Sulfamethoxazole-induced sulfamethoxazole urolithiasis: a ...
Aromatic Hydrocarbons 1Sulfanilamide (A) H2N H2N NI-12 V/ NH2 Metabolism .HCI Prontosil Cl-13...
Transcript of Aromatic Hydrocarbons 1Sulfanilamide (A) H2N H2N NI-12 V/ NH2 Metabolism .HCI Prontosil Cl-13...
Organic Chemistry II 1st Semester, Year 2 (2018-2019) Lecture 1
Aromatic Hydrocarbons 1 Dr Asim A. Balakit Pharmaceutical Chemistry Dept., College of Pharmacy, Babylon University
This lecture is mainly based on: Pharmaceutical Chemistry Edited by Jill Barber & Chris Rostron, Oxford University Press, 2013
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What is aromatic chemistry?!
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To be considered aromatic a compound must:
1- be planar (or close to planar)
2- have 4n+2 π-electrons; this criterion is known as Huckel’s rule
3- be cyclic and fully conjugated
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Why is aromatic chemistry important?!
Prontosil and the sulfa drugs:
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Aspirin
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Prozac and Viagra
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Illegal Drugs: Ecstasy and cannabis
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The chemistry of benzene Electrophilic aromatic substitution:
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The mechanism
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Specific electrophilic aromatic substitution reactions: Nitration
Sulfonation
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Friedel-Crafts reaction – the formation of carbon-carbon bonds: Friedel-Crafts acylation
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Friedel-Crafts alkylation
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To solve the problem:
The next lecture will be about the electrophilic aromatic substitution of substituted benzenes- directing effects.
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