ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical,...
Transcript of ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical,...
![Page 1: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/1.jpg)
ASTRO Contouring for Lymphoma
Stephanie Terezakis, MD
![Page 2: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/2.jpg)
• Accurate target volume definition crucial for
conformal RT and INRT
1970 – Total Lymphoid Irradiation (TLI)
Figure courtesy of Dr. Joachim Yahalom
1995 – Involved-Field Radiotherapy (IFRT)
2008 – Involved Node Radiotherapy (INRT)
![Page 3: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/3.jpg)
Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular,
axillary, and mediastinal/hilar regions
• Treatment of paraaortics, spleen, pelvic, and inguino-femoral nodes
• Significant dose inhomogeneity can result due to differences in patient thickness
![Page 4: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/4.jpg)
Involved Field (~Year 2000)
• The site of the clinically involved lymph node group
• Lymph node grouping not clearly defined
• For extra-nodal sites – the organ alone (if no evidence for lymph node involvement)
![Page 5: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/5.jpg)
HD Staging Regions (1971):
not an involved-field chart
![Page 6: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/6.jpg)
IFRT – Cervical Chain
• Unilateral or bilateral neck nodes including supraclavicular region extending from skull base to clavicle(s)
• Patient positioned supine with Aquaplast mask
• Oral cavity block placed if tumor coverage will not be compromised
![Page 7: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/7.jpg)
Neck Treatment Positioning
Neutral Hyperextended
![Page 8: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/8.jpg)
Neck Treatment Positioning
Neutral Hyperextended
![Page 9: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/9.jpg)
IFRT – Axillary Field
• Treatment of axillary, supraclavicular, and infraclavicular nodes
• Superior border – C5-C6 interspace
• Inferior border – Tip of scapula or 2 cm below most inferior node
• Medial border – Ipsilateral transverse process
• Lateral border – Flash axilla
![Page 10: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/10.jpg)
Arm Positioning
• Arms overhead or akimbo
• Raising arms alters axillary lymph node position
![Page 11: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/11.jpg)
IFRT - Mediastinum
• Mediastinal nodes, bilateral hila, and bilateral supraclavicular nodes
• Superior border – C5-C6
• Inferior border – 2 cm below pre-chemotherapy extent
• Lateral border – 1.5 cm on post-chemotherapy volume
![Page 12: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/12.jpg)
IFRT – Para-aortics/Groin
• Para-aortic +/- spleen : T10-T11 down to L4-L5
• Groin: External iliac, femoral, and inguinal lymph nodes
• Account for spleen respiratory motion
![Page 13: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/13.jpg)
• Definitions of IFRT dependent on bony landmarks without 3D target delineation
• Involved-nodal radiotherapy (INRT) was introduced in Europe for
Hodgkin Lymphoma and markedly reduced the irradiated volume
• INRT design requires accurate pre-chemo or pre-biopsy information
obtained in the treatment position
The Evolution of INRT and ISRT
INITIAL TUMOR MASS
TUMOR REMNANTS
CTV(prechemo length
and postchemo width)
PTV=CTV+1 CM
![Page 14: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/14.jpg)
Principles of ISRT
• ISRT utilizes ICRU definitions ▫ Ideal to take advantage of pre-treatment imaging
▫ ISRT recognizes detailed pre-treatment evaluation may not always be optimal
▫ In most cases, smaller volumes than IFRT
• Planning requirements: CT-based simulation
• Goal to target site of originally involved lymph node(s) ▫ Field encompasses the original volume prior to surgery or
chemotherapy
▫ Spares uninvolved organs once lymph node has regressed
![Page 15: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/15.jpg)
CT Simulation
• CT simulation with IV contrast for accurate identification of vessels, heart, kidneys, and spleen
• Immobilization is site specific
![Page 16: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/16.jpg)
Target Volumes
• Pre-chemotherapy Gross Tumor Volume (GTV) ▫ Pre-chemotherapy or pre-surgery volume ▫ Should be encompassed by the CTV taking into
account change in normal anatomy after initial treatment response
• Post-chemotherapy GTV ▫ Potential Boost
• Clinical considerations must ultimately be used to
determine the final CTV
![Page 17: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/17.jpg)
Target Volumes
• Certain sites may be subject to internal motion
▫ If necessary the CTV may be expanded to the ITV (internal target volume) using either 4D-CT or fluoroscopy
• CTV (or ITV) expansion to the planning target volume (PTV) depends on expected daily setup uncertainty ▫ Immobilization device or patient setup ▫ Body site ▫ Individual characteristics
![Page 18: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/18.jpg)
Treatment Planning
• Organs at risk (OAR) should be identified and contoured
• For many cases, conventional treatment may still be appropriate
• 3D-CRT or IMRT techniques should be considered depending on clinical judgment, individual treatment characteristics and availability considerations
![Page 19: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/19.jpg)
![Page 20: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/20.jpg)
Case Example
• 37 year old female
• Progressing shortness of breath over 1 month
• Chest CT scan demonstrates large mediastinal mass
• Excisional biopsy performed: Nodular sclerosing Hodgkin lymphoma
• PET/CT =Uptake in bulky mediastinal lymph nodes and right subpectoral region
• Treatment Plan:
▫ ABVD x 6 + Involved site RT
![Page 21: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/21.jpg)
Pre-chemotherapy PET/CT
![Page 22: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/22.jpg)
![Page 23: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/23.jpg)
![Page 24: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/24.jpg)
![Page 25: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/25.jpg)
![Page 26: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/26.jpg)
![Page 27: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/27.jpg)
Pre-chemotherapy PET/CT
![Page 28: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/28.jpg)
Post-chemotherapy PET/CT
• PET was negative after cycle 3 and at end of all 6 chemotherapy cycles
• Referral for radiation treatment
• ISRT recommended per new guidelines
![Page 29: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/29.jpg)
Simulation
• CT Simulation performed with IV contrast
• Right arm up
• Patient immobilized in alpha cradle
• AP/PA plan with segments
![Page 30: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/30.jpg)
R atrial app PA
SVC
Aorta
![Page 31: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/31.jpg)
R atrium RV
L atrium
Aortic Root
![Page 32: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/32.jpg)
RV
LV
![Page 33: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/33.jpg)
![Page 34: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/34.jpg)
Comparison of IFRT and ISRT
IFRT ISRT
![Page 35: ASTRO Contouring for Lymphoma...Extended Field • Supradiaphragmatic nodes including cervical, supraclavicular, axillary, and mediastinal/hilar regions • Treatment of paraaortics,](https://reader030.fdocuments.us/reader030/viewer/2022040805/5e44bc30f00e5f57d915f77e/html5/thumbnails/35.jpg)
Thank You