AU5800 hardware, features and comparisons to other AU models
Transcript of AU5800 hardware, features and comparisons to other AU models
Page 1 of 45Beckman Coulter Professional Development
AU5800 hardware, features and comparisons to other AU models
5800 Comparisons Rev. A (August 2014)
5800 Comparisons Rev. A (August 2014)
Table of Contents
Introduction……………………………………………………………………. 3
Terminology and Configuration……………………………………………… 5
Throughput…………………………………………………………………….. 6
New Hardware Features……………………………………………………... 9
Maintenance Improvements…………………………………………………. 18
Part Numbers………………………………………………………………….. 19
New ISE Features…………………………………………………………….. 20
New Software Features from AU480/AU680………………………………. 21
Software Changes……………………………………………………………. 30
New Software Features from AU2700/AU5400…………………………… 36
Page 2 of 45Beckman Coulter Professional Development
Introduction
AU5800 Overview:
• Describes the hardware, ISE, and software differences between the AU5800 and the AU480/AU680, and AU2700/AU5400
• Provides an overview of the AU5800 new features and benefits
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Integrated Data Workstation & Auto Repeat Unit• Less footprint• Improved workflow and results processing
New Style for AU5800
Newly Designed Covers and Body Style• Ergonomic design to improve everyday user tasks
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Terminology and Configuration
Units Single ISE Dual ISE» AU5810 AU5811 AU5812» AU5820 AU5821 AU5822» AU5830 AU5831 AU5832» AU5840 AU5841 AU5842
» Unit Configuration:– AAAA: A test is on unit 1, 2, 3, and 4
– ABCD: A test is only on unit 1, 2, 3, or 4
– AABB: Configuration is the most efficient (variance for low volume tests)
– Racks can bypass a unit for throughput based on test requisition and unit configuration
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Scalability and Throughput4 Scalable Models to Meet High and Ultra-high Volume Testing
AU5840: 8000 tests/hr, 9800 tests/hr with dual ISE
AU5830: 6000 tests/hr, 7800 tests/hr with dual ISE
AU5431: 4800 tests/hr, 6600 tests/hr with dual ISE
AU5820: 4000 tests/hr, 5800 tests/hr with dual ISE
AU5421: 3200 tests/hr, 5000 tests/hr with dual ISE
AU5810: 2000 tests/hr, 3800 tests/hr with dual ISE
AU2700: 1600 tests/hr, 2133 tests/hr with single ISE
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Enhanced Performance
Higher throughput• 2,000 photometric tests per hour
per analytical unit vs. 1,600 photometric tests per hour per analytical unit on the AU2700/AU5400:
25% increase over AU2700/AU5400
• 3.6 second cycle time vs. 4.5 second cycle time on the AU2700/AU5400
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Affects on Throughput
Inner/Outer Wheel Assignment• Parameters > Common Test
• Parameters > Test Name
Unit Assignment• Parameters > Common Test
• Parameters > Group of Tests
Requisitions• Individual tests vs. profiles
• Number of tests requisitioned per sample affects sample throughput
Operators• Move a test to a different unit for
troubleshooting
• Program a new test on system
Default profiles5800 Comparisons Rev. A (August 2014)
Page 8 of 45Beckman Coulter Professional Development
New Hardware Features
Rack Collection Trays (2): each holds 20 racks or 200 samples Rear
Return LanePrimary LaneBypass Lane
DualSample Probes
RackBuffer Unit: Auto Repeat
ISE
Rack Loading Trays (2): each holds 20 racks or 200 samples
R2: 54 positions
R1: 54 positions
Front
Priority Rack Loading Unit
5800 Comparisons Rev. A (August 2014) Page 9 of 45Beckman Coulter Professional Development
New Hardware FeaturesRack Trays
Rack Set Trays and Rack Collection Trays • Easy loading of up to 20 racks (200
samples) per tray
• Rack set unit accommodates two trays (400 total samples), and rack collection unit accommodates two trays (400 total samples)
• Trays can be removed from analyzer to transport racks
• All four trays are interchangeable
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New Hardware Features Priority Rack Loading Unit
Priority Rack Loading Unit• Load emergency racks (red) or routine
racks (white) on 2 priority loading positions and press Start
• Racks are moved from the rack buffer unit as a priority over racks loaded on the rack set trays, and processed on the bypass lane for faster turnaround time
If two racks are placed on the priority rack loading unit, the rack in position one is processed first.
• Priority for QC and Calibrator racks can be configured
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New Hardware Features Rack Buffer Unit / Auto Repeat
Rack Buffer Unit / Auto Repeat• A separate Auto Repeat unit is not
required. (AU5400 required a separate Auto Repeat unit)Less costLess space required
• Repeat racks are transferred to the bypass lane for priority repeat analysis.
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New Hardware FeaturesReagent Compartments
• Larger Capacity Reagent Compartments
AU5800: 54 reagent positions
AU2700/AU5400: 48 reagent positions per unit
• Cleaning solution bottles for contamination prevention are located outside of the R1 and R2 refrigerators for additional onboard reagent positions from AU2700/AU5400
R1: positions 57. CLN-1, 58. CLN-2, 59. CLN-1, and 60. CLN-2
R2: positions 55. CLN-1, 56. CLN-2, 57. CLN-1, and 58. CLN-2
• Diluent bottles are located by the R1 refrigerator.
R1: positions 55. Diluent/W2 and 56. Diluent/W2
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Programmable and Onboard Tests
Increased number of programmable tests:
AU5800: 120
AU5400: 99
AU2700: 99
Increased number of onboard assays:
AU5830 and AU5840: 120
AU5820: 111
AU5810: 57
AU5421 and AU5431: 99
AU2700: 51
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Reagent Bottles
• 15 mL, 30 mL and 60 mL bottle reagent empty/dead volume is the same as other AU systems:
15 mL 400 uL30 mL 1.0 mL60 mL 1.0 mL
• 120 mL and 180 mL bottles:
The current 120 and 180 mL (5400/2700) bottles can not be used on the AU5800 because bubbles and level detection errors are produced due to the rotation speed of the R1 and R2 compartments
The 180 mL bottles are re-designed for 5800, 5400 and 2700 and can be used following a software update (specific for 180 mL bottle usage) performed by BCI personnel
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Wash Solution
• The diluted wash solution is 1% +/- 0.5%.
• The total consumption of wash solution (concentrated) is approximately 130 mL per hour per unit.
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Inner/Outer Wheel and Odd/Even Components
AU5800 Odd (S1, R11, R21) = Inner wheel Even (S2, R12, R22) = Outer wheel
AU2700/AU5400 Odd (S1, R11, R21) = Outer wheel Even (S2, R12, R22) = Inner wheel
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Maintenance Improvements
AU2700/AU5400: If a cuvette fails the Weekly Photocal
(cuvette check), the entire 30 minuteprocedure must be repeated
No flag to alert operators a test was run on a defective cuvette
AU5800: If a cuvette fails the Weekly Photocal
(cuvette check), the individual cuvette can be re-checked in 8minutes. Significant operator and analyzer time savings
Photometer check included in the Photocal procedure: save approximately 5 minutes
A new “Wa” flag indicates a test was run on a cuvette that failed the photocal
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Part Numbers
AU5800:• Lamp: MU8550
• R probe: MU8581
• S probe: MU9934
• Spiral mix bar: MU8554
• L-shape mix bar: MU8555
• Cuvette: MU8552 (4x5 mm, 80 to 287 uL)
AU480/AU680• Lamp: MU9888
• R probe: MU9958
• S probe: MU9934
• Spiral mix bar: MU9599
• L-shape mix bar: MU8267
• AU680 Cuvette: ZM0634 (5x6 mm, 120 to 420 uL)
• AU480 Cuvette: MU8465 (5x5 mm, 90 to 350 uL)
AU2700/AU5400
• Lamp: ZM0635
• R probe: MU9958
• S1 probe: MU8206, S2 probe: MU8207
• Spiral mix bar: MU9599
• L-shape mix bar: MU8267
• Cuvette: ZM0634 (5x6 mm, 120 to 420 uL)
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New ISE Features:
• Ability to calibrate the ISE in Measure mode
• Ability to print the ISE calibration results in a list
• Ability to calibrate the ISE and perform a reagent check at the same time
• Decrease start up time
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New Software Features from AU480/AU680 Sample Status
• Order: Displays the time a sample
goes past the cup detector
• Status: Displays “In Process” while the
sample is in process Displays “Done” when the
sample is complete
• Results: Displays the time of sample
(RB, cal, QC, and patient) completion while the sample is in process
Displays a white box (no text) when the sample is complete without an error flag
Displays “Error” in red when the sample is complete with a flag on a test performed on the sample
New: RB, Cal, and QC samples can be selected and viewed in the Detail menu.
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New Software Features from AU480/AU680 Sample Status
• The ability to search and display a sample by sample ID using Search (F2)
• Direct menu access to Analyzer Status, Sample Manager, Reaction Monitor, and ISE Maintenance menus
• Direct access makes software more user-friendly
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New Software Features from AU480/AU680 Sample Status Detail
• Displays patient test results as they complete realtime
• Displays partial sample results and time to completion for each test
• “Results”: Displays the time of sample completion
• A test with an error flag displays in red. Select the test to display a description and help for the error in <Contents of Error> Operator time-savings: do
not have to access User’s Guide for flag help and corrective actions
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New Software Features from AU480/AU680 Realtime Display
• The ability to search and display a sample by sample ID using Search (F2)
• Direct menu access to Analyzer Status, Sample Manager, Reaction Monitor, and ISE Maintenance menus
• Direct access makes software more user-friendly.
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New Software Features from AU480/AU680 Analyzer Status
• Color-coding indicates the status of the component
• Select a component, and the software direct links to the appropriate menu
• Position of racks on-board the system can be identified
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New Software Features from AU480/AU680 Specific Test Parameters
• When changing between tabs, the Test Name field does not go back to Test No. 1
• A new Test No. button can be used in addition the test Name drop-down list to go to a new test
• A Select button by “Unit” opens a window with pre-programmed units
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New Software Features from AU480/AU680 Saving Parameters and Data
• A range (set the starting and ending index) of data indexes can be saved for sample, repeat, calibration, and QC data
New from AU2700/AU5400:• Parameters and data (sample,
repeat, calibration, QC) can be saved to a CD or USB
• Ability to download Reaction Monitor data to a CD or USB
• Data can be uploaded to excel, and emailed to Technical Support to aid in troubleshooting
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New Software Features from AU480/AU680 Data Print Options in List Format
• Print options for realtime and batch list formats for reagent blank, calibration, QC, and samples can be set in List Format. Previously required by BCI personnel in System Maintenance
• Print Direction: Portrait: The font is small, but
more samples print per page Horizontal: The font is larger,
but less samples print per page
• Paper Size: Set to A3, A4, Letter, Legal, or
TabloidNote: Printer Sheet Size and Sheet options in System Maintenance only affect the printout when Print (F8) is selected in a specific menu.
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New Software Features from AU480/AU680 List Format Options
In System > Format > List Format:
1. Format Test Dilution to print “Normal”, “Dilute”, or “Condense”. If formatted, “Normal” appears on all the original run tests. “Normal”, “Dilute” or “Condense” appears on the repeat run depending on the repeat criteria.
2. Format Pre-Dilution Rate to print “x 1”. If formatted, the Pre-Dilution rate entered in Specific Test Parameters prints for the original run, and the Pre-dilution rate entered in Repeat Specific prints for the repeat run.
3. Format Sample Dilution Rate to print “S. Dil. Rate x 1”. Sample Dilution Rate is a manual dilution rate made on a sample. The sample dilution rate is entered in Sample > Start Entry (F1) > Sample Dilution (F7).
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Software ChangesSpecific Test Parameters
Parameters > Specific Test Parameters
Diluent Bottle:
• Outside: Place the bottle with diluent in positions 55. Diluent/W2 and 56. Diluent/W2 outside of the R1 compartment on the analyzer
• Inside: Assign (fix) a bottle with diluent to a reagent position (1 to 54) inside the R1 compartment.
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Software ChangesReagent Management
• Dilution (DIL), Clean (CLN), and Detergent (DET) bottles are identified as “I1”, “O1”, “I2”, and “O2”.
“I” and “O” does indicates the Inner or Outer cuvette wheel.
“1” or “2” indicates the R1 or R2 refrigerated compartment.
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Software ChangesCommon Test Parameters
Parameters > Common Test Parameters > Test Name
• TBIL and DBIL are automatically assigned to Outer afterprogramming the tests in Sample Blank (F5). TBIL and DBIL can be programmed to Inner from the Test Name tab, but automatically switch to Outer and become grayed out after programming in Sample Blank (F5)
• TBIL and DBIL are automatically assigned to Inner on the AU2700 and AU5400.
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Software ChangesMulti-Rack ID
Parameters>Calibration Parameters>Calibrators
• Multi-Rack “No”:
On the AU5820, AU5830, and AU5840,Display Cup Set (F5) in the calibration requisition menu displays 1001, 2001, 3001, and 4001 for the reagent blank rack ID. Blue racks are processed simultaneously on all units
On a AU5810, multi-rack ID is not an option, and Display Cup Set (F5) in the calibration requisition menu displays 0001 for the reagent blank rack ID
• Multi-Rack “Yes”:
Not used often because it is necessary to pour multiple racks of calibrator and/or QC material.
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Software ChangeReagent Inventory
• Reagent volume required for each test by the day of the week can be calculated from data obtained from the analyzer (Auto), or a value can be entered for each test and day of the week (Manual)
• Reagent Inventory displays the number of test shots used each day of the week for each sample type within the period set by the index range
• Use Reagent Inventory to determine how much reagent should be on-board for each day of the week
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Software ChangesReagent Inventory
• Tests highlighted in green are below the Expected Volumes calculated in Reagent Inventory
• Select Inventory Check (F6) to view the Expected Volume, Onboard Volume, and Difference for each day of the week with Auto or Manual calculations
• AU480 and AU680 do not have the Inventory Check (F6) option.
• On the AU400, AU640, AU2700, and AU5400 this information could be viewed from Start Condition > Inventory Check (F8)
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Reagent ConsumptionNew Software Features from AU2700/AU5400
• Shot Total is the cumulative number of tests run on the analyzer form the installation of the instrument. (Default display)
• Select Test Shots after setting the index range and sample type. The number of reagent dispenses for each test and sample type displays. The number of Samples displays for Routine, Emergency, Repeat, and ISE
• Select Test Total after setting the index range and sample type. The number of reagent dispenses for each test and sample type displays. The number of Samples displays for Routine, Emergency, and Repeat. The number of ISE tests (Na, K, and Cl) displays.
• Reagent consumption data can be saved to a CD or USB by selecting Perform (F7)
Note: On the AU480/AU680 the option to save to a CD or USB is Report (F7)
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QC Graphs: Daily Charts MenuNew Software Features from AU2700/AU5400
• Ability to plot multiple QC points per index. AU2700/AU5400 averaged
multiple QC points per index.• 300 indexes of QC data are
automatically saved.• Highlight a date and time listed
vertically under the chart to view specific data associated with that point
• Ability to access Reaction Monitor menu directly
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Default Sample TypeNew Software Features from AU2700/AU5400
• Ability to select the default sample type in the System Condition menu:
All menus display the Default Type selected in System Condition from the “Type” drop-down
Benefit for Toxicology labs and Drugs of Abuse testing labs that only run urine samples
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Calibration ParametersNew Software Features from AU2700/AU5400
• Ability to program all calibrator concentrations for one calibrator material on one new screen.
AU2700/AU5400 required paging through each test in the Calibration Specific menu
Easier and less room for operator error on AU5800
AU2700/AU5400
AU5800
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Reagent ManagementNew Software Features from AU2700/AU5400
• Ability to monitor RB Stability, Calibration Stability, and Onboard Stability in hours After 3 days, the display
changes to hours. Example: 3D to 71H
• Ability to generate a “Calibration Expires Soon” warning for a user-defined number of hours (done in System Maintenance by BCI personnel
The programmed number of hours also generates an automatic reagent blank or calibration requisition
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Assay Specific LIHNew Software Features from AU2700/AU5400
• Sample Specific LIH: AU2700/AU5400 and
AU5800: Flags sample for the level of lipemia, icterus, and hemolysis detected
• Assay Specific LIH: AU5800 and
AU480/AU680: A specific flag is attached to the tests run on the sample that are known to be affected at a specific threshold of interference.
Barcoded LIH reagent must be used
Printout Example:S.No.0001 0003-01 S.ID 123456
CRE 0.6 CHOL 280 TBIL 0.3 DBIL 0.3 h
LIP + ICT N HEM ++
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Specific Test ParametersNew Software Features from AU2700/AU5400
Parameters > Specific Test Parameters
• Correlation Factor:
Corrects the concentration value with the equation Y = AX + B. The Correlation correction is performed after checking the dynamic range.
• Factor for Maker:
Corrects the concentration value with the equation Y = AX + B. The Factor for Maker correction is performed before checking the dynamic range.
• If a Correlation Factor and a Factor for Maker are programmed, the results are calculated with both factors.Note: Changes to Factor for Maker require a password used by the FAS
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Default QC ProfileNew Software Features from AU2700/AU5400
• Program the default QC profile for each Sample Type and Group in use in Common Test Parameters > Profile > QC.
• The default QC profile is automatically requisitioned in the QC Requisition menu.
Profile 87: Serum Group 1Profile 88: Serum Group 2Profile 89: Serum Group 3Profile 90: Urine Group 1Profile 91: Urine Group 2Profile 92: Urine Group 3Profile 93: Other-1 Group 1Profile 94: Other-1 Group 2Profile 95: Other-1 Group 3Profile 96: Other-2 Group 1Profile 97: Other-2 Group 2Profile 98: Other-2 Group 3
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QC for Calculated TestsNew Software Features from AU2700/AU5400
• Define up to 10 calculated tests in Specific Test Parameters > Calculated Tests.
• At QC Perform, select Yes to be able to program QC ranges in QC Specific for the calculated test.
• To perform QC on HbA1c, QC Specific ranges must be programmed for the % HbA1c, HbA1c, and THb tests.
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Contamination Parameters New Software Features from AU2700/AU5400
• Cleaning solution bottles for contamination prevention are located outside of the R1 and R2 refrigerators for additional onboard reagent positions compared to the AU2700/AU5400. R1: positions 57. CLN-1, 58. CLN-2,
59. CLN-1, and 60. CLN-2
R2: positions 55. CLN-1, 56. CLN-2, 57. CLN-1, and 58. CLN-2
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