ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological...
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ASX:LCT.AX OTC:LVCLY.PK
A personal perspective and a glimpse of the future
School of Biological Sciences, 11 March 2011
Professor R. B. Elliott on behalf of Living Cell Technologies
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The Story begins - 1961
George Maxwell
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Paul Lacey
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1961
Transplant new cells from rats into anterior eye chamber of the eye of diabetic rabbits---failed.
Transplant rat islets inserted into a semi permeable chamber inserted under the skin of diabetic rabbits----- failed
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1976
Transplant human foetal islets
intramuscularly into Type 1 diabetic
humans------ failed
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1995
Transplant newborn pig islets into peritoneal cavity of humans with T1D failed
David Collinson
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1996
Transplant newborn pig islets
encapsulated into semi-permeable
microcapsules
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Michael Helyer - 1996
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Michael Helyer - 2005
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1996 – 2007
Virtual moratorium PERV
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Auckland Islands
Auckland Islands, New Zealand.
• Unique source . NO xeno-relevant viruses, bacteria and parasites.
NULL PIGS (PERV).• Herd now bred in documented bio-isolation.
• Three year health records and regular monitoring. Three generations without mammalian content in feed.
• Health Monitoring. Regular testing by IANZ accredited laboratory for all of herd and all donors.
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Facilities
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Encapsulated Islet
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Russian Patient Video
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Dr. Paul Tan
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NZ Study - Patient # 1 Result
-8 -6 -4 -2 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 42 44 46 48 50 520
1
2
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Patient #1: Asymptomatic Hypos
Week Number
Num
ber o
f Asy
mpt
omati
c Hyp
os
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Choroid Plexus
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Choroid Plexus
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Dopamine containing cells
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Monkey Study Results
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Other Projects
• Restoring auditory nerves
• Liver cells for haemophilia
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Other studies under way
• Regeneration of auditory spiral ganglion cells
• Human cells for replacement of the clotting factor V111, haemophilia
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For future other possibilities
Providing biologics in excess to treat non-deficiencydiseases
Cells over expressing therapeutics
E.g. localised delivery of TNF for cancer treatmentIntestinal L cells for obesity
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Living cell treatment is an exciting new frontier, which
skilled biologists need to explore.
The rewards are likely to be high.
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There is nothing more difficult to take in hand, more perilous to conduct, or more uncertain in its success, than to take the lead in the introduction of a
new order of things.
Niccolo Machiavelli