rapid Response Teams Improve Outcomes? In: Deutschman CS, Neligan PJ, eds. Evidence-based practice of critical care, 2nd edition (ISBN 9780323299954). Philadelphia, PA: Elsevier; 2016:pp 21-30.

134. Martensson J, Bellomo R. Chapter: Pathophysiology of Septic Acute Kidney Injury. In: Ding X, Ronco C, eds. Acute Kidney Injury - From Diagnosis to Care (ISBN: 978-3-318-05825-3). Basel: Karger; 2016.

135. Martensson J, Bellomo R. Chapter: The Rationale for Permissive Hyperglycemia in Critically Ill Patients with Diabetes. In: Vincent J-L, ed. Annual Update in Intensive Care and Emergency Medicine 2016 (ISBN: 978-3-319-27348-8). Switzerland: Springer International Publishing; 2016:365-72.

136. Nichol A, Duff S, Pettila V, Cooper DJ. Chapter 9: What is the Optimal Approach to Weaning and Liberation from Mechanical Ventilation? In: Deutschman CS, Neligan PJ, eds. Evidence-based practice of critical care, 2nd edition (ISBN 9780323299954). Philadelphia, PA: Elsevier; 2016:pp 52-60.

137. Peake SL, Maiden MJ. Chapter 298: Management of septic shock in the critically ill. In: Webb A, Angus D, Finfer S, Gattinoni L, Singer M, eds. Oxford Textbook of Critical Care (ISBN: 9780199600830). 2nd ed: Oxford University Press; 2016.

Open Access1. Hastings JR, Nickson CP, Udy AA. Alfred ICU Journal Club

Review of “Pickard et al, 1989: British aneurysm nimodipine trial”. The Winnower 2016;3:e146976.62390.

2. Hung M, Burrell A, Nickson CP. Alfred ICU Journal Club Review of “Laursen CB, et al. Point-of-care ultrasonography in patients admitted with respiratory symptoms: a single-blind, randomised controlled trial”. The Winnower 2016;3:e146449.93098.

3. Phua V, Udy AA, Nickson CP. Alfred ICU Journal Club Review of “Bhullar et al, 2014: antiseizure prophylaxis after Traumatic Brain Injury”. The Winnower 2016;3:e146976.61808

Journal Publications (continued)

Presentations - National / International Month Conference Location Name Title Role/s

Feb 12th Symposium of the International Neurotrauma Society

Cape Town, South Africa

Cooper DJ 1. Clinical trial design: Lessons learned2. Results of the ANZIC randomized

controlled trial of EPO

Invited Presenter

Feb International ECMO Network Rome, Italy Hodgson C Physical therapy during ECMO Invited Presenter/Chair

Mar Intensive Care Research Coordinator Interest Group Workshop (IRCIG)

Noosa, Australia Eastwood G 1. Research terminology: Language for the road

2. Session 3 (Chair)

Invited Presenter /Chair

Mar IRCIG Workshop Noosa, Australia Little L EPO-TBI blinding plan and development of placebo

Invited Presenter

Mar IRCIG Workshop Noosa, Australia McGuinness S

Writing a research grant application Invited Presenter

Mar IRCIG Workshop Noosa, Australia Parke R 1. Session 1 (Chair)2. Research position descriptions: building

a pathway

Chair

Mar 18th ANZICS-CTG Annual Meeting on Clinical Trials in Intensive Care ( ASM CTIC)

Noosa, Australia Bellomo R STARRT AKI Update Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Cooper DJ POLAR study update Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Eastwood G 1. The TAME cardiac arrest trial2. IRCIG update

Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia French C 1. Session 1 (Chair)2. CTG update3. Platform trials and the Clinical Trials

Group4. EPO-TBI results5. Session 9 (Chair)

Invited Presenter / Chair

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Gantner D PATCH update Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Hodgson C Long-term outcomes working party Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Jones D ANZ-CODE Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Little L National mutual acceptance Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia McQuilten Z 1. TRANSFUSE update2. The FIT study

Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Myburgh J 1. PLUS2. SuDDICU (with Seppelt I)3. Open Access of Investigator-initiated trials

– Lessons from CHEST 4. NSW Guardianship Act Update

Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Nichol A PHARLAP update Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Parke R Session 8 (Chair) Chair

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Peake S 1. Meeting Convenor2. TARGET update

Convenor / Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Pilcher D 1. Results of the linkage study between the APD and the point prevalence study

2. CORE workshop update

Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Presneill J Bayesian versus frequentist statistical analysis Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Seppelt I 1. SuDDICU (with Myburgh J)2. Point Prevalence Program update

Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Shehabi Y 1. SPICE update2. SPICE-HEART

Invited Presenter

Mar 18th ANZICS-CTG ASM CTIC Noosa, Australia Webb S 1. SPRINT-SARI2. Principles of platform trials 3. Results of the ACTA Profiling Network

Project

Invited Presenter

Mar 18th ANZICS-CTG: Pre-clinical Research Meeting

Noosa, Australia Bellomo R Paracetamol IV study in healthy volunteers Invited Presenter / Chair

2322

Presentations - National / International (continued)Presentations - National / International (continued)

Month Conference Location Name Title Role/s

Aug ANZICS-CTG Winter Forum Coogee, Australia Gantner D EPO-TBI substudies Invited Presenter

Aug ANZICS-CTG Winter Forum Coogee, Australia Hodgson C ICU-Recovery Invited Presenter

Aug ANZICS-CTG Winter Forum Coogee, Australia Pilcher D CORE update Invited Presenter

Aug ANZICS-CTG Winter Forum Coogee, Australia Udy A 1. LIBERTY trial2. PROMOTE-SAH

Invited Presenter

Aug ASM of the SCCM of the Chinese PLA

Nanjing,China

Bellomo R 1. What is the correct glucose target in diabetics2. Long-term outcomes in critical illness3. RRT modality and renal recovery4. Fluid bolus therapy in 2016

Invited Presenter

Aug Perfusion Down Under Queenstown, New Zealand

Bellomo R 1. Magnesium therapy in cardiac surgery and ICU2. What is the correct glucose target in diabetics”

Invited Presenter

Sep HRB Clinical Research Coord Dublin, Ireland Nichol A Irish Critical Care Clinical Trials Invited Presenter

Oct 41st ANZICS/ACCCN Intensive Care Annual Scientific Meeting (ICM ASM)

Perth, Australia Burrell A 1. Who should get ECMO?2. eC02 removal: Should it be done in a non-ECMO

centre? (Panel)3. Type of hospital impacts Intensive Care length

of stay: An analysis of the ANZICS Adult Patient Database

Invited Presenter / Panel Member

Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Chapman M Feeding targets Invited Presenter

Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Davies A Micronutrients Invited Presenter

Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Eastwood G Conservative oxygen therapy in cardiac surgery Invited Presenter

Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia French C 1. Building a research portfolio (Panel)2. Novel trial designs3. Medical debate: That the part-time intensivist

will be the death of intensive care medicine


Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Huckson S, van Lint A

The arrival of COMET Invited Presenters

Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Jones D MET systems Invited Presenter

Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Kruger P Chlorhexidine Mouthwash In Intubated Intensive Care Patients

Invited Presenter

Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Levkovich B 1. Workforce: Allied Health perspective2. Workforce: Burnout (Panel)


Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia McGuinness S

1. ECMO retrieval2. eC02 removal: Should it be done in a non-ECMO

centre? (Panel)

Invited Presenter

Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Parke R 1. ECMO circuit maintenance2. eC02 removal: Should it be done in a non-ECMO

centre? (Panel)

Invited Presenter

Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Peake S Life after ARISE - future sepsis research Invited Presenter

Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Pilcher D 1. Year 2025: Sepsis and the future of your ICU2. Estimating risk of death using data available

only on admission to Intensive Care: Development and validation of the ANZROD admission model

Invited Presenter

Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Reade M 1. Sedation, delirium and ICU outcomes (Panel)2. Fluids (Panel)3. DAHLIA4. The critical care journey of the battle casualty


Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Seppelt I 1. Fluids (Panel)2. Major papers of the last 2 years


Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Tiruvoipati R Intensive Care discharge delay is associated with increased hospital length of stay

Invited Presenter

Oct 41st ANZICS/ACCCN ICM ASM Perth, Australia Webb S 1. How to get into research2. Building a research portfolio (Panel)3. Pandemics: Are we really prepared? (Panel)


Oct 1st National (Ireland) ICU Audit Conference

Dublin, Ireland Nichol A Big data: use of the Irish audit database Invited Presenter

Month Conference Location Name Title Role/s

Mar 18th ANZICS-CTG: Pre-clinical Research Meeting

Noosa, Australia McArthur C Ethical considerations in research involving healthy volunteers


Mar 36th International Symposium on Intensive Care and Emergency Medicine

Brussels, Belgium Bellomo R 1. EPO in TBI2. Functional renal reserve3. Renal oxygen delivery4. Fluid resuscitation: dry vs wet5. Mobilization in ICU6. Plasmalyte in major surgery7. Hypercapnia in cardiac arrest8. Delayed MET activation9. Continuous vs intermittent antibiotics

Invited Presenter

Apr Enhance Recovery After Surgery (ERAS) Conference

Lisbon, Portugal Bellomo R 1. Urinary output in post-operative patients2. Dogmas in IV fluids3. Management of diabetes

Invited Plenary / Presenter

May 12th International Conference on Rapid Response Systems

Melbourne, Australia Bellomo R 1. Where should we focus training2. Laboratory Test Results as Calling Criteria

Invited Presenter

May 12th ICRRS Melbourne, Australia Davies A Recognising deterioration in pregnancy Chair

May 12th ICRRS Melbourne, Australia Jones D 1. Concept of Acute End of Life Care (EoLC) in Hospitalised Patients

2. An overview of the ANZICS course

Conference Convenor / Presenter / Chair

May 12th ICRRS Melbourne, Australia Orford N Improving the Recognition of the DyingPatient - Video EoLC Discussion/Debrief

Invited Presenter

May 12th ICRRS Melbourne, Australia Pilcher D Predicting the Need For Medical Emergency Response in Patients Discharged From ICU at the Alfred Hospital

Invited Presenter

May Amercian Thoracic Society International Conference

San Francisco, USA Hodgson C Five hammers for one nail Invited Presenter/ Panel Member

May Amercian Thoracic SocietyInternational Conference

San Francisco, USA Nichol A PREPAREing for future epidemics: Platform trial with adaptive randomization

Invited Presenter

May Baxter Healthcare ICU Nutrition Symposium

Sydney, Australia Ridley E Indirect calorimetry in ICU Invited Presenter

Jun 2nd Scandinavian Intensive Care Meeting

Helsinki, Finland Bellomo R 1. Long term outcome after critical illness2. How should I manage AKI to improve

outcomes3. How to design clinical studies better

Invited Plenary / Presenter

Jun AuSPEN Advanced Clinical Nutrition Course

Sydney, Australia Ridley E 1. Nutrition requirements for the compromised patient including overfeeding

2. Critical appraisal in nutrition support

Invited Presenter

Jun Critical Care Nephrology Conference

Vicenza, Italy Bellomo R 1. Septic AKI: pathophysiology2. Adaptive and maladaptive repair after AKI

Invited Presenter

Jun Irish Critical Care Clinical Trials Group / Research Network

Dublin, Ireland Nichol A 1. Clinical research in the ICU2. Establishing an effective clinical trials group

Convenor / Presenter

Jun smaccDUB Dublin, Ireland Myburgh J Does oxygen delivery matter? Invited Presenter

Jun smaccDUB Dublin, Ireland Nichol A Cooling the injured brain Invited Presenter

Jun smaccDUB Dublin, Ireland Rowan K Fragility index Invited Presenter

Jun smaccDUB Dublin, Ireland Udy A Getting our patients (and us) home Chair

Jun Symposium on Acute Kidney Injury and Recovery

Paris, France Bellomo R 1. Choice of initial RRT modality: clinical impact

2. Post-AKI long-term dialysis dependence: cost implications

Invited Presenter

Jun UK Critical Care Research Forum

Newcastle, UK Nichol A Irish Critical Care Clinical Trials Invited Presenter

Jul 10th Alfred ICU Advanced MV Conference

Melbourne, Australia Hodgson C Strategies to improve outcome after mechanical ventilation


Jul 10th Alfred ICU AMV Conference

Melbourne, Australia Ridley E How indirect calorimetry can benefit patients in ICU

Invited Presenter

Jul ICU Physiotherapy Symposium Melbourne, Australia Hodgson C Early mobilisation in ICU Invited Presenter / Chair

Australian and New Zealand Intensive Care Research Centre

553 St Kilda RoadMelbourne, Victoria, Australia 3004

anzicrc.monash.org

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