Assembling the Infrastructure to Support

Global DecisionSite Deployment

Deborah Jones-HertzogSite Head, Cheminformatics

Agenda• Introduction• Challenges

– Building the infrastructure– Coordinating IT organizations– Managing client needs/expectations– Funding

• Case Study• Acknowledgements

Environment• Desktop

– Team Connect at former SmithKline Beecham– GWSD at former Glaxo Wellcome– Standard NT 4.0 install (rare)

• Data center– NT 4.0 Server– Solaris 7.0 standard, 8.0 in approval– Oracle 8.1.7 standard

Spotfire EnhancementDecember 2000Spotfire.Net

April 2001DecisionSite

ApacheResin

BEA WeblogicServer

Spotfire DecisionSite ArchitectureIISDecisionSites:

Lead DiscoveryFunctional GenomicsStatisticsHTS QC - customMCCD - custom

Oracle

Internet

WebDB

Sybase

Stakeholder Groups

• Cheminformatics• Bioinformatics• Discovery IT• Research Data

Management• SCS

– Global Services– Unix Engineering– Database Administration

IT• Centers for Excellence in

Drug Discovery• High Throughput Screening• High Throughput Chemistry• High Throughput Biology• Systems Research• Genomics• DMPK

Client

Architectural Decisions• Server Platform

– NT– Solaris

• Single or multiple servers– Cost– Geographic needs– Redundancy– WAN capacity

• Spotfire version - 6.2 or 7.0?– 7.0 has enhanced client requirements– 7.0 has improved functionality and enhanced API

Building Infrastructure• Client• Server

– Latency and stress testing– Reliability– Data access– Cost

• Support models– Software support– Scientific support– Training

Server• Latency and stress testing

– Evaluate what traffic can be sustained by a single DecisionSite server

– Network engineers reluctant to allow testing at this time

• Reliability requirements– Worldwide organization– 24x7 environment for some applications– Not yet proven in practice

Server• Data Access

– Centralized administration and access• Account control through LDAP• Central repository for queries• Data processing and analysis controlled through

centrally located guides– Distributed data mart access

• Locally stored information– Day to day work– Generally needed information

• Global information– Retrieval with analogous process as local data– Normalized, cleaned data provided by data marts

Building a Support Model• Global integrated help desk

– Merging legacy support groups impacted development of a support model

• Training program needed.– End user training (web based and classroom)– Help desk support– Second level support– Developer support

• FAQs and knowledgebase

Department Interactions OverviewIT Research

Cheminformatics

Bioinformatics

R&DCEDDs

High Throughput Screening

High Throughput Chemistry

High Throughput Biology

Systems Research

DMPK

SCSGlobal Services

Unix Engineering

Database Administration

Discovery IT

Pre-clinical IT

Managing Client Needs• Desires

– Rapid development– Rapid deployment– Immediate support– Interactive solution refinement

• Software development is often not understood. Demonstration means that it must be ready.

• A history of poor rollouts by the software industry has created a generally negative perception of software releases.

GlaxoSmithKline Deployment• Current Status

– Production hardware in deployment– Desktop environment tested– Training program in development– Support agreements completed

• Go Live:– Q2, 2002– Staged worldwide rollout

Final Spotfire Architecture

UPUM

RTP

STVHLW

TC Verona

TRL

Les Ulis

System Statistics• DecisionSite 7.0• Servers: Sun Solaris 8

– 3 Enterprise 6800– 1 Enterprise 10,000 (2 domains)– Test and Production Domains

• Pilot domains run by Cheminformatics for rapid development and small group projects

– Upper Merion, Stevenage, RTP– Both NT and Solaris 8

Issues along the way…

• Spotfire project accelerated definition of many processes being redesigned post merger

– New server hardware– New Helpdesk structure– New application integration process for legacy desktops– New IT review and Finance processes

• Definition of DecisionSite version for a sustainable enterprise system.

– Once it is delivered to the enterprise changes (upgrades?) are expensive.

– Can we validate for GLP/GMP?

Issues along the way…• Users excited about new functionality before infrastructure

is in place– Pilot groups communicate to others– How to not squash enthusiasm while moving a large

organization to the needed infrastructure?• Managers are excited about process control opportunities

afforded by guides– Significant opportunity for process improvement– Usual triage required for application development needs

Thank you• Spotfire

– Jeff Molloy– Cristian Ilie– Gail Currie– Amish Shah– Joyce Huffman– Trish Ward– Simon Eckford

• GSK– Fran Stewart– Terry Francis– Chris Louer– John Kochins– Paul Konstant– Richard Bolton– Dana Vanderwall– Deborah Jones-

Hertzog– Jeff Wiseman

–Manuel Valmaseda

–Kate Harvey

–Roger Martin

–Phil Rossini

–Lisa VonCzoernig

–Michael Moore

–Ricardo Macarron

–Tony Jurewicz