Auburn University MRI Research Auburn University MRI Research CenterCenter

Facility OverviewFacility Overview

●Three story – 45,000 SF building●MRI systems

■ 3 Tesla (T) open-bore whole body■ 7T whole body

●Designed to support research and clinical operations■ Animal facilities

Short-term holding facility Minimally-invasive procedures area

■ Training for faculty/staff/students

●Funded by a $21M State bond issued in 2007

Auburn University ObjectivesAuburn University Objectives

●Increase AU research funding■ Establish AU as a leader in MRI research■ Enhance AU’s reputation as a major research

university■ Attract businesses/industries to the AU

Research Park

●Provide additional healthcare capabilities for the region

AU MRI Research CenterAU MRI Research Center

●Partnership between■ Auburn University■ Siemens Healthcare■ East Alabama Medical Center■ Alabama Imaging Inc.■ University of Alabama at Birmingham (UAB)■ International

Central South University (China)Siemens Corporate Technology (China)

Auburn Research ParkAuburn Research Park

First FloorFirst Floor

Second FloorSecond Floor

AU Research

The Orthopaedic Clinic

USAARL

Third FloorThird Floor

Rehab Works – EAMC

AU Kinesiology

Auburn Neurosurgery

Proposed Operating ScenarioProposed Operating Scenario

●EAMC/AI controls 3T and clinical area■ 8 hours/day (8AM-4PM) Mon-Fri■ Lease at market value

●AU controls 3T■ 16 hours/day (4PM-8AM) Mon-Fri■ 24 hours/day Sat, Sun, holidays

●7T is research only■ AU control 24/7

TimelineTimeline●June ‘09 – Order equipment●July ‘09 – Building design●July ‘09 – Begin seminar series●Jan ‘10 – Begin construction●Summer ‘10 – Begin training●Sept ‘10 – Construction complete●Oct ‘10 – 3T/7T install●Oct ‘10 – Begin 3T operations●Spring ‘11 – Begin 7T operations

Current and Potential Current and Potential Research ProjectsResearch Projects

● Coil design & Manufacture■ Technology commercialization■ Wireless technology

● Orthopedic Injury/Rehab■ Auburn Athletics / Andrews Orthopedics

● fMRI/Cognitive Neuroscience■ Autism■ Psychology / Human Sciences

● Communication Disorders■ Audiology■ Speech Pathology

● Advanced cardiac imaging■ UAB collaboration (NIH)

● Fat Imaging■ Diabetes and obesity

● Metabolic/Molecular imaging■ MRS/MRSI■ Alzheimer’s disease (NIH)

3T Open-Bore MRI3T Open-Bore MRI

●FDA certified for clinical use

●70 cm bore

●173 cm length

3T Open-Bore MRI3T Open-Bore MRI

Standard ApplicationsStandard Applications

●Neurology

●Angiography

●Cardiac

●Body

●Oncology

●Orthopedic

●Pediactric

●Scientific

Spine Imaging at 3TSpine Imaging at 3T

●4-channel neck coil

●24-channel spine coil

Axially-Loaded Lumbar Spine Axially-Loaded Lumbar Spine MRIMRI

Advanced Applications - DESSAdvanced Applications - DESS

●Increased cartilage/fluid contrast

Advanced Neuro ApplicationsAdvanced Neuro Applications

●fMRI acquisition/analysis

●Diffusion

●Perfusion

●BOLD Imaging

●Advanced Functional Neuro

InVivo Esys fMRI SystemInVivo Esys fMRI System

7T MRI7T MRI

MAGNETOM UHF Community (22 sites):MAGNETOM UHF Community (22 sites):1. Massachusetts General Hospital, Boston, USA

Imaging since 08/2002

2. Institute for Neuro-Biology, Magdeburg, Germany

Imaging since 02/2005

3. New York University, NYC, USA

Imaging since 03/2005

4. Center for MR Research, Minneapolis, USA

Imaging with Siemens console since 12/2005

5. Gachon Medical School, Seoul, Korea

Imaging since 04/2006

6. Oregon Health, Portland, USA

First images 12/06

7. Erwin Hahn Institute for Magnetic Resonance, Essen, Germany Imaging since 09/2006

8. Center for Imaging in Biomedicine, Lausanne, Switzerland

Imaging since 11/2006

9. Max Plank Institute, Tübingen, Germany (9.4T)

Imaging since 07/2007

10. CEA, Paris, France

Imaging since 02/2007

11. CEA, Paris, France, 11.7T

to be installed 2013

12. UPMC, Pittsburgh, USA

former GE system converted to Siemens

Imaging since 05/2007

13. Max Plank Institute, Leipzig, Germany Imaging since 07/2007

14. Medical University of Vienna, Vienna, Austria

Imaging since 04/2008

15. DKFZ, Heidelberg, Germany

Imaging since 08/2008

16. Forschungszentrum Jülich, Germany (9.4T/900)

Imaging since

17. HUP, Philadelphia, PA, USA

Imaging since 06/2008

18. MDC, Berlin, Germany

Imaging since 12/2008

19. CAS, Beijing, China

To be installed in Fall 2009

20. Oxford University, Oxford, UK

To be installed in spring 2010

21. Auburn University, Auburn, Alabama, USA

To be installed Fall 2010

22. CMRR, Minneapolis, USA

To be installed in fall 2010

Other Siemens 7T Installations in USA

●MGH/ Harvard/ MIT

●NYU

●Penn

●Minnesota

●Portland, Oregon

●Pittsburgh

High-Field ImagingHigh-Field ImagingT2-weighted imaging of the human hippocampus

1.5T 7.0T

Functional MRI (fMRI)Functional MRI (fMRI)

Van der Zwaag, et al, Neuroimage. 2009 May 14

fMRI at 1.5T, 3.0T, 7.0TfMRI at 1.5T, 3.0T, 7.0T

Van der Zwaag, et al, Neuroimage. 2009 May 14

fMRI at 1.5T, 3.0T, 7.0TfMRI at 1.5T, 3.0T, 7.0T

7.0T 1.5T

Behr, et al, Skeletal Radiol. 2009 Sep;38(9):911-7

7.0T 1.5T

Behr, et al, Skeletal Radiol. 2009 Sep;38(9):911-7

Spatial ResolutionSpatial Resolution

3T 7T

fMRI BOLD 3.0 / 2.5 mm6 0.5 / 3.0 mm3

Brain0.5 / 1.0 mm7

1.0 / 1.0 mm7

0.05 / 2.0 mm4

0.7 / 0.7 mm5

Musculoskeletal 0.30 / 2.0 mm2 0.15 / 1.0 mm1

1. Regatte, et al, JMRI Vol.25, 2 Pages: 262-2692. Kuhl, et al, Radiology. 2008 Apr;247(1):16-353. Yacob, et al, Neuroimage. 2007 October 1; 37(4): 1161–

11774. Nakada, Brain and Development ,29 (6), July 2007, 325-3355. Thomas, et al, JMRI 2008 November; 28(5): 1266–12726. Miller, et al, J Neurophysiol 99:1969-1982, 20087. Wiggins, et al, Magn Reson Med, 56(1), 216-223, 2006

SpectroscopySpectroscopy

●Proton spectroscopy (3T and 7T)■ Single voxel■ Chemical shift imaging

●Multinuclear spectroscopy (7T only)■ 7Li, 13C, 17O, 19F, 23Na, 31P

MRI - CoilsMRI - Coils

Small Rodent MRISmall Rodent MRI

Small Animal MRISmall Animal MRI

Fat ImagingFat Imaging

Fat Detection & QuantificationFat Detection & Quantification