PASTEUR COURSE

VACCINOLOGY

PROGRAM 2017-2018

FEBRUARY 12 – MARCH 9, 2018 INSTITUT PASTEUR, PARIS

PROGRAM OF THE VACCINOLOGY COURSE

(12th February – 9th March, 2018)

DIRECTORS OF THE COURSE

Armelle PHALIPON Molecular Microbial Pathogenesis Unit

INSERM U1012, Institut Pasteur

Béhazine COMBADIERE Skin, immunity and Vaccination Lab

Inserm 1135 Centre d’Immunologie et

des Maladies infectieuses - Cimi-Paris

The Institut Pasteur and the organizers warmly thank Sanofi Pasteur

for its generous contribution to the Vaccinology course by sponsoring fellowships.

We are also grateful to the following sponsors for fellowships:

E-learning and workshops are made in collaboration with HSeT Foundation.

SUMMARY

This course offers an integrated overview of Vaccinology by covering all the key issues of vaccine development from design to delivery to the populations in industrialized and

developing countries. The course aims at providing the attendees with the knowledge

required to become future actors of the international vaccine community. In addition, the worldwide network built-up by the participants over the years helps the emergence of

regional/international collaborations. The course encompasses 4 modules: (i)

Introduction to Vaccinology an integrative discipline, (ii) Basic principles of preclinical

and clinical steps, (iii) Vaccines developed against major infectious diseases, (iv) Future challenges. Besides lectures, time for discussion with the lecturers on a daily-basis and

one e-learning-based workshop on design of a vaccine (against malaria, this year) are

key points in the training of the participants.

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MODULE I : INTRODUCTION TO VACCINOLOGY, AN INTEGRATIVE DISCIPLINE

MONDAY, FEBRUARY 12 14:00 - 15:00 Introduction to the course Armelle PHALIPON Béhazine COMBADIERE Registrar’s office and Education Center presentations 15:00 - 16:00 The Pasteurian contribution to the history of vaccines Marc GIRARD (Académie de Médecine) 16:00 - 16:30 Coffee break 16:30 - 18:00 Short presentations of students Armelle PHALIPON Béhazine COMBADIERE TUESDAY, FEBRUARY 13 9:00 - 10:30 The legacy of smallpox eradication: immunization Daniel TARANTOLA strategies to control, eliminate or eradicate (Consultant, France) vaccine-preventable diseases 10:30 - 11:00 Coffee break 11:00 - 12:30 Poliovirus: the next successful eradication story? Francis DELPEYROUX (Institut Pasteur, France) 12:30 - 14:00 Lunch 14:00 - 15:00 Sharing experience session: Eradication, elimination or control? (D. Tarantola, F. Delpeyroux, B. Combadière, A. Phalipon) 15:00 - 17:00 Presentation of the Workshop Malaria Vaccine Design Armelle PHALIPON Béhazine COMBADIERE WEDNESDAY, FEBRUARY 14 9:00 - 10:30 Epidemiology of infectious diseases: prerequisite for Helen CAMPBELL decision-making in vaccine development (Public Health England, UK) 10:30 - 11:00 Coffee break 11:00 - 12:30 Mathematical modeling of infectious disease Peter WHITE transmission (Imperial College, UK) 12:30 - 14:00 Lunch

14:00 - 15:00 Sharing experience session: Epidemiology pre-post vaccination? (H. Campbell, P. White, B. Combadière, A. Phalipon) 15:00 - 15:30 Coffee break 15:30 - 17:30 Preparation Workshop Malaria Vaccine Design Armelle PHALIPON Béhazine COMBADIERE THURSDAY , FEBRUARY 15 9:00 - 10:30 What a vaccinologist should know about the basic Béhazine COMBADIERE aspects of immune responses (CIMI, France) 10:30 - 11:00 Coffee break 11:00 - 13:00 Measurement of immune responses Marie-Lise GOUGEON (Institut Pasteur, France) 13:00 - 14:30 Lunch 14:30 - 15:30 Immunological memory: the challenge of conferring Rafick-Pierre SEKALY long-term protection? (Case Western Reserve Univ, USA) 15:30 - 16:00 Coffee break 16:00 - 17:00 Vaccinomics: the future of vaccinology? Rafick-Pierre SEKALY (Case Western Reserve Univ, USA) FRIDAY, FEBRUARY 16 9:00 - 10:30 Adjuvants: past and future directions Giuseppe DEL GIUDICE (GSK, Italy) 10:30 - 11:00 Coffee break 11:00 - 12:30 Vaccination in pregnant women Flor MUNOZ-RIVAS (Baylor College of Medicine, USA) 12:30 - 14:00 Lunch 14:00 - 15:30 Hurdles to vaccination in early life: revisiting Arnaud MARCHANT immunological immaturity in human newborns (Univ. Libre de Bruxelles, Belgium) 15:30 - 16:00 Coffee break 16:00 - 17:00 Sharing experience session: What is the future for mother versus newborn vaccination and adjuvants? (F. Munoz, A. Marchant, G. Del Guidice, B. Combadière, A. Phalipon)

MONDAY, FEBRUARY 19 9:00 - 10:30 Novel strategies for delivering vaccines Béhazine COMBADIERE (CIMI Paris, France) 10:30 - 11:00 Coffee break 11:00 - 12:30 Mucosal immunity: advantages and limitations Cecil CZERKINSKY in developing mucosal vaccines (IPMC, France) 12:30 - 14:00 Lunch 14:00 - 15:30 Sharing experience session: How to choose the appropriate strategy? (C. Czerkinsky, B. Combadière, A. Phalipon) 15:30 - 16:00 Coffee break 16:00 - 17:00 Preparation Workshop Malaria Vaccine Design Armelle PHALIPON Béhazine COMBADIERE

MODULE II: PRECLINICAL AND CLINICAL STEPS: BASIC PRINCIPLES

TUESDAY , FEBRUARY 20 9:00 - 10:30 GMP production: which prerequisites and Stephen BROWN how to proceed (BE Vaccines SAS, France) 10:30 - 11:00 Coffee break 11:00 - 12:30 Preclinical safety testing of vaccines Roy FORSTER (CIToxLAB, France) 12:30 - 14:00 Lunch 14:00 - 16:00 Phase I/II vaccine trials: methodology and implementation David LEWIS (University of Surrey, UK) 16:30 - 18:00 Correlates of vaccine-induced immunity - Current problems Stanley PLOTKIN in vaccine development and possible solutions (Vaxconsult, USA) WEDNESDAY, FEBRUARY 21 9:00 - 10:30 Phase III vaccine trials: methodology and implementation Audino PODDA

(GSK Vaccines Institute for Global Health) 10:30 - 11:00 Coffee break 11:00 - 12:30 Finding correlates of protection or the “Holy Grail” Mark FLETCHER to avoiding large phase III clinical trials (Pfizer, France) 12:30 - 14:00 Lunch 14:00 - 15:30 Antigen discovery: from genomics to proteomics Guido GRANDI (University of Trento, Italy) 15:30 - 16:00 Coffee break 16:00 - 18:00 Anti-cancer vaccines: dream or reality? Guido GRANDI (University of Trento, Italy)

THURSDAY FEBRUARY 22 9:00 - 10:30 Preparation Workshop Malaria Vaccine Design Malaria: epidemiology, physiopathology, Zarifah REED immune responses (Vac-4-All SAS, France) 10:30 - 11:00 Coffee break 11:00 - 12:30 Preparation Workshop Malaria Vaccine Design Progress in malaria vaccine development Chetan CHITNIS (Institut Pasteur, France) 12:30 - 14:00 Lunch 14:00 - 15:30 Discussion Z. REED/ C. CHITNIS (Institut Pasteur, France) 15:30 - 16:00 Coffee break 16:00 - 17:30 Summary of the critical steps in Cécile ARTAUD early phase vaccine development (Institut Pasteur, France)

MODULE III: UPDATE OF VACCINE DEVELOPMENT FOR THE MAJOR INFECTIOUS DISEASES

FRIDAY, FEBRUARY 23

THE EXAMPLE OF NEW VACCINES MADE RECENTLY AVAILABLE 9:00 - 10:30 Rotavirus vaccines: success and drawback Timo VESIKARI (University of Tampere, Finland) 10:30 - 11:00 Coffee break 11:00 - 12:30 The success of the glycoconjugate vaccines Michel BEURRET (Janssen, The Netherlands) 12:30 - 14:00 Lunch 14:00 - 15:30 HPV: a vaccine against virus-induced cancer Mark DOHERTY (GSK Biologicals, Belgium) 15:30 - 16:00 Coffee break 16:00 - 17:30 Sharing experience session: Lessons from vaccine success-stories? (T. Vesikari, M. Beurret, M. Doherty, B. Combadière, A. Phalipon) MONDAY, FEBRUARY 26

ACUTE RESPIRATORY INFECTIONS 9:00 - 10:30 Influenza viruses Sandie MUNIER (Institut Pasteur, Paris) 10:30 - 11:00 Coffee break 11:00 - 12:30 Influenza vaccines: the challenge of making Othmar ENGELHARDT a new vaccine each year and developing a universal vaccine (NIBSC, UK) 12:30 - 14:00 Lunch 14:00 - 15:30 Challenges for development of vaccines against Ruth KARRON respiratory diseases: the example of RSV (Johns Hopkins University, USA)

Sharing experience session: The development of vaccines against respiratory viruses (S. Munier, O. Engelhardt, R. Karron, A. Phalipon and B. Combadière)

15:30 - 16:00 Coffee break 16:00 – 16:30 Summary of the critical steps Christiane GERKE in early phase vaccine development (Institut Pasteur, Paris) 16:30 - 18:00 Preparation Workshop Malaria Vaccine Design Armelle PHALIPON Béhazine COMBADIERE

TUESDAY FEBRUARY 27

MAJOR POVERTY-ASSOCIATED INFECTIOUS DISEASES 9:00 - 11:00 Tuberculosis: Epidemiology, Diagnosis Steffen STENGER and Immune Responses (IMMH, Germany) 11:00 - 11:30 Coffee break 11:30 - 13:00 BCG, new TB vaccines, and biomarkers for vaccine trials Hazel DOCKRELL (London school of Hygiene and Tropical Medicine, London) 13:00 - 14:00 Lunch 14:00 - 15:00 Sharing experience session: Will it be possible to do better than BCG? (S. Stenger, H. Dockrell, B. Combadière, A. Phalipon) 15:00 - 15:30 Coffee break 15:30 - 17:00 New Public/Philanthropic Private Partnerships Jean LANG for Effective Global Health Vaccines Development (Sanofi-Pasteur, France) WEDNESDAY, FEBRUARY 28 9:00 - 10:30 Arboviruses: threats for human and hopes for vaccines Vincent DEUBEL (Consultant, France) 10:30 - 11:00 Coffee break 11:00 - 12:30 Dengue: epidemiology, physiopathology, immune Bruno GUY response, vaccine development (Consultant, France) 12:30 - 14:00 Lunch 14:00 - 16:00 Towards an AIDS vaccine? Brigitte AUTRAN (Hôpital Pitié-Salpêtrière, France) 16:00 - 16:30 Coffee break 16:30 – 18:00 Preparation Workshop Malaria Vaccine Design Armelle PHALIPON Béhazine COMBADIERE

THURSDAY, MARCH 1 9:00 - 10:30 The Burden of Diarrheal Diseases and Duncan STEELE Prospects for Vaccine Impact (Gates Foundation, USA) 10:30 - 11:00 Coffee break 11:00 - 12:30 Microbiota and vaccine effectiveness William PETRI (University of Virginia, USA) 12:30 - 14:00 Lunch 14:00 - 15:00 Sharing experience session: Next steps in enteric vaccine development? (D. Steele, W. Petri, B. Combadière, A. Phalipon) 15:00 - 15:30 Coffee break 15:30 - 17:30 Preparation Workshop Malaria Vaccine Design Armelle PHALIPON Béhazine COMBADIERE FRIDAY, MARCH 2 9:00 - 12:30 Workshop Malaria vaccine design Armelle PHALIPON

Béhazine COMBADIERE Nathalie DEBARD Expert Committee: Zarifah REED, Odile LEROY, Chetan CHITNIS, Pierre DRUILHE, Rogerio AMINO 12:30 - 14:00 Lunch 14:00 - 17:00 Workshop (continued)

MODULE IV: FUTURE CHALLENGES

MONDAY, MARCH 5 9:00 - 10:30 Globalization of vaccine production Joël CALMET (Sanofi Pasteur, France) 10:30 - 11:00 Coffee break 11:00 - 12:30 The long and winding road to make vaccines Souleymane KONE accessible to the population in need: (WHO, Switzerland) an infrastructure issue 12:30 - 14:00 Lunch 14:00 - 15:30 The long and winding road to make vaccines accessible Deborah ATHERLY to the population in need: an economical issue (PATH, USA) 15:30 - 16:00 Coffee break 16:00 - 17:30 Preventing diarrheal diseases, a complex issue Philippe SANSONETTI (Institut Pasteur, Paris) TUESDAY, MARCH 6 9:00 - 10:30 What are the issues vaccine manufacturers Rino RAPPUOLI take into account for go/no go in developing (GSK, Italy) a new vaccine 10:30 - 11:00 Coffee break 11:00 - 12:30 Aging population and vaccination Richard ASPINALL (Anglia Ruskin University) 12:30 - 14:00 Lunch 14:00 - 15:30 Sharing experience session What will be the next vaccines? R. Rappuoli, R. Aspinall, B. Combadière, A. Phalipon) Free for exam preparation

WEDNESDAY, MARCH 7 9:00 – 11:00 Free for exam preparation 11:00 - 12:30 Of the importance of maintaining vaccine Daniel LEVY-BRUHL coverage: the example of measles (Santé Publique France, France) 12:30 - 14:00 Lunch 14:00 – 15:30 Vaccine hesitancy Angus THOMSON (Sanofi Pasteur, France) Free for exam preparation THURSDAY, MARCH 8 11:00 - 12:00 Written examination 12:00 - 14:00 Lunch 14:00 - 15:30 Visit of the Institut Pasteur Museum 15:30 - 17:00 Closing lecture “Vaccines for public health emergencies” Marie-Paule KIENY (Inserm, France) FRIDAY, MARCH 9 10:00 - 12:00 Feedback exam / Visit of laboratories Armelle PHALIPON Béhazine COMBADIERE 12:00 - 14:00 Closing party

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CONTACTS - INSTITUT PASTEUR Directors Armelle PHALIPON Unité de Pathogénie Microbienne Moléculaire Institut Pasteur, Paris Tel : +33 (0) 1 40 61 32 46 armelle.phalipon@pasteur.fr Béhazine COMBADIERE Centre d'Immunologie et des Maladies infectieuses Cimi-Paris Head team 5: "Immunity and Vaccination" 91 boulevard de l'hôpital 75013 PARIS - France TEL:+33140779888 FAX:+33140779734 behazine.combadiere@upmc.fr Education center –28 rue du Docteur Roux side Sylvie GARNERO Building 09C - Pavillon Louis Martin – 1st floor Tél : +33 (0)1 40 61 38 04 Email : sgarnero@pasteur.fr cours@pasteur.fr Registrar's Office Sylvie MALOT Céline CORBIN (Assistant) Tel : +33 (0) 1 40 61 33 62 Building 13 - Room Saint-Joseph de Cluny Email : enseignement@pasteur.fr