ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological...

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ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological Sciences, 11 March 2011 Professor R. B. Elliott on behalf of Living Cell Technologies

Transcript of ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological...

Page 1: ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological Sciences, 11 March 2011 Professor R. B. Elliott on behalf.

ASX:LCT.AX OTC:LVCLY.PK

A personal perspective and a glimpse of the future

School of Biological Sciences, 11 March 2011

Professor R. B. Elliott on behalf of Living Cell Technologies

Page 2: ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological Sciences, 11 March 2011 Professor R. B. Elliott on behalf.

The Story begins - 1961

George Maxwell

Page 3: ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological Sciences, 11 March 2011 Professor R. B. Elliott on behalf.

Paul Lacey

Page 4: ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological Sciences, 11 March 2011 Professor R. B. Elliott on behalf.

1961

Transplant new cells from rats into anterior eye chamber of the eye of diabetic rabbits---failed.

Transplant rat islets inserted into a semi permeable chamber inserted under the skin of diabetic rabbits----- failed

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1976

Transplant human foetal islets

intramuscularly into Type 1 diabetic

humans------ failed

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1995

Transplant newborn pig islets into peritoneal cavity of humans with T1D failed

David Collinson

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1996

Transplant newborn pig islets

encapsulated into semi-permeable

microcapsules

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Michael Helyer - 1996

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Michael Helyer - 2005

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1996 – 2007

Virtual moratorium PERV

Page 11: ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological Sciences, 11 March 2011 Professor R. B. Elliott on behalf.

Auckland Islands

Auckland Islands, New Zealand.

• Unique source . NO xeno-relevant viruses, bacteria and parasites.

NULL PIGS (PERV).• Herd now bred in documented bio-isolation.

• Three year health records and regular monitoring. Three generations without mammalian content in feed.

• Health Monitoring. Regular testing by IANZ accredited laboratory for all of herd and all donors.

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Facilities

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Encapsulated Islet

Page 14: ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological Sciences, 11 March 2011 Professor R. B. Elliott on behalf.

Russian Patient Video

Page 15: ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological Sciences, 11 March 2011 Professor R. B. Elliott on behalf.

Dr. Paul Tan

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NZ Study - Patient # 1 Result

-8 -6 -4 -2 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 42 44 46 48 50 520

1

2

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Patient #1: Asymptomatic Hypos

Week Number

Num

ber o

f Asy

mpt

omati

c Hyp

os

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Choroid Plexus

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Choroid Plexus

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Dopamine containing cells

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Monkey Study Results

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Other Projects

• Restoring auditory nerves

• Liver cells for haemophilia

Page 23: ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological Sciences, 11 March 2011 Professor R. B. Elliott on behalf.

Other studies under way

• Regeneration of auditory spiral ganglion cells

• Human cells for replacement of the clotting factor V111, haemophilia

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For future other possibilities

Providing biologics in excess to treat non-deficiencydiseases

Cells over expressing therapeutics

E.g. localised delivery of TNF for cancer treatmentIntestinal L cells for obesity

Page 25: ASX:LCT.AX OTC:LVCLY.PK A personal perspective and a glimpse of the future School of Biological Sciences, 11 March 2011 Professor R. B. Elliott on behalf.

Living cell treatment is an exciting new frontier, which

skilled biologists need to explore.

The rewards are likely to be high.

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There is nothing more difficult to take in hand, more perilous to conduct, or more uncertain in its success, than to take the lead in the introduction of a

new order of things.

Niccolo Machiavelli