ARTHRITIS
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Transcript of ARTHRITIS
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ARTHRITIS
Rheumatoid ArthritisPresented By:
Ali Raza Ansar
Qudsia Sehar
Hafsa Kabir
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Introduction • Joint disorder that cause inflammation• Over 100 types of Arthritis• Most Common is Rheumatoid Arthritis and
osteoarthritis, both are autoimmune diseases.
Symptoms– Inability to use the hand or walk– Malaise and a feeling of tiredness–Weight loss– Poor sleep–Muscle aches and pains– Tenderness– Difficulty moving the joint
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Biology Of Rheumatoid Arthritis
1. Genetic Basis of RA:–HLA genes: HLA-DR1 and DR4 are
associated with disease–PDAI: Peptidyl arginine deaminase gene–PTN22 gene: Regulates kinases
2. Autoantibodies:–Rh factor: Antibody, binds to the Fc region
of IgG.
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–ACPA: Anti-citrullinated protein antibody, MHC class-II, specially bearing “shared epitope” bind efficiently with citrullinated proteins. An immune response is triggered producing ACPA.
3. Inflammation and bone deformity:–Different cytokines are involved–IL-1, IL-6 and TNFα are important–Normal bone remodeling
• Osteoblasts • Osteoclasts
–NF-κB plays significant role in RA pathogenesi–Role of estrogen
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Diagnosis of Arthritis
Diagnostic Tools 1. Physical Examination
2. Laboratory Tests
3. Medical Imaging
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Laboratory Tests
• Rheumatoid factor• Erythrocyte sedimentation Rate• C-reactive protein• Anti-cylic citullinated Peptide Antibody Test• Antinuclear Antibodies• Compete blood count
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Treatment
• Drug treatment• Occupational/physical therapy• Surgery• Biologics
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Drug Treatment
• Pain killers • NSAID’S (non-steroidal anti inflammatory
drug)• Cox-2 inhibitors• Gold injections
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• Physical therapy
• Surgery
Performed when patients are non-responsive for treatment
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Biotechnological Applications in Treatment
• Biologics– Use specifically for rheumatoid arthritis– Target specific• Act only on immune system
– Anti- t.f is an example
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Current Research Projects
• DEVELOPMENT OF ANTISENSE THERAPY OF ARTHRITIS
• DEVELOPMENT OF A BIOMARKER FOR RA
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Development of Antisense Therapy of Arthritis
• Developed by BGN technologies
• Target cPLA-2
• Inhibits the synthesis of c-PLA 2 ENZYME
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Development of a Biomarker For RA
• RA biomarker based on 14-3-3η protein
• It is an intracellular protein
• Suffering from RA it is involved in joints deformation and is released inside joints
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QUESTIONS