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NADH

NADH+FADH

Summary of ATP Producing PathwaysSummary of ATP Producing Pathways

2 ATP 2 ATP 32 ATP = 36 ATP

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Review Sheet«..

ATP + H2O ADP + Pi + energy (7.3 kcal)

ADP + Pi + energy ATP + H2O

Adenosine triphosphatase

(1)

(1b)

Start

Finish

(2)

Creatine kinase

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Glycolysis«. 10 Steps «.

Step 1Glucose 

Glucose-6-phosphate 

Fructose-6-phosphate 

Fructose-1-6-bisphosphate 

ATP

ADP

ATP

ADP

Step 2

Step 3

Step 4Dihydroxyacetone 

phosphate Glyceraldehyde-3-

phosphate Step 5

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2-phosphoenolpyruvic acid

Pyruvic Acid

Glycolysis«. 10 Steps con¶d

Step 61-3-bisphosphoglyceric acid

3-phosphoglyceric acid

ADP

ATP

ADP

ATP

Step 7

Step 8

Step 9

Glyceraldehyde-3-phosphate 

2-phosphoglyceric acid

Step 10

2 Pyruvic Acid 2 Net ATP 2 NADH+H

NAD+

NADH+H

H2O

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Summary Of Glycolysis

1.Glucose enters the Cell

2.Glycolysis re-arrangesGlucose 10 times

3.At steps 1 and 3 ATP is Consumed 

4.Step 7 PRODUCES 2 ATP, step 10 PRODUCES 2 ATP

5.The final products are 

1. Two Pyruvic Acid molecules

2. Two N  ADH + H + molecules

3. A NET ATP production of 2

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NAD

NADH+H+NAD

NADH+H+

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2 pyr uvic acid 

2 ATP

GlycolysisG

lycolysis

Lactic acid K r ebs cycle

Insufficient 

amounts of O2

H+

Sufficient amounts 

of O2 pr esent

H+ + pyr uvic acid

2 NADH + H+

Sufficient amounts of O2 pr esent

Electr on trans por t 

chain

H+

1.2.

3.

Last Class we summarized«

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8 Steps of the Kreb¶s Cycle

(C)-Can

(I)- I

(K)- Keep

(S)- Some

(S)- Salt(F)- For 

(M)- My 

(O)- Omelette

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Oxaloacetic Acid

Krebs Cycle 8 steps + Intermediate

Intermediate Pyru

v

ic Acid

Acetyl CoA

Citric Acid

Isocitric Acid

CO2

Step 2

Step 4

Step 5

E-K etoglutaric Acid

Step 6

Succinyl-CoA

NAD+

NADH+H

NAD+

NADH+H

NAD+

NADH+H

CoA

CO2

CoA

CO2

CoA

CoA

Succinic Acid

Fumaric Acid

NAD+

NADH+H

GTP GDP + Pi

Malic Acid

FAD

FADH2

Step 3Step 7

Step 8 Step 1

ADP ATP

Cytosol

Mitochondria

Matrix

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MitochondrionMitochondrion

Pyruvic Acid

Kreb¶s

Cycle 

 NADH+H

FADH

ETCETC

III IIIQ

IV

C

ATP

Synthase

Mitochondrial matrix

Inner Mitochondrial Membrane 

NADH FADH2

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Oxidative Phosphorylation and The 

Electron Transport Chain

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Oxidative Phosphorylation and The 

Electron Transport Chain

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Lipid Metabolism: The Glycerol PathwayLipid Metabolism: The Glycerol Pathway

Glycerol:1.Is detached f r om the tr iglycer ide por tion of  f at 

2. Glycer ol is then conver ted into 

glyceraldehyde-3- phos phate

3. Glyceraldhyde-3- phos phate will then enter into glycolysis 

4. Like glucose, it is conver ted into 

acetyl CoA, and then enter s the K r ebs cycle

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Figure

23.13

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How many ATP would a 22 car  bon tr iglycer ide make?

Practice Question Number 3Practice Question Number 3

22

22

22

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How many ATP would a 22 car  bon tr iglycer ide make?

Practice Question Number 3Practice Question Number 3

22 Carbon Fatty Acid«.

Part 1. Acetyl-CoA

=Carbon chain/ 2=22/2

=11 Acetyl-CoA

Acetyl-CoA (1 tur n) K r eb = 12 ATP

Part 2. NADH+H+/ FADH2

= # Acetyl-CoA - 1

=10 molecules each

Ther efor e, total ATP par t 1 

= 1

2 ATP x11

Acetyl-CoA = 132 ATP

Total= = 182 ATP

In ETC- 1 NADH+H+ x 3 ATP + 1 FADH2 x 2ATP = 5 ATP

Ther efor e, total ATP par t 2

= 5 ATP x 10 = 50 ATP

132 ATP + 50 ATP

= 18 ATP (Glycer ol) + (3 x ATP f r om 1 car  bon chain)

= 18 ATP + (3 x 182 ATP) = 564 ATP

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Lipogenesis and LipolysisLipogenesis and Lipolysis

Figure 23.14

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A Summary of the breakdown of Glucose«A Summary of the breakdown of Glucose«

Lets star t with 1 glucose molecule and see how many ATP we 

 pr oduce  by  br eaking that down

(1) GlycolysisGlycolysis

- Will yield 2 ATP and 2 NADH+H+

Assuming enough Oxygen is present in the cell «.Assuming enough Oxygen is present in the cell «.

The final pr oducts of  glycolysis, 2 pyr uvic acids, will enter 

the K r eb¶s cycle,

However the pyr uvates must under go a µintermediate step¶

(conver sion into acetyl CoA) which will pr oduce 2 NADH+H+

The Krebs Cycle 

- Each Acetyl CoA will go thr ough one cycle, the total will  be 

2 ATP¶s, 6 NADH+H+

and 2 FADH2

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- The 6 NADH+H6 NADH+H++ and 2 FADH2 FADH22 f r om the K r ebs cycle will go on to the ETC to pr oduce a total of  22 ATP22 ATP

Don¶t FOR GETDon¶t FOR GET

- Glycolysis made 2 NADH+H2 NADH+H++,  these pr oducts pr oduce 4 ATP4 ATP

- The µintermediate step¶µintermediate step¶ of  the K r ebs Cycle also 

 pr oduced  2 NADH+H2 NADH+H++ and this will make 6 ATP¶s6 ATP¶s

A Summary of the Breakdown of Glucose

TOTAL= 2+2+22+4+6

Total = 36 ATP¶s/ Molecule of Glucose