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ATS 1994 Update
Areas pertinent to occupational pulmonary function testing Critical role of technician in obtaining
accurate results. Recommended changes in testing
procedure. Equipment validation. Quality control Infection control and hygiene concerns
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Spirometric testing
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Lung Volumes and Capacities Pulmonary volumes are measured Pulmonary capacities are calculated
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INDICATIONS FOR SPIROMETRY
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Indications
Primary prevention Pre-placement and fitness-for-duty examinations
Physical demands of a job (heavy manual labor, fire fighting);
Characteristics of respiratory use (prolonged use of negative-pressure mask under conditions of heavy physical exertion and/or heat stress - not required by OSHA);
Research and monitoring of health status in groups of workers.
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Indications
Secondary prevention Medical surveillance programs – workers
at risk of developing occupationally related respiratory disorders
Baseline and periodic evaluations Mandated OSHA regulations (asbestos,
cadmium, coke oven emissions or cotton dust) Local mandated medical surveillance program Component of workplace health promotion
program
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Indications
Tertiary prevention Clinical evaluation of symptomatic
individuals Restrictive Obstructive Combined ventilatory defects
Disability under Social Security Administration
Federal Coal Mine Health and Safety Act Workers’ compensation setting
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Technician Training
From Preamble to OSHA Cotton Dust Standard, 1978: “The key to reliable pulmonary function
testing is the technician’s way of guiding the employee through a series of respiratory maneuvers;
The most important quality of a pulmonary function technician is the motivation to do the very best test on every employee;
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Technician Training
The technician must also be able to judge the degree of effort and cooperation of the subject;
Test results obtained by a technician who lacks these skills are not only useless, but also convey false information which could be harmful to the employee.”
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Quality Control
Technician needs to be aware of patient-related problems when performing FVC maneuvers Submaximal effort Leaks between lips and mouthpiece Incomplete inspiration or expiration (prior
to or during forced maneuvers) Hesitation at start of the expiration
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Quality Control
Cough ( particularly within the first second of expiration)
Glottis closure Obstruction of mouthpiece by the tongue Vocalization during forced maneuver Poor posture
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Problematicexamples compared withwell-performed maneuvers.
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Quality Control
Errors that inflate test results Poor testing technique
Extra breath through nose Slight submaximal expiratory effort Accept/save curve with large hesitation, even when flagged
by spirometer Flow-type spirometer malfunctions during subject
test Inaccurate zeroing of sensor (performed before each
expiration; or Sensor characteristic change between expirations due to
warming, deposition of mucous, or condensation of water vapor.
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Problematicexamplescompared withwell-performedmaneuvers.
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Quality Control
Error that reduce test results Leaks in volume spirometer or breathing
tubes Reduce FVCs significantly but are not visible in
spirograms until leak is very large Checking for leaks at least daily in the
calibrations check is essential
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Quality Control
Hygiene and Infection Control Recommendation:
Direct contact– Potential for transmission of URI, enteric infections,
and blood borne infections;– Most likely surface for contact are mouthpieces and
immediate proximal surface of valves or tubing.
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Quality Control
Recommendation: Indirect contact
Potential for transmission of TB, various viral infections, and possible opportunistic infections and nosocomial pneumonia;
Possible contamination of mouthpieces and proximal valves and tubing.
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Quality Control
Prevention Proper hand washing and/or use of barrier device. Use of disposable mouthpieces, nose clips, etc. Spirometers using close circuit technique should
be flushed at least five time over entire volume range.
Provide proper attention to environmental engineering control where TB or other diseases are spread by droplet nuclei might be encountered.
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Quality Control
Prevention Take special precaution when testing patients with
hemoptysis, open sores on oral mucosa, or bleeding gums.
Extra precautions with know transmissible infectious diseases.
Regular use of in-line filters (not mandated). Manufacturers encouraged to design
instrumentation that can be easily disassembled for disinfection.
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Quality Control
Equipment quality control Volume
Must be checked at least daily with a 3-liter calibrated syringe.
Syringe accuracy Calibration syringe must have an accuracy of at least 15
ml or at least 0.5% of full scale (15 ml for a 3-liter syringe.
Leak test Volumetric spirometry systems must be checked daily.
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Quality Control
Equipment quality control Linearity
Volume spirometers must have their calibration checked over the entire volume range quarterly (in one liter increments).
Time Assessing mechanical recorder time scale accuracy with a
stopwatch must be performed at least quarterly. Other QA procedures
Calibration with physical standard (practice of using laboratory personnel as “known subjects”)
Adhere to ATS recommendations for computer software for spirometers.
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Quality Control
Equipment Quality Control
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Spirometry Parameters
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Spirometry Parameters
Forced Vital Capacity FVC
Forced Expiratory Volume in One Second FEV1
Forced Expiratory Volume in One Second Expressed as a Percentage of the Forced Vital Capacity FEV1/FVC %
Mean Forced Expiratory Flow during the Middle Half of the Forced Vital Capacity FEF 25-75%
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FVC
Definition: Defined as the maximal amount of air that
can be exhaled forcefully after a maximal inspiration or the most air a person can blow out after taking the deepest possible breath.
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FVC - forced vital capacity defines maximum volume of exchangeable air in lung (vital capacity)
forced expiratory breathing maneuver requires muscular effort and some patient training
initial (healthy) FVC values approx 4 liters slowly diminishes with normal aging
significantly reduced FVC suggests damage to lung parenchyma restrictive lung disease (fibrosis) loss of functional alveolar tissue (atelectasis) FVC volume reduction trend over time (years) is key indicator
intra-subject variability factors age sex height ethnicity
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FVC
End of Test Criteria The volume time curve show an obvious
plateau Plateau defined as no change in volume for at
least one second. Subject cannot or should not continue further
exhalation. The forced expiration is of reasonable duration.
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PEF
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FEV1
Definition: The volume of air exhaled during the first
second of a forced expiratory maneuver. normal FEV1 about 3 liters FEV1 needs to be normalized to individual’s
vital capacity (FVC)
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FEV1
Steps for determination of the FEV1: Determine Time Zero using the back
extrapolation technique; Measure over one second from Time Zero; Draw a straight line up from the point
where Time = one second and the point where the straight line intersects is the FEV1.
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PEF
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FEV1/FVC% Definition:
The value expresses the volume of air the worker exhales in one second as a percent of the total volume of air that is exhaled.
Calculated by using largest valid FEV1 and largest FVC even if they are not from the same tracing.
Find largest valid FEV1 Find largest valid FVC Divide FEV1 by FVC Multiply by 100 to obtain percentage.
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FEF25-75%
Definition: The mean expiratory flow during the middle
half of the FVC More sensitive than FEV1. Considerably more variability than FVC and
FEV1. ATS recommends only be considered after
determining presence and clinical severity of impairment and should not be used to diagnosis disease in individual patients
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PEF - Peak Expiratory Flow rate measures airflow limitations in large (central) airways
large airways are rate-limiting for airflow in healthy patients large airway flow limitations important in asthma
PEF measurements recommended for asthma management spirometry is recommended to help make the diagnosis of asthma
PEF not recommend to evaluate patients for COPD cannot measure small airway airflow limitations
advantages of PEF tests measurements within a minute (three short breaths) uses simple, safe, hand-held devices that typical, costs $20
disadvantages of PEF tests (compared to spirometry) insensitive to obstruction of small airways (mild or early obstruction) PEF is very dependent on patient effort (large intra-subject variability) mechanical PEF meters are much less accurate than spirometers
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BTPS
Definition: Gas (air) at:
Body Temperature (37°C) Ambient Pressure (surrounding air pressure) Saturated with water vapor (relative humidity =
100% as is the case in the lungs)
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BTPS
Spirometric test requiring conversion to BTPS FEV1, FVC, and FEF25-75% all represent
volume (volume per unit of time) – must be converted to BTPS.
FEV1/FVC% is ratio of volumes – does not have to be converted.
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BTPS
Points to remember: Temperature
Ambient temperatures should be recorded to within 1°C.
Spirometric testing should only be done with ambient temperatures between 17° - 40°C.
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Reproducibility (Variability)
ATS recommends obtaining three (3) valid tracings with reproducible FVC’s and FEV1. The two largest valid FVC’s are examined
to determine there is no more than a .2 liter (200 ml) difference between them.
The two largest valid FEV1 are examined to determine there is no more than a .2 liter (200 ml) difference between them.
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Points to Remember FVC
Convert answer to BTPS when needed.
FEV1 Excessive variability and
extrapolated volume must be calculated to determine if additional maneuvers are needed.
Convert to BTPS when needed. FEV1 and FVC
Always use largest volume from an acceptable tracing to ensure maximal results.
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Performance Maneuvers
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Performance
Subject Instruction and Maneuver Performance Recommendations:
Technicians should demonstrate appropriate technique.
Imperative to have a complete inhalation before subject “blasts” the air out.
Enthusiastically coach subject. Observe subject and chart recorder during test
to better ensure maximal effort.
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Performance
Recommendations Perform a minimum of three acceptable FVC
maneuvers. May require up to eight maneuvers be
performed if subject shows large variability between expiratory maneuvers.
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Performance
Start-of-Test Criteria Recommendation:
To achieve accurate “time zero”, the FEV1 must come from a maximal effort curve.
Extrapolated volume must be less than 5% of the FVC or 0.15 liter, whichever is greater.
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Performance
Minimum exhalation time Minimum exhalation time
of 6 seconds (length of maximum expiratory effort).
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Performance
End of Test Criteria Subject cannot or should not continue
further exhalation. Volume-time curve show an obvious
plateau. To meet ATS criteria, the minimal detectable
volume for spirometers must be 30 ml or less for at least one second.
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Performance
End of test criteria Forced exhalation is of reasonable duration
Multiple prolonged exhalations.– May cause light headedness, undue fatigue, and
unnecessary discomfort.– Exhalations greater than 15 second rarely change
medical decisions.
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Performance
Maximum number of maneuvers. Eight maneuvers is
considered a practical upper limit for most subjects.
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Performance
Environmental conditions Ambient temperature must always be
recorded and reported to an accuracy of + 1° C.
17° C is judged to be acceptable and reasonable lower limit.
– Some subjects may develop airflow limitations with the inhalation of very cold air.
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Performance
Use of nose clips Recommendation:
Nose clips are not required when doing open circuit technique; however some people breathe through the nose and use of nose clips is encouraged.
Sitting vs. Standing Recommendation:
Testing may be done either in the sitting or standing position; indication of position is necessary on the report.
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Performance
Measurement Recommendation:
Largest FVC and FEV1 should be recorded after examining data from all the acceptable curves, even if they do not come from the same curve.
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Performance
Maneuver acceptability Technician must perform test without:
An unsatisfactory start of expiration – characterized by extrapolated volume of greater than 5% of FVC or 0.15 L, whichever is greater.
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Performance
Coughing during the first second of maneuver, or any cough in the technician's judgment that interferes with measurement of accurate results.
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Performance
Early termination of expiration.
Valsalva maneuver (glottis closure) or hesitation during the maneuver that causes a cessation of airflow.
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Performance
Leaks
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Performance
An obstructed mouthpiece (obstruction due to the tongue being placed in front of the mouthpiece or false teeth falling in front of the mouth piece).
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Performance
Test result reproducibility The largest FVC and second largest FVC
from acceptable maneuvers must not vary by more than 0.2 Liter (200 ml).
The largest FEV1 and second largest FEV1 from acceptable maneuvers must not vary by more than 0.2 Liter (200 ml).
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Summary
Acceptability and Reproducibility Criteria: Acceptability criteria
Individual spirograms are “acceptable” if:– Are free from artifacts
• Cough or glottis closure during the first second of exhalation
• Early termination or cutoff
• Variable effort
• Leaks
• Obstructed mouthpiece
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Summary
Have a good start.– Extrapolated volume less than 5% of FVC or 0.15 L,
whichever is greater
Have a satisfactory exhalation.– 6 second of exhalation and/or a plateau in the
volume-time curve; or– Reasonable duration or a plateau in the volume-time
curve; or – If the subject cannot or should not continue to
exhale.
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Summary
Reproducibility criteria After three (3) acceptable curves obtained:
Are two largest FVCs within 0.2 L of each other? Are two largest FEV1s within 0.2 L of each other?
If YES to both, may conclude test session. Otherwise, continue testing until:
Both criteria are met after additional curves are recorded; or A total of eight tests have been performed; or The subject cannot or should not continue.
At a minimum, save the three best maneuvers.
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