Asthma Ppt

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ASTHMA Khurram Aamir Pharm-D MPhil Pharmacology & Toxicology

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Asthma ppt

Transcript of Asthma Ppt

ASTHMA Khurram AamirPharm-D MPhil Pharmacology & ToxicologyINTRODUCTIONAsthma is th chro!ic i!"ammatory #isor#r o$ air%ays i! %hich ma!y clls a!# cllular lm!ts li& mast clls' osi!o(hils' T lym(hocyts' macro(hags' !utro(hils' a!# (ithlial clls ar i)ol)#*I!"ammatio! causs rcurr!t (iso#s o$ %h+i!g' ,rathlss!ss' chst tight!ss' a!# coughi!g (articularly at !ight a!# i! mor!i!g*INTRODUCTIONAir%ayo,structio!occur#uto co!tractio!o$smoothmusclso$ ,ro!chiols Smoothmusclshy(rtro(hya!# hy(r(lasia I!"ammatory clls i!-ltratio! O#ma .o,ltcllsa!#mucousgla!# hy(r(lasia Proti! #(ositio! i!clu#i!g collag! RISK /ACTORSPot!tialtriggrs$orthi!"ammatory (rocss i!clu#Allrgy0iral rs(iratory i!$ctio!.astro-oso(hagal r"ux #isasIrrita!tssuchasto,accosmo&'air (olluta!ts' a!# occu(atio!al #ust' gass a!#chmicals!o!s(ci-cstimulisuch as col# air x(osur a!# xrcis*PATHOPH1SIO2O.1Stu#is#uri!glast34yarsha) r)al# 5 (ri!ci(l mcha!isms T hl(r cll (ath%ayIg6 m#iat# mcha!ism7oththsmcha!ismsla#sto i!"ammatio!o$thair%aysa!# la#s to o,structio! o$ air%ays*T H62P6R C622 M6DIAT6D PATH8A1Thl(rty(5cllsrlas cyto&i!s that i!clu# I2-9' I2-4' I2-:' a!#I2-;3allo$%hichco!tri,utto )ariousma!i$statio!so$allrgic i!"ammatio! a!# #isas*I2-9a!#I2-;3(r#omi!a!tlyact #irctlyo!air%aysmoothmuscls a!#(ithliumtolicit hy(rs!siti)ityractio!'!ha!c# glyco(roti!(ro#uctio!'a!# osi!o(hilia*M6CHANISMSIg6 M6DIAT6D PATH8A1Ty( ; or imm#iat hy(rs!siti) rs(o!s is m#iat#,yIg6a!a!ti,o#yisoty((ro#uc# ,y 7 clls acti)at# ,y I2-9*Circulati!gIg6ca(tur#,yIg6Rc(tors (rs!t o! ctio! sitSy!co( a!# su##! #ath #u to su##! $all i! ,loo# (rssur a!# )!tricular arrhythmias*A!ticholi!rgics Ths#rugscaus,ro!cho#ilatio!,y,loc&i!g choli!rgicrc(torsa!#acts(rimarilyi! largr air%ays*I!hal#i(ratro(ium,romi#islssKcacious tha! Sym(athomimtics*Pati!tso$asthmatic,ro!chitis'COPDa!# (sychog!icasthmars(o!#,ttrto A!ticholi!rgicsThy(ro#ucslo%rrs(o!stha!i!hal# Sym(athomimticsa!#ar,ttrsuit#$or rgular (ro(hylactic usCo!ti!uGGI(ratro(ium5-9(u