1

August 3, 2015

Curriculum Vitae

Name: Jack Jacek Hawiger Address: Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine T-1218 Medical Center North Nashville, TN 37232-2363 Phone: (615) 343-8280 Fax: (615) 343-8278 Email: jacek.hawiger@vanderbilt.edu Place of Birth: Cracow, Poland (U.S. citizen by naturalization) Family: Mother: Adela Hawiger-Kowalczuk (small business owner, d. 8/13/1996) Father: Roman Hawiger (insurance adjuster d. 9/19/1942 as a political prisoner in the Auschwitz Concentration Camp). Wife: Joanna (Ania) Hawiger, M.D. Children: Marcel Müeller Hawiger Alexander Roman Hawiger Adam Jacek Hawiger Degrees: 1955 Baccalaureate Mickiewicz's Lyceum, Katowice, Poland 1962 M.D. Copernicus School of Medicine, Cracow, Poland 1967 Ph.D. National Institute of Public Health, Warsaw, Poland Graduate Studies in Medical Microbiology (1964-1967) 1987 M.A. (honorary) Harvard University, Cambridge, Massachusetts 1992 M.D. (honorary) Copernicus School of Medicine, Cracow, Poland Postdoctoral Training: Internship and Residencies: 1961-1962 Intern (Rotating), Copernicus School of Medicine Hospital,

Cracow, Poland, and Department of Medicine, University of Paris, Paris, France

2

1962-1963 Resident, Department of Medicine, Copernicus School of Medicine Hospital, Cracow, Poland Research Fellowships: 1967-1969 Postdoctoral Fellow, Division of Infectious Diseases, Department of Medicine, Vanderbilt University, Nashville, Tennessee (Drs. David E. Rogers and M. Glenn Koenig, Mentors) Licensure and Certification: 1973 Medical License of the State of Tennessee 1979 Medical License of the Commonwealth of Massachusetts Academic Appointments: 1969-1974 Assistant Professor of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 1974-1978 Associate Professor of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 1975-1978 Associate Professor of Pathology, Vanderbilt University School

of Medicine, Nashville, Tennessee 1978 Professor of Pathology and Medicine, Vanderbilt University

School of Medicine, Nashville, Tennessee 1978-79 Professor of Medicine, Boston University School of Medicine,

Boston, Massachusetts 1979-1982 Professor of Pathology and Medicine, Vanderbilt University

School of Medicine, Nashville, Tennessee 1983-1985 Associate Professor of Medicine, Harvard Medical School,

Boston, Massachusetts 1985-1990 Professor of Medicine (tenure of unlimited duration, 1987),

Harvard Medical School, Boston, Massachusetts 1990-2002 Oswald T. Avery Professor and Chairman, Department of

Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee

3

2002-2011 Oswald T. Avery Distinguished Professor and Chairman,

Department of Microbiology and Immunology, Vanderbilt University School of Medicine

2011- Present Distinguished Professor of Medicine and Louise B. McGavock

Chair in Medicine, Vanderbilt University School of Medicine 2011-Present Professor of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine Hospital Appointments: 1974-1975 Physician/Research & Education Associate, Veterans

Administration Hospital, Nashville, Tennessee 1976-1978 Active Staff, Vanderbilt University Hospital, Nashville,

Tennessee 1976-1978 Visiting Staff, Veterans Administration Hospital, Nashville,

Tennessee 1978-1979 Chief, Hemostasis Section, Veterans Administration Hospital,

Boston, Massachusetts 1979-1982 Active Staff, Vanderbilt University Hospital, Nashville,

Tennessee 1983-1989 Active Staff, New England Deaconess Hospital, Boston,

Massachusetts 1983-1989 Director, Division of Experimental Medicine, Department of

Medicine, New England Deaconess Hospital, Boston, Massachusetts

Other Professional Positions and Major Visiting Appointments: 1977-1978 Visiting Associate Professor of Medicine, University of California

at San Diego, LaJolla, CA (with Drs. Russell F. Doolittle and Samuel Rapaport)

1979-1980 Lecturer in Medicine, Tufts University School of Medicine, Boston, Massachusetts

1990 Visiting Scientist, Whitehead Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts

2002 Visiting Professor, Mario Negri Institute, Bergamo, Italy

4

Awards and Honors: 1967 Award of the Scientific Council of Ministry of Health and Social

Welfare, Warsaw, Poland 1985 Edward Kowalski Award for Outstanding Achievements in

Thrombosis and Hemostasis, Xth International Congress on Thrombosis and Hemostasis, San Diego, CA

1985 Investigator Recognition Award for Contributions to Hemostasis in honor of Birger Blomback, San Diego, CA

1985 Twelfth Annual Patek Lectureship, Boston VA Medical Center and Tufts University School of Medicine

1987 Chairman, Gordon Research Conference on Hemostasis 1987 MERIT Award, National Heart, Lung, and Blood Institute, NIH 1987 Honorary Master of Arts Degree, Harvard University,

Cambridge, MA 1991 Elected to the Polish Academy of Arts and Sciences (Foreign

Member) 1992 Honorary Doctor of Medicine Degree, Copernicus School of

Medicine, Cracow, Poland 1994 Award in Biochemistry, Alfred Jurzykowski Foundation, New

York, New York 1995 Honorary Membership, Polish Society for Atherosclerosis

Research 1997 Special Recognition Award, Council on Arteriosclerosis,

Thrombosis and Vascular Biology, American Heart Association 1998 Bristol-Myers Squibb Plenary Lecture at the Annual Meeting of

the European Society for Clinical Investigation, Cracow, Poland 1998 Fellow, American Academy of Microbiology 2001 M. Glenn Koenig Visiting Professor, Department of Medicine, Vanderbilt University 2002 Faculty Award for Excellence in Teaching, Vanderbilt University Medical Center 2002-2011 Oswald T. Avery Distinguished Professor of Microbiology and Immunology 2005 Ernest W. Goodpasture Award for Outstanding Contributions to Research, Vanderbilt University Medical Center. 2008 Wladyslaw A. Gluzinski Memorial Lecture, the Polish Society of Internal Medicine, Warsaw, Poland 2010 The Jacek Hawiger Award for Excellence in Teaching Graduate

Students and Postdoctoral Fellows established by Vanderbilt University School of Medicine.

2011- Present Louis B. McGavock Endowed Chair in Medicine, Vanderbilt University

2012 The Kosciuszko Foundation’s Collegium of Eminent Scientists 2014 Roger M. Des Prez Lectureship, Department of Medicine,

5

Vanderbilt University Inventions and Patents: 1. Hawiger, J., Timmons, S., Lukas, T.J., Kloczewiak, M., Method of Inhibiting and

Inducing Human Platelet Aggregation. April 28, 1987, United States Patent #4,661,471.

2. Hawiger, J.J., Timmons, S., Kloczewiak M., Method of Inhibiting Binding of Von

Willebrand Factor to Human Platelets and Inducing Interactions of Platelets with Vessel Walls. May 19, 1987. United States Patent #4,666,884.

3. Hawiger, J., Timmons, S., Kloczewiak, M., Method of Producing Biologically Active

Molecules Having Extended Life Time, October 27, 1987, United States Patent #4,703,039.

4. Hawiger, J., Timmons, S., Bednarek, M., Kloczewiak, M., Hybrid Peptides and

Methods of Their Use. November 2, 1989. European Patent #89905845.7. 5. Lin, Y., and Hawiger, J., Method for Importing Biologically Active Molecules into

Cells. September 15, 1998. U.S. Patent #5,807,746. 6. Lin, Y., and Hawiger J., Method for Importing Biologically Active Molecules into Cells.

March 28, 2000. U.S. Patent #6,043,339. 7. Lin, Y., and Hawiger J., Method for Importing Biologically Active Molecules into Cells.

December 17, 2002. U.S. Patent #6,495,518. 8. Hawiger, J., Robinson, D., Veach, R., Liu, X., Liu, D., Timmons, S., Collins, R., Cell

Permeable Peptides for Inhibition of Inflammatory Reactions and Methods of Use. U.S., Canada and Japan Patents applied for.

9. Hawiger, J., Robinson, D., Veach, R., Liu, X., Liu, D., Timmons, S., Collins, R., Cell

Permeable Peptides for Inhibition of Inflammatory Reactions and Methods of Use. August 2, 2006. European Patent #1246616. February 16, 2006. Australian Patent #783,479

10. Hawiger, J., and Jo, D. Cell-Penetrating SOCS Polypeptide that Inhibit Cytokine-

Induced Signaling. U.S. and European Patents Pending. 11. Hawiger, J. Methods for importing biologically active molecules into cells. US Patent

#7576058. August 18, 2009

12. Hawiger, JJ, Moore DJ, Zienkiewicz J, Liu X, Veach RA, Collins RD,.Composition and Methods for Preserving Insulin-Producing Cells and Insulin Production and Treating Diabetes. October 5, 2012, US Patent #13/645,754

6

13. Hawiger, JJ, Liu Y, Major AS, Zienkiewicz, J, Veach RA, Collins RD. Compositions and methods for Treating and Preventing Hyperlipidemia, Fatty Liver, Atherosclerosis and Other Disorders Associated with Metabolic Syndrome. November 13,2014, US Patent# 14/349,918

14. Hawiger, JJ, Zienkiewicz, J. Compositions and Methods for Targeting Nuclear Import Shuttles and Treating Inflammatory Disorders. April 11, 2014 US and European Patents pending

VA Support:

Active:

2015- 2019 Regulation of Innate Immunity and Inflammation through Nuclear Reprogramming. VA MERIT Grant 1IO1 BX002750-01. Direct Costs:$319,929

for first year.

NIH Support: Active: 2002- 2017 Immunobiology of Blood and Vascular Systems Training. National Heart, Lung and Blood Institute Grant 5T32 HL69765-14. Direct Costs: $419,025 per year. J. Hawiger, PI Completed: 2011- 2014 Harnessing B Lymphocytes as Antigen-Specific Regulators of Islet Tolerance. National Institute of Diabetes, Digestive and Kidney Diseases Grant 5 K08 DK 090146-03. Daniel J. Moore, PI; J. Hawiger, Mentor 2013- 2015 The Role of the Inflammasome in Neonatal Sepsis. National Institute of General Medical Sciences Grant K08 GM106143-03. James Wynn, PI; J. Hawiger, Mentor 2007- 2013 Intracellular Therapeutics for Inflammatory Liver Injury. National Institute of Alcohol Abuse and Alcoholism Grant 5 R01 AA 015752-05. J. Hawiger, PI 2008- 2013 Targeted Suppression of Cytokine Signaling in the Acute Phase Response. National Heart, Lung and Blood Institute Grant 5 R01 HL 085833-05. J. Hawiger, PI 2001- 2013 Superantigen-Induced Vascular Injury. National Heart, Lung and Blood Institute Grant 5 R01 HL 085833-10

J. Hawiger, PI

7

2001- 2011 Cellular and Molecular Microbiology Training Program. National Institute of Allergy and Infectious Diseases Grant 5 T32 AI 007611-10. J. Hawiger, PI

Major Committee Assignments: Vanderbilt University Medical School: 1975-1977 Transfusion Committee 1975-1976 Hemophilia Foundation (Cumberland Chapter) Advisory Board 1976-1978 Clinical Research Center Advisory Committee 1975-1978 Ph.D. Continuing Committee 1980-1982 Ph.D. Continuing Committee 1981-1982 Search Committee for Chairperson of Physiology Department 1991-1998 Academic Programs Committee 1996-1997 Co-chair, Task Force for Graduate and Postgraduate Education Strategic Plan for Vanderbilt University Medical Center 1998 Co-chair, Task Force for Faculty Compensation and Incentivization in Education 1999-2001 Committee for New Departments in the School of Medicine 1999-2004 Committee for Faculty Research Reward Plan 2001-2004 Strategic Academic Planning Group in the Medical Center 2002-2005 University Senate (elected) Boston VA Medical Center: 1978-1979 Research and Development Committee New England Deaconess Hospital:

1983-1989 Institutional Review Board on Human Studies Brigham & Women's Hospital: 1987-1990 Scientific Advisory Committee,General Clinical Research Center

Harvard Medical School:

1986-1987 Search Committee for Fikes Professorship 1987-1990 Standing Committee on Promotions, Reappointments, and Appointments 1988-1990 Standing Committee on Faculty Fellowships

The Commonwealth Fund/Bristol-Myers Squibb National Medical Fellowships in Academic Medicine for Minority Students:

1983-2005 National Advisory Committee Member

8

The American Red Cross (Bethesda MD):

1990-1995 Scientific Council Member

Memberships, Offices and Committee Assignments in Professional Societies: 1969- American Association for the Advancement of Science 1969- American Society for Microbiology 1970- American Federation for Clinical Research 1971- 2010 Southern Society for Clinical Investigation 1971- Infectious Diseases Society of America 1972-1982 Tennessee Blood Club 1975- Thrombosis Council, American Heart Association 1975- International Society on Thrombosis and Haemostasis 1975- American Society of Hematology 1977- American Society for Clinical Investigation 1977-1980 Hemostasis Subcommittee, American Society of Hematology 1981-1985 American Association of Pathologists 1981- New York Academy of Sciences 1982- Association of American Physicians 1985- American Society for Biochemistry and Molecular Biology 1983-1989 Executive Committee, Council on Thrombosis, American Heart Association 1985-1987 Vice-Chairman, Council on Thrombosis, American Heart Association 1987-1989 Chairman, Council on Thrombosis, American Heart Association 1987-1988 Chairman, Scientific Subcommittee on Platelets, American Society of Hematology 1988-1994 Executive Council, International Society of Thrombosis and Hemostasis 1989-1990 Committee on Finance and Budget, American Society of Hematology 1995-1997 Council on Thrombosis, International Society and Federation of Cardiology and International Society on Thrombosis and Haemostasis 1995-1996 Chairman, Scientific Subcommittee on Thrombosis and Vascular Biology, American Society of Hematology NIH Assignments: 1975-1983 Consultant (ad hoc) to Program Project Committee B, Pathology Study

Section A, and the NHLBI Parent Committee for SCORs in Acute Respiratory Failure

1982 Member, Research Manpower Committee 1983-1987 and 1991-1994 Member, Hematology Study Section I

9

1992 Chairman, the NHLBI Parent Committee, Programs in Vascular Biology and

Medicine 1995-present Consultant (ad hoc) to Heart, Lung, and Blood Program Project Review

Committee, Clinical and Integrated Cardiovascular Sciences (CICS) Study Section, and Host Interactions with Bacterial Pathogens (HIBP) Study Sections, T32 Review Special Emphasis Panel

2003 Member, NHLBI Clinical Proteomics Working Group 2006 Member, the NHLBI Strategic Plan, Working Group 2009 Member, the NHLBI Working Group on Sickle Cell Disease: Inflammation,

Thrombosis, and Vascular Biology 2010 Chair, the NHLBI Working Group on Blood Systems Response to Sepsis Veterans Administration Assignments: 2012-present MERIT Review Panel for Immunology and Dermatology-A Other Organizations Assignments:

Reviewer for the National Science Foundation; Medical Research Council of Canada; Israel Science Foundation

10

Major Research Interests: Molecular basis of innate immunity and inflammation (microbial, autoimmune, and metabolic signals); Intracellular Delivery of Peptides and Proteins (Intracellular Immunotherapy); Thrombosis Editorial Assignments: 1989-1992 Editor of Volumes A and B on "Platelets: Receptors, Adhesion, Secretion" in METHODS IN ENZYMOLOGY Series 1983-1987 Editor of THROMBOSIS RESEARCH 1985 Co-Editor of "Interaction of Platelets with the Vessel Wall, "Clinical Physiology Series, American Physiological Society 1986 Guest Editor of "Symposia on Hemostasis and Thrombosis: Molecular

and Cellular Pathology" in HUMAN PATHOLOGY, February and March, 1987

1987-1992 Member of Editorial Board of BLOOD 1987-1992 Member of Editorial Board of the JOURNAL OF VASCULAR BIOLOGY

AND MEDICINE 1991-1995 Co-Editor of ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR

BIOLOGY Referee for Journals:

Cell; Science; Proceedings of the National Academy of Sciences; New England Journal of Medicine; Journal of Biological Chemistry; Biochemistry; Journal of Clinical Investigation; Circulation; Blood; Thrombosis Research; Journal of Laboratory and Clinical Medicine; Clinica Chimica Acta; Journal of Infectious Diseases; Infection and Immunity; Prostaglandins; Journal of the American Medical Association, Journal of Medicinal Chemistry.

Teaching Experience: 1969-1975 Lecturer in "Pathogenic Mechanisms of infectious Diseases" Course at Vanderbilt University Medical School 1972-1975 Lecturer in "Topics in Infectious Diseases" Course at Vanderbilt University Medical School

11

1975-1978 Lecturer in "Critical Care" Lecture Series for the House Staff, Attending Staff and Students, Vanderbilt University Medical School 1975-1978 Organized Teaching Conferences on "Bleeding and Clotting Disorders" at Vanderbilt University Medical School 1978-1979 Attending Physician, VA Medical Service, Boston, Massachusetts 1978-1979 Organized Teaching Conferences for Students (Tufts and Boston Universities) and House Staff on "Bleeding and Clotting Disorders" at Boston VA Medical Center 1979-1982 Lecturer in "Pathology Course" 2nd-year Medical Students at Vanderbilt University Medical School 1979-1982 Lecturer in "Patient Management Problems" for 4th-year Medical Students at Vanderbilt University Medical School 1980-1982 Lecturer in Postgraduate Course organized by the American College of Physicians on "Recent Advances in Internal Medicine" at Vanderbilt University Medical School. 1980-1982 Lecturer in Pathology Seminar Series for Graduate Students at Vanderbilt University

1980-1982 Lecturer in the Teaching Conferences on "Hemostatic and Thrombotic Problems" for the House Staff in Pathology, Vanderbilt University Hospital 1981-1982 Organized a Seminar Series in Hemostasis and Thrombosis for Faculty, Staff, Medical Students and Graduate Students at Vanderbilt University School of Medicine 1980-1982 Lecturer in Pathology Seminar Series for Graduate Students at Vanderbilt University 1984-1989 Instructor in Pathophysiology 7040, Harvard Medical School (Coordinator of Hemostasis Block) 1987-1989 Lecturer, Physiology 215, Harvard Medical School 1987-1989 Lecturer, Pathology 205, Harvard Medical School 1988-1989 Lecturer,Critical Care Course,Tufts University School of Medicine

12

1991-1997 Director and Lecturer, Microbiology and Immunology Course for first year Medical Students at Vanderbilt University 1992-1994 Lecturer, Core Course on Bioregulation, Interdisciplinary Graduate Program, Vanderbilt University School of Medicine 1996-2003 Lecturer, Foundations in Microbiology and Immunology Course for Graduate Students, Vanderbilt University School of Medicine 1994-2011 Lecturer, Molecular and Cellular Immunology Course for Graduate Students, Vanderbilt University School of Medicine 1998-2011 Lecturer, Microbiology and Immunology Course for first year Medical Students at Vanderbilt University School of Medicine 1999-2011 Director, Cellular and Molecular Microbiology Training Program supported by the National Institute of Allergy and Infectious Diseases 2001-2002 Director and Lecturer, Cellular Microbiology of the Pathogen Host Interaction Course for Graduate Students, Vanderbilt University School of Medicine 2002-2010 Lecturer, Cellular Microbiology of the Pathogen-Host Interaction Course for Graduate Students, Vanderbilt University School of Medicine 2002-present Director, Immunobiology of Blood and Vascular Systems Training Program supported by the National Heart, Lung, and Blood Institute Publications: 1. Hanicki, Z., Hawiger, J., Hirszel, P., Twardowski, Z.: On some aspects of the antibody deficiency syndrome. Acta. Med. Pol. 1963, 4:229-241. 2. Hanicki, Z., Hawiger, J., Struzik, T.: Das Antikorpermangelsyndrom und die Mucoviscidosis. Wiener Klin. Wschr. 1963, 75:862-863. 3. Hawiger, J., Hanicki, Z., Struzik, T.: On the immunologic nature of antithrombin in

the course of lupus erythematosus disseminatus. Acta Med. Pol. 1964, 5:53-60. 4. Struzik, T., Hanicki, Z., Hawiger, J., Biernacka, B.: Cryocoagulopathy with presence of immunoantithrombin in the course of lupus erythematosus disseminatus. Acta Med. Pol. 1964, 5:61-66.

13

5. Hanicka, M., Hanicki, A., Hawiger, J., and Bernasowska-Knapczykowa, K.: On the appearance of the antibody deficiency syndrome in women. Polski Tygodnik Lekarski (Warsaw). 1965, 4:474-479.

6. Bobr, J., and Hawiger, J.: Characteristics of the hospital environment and the

population concerning the newborn infection study. Polski Tygodnik Lekarski (Warsaw). 1966, 21:281-285.

7. Bobr, J., Hawiger, J., and Jeljaszewicz, J.: Incidence and type of newborn infections

in hospitals. Polski Tygodnik Lekarski (Warsaw). 1966, 21:297-301. 8. Bobr, J., and Hawiger, J.: Postoperative wound infection in hospitals of the Krakow

region. Polski Tygodnik Lekarski (Warsaw). 1966, 21:1756-1760. 9. Jeljaszewicz, J., and Hawiger, J.: The resistance to antibiotics of strains of

Staphylococcus aureus isolated in Poland. Bull. Wld. Hlth. Org. 1966, 35:231-241. 10. Jeljaszewicz, J., and Hawiger, J.: The resistance to antibiotics of strains of

Streptococcus viridans, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Proteus, and Klebsiella isolated in Poland. Bull. Wld. Hlth. Org. 1966, 35:243-246.

11. Collective Report: Comparison of antibiotic-resistance of strains of Staphylococcus

aureus isolated in Poland in 1960, 1963, and 1964. Epidemiological Review (Warsaw). 1967, 21:183-191.

12. Collective Report: Comparison of antibiotic-resistance of strains of Streptococcus

viridans, Streptococcus faecalis, Klebsiella, Proteus, Escherichia coli, and Pseudomonas aeruginosa isolated in Poland in 1960, 1963, and 1964. Epidemiological Review (Warsaw). 1967, 21:193-197.

13. Hawiger, J., and Jeljaszewicz, J.: Sensitivity of Staphylococcus aureus to lysostaphin

cephalothin, benzyl penicillin, and semi-synthetic penicillins. Proceedings to the Fifth International Congress of Chemotherapy. Vienna. 1967, pp. 35-37.

14. Hawiger, J., and Jeljaszewicz, J.: Treatment with antibiotics: mistakes and

proposals. Polski Tygodnik Lekarski (Warsaw). 1967, 22:839. 15. Hawiger, J., and Jeljaszewicz, J.: Antibiotic sensitivity of Micrococcus radiodurans.

Appl. Microbiol. 1967, 15:304-306. 16. Lipinski, B., Hawiger, J., Jeljaszewicz, J.: Staphylococcal clumping with soluble fibrin

monomer complexes. J. Exp. Med. 1967, 126:979-988. 17. Hawiger, J.: The frequency of staphylococcal lysozyme production tested by plate

method. J. Clin. Pathol. 1968, 21:390-393.

14

18. Hawiger, J.: Purification and properties of lysozyme produced by Staphylococcus

aureus. J. Bacteriol. 1968, 95:376-384. 19. Hawiger, J.: Synthesis and lysis of staphylococcal cell wall: a review. Postepy

Hygieny I Medycyny Doswiadczalnej (Warsaw). 1968, 22:223-261. 20. Zak, C., Hawiger, J., and Jeljaszewicz, J.: Sensitivity of Staphylococcus aureus to 30

antibiotics. Chemotherapy. 1969, 14:7-21. 21. Hawiger, J., Collins, R.D., Horn, R.G. and Koenig, M.G.: Interaction of artificial

phospholipid membranes with isolated polymorphonuclear leukocytic granules. Nature (Lond.). 1969, 222:276-278.

22. Hawiger, J., Horn, R.G., Koenig, M.G., and Collins, R.D.: Activation and release of lysosomal enzymes from isolated leukocytic granules by liposomes. A proposed

model for degranulation in polymorphonuclear leukocytes. Yale J. Biol. Med. 1969, 42:57-70.

23. Hawiger, J., Collins, R.D., and Horn, R.G.: Precipitation of soluble fibrin monomer

complexes by lysosomal fraction of polymorphonuclear leukocytes. Proc. Soc. Exp. Biol. Med. 1969, 131:349-353.

24. Horn, R.G., Hawiger, J., and Collins, R.D.: Electron microscopy of fibrin-like

precipitate formed during the paracoagulation reaction between soluble fibrin monomer complexes and protamine sulfate. Br. J. Haematol. 1969, 17:463-466.

25. Hawiger, J., Niewiarowski, S., Gurewich, V., and Thomas, D.P.: Measurement of

fibrinogen and fibrin degradation products in serum by staphylococcal clumping test. J. Lab. Clin. Med. 1970, 75:93-108.

26. Hawiger, J., Hawiger, A., and Koenig, M.G.: Staphylococcal clumping and fibrinogen

and fibrin degradation products in inflammatory exudate. Proc. Soc. Exp. Biol. Med. 197l, 136:132-136.

27. Hawiger, J., Hawiger, A., and Koenig, M.G.: Activation of lysosomal enzymes in

polymorphonuclear leukocytic granules: the role of phospholipid-protein interaction. Yale J. Biol. Med. 1972, 45:42-48.

28. Hawiger, J., Marney, S.R. Jr., Colley, D.G., and Des Prez, R.M.: Complement-

dependent platelet injury by staphylococcal protein A. J. Exp. Med. 1972, 136:68-80. 29. Satterwhite, T.K., Hawiger, J., Burklow, S.L., and Koenig, M.G.: Degradation

products of fibrinogen and fibrin in bacteremia due to gram-negative rods. J. Infect. Dis. 1973, 127:437-44l.

15

30. Graybill, J.R., Hawiger, J., and Des Prez, R.M.: Complement and coagulation in

Rocky Mountain Spotted Fever. South. Med. J. 1973, 66:410-413. 31. Hawiger, J., and Timmons, S.: Dynamic changes in the membrane of leukocytic

lysosomes detected with fluorescent probe and accompanied by release of lysosomal enzymes. Biochem. Biophys. Res. Commun. 1973, 55:1278-1284.

32. Hawiger, J., and Wolff, S.M.: The Shwartzman Reaction. in Progress in Immunology

II. Clinical Aspects I. North Holland Publishing Company, Amsterdam, Oxford. 1974, 4:359- 362.

33. Des Prez, R.M., Bryan, C.S., Hawiger, J., and Colley, D.G.: The function of the

classical and alternate pathways of human complement in serum treated with EGTA and MgEGTA. Infect. Immun. 1975, 11:1235-1243.

34. Hawiger, J., Hawiger, A., and Timmons, S.: Endotoxin-sensitive membrane

component of human platelets. Nature (Lond.) 1975, 256:125-127. 35. Hawiger, J., Hammond, D.K., and Timmons, S.: Human fibrinogen possesses

binding site for staphylococci on Aα and Bβ polypeptide chains. Nature (Lond.) 1975, 258:643-645.

36. Niewiarowski, S., Lowery, C.T., Hawiger, J., Millman, M., and Timmons, S.:

Immunoassay of human platelet factor 4 (PF4, antiheparin factor) by radial immunodiffusion. J. Lab. Clin. Med. 1976, 87:720-733.

37. Hawiger, J.: Detection and comparison of fibrinogen and its derivatives in different

species by the staphylococcal clumping test. in Animal Models of Thrombobis and Hemorrhagic Diseases. U.S. Department of Health, Education, and Welfare, Washington, D.C., 1976, (NIH) 76-982, pp. 127-131.

38. Hawiger, J.: Disseminated intravascular coagulation induced by endotoxin: rabbit

model and man. in Animal Models of Thrombosis and Hemorrhagic Diseases. U.S. Department of Health, Education, and Welfare, Washington, D.C., 1976, (NIH) 76-982, pp. 49-54.

39. Hawiger, J.: Disseminated intravascular coagulation in patients with infections:

diagnostic and therapeutic approach. Mater. Med. Pol. 1976, 27:1-7. 40. Hawiger, J., Hawiger, A., Steckley, S., Timmons, S., and Cheng, C.: Membrane

changes in human platelets induced by lipopolysaccharide endotoxin. Brit. J. Haematol. 1977, 35:285-299. 41. Hawiger, J.: Immune injury to human platelets: the role of Fc fragment of IgG.

in The Proceedings of the Platelet Workshop, Philadelphia, Pennsylvania: 1976,

16

U.S. Government Printing Office. Washington, D.C., 1977. 42. Niewiarowski, S., Rucinski, B., Millman, M., and Hawiger, J.: Immunoassay of human

platelet factor 4 (antiheparin factor) and its significance for evaluation of the platelet function. in The Proceedings of the Platelet Workshop, Philadelphia, Pennsylvania, 1976, U.S. Government Printing Office. Washington, D.C., 1977.

43. Hawiger, J., Hammond, D.K., Timmons, S., and Budzynski, A.Z.: Interaction of

human fibrinogen with staphylococci: presence of a binding region on normal and abnormal fibrinogen variants and fibrinogen derivatives. Blood. 1978, 51:799-812.

44. Timmons, S., and Hawiger, J.: Separation of human platelets from plasma proteins

including Factor VIII VWF by a combined albumin gradient-gel filtration method using HEPES buffer. Thromb. Res. 1978, 12:297-306.

45. Hawiger, J.: Platelets in Sanarelli-Shwartzman Reaction and in Human Sepsis. in

Platelets: a multidisciplinary approach. G. de Gaetano and S. Garattini, Editors. Raven Press, New York, N.Y. 1978, 321-328.

46. Cheng, C.M., and Hawiger, J.: Affinity isolation and characterization of IgG Fc

fragment-binding glycoprotein from human blood platelets. J. Biol. Chem. 1979, 254:2165-2167.

47. Hawiger, J., Steckley, S., Hammond, D., Cheng, C., Timmons, S., Glick, A.D., and

Des Prez, R.M.: Staphylococci-induced human platelet injury mediated by Protein A and IgG Fc fragment receptor. J. Clin. Invest. 1979, 64:931-937.

48. Hawiger, J., Parkinson, S., and Timmons, S.: Prostacyclin inhibits mobilization of

fibrinogen-binding sites on human ADP- and thrombin-treated platelets. Nature (Lond.) 1980, 283:195-197.

49. Des Prez, R.M., Steckley, S., Stroud, R.M., and Hawiger, J.: Interaction of

Histoplasma capsulatum with human platelets. J. Infect. Dis. 1980, 142:32-39. 50. Schwartz, M.B., Hawiger, J., Timmons, S., and Friesinger, G.: Platelet aggregates in

ischemic heart disease. Thromb. Haemostas. 1980, 43:185-188. 51. Robertson, R.M., Robertson, D., Timmons, S., Friesinger, G., and Hawiger, J.:

Platelet aggregates in peripheral and coronary-sinus blood in patients with spontaneous coronary-artery spasm. Lancet. 1980, ii:829-831.

52. Hawiger, J.: Platelets, endothelium, and immune reactions in renal disease:

Introduction. in Hemostasis, Prostaglandins, and Renal Disease. G. Remuzzi, G. Mecca, and G. de Gaetano, Editors. Raven Press, New York, N.Y. 1980, 73-77.

53. Hawiger, J.: Platelets, endothelium, and immune reactions in renal disease:

17

Conclusion. in Hemostasis, Prostaglandins, and Renal Disease. G. Remuzzi, G. Mecca, and G. de Gaetano, Editors. Raven Press, New York, N.Y. 1980, 147-149.

54. Hawiger, J., Koenig, M.G.: Staphylococcal diseases. in The Science and Practice

of Clinical Medicine. J.P. Sanford, Editor, Grune and Stratton, 1981. 55. Hawiger, J., Timmons, S., Strong, D.D., Cottrell, B.A., Riley, M., and Doolittle, R.F.:

Identification of a region on human fibrinogen interacting with staphylococcal clumping factor. Biochemistry. 1982, 21:1407-1413.

56. Strong, D.D., Laudano, A.P., Hawiger, J., and Doolittle, R.F.: Isolation,

characterization, and synthesis of peptides from human fibrinogen that block the staphylococcal clumping reaction and construction of a synthetic clumping particle. Biochemistry. 1982, 21:1414-1420.

57. Hawiger, J., Timmons, S., Kloczewiak, M., Strong, D.D., and Doolittle, R.F.: Gamma

and alpha chains of human fibrinogen possess sites reactive with human platelet receptors. Proc. Natl. Acad. Sci. (USA). 1982, 79:2068-2071.

58. Fujimoto, T., Ohara, S., and Hawiger, J.: Thrombin-induced exposure and

prostacyclin inhibition of the receptor for Factor VIII/von Willebrand Factor on human platelets. J. Clin. Invest. 1982, 69:1212-1222.

59. Fujimoto, T. and Hawiger, J.: Adenosine diphosphate induces binding of von

Willebrand Factor to human platelets. Nature (Lond.) 1982, 297:154-156. 60. Kloczewiak, M., Timmons, S., and Hawiger, J.: Localization of a site interacting with

human platelet receptor on carboxy-terminal segment of human fibrinogen gamma chain. Biochem. Biophys. Res. Commun. 1982, 107:181-187.

61. Graber, S.E. and Hawiger, J.: Evidence that changes in platelet cAMP levels

regulate the fibrinogen receptor on human platelets. J. Biol. Chem. 1982, 257:14606-14609.

62. Kloczewiak, M., Timmons, S., and Hawiger, J.: Recognition site for the platelet

receptor is present on the 15-residue carboxy-terminal fragment of the gamma chain of human fibrinogen and is not involved in the fibrin polymerization reaction. Thromb. Res. 1983, 29:249-255.

63. Hawiger, J., Kloczewiak, M., Timmons, S., Strong, D., and Doolittle, R.F.: Interaction

of fibrinogen with staphylococcal clumping factor and with platelets. in Molecular Biology of Fibrinogen and Fibrin. R.F. Doolittle, M.W. Mosesson, Editors. Ann. N. Y. Acad. Sci. 1983, 521-535.

64. FitzGerald, G.A., Oates, J., Hawiger, J., Maas, R., Roberts, L.J. II, Lawson, J., and

Brash, A.: Endogenous biosynthesis of prostacyclin and thromboxane and platelet

18

function during chronic administration of aspirin in man. J. Clin. Invest. 1983, 71:676-688.

65. Huddleston, C.B., Lupinetti, F.M., Laws, K.H., Collins, J.C., Clanton, J.A., Hawiger,

J.J., Oates, J.A., and Hammon, J.W., Jr.: The effects of RO-22-4679, a thromboxane synthetase inhibitor, on ventricular fibrillation induced by coronary artery occlusion in conscious dogs. Circ. Res. 1983, 52:608-613.

66. Kloczewiak, M., Timmons, S., Lukas, T., and Hawiger, J.: Platelet receptor

recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the gamma chain. Biochemistry. 1984, 23:1767-1774.

67. Nachman, R.L., Leung, L.L.K., Kloczewiak, M., and Hawiger, J.: Complex formation

of platelet membrane glycoproteins IIb and IIIa with the fibrinogen D domain. J. Biol. Chem., 1984, 259:8584-8588. 68. Timmons, S., Kloczewiak, M., and Hawiger, J.: ADP-dependent common receptor

mechanism for binding of von Willebrand Factor and fibrinogen to human platelets. Proc. Natl. Acad. Sci. (USA), 1984, 81:4935-4939.

69. Sakon, M., and Hawiger, J.: Mechanism triggering platelet hemostatic plug formation

in vivo. Trans. Assoc. Am. Physicians, 1984, 97:311-318. 70. Hawiger, J., Kloczewiak, M., and Timmons, S.: Platelet receptor mechanisms for

adhesive macromolecules. in Interaction of Platelets with the Vessel Wall, J. Oates, J. Hawiger, and R. Ross, Editors. Clinical Physiology Series, American Physiological Society, 1985, 1-19.

71. Hawiger, J., Graber, S., and Timmons, S.: Prostacyclin regulation of platelet

receptors for adhesive macromolecules. in Interaction of Platelets with the Vessel Wall, J. Oates, J. Hawiger, and R. Ross, Editors. Clinical Physiology Series, American Physiological Society, 1985, 89-102.

72. Hawiger, J., Kloczewiak, M., Timmons, S., and Lukas, T.J.: Structural

characterization of the recognition site for platelet receptors on human fibrinogen. in Fibrinogen and Its Degradation Products, A. Henschen, Editor. Walter de Gruyter Inc., Berlin and New York, 1985, 345-368.

73. McManama, G., Lindon, J.N., Kloczewiak, M., Smith, M.S., Ware, J.A., Hawiger, J.,

Merrill, E.W., and Salzman, E.W.: Platelet aggregation by fibrinogen polymers crosslinked across the E domain. Blood. 1986, 68:363-371.

74. Timmons, S., Huzoor-Akbar, Grabarek, J., Kloczewiak, M., and Hawiger, J.:

Mechanism of human platelet activation by endotoxic glycolipids-bearing mutant

19

Re595 of Salmonella minnesota. Blood. 1986, 68:1015-1023. 75. Timmons, S., and Hawiger, J.: von Willebrand Factor can substitute for plasma

fibrinogen in ADP-induced platelet aggregation. Trans. Assoc. Am. Physicians. 1986, 99:226-235.

76. Hawiger, J.: Binding of von Willebrand Factor to platelets: Two receptor pathways. in

Factor VIII/von Willebrand Factor. Biological and Clinical Advances. N. Ciavarella, Z.M. Ruggeri, and T.S. Zimmerman. Editors. Wichtig Editors, Milan, 1986, 5-11.

77. Kloczewiak, M., Timmons, S., and Hawiger, J.: Reactivity of chemically cross-linked

fibrinogen and its fragments D toward the staphylococcal clumping receptor. Biochemistry. 1987, 26:6152-6156.

78. Hawiger, J.: Formation and regulation of platelet and fibrin hemostatic plug. in

Symposium on "Hemostasis: Molecular and Cellular Pathology" J. Hawiger, Guest Editor. Human Pathology, 1987, 18:111-122.

79. Hawiger, J.: Platelet receptor mechanisms for von Willebrand Factor. in Platelet

Activation. H. Yamazaki, Editor. Academic Press, Tokyo, 1987, 121-134. 80. Hawiger, J.: Adhesive interactions of blood cells and the vessel wall. in Hemostasis

and Thrombosis. Basic Principles and Clinical Practice, 2nd Edition. R. Colman, J. Hirsh, V. Marder, and E. Salzman, Editors. J.B. Lippincott Company, Philadelphia and Toronto, 1987, 182-209.

81. Hawiger, J., Steer, M., and Salzman, E.: Intracellular regulatory processes in

platelets. in Hemostasis and Thrombosis. Basic Principles and Clinical Practice, 2nd Edition. R. Colman, J. Hirsh, V. Marder, and E. Salzman, Editors. J.B. Lippincott Company, Philadelphia and Toronto, 1987, 710-725.

82. Hawiger, J.: Macromolecules that link platelets following vessel wall injury. Ann.

N.Y. Acad. Sci. 1987, 509:131-141. 83. Hawiger, J.: Hemostasis, bleeding, and thromboembolic complications of trauma and

infection. in Trauma, Sepsis, and Shock: the Physiological Basis of Therapy. G.H.A. Clowes Jr., Editor. Marcel Dekker, New York, 1987, 123-159.

84. Grabarek, J., Timmons, S., and Hawiger, J.: Modulation of human platelet protein

kinase C by endotoxic lipid A. J. Clin. Invest. 1988, 82:964-971. 85. Weiss, H.J., Hawiger, J., Ruggeri, Z.M., Turitto, V.T., Thiagarajan, P., and Hoffman,

T.: Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate. J. Clin. Invest. 1989, 83:288-297.

20

86. Hawiger, J., Kloczewiak, M., Bednarek, M., and Timmons, S.: Platelet receptor

recognition domain on alpha chain of human fibrinogen: Structure-function analysis. Biochemistry. 1989, 28:2909-2914.

87. Kloczewiak, M., Timmons, S., Bednarek, M., Sakon, M., and Hawiger, J.: Platelet

receptor recognition domain on the gamma chain of human fibrinogen and its synthetic peptide analogs. Biochemistry. 1989, 28:2915-2919.

88. Timmons, S., Bednarek, M., Kloczewiak, M., and Hawiger, J.: Anti-platelet "hybrid"

peptides analogous to receptor recognition domains on gamma and alpha chains of human fibrinogen. Biochemistry. 1989, 28:2919-2923.

89. Timmons, S., and Hawiger, J.: Isolation of human platelets from plasma by albumin

gradient and gel filtration. in Methods in Enzymology, J. Hawiger, Editor, Academic Press, 1989, 169:11-2l.

90. Hawiger, J.: Platelet secretary pathways: An overview. In Methods in

Enzymology, J. Hawiger, Editor, Academic Press, 1989, 169:191-195. 91. Bauer, K.A., Kass, B.L., ten Cate, H., Bednarek, M.A., Hawiger, J., and Rosenberg,

R.D.: Detection of Factor X activation in humans. Blood. 1989, 74:2007-2015. 92. Donaldson, D.J., Mahan, J.T., Amrani, D., and Hawiger, J.: Fibrinogen-mediated

epidermal cell migration: Structural correlates for fibrinogen function. J. Cell Sci. 1989, 94:101-108.

93. Romano, M., and Hawiger, J.: Interaction of endotoxic lipid A and lipid X with purified

human platelet protein kinase C. J. Biol. Chem. 1990, 265:1765. 94. Johnson, R.S., Her, G.R., Grabarek, J., Hawiger, J., and Reinhold, V.N.: Structural

characterization of monophosphoryl lipid A homologs obtained from Salmonella minnesota Re595 lipopolysaccharide. J. Biol. Chem. 1990, 265:8108.

95. Grabarek, J., Her, G.R., Reinhold, V.N., and Hawiger, J.: Endotoxic lipid A interaction

with human platelets: Structure-function analysis of lipid A homologs obtained from Salmonella minnesota Re595 lipopolysaccharide. J. Biol. Chem. 1990, 265:8117.

96. Shiba, E., Lindon, J.N., Kushner, L., Matsueda, G.R., Hawiger, J., Kloczewiak, M.,

Kudryk, B., and Salzman, E.W.: Antibody-detectable changes in fibrinogen adsorption affecting platelet activation on polymer surfaces. Am. J. Physiol. 1990, 260:(Cell Physiology) C965-C974.

97. Bauer, K.A., Kass, B.L., ten Cate, H., Hawiger, J., and Rosenberg, R.D.: Factor IX is

activated by the tissue factor mechanisms in the human circulation. Blood. 1990, 76:731-736.

21

98. Hawiger, J.:Platelet vessel wall interactions-platelet adhesion and aggregation.

Atherosclerosis Reviews. 1990, 21:165:186. 99. Chen, C.S., and Hawiger, J.: Reactivity of synthetic peptide analogs of adhesive

proteins in regard to the interaction of human endothelial cells with extracellular matrix. Blood, 1991, 77:2200-2206.

100. Hawiger, J: Blood-vascular wall interface in thrombosis and rethrombosis. in

Thrombolysis. E. Haber, and E. Brunwald, Editors, Mosley Year Book, 1991, 133-153.

101. Hawiger, J.: Adhesive interactions of platelets and their blockade. Annals of the

New York Academy of Sciences. 1991, 614:270-278. 102. Blumenstein, M., Matsueda, G.R., Timmons, S., and Hawiger, J.: A β -turn is

present in the 392-411 segment of the human fibrinogen γ-chain. Effects of structural changes in this segment on affinity to antibody 4A5. Biochemistry. 1992, 31:10692-10698.

103. Hawiger, J.: Physiology of hemostasis: The vascular wall. in Hematology of

Infancy and Childhood, 4th edition. D.G. Nathan, and F.A. Oski, Editors. W.B. Saunders Company, 1992.

104. Hawiger, J., and Handin, R.I.: Physiology of hemostasis: The platelet. in

Hematology of Infancy and Childhood, 4th edition. D.G. Nathan, and F.A. Oski, Editors. W.B. Saunders Company, 1992.

105. Hawiger, J.: Introduction to platelet structural and functional organization. in

Methods in Enzymology. J. Hawiger, Editor. Academic Press, 1992, 215:3-5. 106. Hawiger, J.: Repertoire of platelet receptors. in Methods in Enzymology. J.

Hawiger, Editor. Academic Press, 1992, 215:131-136.

107. Hawiger, J., and Timmons, S.: Binding of fibrinogen and von Willebrand Factor to platelet glycoprotein IIb-IIIa complex. in Methods in Enzymology. J. Hawiger, Editor. Academic Press, 1992, 215:228-243.

108. Hawiger, J.: The interaction of platelets and other cellular elements with the vessel wall. in Vascular Medicine. J. Loscalzo, M.A. Creager, and V.J. Dzau, Editors. Little, Brown and Company, 1992, 205-231.

109. Cordle, S.R., Donald, R., Read, M.A., and Hawiger, J.: Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-rel and related NF-κB proteins in human monocytic THP-1 cells. J. Biol. Chem. 1993, 268:11803-11810.

110. Read, M.A., Cordle, S.R., Veach, R.A., Carlisle, C.D., and Hawiger, J.: Cell-free pool

22

of CD14 mediates activation of NF-kB by lipopolysaccharide in human endothelial cells. Proc. Natl. Acad. Sci. (USA). 1993, 90:9887-9891.

111. Hawiger, J., Brass, L.F., and Salzman, E.W.: Signal transduction and intracellular regulatory processes in platelets. in Hemostasis and Thrombosis. Basic Principles and Clinical Practice, 3rd edition. R.W. Colman, J. Hirsh, V.J. Marder, and E.W. Salzman, Editors. J.B. Lippincott Company, 1994, 603-628.

112. Hawiger, J.: Adhesive interactions of blood cells and the vascular wall. in Hemostasis and Thrombosis. Basic Principles and Clinical Practice, 3rd edition. R.W. Colman, J.Hirsh, V.J. Marder, and E.W. Salzman, Editors. J.B. Lippincott Company, 1994, 762-796.

113. Hawiger, J.: Lipopolysaccharide-induced signal transduction and gene transcription.

in Endotoxin and the Lungs; K. Brigham, Editor. 1994, 69-82. 114. Donahue, J., Patel, H., Anderson, W.F., and Hawiger, J.: Three-dimensional

structure of the platelet integrin recognition segment of the fibrinogen γ chain obtained by carrier protein-driven crystallization. Proc. Natl. Acad. Sci. (USA). 1994, 91:12178-12182.

115. Donahue, J.P., Sugg, N., Hawiger, J.: The Integrin αv Gene: Identification and

Characterization of the Promoter Region. Biochemica Biophysica Acta, 1994, 1219:228-232.

116. Hawiger, J.: Adhesive ends of fibrinogen and its antiadhesive peptides: The end of a

saga? in Seminars in Hematology; Festschrift For Marjorie Zucker. S. Karpatkin, Editor. 1995, 32:99-109.

117. Hawiger J. Mechanisms Involved in Platelet Vessel Wall Interaction. Thrombosis

and Haemostasis. 1995, 74 (1): 369-372. 118. Donald, R., Ballard, D., and Hawiger, J.: Proteolytic Processing of NF-κB/IκB in

Human Monocytes: ATP-Dependent Induction by Pro-Inflammatory Mediators. J. Biol. Chem. 1995, 270:9-12.

119. Lin, Y.-Z., Yao, S.Y., Veach, R.A., Torgerson, T.R., and Hawiger, J.: Inhibition of

Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-Permeable Motif and Nuclear Localization Sequence. J. Biol. Chem. 1995, 270:14255-14258.

120. Hawiger, J.: Platelets in Thrombosis and Rethrombosis.in Scientific American

Molecular Cardiovascular Medicine. (Ed. Haber, E.), Scientific American, Inc. New York, NY, 1995, 157-175.

121. Lin, Y-Z, Yao, S-Y, Veach, R.A., Hawiger, J.: A Novel Method for Delivering

Synthetic Peptides into Living Cells to Regulate Intracellular Signal Transduction. in

23

Peptides: Chemistry, Structure, and Biology (Eds. Pravin T.P. Kaumaya and R.S. Hodges) Mayflower Scientific Ltd., 1995, 160-162.

122. Liu, X.-Y., Timmons, S., Lin, Y.-Z., and Hawiger, J.: Identification of a Functionally

Important Sequence in the Cytoplasmic Tail of Integrin β3 Using Cell-Permeable Peptide Analogs. Proc. Natl. Acad. Sci. (USA), 1996, 11819-11824.

123. Lin, Y-Z, Yao, S.-Y., and Hawiger, J.: Role of Nuclear Localization Sequence in

Fibroblast Growth Factor-1-stimulated Mitogenic Pathways. J Biol. Chem. 1996, 271:5305-5308.

124. Hawiger, J.: Cellular Import of Functional Peptides to Block Intracellular Signaling.

Current Opinion in Immunology. 1997, 9:189-196. 125. Zhang, L., Torgerson, T.R., Liu, X.-Y., Timmons, S., Colosia, A.D., Hawiger, J., and

Tam, J.P.: Preparation of Functionally Active Cell-Permeable Peptides by Single-Step Ligation of Two Peptide Modules. Proc. Natl. Acad. Sci. (USA) 1998, 95:9184-9189.

126. Chu, Z.-L., Didonato, J.A., Hawiger, J., and Ballard, D.W.: The Tax Oncoprotein of

Human T-Cell Leukemia Virus Type 1 Associates With and Persistently Activates IκB kinases Containing IKKα and IKKβ. J. Biol. Chem. 1998, 273:15891-15894.

127. Torgerson, T.R., Colosia, A.D.., Donahue, J.P., Lin, Y.-Z., and Hawiger, J.:

Regulation of NF-κB, AP-1, NFAT, and STAT1 Nuclear Import in T Lymphocytes by Noninvasive Delivery of Peptide Carrying the Nuclear Localization Sequence of NF-κB p50. J. Immunol. 1998, 161:6084-6092.

128. Ware, K.S., Donahue, J.P., Hawiger, J., and Anderson, W.F.: Structure of the

Fibrinogen γ Chain Integrin Binding and Factor XIIIa Crosslinking Sites Obtained Through Carrier Protein Driven Crystallization. Protein Science. 1999, 8:2663-2671.

129. Hawiger, J.: Noninvasive Intracellular Delivery of Functional Peptides and Proteins.

Current Opinion in Chemical Biology. 1999, 3:89-94. 130. Hawiger, J., Veach, R.A., Liu, X.-Y., Timmons, S., and Ballard, D.W.: IκB Kinase

Complex is an Intracellular Target for Endotoxic Lipopolysaccharide in Human Monocytic Cells. Blood. 1999, 94:1711-1716.

131. Liu, X.Y., Robinson, D., Veach, R.A., Liu, D., Timmons, S., Collins, R.D., and

Hawiger, J.: Peptide-Directed Suppression of a Pro-inflammatory Cytokine Response. J. Biol. Chem. 2000, 275:16774.

132. Hawiger, J.: Adhesive Interactions of Blood cells and the Vascular Wall in

Hemostasis and Thrombosis in Hemostasis and Thrombosis Basic Principals & Clinical Practice, 4th Edition, Lippincott Williams & Wilkins, Philadelphia, 2001.

24

133. Oltz, E.M., Hawiger, J.: Immunology at Vanderbilt University. Immunol. Res. 2001,

23(2-3):97-98. 134. Hawiger, J.: Innate Immunity and Inflammation: A Transcriptional Paradigm.

Immunol. Res. 2001, 23(2-3):99-109. 135. Hawiger J.: Peptide/Protein Delivery in Encyclopedia of Molecular Medicine, John

Wiley and Sons, 2001, 2435-2438. 136. Hawiger, J. A.: Stand-Off Between rhAPC and LPS in Healthy Human Subjects.

Blood 2003, 102(6):1940-1941. 137. Veach, R.A., Liu, D., Yao, S., Chen, Y., Liu, X.Y., Downs, S., and Hawiger, J.:

Receptor/Transporter-Independent Targeting of Functional Peptides Across the Plasma Membrane. J. Biol. Chem. 2004, Mar 19; 279(12):11425-31.

138. Liu, D, Liu, X.Y., Robinson, D., Burnett, C., Jackson, C., Seele, L., Veach, R.A.,

Downs, S., Collins, R.D., Ballard, D.W., and Hawiger, J.: Suppression of Staphylococcal Enterotoxin B-Induced Toxicity by a Nuclear Import Inhibitor. J. Biol. Chem. 2004, Apr 30; 279(18):19239- 46.

139. Liu, D., Li, C., Chen, Y., Burnett, C., Liu, X.Y., Downs, S., Collins, R.D., and Hawiger,

J.: Nuclear Import of Proinflammatory Transcription Factors Is Required for Massive Liver Apoptosis Induced by Bacterial Lipopolysaccharide. J. Biol. Chem. 2004, Nov 12; 279(46):48434-42.

140. Li, C., Zienkiewicz, J., and Hawiger, J.: Interactive Sites in the MyD88 Toll/Interleukin

(IL) 1 Receptor Domain Responsible for Coupling to the IL1β Signaling Pathway. J. Biol. Chem. 2005, July 15; 280(28):26152-9.

141. Jo, D., Liu, D., Yao, S., Collins, R.D., and Hawiger, J.: Intracellular Protein Therapy

with SOCS3 Inhibits Inflammation and Apoptosis. Nature Medicine. 2005, Aug; 11(8):892-8. (Comment on: in Research Highlights Nature Biotechnology 23, 949 (2005)

142. Bezbradica, JS, Gordy, LE, Hill, T, Dragovic, S, Stanic, AK, Hawiger, JJ, Unutmaz,

D, Van Kaer, L, Joyce, S: Granulocyte-macrophage colony stimulating factor deficiency results in the development of natural T (iNKT) cells with defective cytokine secretion. Immunity. 2006, Sep; 25(3):487-497 (Comment on: Immunity, 2006, Sep; 25(3): 393-5). (Recommended by the Faculty of 1000)

143. Zanchi C, Zoja C, Morigi M, Valsecchi F, Liu XY, Rottoli D, Locatelli M, Buelli S,

Pezzotta A, Mapelli P, Geelen J, Remuzzi G, Hawiger J: Fractalkine and CX3CR1 Mediate Leukocyte Capture by Endothelium in Response to Shiga Toxin 2. J. Immunol. 2008, Jul 15; 181(2):1460-9.

25

144. Liu D, Zienkiewicz J, DiGiandomenico A, Hawiger J: Suppression of Acute Lung

Inflammation by Intracellular Peptide Delivery of a Nuclear Import Inhibitor. Molecular Therapy. 2009, May; 17(5):796-802. 2009, Mar 3; [Epub ahead of print].

145. DiGiandomenico A, Wylezinski LS, Hawiger J: Intracellular delivery of a cell-penetrating SOCS1 that targets IFN-gamma signaling. Science Signaling. 2009, Jul 21; 2(80):ra37.

146. Fletcher TC, DiGiandomenico A, Hawiger J: Extended anti-inflammatory action of a degradation-resistant mutant of cell-penetrating suppressor of cytokine signaling 3. J Biol Chem. 2010, Jun 11; 285(24):18727-36. Epub 2010 Apr 16.

147. Moore DJ, Zienkiewicz J, Kendall PL, Liu D, Liu X, Veach RA, Collins RD, Hawiger J: In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes. PLoS ONE 2010, Oct 6;5(10):e13235. (Recommended by the Faculty of 1000)

148. Hawiger J, Musser JM: How to approach genome wars in sepsis? Critical Care 2011, 15:1007

149. Lin Q., Liu Y., Moore DJ, Elizer, S., Veach R.A., Hawiger J.,* and Ruley HE,*: Cutting edge: The “Death” Adaptor CRADD/RAIDD Targets BCL10 and Suppresses Agonist-Induced Cytokine Expression in T Lymphocytes. Journal of Immunology 2012. Feb 8 [Epub ahead of print]. *Corresponding authors

150. Veach RA, Zienkiewicz, Collins, RD, and Hawiger J.: Lethality in Pulmonary Anthrax is Reduced by Combining Nuclear Transport Modifier with Antimicrobial Therapy. PLoS ONE 2012, 7(1):e30527, Epub 2012/02/01. doi: 0.1371/journal.pone.0030527. PubMed PMID: 22291977; PubMed Central PMCID: PMC3266913.

151. Liu Y, Major AS, Zienkiewicz J, Gabriel CL, Veach RA, Moore DJ, Collins RD,

Hawiger J. Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver. J Am Heart Assoc. 2013; 2(2):e000093. Epub 2013/04/09. doi: 10.1161/JAHA.113.000093. PubMed PMID: 23563994; PubMed Central PMCID: PMC3647260

152. Sethman C, Hawiger J. The Innate Immunity Adaptor SARM Translocates to the Nucleus to Stabilize Lamins and Prevent DNA Fragmentation in Response to Pro-apoptotic Signaling PLos ONE. 2013; 8(7): e70994: doi: 10.1371/journal.pone.0070994

153. Zienkiewicz J, Armitage A, Hawiger J. Targeting nuclear transport shuttles, importins/karyopherins alpha by a Peptide Mimicking the NF kappa B1/p50 Nuclear Localization Sequence. J Am Heart Assoc. 2013; 2(5):e000386.

26

doi:10.1161/JAHA.113.000386.

154. Qiao H, Liu Y, Veach RA, Wylezinski L, Hawiger J. The Adaptor CRADD/RAIDD Controls Activation of Endothelial Cells by Proinflammatory Stimuli. J Biol Chem. 2014 Aug.8,289(32) 21973-83.doi:10.1074/jbc.M114.588723. Epub 2014 Jun 23. (Cover picture)

155. DiGiandomenico A*, Veach RA*, Zienkiewicz J*, Moore DJ, Wylezinski, LS, Hutchens, MA, Hawiger J. The “Genomic Storm” Induced by Bacterial Endotoxin is Calmed by a Nuclear Transport Modifier that Attenuates Localized and Systemic Inflammation. PLoS One 2014; 9(10):e110183. Doi:10.1371/journal pone.0110183 (*co-first authors)

156. Hawiger J., Veach RA, Zienkiewicz J. New Paradigms in Sepsis: From Prevention to Protection of Failing Microcirculation. J. Thromb. Haemost. 2015 Jul 18 doi: 10.1111/jth13061. (Epub ahead of print)

Books and Monographs: 1. Jeljaszewicz, J., Cybulska, J., Hawiger, J., and Zak, C.: Gram-Positive Cocci,

Biology, Identification and Diagnostic Procedures. Monographs of National Institute of Public Health, Warsaw, Poland, 1970.

2. Oates, J.A., Ross, R., and Hawiger, J.: Interaction of Platelets with the Vessel Wall.

Clinical Physiology Series, American Physiological Society, Waverly Press, Baltimore, 1985.

3. Hawiger, J.: (Volume Editor) "Platelets: Receptors, Adhesion, Secretion, Part A" Vol.

169, Colowick and Kaplan's "Methods in Enzymology" Series, Academic Press, New York, 1989.

4. Hawiger, J.: (Volume Editor) "Platelets: Receptors, Adhesion, Secretion, Part B" Vol.

215, Colowick and Kaplan's "Methods in Enzymology" Series, Academic Press, New York, 1992.