ASID May 2018 ieQ: ESTABLISHMENT OF AUSTRALIA’S · Infective Endocarditis Queensland [ieQ],...
Transcript of ASID May 2018 ieQ: ESTABLISHMENT OF AUSTRALIA’S · Infective Endocarditis Queensland [ieQ],...
ieQ: ESTABLISHMENT OF AUSTRALIA’S
FIRST INFECTIVE ENDOCARDITIS
REGISTRY AND BIO.BANK.
Enquiries: Dr Robert Horvath MBBS FRACP FRCPA
Infectious Diseases Physician and Clinical Microbiologist
Infection Management Services; The Prince Charles Hospital
Department of Health | Queensland Government
Rode Rd. Chermside 4032 t. 07 [31394111]
e. [email protected] | www.health.qld.gov.au
Registry & Surveillance
ASID May 2018
The Prince
Charles Hospital
Robert Horvath1,2,4,5, John F Sedgwick1,4,5, Yong S Wee1,4,5, Joseph C Lee3,4,5, David B Godbolt2,5 and Anne Cameron1,4,5 on behalf of the ieQ Collaborative.
1. Internal Medicine, The Prince Charles Hospital, Brisbane, Queensland, Australia; 2. Pathology Queensland, Brisbane, Australia 3. Medical Imaging Department, The Prince
Charles Hospital, Brisbane, Queensland, Australia; 4. Faculty of Medicine, The University of Queensland, Australia 5. infective endocarditis Queensland [ieQ], The Prince
Charles Hospital, Queensland, Australia. Funded by the Metro North Hospital and Health Service SEED Innovation Program 2016/17
Acknowledgements: This initiative would not be possible without the support of a great number of
people who have generously given of their time, experience and support. We
sincerely thank [in no particular order]: Claire Harrison and the MNHHS SEED
Innovation Program, Mary Lazo and Jon Fraser [Metro North IT], TPCH Infection
Management Services, Glen Lawrence and Christine Crowley [TPCH Pathology],
the TPCH Ethics Team and Committee, Brooke Chadwick [IMS Business
Manager], Rhonda Mead [Nursing Director, IMS], Elizabeth Clark [Pathology
Queensland] and most importantly, our patients. Thank you.
Introduction
Infective Endocarditis Queensland [ieQ], founded in 2017 and based at The Prince
Charles Hospital [TPCH], is a multidisciplinary collaborative of health professionals
and academics established to support research, clinical care and outcomes of people
with infective endocarditis.
Methods
ieQ has conceived a Bio.Bank for long-term storage of blood, tissue and microbes
referenced to a Registry of patient demographics, outcomes, treatment and discipline-
specific data of interest e.g. echocardiography, antibiotic therapy and health service
utilisation. Establishment of the initiative was facilitated by a grant from the
Queensland Health Metro North SEED Innovation Fund.
The Registry and Bio.bank have received institutional ethics approval, with patients to
be offered inclusion via informed consent.
A core feature of the Registry is its design that was developed in partnership with
Queensland Health Metro North Information Technology, and which is a live and on-
line database. This database includes clinical, pathology and imaging features, and is
enabled to collate data from affiliated platforms [admission data] in addition to direct
data entry. The long term future forecast is for the database to ‘link’ with additional data
cohorts.
Results
The first 12 months have seen the consolidation of an ethical framework; development
of a collaborative structure and key administration guidelines; purchase, installation
and custodianship of Bio.bank freezer within Pathology Queensland auspices; and the
development and deployment of the Registry platform.
The collaborative is positioned to commence patient recruitment in mid 2018.
Secondary outcomes to date:
▪ Supported collaborative and interdisciplinary engagement with regular IE Working
Group meetings, inclusive of all of Metro North HHS, public and private pathology
services, and academic institutions.
▪ Formulation of multi-disciplinary Endocarditis Advisory Team “EAT”, initially TPCH-
centric with a long-term aim to provide support statewide.
▪ [In development] A University of Queensland sponsored Website with patient and
practitioner information and a portal for national and international links.
▪ Supported collaboration and translation of research outcomes:
International Symposium on Modern Concepts in Endocarditis and
Cardiovascular Infections; June 22-24 [Dublin]. 6 abstracts accepted posters
Cardiac Society of Australia and New Zealand; Aug 2017 [Perth]. 1 abstract.
The Prince Charles Symposium; Oct 2017. 2 abstracts accepted
Infectious Diseases Society of America; Oct 2017 [San Diego]. 1 abstract
accepted
Cardiac Society of Australia and New Zealand; August 2018 [Brisbane];
abstract in review
Disclosure of Interest Statement: ieQ is funded by in-kind support of Queensland
Health and a grant from the Queensland Health Metro North SEED Innovation Fund.
No pharmaceutical grants were received in the development of this study.
ieQ Management
Committee
Research Translation Education
and
capacity
building
Patient
support Clinical
advisory
group
ieQ Expert
Working Group
▪ Registry
and
Bio.bank
▪ “EAT”
TPCH
Expert
advisory
Team
▪ Information
sheets
▪ Videos
▪ Website
▪ Conferences
▪ Publications
▪ Grand
rounds
▪ Networking
eg Primary
Health
▪ Advanced
trainees
▪ Statewide
support
▪ S.lugdunensis
▪ Q fever
▪ HACEK
▪ Candida
▪ Other
Collaborative
framework:
state, national and
international
ieQ
Collaborative
structure Administration
Patient/Consumer
representative
Conclusion
A quality Infective Endocarditis Registry and Bio.bank is a pre-requisite for the
clinically-critical work of improving diagnosis, management and patient outcomes of
individuals affected by Infective Endocarditis.
Under a clinical and research framework, ieQ aims to improve understanding,
in an Australian context, of this disease.