Appendix 1 - Cinecadspace-unipr.cineca.it/bitstream/1889/2452/4/APPENDIX1_domains.pdfAppendix 1...

A1

Appendix 1

Bacterial LOV domains

Underlined: species/strain also possessing BLUF domains‐ In gray: species/strains present in first analysis (2012).

Nr. Species/strain Group Accession nr. Uniprot Accession nr. NCBI aa nr. Domains Prot. Nr. 1 Amphibacillus jilinensis F WP_017473228.1 262 LOV+STAS 1 2 Aneurinibacillus aneurinilyticus F WP_021620417.1 491 PAS+LOV+SPOIIE 2 3 Bacillus amyloliquefaciens F WP_017418405.1 276 LOV+STAS 3

Bacillus amyloliquefaciens ATCC 23350 F E1UNE3 YP_003921412.1 261 LOV+STAS 4 Bacillus amyloliquefaciens CAU-B946 F H2ABK8 YP_005131472.1 261 LOV+STAS 5 Bacillus amyloliquefaciens FZB42 F A7Z7V9 YP_001422316.1 261 LOV+STAS 6

4 Bacillus amyloliquefaciens subsp. plantarum AS43.3 F L0BRW8 YP_007187501.1 261 LOV+STAS 7 Bacillus amyloliquefaciens subsp. plantarum NAU-B3 F CDH96675.1 261 LOV+STAS 8 Bacillus amyloliquefaciens subsp. plantarum UCMB5033 F S6G2H0 YP_008413843.1 276 LOV+STAS 9 Bacillus amyloliquefaciens subsp. plantarum UCMB5036 F M1XEM3 YP_007498348.1 261 LOV+STAS 10 Bacillus amyloliquefaciens subsp. plantarum UCMB5113 F S6FTN1 YP_008422089.1 276 LOV+STAS 11 Bacillus amyloliquefaciens subsp. plantarum YAU B9601-Y2 F H8XFK1 YP_005422280.1 276 LOV+STAS 12 Bacillus amyloliquefaciens TA208 F F4E8V5 YP_005542621.1/YP_003921412.1 261 LOV+STAS 13 Bacillus amyloliquefaciens XH7 F G0IGZ5 YP_005551014.1/YP_003921412.1 261 LOV+STAS 14 Bacillus amyloliquefaciens (Bacillus velezensis) F F4EJR7 YP_005546869.1/YP_003921412.1 261 LOV+STAS 15

5 Bacillus atrophaeus F R0MMM0 WP_010789563.1 273 LOV+STAS 16 Bacillus atrophaeus str. 1942 F E3E2E8 YP_003974446.1 263 LOV+STAS 17

6 Bacillus endophyticus F WP_019392897.1 259 LOV+STAS 18 7 Bacillus macauensis ZFHKF-1 F I8AIW7 WP_007201639.1 263 LOV+STAS 19 8 Bacillus megaterium F WP_016764751.1 260 LOV+STAS 20

Bacillus megaterium ATCC 12872 F D5DX18 YP_003563516.1 260 LOV+STAS 21 Bacillus megaterium DSM 319 F D5DGT4 YP_003598275.1 214 LOV+STAS 22 Bacillus megaterium WSH-002 F G2RIW6 YP_005494307.1 260 LOV+STAS 23

9 Bacillus mojavensis F WP_010331556.1 261 LOV+STAS 24 10 Bacillus pumilus F WP_019743696.1 267 LOV+STAS 25

WP_017367889.1 267 LOV+STAS 26 WP_019743575.1 262 LOV+STAS 27 WP_017368190.1 262 LOV+STAS 28 Bacillus pumilus ATCC 7061 F B4ANP6 WP_003217570.1 267 LOV+STAS 29 B4AJ24 WP_003214834.1/YP_001488493.1 262 LOV+STAS 30 Bacillus pumilus SAFR-032 F A8FGG2 YP_001487889.1 267 LOV+STAS 31 A8FI66 YP_001488493.1 262 LOV+STAS 32 11 Bacillus selenitireducens ATCC 700615 F D6XXH5 YP_003698598.1 256 LOV+STAS 33 12 Bacillus siamensis F WP_016938511.1 261 LOV+STAS 34 13 Bacillus sp. 5B6 F I2HUE6 WP_007613218.1 261 LOV+STAS 35 14 Bacillus sp. HYC-10 F K2NQI4 WP_008354841.1 262 LOV+STAS 36

A2

K2NB57 WP_008356458.1 279 LOV+STAS 37 15 Bacillus sp. JS F I0F7W3 YP_006232825.1 261 LOV+STAS 38 16 Bacillus sp. M 2-6 F I4VFF5 WP_008343003.1 267 LOV+STAS 39

I4VEQ1 WP_008343295.1 262 LOV+STAS 40 17 Bacillus stratosphericus LAMA 585 F M5RFF6 WP_007501884.1 267 LOV+STAS 41

M5R3V3 WP_007497556.1 262 LOV+STAS 42 18 Bacillus subtilis F WP_019259236.1 261 LOV+STAS 43

WP_019715441.1 261 LOV+STAS 44 Bacillus subtilis BSn5 F E8VHV4 YP_004204857.1 261 LOV+STAS 45 19 Bacillus subtilis subsp. inaquosorum KCTC 13429 F L8Q4F3 WP_003238003.1 261 LOV+STAS 46 20 Bacillus subtilis subsp. natto BEST195 F D4G0B4 YP_005562248.1 261 LOV+STAS 47 21 Bacillus subtilis subsp. spizizenii ATCC 23059 F E0TXF2 YP_003867287.1 261 LOV+STAS 48

Bacillus subtilis subsp. spizizenii ATCC 6633 F D5N263 WP_003223298.1/YP_003867287.1 261 LOV+STAS 49 Bacillus subtilis subsp. spizizenii TU-B-10 F G4NZQ8 YP_004878519.1 261 LOV+STAS 50 22 Bacillus subtilis subsp. subtilis RO-NN-1 F G4P3K6 YP_005558004.1 261 LOV+STAS 51

Bacillus subtilis subsp. subtilis str. 168 F O34627-YtvA NP_390912.1 261 LOV+STAS 52 Bacillus subtilis subsp. subtilis str. BSP1 F L0D031 YP_007208463.1 261 LOV+STAS 53 Bacillus subtilis subsp. subtilis str. SC-8 F G4ES72 WP_003229169.1 261 LOV+STAS 54 Bacillus subtilis XF-1 F M4KWC9 YP_007427967.1 261 LOV+STAS 55 23 Bacillus vallismortis F WP_010329536.1 261 LOV+STAS 56 24 Bhargavaea cecembensis DSE10 F M7NUV9 WP_008300509.1 259 LOV+STAS 57 25 Clostridium tyrobutyricum F WP_017750870.1 666 PAS+LOV+PAS+Kinase+RR 58 26 Halobacillus halophilus ATCC 35676 F I0JHP4 YP_006178939.1 266 LOV+STAS 59 27 Halobacillus sp. BAB-2008 F L5N866 WP_008636934.1 268 LOV+STAS 60 28 Listeria grayi DSM 20601 F D7UXG5 WP_003758096.1 257 LOV+STAS 61 29 Listeria innocua ATCC 33091 F H1GBU2 WP_003770995.1 266 LOV+STAS 62

Listeria innocua Clip11262 F Q92DM1 NP_470134.1 253 LOV+STAS 63 Listeria innocua FSL J1-023 F E3Z5Q4 WP_003765959.1 253 LOV+STAS 64 Listeria innocua FSL S4-378 F E3YX19 WP_003761128.1/NP_470134.1 253 LOV+STAS 65 30 Listeria ivanovii ATCC BAA-678 F G2ZDA1 YP_004854533.1 253 LOV+STAS 66 31 Listeria marthii FSL S4-120 F E3YNA7 WP_008947200.1 253 LOV+STAS 67 32 Listeria monocytogenes F L8DRI2 NP_464326.1 253 LOV+STAS 68

Listeria monocytogenes 07PF0776 F I0CPV0 YP_013419.1 253 LOV+STAS 69 Listeria monocytogenes 10403S F G2K4H2 YP_005961931.1/NP_464326.1 253 LOV+STAS 70 Listeria monocytogenes 4b H7858 F Q4EEF6 WP_003726661.1/YP_013419.1 253 LOV+STAS 71 Listeria monocytogenes ATCC 19117 F J7PNH7 YP_013419.1 253 LOV+STAS 72 Listeria monocytogenes EGD-e F P58724 NP_464326.1 253 LOV+STAS 73 Listeria monocytogenes F2365 F Q722B8 YP_013419.1 253 LOV+STAS 74 Listeria monocytogenes F6854 F Q4EN15 EAL05103.1/NP_464326.1 253 LOV+STAS 75 Listeria monocytogenes F6900 F C8KA37 EEW21003.1/NP_464326.1 253 LOV+STAS 76 Listeria monocytogenes Finland 1998 F G2KIU9 YP_005970621.1/NP_464326.1 253 LOV+STAS 77 Listeria monocytogenes FSL F2-208 F E3YE39 WP_003735967.1 253 LOV+STAS 78 Listeria monocytogenes FSL J1-194 F D4PI54 WP_003726937.1/YP_013419.1 253 LOV+STAS 79 Listeria monocytogenes FSL J1-208 F H7CIX6 WP_003738433.1 253 LOV+STAS 80 Listeria monocytogenes FSL J2-071 F D3KP16 EFD90245.1/YP_002350789.1 253 LOV+STAS 81 Listeria monocytogenes FSL N1-017 F D7UJQ9 EFK41291.1/YP_013419.1 253 LOV+STAS 82 Listeria monocytogenes FSL N3-165 F C8JWU1 EEW14621.1/NP_464326.1 253 LOV+STAS 83 Listeria monocytogenes FSL R2-503 F C8K567 EEW19771.1/YP_013419.1 253 LOV+STAS 84 Listeria monocytogenes FSL R2-561 F G2K6K4 YP_005967717.1/NP_464326.1 253 LOV+STAS 85 Listeria monocytogenes HPB2262 F D4Q0W9 EFF94760.1/YP_013419.1 253 LOV+STAS 86

A3

Listeria monocytogenes J0161 F G2JVW6 YP_005964793.1/NP_464326.1 253 LOV+STAS 87 Listeria monocytogenes J1-220 F F3RIF4 YP_008289002.1/YP_013419.1 253 LOV+STAS 88 Listeria monocytogenes J1816 F F3RC23 YP_008285930.1/YP_013419.1 253 LOV+STAS 89 Listeria monocytogenes J2818 F D4PRY3 EFF97759.1/NP_464326.1 253 LOV+STAS 90 Listeria monocytogenes L312 F J7P482 YP_013419.1 253 LOV+STAS 91 Listeria monocytogenes N53-1 F L8E287 NP_464326.1 253 LOV+STAS 92 33 Listeria monocytogenes serotype 1/2a 08-5578 F D2P049 YP_003412995.1/NP_464326.1 253 LOV+STAS 93

Listeria monocytogenes serotype 1/2a 08-5923 F D2PB38 YP_003416040.1/NP_464326.1 253 LOV+STAS 94 34 Listeria monocytogenes serotype 4a HCC23 F B8DGG7 YP_002350789.1 253 LOV+STAS 95

Listeria monocytogenes serotype 4a M7 F F8BE06 YP_005946888.1/YP_002350789.1 253 LOV+STAS 96 35 Listeria monocytogenes serotype 4b Clip81459 F C1L168 YP_002757524.1/YP_013419.1 252 LOV+STAS 97

Listeria monocytogenes serotype 4b str. LL195 F K8FAX5 YP_007014391.1 302 LOV+STAS 98 36 Listeria monocytogenes serotype 4c L99 F E1UEF6 YP_005925797.1/YP_002350789.1 253 LOV+STAS 99 37 Listeria monocytogenes serotype 7 str. SLCC2482 F J7MIR4 YP_013419.1 253 LOV+STAS 100

Listeria monocytogenes SLCC2372 F J7NJ10 NP_464326.1 253 LOV+STAS 101 Listeria monocytogenes SLCC2376 F J7P7Y6 YP_002350789.1 253 LOV+STAS 102 Listeria monocytogenes SLCC2378 F J7P7K7 YP_013419.1 253 LOV+STAS 103 Listeria monocytogenes SLCC2479 F J7N224 NP_464326.1 253 LOV+STAS 104 Listeria monocytogenes SLCC2540 F J7PFP1 YP_013419.1 253 LOV+STAS 105 Listeria monocytogenes SLCC2755 F J7N0R0 YP_013419.1 253 LOV+STAS 106 Listeria monocytogenes SLCC5850 F J7MN47 NP_464326.1 253 LOV+STAS 107 Listeria monocytogenes SLCC7179 F J7NYX0 NP_464326.1 253 LOV+STAS 108 Listeria monocytogenes str. Scott A F F3YSH3 EGJ24299.1/YP_013419.1 253 LOV+STAS 109 38 Listeria seeligeri FSL N1-067 F E3ZND1 WP_003746290.1 266 LOV+STAS 110

Listeria seeligeri FSL S4-171 F E3ZX98 WP_003751585.1 253 LOV+STAS 111 39 Listeria seeligeri serovar 1/2b ATCC 35967 F D3UL64 YP_003463935.1 253 LOV+STAS 112 40 Listeria welshimeri serovar 6b str. SLCC5334 F A0AGP3 YP_848958.1 253 LOV+STAS 113 41 Oceanobacillus iheyensis HTE831 F Q8ESN8 NP_691509.1 264 LOV+STAS 114 42 Oceanobacillus kimchii F WP_017795669.1 264 LOV+STAS 115 43 Paenibacillus fonticola F WP_019637272.1 580 LOV+GGDEF+EAL 116 44 Paenibacillus polymyxa (strain E681) F E0REH5 YP_003868921.1 825 GAF+LOV+LOV+SPOIIE 117 45 Paenibacillus sp. A9 F WP_017813224.1 548 PAS+LOV+Kinase 118 46 Paenibacillus sp. PAMC 26794 F WP_017687351.1 382 LOV+Kinase 119 47 Paenibacillus terrae (strain HPL-003) F G7W1W6 YP_005074888.1 367 LOV+Kinase 120 48 Paenisporosarcina sp. TG-14 F WP_017381979.1 730 LOV+GAF+GGDEF+EAL 121 49 Paenisporosarcina sp. TG20 F WP_019413525.1 735 LOV+GAF+GGDEF+EAL 122 50 Planococcus antarcticus DSM 14505 F I4X763 WP_006829023.1 280 LOV+STAS 123 51 Planococcus donghaensis MPA1U2 F E7RG70 WP_008430240.1 282 LOV+STAS 124 52 Planococcus halocryophilus Or1 F M3F5S5 WP_008498406.1 292 LOV+STAS 125 53 Saccharibacillus kuerlensis F WP_018975129.1 385 LOV+Kinase 126 54 Salimicrobium sp. MJ3 F K2GL47 WP_008591203.1 269 LOV+STAS 127 55 Virgibacillus halodenitrificans F WP_019378944.1 258 LOV+STAS 128 56 Virgibacillus sp. CM-4 F T0JJ18 WP_021291946.1 263 LOV+STAS 129 57 Actinomycetospora chiangmaiensis Ac WP_018335315.1 715 PAS+LOV+GAF+SPOIIE 130 58 Arthrobacter aurescens TC1 Ac A1RDS2 YP_950384.1 727 LOV+ GGDEF+EAL 131 59 Arthrobacter sp. TB 23 Ac WP_019481926.1 681 LOV+GGDEF+EAL 132 60 Beutenbergia cavernae DSM 12333 Ac C5BXY5 YP_002880641.1 580 LOV+GAF+SPOIIE 133 61 Blastococcus saxobsidens DD2 Ac H6RWC2 YP_005329368.1 762 LOV+GGDEF+EAL 134 62 Cellulomonas fimi DSM 20113 Ac F4H5H4 YP_004455284.1 594 PAS+LOV+SPOIIE 135 63 Cellulomonas flavigena DSM 20109 Ac D5UEA1 YP_003638776.1 570 LOV+GAF+SPOIIE 136

A4

64 Cellulomonas sp. JC225 Ac WP_019135604.1 564 LOV+GAF+SPOIIE 137 65 Frankia sp. BCU110501 Ac WP_018504846.1 664 LOV+GAF+SPOIIE 138 66 Frankia sp. CN3 Ac G6HCZ9 WP_007513898.1 603 LOV+GAF+SPOIIE 139 67 Frankia sp. str. Eul1c Ac E3J501 YP_004015322.1 628 LOV+GAF+SPOIIE 140 68 Geodermatophilus obscurus DSM 43160 Ac D2S7Y1 YP_003411932.1 760 PAS+LOV+GAF+SPOIIE 141 69 Kineococcus radiotolerans SRS30216 Ac A6WG47 YP_001364050.1 743 GGDEF+LOV+EAL 142

A6W4U8 YP_001360101.1 723 LOV+GAF+SPOIIE 143 A6W4X7 YP_001360130.1 408 LOV+SPOIIE 144 70 Leifsonia rubra CMS 76R Ac S7W0I9 WP_021809600.1 653 LOV+GGDEF+EAL 145 71 Modestobacter marinus BC501 Ac I4EZ22 YP_006367116.1 750 EAL+DICT+LOV+GGDEF 146

Modestobacter marinus BC502 Ac I4F5I6 YP_006369358.1 776 PAS+LOV+GAF+SPOIIE 147 72 Nakamurella multipartita DSM 44233 Ac C8XJT7 YP_003203637.1 365 PAS+RR+LOV 148

C8X922 YP_003204109.1 149 Short‐LOV 149 73 Rubrobacter radiotolerans Ac E9REA7 BAJ78459.1 85 Short‐LOV 150 74 Rubrobacter xylanophilus DSM 9941 Ac Q1ARZ9 YP_645641.1 581 LOV+GAF+SPOIIE 151 75 Agrobacterium albertimagni AOL15 P(α) K2Q1D4 WP_006728201.1 375 LOV+Kinase 152 76 Agrobacterium sp. 10MFCol1.1 P(α) WP_019566834.1 589 LOV+GGDEF+EAL 153 77 Agrobacterium sp. 224MFTsu3.1 P(α) WP_020010289.1 369 LOV+Kinase 154 78 Agrobacterium sp. H13-3 P(α) F0L3W1 YP_004278691.1 369 LOV+Kinase 155

F0LEX8 YP_004444410.1 589 LOV+GGDEF+EAL 156 79 Agrobacterium tumefaciens 5A P(α) H0HAA7 WP_003515223.1 369 LOV+Kinase 157

H0HGN3 WP_003518335.1 589 LOV+GGDEF+EAL 158 80 Agrobacterium vitis (strain S4 / ATCC BAA-846) P(α) B9K197 YP_002547361.1 411 LOV+ Kinase 159 81 Ahrensia sp. R2A130 P(α) E0MQF6 WP_009757882.1 325 LOV+Kinase 160 82 alpha proteobacterium JLT2015 P(α)Unc M2U2Y4 WP_008602941.1 345 LOV+Kinase 161 83 alpha proteobacterium L41A P(α)Unc WP_017504522.1 364 LOV+Kinase 162 84 alpha proteobacterium LLX12A P(α)Unc WP_017503590.1 200 Short‐LOV 163

WP_017502221.1 866 LOV+PAS+GAF+Kinase 164 85 Amorphus coralli P(α) WP_018698921.1 773 PAS+LOV+GGDEF+EAL 165 86 Asticcacaulis excentricus (strain ATCC 15261) P(α) E8RN55 YP_004087039.1 596 LOV+Kinase+RR 166 87 Aureimonas ureilytica P(α) WP_019998669.1 306 LOV+Kinase 167

WP_019997685.1 346 LOV+Kinase 168 WP_019995998.1 406 LOV+Kinase 169 88 Bradyrhizobium oligotrophicum S58 P(α) M4ZKM0 YP_007510402.1 534 LOV+Kinase+RR 170 89 Bradyrhizobium sp. BTAi1 P(α) A5EAE7 YP_001237047.1 534 LOV+Kinase+RR 171 90 Bradyrhizobium sp. ORS278 P(α) A4Z279 YP_001208470.1 534 LOV+Kinase+RR 172 91 Bradyrhizobium sp. ORS 285 P(α) H0RX89 WP_006611907.1 534 LOV+Kinase+RR 173

H0RX89 WP_006611907.1 534 LOV+Kinase+RR 174 92 Bradyrhizobium sp. ORS 375 P(α) H0SK82 WP_009029541.1 534 LOV+Kinase+RR 175 93 Bradyrhizobium sp. STM 3809 P(α) H0SYI7 WP_008961860.1 534 LOV+Kinase+RR 176 94 Brevundimonas sp. BAL3 P(α) B4WCV5 WP_008259253.1 878 LOV+PAS+GAF+Kinase+RR 177 95 Brucella abortus (strain 2308 A) P(α) C4IVN9 WP_006016110.1/WP_002970660.1 496 LOV+PAS+ Kinase 178

Brucella abortus (strain 2308) P(α) Q2YKK7 NP_541657.1 463 LOV+PAS+ Kinase 179 Brucella abortus 01-0065 P(α) S3WQE0 NP_541657.1 489 LOV+Kinase 180 Brucella abortus 01-0585 P(α) S3VF14 NP_541657.1 489 LOV+Kinase 181 Brucella abortus 01-0648 P(α) S3P9P5 NP_541657.1 489 LOV+Kinase 182 Brucella abortus 225/65 P(α) N7SDC2 NP_541657.1 489 LOV+Kinase 183 Brucella abortus 355/78 P(α) N7SLZ0 NP_541657.1 489 LOV+Kinase 184 Brucella abortus 544 P(α) N7SWJ8 NP_541657.1 489 LOV+Kinase 185

A5

Brucella abortus 600/64 P(α) N7RYR9 NP_541657.1 489 LOV+Kinase 186 Brucella abortus 63/130 P(α) N7SCI3 NP_541657.1 489 LOV+Kinase 187 Brucella abortus 63/138 P(α) N7TSI7 NP_541657.1 489 LOV+Kinase 188 Brucella abortus 63/144 P(α) N7TUX2 NP_541657.1 489 LOV+Kinase 189 Brucella abortus 63/168 P(α) N7U9C9 NP_541657.1 489 LOV+Kinase 190 Brucella abortus 63/294 P(α) N7TE92 WP_006091747.1 489 LOV+Kinase 191 Brucella abortus 63/59 P(α) N7A0H8 NP_541657.1 489 LOV+Kinase 192 Brucella abortus 64/108 P(α) N7TIY1 NP_541657.1 489 LOV+Kinase 193 Brucella abortus 64/122 P(α) N7A7E6 NP_541657.1 489 LOV+Kinase 194 Brucella abortus 64/81 P(α) N7UVS8 NP_541657.1 489 LOV+Kinase 195 Brucella abortus 65/110 P(α) N7AJ59 NP_541657.1 489 LOV+Kinase 196 Brucella abortus 65/157 P(α) N7U3Y2 NP_541657.1 489 LOV+Kinase 197 Brucella abortus 65/63 P(α) N7VHX7 NP_541657.1 489 LOV+Kinase 198 Brucella abortus 67/781 P(α) N7ASN3 NP_541657.1 489 LOV+Kinase 199 Brucella abortus 67/93 P(α) N7VRX4 NP_541657.1 489 LOV+Kinase 200 Brucella abortus 68-3396P P(α) S3TMU2 NP_541657.1 489 LOV+Kinase 201 Brucella abortus 76-1413 P(α) S3RZI8 NP_541657.1 489 LOV+Kinase 202 Brucella abortus 78/14 P(α) N7US78 NP_541657.1 489 LOV+Kinase 203 Brucella abortus 78/32 P(α) N7WH17 NP_541657.1 489 LOV+Kinase 204 Brucella abortus 78/36 P(α) N7A0T6 NP_541657.1 489 LOV+Kinase 205 Brucella abortus 80/101 P(α) N7VBV9 NP_541657.1 489 LOV+Kinase 206 Brucella abortus 80/102 P(α) N7BFC1 NP_541657.1 489 LOV+Kinase 207 Brucella abortus 80/108 P(α) N7BQ67 NP_541657.1 489 LOV+Kinase 208 Brucella abortus 80/28 P(α) N7WPT0 NP_541657.1 489 LOV+Kinase 209 Brucella abortus 80-1399 P(α) S3RXL3 NP_541657.1 489 LOV+Kinase 210 Brucella abortus 82-2330 P(α) S3SEP8 NP_541657.1 489 LOV+Kinase 211 Brucella abortus 82-3893 P(α) S3RYB1 NP_541657.1 489 LOV+Kinase 212 Brucella abortus 84/26 P(α) N7VRB7 NP_541657.1 489 LOV+Kinase 213 Brucella abortus 84-0928 P(α) S3RC75 NP_541657.1 489 LOV+Kinase 214 Brucella abortus 85/140 P(α) N7BTA4 NP_541657.1 489 LOV+Kinase 215 Brucella abortus 85/69 P(α) N7W4L9 NP_541657.1 489 LOV+Kinase 216 Brucella abortus 85-1058 P(α) S3X8D7 NP_541657.1 489 LOV+Kinase 217 Brucella abortus 863/67 P(α) N7C384 NP_541657.1 489 LOV+Kinase 218 Brucella abortus 87/28 P(α) N7XPS1 NP_541657.1 489 LOV+Kinase 219 Brucella abortus 87-0095 P(α) S3W4M5 NP_541657.1 489 LOV+Kinase 220 Brucella abortus 87-2211 P(α) S3VXQ7 NP_541657.1 489 LOV+Kinase 221 Brucella abortus 877/67 P(α) N7XME5 NP_541657.1 489 LOV+Kinase 222 Brucella abortus 88/19 P(α) N7CBP8 NP_541657.1 489 LOV+Kinase 223 Brucella abortus 88/217 P(α) N7WYJ1 WP_006091747.1 489 LOV+Kinase 224 Brucella abortus 88/226 P(α) N7BPT2 NP_541657.1 489 LOV+Kinase 225 Brucella abortus 89-0363 P(α) S3R3J0 NP_541657.1 489 LOV+Kinase 226 Brucella abortus 90/50 P(α) N7BZI6 NP_541657.1 489 LOV+Kinase 227 Brucella abortus 90-0737 P(α) S3Q4A1 NP_541657.1 489 LOV+Kinase 228 Brucella abortus 90-0742 P(α) S3RJ59 NP_541657.1 489 LOV+Kinase 229 Brucella abortus 90-0775 P(α) S3QCW3 NP_541657.1 489 LOV+Kinase 230 Brucella abortus 90-0962 P(α) S3R6U3 NP_541657.1 489 LOV+Kinase 231 Brucella abortus 90-1280 P(α) S3Q5W1 NP_541657.1 489 LOV+Kinase 232 Brucella abortus 93/1 P(α) N7D2H4 NP_541657.1 489 LOV+Kinase 233 Brucella abortus 93/2 P(α) R8VWD1 NP_541657.1 489 LOV+Kinase 234

A6

Brucella abortus 94-1313 P(α) S3QH15 NP_541657.1 489 LOV+Kinase 235 Brucella abortus A13334 P(α) G8T504 YP_005114240.1/YP_223408.1 458 LOV+PAS+Kinase 236 Brucella abortus B10-0018 P(α) S3NW52 NP_541657.1 489 LOV+Kinase 237 Brucella abortus B10-0091 P(α) S3PQB4 NP_541657.1 489 LOV+Kinase 238 Brucella abortus B10-0973 P(α) S3PCT0 NP_541657.1 489 LOV+Kinase 239 96 Brucella abortus biovar 1 str. 9-941 P(α) Q577Y7 YP_223408.1 458 LOV+PAS+ Kinase 240

Brucella abortus bv. 1 str. NI010 P(α) H3QEE3 EHR17495.1/NP_541657.1 489 LOV+Kinase+PAS 241 Brucella abortus bv. 1 str. NI016 P(α) H3QN03 EHR18337.1/NP_541657.1 489 LOV+Kinase+PAS 242 Brucella abortus bv. 1 str. NI021 P(α) H3QX28 EHR26941.1/NP_541657.1 489 LOV+Kinase+PAS 243 Brucella abortus bv. 1 str. NI259 P(α) H3R3M0 EHR27594.1/NP_541657.1 489 LOV+Kinase+PAS 244 Brucella abortus bv. 1 str. NI435a P(α) H3PCZ9 EHR09267.1/NP_541657.1 489 LOV+Kinase+PAS 245 Brucella abortus bv. 1 str. NI474 P(α) H3PNQ1 EHR07958.1/NP_541657.1 489 LOV+Kinase+PAS 246 Brucella abortus bv. 1 str. NI486 P(α) H3PTS7 EHR11756.1/NP_541657.1 489 LOV+Kinase+PAS 247 Brucella abortus bv. 1 str. NI488 P(α) H3PZJ2 EHR26142.1/NP_541657.1 489 LOV+Kinase+PAS 248 97 Brucella abortus bv. 2 str.86/8/59 P(α) C9V2E2 WP_002966045.1 456 LOV+PAS+Kinase 249 98 Brucella abortus bv. 3 str. Tulya P(α) C9UTV3 WP_002966045.1 456 LOV+PAS+Kinase 250 99 Brucella abortus bv. 4 str.292 P(α) C9UJF2 WP_002967295.1 179 Short‐LOV 251

100 Brucella abortus bv. 5 str. B3196 P(α) D7H767 EFH32827.1/NP_541657.1 489 LOV+PAS+Kinase 252 101 Brucella abortus bv. 6 str.870 P(α) C9U9U0 WP_002966045.1 456 LOV+PAS+Kinase 253 102 Brucella abortus bv. 9 str.C68 P(α) C9VPJ9 WP_002966045.1 456 LOV+PAS+Kinase 254 Brucella abortus CNGB 1011 P(α) N7DAK7 NP_541657.1 489 LOV+Kinase 255 Brucella abortus CNGB 1432 P(α) N7CIS4 NP_541657.1 489 LOV+Kinase 256 Brucella abortus CNGB 308 P(α) N7CYG9 NP_541657.1 489 LOV+Kinase 257 Brucella abortus CNGB 436 P(α) N7D8M7 NP_541657.1 489 LOV+Kinase 258 Brucella abortus CNGB 752 P(α) N7EJN5 NP_541657.1 489 LOV+Kinase 259 Brucella abortus CNGB 759 P(α) N7DJA9 NP_541657.1 489 LOV+Kinase 260 Brucella abortus CNGB 966 P(α) N7F2F4 NP_541657.1 489 LOV+Kinase 261 Brucella abortus F1/06 B1 P(α) N7F3R6 NP_541657.1 489 LOV+Kinase 262 Brucella abortus F1/06-B21 P(α) N7YE57 NP_541657.1 489 LOV+Kinase 263 Brucella abortus F10/05-11 P(α) N7YGE1 NP_541657.1 489 LOV+Kinase 264 Brucella abortus F10/06-3 P(α) N7Z0T9 NP_541657.1 489 LOV+Kinase 265 Brucella abortus F2/06-8 P(α) N7FEA3 WP_006234595.1 375 LOV+Kinase 266 Brucella abortus F3/01-300 P(α) N7FLM3 NP_541657.1 489 LOV+Kinase 267 Brucella abortus F3/07-1 P(α) N7FVJ3 NP_541657.1 489 LOV+Kinase 268 Brucella abortus F5/04-7 P(α) N7Z418 NP_541657.1 489 LOV+Kinase 269 Brucella abortus F6/05-2 P(α) N7FAF8 NP_541657.1 489 LOV+Kinase 270 Brucella abortus F6/05-3 P(α) N7Y6J6 NP_541657.1 489 LOV+Kinase 271 Brucella abortus F6/05-4 P(α) N7ZND9 NP_541657.1 489 LOV+Kinase 272 Brucella abortus F6/05-9 P(α) N8A0V9 NP_541657.1 489 LOV+Kinase 273 Brucella abortus I103_(UK3/01) P(α) R8WBW5 NP_541657.1 489 LOV+Kinase 274 Brucella abortus levi gila P(α) N7GL72 NP_541657.1 489 LOV+Kinase 275 Brucella abortus LEVI237 P(α) N7GMY5 NP_541657.1 489 LOV+Kinase 276 Brucella abortus NCTC 8038 P(α) D0ATW6 EEW81936.1/YP_001932550.1 489 LOV+PAS+Kinase 277 Brucella abortus NI240 P(α) N7GW46 NP_541657.1 489 LOV+Kinase 278 Brucella abortus NI274 P(α) N7H5I5 NP_541657.1 489 LOV+Kinase 279 Brucella abortus NI352 P(α) N8A4N3 NP_541657.1 489 LOV+Kinase 280 Brucella abortus NI380 P(α) N7HEI6 NP_541657.1 489 LOV+Kinase 281 Brucella abortus NI388 P(α) N7HVQ9 NP_541657.1 489 LOV+Kinase 282 Brucella abortus NI422 P(α) N8AH36 NP_541657.1 489 LOV+Kinase 283

A7

Brucella abortus NI492 P(α) N7GUN1 NP_541657.1 489 LOV+Kinase 284 Brucella abortus NI495a P(α) N8AG43 NP_541657.1 489 LOV+Kinase 285 Brucella abortus NI518 P(α) N7I5T2 NP_541657.1 489 LOV+Kinase 286 Brucella abortus NI593 P(α) N7IMP0 NP_541657.1 489 LOV+Kinase 287 Brucella abortus NI613 P(α) N7IQC5 NP_541657.1 489 LOV+Kinase 288 Brucella abortus NI622 P(α) N7HW91 NP_541657.1 489 LOV+Kinase 289 Brucella abortus NI628 P(α) N7I4W1 NP_541657.1 489 LOV+Kinase 290 Brucella abortus NI633 P(α) N7JHA9 NP_541657.1 489 LOV+Kinase 291 Brucella abortus NI639 P(α) N7IUD0 NP_541657.1 489 LOV+Kinase 292 Brucella abortus NI645 P(α) N7K5J7 NP_541657.1 489 LOV+Kinase 293 Brucella abortus NI649 P(α) N7K6Q2 NP_541657.1 489 LOV+Kinase 294 Brucella abortus R42-08 P(α) N7ZQU9 NP_541657.1 489 LOV+Kinase 295 Brucella abortus RB51-AHVLA P(α) N8L9B2 NP_541657.1 489 LOV+Kinase 296 Brucella abortus S19 P(α) B2SB67 YP_001932550.1 489 LOV+PAS+ Kinase 297 103 Brucella canis 79/122 P(α) N8AYL0 NP_541657.1 489 LOV+Kinase 298 Brucella canis ATCC 23365 P(α) A9MBM8 YP_001594536.1/NP_541657.1 463 LOV+PAS+ Kinase 299 Brucella canis CNGB 1172 P(α) N7KG92 NP_541657.1 489 LOV+Kinase 300 Brucella canis CNGB 1324 P(α) N9S6M2 NP_541657.1 489 LOV+Kinase 301 Brucella canis CNGB 513 P(α) N8A4Z2 NP_541657.1 489 LOV+Kinase 302 Brucella canis F7/05A P(α) N9TZC9 NP_541657.1 489 LOV+Kinase 303 Brucella canis HSK A52141 P(α) G8SWF4 YP_005152773.1/YP_223408.1 458 LOV+PAS+Kinase 304 Brucella canis UK10/02 P(α) N7JSW0 NP_541657.1 489 LOV+Kinase 305 104 Brucella ceti B1/94 P(α) C9VFB0 WP_002966045.1 456 LOV+PAS+Kinase 306 Brucella ceti M13/05/1 P(α) C9TAF8 WP_006641754.1 456 LOV+PAS+Kinase 307 Brucella ceti M490/95/1 P(α) D1FCE4 WP_002966045.1 456 LOV+PAS+Kinase 308 Brucella ceti M644/93/1 P(α) C9T165 WP_006641754.1 456 LOV+PAS+Kinase 309 Brucella ceti str. Cudo P(α) C0GBC6 WP_006016110.1/WP_002970660.1 496 LOV+PAS+ Kinase 310 105 Brucella melitensis ( strain M5-90) P(α) F2GXX4 YP_005602181.1/YP_223408.1 458 LOV+PAS+Kinase 311 Brucella melitensis (strain M28) P(α) F2HYM1 YP_005598818.1/YP_223408.1 458 PAS+LOV+Kinase 312 Brucella melitensis 16M P(α) Q8YC53 NP_541657.1 489 LOV+PAS+ Kinase 313 Brucella melitensis 64/150 P(α) N7L6K7 NP_541657.1 489 LOV+Kinase 314 Brucella melitensis 66/59 P(α) N7L954 NP_541657.1 489 LOV+Kinase 315 Brucella melitensis ATCC 23457 P(α) C0RLA9 YP_002734346.1/NP_541657.1 463 LOV+PAS+ Kinase 316 Brucella melitensis B115 P(α) N8KUY5 NP_541657.1 489 LOV+Kinase 317 Brucella melitensis BG2 (S27) P(α) N8BQL3 NP_541657.1 489 LOV+Kinase 318 106 Brucella melitensis biotype 1 NCTC 10094 P(α) D0B724 EEW87416.1/NP_541657.1 489 LOV+PAS+Kinase 319 107 Brucella melitensis bv. 1 str. Rev.1 P(α) D1EUC3 WP_002966045.1 456 LOV+PAS+Kinase 320 108 Brucella melitensis bv. 2 str.63/9 P(α) D0GAY7 EEZ16518.1/NP_541657.1 489 PAS+LOV+Kinase 321 109 Brucella melitensis bv. 3 str. Ether P(α) D1F3T4 WP_004684957.1 456 LOV+PAS+Kinase 322 Brucella melitensis CNGB 1076 P(α) N7KEE3 NP_541657.1 489 LOV+Kinase 323 Brucella melitensis CNGB 1120 P(α) N7LPJ2 NP_541657.1 489 LOV+Kinase 324 Brucella melitensis CNGB 290 P(α) N7L3G2 NP_541657.1 489 LOV+Kinase 325 Brucella melitensis F1/06 B10 P(α) N8BTU0 NP_541657.1 489 LOV+Kinase 326 Brucella melitensis F10/05-2 P(α) N7LAN8 NP_541657.1 489 LOV+Kinase 327 Brucella melitensis F10/06-16 P(α) N8AVE7 NP_541657.1 489 LOV+Kinase 328 Brucella melitensis F15/06-7 P(α) N8L9A1 WP_005975426.1 489 LOV+Kinase 329 Brucella melitensis F2/06-6 P(α) N7MP94 NP_541657.1 489 LOV+Kinase 330 Brucella melitensis F3/02 P(α) N7MZL6 NP_541657.1 489 LOV+Kinase 331 Brucella melitensis F5/07-239A P(α) N7N8P6 WP_005975426.1 489 LOV+Kinase 332

A8

Brucella melitensis F6/05-6 P(α) N7N2Y6 NP_541657.1 489 LOV+Kinase 333 Brucella melitensis F8/01-155 P(α) N8CHP3 NP_541657.1 489 LOV+Kinase 334 Brucella melitensis F9/05 P(α) N8BBC7 NP_541657.1 489 LOV+Kinase 335 Brucella melitensis NI P(α) G4PL89 YP_005660943.1/NP_541657.1 463 LOV+PAS+Kinase 336 Brucella melitensis R3/07-2 P(α) N7NQR7 WP_005975426.1 489 LOV+Kinase 337 Brucella melitensis UK14/06 P(α) N8CYC4 NP_541657.1 489 LOV+Kinase 338 Brucella melitensis UK19/04 P(α) N7NKY4 NP_541657.1 489 LOV+Kinase 339 Brucella melitensis UK22/04 P(α) N8BVK8 NP_541657.1 489 LOV+Kinase 340 Brucella melitensis UK22/06 P(α) N7P9M1 NP_541657.1 489 LOV+Kinase 341 Brucella melitensis UK23/06 P(α) N8DD80 NP_541657.1 489 LOV+Kinase 342 Brucella melitensis Uk24/06 P(α) N8DSU1 NP_541657.1 489 LOV+Kinase 343 Brucella melitensis UK29/05 P(α) N8DYS6 NP_541657.1 489 LOV+Kinase 344 Brucella melitensis UK3/06 P(α) N8D0C9 NP_541657.1 489 LOV+Kinase 345 Brucella melitensis UK31/99 P(α) N8EGG8 WP_005975426.1 489 LOV+Kinase 346 Brucella melitensis UK37/05 P(α) N8DI44 NP_541657.1 489 LOV+Kinase 347 110 Brucella microti CCM 4915 P(α) C7LI74 YP_003105374.1 489 LOV+PAS+ Kinase 348 111 Brucella neotomae 5K33 P(α) C9V5Q3 WP_004687274.1 456 LOV+PAS+Kinase 349 112 Brucella ovis ATCC 25840 P(α) A5VUS1 YP_001257576.1 463 LOV+PAS+ Kinase 350 113 Brucella pinnipedialis B2/94 P(α) C9TZH WP_002966045.1 456 LOV+PAS+Kinase 351 Brucella pinnipedialis B2/94 P(α) F9YN64 YP_004757837.1/NP_541657.1 489 LOV+PAS+Kinase 352 Brucella pinnipedialis M292/94/1 P(α) D1ELF4 WP_002966045.1 456 LOV+PAS+Kinase 353 114 Brucella sp. 56/94 P(α) N8FIV6 NP_541657.1 489 LOV+Kinase 354 115 Brucella sp. 63/311 P(α) N8FUE5 WP_006164629.1 489 LOV+Kinase 355 116 Brucella sp. 83/13 P(α) D1D1A4 WP_008936815.1 456 LOV+PAS+Kinase 356 117 Brucella sp. BO1 P(α) E0DRB7 WP_008510638.1 489 LOV+PAS+Kinase 357 118 Brucella sp. BO2 P(α) E2PN86 WP_009364301.1 434 LOV+Kinase 358 119 Brucella sp. F23/97 P(α) N8G2R7 NP_541657.1 489 LOV+Kinase 359 120 Brucella sp. F5/99 P(α) D0REC6 EEY24775.1/NP_541657.1 489 LOV+PAS+Kinase 360 121 Brucella sp. F8/99 P(α) N8GJ09 NP_541657.1 489 LOV+Kinase 361 122 Brucella sp. F96/2 P(α) N8FEG5 NP_541657.1 489 LOV+Kinase 362 123 Brucella sp. NF 2653 P(α) E0DXH7 WP_009363103.1 489 LOV+PAS+Kinase 363 124 Brucella sp. NVSL 07-0026 P(α) D6LSE WP_002966045.1 456 LOV+PAS+Kinase 364 125 Brucella sp. UK1/97 P(α) N8FUZ7 NP_541657.1 489 LOV+Kinase 365 126 Brucella sp. UK40/99 P(α) N8H492 NP_541657.1 489 LOV+Kinase 366 127 Brucella sp. UK5/01 P(α) N7P2W7 NP_541657.1 489 LOV+Kinase 367 128 Brucella suis 01-5744 P(α) N8HLS9 NP_541657.1 489 LOV+Kinase 368 Brucella suis 1330 P(α) Q8FW73 NP_699772.1 463 LOV+PAS+ Kinase 369 Brucella suis 63/252 P(α) N7QG29 NP_541657.1 489 LOV+Kinase 370 Brucella suis 63/261 P(α) N8I3A5 NP_541657.1 489 LOV+Kinase 371 Brucella suis 92/29 P(α) N7QIN4 NP_541657.1 489 LOV+Kinase 372 Brucella suis 92/63 P(α) N7PMB2 NP_541657.1 489 LOV+Kinase 373 Brucella suis 94/11 P(α) N7Q4V8 NP_541657.1 489 LOV+Kinase 374 Brucella suis ATCC 23445 P(α) A9WYQ7 YP_001622395.1/NP_541657.1 463 LOV+PAS+ Kinase 375 129 Brucella suis bv. 3 str686 P(α) D0PFT WP_002966045.1 456 LOV+PAS+Kinase 376 130 Brucella suis bv. 4 str. 40 P(α) D0BGV2 WP_004692249.1 489 LOV+PAS+Kinase 377 131 Brucella suis bv. 5 str.513 P(α) D0P6S3 WP_002966045.1 456 LOV+PAS+Kinase 378 Brucella suis CNGB 247 P(α) N8GXW2 NP_541657.1 489 LOV+Kinase 379 Brucella suis CNGB 786 P(α) N7Q721 NP_541657.1 489 LOV+Kinase 380 Brucella suis F12/02 P(α) N8IR38 NP_541657.1 489 LOV+Kinase 381

A9

Brucella suis F4/06-146 P(α) N7QNL3 NP_541657.1 489 LOV+Kinase 382 Brucella suis F5/03-2 P(α) N7RVY7 NP_541657.1 489 LOV+Kinase 383 Brucella suis F5/05-10 P(α) N8IZA7 NP_541657.1 489 LOV+Kinase 384 Brucella suis F5/05-4 P(α) N8HS15 NP_541657.1 489 LOV+Kinase 385 Brucella suis F7/06-1 P(α) N8JI74 NP_541657.1 489 LOV+Kinase 386 Brucella suis F7/06-2 P(α) N8JJG0 NP_541657.1 489 LOV+Kinase 387 Brucella suis F7/06-5 P(α) N8ILB3 NP_541657.1 489 LOV+Kinase 388 Brucella suis F8/06-1 P(α) N8K0M4 NP_541657.1 489 LOV+Kinase 389 Brucella suis F8/06-2 P(α) N7R8U4 NP_541657.1 489 LOV+Kinase 390 Brucella suis F8/06-3 P(α) N8KIG9 NP_541657.1 489 LOV+Kinase 391 Brucella suis F9/06-1 P(α) N8KJS5 NP_541657.1 489 LOV+Kinase 392 Brucella suis VBI22 P(α) G8NMK8 YP_005108587.1/NP_541657.1 463 LOV+PAS+Kinase 393 132 Caulobacter crescentus (strain NA1000 / CB15N) P(α) B8GYF7 YP_002515662.1/NP_419104.2 368 LOV+ Kinase 394 Caulobacter crescentus CB15 P(α) Q9ABE3 NP_419104.2 449 LOV+ Kinase 395 Caulobacter crescentus OR37 P(α) R0EN90 WP_004615751.1 368 LOV+Kinase 396 133 Caulobacter segnis DSM 7131 P(α) D5VP68 YP_003594909.1 366 LOV+Kinase 397 134 Caulobacter sp. AP07 P(α) J3A321 WP_007673901.1 369 LOV+Kinase 398 135 Caulobacter sp. JGI 0001013-O16 P(α) WP_018061565.1 373 LOV+Kinase 399 136 Caulobacter sp. K31 P(α) B0T3W0 YP_001684922.1 360 LOV+ Kinase 400 B0T127 YP_001686173.1 369 LOV+ Kinase 401 B0T3W1 YP_001684923.1 922 LOV+3PAS +Kinase+RR 402 137 Citreicella sp. 357 P(α) I1B280 WP_009502647.1 178 Short‐LOV 403 138 Citreicella sp. SE45 P(α) D0CZ83 WP_008883518.1 182 Short‐LOV 404 139 Citromicrobium bathyomarinum P(α) WP_010236370.1 335 LOV+Kinase 405 140 Citromicrobium sp. JLT1363 P(α) WP_010408641.1 358 LOV+Kinase 406 WP_010412930.1 222 LOV+RR 407 141 Dinoroseobacter shibae DFL 12 P(α) A8LHT YP_001532478.1 338 LOV+ Kinase 408 A8LNC2 YP_001533236.1 920 LOV+PAS+PAS+Kinase+RR 409 A8LP63 YP_001533346.1 139 Short‐LOV 410 142 Elioraea tepidiphila P(α) WP_019014442.1 671 LOV+Kinase+RR+HPT 411 143 Erythrobacter litoralis HTCC2594 P(α) Q2NB98 YP_457840.1 225 LOV+HTH 412 Q2NB77 YP_457861.1 346 LOV+ Kinase 413 Q2N9L9 YP_458419.1 362 LOV+ Kinase 414 Q2NCA3 YP_457485.1 360 LOV+ Kinase 415 144 Erythrobacter sp. NAP1 P(α) A3WAQ8 WP_007164748.1 358 LOV+ Kinase 416 145 Erythrobacter sp. SD-21 P(α) A5PBU7 WP_006833624.1 359 LOV+ Kinase 417 146 Fulvimarina pelagi HTCC2506 P(α) Q0G496 WP_007067960.1 420 LOV+ Kinase 418 147 Gluconacetobacter europaeus P(α) WP_019087014.1 213 LOV+RR 419 148 Gluconobacter frateurii NBRC 103465 P(α) GAD09355.1 550 LOV+Kinase+RR 420 149 Gluconobacter thailandicus NBRC 3255 P(α) M9M8A6 WP_007284404.1 578 LOV+Kinase+RR 421 150 Granulibacter bethesdensis CGDNIH1 P(α) Q0BT22 YP_744953.1 185 Short‐LOV 422 151 Hyphomicrobium sp. 99 P(α) WP_020186668.1 383 LOV+Kinase 423 152 Ketogulonicigenium vulgare str. Y25 P(α) E3F4V0 YP_003944033.1 483 LOV+PAS+Kinase 424 Ketogulonicigenium vulgare WSH-001 P(α) F9YAW8 YP_003944033.1 483 LOV+PAS+Kinase 425 153 Labrenzia alexandrii DFL-11 P(α) B9QXI1 WP_008197038.1 124 Short‐LOV 426 B9QXR5 WP_008189163.1 369 LOV+ Kinase 427 154 Loktanella hongkongensis P(α) WP_017927856.1 360 LOV+Kinase 428 WP_017929482.1 330 LOV+Kinase 429 155 Magnetospirillum magnetotacticum P(α) WP_009866659.1 358 LOV+Kinase 430

A10

P(α) WP_009865584.1 425 LOV+Kinase 431 156 Manganese-oxidizing bacterium (strain SI85-9A1) P(α) Q1YFS4 WP_009210920.1 389 LOV+ Kinase 432 Manganese-oxidizing bacterium (strain SI85-9A1) P(α) Q1YEU2 WP_009211252.1 415 LOV+ Kinase 433 157 Mesorhizobium australicum LMG 24608 P(α) L0KJN1 YP_007304602.1 367 LOV+Kinase 434 Mesorhizobium australicum LMG 24609 P(α) L0KP22 YP_007305199.1 382 LOV+Kinase 435 158 Mesorhizobium ciceri bv. biserrulae (strain HAMBI 2942) P(α) E8TG50 YP_004142370.1 382 LOV+Kinase 436 159 Mesorhizobium loti P(α) WP_019859431.1 572 LOV+GGDEF+EAL 437 WP_019859046.1 369 LOV+Kinase 438 160 Methylobacterium chloromethanicum CM4 P(α) B7KUQ2 YP_002422209.1 533 LOV+Kinase+RR 439 B7KW67 YP_002422352.1 354 LOV+Kinase 440 B7KN66 YP_002423111.1 366 LOV+Kinase 441 B7KX89 YP_002424066.1 890 LOV+PAS+GAF+Kinase+RR 442 B7KVX8 YP_002420722.1/YP_001639119.1 541 LOV+Kinase+RR 443 B7L0N0 YP_002419681.1 488 LOV+PAS+ Kinase 444 161 Methylobacterium extorquens AM1 P(α) C5B055 YP_002962682.1/YP_001639119.1 541 LOV+Kinase+RR 445 C5AXM1 YP_002964366.1 533 LOV+Kinase+RR 446 C5B09 YP_002962726.1 492 LOV+PAS+Kinase 447 C5AYD0 YP_002964506.1 354 LOV+Kinase 448 C5AVA5 YP_002961850.1 488 LOV+PAS+Kinase 449 C5B328 YP_002965335.1 351 LOV+Kinase 450 Methylobacterium extorquens DM4 P(α) C7CG25 YP_003067865.1/YP_001639119.1 541 LOV+Kinase+RR 451 C7CC12 YP_003069406.1 533 LOV+Kinase+RR 452 C7CDA8 YP_003066654.1 488 LOV+PAS+Kinase 453 C7CCX6 YP_003069551.1 354 LOV+Kinase 454 C7CJE3 YP_003070459.1 351 LOV+Kinase 455 Methylobacterium extorquens DSM 13060 P(α) H1KGJ9 EHP93379.1/YP_002961850.1 488 LOV+PAS+Kinase 456 H1KRD3 WP_003604879.1 492 LOV+PAS+Kinase 457 H1KD56 YP_001926756.1 888 LOV+PAS+GAF+Kinase+RR 458 H1KIH3 EHP92693.1/YP_001639119.1 541 LOV+Kinase+RR 459 H1KHY7 WP_003599658.1 366 LOV+Kinase 460 H1KNL7 EHP90884.1/YP_002964506.1 354 LOV+Kinase 461 H1KF02 WP_003597944.1 533 LOV+Kinase+RR 462 H1KRD3 WP_003604879.1 492 LOV+PAS+Kinase 463 Methylobacterium extorquens PA1 P(α) A9VYT5 YP_001640598.1 533 LOV+Kinase+RR 464 A9W705 YP_001640738.1 354 LOV+Kinase 465 A9W8Q8 YP_001641478.1 366 LOV+Kinase 466 A9W392 YP_001639119.1 541 LOV+Kinase+RR 467 A9W12 YP_001638351.1 488 LOV+Kinase 468 162 Methylobacterium mesophilicum SR1.6/6 P(α) M7XWQ9 WP_010687353.1 186 Short‐LOV 469 M7XRI0 WP_010686681.1 1194 LOV+5PAS+Kinase+RR 470 M7YQT1 WP_010684528.1 458 LOV+Kinase 471 M7YNE8 WP_010684883.1 164 Short‐LOV 472 M7Y4Z9 WP_010684081.1 334 LOV+Kinase 473 M7Y7G4 WP_010684609.1 538 LOV+Kinase+RR 474 163 Methylobacterium nodulans ORS 2060 P(α) B8IAH5 YP_002501323.1 559 LOV+Kinase+RR 475 B8IF91 YP_002496105.1 814 LOV+2PAS+Kinase+RR 476 B8IJ45 YP_002502143.1 357 LOV+Kinase 477 164 Methylobacterium populi BJ001 P(α) B1ZJK1 YP_001926022.1 531 LOV+Kinase+RR 478 B1Z812 YP_001923514.1 488 LOV+PAS+ Kinase 479 B1ZCH2 YP_001926756.1 888 LOV+PAS+GAF+Kinase+RR 480

A11

B1ZG87 YP_001924280.1 541 LOV+Kinase+RR 481 B1ZKQ8 YP_001926163.1 354 LOV+Kinase 482 B1ZGT9 YP_001927152.1 366 LOV+Kinase 483 B1ZH86 YP_001923025.1 190 Short‐LOV 484 B1ZI10 YP_001923031.1 901 LOV+3PAS+GAF+Kinase 485 165 Methylobacterium radiotolerans ATCC 27329 P(α) B1M4A2 YP_001757080.1 186 Short‐LOV 486 B1LWD2 YP_001753317.1 334 LOV+ Kinase 487 B1LUV7 YP_001756226.1 539 LOV+Kinase+RR 488 B1M51 YP_001757160.1 164 Short‐LOV 489 B1LSK7 YP_001755992.1 503 LOV+PAS+Kinase 490 B1M4V9 YP_001755688.1 812 LOV+2PAS+Kinase+RR 491 166 Methylobacterium sp. 285MFTsu5.1 P(α) WP_020096052.1 186 Short‐LOV 492 WP_020092559.1 539 LOV+Kinase+RR 493 WP_020091307.1 164 Short‐LOV 494 WP_020093089.1 495 LOV+PAS+Kinase 495 WP_020093482.1 358 LOV+Kinase 496 WP_020094544.1 813 LOV+2PAS+Kinase+RR 497 167 Methylobacterium sp. 4-46 P(α) B0UC38 YP_001773223.1 368 LOV+Kinase 498 B0UAI7 YP_001768942.1 812 LOV+2PAS+Kinase+RR 499 B0UDT0 YP_001771637.1 544 LOV+Kinase+RR 500 168 Methylobacterium sp. 77 P(α) WP_019903241.1 540 LOV+Kinase+RR 501 WP_019905522.1 421 LOV+Kinase 502 WP_019902898.1 499 LOV+PAS+Kinase 503 WP_019903195.1 384 LOV+Kinase 504 WP_019903666.1 801 LOV+2PAS+Kinase+RR 505 169 Methylobacterium sp. 88A P(α) WP_018042785.1 525 LOV+Kinase+RR 506 WP_018045200.1 374 LOV+Kinase 507 WP_018044613.1 1061 LOV+4PAS+Kinase+RR 508 WP_018042266.1 506 LOV+PAS+Kinase 509 WP_018042735.1 388 LOV+Kinase 510 WP_018043311.1 801 LOV+2PAS+Kinase+RR 511 170 Methylobacterium sp. GXF4 P(α) I9WQP0 WP_007566581.1 346 LOV+Kinase 512 I9CC12 WP_007569445.1 489 LOV+Kinase 513 I9CG57 WP_007567616.1 164 Short‐LOV 514 I9CKA6 WP_007564509.1 807 LOV+2PAS+Kinase+RR 515 I9WYU0 WP_007560659.1 373 LOV+Kinase 516 I9LEW2 WP_007565725.1 524 LOV+Kinase+RR 517 171 Methylobacterium sp. MB200 P(α) WP_017485058.1 541 LOV+Kinase+RR 518 WP_017486386.1 531 LOV+Kinase+RR 519 WP_017487214.1 488 LOV+PAS+Kinase 520 WP_017484340.1 842 LOV+PAS+GAF+Kinase 521 WP_017484125.1 351 LOV+Kinase 522 172 Methylobacterium sp. WSM2598 P(α) WP_018263266.1 368 LOV+Kinase 523 WP_018259506.1 544 LOV+Kinase+RR 524 WP_018261724.1 802 LOV+2PAS+Kinase+RR 525 173 Methylocystis parvus P(α) WP_016919364.1 487 DJ‐1+HTH+LOV 526 174 Methylocystis rosea P(α) WP_018409659.1 149 Short‐LOV 527 WP_018407875.1 488 DJ‐1+HTH+LOV 528 WP_018406994.1 150 Short‐LOV 529 175 Methylocystis sp. SC2 P(α) J7QP72 YP_006591864.1 150 Short‐LOV 530

A12

176 Methylocystis sp. SC3 P(α) J7QQR2 YP_006590956.1 488 HTH+LOV 531 177 Microvirga sp. WSM3557 P(α) I4YU75 WP_009763567.1 586 LOV+Kinase+RR 532 I4YYC1 WP_009491709.1 896 LOV+3PAS+Kinase+RR 533 178 Nitrosomonas sp. AL212 P(α) F9ZGQ1 YP_004295366.1 150 Short‐LOV 534 179 Novosphingobium aromaticivorans DSM 12444 P(α) Q2G5U0 YP_497617.1 364 LOV+ Kinase 535 Q2G8Z7 YP_496510.1 223 LOV+HTH 536 180 Novosphingobium nitrogenifigens DSM 19370 P(α) F1ZCX7 WP_008071222.1 196 LOV+RR 537 181 Novosphingobium sp. AP12 P(α) J3AQP3 WP_007676988.1 873 LOV+GAF+Kinase+RR 538 P(α) J2P4S6 WP_007687188.1 470 LOV+Kinase 539 182 Novosphingobium sp. PP1Y P(α) F6ID38 YP_004538180.1 193 Short‐LOV 540 183 Oceanibulbus indolifex HEL-45 P(α) A9DXF0 WP_007118258.1 354 LOV+ Kinase 541 184 Oceanicola granulosus P(α) Q2CIF5 WP_007255024.1 341 LOV+ Kinase 542 185 Oceanicola sp. S124 P(α) WP_010139701.1 346 LOV+Kinase 543 186 Ochrobactrum anthropi P(α) WP_010658851.1 480 LOV+Kinase 544 Ochrobactrum anthropi ATCC 49188 P(α) A6X554 YP_001372187.1 491 LOV+PAS+ Kinase 545 187 Ochrobactrum intermedium 229E P(α) ERM00762.1 495 LOV+PAS+Kinase 546 Ochrobactrum intermedium LMG 3301 P(α) C4WLE3 WP_006468921.1 495 LOV+PAS+ Kinase 547 Ochrobactrum intermedium M86 P(α) M5JPW6 WP_006471383.1 491 LOV+Kinase 548 188 Ochrobactrum sp. CDB2 P(α) M3JKE0 WP_007878669.1 496 LOV+PAS+Kinase 549 189 Ochrobactrum sp. EGD-AQ16 P(α) WP_021587245.1 460 LOV+PAS+Kinase 550 190 Parvularcula bermudensis HTCC2503 P(α) E0TE19 YP_003853982.1 367 LOV+Kinase 551 E0THB6 YP_003855348.1 361 LOV+Kinase 552 191 Phyllobacterium sp. YR531 P(α) J3HS51 WP_008123941.1 485 LOV+Kinase 553 192 Rhizobium etli bv. mimosae str. Mim1 P(α) S5S9C3 YP_008369537.1 345 LOV+Kinase 554 193 Rhizobium gallicum P(α) WP_018446992.1 325 LOV+Kinase 555 194 Rhizobium giardinii P(α) WP_018327555.1 336 LOV+Kinase 556 195 Rhizobium grahamii P(α) WP_016556202.1 349 LOV+Kinase 557 196 Rhizobium leguminosarum P(α) WP_017991794.1 375 LOV+Kinase 558 WP_017996607.1 375 LOV+Kinase 559 WP_018068093.1 345 LOV+Kinase 560 WP_017959402.1 345 LOV+Kinase 561 WP_017997493.1 342 LOV+Kinase 562 WP_017992121.1 345 LOV+Kinase 563 WP_018485836.1 345 LOV+Kinase 564 WP_018496455.1 345 LOV+Kinase 565 197 Rhizobium leguminosarum bv viciae 3841 P(α) Q1M667 YP_771353.1 345 LOV+ Kinase 566 198 Rhizobium leguminosarum bv. trifolii WSM1325 P(α) C6B8Y YP_002978926.1 342 LOV+ Kinase 567 C6B7A8 YP_002984928.1 375 LOV+ Kinase 568 199 Rhizobium leguminosarum bv. trifolii WSM2297 P(α) J0WGH8 WP_003575436.1 345 LOV+Kinase 569 200 Rhizobium leguminosarum bv. trifolii WSM2304 P(α) B6A1G8 YP_002279192.1 345 LOV+ Kinase 570 201 Rhizobium leguminosarum bv. trifolii WSM597 P(α) J0H7F5 WP_003591079.1 345 LOV+Kinase 571 202 Rhizobium leguminosarum bv. viciae WSM1455 P(α) J0BMT6 WP_003548985.1 345 LOV+Kinase 572 P(α) J0BMD1 WP_003548626.1 375 LOV+Kinase 573 203 Rhizobium lupini HPC(L) P(α) K5C4K8 WP_006697873.1 369 LOV+Kinase 574 204 Rhizobium sp. 2MFCol3.1 P(α) WP_018901391.1 205 Short‐LOV 575 WP_018901378.1 369 LOV+Kinase 576 WP_018899439.1 476 LOV+PAS+Kinase 577 WP_018901815.1 482 LOV+PAS+Kinase 578 205 Rhizobium sp. CF080 P(α) J3CCW4 WP_007757319.1 349 LOV+Kinase 579

A13

J2IVB7 WP_007767523.1 375 LOV+Kinase 580 206 Rhizobium sp. JGI 0001005-K05 P(α) WP_018116037.1 365 LOV+Kinase 581 WP_018114278.1 387 LOV+Kinase 582 207 Rhizobium tropici CIAT 899 P(α) L0LP99 YP_007335729.1 368 LOV+Kinase 583 208 Rhodobacter sp. AKP1 P(α) L1KCG9 YP_352285.1 176 Short‐LOV 584 L1K6L9 WP_009565994.1 944 PAS+LOV+PAS+Kinase+RR 585 209 Rhodobacter sphaeroides ATCC 17023 P(α) Q3J0K0 YP_353585.1 945 PAS+LOV+PAS+Kinase+RR 586 Q3J4A0 YP_352285.1 176 Short‐LOV 587 210 Rhodobacter sphaeroides ATCC 17029 P(α) A3PLQ1 YP_001044039.1 941 PAS+LOV+2PAS+Kinase+RR 588 A3PI49 YP_001042787.1/YP_352285.1 176 Short‐LOV 589 211 Rhodobacter sphaeroides KD131 P(α) B9KKQ9 YP_002526207.1 941 PAS+LOV+PAS+Kinase+RR 590 B9KPB3 YP_002524907.1/YP_352285.1 176 Short‐LOV 591 212 Rhodobacter sphaeroides WS8N P(α) F5M486 WP_002720676.1 945 PAS+LOV+Kinase+RR 592 213 Rhodospirillum centenum ATCC 51521 / SW P(α) B6IQQ9 YP_002296608.1 368 LOV+ Kinase 593 214 Roseobacter denitrificans OCh 114 P(α) Q167W8 YP_682411.1 350 LOV+ Kinase 594 215 Roseobacter litoralis DSM 6996 P(α) F7ZD60 YP_004690232.1 350 LOV+Kinase 595 216 Roseobacter sp. CCS2 P(α) A4EHF4 WP_008232737.1 175 Short‐LOV 596 A4EIJ8 WP_008233475.1 181 Short‐LOV 597 217 Roseomonas cervicalis ATCC 49957 P(α) D5RKE3 WP_007004777.1 537 LOV+Kinase+RR 598 218 Roseomonas sp. B5 P(α) WP_019461164.1 807 LOV+2PAS+Kinase+RR 599 219 Roseovarius sp. HTCC2601 P(α) Q0FR10 WP_007797918.1 182 Short‐LOV 600 220 Rubellimicrobium thermophilum DSM 16684 P(α) S9SB69 WP_021096554.1 349 LOV+Kinase 601 221 Ruegeria sp. R11 P(α) B7QQ97 WP_008562686.1 194 Short‐LOV 602 222 Sagittula stellata E-37 P(α) A3K7J WP_005861688.1 169 Short‐LOV 603 223 Salipiger mucosus P(α) WP_020039151.1 182 Short‐LOV 604 224 Sphingobium baderi LL03 P(α) T0GNC9 WP_021244768.1 868 LOV+PAS+GAF+Kinase 605 225 Sphingobium indicum B90A P(α) I5BEG6 WP_007685143.1 572 LOV+Kinase+RR 606 226 Sphingobium japonicum P(α) WP_006948855.1 195 LOV+RR 607 227 Sphingobium lactosutens DS20 P(α) T0IZE5 WP_021224791.1 201 LOV+RR 608 T0HKJ8 WP_021227208.1 592 LOV+Kinase+RR 609 EQB17255.1 201 LOV+RR 610 228 Sphingobium ummariense RL-3 P(α) T0KBW2 WP_021316219.1 572 LOV+Kinase+RR 611 229 Sphingobium xenophagum P(α) WP_017181268.1 582 LOV+Kinase+RR 612 WP_019051957.1 190 LOV+RR 613 WP_017181670.1 190 LOV+RR 614 230 Sphingobium yanoikuyae P(α) WP_010336618.1 185 Short‐LOV 615 Sphingobium yanoikuyae ATCC 51230 P(α) K9DDM0 WP_004210595.1 460 LOV+Kinase 616 K9DBT8 WP_004209647.1 196 LOV+RR 617 K9CRY6 WP_004209577.1 185 Short‐LOV 618 K9CZR2 WP_004208793.1 866 LOV+PAS+GAF+Kinase+RR 619 231 Sphingomonas echinoides P(α) WP_010406583.1 870 LOV+PAS+GAF+Kinase+RR 620 232 Sphingomonas elodea P(α) WP_010544137.1 568 LOV+Kinase+RR 621 WP_010545569.1 193 LOV+RR 622 233 Sphingomonas melonis P(α) WP_020486392.1 488 LOV+PAS+Kinase 623 WP_018250488.1 496 LOV+PAS+Kinase 624 WP_020493474.1 586 LOV+Kinase+RR 625 WP_018250616.1 569 LOV+Kinase+RR 626 234 Sphingomonas sp. ATCC 31555 P(α) WP_019369245.1 569 LOV+PAS+Kinase 627 WP_019369958.1 195 LOV+RR 628

A14

235 Sphingomonas sp. KC8 P(α) WP_010126430.1 191 LOV+RR 629 236 Sphingomonas sp. LH128 P(α) J8VLA8 WP_008831260.1 184 Short‐LOV 630 J8VSB8 WP_008829154.1 186 Short‐LOV 631 237 Sphingomonas sp. Mn802worker P(α) WP_019517892.1 547 LOV+Kinase+RR 632 WP_019515952.1 374 LOV+Kinase 633 238 Sphingomonas sp. PAMC 26605 P(α) WP_010185187.1 368 LOV+Kinase 634 WP_010183492.1 207 LOV+RR 635 239 Sphingomonas sp. PAMC 26617 P(α) WP_010164100.1 536 LOV+Kinase+RR 636 WP_010165385.1 207 LOV+RR 637 WP_010162859.1 849 PAS+LOV+GAF+Kinase+RR 638 WP_010162636.1 207 LOV+RR 639 WP_010161173.1 557 LOV+Kinase+RR 640 240 Sphingomonas sp. PAMC 26621 P(α) WP_010215598.1 207 LOV+RR 641 WP_010217310.1 536 LOV+Kinase+RR 642 241 Sphingomonas sp. S17 P(α) F3WVL3 WP_007404345.1 155 Short‐LOV 643 P(α) F3WVM0 WP_007404471.1 524 LOV+Kinase+RR 644 242 Sphingomonas sp. SKA58 P(α) Q1N7J1 WP_009822011.1 238 LOV+HTH 645 Q1NI33 WP_009823476.1 570 LOV+Kinase+RR 646 243 Sphingopyxis alaskensis RB2256 P(α) Q1GUF5 YP_616050.1 195 LOV+HTH 647 244 Sphingopyxis sp. MC1 P(α) N9WD00 WP_003043817.1 566 LOV+GGDEF+EAL 648 N9UPB3 WP_003050900.1 195 LOV+RR 649 245 Wenxinia marina P(α) WP_018301439.1 178 Short‐LOV 650 246 Accumulibacter phosphatis (strain UW-1) P(β) C7RJT7 YP_003168707.1 143 Short‐LOV 651 247 Acidovorax avenae P(β) WP_019702225.1 544 LOV+Kinase+RR 652 Acidovorax avenae DSM 7227 P(β) F0QBL7 YP_004235943.1 544 LOV+Kinase+RR 653 248 Acidovorax avenae sub. citrulli AAC00-1 P(β) A1TT27 YP_971889.1 544 LOV+Kinase+RR 654 249 Aromatoleum aromaticum EbN1 P(β) Q5P4K8 YP_158656.1 698 Globin+LOV+GGDEF+EAL 655 250 Blood disease bacterium R229 P(β) G2ZKN6 CCA79599.1 1178 3PAS+LOV+GGDEF 656 251 Burkholderia bryophila P(β) WP_020069641.1 1058 2PAS+LOV+GGDEF+EAL 657 252 Burkholderia graminis C4D1M P(β) B1FWL0 WP_006047954.1 1036 PAS+PAS+LOV+ GGDEF+EAL 658 253 Burkholderia kururiensis P(β) WP_017772705.1 1038 2PAS+LOV+GGDEF+EAL 659 254 Burkholderia phenoliruptrix BR3459a P(β) K0DLX0 YP_006832691.1 1036 2PAS+LOV+GGDEF+EAL 660 255 Burkholderia phymatum STM815 P(β) B2JFQ7 YP_001858578.1 533 LOV+Kinase+RR 661 B2JCW5 YP_001856630.1 1040 2PAS+LOV+GGDEF+EAL 662 256 Burkholderia phytofirmans PsJN P(β) B2SX52 YP_001894315.1 1036 PAS+PAS+LOV+ GGDEF+EAL 663 257 Burkholderia sp. BT03 P(β) J3AY22 WP_007745224.1 1040 2PAS+LOV+GGDEF+EAL 664 J2IBD0 WP_007737745.1 533 LOV+Kinase+RR 665 258 Burkholderia sp. CCGE 1002 P(β) D5WBG3 YP_003604003.1 1055 2PAS+LOV+GGDEF+EAL 666 259 Burkholderia sp. CCGE 1003 P(β) E1T757 YP_003905686.1 1036 2PAS+LOV+GGDEF+EAL 667 260 Burkholderia sp. CCGE1001 P(β) E8YMJ9 YP_004226904.1 1036 2PAS+LOV+GGDEF+EAL 668 261 Burkholderia sp. Ch1-1 P(β) I2ICW6 WP_007179328.1 1036 2PAS+LOV+GGDEF+EAL 669 262 Burkholderia sp. H160 P(β) B5WM15 WP_008921106.1 1028 PAS+PAS+LOV+ GGDEF+EAL 670 263 Burkholderia sp. JPY251 P(β) WP_018431938.1 1055 2PAS+LOV+GGDEF+EAL 671 264 Burkholderia sp. RPE64 P(β) YP_008036462.1 1058 PAS+LOV+PAS+GGDEF+EAL 672 265 Burkholderia sp. SJ98 P(β) K8R5H1 WP_008351594.1 1032 2PAS+LOV+GGDEF+EAL 673 K8RBL1 WP_008348805.1 950 PAS+LOV+GGDEF+EAL 674 K8RFA8 WP_008344710.1 403 LOV+Kinase 675 266 Burkholderia sp. WSM4176 P(β) WP_018419411.1 1062 2PAS+LOV+GGDEF+EAL 676 267 Burkholderia sp.YI23 P(β) G8M3Y7 YP_004976128.1 1040 2PAS+LOV+GGDEF+EAL 677

A15

268 Burkholderia terrae BS001 P(β) I5D017 WP_007579791.1 1040 2PAS+LOV+GGDEF+EAL 678 I5CKV7 WP_007589128.1 192 Short‐LOV 679 269 Burkholderia xenovorans LB400 P(β) Q145M2 YP_557019.1 1036 PAS+PAS+LOV+ GGDEF+EAL 680 270 Burkholderiales bacterium JOSHI_001 P(β) H5WRX6 WP_009553309.1 875 LOV+Kinase+GGDEF+HAMP 681 271 Caldimonas manganoxidans P(β) WP_019559344.1 1200 GAF+2PAS+LOV+2PAS+Kinase+RR 682 272 Comamonas testosteroni P(β) WP_019042804.1 443 LOV+GGDEF 683 Comamonas testosteroni CNB-2 P(β) D0J0D1 YP_003278898.1 458 LOV+PAS+GGDEF 684 Comamonas testosteroni S44 P(β) D8D2C5 WP_003062841.1 435 PAS+LOV+GGDEF 685 273 Duganella zoogloeoides P(β) WP_019924259.1 560 LOV+Kinase+RR 686 274 Herbaspirillum frisingense GSF30 P(β) R0FWK0 WP_006462257.1 546 LOV+Kinase+RR 687 275 Herbaspirillum seropedicae P(β) WP_017453457.1 546 LOV+Kinase+RR 688 Herbaspirillum seropedical (strain SmR1) P(β) D8IWD2 YP_003775860.1 552 LOV+Kinase+RR 689 276 Herbaspirillum sp. GW103 P(β) I3CVK0 WP_008329090.1 546 LOV+Kinase+RR 690 277 Herbaspirillum sp. JC206 P(β) WP_019142500.1 585 LOV+Kinase+RR 691 278 Herbaspirillum sp. YR522 P(β) J2UWT8 WP_008118789.1 549 LOV+Kinase+RR 692 279 Herminiimonas arsenicoxydans P(β) A4G2U1 YP_001098955.1 944 CHASE+LOV+GGDEF+EAL 693 A4G7R2 YP_001100670.1 313 LOV+GGDEF 694 A4G3M6 YP_001099240.1 818 RR+PAS+LOV+GGDEF+EAL 695 280 Janthinobacterium sp. CG3 P(β) WP_017876122.1 1107 CHASE+LOV+GGDEF+EAL+RR 696 WP_017876665.1 986 PAS+LOV+GGDEF+EAL+RR 697 281 Lutiella nitroferrum 2002 P(β) B9Z647 WP_008955033.1 1072 RR+GAF+PAS+LOV+GGDEF+EAL 698 282 Massilia niastensis P(β) WP_020651816.1 562 LOV+Kinase+RR 699 283 Massilia timonae CCUG 45783 P(β) K9DG25 WP_005665462.1 569 LOV+Kinase+RR 700 284 Methylibium petroleiphilum PM1 P(β) A2SIR0 YP_001021684.1 1317 GAF+3PAS+LOV+2PAS+Kinase+ RR 701 285 Methylovorus sp. SIP3-4 P(β) C6X7I8 YP_003051980.1 821 RR+PAS+LOV+GGDEF+EAL 702 286 Methylovorus sp.str. MP688 P(β) E4QL91 YP_004040548.1 821 RR+PAS+LOV+GGDEF+EAL 703 287 Nitrosomonas sp. (strain Is79A3) P(β) F8GDY9 YP_004695500.1 150 Short‐LOV 704 288 Nitrosomonas sp. AL212 P(β) F9ZGQ1 YP_004295366.1 150 Short‐LOV 705 289 Nitrosospira multiformis ATCC 25196 P(β) Q2Y837 YP_412476.1 152 Short‐LOV 706 290 Nitrosospira sp. APG3 P(β) M5DIF4 WP_004176761.1 157 Short‐LOV 707 291 Oxalobacteraceae bacterium IMCC 9480 P(β) F1VZT5 WP_009666397.1 526 LOV+PAS+Kinase 708 292 Polaromonas naphthalenivorans CJ2 P(β) A1VS30 YP_983379.1 389 LOV+ Kinase 709 293 Pseudogulbenkiania sp. (strain NH8B) P(β) G2IXN9 YP_004848386.1 1072 RR+GAF+PAS+LOV+GGDEF+EAL 710 294 Ralstonia solanacearum P(β) B5RXV5 WP_003274043.1 1178 Hamp+2PAS+LOV+GGDEF+EAL 711 WP_019719220.1 1178 Hamp+2PAS+LOV+GGDEF+EAL 712 D8P2A9 YP_003747462.1 1178 Hamp+2PAS+LOV+GGDEF+EAL 713 B5SBH9 YP_002257212.1 1178 Hamp+2PAS+LOV+GGDEF+EAL 714 Ralstonia solanacearum CMR15 P(β) D8NG57 YP_006060163.1 1178 Hamp+2PAS+LOV+GGDEF+EAL 715 Ralstonia solanacearum FQY_4 P(β) M4UIH4 YP_008237427.1 1178 Hamp+2PAS+LOV+GGDEF+EAL 716 Ralstonia solanacearum GMI1000 P(β) Q8XT61 NP_521815.1 1178 HAMP+2PAS+LOV+GGDEF+EAL 717 Ralstonia solanacearum PSI07 P(β) D8MYZ9 YP_003749222.1 1178 3PAS+LOV+GGDEF+EAL 718 Ralstonia solanacearum SD54 P(β) S7XX18 WP_021155319.1 1178 Hamp+2PAS+LOV+GGDEF+EAL 719 Ralstonia solanacearum str. Po82 P(β) F6G7G0 YP_006031432.1 1234 HAMP+PAS+LOV+GGDEF+EAL 720 Ralstonia solanacearum UW551 P(β) A3RWI2 WP_003264369.1 1234 HAMP+2PAS+LOV+GGDEF+EAL 721 295 Ralstonia sp. AU12-08 P(β) S9S0D4 WP_021192980.1 1201 Hamp+PAS+LOV+GGDEF+EAL 722 296 Ralstonia sp. PBA P(β) I9W2M2 WP_009523483.1 688 PAS+LOV+GGDEF+EAL 723 297 Ralstonia syzygii R24 P(β) G3A8G2 CCA87536.1 1178 3PAS+LOV+GGDEF 724 298 Ramilbacter tataouinensis DSM14655 P(β) F5Y2K4 YP_004618386.1 537 LOV+Kinase+RR 725 299 Rubrivivax benzoatilyticus JA2 P(β) F3LSW2 WP_009857995.1 687 LOV+PAS+GGDEF+EAL 726

A16

P(β) F3LLJ8 WP_009855783.1 856 2PAS+LOV+PAS+Kinase 727 300 Rubrivivax gelatinosus NBRC 100245 P(β) I0HXU9 YP_005439335.1 877 Hamp+PAS+LOV+Kinase 728 Rubrivivax gelatinosus NBRC 100246 P(β) I0HQ12 YP_005436598.1 737 LOV+PAS+GGDEF+EAL 729 301 Sulfuricella denitrificans skB26 P(β) S6AL83 YP_008546461.1 698 LOV+PAS+GGDEF+EAL 730 S6AFR8 YP_008545773.1 677 LOV+PAS+GGDEF+EAL 731 302 Thauera phenylacetica B4P P(β) N6ZRB5 WP_004362938.1 864 HAMP+PAS+LOV+PAS+Kinase 732 N6ZXB3 WP_004364285.1 954 HAMP+2PAS+LOV+PAS+Kinase 733 N6YKT8 WP_004382816.1 738 Globin+LOV+GGDEF+EAL 734 303 Thauera sp. 27 P(β) N6XKW8 WP_002937138.1 1133 Hamp+2PAS+LOV+PAS+Kinase 735 304 Acidithiobacillus caldus ATCC 51756 P(γ) C6NR21 WP_004867363.1 913 GAF+LOV+PAS+GGDEF+EAL 736 Acidithiobacillus caldus str. SM-1 P(γ) F9ZQB1 YP_004747583.1 913 GAF+LOV+PAS+GGDEF+EAL 737 305 Acidithiobacillus ferrooxidans ATCC 23270 P(γ) B7JB43 YP_002426126.1 1057 GAF+LOV+PAS+GAF+GGDEF+EAL 738 306 Acidithiobacillus sp.GGI-221 P(γ) F8XM97 WP_009561169.1 677 LOV+PAS+GAF+GGDEF 739 307 Acinetobacter brisouii ANC 4119 P(γ) N9AXM2 WP_004898317.1 859 GAF+PAS+LOV+GGDEF+EAL 740 308 Acinetobacter Iwoffii SH145 P(γ) D0SWD2 WP_004280312.1 859 GAF+LOV+PAS+GGDEF+EAL 741 Acinetobacter lwoffii P(γ) WP_016806740.1 859 GAF+LOV+PAS+GGDEF+EAL 742 WP_016806740.1 859 GAF+PAS+LOV+GGFEF+EAL 743 Acinetobacter lwoffii CIP 70.31 P(γ) N9H487 WP_005100328.1 537 LOV+GGDEF+EAL 744 Acinetobacter lwoffii NCTC 5866 = CIP 64.10 P(γ) N9H4F1 WP_005096907.1 859 GAF+PAS+LOV+GGDEF+EAL 745 Acinetobacter lwoffii NIPH 478 P(γ) N9HNY3 WP_005106935.1 859 GAF+PAS+LOV+GGDEF+EAL 746 N9HEH7 WP_005107680.1 864 PAS+LOV+GGDEF+EAL 747 Acinetobacter lwoffii NIPH 715 P(γ) N8TVY4 WP_004730980.1 859 GAF+PAS+LOV+GGDEF+EAL 748 309 Acinetobacter radioresistens DSM 6976 P(γ) K6W2B6 WP_005026623.1 855 GAF+PAS+LOV+GGDEF+EAL 749 Acinetobacter radioresistens NIPH 2130 P(γ) N9CGQ6 WP_005019674.1 855 GAF+PAS+LOV+GGDEF+EAL 750 Acinetobacter radioresistens SH164 P(γ) D0T5K2 WP_005019674.1 855 GAF+PAS+LOV+GGDEF 751 Acinetobacter radioresistens SK82 P(γ) C6RJR5 EET83911.1/WP_005019674.1 855 GAF+PAS+LOV+GGDEF+EAL 752 Acinetobacter radioresistens WC-A-157 P(γ) J4R2N6 WP_005406298.1 855 GAF+PAS+LOV+GGDEF+EAL 753 310 Acinetobacter sp. ANC 3789 P(γ) N8VFZ2 WP_004749596.1 854 GAF+PAS+LOV+GGDEF+EAL 754 N8VCG8 WP_004751822.1 846 GAF+PAS+LOV+GGDEF+EAL 755 311 Acinetobacter sp. ANC 3994 P(γ) N8NWV8 WP_004649263.1 861 GAF+PAS+LOV+GGDEF+EAL 756 312 Acinetobacter sp. CIP 101966 P(γ) N9QD69 WP_005262929.1 859 GAF+PAS+LOV+GGDEF+EAL 757 313 Acinetobacter sp. CIP 102136 P(γ) N9PS41 WP_005251802.1 859 GAF+PAS+LOV+GGDEF+EAL 758 314 Acinetobacter sp. CIP 51.11 P(γ) N9PKC5 WP_005246324.1 859 GAF+PAS+LOV+GGDEF+EAL 759 315 Acinetobacter sp. CIP 53.82 P(γ) N9ML36 WP_005177235.1 857 GAF+PAS+LOV+GGDEF+EAL 760 316 Acinetobacter sp. CIP 64.7 P(γ) N9QK63 WP_005266388.1 859 GAF+PAS+LOV+GGDEF+EAL 761 317 Acinetobacter sp. CIP A162 P(γ) N8Q6A8 WP_004646969.1 859 GAF+PAS+LOV+GGDEF+EAL 762 318 Acinetobacter sp. MDS7A P(γ) WP_019837897.1 857 GAF+LOV+PAS+GGDEF+EAL 763 319 Acinetobacter sp. NIPH 2171 P(γ) N9MLY1 WP_005234449.1 850 GAF+PAS+LOV+GGDEF+EAL 764 320 Acinetobacter sp. NIPH 713 P(γ) N9KQ40 WP_005170912.1 861 GAF+PAS+LOV+GGDEF+EAL 765 321 Acinetobacter sp. NIPH 899 P(γ) N8VGG5 WP_004783140.1 821 GAF+PAS+LOV+GGDEF+EAL 766 322 Algicola sagamiensis P(γ) WP_018692423.1 320 LOV+GGDEF 767 323 Aliivibrio fischeri (Vibrio fischeri) P(γ) WP_017019105.1 631 LOV+GGDEF 768 324 Alishewanella agri BL06 P(γ) I9DPX4 WP_008985345.1 1590 PAS+GAF+PAS+LOV+GGDEF+EAL+RR 769 325 Alishewanella jeotgali KCTC 22429 P(γ) H3ZFV5 WP_008950907.1 1590 PAS+GAF+PAS+LOV+GGDEF+EAL+RR 770 326 Alteromonas macleodii AltDE1 P(γ) K7RA87 YP_006975689.1 959 PAS+LOV+Kinase+RR 771 Alteromonas macleodii ATCC 27126 P(γ) J9Y2J7 YP_006746817.1 958 PAS+LOV+Kinase+RR 772 Alteromonas macleodii Black Sea 11 P(γ) K0CV21 YP_006823794.1 959 PAS+LOV+Kinase+RR 773 Alteromonas macleodii DSM 17117 DeePecotype P(γ) F2GAX1 YP_004426010.1 959 PAS+LOV+Kinase+RR 774 Alteromonas macleodii English Channel 673 P(γ) K0CM81 YP_006797832.1 958 LOV+PAS+Kinase+RR 775

A17

Alteromonas macleodii str. 'Aegean Sea MED64' P(γ) S5AQD7 AGP80766.1 959 PAS+LOV+Kinase+RR 776 Alteromonas macleodii str. 'English Channel 615' P(γ) S5ABK9 YP_008191735.1 959 PAS+LOV+Kinase+RR 777 Alteromonas macleodii str. 'Ionian Sea U4' P(γ) S5BBY3 YP_008170856.1 959 PAS+LOV+Kinase+RR 778 S5B6H2 YP_008170856.1 959 PAS+LOV+Kinase+RR 779 Alteromonas macleodii str. 'Ionian Sea U8' P(γ) S5BMV0 YP_008174998.1 959 PAS+LOV+Kinase+RR 780 327 Alteromonas sp. SN2 P(γ) F5Z4R5 YP_004468204.1 956 PAS+LOV+Kinase+RR 781 328 Arhodomonas aquaeolei P(γ) WP_018716398.1 146 Short‐LOV 782 WP_018717064.1 848 GAF+LOV+PAS+GGDEF+EAL 783 329 Bermanella marisrubri P(γ) Q1N482 WP_007018054.1 938 LOV+ Kinase+ RR+RR 784 330 Catenovulum agarivorans P(γ) WP_016956198.1 1106 PAS+LOV+Kinase+RR 785 WP_016956198.1 1106 2PAS+LOV+Kinase+RR 786 331 Chromohalobacter salexigens DSM 3043 P(γ) Q1QUF0 YP_574607.1 836 PAS+LOV+PAS+GGDEF+EAL 787 Q1QUF0 ABE59908.1/YP_574607.1 836 LOV+2PAS+ GGDEF+EAL 788 Q1QU87 YP_574670.1 144 Short‐LOV 789 332 Dyella ginsengisoli P(γ) WP_017460863.1 820 RR+PAS+LOV+GGDEF+EAL 790 WP_017462527.1 823 LOV+PAS+GGDEF+EAL 791 WP_017463133.1 1578 PAS+GAF+PAS+LOV+GGDEF+Globin+EAL 792 333 Ectothiorhodospira sp.PHS-1 P(γ) H1G1Q6 WP_008931310.1 159 Short‐LOV 793 H1G08 WP_008930788.1 150 Short‐LOV 794 334 Fluoribacter dumoffii P(γ) WP_010655036.1 357 LOV+Kinase 795 335 Glaciecola nitratireducens JCM 12485 P(γ) G4QHD6 YP_004871760.1 408 LOV+SPOIIE 796 336 Glaciecola pallidula DSM 14239 = ACAM 615 P(γ) K6ZHY4 WP_006010726.1 408 LOV+SPOIIE 797 337 Hahella ganghwensis P(γ) WP_020410026.1 1211 RR+PAS+LOV+GGDEF+EAL+RR 798 WP_020406443.1 1654 HAMP+PAS+LOV+2PAS+Kinase+RR+Hpt 799 338 Halomonas anticariensis FP35 = DSM 16096 P(γ) S2KPA1 WP_016414477.1 1070 RR+2PAS+LOV+GGDEF+EAL 800 S2KJN8 WP_016418607.1 1329 GAF+PAS+LOV+GGDEF+EAL 801 S2KLF6 WP_016417969.1 694 PAS+LOV+GGDEF+EAL 802 339 Halomonas boliviensis LC1 P(γ) G9EBS6 WP_007112306.1 931 3PAS+LOV+GGDEF+EAL 803 G9EDB9 WP_007113307.1 139 Short‐LOV 804 340 Halomonas jeotgali P(γ) WP_017430872.1 139 Short‐LOV 805 341 Halomonas lutea P(γ) WP_019020310.1 141 Short‐LOV 806 WP_019016980.1 856 GAF+LOV+PAS+GGDEF+EAL 807 WP_019018880.1 857 GAF+LOV+PAS+GGDEF+EAL 808 342 Halomonas smyrnensis P(γ) WP_016856487.1 144 Short‐LOV 809 WP_016853871.1 1335 GAF+LOV+2PAS+GGDEF+EAL 810 WP_016855043.1 851 GAF+LOV+PAS+GGDEF+EAL 811 343 Halomonas sp. A3H3 P(γ) WP_022522746.1 144 Short‐LOV 812 WP_022521218.1 684 PAS+LOV+GGDEF+EAL 813 344 Halomonas sp. GFAJ-1 P(γ) H0J093 WP_009097290.1 874 LOV+PAS+GGDEF+EAL 814 H0J025 WP_009097057.1 145 Short‐LOV 815 H0J1I9 WP_009098247.1 815 2PAS+LOV+GGDEF+EAL 816 345 Halomonas sp. KM-1 P(γ) WP_010628907.1 743 PAS+LOV+GGDEF+EAL 817 WP_010627148.1 144 Short‐LOV 818 WP_010628900.1 1328 GAF+PAS+LOV+GGDEF+EAL 819 WP_010627231.1 1157 PAS+LOV+GGDEF+EAL 820 WP_010629458.1 830 PAS+LOV+GGDEF+EAL+RR 821 346 Halomonas sp.HAL1 P(γ) G4FAF4 WP_008959245.1 709 PAS+LOV+2GGDEF 822 G4F2H5 WP_008956503.1 927 3PAS+LOV+ GGDEF+EAL 823 G4FBI0 WP_008959621.1 144 Short‐LOV 824

A18

347 Halomonas sp.TD01 P(γ) F7SNC3 WP_009723241.1 816 2PAS+LOV+GGDEF+EAL 825 F7SIY3 WP_009721710.1 145 Short‐LOV 826 348 Halomonas stevensii P(γ) WP_016916582.1 145 Short‐LOV 827 WP_016915464.1 814 2PAS+LOV+GGDEF+EAL 828 WP_016915854.1 1161 PAS+LOV+GGDEF+EAL 829 349 Halomonas titanicae BH1 P(γ) L9UD19 WP_009286231.1 685 PAS+LOV+GGDEF+EAL 830 L9U8I4 WP_009287681.1 171 Short‐LOV 831 350 Halomonas zhanjiangensis P(γ) WP_018918585.1 149 Short‐LOV 832 WP_018917662.1 1323 GAF+PAS+LOV+GGDEF+EAL 833 351 Halothiobacillus neapolitanus ATCC23641 P(γ) D0L135 YP_003263455.1 151 Short‐LOV 834 352 Idiomarinasp.A28L P(γ) F7RZ10 WP_007420466.1 880 GAF+PAS+LOV+GGDEF+EAL 835 353 Kangiella aquimarina P(γ) WP_018623315.1 870 GAF+PAS+LOV+GGDEF+EAL 836 354 Kangiella koreensis DSM 16069 P(γ) C7R7Z7 YP_003145547.1 887 GAF+PAS+LOV+GGDEF+EAL 837 355 Kushneria aurantia P(γ) WP_019951323.1 140 Short‐LOV 838 356 Lamprocystis purpurea P(γ) WP_020503819.1 153 Short‐LOV 839 WP_020504715.1 152 Short‐LOV 840 357 Marichromatium purpuratum 984 P(γ) F9TYW6 WP_005222470.1 152 Short‐LOV 841 F9TWG1 WP_005220887.1 1118 3PAS+LOV+Kinase+RR 842 358 Marinobacter adhaerens HP15 P(γ) E4PMK6 YP_005887842.1 552 LOV+GGDEF+EAL 843 359 Marinobacter algicola DG893 P(γ) A6EZP7 CCA87536.1 858 GAF+PAS+LOV+GGDEF+EAL 844 360 Marinobacter lipolyticus SM19 P(γ) R8B0L0 WP_012138208.1 887 GAF+PAS+LOV+GGDEF+EAL 845 361 Marinobacter nanhaiticus D15-8W P(γ) N6WWB0 WP_004580166.1 1520 CHER+PAS+LOV+PAS+GGDEF+EAL 846 N6WWN8 WP_004580316.1 630 MASE1+LOV+GGDEF 847 362 Methylobacter marinus P(γ) WP_020158844.1 846 CONTROLLO 848 WP_020157396.1 152 Short‐LOV 849 363 Methylobacter tundripaludum SV96 P(γ) G3J1D6 WP_006893485.1 738 RR+LOV+LOV+PAS+Kinase 850 364 Methylococcus capsulatus P(γ) WP_017365821.1 640 LOV+GGDEF+EAL 851 Methylococcus capsulatus str. Bath P(γ) Q609J7 YP_113700.1 712 LOV+GGDEF+EAL 852 Q607S2 YP_114126.1 853 PAS+LOV+3PAS+SPOIIE 853 365 Methylomicrobium alcaliphilum DSM 19304 P(γ) G4T2M2 YP_004918336.1 164 Short‐Lov 854 G4T2L9 YP_004918333.1 148 Short‐Lov 855 G4T0F8 YP_004918135.1 1418 Kinase+2RR+LOV+4PAS+Kinase+RR 856 366 Methylomicrobium buryatense P(γ) WP_017840040.1 1418 Hpt+2RR+LOV+4PAS+Kinase 857 WP_017842760.1 164 Short‐LOV 858 WP_017842762.1 148 Short‐LOV 859 367 Methylomonas methanica MC09 P(γ) G0A1Q1 YP_004512611.1 150 Short‐LOV 860 368 Methylomonas sp. MK1 P(γ) WP_020482233.1 151 Short‐LOV 861 369 Methylosarcina fibrata P(γ) WP_020564946.1 840 CONTROLLO 862 370 Methylovulum miyakonense P(γ) WP_019864760.1 153 Short‐LOV 863 371 Nitrosococcus halophilus Nc4 P(γ) D5BVD1 YP_003525946.1| 149 Short‐LOV 864 372 Nitrosococcus oceani AFC27 P(γ) B6C5R4 WP_002813571.1 150 Short‐LOV 865 Nitrosococcus oceani ATCC 19707 P(γ) Q3J6W8 YP_344958.1 150 Short‐LOV 866 373 Nitrosococcus watsoni C-113 P(γ) D8KC92 YP_003762084.1 150 Short‐LOV 867 374 Oceanimonas smirnovii P(γ) WP_019936022.1 854 GAF+LOV+PAS+GGDEF+EAL 868 375 Pseudoalteromonas citrea P(γ) WP_010362109.1 1105 PAS+LOV+Kinase+RR 869 376 Pseudoalteromonas flavipulchra P(γ) WP_010607534.1 1103 PAS+LOV+PAS+Kinase+RR 870 377 Pseudoalteromonas piscicida P(γ) WP_010374796.1 1103 PAS+LOV+PAS+Kinase+RR 871 378 Pseudoalteromonas rubra P(γ) WP_010380647.1 1107 2PAS+LOV+Kinase+RR 872 379 Pseudoalteromonas sp. BSi20495 P(γ) G7G480 WP_008137009.1 1098 PAS+LOV+Kinase+2RR 873

A19

380 Pseudoalteromonas sp. Bsw20308 P(γ) M5H4P7 WP_007376873.1 1098 PAS+LOV+Kinase+RR 874 381 Pseudoalteromonas sp. NJ631 P(γ) WP_017218143.1 1103 PAS+LOV+PAS+Kinase+RR 875 382 Pseudoalteromonas sp. SM9913 P(γ) E6RNZ1 YP_004068043.1 1101 PAS+LOV+Kinase+2EAL 876 383 Pseudoalteromonas undina P(γ) WP_010391230.1 1101 PAS+LOV+Kinase+RR 877 384 Pseudomonas P(γ) WP_010206458.1 155 Short‐LOV 878 WP_018927172.1 158 Short‐LOV 879 385 Pseudomonas aeruginosa B136-33 P(γ) M9S7A7 YP_007711618.1 156 Short‐LOV 880 386 Pseudomonas agarici P(γ) WP_017130703.1 154 Short‐LOV 881 387 Pseudomonas alcaligenes P(γ) WP_021217027.1 147 Short‐LOV 882 WP_021699549.1 146 Short‐LOV 883 WP_021218606.1 1234 PAS+LOV+2PAS+Kinase+RR 884 388 Pseudomonas alcaliphila P(γ) WP_017678393.1 1274 MASE1+PAS+LOV+GGDEF+EAL 885 389 Pseudomonas amygdali P(γ) WP_010206443.1 452 LOV+Kinase+RR 886 390 Pseudomonas brassicacearum NFM421 P(γ) F2KL83 YP_004356128.1 157 Short‐LOV 887 391 Pseudomonas chlororaphis O6 P(γ) I4XX85 WP_009047027.1 157 Short‐LOV 888 392 Pseudomonas chlororaphis subsp. aureofaciens 30-84 P(γ) J2EWK4 WP_009042217.1 157 Short‐LOV 889 393 Pseudomonas extremaustralis P(γ) WP_010566244.1 155 Short‐LOV 890 394 Pseudomonas fluorescens P(γ) WP_017338856.1 150 Short‐LOV 891 WP_017336579.1 158 Short‐LOV 892 WP_016987018.1 158 Short‐LOV 893 WP_019691929.1 151 Short‐LOV 894 WP_016976173.1 155 Short‐LOV 895 WP_017531111.1 155 Short‐LOV 896 WP_017135085.1 155 Short‐LOV 897 WP_019689251.1 733 RR+2PAS+LOV+GGDEF+EAL 898 Pseudomonas fluorescens A506 P(γ) I2BPA2 YP_006323676.1 525 LOV+Kinase+RR 899 I2BQI5 YP_006325858.1 155 Short‐LOV 900 Pseudomonas fluorescens BBc6R8 P(γ) K1AY44 WP_003208484.1 155 Short‐LOV 901 Pseudomonas fluorescens BRIP34879 P(γ) L7H7A8 WP_003236565.1 524 LOV+Kinase+RR 902 Pseudomonas fluorescens F113 P(γ) G8QB22 YP_005210257.1 157 Short‐LOV 903 Pseudomonas fluorescens PF0-1 P(γ) Q3KHW YP_346628.1 158 Short‐LOV 904 Pseudomonas fluorescens PF-5 P(γ) Q4KI48 YP_258085.1 152 Short‐LOV 905 Pseudomonas fluorescens Q2-87 P(γ) J2F5H6 WP_003178071.1 158 Short‐LOV 906 Pseudomonas fluorescens Q8r1-96 P(γ) I4JY51 YP_004356128.1 157 Short‐LOV 907 Pseudomonas fluorescens R124 P(γ) K0WFQ8 WP_003224839.1 153 Short‐LOV 908 Pseudomonas fluorescens R124 P(γ) K0WYP8 WP_003221745.1 158 Short‐LOV 909 Pseudomonas fluorescens SBW25 P(γ) C3K1W0 YP_002874656.1 155 Short‐LOV 910 Pseudomonas fluorescens SS101 P(γ) I4K663 WP_003194067.1 155 Short‐LOV 911 Pseudomonas fluorescens SS101 P(γ) I4K738 WP_003190461.1 531 LOV+Kinase+RR 912 Pseudomonas fluorescens WH6 P(γ) E2XTK3 WP_003174467.1 519 LOV+Kinase+RR 913 E2XXX1 WP_003176023.1 155 Short‐LOV 914 395 Pseudomonas fragi P(γ) WP_010656027.1 157 Short‐LOV 915 WP_016781829.1 155 Short‐LOV 916 396 Pseudomonas fulva 12-X P(γ) F6ACW6 YP_004473266.1 534 LOV+Kinase+RR 917 F6AEJ4 YP_004473421.1 150 Short‐LOV 918 397 Pseudomonas fuscovaginae P(γ) WP_010452910.1 519 LOV+RR 919 WP_010445203.1 154 Short‐LOV 920 WP_017904260.1 154 Short‐LOV 921 398 Pseudomonas luteola P(γ) WP_019367061.1 1072 RR+PAS+LOV+PAS+GGDEF+EAL+RR 922

A20

399 Pseudomonas mandelii P(γ) WP_010460270.1 150 Short‐LOV 923 WP_010463226.1 159 Short‐LOV 924 WP_019581149.1 158 Short‐LOV 925 400 Pseudomonas mendocina P(γ) WP_017360623.1 1274 MASE1+LOV+2PAS+GGDEF+EAL 926 WP_021487701.1 1274 MASE1+LOV+2PAS+GGDEF+EAL 927 Pseudomonas mendocina DLHK P(γ) J7UFV0 WP_004373223.1 1254 MASE1+LOV+2PAS+GGDEF+EAL 928 J7TJL5 WP_003245955.1 148 Short‐LOV 929 Pseudomonas mendocina NK-01 P(γ) F4DSG2 YP_004381369.1 148 Short‐LOV 930 Pseudomonas mendocina NK-02 P(γ) F4DZM3 YP_004378203.1 1274 MASE1+PAS+LOV+PAS+GGDEF+EAL 931 Pseudomonas mendocina ymp P(γ) A4XP68 YP_001185866.1 1254 MASE1+LOV+2PAS+ GGDEF+EAL 932 P(γ) A4XXH1 YP_001188769.1 148 Short‐LOV 933 401 Pseudomonas monteilii P(γ) WP_016715187.1 148 Short‐LOV 934 402 Pseudomonas nitroreducens P(γ) WP_017519191.1 150 Short‐LOV 935 403 Pseudomonas plecoglossicida NB2011 P(γ) S2JT44 WP_016395429.1 142 Short‐LOV 936 404 Pseudomonas poae RE*1-1-14 P(γ) M4JYC7 YP_007397135.1 524 LOV+Kinase+RR 937 M4K6Y0 YP_007398848.1 155 Short‐LOV 938 405 Pseudomonas protegens CHA0 P(γ) R4RAL1 YP_007998266.1 152 Short‐LOV 939 406 Pseudomonas pseudoalcaligenes CECT 5344 P(γ) I7J111 WP_003462439.1 148 Short‐LOV 940 407 Pseudomonas pseudoalcaligenes KF707 P(γ) L8MD26 WP_003449890.1 1068 RR+2PAS+LOV+GGDEF+EAL 941 L8MMM4 WP_004422222.1 1895 PAS+GAF+PAS+GAF+PAS+LOV+GGDEF+EAL+RR 942 L8MMQ1 WP_003456550.1 148 Short‐LOV 943 408 Pseudomonas psychrophila P(γ) WP_019410857.1 157 Short‐LOV 944 409 Pseudomonas psychrotolerans L19 P(γ) H0JJH7 WP_007162860.1 537 LOV+Kinase+RR 945 H0J8E5 WP_007158985.1 538 LOV+Kinase+RR 946 410 Pseudomonas putida P(γ) WP_019097373.1 148 Short‐LOV 947 WP_019752532.1 142 Short‐LOV 948 WP_021782295.1 148 Short‐LOV 949 WP_021784280.1 142 Short‐LOV 950 Pseudomonas putida (Arthrobacter siderocapsulatus) P(γ) B5SNZ7 148 Short‐LOV 951 Pseudomonas putida BIRD-1 P(γ) E4R4W4 YP_005932103.1 142 Short‐LOV 952 Pseudomonas putida BIRD-2 P(γ) E4RI35 YP_005930752.1 148 Short‐LOV 953 Pseudomonas putida CSV86 P(γ) L1M649 WP_009395102.1 153 Short‐LOV 954 Pseudomonas putida CSV86 P(γ) L1M6G2 WP_009395400.1 532 LOV+Kinase+RR 955 Pseudomonas putida DOT-T1E P(γ) I7C6T3 YP_001269793.1 142 Short‐LOV 956 Pseudomonas putida F1 P(γ) A5W8Z9 YP_001269793.1 142 Short‐LOV 957 A5W4T2 YP_001268326.1 148 Short‐LOV 958 Pseudomonas putida GB-1 P(γ) B0KGV4 YP_001670835.1 142 Short‐LOV 959 Pseudomonas putida group P(γ) WP_016713473.1 142 Short‐LOV 960 Pseudomonas putida H8234 P(γ) R9V1Y1 YP_008094059.1 148 Short‐LOV 961 YP_008097264.1 142 Short‐LOV 962 Pseudomonas putida HB3267 P(γ) L0FJK3 YP_007229131.1 148 Short‐LOV 963 L0FRT1 YP_007231313.1 142 Short‐LOV 964 Pseudomonas putida KT2440 P(γ) Q88E39 NP_746738.1 142 Short‐LOV 965 Q88JB0 NP_744883.1 151 Short‐LOV 966 Pseudomonas putida LS46 P(γ) M7R4B9 YP_001269793.1 142 Short‐LOV 967 M7R1E0 WP_003254000.1 148 Short‐LOV 968 Pseudomonas putida NBRC 14164 P(γ) YP_008113666.1 148 Short‐LOV 969 YP_008111769.1 142 Short‐LOV 970 Pseudomonas putida ND6 P(γ) I3USM9 YP_001269793.1 142 Short‐LOV 971

A21

Pseudomonas putida S11 P(γ) J8RS26 WP_003260703.1 142 Short‐LOV 972 J8RYG9 WP_003257626.1 148 Short‐LOV 973 Pseudomonas putida S16 P(γ) F8G2U7 YP_004701648.1 148 Short‐LOV 974 F8G5Y7 YP_004703866.1 142 Short‐LOV 975 Pseudomonas putida TRO1 P(γ) N9UJ18 YP_001269793.1 142 Short‐LOV 976 N9UCY1 WP_003254000.1 148 Short‐LOV 977 Pseudomonas putida W619 P(γ) B1JAC4 YP_001750029.1 148 Short‐LOV 978 B1J385 YP_001747686.1 152 Short‐LOV 979 411 Pseudomonas resinovorans NBRC 106553 P(γ) S6ANF2 YP_008105095.1 148 Short‐LOV 980 412 Pseudomonas savastanoi pv. savastanoi NCPPB 3335 P(γ) D7HZQ3 WP_002553497.1 534 LOV+Kinase+RR 981 413 Pseudomonas sp. 313 P(γ) WP_017641826.1 501 LOV+Kinase+RR 982 WP_017642205.1 538 LOV+Kinase+RR 983 414 Pseudomonas sp. 45MFCol3.1 P(γ) WP_019647677.1 158 Short‐LOV 984 415 Pseudomonas sp. Ag1 P(γ) J0YEQ9 WP_008432316.1 155 Short‐LOV 985 416 Pseudomonas sp. CBZ-4 P(γ) WP_017735040.1 155 Short‐LOV 986 417 Pseudomonas sp. CF149 P(γ) WP_019824960.1 155 Short‐LOV 987 418 Pseudomonas sp. CF150 P(γ) S6KFW9 WP_020302025.1 155 Short‐LOV 988 WP_020303213.1 510 LOV+Kinase+RR 989 419 Pseudomonas sp. CF161 P(γ) WP_020297180.1 157 Short‐LOV 990 S6J587 WP_020296253.1 300 LOV+GGDEF 991 420 Pseudomonas sp. CFII64 P(γ) S6GUX3 WP_020294427.1 153 Short‐LOV 992 S6HC34 WP_020289714.1 759 GAF+LOV+GGDEF+EAL 993 421 Pseudomonas sp. CFII68 P(γ) S6JL65 WP_018604186.1 157 Short‐LOV 994 422 Pseudomonas sp. CFT9 P(γ) WP_019821480.1 510 LOV+Kinase+RR 995 423 Pseudomonas sp. Chol1 P(γ) K5Y919 WP_008568795.1 148 Short‐LOV 996 424 Pseudomonas sp. EGD-AK9 P(γ) WP_021443742.1 1251 MASE1+LOV+3PAS+GGDEF+EAL 997 WP_021443846.1 145 Short‐LOV 998 425 Pseudomonas sp. G5(2012) P(γ) S2FLS8 WP_020796677.1 154 Short‐LOV 999 426 Pseudomonas sp. GM102 P(γ) J2MPF7 WP_007901653.1 158 Short‐LOV 1000 427 Pseudomonas sp. GM16 P(γ) J2VEZ9 WP_007914248.1 158 Short‐LOV 1001 428 Pseudomonas sp. GM17 P(γ) J2VFQ9 WP_007929819.1 157 Short‐LOV 1002 429 Pseudomonas sp. GM21 P(γ) J2NUZ8 WP_007944641.1 158 Short‐LOV 1003 430 Pseudomonas sp. GM24 P(γ) J2QD44 WP_007914248.1 158 Short‐LOV 1004 431 Pseudomonas sp. GM25 P(γ) J2PQ86 WP_007957219.1 158 Short‐LOV 1005 432 Pseudomonas sp. GM30 P(γ) J2Q414 WP_007968050.1 158 Short‐LOV 1006 433 Pseudomonas sp. GM33 P(γ) J3FZ72 WP_007970313.1 158 Short‐LOV 1007 434 Pseudomonas sp. GM41(2012) P(γ) J2ZFJ0 WP_008150687.1 158 Short‐LOV 1008 435 Pseudomonas sp. GM48 P(γ) J2S6K2 WP_007986762.1 158 Short‐LOV 1009 436 Pseudomonas sp. GM49 P(γ) J3GAS8 WP_008000603.1 158 Short‐LOV 1010 437 Pseudomonas sp. GM50 P(γ) J3GK37 WP_008008657.1 158 Short‐LOV 1011 438 Pseudomonas sp. GM60 P(γ) J2TXN8 WP_008026981.1 158 Short‐LOV 1012 439 Pseudomonas sp. GM67 P(γ) J2UXA4 WP_008037334.1 158 Short‐LOV 1013 440 Pseudomonas sp. GM74 P(γ) J3C1S1 WP_008046230.1 156 Short‐LOV 1014 441 Pseudomonas sp. GM78 P(γ) J2YG82 WP_008054412.1 154 Short‐LOV 1015 442 Pseudomonas sp. GM79 P(γ) J3IFK2 WP_008070532.1 158 Short‐LOV 1016 443 Pseudomonas sp. GM80 P(γ) J3IFB0 WP_008084980.1 158 Short‐LOV 1017 444 Pseudomonas sp. GM84 P(γ) J3E0M0 WP_008096700.1 142 Short‐LOV 1018 445 Pseudomonas sp. HPB0071 P(γ) N2J3H5 WP_010797478.1 558 LOV+Kinase+RR 1019 N2J7R2 WP_010795793.1 566 LOV+Kinase+RR 1020

A22

N2J7R2 WP_010795793.1 566 LOV+Kinase+RR 1021 446 Pseudomonas sp. HYS P(γ) WP_010223533.1 153 Short‐LOV 1022 447 Pseudomonas sp. Lz4W P(γ) M5QYU4 WP_003439967.1 157 Short‐LOV 1023 448 Pseudomonas sp. M47T1 P(γ) I4N1D2 WP_008371185.1 152 Short‐LOV 1024 449 Pseudomonas sp. PAMC 25886 P(γ) WP_010176982.1 155 Short‐LOV 1025 450 Pseudomonas sp. PAMC 26793 P(γ) WP_017479546.1 145 Short‐LOV 1026 451 Pseudomonas sp. PAMC 26793 P(γ) WP_017476025.1 155 Short‐LOV 1027 452 Pseudomonas sp. S9 P(γ) WP_010486409.1 152 Short‐LOV 1028 453 Pseudomonas sp. UW4 P(γ) K9NJA7 YP_007029976.1 148 Short‐LOV 1029 K9NEI7 YP_007027827.1 156 Short‐LOV 1030 454 Pseudomonas sp.TJI-51 P(γ) F0EAJ0 WP_009685517.1 382 LOV+Kinase 1031 F0E265 WP_009682668.1 142 Short‐LOV 1032 F0EAK5 WP_009685532.1 148 Short‐LOV 1033 455 Pseudomonas stutzeri P(γ) WP_019339020.1 148 Short‐LOV 1034 WP_021206844.1 148 Short‐LOV 1035 Pseudomonas stutzeri A1501 P(γ) A4VKZ3 YP_001172486.1 146 Short‐LOV 1036 Pseudomonas stutzeri CCUG 29243 P(γ) I4CTM3 YP_006457853.1 146 Short‐LOV 1037 Pseudomonas stutzeri DSM 4166 P(γ) F2MYU4 YP_005938635.1 146 Short‐LOV 1038 Pseudomonas stutzeri DSM 5190 P(γ) F8H9C5 YP_004714236.1 148 Short‐LOV 1039 Pseudomonas stutzeri KOS6 P(γ) K6CEY0 WP_003296418.1 1064 RR+2PAS+LOV+GGDEF+EAL 1040 Pseudomonas stutzeri NF13 P(γ) M2UPJ8 WP_003300039.1 146 Short‐LOV 1041 Pseudomonas stutzeri RCH2 P(γ) L0GJI2 YP_007240543.1 148 Short‐LOV 1042 Pseudomonas stutzeri TS44 P(γ) I4JMH9 WP_003287724.1 148 Short‐LOV 1043 456 Pseudomonas synxantha BG33R P(γ) I4L697 WP_005791275.1 155 Short‐LOV 1044 457 Pseudomonas syringae P(γ) WP_010432789.1 534 LOV+RR 1045 WP_010404642.1 259 LOV+Kinase 1046 WP_017279143.1 502 LOV+Kinase+RR 1047 WP_017702380.1 502 LOV+Kinase+RR 1048 WP_017709231.1 502 LOV+Kinase+RR 1049 WP_019334300.1 502 LOV+Kinase+RR 1050 WP_020322550.1 534 LOV+Kinase+RR 1051 WP_020304842.1 534 LOV+Kinase+RR 1052 WP_020340339.1 500 LOV+Kinase+RR 1053 WP_020354720.1 534 LOV+Kinase+RR 1054 WP_017703627.1 502 LOV+Kinase+RR 1055 WP_017683368.1 534 LOV+Kinase+RR 1056 Pseudomonas syringae BRIP34876 P(γ) L7FTW7 WP_003426528.1 534 LOV+Kinase+RR 1057 L7FQF5 WP_003429130.1 647 LOV+PAS+Kinase+RR 1058 Pseudomonas syringae BRIP34881 P(γ) L7G1B0 WP_003426528.1 534 LOV+Kinase+RR 1059 L7GCE7 WP_003429130.1 647 LOV+PAS+Kinase+RR 1060 Pseudomonas syringae BRIP39023 P(γ) L7GTP5 WP_003435337.1 502 LOV+Kinase+RR 1061 Pseudomonas syringae Cit 7 P(γ) F3H4Y3 WP_003370902.1 266 LOV+Kinase 1062 458 Pseudomonas syringae pv. aceris str.M302273PT P(γ) F3JEE1 WP_003401108.1 502 LOV+Kinase+RR 1063 459 Pseudomonas syringae pv. actinidiae ICMP 19068 P(γ) S6P6T0 WP_003379535.1 534 LOV+Kinase+RR 1064 Pseudomonas syringae pv. actinidiae ICMP 19070 P(γ) S6R1K7 WP_003379535.1 534 LOV+Kinase+RR 1065 Pseudomonas syringae pv. actinidiae ICMP 19071 P(γ) S6MK99 WP_003379535.1 534 LOV+Kinase+RR 1066 Pseudomonas syringae pv. actinidiae ICMP 19072 P(γ) S6N632 WP_003379535.1 534 LOV+Kinase+RR 1067 Pseudomonas syringae pv. actinidiae ICMP 19103 P(γ) S6MYJ2 WP_003379535.1 534 LOV+Kinase+RR 1068 Pseudomonas syringae pv. actinidiae ICMP 19104 P(γ) S6PWM6 WP_003379535.1 534 LOV+Kinase+RR 1069

A23

Pseudomonas syringae pv. actinidiae ICMP 9855 P(γ) S6SDG5 WP_003379535.1 534 LOV+Kinase+RR 1070 Pseudomonas syringae pv. Actinidiae str.M302091 P(γ) F3I1F9 WP_003379535.1 534 LOV+Kinase+RR 1071 460 Pseudomonas syringae pv. aesculi str. 0893_23 P(γ) F3DLV WP_005730386.1 446 LOV+Kinase+RR 1072 461 Pseudomonas syringae pv. avellanae str. ISPaVe013 P(γ) K2TLM0 WP_003410607.1 502 LOV+Kinase+RR 1073 K2TFJ1 WP_003416783.1 534 LOV+Kinase+RR 1074 462 Pseudomonas syringae pv. glycinea str. B076 P(γ) E7P672 /WP_004662206.1 534 LOV+Kinase+RR 1075 Pseudomonas syringae pv. glycinea str. race 4 P(γ) E7PNY8 WP_004662206.1 534 LOV+Kinase+RR 1076 463 Pseudomonas syringae pv. japonica str. M301072PT P(γ) F3FF68 WP_003314892.1 534 LOV+Kinase 1077 464 Pseudomonas syringae pv. maculicola str. ES4326 P(γ) F3HHL5 WP_007249531.1 534 LOV+Kinase+RR 1078 F3HHL5 WP_007249531.1 534 LOV+Kinase+RR 1079 465 Pseudomonas syringae pv. mori str. 301020 P(γ) F3F0F6 WP_005757687.1 254 LOV+Kinase 1080 466 Pseudomonas syringae pv. morsprunorum str. M302280PT P(γ) F3DZS WP_005739418.1 534 LOV+Kinase 1081 467 Pseudomonas syringae pv. oryzae str. 1_6 P(γ) F2ZCS WP_005886808.1 534 LOV+Kinase+RR 1082 468 Pseudomonas syringae pv. phaseolicola 1448A P(γ) Q48IV1 YP_274680.1 507 LOV+Kinase+RR 1083 469 Pseudomonas syringae pv. pisi str. 1704B P(γ) F3GB29 WP_003344947.1 534 LOV+Kinase 1084 470 Pseudomonas syringae pv. syringae B64 P(γ) L8NFV2 WP_003426528.1 534 LOV+Kinase+RR 1085 Pseudomonas syringae pv. syringae B728a P(γ) Q4ZSY3 YP_235777.1 534 LOV+Kinase+RR 1086 471 Pseudomonas syringae pv. tabaci ATCC 11528 P(γ) F3JTS8 WP_005777149.1 534 LOV+Kinase+RR 1087 472 Pseudomonas syringae pv. theae ICMP 3923 P(γ) S6P4Z2 WP_003379535.1 534 LOV+Kinase+RR 1088 473 Pseudomonas syringae pv. tomato DC3000 P(γ) Q881J7 NP_792694.1 534 LOV+Kinase+RR 1089 Pseudomonas syringae pv. tomato T1 P(γ) E2M7Z9 EEB61765.1/NP_792694.1 534 LOV+Kinase 1090 474 Pseudomonas tolaasii P(γ) WP_017254000.1 155 Short‐LOV 1091 WP_016971065.1 155 Short‐LOV 1092 475 Pseudomonas veronii P(γ) WP_017847767.1 155 Short‐LOV 1093 476 Pseudomonas viridiflava UASWS0038 P(γ) K6BMA6 WP_004885117.1 151 Short‐LOV 1094 K6BTG2 WP_004882331.1 503 LOV+Kinase+RR 1095 477 Rheinheimera sp. A13L P(γ) F7P0A2 WP_008900325.1 1195 RR+GAF+PAS+LOV+GGDEF+EAL 1096 478 Rhodanobacter fulvus Jip2 P(γ) I4VRA7 WP_007081336.1 813 RR+PAS+LOV+GGDEF+EAL 1097 479 Rhodobacter sphaeroides WS8N P(γ) F5M2M2 WP_002719387.1 176 Short‐LOV 1098 480 Salinisphaera shabanensis E1L3A P(γ) F7QDZ2 WP_006915464.1 333 LOV+GGDEF 1099 481 Serratia fonticola P(γ) WP_021805398.1 310 LOV+GGDEF 1100 482 Serratia plymuthica AS9 P(γ) G0B7B1 YP_004500367.1 310 LOV+GGDEF 1101 483 Serratia sp.AS12 P(γ) G0BP57 /YP_004500367.1 310 LOV+GGDEF 1102 484 Serratia sp.AS13 P(γ) G0C2A2 /YP_004500367.1 310 LOV+GGDEF 1103 485 Shewanella baltica BA175 P(γ) G0AVH5 YP_006022696.1 1215 MASE+CHASE+PAS+LOV+GGDEF+EAL 1104 Shewanella baltica OS 117 P(γ) G0DM57 YP_006035465.1 1215 MASE+CHASE+PAS+LOV+GGDEF+EAL 1105 Shewanella baltica OS 183 P(γ) H1YLW6 EHQ13065.1/YP_006022696.1 1215 MASE+CHASE+PAS+LOV+GGDEF+EAL 1106 Shewanella baltica OS185 P(γ) A6WU43 YP_001368395.1 1215 MASE1+CHASE+PAS+LOV+GGDEF+EAL 1107 Shewanella baltica OS223 P(γ) B8ECQ3 YP_002360038.1 1215 MASE1+CHASE+PAS+LOV+GGDEF+EAL 1108 486 Shewanella oneidensis MR-1 P(γ) K4PU33 YP_007001418.1 1181 MASE1+CHASE+PAS+LOV+GGDEF+EAL 1109 487 Shewanella putrefaciens CN-32 P(γ) A4YC79 YP_001185361.1 1216 MASE1+CHASE+PAS+LOV+GGDEF+EAL 1110 488 Shewanella sp. ANA-3 P(γ) A0L2H7 YP_871652.1 1228 MASE1+CHASE+PAS+LOV+GGDEF+EAL 1111 489 Shewanella sp. HN_41 P(γ) F7RU72 WP_007652082.1 1209 MASE+CHASE+PAS+LOV+GGDEF+EAL 1112 490 Shewanella sp. W3-18-1 P(γ) A1RE55 YP_961504.1 1216 MASE1+CHASE+PAS+LOV+GGDEF+EAL 1113 491 Sphingomonas elodea P(γ) WP_010545260.1 186 Short‐LOV 1114 492 Spiribacter salinus M19-40 P(γ) R4VQP9 YP_008047228.1 151 Short‐LOV 1115 493 Thalassolituus oleivorans MIL-1 P(γ) M5DNS9 YP_007681337.1 155 Short‐LOV 1116 494 Thioalkalimicrobium aerophilum AL3 P(γ) G4D8R7 WP_006459544.1 147 Short‐LOV 1117 495 Thioalkalimicrobium cyclicum DSM 14477 P(γ) F6D9J9 YP_004536435.1 148 Short‐LOV 1118

A24

496 Thioalkalivibrio P(γ) WP_019024324.1 147 Short‐LOV 1119 WP_018864256.1 147 Short‐LOV 1120 WP_018139391.1 147 Short‐LOV 1121 WP_018174373.1 147 Short‐LOV 1122 WP_018861429.1 147 Short‐LOV 1123 WP_018650214.1 143 Short‐LOV 1124 WP_018169641.1 143 Short‐LOV 1125 WP_018867397.1 130 Short‐LOV 1126 WP_018877756.1 130 Short‐LOV 1127 WP_017942490.1 143 Short‐LOV 1128 WP_018140537.1 143 Short‐LOV 1129 WP_019589553.1 143 Short‐LOV 1130 WP_018870567.1 143 Short‐LOV 1131 497 Thioalkalivibrio nitratireducens DSM 14787 P(γ) L0DYC1 YP_007218080.1 150 Short‐LOV 1132 498 Thioalkalivibrio sp. AKL11 P(γ) WP_018939800.1 147 Short‐LOV 1133 499 Thioalkalivibrio sp. AKL12 P(γ) WP_018951723.1 143 Short‐LOV 1134 500 Thioalkalivibrio sp. AKL17 P(γ) WP_018947690.1 143 Short‐LOV 1135 501 Thioalkalivibrio sp. AKL6 P(γ) WP_018145821.1 143 Short‐LOV 1136 502 Thioalkalivibrio sp. ALE23 P(γ) WP_019022854.1 609 MASE1+LOV+GGDEF 1137 503 Thioalkalivibrio sp. ALE31 P(γ) WP_018875372.1 130 Short‐LOV 1138 504 Thioalkalivibrio sp. ALJ15 P(γ) WP_020146677.1 147 Short‐LOV 1139 505 Thioalkalivibrio sp. ALJ16 P(γ) WP_018872447.1 143 Short‐LOV 1140 506 Thioalkalivibrio sp. ALJ17 P(γ) WP_018953828.1 1218 RR+PAS+GAF+LOV+2PAS+Kinase+RR 1141 507 Thioalkalivibrio sp. ALJ24 P(γ) WP_018936177.1 147 Short‐LOV 1142 WP_018936260.1 625 MASE1+LOV+GGDEF 1143 508 Thioalkalivibrio sp. ALJT P(γ) WP_019626073.1 143 Short‐LOV 1144 509 Thioalkalivibrio sp. ALMg11 P(γ) WP_018949625.1 143 Short‐LOV 1145 510 Thioalkalivibrio sp. ALSr1 P(γ) WP_019643012.1 143 Short‐LOV 1146 WP_019643090.1 639 MASE1+LOV+GGDEF 1147 511 Thioalkalivibrio sp. HL-Eb18 P(γ) WP_017926630.1 147 Short‐LOV 1148 512 Thioalkalivibrio sp. HL-EbGR7 P(γ) B8GRG0 YP_002513501.1 148 Short‐LOV 1149 513 Thioalkalivibrio sp. K90mix P(γ) D3S9U5 YP_003460536.1 147 Short‐LOV 1150 514 Thioalkalivibrio thiocyanoxidans ARh4 P(γ) G4DMF8 WP_006749018.1 150 Short‐LOV 1151 515 Thiocapsa marina5811 P(γ) F9U8V WP_007192233.1 153 Short‐LOV 1152 516 Thiocystis violascens ATCC 17096 P(γ) I3Y8C2 YP_006413365.1 515 LOV+PAS+Kinase 1153 517 Thioflavicoccus mobilis 8321 P(γ) L0GV52 YP_007243337.1 155 Short‐LOV 1154 518 Thiomicrospira denitrificans ATCC 33889 P(γ) Q30NS0 YP_394596.1 240 HTH+ LOV 1155 519 Thiomicrospira halophila P(γ) WP_019895319.1 151 Short‐LOV 1156 520 Thiorhodospira sibirica ATCC 700588 P(γ) G4E1Z1 WP_006786321.1 1042 LOV+4PAS+Kinase+RR 1157 521 Thiorhodovibrio sp. 970 P(γ) H8Z429 WP_009150501.1 155 Short‐LOV 1158 522 Thiothrix nivea DSM 5205 P(γ) I3BYI4 WP_002710300.1 158 Short‐LOV 1159 523 Vibrio alginolyticus NBRC 15630 = ATCC 17749 P(γ) YP_008535342.1 1595 HAMP+PAS+LOV+2PAS+Kinase+RR+Hpt 1160 524 Vibrio fischeri ATCC 700601 P(γ) Q5E662 YP_204372.1 631 LOV+GGDEF 1161 Vibrio fischeri MJ11 P(γ) B5FD75 YP_002155793.1 631 LOV+GGDEF 1162 Vibrio fischeri SR5 P(γ) H1QYA1 WP_005418693.1 631 LOV+GGDEF 1163 525 Vibrio parahaemolyticus 16 P(γ) B8KBV9 WP_005474670.1 1594 HAMP+PAS+LOV+2PAS+Kinase+RR+Hpt 1164 526 Vibrio proteolyticus P(γ) WP_021706469.1 1600 HAMP+PAS+LOV+2PAS+Kinase+RR+Hpt 1165 527 Xanthomonas albilineans GPE PC73 P(γ) D2UAU2 YP_003376125.1 544 LOV+Kinase+RR 1166 528 Xanthomonas arboricola P(γ) WP_016902009.1 520 LOV+Kinase+RR 1167

A25

529 Xanthomonas axonopodis P(γ) WP_016851550.1 540 LOV+Kinase+RR 1168 WP_017173235.1 356 LOV+Kinase 1169 WP_017161173.1 334 LOV+Kinase 1170 WP_017159283.1 540 LOV+Kinase+RR 1171 WP_017157089.1 540 LOV+Kinase+RR 1172 530 Xanthomonas axonopodis pv. citri str.306 P(γ) Q8PJH NP_642870.1 540 LOV+Kinase+RR 1173 531 Xanthomonas axonopodis pv. citrumelo F1 P(γ) G2LWN4 YP_004852094.1 540 LOV+Kinase+RR 1174 532 Xanthomonas axonopodis pv. malvacearum str. GSPB1386 P(γ) K8GB13 WP_005914055.1 540 LOV+Kinase+RR 1175 Xanthomonas axonopodis pv. malvacearum str. GSPB2388 P(γ) K8G4G5 WP_005914055.1 540 LOV+Kinase+RR 1176 533 Xanthomonas axonopodis pv. punicae str. LMG 859 P(γ) H1XH4 WP_005929141.1 540 LOV+Kinase+RR 1177 534 Xanthomonas campestris P(γ) WP_010378213.1 541 LOV+Kinase+RR 1178 535 Xanthomonas campestris pv campestris 8004 P(γ) Q4UW16 YP_242777.1/NP_637775.1 540 LOV+Kinase+RR 1179 Xanthomonas campestris pv campestris ATCC 33913 P(γ) Q8P827 NP_637775.1 540 LOV+Kinase+RR 1180 Xanthomonas campestris pv. campestris B100 P(γ) B0RRL1 YP_001903150.1 540 LOV+Kinase+RR 1181 536 Xanthomonas campestris pv. raphani 756C P(γ) G0CI52 YP_005637715.1 540 LOV+Kinase+RR 1182 537 Xanthomonas campestris pv. vesicatoria 85-10 P(γ) Q3BRX8 YP_364485.1 540 LOV+Kinase+RR 1183 538 Xanthomonas citri pv. mangiferaeindicae LMG 941 P(γ) H8FDX1 WP_003484907.1 502 LOV+Kinase+RR 1184 539 Xanthomonas citri subsp. citri Aw12879 P(γ) M4VYP7 YP_007650222.1 540 LOV+Kinase+RR 1185 540 Xanthomonas fuscans subsp. aurantifolii str. ICPB 10535 P(γ) D4TB06 WP_007965960.1 540 LOV+Kinase+RR 1186 Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122 P(γ) D4SVY4 WP_007965960.1 540 LOV+Kinase+RR 1187 541 Xanthomonas gardneri ATCC 19865 P(γ) F0C005 WP_006448485.1 180 Short‐LOV 1188 542 Xanthomonas oryzae P(γ) WP_019299959.1 507 LOV+Kinase+RR 1189 543 Xanthomonas oryzae pv. oryzae MAFF 311018 P(γ) Q2P13 YP_452017.1 540 LOV+Kinase+RR 1190 Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85) P(γ) Q5GY20 YP_201786.1 428 LOV+Kinase 1191 Xanthomonas oryzae pv. oryzae PXO99A P(γ) B2SUI2 YP_001914487.1 507 LOV+Kinase+RR 1192 544 Xanthomonas oryzae pv. oryzicola BLS256 P(γ) G7TAT9 YP_005628219.1 502 LOV+Kinase+RR 1193 545 Xanthomonas perforans 91-118 P(γ) F0BMJ4 WP_008571382.1 540 LOV+Kinase+RR 1194 546 Xanthomonas sacchari P(γ) WP_010342969.1 544 LOV+Kinase+RR 1195 547 Xanthomonas sp. SHU199 P(γ) WP_017907883.1 544 LOV+Kinase+RR 1196 548 Xanthomonas sp. SHU308 P(γ) WP_017914963.1 544 LOV+Kinase+RR 1197 549 Xanthomonas translucens DAR61454 P(γ) L7FSH1 WP_003473017.1 542 LOV+Kinase+RR 1198 550 Xanthomonas translucens pv. graminis ART-Xtg29 P(γ) K8ZG10 WP_009602159.1 542 LOV+Kinase+RR 1199 551 Xanthomonas translucens pv. translucens DSM 18974 P(γ) L0SUV4 WP_003474558.1 542 LOV+Kinase+RR 1200 552 Xanthomonas vasicola P(γ) WP_010363479.1 541 LOV+Kinase+RR 1201 WP_017116448.1 508 LOV+Kinase+RR 1202 553 Xanthomonas vesicatoria ATCC 35937 P(γ) F0BB91 WP_005990538.1 519 LOV+Kinase+RR 1203 554 Chloroflexus aggregans DSM 9485 Chl B8GAY9 YP_002465025.1 913 LOV+PAS+PAS+Kinase+RR 1204 555 Chloroflexus aurantiacus ATCC 29364 Chl B9LBT8 YP_002571059.1/YP_001636696.1 915 LOV +2PAS +Kinase+RR+Hpt 1205 Chloroflexus aurantiacus J-10-fl Chl A9WHI1 YP_001636696.1 915 LOV +2PAS+Kinase+RR+Hpt 1206 556 Chloroherpeton thalassium ATCC35110 Chl B3QS59 YP_001996451.1 1333 3PAS+LOV+GAF+PAS+Kinase+RR 1207 557 Herpetosiphon aurantiacus ATCC 23779 Chl A9B1I0 YP_001543993.1 1877 HAMP+GAF+LOV+4PAS+GAF+Kinase 1208 558 Acaryochloris marina MBIC 11017 Cya B0C6M6 YP_001515761.1 935 PAS+LOV+2PAS+GGDEF+EAL 1209 559 Acaryochloris sp. CCMEE 5410 Cya WP_010476320.1 912 2PAS+LOV+PAS+GGDEF+EAL 1210 560 Anabaena variabilis ATCC 29413 Cya Q3M6B3 YP_324368.1 1021 LOV+2PAS+GGDEF+EAL 1211 Q3MED3 YP_321548.1 1820 PAS+LOV+3PAS+GAF+Kinase+ 2RR+Hpt 1212 561 Arthrospira maxima CS-328 Cya B5W5T2 WP_006625197.1 1276 PAS+GAF+PAS+GAF+LOV+GGDEF+EAL 1213 B5VY09 WP_006668677.1 1184 GAF+PAS+LOV+PAS+GAF+Kinase 1214 562 Arthrospira platensis C1 Cya K1W4H5 WP_006625197.1 1276 PAS+GAF+LOV+GGDEF+EAL 1215 K1X4B3 WP_006624369.1 1240 GAF+PAS+LOV+PAS+Kinase 1216

A26

K1W3R6 WP_006625388.1 452 RR+LOV+GGDEF 1217 563 Arthrospira platensis NIES-39 Cya D5A2C5 YP_005067517.1 501 RR+LOV+GGDEF 1218 D5A3S6 YP_005067758.1 1276 PAS+GAF+LOV+GAF+GGDEF+EAL 1219 D5A1P6 YP_005071467.1 1240 GAF+2PAS+LOV+GAF+Kinase 1220 564 Arthrospira platensis str. Paraca Cya K6DZN7 WP_006618143.1 502 RR+LOV+GGDEF 1221 K6DYP8 WP_006618516.1 1276 PAS+GAF+PAS+GAF+LOV+GGDEF+EAL 1222 K6DR83 WP_006616930.1 1240 GAF+PAS+LOV+PAS+Kinase 1223 565 Arthrospira sp. PCC 8005 Cya H1WBC0 WP_008051195.1 542 RR+LOV+GGDEF 1224 H1WBU5 WP_008051404.1 1279 PAS+GAF+LOV+GAF+PAS+EAL 1225 H1WDU3 WP_008052387.1 1240 GAF+2LOV+PAS+2GAF+Kinase 1226 566 Chlorogloeopsis Cya WP_016873643.1 917 PAS+LOV+PAS+GGDEF+EAL 1227 WP_016876159.1 1301 PAS+LOV+3PAS+Kinase 1228 567 Crinalium epipsammum PCC 9333 Cya K9VUA3 YP_007140547.1 973 LOV+GAF+Kinase 1229 K9VVG0 YP_007141588.1 811 LOV+PAS+GAF+Kinase 1230 568 Crocosphaera watsonii Cya WP_021836924.1 274 RR+LOV 1231 WP_021831117.1 222 RR+LOV 1232 Crocosphaera watsonii WH 8501 Cya Q4BW45 WP_007308072.1 297 RR+LOV 1233 Crocosphaera watsonii WH 0003 Cya G5JC80 WP_007312830.1 483 RR+LOV+GGDEF 1234 569 Cyanobacterium aponinum PCC 10605 Cya K9Z5T6 YP_007162595.1 1220 LOV+GAF+2PAS+GGDEF+EAL 1235 570 Cyanothece ATCC 51142 Cya B1WPX1 YP_001805352.1 483 RR+LOV+GGDEF 1236 Cyanothece PCC 8801/ Synechococcus sp. PCC 8801 Cya B7JZ07 YP_002372240.1 481 RR+LOV+GGDEF 1237 Cyanothece sp. CCY0110 Cya A3IMW4 WP_008274722.1 483 RR+LOV+GGDEF 1238 Cyanothece sp. PCC 8802 Cya C7QX31 YP_003137799.1 481 RR+LOV+GGDEF 1239 Cyanothece sp.ATCC51472 Cya G6GZ93 EHC21269.1/YP_001805352.1 483 RR+LOV+GGDEF 1240 571 Cylindrospermum stagnale PCC 7417 Cya K9WTZ1 YP_007146338.1 2260 cbs+3PAS+GAF+LOV+Kinase 1241 572 filamentous cyanobacterium ESFC-1 Cya WP_018397868.1 1587 GAF+LOV+5PAS+GGDEF+EAL 1242 WP_018398448.1 1504 cbs+GAF+3PAS+LOV+3PAS+Kinase 1243 WP_018398453.1 1047 GAF+3PAS+LOV+PAS+Kinase 1244 573 Fischerella muscicola Cya WP_016869711.1 1013 CBS+3PAS+LOV+PAS+Kinase 1245 WP_016859885.1 803 CBS+LOV+PAS+Kinase 1246 574 Geitlerinema sp. PCC 7105 Cya WP_017659770.1 1803 2PAS+GAF+6PAS+LOV+2PAS+Kinase 1247 575 Geitlerinema sp. PCC 7407 Cya K9S9T8 YP_007110030.1 1135 2PAS+GAF+LOV+PAS+GGDEF+EAL 1248 576 Geminocystis herdmanii Cya WP_017295851.1 1249 LOV+GAF+2PAS+GGDEF+EAL 1249 577 Gloeocapsa sp. PCC 73106 Cya L8LH99 WP_006530862.1 1137 GAF+LOV+2PAS+GGDEF+EAL 1250 578 Halothece sp. PCC 7418 (Synechococcus sp. (strain PCC 7418)) Cya K9YDF6 YP_007168649.1 731 LOV+PAS+GGDEF+EAL 1251 579 Leptolyngbya sp. PCC 7376 Cya K9Q326 YP_007072303.1 1052 GAF+LOV+PAS+GGDEF+EAL 1252 580 Lyngbya sp. PCC 8106 Cya A0YVI7 WP_009786481.1 477 RR+LOV+GGDEF 1253 A0YYE1 WP_009787479.1 1090 PAS+LOV+PAS+GGDEF+EAL 1254 A0YS28 WP_009785277.1 1261 RR+RR+LOV+PAS+GAF+Kinase+RR 1255 A0YI13 WP_009782119.1 1006 PAS+LOV+3PAS+GAF+GGDEF 1256 A0YJV6 WP_009782762.1 1211 GAF+PAS+LOV+PAS+GAF+Kinase 1257 A0YYE8 WP_009787486.1 990 PAS+GAF+LOV+GGDEF+EAL 1258 581 Mastigocladopsis repens Cya WP_017316340.1 897 MHYT+GAF+LOV+MCP 1259 WP_017315856.1 1497 CBS+LOV+4PAS+Kinase 1260 WP_017315856.1 1497 CBS+LOV+4PAS+Kinase 1261 582 Microchaete sp. PCC 7126 Cya WP_017651577.1 1069 cbs+PAS+GAF+2PAS+LOV+GAF+Kinase 1262 583 Microcoleus chthonoplastes PCC 7420 Cya B4VK29 WP_006098908.1 2020 2PAS+LOV+4PAS+2GAF+Kinase+ 2RR 1263 B4VKN6 WP_006099135.1 483 PAS+LOV+Cyclase 1264 B4VSY1 WP_006101616.1 1145 RR+GAF+LOV+2PAS+GAF+Kinase 1265 B4VJB8 WP_006098397.1 776 LOV+GAF+Kinase 1266

A27

B4VY11 WP_006103549.1 1393 2PAS+GAF+LOV+2PAS+GGDEF+EAL 1267 584 Microcoleus sp. PCC 7113 Cya K9WJW9 YP_007124111.1 880 LOV+PAS+Kinase+RR 1268 K9WIF3 YP_007123389.1 1204 RR+3PAS+LOV+GAF+Kinase 1269 K9WFV8 YP_007122711.1 483 LOV+PAS+GGDEF 1270 K9W9I5 YP_007120451.1 494 RR+LOV+GGDEF 1271 K9WEP7 YP_007122079.1 929 PAS+LOV+PAS+GAF+Kinase 1272 K9WK80 YP_007123343.1 621 RR+LOV+Kinase 1273 585 Microcoleus vaginatus FGP-2 Cya F5UCI6 WP_006631032.1 1102 LOV+4PAS+Kinase 1274 F5UNN6 WP_006635552.1 1113 LOV+4PAS+GAF+Kinase 1275 F5UBU5 WP_006631635.1 1024 LOV+4PAS+GGDEF+EAL 1276 F5UC68 WP_006631762.1 1375 PAS+GAF+LOV+GAF+PAS+2EAL 1277 586 Nodosilinea nodulosa Cya WP_017296958.1 834 GAF+LOV+Kinase+RR+Hpt 1278 587 Nostoc punctiforme PCC 73102 Cya B2JAQ5 YP_001870050.1 1043 LOV+2PAS+GGDEF+EAL 1279 B2J8F4 YP_001865874.1 1403 PAS+LOV+PAS+GAF+Kinase+2RR+Hpt 1280 588 Nostoc sp. ATCC 29411 Cya K9QZN6 YP_007078500.1 1019 LOV+2PAS+GGDEF+EAL 1281 589 Nostoc sp. ATCC 29412 Cya K9QT62 YP_007076412.1 1712 CHASE+PAS+LOV+PAS+GAF+Kinase+RR+HPT 1282 590 Nostoc sp. PCC 7107 Cya K9QBD4 YP_007049843.1 1567 CHASE+PAS+LOV+PAS+GAF+Kinase+RR+HPT 1283 591 Nostoc sp. PCC 7120 Cya Q8YSB9 NP_487210.1 1021 LOV+2PAS+GGDEF+EAL 1284 Q8YT51 NP_486915.1 1817 PAS+LOV+3PAS+GAF+Kinase+ 2RR+Hpt 1285 592 Oscillatoria acuminata PCC 6304 Cya K9TPZ8 YP_007088398.1 1288 PAS+GAF+2PAS+LOV+GGDEF+EAL 1286 593 Oscillatoria formosa Cya WP_019486854.1 1518 2PAS+GAF+PAS+GAF+LOV+GGDEF+EAL 1287 594 Oscillatoria nigro-viridis PCC 7112 Cya K9VLB1 YP_007117299.1 1344 PAS+GAF+LOV+PAS+GGDEF+EAL 1288 K9VF92 YP_007114341.1 1003 LOV+3PAS+GGDEF+EAL 1289 K9VJW6 YP_007115936.1 1113 LOV+4PAS+GAF+Kinase 1290 K9VDJ7 YP_007114659.1 1102 LOV+2PAS+Kinase 1291 595 Oscillatoria sp. PCC 10802 Cya WP_017717108.1 1992 RR+2PAS+LOV+6PAS+GAF+Kinase+RR 1292 596 Oscillatoria sp.PCC6506 Cya D8FYX WP_007354786.1 631 PAS+LOV+Kinase 1293 D8G8N3 WP_007358144.1 1041 LOV+GAF+PAS+GGDEF+2EAL 1294 D8FU68 WP_007353135.1 1432 GAF+LOV+PAS+LOV+PAS+2GAF+Kinase 1295 D8G759 WP_007357627.1 1140 LOV+3PAS+GGDEF+2EAL 1296 597 Pleurocapsa sp. PCC 7327 Cya K9T9F1 YP_007082610.1 479 RR+LOV+GGDEF 1297 598 Pseudanabaena biceps PCC 7429 Cya L8MY36 WP_009626941.1 1179 PAS+LOV+GAF+Kinase+RR+HpT 1298 L8MXD6 WP_009628448.1 945 PAS+LOV+PAS+GAF+Kinase 1299 599 Pseudanabaena sp. PCC 6802 Cya WP_019500070.1 935 LOV+2PAS+Kinase 1300 WP_019498621.1 737 RR+PAS+LOV+Kinase 1301 600 Scytonema hofmanni Cya WP_017745401.1 930 MHYT+GAF+LOV+HAMP+MCP 1302 WP_017746529.1 883 GAF+LOV+PAS+GGDEF+EAL 1303 WP_017740454.1 949 CBS+LOV+PAS+Kinase 1304 WP_017744138.1 931 MHYT+GAF+LOV+HAMP+MCP 1305 WP_017740600.1 923 2RR+LOV+Kinase+RR 1306 601 Spirulina subsalsa Cya WP_017306948.1 1652 RR+LOV+8PAS+Kinase 1307 WP_017305004.1 451 PAS+LOV+GGDEF 1308 602 Synechococcus sp. ATCC 27167 Cya K9RZ52 YP_007063296.1 1154 GAF+PAS+LOV+Kinase+RR 1309 603 Synechococcus sp. PCC 6301 Cya Q5N2F7 YP_172033.1 578 LOV+GGDEF+EAL 1310 Q5N5M8 YP_170910.1 929 RR+PAS+PAS+LOV+ GGDEF+EAL 1311 604 Synechococcus sp. PCC 7002 Cya B1XLQ8 YP_001734607.1 780 GAF+LOV+PAS+GGDEF 1312 605 Synechococcus sp. PCC 7502 Cya K9SZJ8 YP_007107456.1 914 2PAS+LOV+GAF+Kinase 1313 606 Synechococcus sp. PCC 7942 Cya Q31RU9 YP_399207.1 578 LOV+GGDEF+EAL 1314 Q31NI4 YP_400372.1 929 RR+PAS+PAS+LOV+ GGDEF+EAL 1315 607 Synechocystis sp. PCC 6803 Cya L8ARN4 BAM54579.1 1235 GAF+LOV+3PAS+GGDEF+EAL 1316

A28

Q55576 NP_442010.1 1244 GAF+LOV+3PAS+GGDEF+EAL 1317 F7URV3 YP_005652070.1/NP_442010.1 1244 GAF+LOV+3PAS+GGDEF+EAL 1318 608 Synechocystis sp. PCC 6803 substr. PCC-P Cya H0PFN3 YP_005387047.1/NP_442010.1 1244 GAF+LOV+3PAS+GGDEF+EAL 1319 H0PAQ0 YP_005409754.1/NP_442010.1 1244 GAF+LOV+3PAS+GGDEF+EAL 1320 609 Synechocystis sp.PCC 6803 substr. GT-I Cya H0NY98 YP_005383878.1/NP_442010.1 1244 GAF+LOV+3PAS+GGDEF+EAL 1321 610 Thermosynechococcus elongatus BP-1 Cya Q8DJE3 NP_682072.1 1353 GAF+PAS+LOV+2GAF +Kinase+ RR 1322 611 Gemmata obscuriglobus Pl WP_010043508.1 823 PAS+LOV+Kinase+RR 1323 WP_010043417.1 997 RR+2PAS+LOV+PAS+Kinase 1324 WP_010041727.1 1032 2PAS+LOV+PAS+Kinase+RR 1325 WP_010042468.1 1178 2PAS+LOV+PAS+GAF+Kinase+RR 1326 612 planctomycete KSU-1 Pl I3IH21 WP_007220142.1 1155 GAF+LOV+2PAS+Kinase+RR 1327 613 Rhodopirellula baltica SH1 Pl Q7USG5 NP_866145.1 1637 CHEB+CHER+PAS+LOV+PAS+Kinase+ RR 1328 Rhodopirellula baltica SH28 Pl K5DM72 WP_007330973.1 1637 CHER+2PAS+LOV+PAS+Kinase+RR 1329 Rhodopirellula baltica SWK14 Pl L7CQZ7 WP_007335941.1 1637 CHER+2PAS+LOV+PAS+Kinase+RR 1330 Rhodopirellula baltica SWK14 Pl L7C999 WP_007340810.1 1739 CHER+2PAS+LOV+PAS+Kinase+RR 1331 Rhodopirellula baltica WH47 Pl F2B0L3 WP_007329423.1 1637 RR+CHER‐CHERB+3PAS+LOV+Kinase 1332 614 Rhodopirellula europaea 6C Pl M2B329 WP_008657036.1 651 LOV+Kinase 1333 M2AB22 WP_008661450.1 1637 CHER+2PAS+LOV+PAS+Kinase+RR 1334 M2B160 WP_008658004.1 1739 CHER+2PAS+LOV+PAS+Kinase+RR 1335 Rhodopirellula europaea SH398 Pl M5S556 WP_008666956.1 1637 CHER+2PAS+LOV+PAS+Kinase+RR 1336 615 Rhodopirellula maiorica SM1 Pl M5RDE8 WP_008703751.1 1471 CHER+2PAS+LOV+PAS+Kinase+RR 1337 616 Rhodopirellula sallentina SM41 Pl M5U3R2 WP_008678750.1 1752 CHER+2PAS+LOV+PAS+Kinase+RR 1338 617 Rhodopirellula sp. SWK7 Pl M5TB77 WP_009094396.1 1738 CHER+2PAS+LOV+PAS+Kinase+RR 1339 618 Schlesneria paludicola Pl WP_010583390.1 819 PAS+GAF+LOV+Kinase+RR 1340 WP_010587131.1 925 PAS+LOV+Kinase+RR+HPT 1341 619 Zavarzinella formosa Pl WP_020473798.1 660 LOV+Kinase+RR 1342 620 Leptospirillum ferriphilum (strain ML-04) Nit J9Z9K3 YP_006766144.1 1036 GAF+LOV+PAS+GGDEF+EAL 1343 621 Leptospirillum ferrodiazotrophum Nit C6HUQ3 EES53679.1 1354 2PAS+GAF+LOV+GGDEF+Globin 1344 C6HW67 EES53172.1 1369 PAS+2GAF+PAS+LOV+GGDEF+Globin 1345 C6HYK0 EES52285.1 496 PAS+LOV+Kinase 1346 622 Leptospirillum ferrooxidans (strain C2-3) Nit I0IRY1 YP_005470160.1 489 LOV+GGDEF 1347 623 Leptospirillum sp. Group II 'C75' Nit EIJ77392.1 1036 GAF+PAS+LOV+GGDEF+EAL 1348 624 Leptospirillum sp. Group IV 'UBA BS' Nit T0Z8K9 WP_021811090.1 1614 PAS+GAF+PAS+GAF+LOV+GGDEF+EAL 1349 625 Leptospirillum sp. Group II '5-way CG' Nit B6AQW0 EDZ38519.1 1035 GAF+LOV+PAS+GGDEF+EAL 1350 626 Leptospirillum sp. Group II UBA Nit A3ERH5 EAY57303.1 1036 GAF+LOV+PAS+GGDEF+EAL 1351 627 Acidobacterium sp. (strain MP5ACTX9) Bact E8X7C4 YP_004210485.1 519 LOV+Kinase 1352 628 Cellulophaga algicola DSM 14237 Bact E6XF72 YP_004165806.1 628 PAS+LOV+Kinase 1353 E6XEC5 YP_004165713.1 1083 3PAS+LOV+GAF+Kinase 1354 629 Chloroherpeton thalassium ATCC 35110 Bact B3QWA0 YP_001995660.1 190 Short‐LOV 1355 630 Cyclobacterium qasimii M12-11B Bact S7V803 WP_020889873.1 972 2PAS+LOV+GAF+Kinase 1356 631 Eudoraea adriatica Bact WP_019670355.1 631 PAS+LOV+PAS+Kinase 1357 632 Formosa sp. AK20 Bact M7MMR6 WP_007647936.1 809 PAS+LOV+PAS+GAF+Kinase 1358 633 Fulvivirga imtechensis AK7 Bact L8JI64 WP_009583264.1 1336 CHER+PAS+LOV+PAS+Kinase 1359 634 Granulicella mallensis DSM 23137 Bact G8NP03 YP_005058137.1 519 LOV+Kinase 1360 635 Mucilaginibacter paludis DSM 18603 Bact H1Y366 WP_008509841.1 508 LOV+PAS+Kinase 1361 636 Muricauda ruestringensis (strain DSM 13258) Bact G2PRN8 YP_004786909.1 848 PAS+LOV+GAF+Kinase 1362 637 Pedobacter agri Bact WP_010603242.1 517 LOV+PAS+Kinase 1363 638 Pedobacter sp. BAL39 Bact A6E9H1 WP_008239045.1 512 LOV+PAS+Kinase 1364 639 Polaribacter franzmannii Bact WP_018944019.1 836 PAS+LOV+GAF+Kinase 1365 640 Sphingobacterium sp. (strain 21) Bact F4CCK0 YP_004320289.1 520 LOV+PAS+Kinase 1366

A29

641 Sphingobacterium sp. IITKGP-BTPF85 Bact T0MYW2 WP_021188605.1 282 LOV+PAS 1367 642 Zobellia galactanivorans strain DSM 12802 Bact G0L288 YP_004738261.1 1092 3PAS+LOV+GAF+PAS+Kinase 1368 643 Deinococcus apachensis DeTh WP_019586595.1 285 LOV+GGDEF 1369 644 Deinococcus peraridilitoris strain DSM 19664 DeTh L0A6T3 YP_007174032.1 297 LOV+GGDEF 1370 645 Meiothermus ruber ATCC 35948 DeTh D3PRD8 YP_003507041.1 578 LOV+2PAS+Kinase 1371 646 Truepera radiovictrix DSM 17093 DeTh D7CV48 YP_003706418.1 465 LOV+PAS+Kinase 1372 647 Sulfuricurvum kujiense DSM 16994 P(ε) E4U216 YP_004060773.1 730 LOV+PDEase/HD 1373 E4U0K3 YP_004060520.1 568 PAS+LOV+GGDEF 1374 E4U0H9 YP_004060496.1 239 RR+LOV 1375 648 Sulfurovum sp. (strain NBC37-1) P(ε) A6Q686 YP_001357352.1 169 Short‐LOV 1376 649 Acidobacterium sp. (strain MP5ACTX9) Acido E8X1X9 YP_004217920.1 507 LOV+Kinase 1377 650 Terriglobus roseus strain DSM 18391 Acido I3ZG30 YP_006421533.1 525 PAS+LOV+GGDEF 1378 I3ZDW9 YP_006420772.1 522 LOV+Kinase 1379 I3ZJG2 YP_006422715.1 862 2PAS+LOV+GGDEF+EAL 1380 651 Turneriella parva ATCC BAA-1111 Spi I4BB34 YP_006441997.1 876 RR+2PAS+LOV+PAS+Kinase 1381 652 bacterium enrichment culture clone pWThLOV Unc B5M445 ACH61904.1 1204 GAF+2PAS+LOV+2PAS+Kinase+RR 1382 653 uncultured bacterium Unc K2EZH7 EKE24251.1 859 GAF+PAS+LOV+GGDEF+EAL 1383 K2FIR8 EKE10710.1 620 LOV+Kinase+RR 1384 654 Bacteriovorax sp. Seq25_V P(δ) T0RBD1 EQC43725.1 193 Short‐LOV 1385 655 Desulfococcus multivorans DSM 2059 P(δ) S7VBV4 WP_020875425.1 1264 LOV+GAF+PAS+Kinase+RR 1386 656 Myxococcus fulvus (strain ATCC BAA-855 / HW-1) P(δ) F8C6F8 YP_004665424.1 802 MASE1+LOV+Kinase+RR 1387 657 Myxococcus sp. (contaminant ex DSM 436) P(δ) WP_002637984.1 809 MASE1+LOV+Kinase+RR 1388 658 Myxococcus xanthus P(δ) Q84FB2 AAO22901.1 830 MASE1+LOV+Kinase+RR 1389 Myxococcus xanthus (strain DK 1622) P(δ) Q1CXA1 YP_634972.1 842 MASE1+LOV+Kinase+RR 1390

Archaeal LOV domains

Nr. Species/strain Group Accession nr. Uniprot Accession nr. NCBI aa nr. Domains Prot. nr 1 Haladaptatus paucihalophilus DX253 Eu A E7QV78 WP_007980661.1 621 PAS+LOV+GAF+HTH 1 2 Halalkalicoccus jeotgali DSM 18796 Eu A D8J3G3 YP_003737062.1 531 PAS+LOV+GAF+HTH 2 G0HVV3 YP_004795441.1 726 RR+PAS+LOV+PAS+Kinase 3 3 Halarchaeum acidiphilum EuA WP_021780048.1 548 ?-LOV 4 4 Haloarcula amylolytica JCM 13557 EuA M0KRQ6 WP_008309224.1 748 RR+LOV+GAF+Kinase 5 M0KMX5 WP_008310353.1 727 RR+PAS+LOV+Kinase 6 5 Haloarcula argentinensis DSM 12282 EuA M0KWF6 WP_005534440.1 748 RR+LOV+GAF+Kinase 7 M0KU22 WP_005535584.1 726 RR+PAS+LOV+Kinase 8 6 Haloarcula californiae ATCC 33799 EuA M0KKE6 WP_007188243.1 726 RR+PAS+LOV+Kinase 9 M0JSQ9 WP_007190397.1 748 RR+LOV+GAF+Kinase 10 7 Haloarcula hispanica ATCC 33960 EuA G0HRB1 YP_004796084.1 748 RR+PAS+LOV+GAF+Kinase 11 8 Haloarcula japonica DSM 6131 EuA M0L9V9 WP_004592775.1 748 RR+LOV+GAF+Kinase 12 M0LBV1 WP_004593543.1 726 RR+PAS+LOV+Kinase 13 M0LAY8 WP_004594204.1 599 RR+LOV+Kinase 14

A30

9 Haloarcula marismortui ATCC43049 EuA Q5UWI7 YP_138072.1 2306 PAS+GAF+4PAS+GAF+4PAS+LOV+3PAS+Kinase 15 Q5V5P7 YP_134861.1 726 RR+PAS+LOV+PAS+Kinase 16 Q5V3S3 YP_135535.1 748 RR+PAS+LOV+GAF+Kinase 17

10 Haloarcula sinaiiensis ATCC 33800 EuA M0K0A6 WP_004961457.1 748 RR+LOV+GAF+Kinase 18 M0JUG2 WP_004963306.1 726 RR+PAS+LOV+Kinase 19 M0JKN0 WP_004966422.1 870 RR+PAS+LOV+3PAS 20

11 Haloarcula vallismortis ATCC 29715 EuA M0IYI4 WP_004517958.1 748 RR+PAS+LOV+GAF+Kinase 21 M0JF54 WP_004516790.1 726 RR+PAS+LOV+Kinase 22

12 Halobiforma lacisalsi AJ5 EuA WP_007141411.1 1462 GAF+LOV+3PAS+2GAF+HTH 23 WP_007142266.1 628 PAS+LOV+HTH 24

13 Halobiforma nitratireducens JCM 10879 EuA M0LF83 WP_006674107.1 633 PAS+LOV+HTH 25 14 Haloferax alexandrinus JCM 10717 EuA M0I5C6 WP_006600750.1 658 LOV+GAF+HTH 26 M0I6S2 WP_006600643.1 858 LOV+4PAS+Kinase 27 WP_004062881.1 725 RR+PAS+LOV+PAS+Kinase 28

15 Haloferax denitrificans ATCC 35960 EuA M0JKW4 WP_004967303.1 639 RR+LOV+PAS+Kinase 29 M0JGT6 WP_004967308.1 390 RR+LOV 30 M0JA63 WP_004969028.1 659 LOV+GAF+HTH 31 M0J0Q3 WP_004970246.1 858 LOV+3PAS+Kinase 32

16 Haloferax elongans ATCC BAA-1513 EuA M0HS61 WP_008322780.1 661 LOV+GAF+HTH 33 17 Haloferax gibbonsii ATCC 33959 EuA M0H5U8 WP_004975760.1 716 RR+PAS+LOV+PAS+Kinase 34 M0H5P9 WP_004975752.1 369 RR+LOV 35 M0HJ57 WP_004973634.1 658 LOV+GAF+HTH 36 M0HIK5 WP_004972991.1 870 RR+LOV+3PAS+Kinase 37

18 Haloferax larsenii JCM 13917 EuA M0GTD6 WP_007544473.1 661 LOV+GAF+HTH 38 19 Haloferax lucentense DSM 14919 EuA M0GV43 ELZ87863.1/WP_004062881.1 725 RR+PAS+LOV+PAS+Kinase 39 M0GGW3 WP_004065380.1 658 LOV+GAF+HTH 40 M0GFK0 WP_004065100.1 858 LOV+3PAS+Kinase 41

20 *Haloferax mediterranei ATCC 33500 EuA I3R1D3 YP_006348030.1 667 LOV+GAF+HTH 42 21 Haloferax mucosum ATCC BAA-1512 EuA M0IDW1 WP_008319778.1 659 LOV+GAF+HTH 43 22 Haloferax prahovense DSM 18310 EuA M0G333 WP_008095971.1 712 RR+PAS+LOV+PAS+Kinase 44 M0GT38 WP_008091440.1 658 LOV+GAF+HTH 45 M0GL79 WP_008091948.1 871 LOV+3PAS+Kinase 46

23 Haloferax sp. ATCC BAA-644 EuA WP_008576999.1 658 LOV+GAF+HTH 47 WP_008577397.1 858 LOV+3PAS+Kinase 48 Haloferax sp. ATCC BAA-645 EuA M0G7U5 WP_008577920.1 731 RR+PAS+LOV+PAS+Kinase 49 WP_008577397.1 858 LOV+3PAS+Kinase 50 ELZ63079.1/WP_008576999.1 658 LOV+GAF+HTH 51 Haloferax sp. ATCC BAA-646 EuA M0FM96 WP_008579033.1 817 RR+PAS+LOV+PAS+Kinase 52 WP_008577397.1 858 LOV+3PAS+Kinase 53 M0FI62 ELZ58294.1/WP_008576999.1 658 LOV+GAF+HTH 54 Haloferax sp. BAB2207 EuA L5NY38 WP_008605787.1 646 RR+PAS+LOV+PAS+Kinase 55 L5NW28 WP_008606020.1 709 LOV+3PAS+Kinase 56 L5NIY0 WP_008609214.1 575 LOV+GAF+HTH 57

24 Haloferax sulfurifontis ATCC BAA-897 EuA M0I143 WP_007276041.1 640 RR+LOV+PAS+Kinase 58 M0HZH1 WP_007276043.1 369 RR+PAS+LOV 59 M0IBQ3 WP_007275007.1 606 LOV+GAF+HTH 60 M0HZS1 WP_007275764.1 858 LOV+PAS+Kinase 61

25 Haloferax volcanii DSM 3757 Eu A D4GU42 YP_003536054.1 652 RR+PAS+LOV+Kinase 62 D4GSN6 YP_003534694.1 858 LOV+3PAS+Kinase 63 D4GZU7 YP_003534395.1 658 LOV+GAF+HTH 64

26 Halonotius EuA WP_021039170.1 828 2PAS+LOV+2PAS+Kinase 65 27 Halonotius sp. J07HN4 EuA WP_021040232.1 763 PAS+LOV+PAS+Kinase 66

A31

WP_021040161.1 1018 2PAS+LOV+GAF+2PAS+Kinase 67 WP_021039668.1 966 RR+PAS+LOV+2PAS+Kinase 68

28 Halonotius sp. J07HN6 EuA WP_021062171.1 335 RR+LOV (truncated LOV domain) 69 WP_021061359.1 419 PAS+LOV 70 WP_021061848.1 697 PAS+LOV+PAS+Kinase 71

29 Halophilic archaeon DL31 EuA G2MKJ0 YP_004807311.1 400 LOV+Kinase 72 30 Halophilic archaeon J07HX64 EuA WP_021044206.1 666 RR+LOV+HTH 73 31 Halopiger xanaduensis DSM 18323 Eu A F8D4L2 YP_004596219.1 658 PAS+LOV+GAF+HTH 74 32 Haloquadratum walsbyi EuA WP_021050808.1 851 RR+PAS+LOV+PAS+Kinase 75 33 Halorhabdus tiamatea SARL4B Eu A F7PMY2 YP_008375964.1 677 RR+LOV+GAF+HTH 76 34 Halorhabdus utahensis DSM 12940 EuA C7NQP5 YP_003129237.1 680 RR+LOV+GAF+HTH 77 35 Halorubrum aidingense JCM 13560 EuA M0PCX2 WP_008001395.1 596 RR+PAS+LOV+Kinase 78 M0PAC7 WP_008000810.1 522 RR+ LOV+Kinase 79 M0PJA7 WP_007998980.1 981 LOV+5PAS+Kinase 80

36 Halorubrum arcis JCM 13916 EuA M0PIL7 WP_007996097.1 596 RR+PAS+LOV+Kinase 81 M0PIN6 WP_007996657.1 501 RR+ LOV+Kinase 82

37 Halorubrum californiensis DSM 19288 EuA M0EGK2 WP_008441071.1 594 RR+PAS+LOV+Kinase 83 M0DYT3 WP_008445922.1 683 PAS+LOV+GAF+PAS+Kinase 84 WP_008443170.1 743 RR+PAS+LOV+Kinase 85 M0EG61 WP_008441781.1 507 RR+ LOV+Kinase 86

38 Halorubrum coriense DSM 10284 EuA M0E8M1 WP_006114486.1 594 RR+PAS+LOV+Kinase 87 M0EM75 WP_006112652.1 510 RR+ LOV+Kinase 88

39 Halorubrum distributum JCM 9100 EuA M0EQI8 WP_004597500.1 596 RR+PAS+LOV+Kinase 89 M0EQ99 WP_004596794.1 502 RR+ LOV+Kinase 90

40 Halorubrum hochstenium ATCC 700873 EuA M0F978 WP_008584939.1 594 RR+PAS+LOV+Kinase 91 M0F8B0 WP_008584017.1 486 LOV+Kinase 92

41 Halorubrum kocurii JCM 14978 EuA M0PAC1 WP_008847455.1 607 RR+PAS+LOV+Kinase 93 M0NND4 WP_008849553.1 720 RR+PAS+LOV+Kinase 94 M0NXJ3 WP_008848851.1 555 LOV+GAF+HTH 95 M0P7I5 WP_008848390.1 493 RR+LOV+Kinase 96

42 Halorubrum lacusprofundi ATCC 49239 EuA B9LXB3 YP_002567701.1 587 PAS+LOV+PAS+kinase 97 B9LPK0 YP_002566358.1 294 LOV+Kinase 98

43 Halorubrum lipolyticum DSM 21995 EuA M0NMJ4 WP_008007944.1 620 RR+PAS+LOV+Kinase 99 M0NJB8 WP_008008306.1 494 LOV+Kinase 100

44 Halorubrum litoreum JCM 13561 EuA M0NPX9 WP_008367060.1 596 RR+PAS+LOV+Kinase 101 M0NL05 WP_008367611.1 501 RR+LOV+Kinase 102

45 Halorubrum saccharovorum DSM 1137 EuA M0E2F0 WP_004047251.1 590 RR+PAS+LOV+Kinase 103 M0DW79 WP_004048308.1 717 RR+PAS+LOV+PAS+Kinase 104 M0E4X7 WP_004046404.1 475 RR+LOV+Kinase 105

46 Halorubrum sp. T3 EuA WP_017343793.1 596 RR+PAS+LOV+Kinase 106 WP_017344163.1 506 RR+LOV+Kinase 107

47 Halorubrum tebenquichense DSM 14210 EuA M0DVK1 WP_006628902.1 1102 RR+PAS+LOV 108 M0DE24 WP_006630444.1 461 LOV+Kinase 109

48 Halorubrum terrestre JCM 10247 EuA M0D8R1 WP_007345452.1 596 RR+PAS+LOV+Kinase 110 M0DD56 WP_007345203.1 501 RR+ LOV+Kinase 111

49 Halosimplex carlsbadense 2-9-1 EuA M0CWF6 WP_006882975.1 972 RR+PAS+LOV+3PAS+Kinase 112 M0D066 WP_006882606.1 652 RR+LOV+GAF+HTH 113 M0D0B9 WP_006882998.1 648 GAF+PAS+LOV+Kinase 114 WP_006882499.1 1794 LOV+8PAS+GAF+HTH 115

50 Haloterrigena limicola JCM 13563 EuA M0CPI1 WP_008009308.1 633 PAS+LOV+GAF+HTH 116 51 Haloterrigena salina JCM 13891 EuA M0BXZ7 WP_008896043.1 643 PAS+LOV+GAF+HTH 117 M0C8L1 WP_008893875.1 652 GAF+PAS+LOV+Kinase 118

A32

52 Haloterrigena thermotolerans DSM 11522 EuA M0BP65 WP_006650177.1 627 PAS+LOV+GAF+HTH 119 53 Haloterrigena turkmenica DSM 5511 Eu A D2RWH0 YP_003402232.1 644 PAS+LOV+GAF+HTH 120 D2RZP8 YP_003404760.1 654 GAF+PAS+LOV+Kinase 121

54 Halovivax asiaticus JCM 14624 Eu A M0BRR0 WP_007697375.1 674 RR+LOV+GAF+HTH 122 55 Halovivax ruber XH-70 EuA L0IC85 YP_007283949.1 674 LOV+GAF+HTH 123 56 Methanoculleus bourgensis ATCC 43281 EuA YP_006543787.1 630 2PAS+GAF+LOV+Kinase 124 YP_006545702.1 971 4PAS+LOV+Kinase 125

57 Methanoculleus marisnigri ATCC 35101 EuA YP_001047260.1 888 4PAS+LOV+Kinase 126 YP_001046186.1 630 2PAS+GAF+LOV+Kinase 127 A3CUN9 YP_001047071.1 753 2PAS+LOV+Kinase 128

58 Methanolobus psychrophilus R15 EuA YP_006922864.1 541 LOV+Kinase+RR 129 59 Methanoplanus limicola DSM 2279 EuA H1YYA6 WP_004075781.1 476 PAS+LOV+PAS+Kinase 130 60 Methanosphaerula palustris ATCC BAA-1556 EuA YP_002465170.1 968 PAS+LOV+3PAS+Kinase 131 61 Natrialba chahannaoensis JCM 10990 EuA M0B9X5 WP_006165579.1 478 RR+LOV+Kinase 132 62 Natrialba hulunbeirensis JCM 10989 EuA L9ZYC6 WP_006653494.1 478 RR+LOV+Kinase 133 M0AA97 WP_006651477.1 736 RR+2PAS+LOV+Kinase 134

63 Natrialba magadii ATCC 43099 Eu A D3SVK4 YP_003480174.1 477 RR+LOV+Kinase 135 64 Natrinema altunense JCM 12890 Eu A L9ZYN2 WP_007107921.1 629 PAS+LOV+HTH 136 65 Natrinema gari JCM 14663 Eu A L9YWZ4 WP_008457298.1 630 PAS+LOV+HTH 137 66 Natrinema pallidum DSM 3751 Eu A L9YJK9 WP_006187119.1 649 PAS+LOV+HTH 138 67 Natrinema pellirubrum DSM 15624 Eu A L9YNP9 WP_006181371.1 657 LOV+GAF+HTH 139 L0JQR8 YP_007281871.1 627 PAS+LOV+GAF+HTH 140

68 *Natrinema sp. (strain J7-2) EuA I7C1F5 YP_006543291.1 630 PAS+LOV+HTH 141 69 Natrinema versiforme JCM 10478 EuA L9XNH7 WP_006432901.1 717 RR+PAS+LOV+PAS+Kinase 142 L9YBA9 WP_006429256.1 631 PAS+LOV+HTH 143

70 Natronobacterium gregoryi SP2 EuA L0AGT8 YP_007176754.1 616 PAS+LOV+GAF+HTH 144 L0AIG8 YP_007177421.1 1517 GAF+LOV+4PAS+2GAF+HTH 145

71 Natronococcus amylolyticus DSM 10524 EuA L9XFR4 WP_005554108.1 618 PAS+LOV+HTH 146 Natronococcus amylolyticus DSM 10524 EuA WP_005554006.1 634 LOV+PAS+GAF+Kinase 147

72 Natronococcus jeotgali DSM 18795 EuA L9WMX9 WP_008427349.1 619 PAS+LOV+HTH 148 73 Natronococcus occultus SP4 EuA L0JXN1 YP_007308413.1 634 LOV+PAS+GAF+Kinase 149 L0JTP7 YP_007308142.1 616 PAS+LOV+HTH 150

74 Natronolimnobius innermongolicus JCM 12255 EuA L9XAN4 WP_007258756.1 655 RR+PAS+LOV+PAS+Kinase 151 L9XE91 WP_007258481.1 645 PAS+LOV+GAF+HTH 152

75 Natronomonas moolapensis 8.8.11 EuA YP_007486593.1 583 LOV+PAS+Kinase 153 YP_007486271.1 673 RR+LOV+GAF+HTH 154 YP_007487143.1 723 LOV+Kinase 155 YP_007488415.1 652 RR+LOV+GAF+PAS 156 YP_007487711.1 583 PAS+LOV+PAS+Kinase 157

76 Natronomonas pharaonis DSM 2160 EuA Q3ITW5 YP_325987.1 681 RR+LOV+GAF+HTH 158 Q3IM51 YP_327664.1 596 PAS+LOV+PAS+Kinase 159

77 Natronorubrum bangense JCM 10635 EuA L9WG87 WP_006066370.1 646 PAS+LOV+HTH 160 WP_006067023.1 480 LOV+PAS+Kinase 161

78 Natronorubrum sulfidifaciens JCM 14089 EuA L9W7D2 WP_008162495.1 638 PAS+LOV+HTH 162 79 Natronorubrum tibetense EuA WP_006090010.1 1005 PAS+LOV+3PAS+Kinase 163 80 Natronorubrum tibetense GA33 EuA L9W0I4 WP_006088978.1 646 PAS+LOV+HTH 164 L9VKX1 WP_006092104.1 563 PAS+LOV+PAS+Kinase 165

81 Salinarchaeum sp. Harcht-Bsk1 EuA YP_008054154.1 874 RR+PAS+LOV+2PAS+Kinase 166 82 Halogeometricum borinquenseATCC 700274 EuA E4NMD1 YP_004036781.1 648 GAF+PAS+LOV+Kinase 167 1

A33

Bacterial BLUF domains

Nr. Species/strain Group Accession nr. Uniprot Accession nr. NCBI aa nr. Domains 1 Enterococcus gallinarum EGD-AAK12 F ERE59647.1 405 BLUF+EAL 1 2 Actinomycetospora chiangmaiensis Ac WP_018332181.1 148 Short-BLUF 2

WP_018331556.1 175 Short-BLUF 3 WP_018332897.1 150 Short-BLUF 4 WP_018331430.1 141 Short-BLUF 5

3 Actinoplanes sp. N902-109 Ac R4LLI6 YP_007952341.1 135 Short-BLUF 6 4 Clavibacter michiganensis subsp. michiganensis NCPPB 382 Ac A5CNT4 YP_001221435.1 142 Short-BLUF 7

A5CM94 YP_001220898.1 148 Short-BLUF 8 5 Clavibacter michiganensis subsp. nebraskensis NCPPB 2581 Ac M5B6Z4 YP_007684954.1 142 Short-BLUF 9

M5B789 YP_007684430.1 139 Short-BLUF 10 6 Clavibacter michiganensis subsp. sepedonicus ATCC 33113 Ac B0RBP8 126 Short-BLUF 11

B0RFL5 YP_001710824.1 142 Short-BLUF 12 7 Corynebacterium efficiens DSM 44549 Ac Q8FMY2 NP_738977.1 158 Short-BLUF 13 8 Corynebacterium maris DSM 45190 Ac S5TI47 YP_008371038.1 159 Short-BLUF 14 9 Curtobacterium flaccumfaciens Ac WP_017888306.1 142 Short-BLUF 15

WP_017888712.1 190 Short-BLUF 16 10 Curtobacterium sp. B18 Ac WP_022907696.1 142 Short-BLUF 17

WP_022907690.1 156 Short-BLUF 18 Curtobacterium sp. B8 Ac WP_022902403.1 109 Short-BLUF 19 WP_022904642.1 168 Short-BLUF 20 WP_022902388.1 149 Short-BLUF 21 WP_022902223.1 139 Short-BLUF 22 11 Dietzia alimentaria Ac WP_010540020.1 158 Short-BLUF 23 12 Dietzia sp. UCD-THP Ac WP_017837588.1 160 Short-BLUF 24

WP_017836468.1 158 Short-BLUF 25 13 Ilumatobacter coccineus YM16-304 Ac M4ZW07 YP_007562816.1 353 BLUF+GGDEF 26 14 Leifsonia xyli subsp. cynodontis DSM 46306 Ac YP_008579210.1 168 Short-BLUF 27 15 Leifsonia xyli subsp. xyli Ac Q6AGS2 YP_061528.1 145 Short-BLUF 28 16 Leucobacter chromiiresistens Ac WP_010155083.1 154 Short-BLUF 29 17 Microbacterium maritypicum MF109 Ac T5KEX1 WP_021201284.1 162 Short-BLUF 30 18 Microbacterium paraoxydans Ac WP_018186897.1 149 Short-BLUF 31

WP_018187668.1 142 Short-BLUF 32 19 Microbacterium sp. 11MF Ac WP_020098083.1 149 Short-BLUF 33

WP_020098408.1 142 Short-BLUF 34 Microbacterium sp. B19 Ac WP_022879455.1 146 Short-BLUF 35 Microbacterium sp. TS-1 Ac GAD34866.1 156 Short-BLUF 36 Microbacterium sp. UCD-TDU Ac WP_017829376.1 174 Short-BLUF 37 WP_017829365.1 193 Short-BLUF 38 20 Microbacterium testaceum (strain StLB037) Ac E8NB71 YP_004224598.1 145 Short-BLUF 39 21 Afipia sp. 1NLS2 P(α) D6V881 WP_009340159.1 151 Short-BLUF 40 22 Ahrensia sp. R2A130 P(α) E0MSP0 WP_009758676.1 125 Short-BLUF 41 23 alpha proteobacterium BAL199 P(α)U A8TQR5 WP_007672921.1 124 Short-BLUF 42 24 alpha proteobacterium JLT2015 P(α)U M2T6L9 WP_008603323.1 133 Short-BLUF 43 25 alpha proteobacterium L41A P(α)U WP_017506466.1 135 Short-BLUF 44 26 alpha proteobacterium SCGC AAA076-C03 P(α)U WP_020057179.1 142 Short-BLUF 45

A34

27 alpha proteobacterium SCGC AAA298-K06 P(α)U WP_020044700.1 140 Short-BLUF 46 28 Amorphus coralli P(α) WP_018701439.1 148 Short-BLUF 47 29 Asticcacaulis benevestitus P(α) WP_018084049.1 161 Short-BLUF 48

WP_023447472.1 163 Short-BLUF 49 30 Asticcacaulis biprosthecum C19 P(α) F4QHK8 WP_006271926.1 122 Short-BLUF 50 31 Asticcacaulis sp. AC460 P(α) WP_023451483.1 140 Short-BLUF 51

Asticcacaulis sp. AC466 P(α) WP_023459633.1 139 Short-BLUF 52 WP_023456967.1 169 Short-BLUF 53 Asticcacaulis sp. YBE204 P(α) WP_023462718.1 148 Short-BLUF 54 32 Aureimonas ureilytica P(α) WP_019995874.1 108 Short-BLUF 55

WP_019998548.1 138 Short-BLUF 56 33 Azospirillum lipoferum (strain 4B) P(α) G7ZDG1 YP_004974645.1 163 Short-BLUF 57

G7Z5P1 YP_005039978.1 161 Short-BLUF 58 34 Blastomonas sp. AAP53 P(α) WP_017672203.1 135 Short-BLUF 59 35 Bradyrhizobium sp. STM 3809 P(α) H0SXV9 WP_008961634.1 151 Short-BLUF 60

H0T8Q2 WP_008965377.1 125 Short-BLUF 61 36 Brevundimonas abyssalis TAR-001 P(α) U2ZDP3 WP_021697307.1 100 Short-BLUF 62 37 Brevundimonas diminuta 470-4 P(α) L1QEI8 WP_003168376.1 133 Short-BLUF 63

L1QGZ1 WP_003168022.1 165 Short-BLUF 64 38 Brevundimonas diminuta ATCC 11568 P(α) F4QZ49 WP_003166443.1 136 Short-BLUF 65

F4R104 WP_003166654.1 136 Short-BLUF 66 39 Brevundimonas sp. BAL3 P(α) B4W666 WP_008261602.1 136 Short-BLUF 67

B4WEH9 WP_008264082.1 151 Short-BLUF 68 B4W667 WP_008262982.1 141 Short-BLUF 69 40 Brevundimonas subvibrioides ATCC 15264 P(α) D9QFJ9 YP_003820137.1 133 Short-BLUF 70

D9QF25 YP_003818133.1 148 Short-BLUF 71 D9QJR6 YP_003817291.1 137 Short-BLUF 72 D9QHQ8 YP_003816957.1 129 Short-BLUF 73 D9QN89 YP_003817913.1 167 Short-BLUF 74 41 Caenispirillum salinarum AK4 P(α) K9GNQ3 WP_009542082.1 148 Short-BLUF 75 42 Caulobacter sp. JGI 0001010-J14 P(α) WP_019847616.1 155 Short-BLUF 76

Caulobacter sp. JGI 0001013-D04 P(α) WP_018113275.1 155 Short-BLUF 77 43 Citreicella sp. 357 P(α) I1ASF9 WP_009506357.1 135 Short-BLUF 78

Citreicella sp. SE45 P(α) D0D5D9 WP_008885899.1 131 Short-BLUF 79 44 Dinoroseobacter shibae DFL 12 P(α) A8LL23 YP_001534373.1 135 Short-BLUF 80 45 Fodinicurvata sediminis P(α) WP_022728487.1 145 Short-BLUF 81 46 Fulvimarina pelagi HTCC2506 P(α) Q0G5H1 WP_007067067.1 144 Short-BLUF 82

Q0G0Q7 WP_007068840.1 145 Short-BLUF 83 Q0G114 WP_007068733.1 122 Short-BLUF 84 47 Henriciella marina P(α) WP_018146618.1 137 Short-BLUF 85

WP_018146679.1 136 Short-BLUF 86 WP_018147000.1 146 Short-BLUF 87 48 Hoeflea phototrophica DFL-43 P(α) A9DDP2 WP_007196455.1 130 Short-BLUF 88 49 Hyphomonas neptunium ATCC 15444 P(α) Q0C3J3 YP_759700.1 152 Short-BLUF 89 50 Jannaschia sp. (strain CCS1) P(α) Q28NL5 YP_510722.1 164 Short-BLUF 90

Q28QR5 YP_509972.1 150 Short-BLUF 91 Q28M24 YP_511263.1 135 Short-BLUF 92 51 Labrenzia aggregata IAM 12614 P(α) A0NTY6 WP_006935087.1 152 Short-BLUF 93 52 Labrenzia alexandrii DFL-11 P(α) B9QVG5 WP_008192786.1 152 Short-BLUF 94

A35

53 Loktanella vestfoldensis P(α) WP_019955376.1 138 Short-BLUF 95 Loktanella vestfoldensis SKA53 P(α) A3V3H6 WP_007204263.1 136 Short-BLUF 96 54 Magnetospirillum gryphiswaldense P(α) A4U007 CAM76214.1 156 Short-BLUF 97

A4U445 CAM77652.1 151 Short-BLUF 98 55 Maricaulis maris (strain MCS10) P(α) Q0AMF1 YP_757480.1 152 Short-BLUF 99

Q0ALH8 YP_757803.1/NP_949618.1 141 Short-BLUF 100 56 Maricaulis sp. JL2009 P(α) WP_022699434.1 141 Short-BLUF 101 57 Methylobacterium chloromethanicum CM4 P(α) B7KRN3 YP_002423488.1/YP_002422117.1 150 Short-BLUF 102

B7KN60 YP_002423105.1 148 Short-BLUF 103 B7L1R5 YP_002419387.1 150 Short-BLUF 104 C5B322 YP_002965329.1 148 Short-BLUF 105 58 Methylobacterium extorquens AM1 P(α) C5AVI4 YP_002961929.1/YP_001638425.1 155 Short-BLUF 106

C7CE09 YP_003066731.1/YP_001638425.1 155 Short-BLUF 107 Methylobacterium extorquens DM4 P(α) C7CJD7 YP_003070453.1 148 Short-BLUF 108 H1KED3 WP_003597563.1/YP_002965329.1 148 Short-BLUF 109 Methylobacterium extorquens DSM 13060 P(α) H1KPI6 WP_003603713.1/YP_001638425.1 155 Short-BLUF 110 A9VWG7 YP_001637613.1 150 Short-BLUF 111 Methylobacterium extorquens PA1 P(α) A9W8Q2 YP_001641472.1 148 Short-BLUF 112 A9W198 YP_001638425.1 155 Short-BLUF 113 59 Methylobacterium mesophilicum SR1.6/6 P(α) M7XWX4 WP_010687537.1 294 BLUF 114

M7XZR2 WP_010683805.1 155 Short-BLUF 115 60 Methylobacterium nodulans ORS 2060 P(α) B8IB70 YP_002497588.1 155 Short-BLUF 116 61 Methylobacterium populi ATCC BAA-705 P(α) B1ZGT3 YP_001927146.1 162 Short-BLUF 117

B1Z908 YP_001923601.1 155 Short-BLUF 118 62 Methylobacterium radiotolerans ATCC 27329 P(α) B1M482 YP_001757060.1 309 Short-BLUF 119

B1M108 YP_001755241.1 139 Short-BLUF 120 B1LTA6 YP_001753095.1 143 Short-BLUF 121 B1M0G5 YP_001758170.1 155 Short-BLUF 122 63 Methylobacterium sp. 285MFTsu5.1 P(α) WP_020092935.1 155 Short-BLUF 123

Methylobacterium sp. 4-46 P(α) B0UJP3 YP_001769419.1 150 Short-BLUF 124 B0ULI8 YP_001770966.1 155 Short-BLUF 125 B0U8I2 YP_001768746.1 296 Short-BLUF 126 B0UQT1 YP_001771351.1 162 Short-BLUF 127 B0UIK0 YP_001770814.1 373 Short-BLUF 128 Methylobacterium sp. 77 P(α) WP_019905219.1 155 Short-BLUF 129 Methylobacterium sp. 88A P(α) WP_018045976.1 150 Short-BLUF 130 WP_018044868.1 155 Short-BLUF 131 Methylobacterium sp. GXF4 P(α) I9CMR0 WP_007562637.1 306 Short-BLUF 132 I9LE30 WP_007566415.1 155 Short-BLUF 133 Methylobacterium sp. MB200 P(α) WP_017484131.1 156 Short-BLUF 134 WP_017487136.1 155 Short-BLUF 135 Methylobacterium sp. WSM2598 P(α) WP_018261940.1 290 Short-BLUF 136 64 Methylocystis rosea P(α) WP_018408523.1 134 Short-BLUF 137 65 Methylocystis sp. (strain SC2) P(α) J7QPQ2 YP_006590526.1 134 Short-BLUF 138 66 Oceanicaulis alexandrii P(α) WP_022700825.1 149 Short-BLUF 139 67 Oceaniovalibus guishaninsula JLT2003 P(α) K2HTA6 WP_007425238.1 138 Short-BLUF 140 68 Octadecabacter antarcticus 307 P(α) M9RHP8 YP_007706545.1 143 Short-BLUF 141

M9R7E3 YP_007705193.1 170 Short-BLUF 142 M9RA14 YP_007705656.1 170 Short-BLUF 143

A36

M9RGN7 YP_007705589.1 158 Short-BLUF 144 69 Octadecabacter arcticus 238 P(α) M9RPU8 YP_007699880.1 146 Short-BLUF 145 70 Pannonibacter phragmitetus P(α) WP_019963279.1 150 Short-BLUF 146

WP_019963280.1 152 Short-BLUF 147 71 Paracoccus sp. N5 P(α) WP_017999944.1 138 Short-BLUF 148 72 Paracoccus zeaxanthinifaciens P(α) WP_022708278.1 141 Short-BLUF 149 73 Parvibaculum lavamentivorans DS-1 P(α) A7HQ46 YP_001411686.1/WP_011995320.1 153 Short-BLUF 150 74 Phaeospirillum molischianum DSM 120 P(α) H8FX83 WP_002730899.1 150 Short-BLUF 151 75 Phenylobacterium zucineum HLK1 P(α) B4RAQ0 YP_002132077.1 166 Short-BLUF 152 76 Polymorphum gilvum LMG 25793 P(α)poly F2J5Y4 YP_004304542.1 156 Short-BLUF 153 77 Porphyrobacter sp. AAP82 P(α) WP_017663773.1 152 Short-BLUF 154

WP_017663774.1 130 Short-BLUF 155 78 Pseudovibrio sp. JE062 P(α) B6R848 WP_008551887.1 152 Short-BLUF 156 79 Puniceispirillum marinum (strain IMCC1322) P(α) D5BS69 YP_003551200.1 411 RRF-BLUF 157 80 Rhodobacter sp. AKP1 P(α) L1KCR3 WP_009563298.1 140 Short-BLUF 158

L1K965 WP_009564586.1 450 BLUF+SCHICH 159 81 Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) P(α) Q53119 YP_351608.1 450 BLUF+SCHICH 160

Rhodobacter sphaeroides ATCC 17023/2.4.1 P(α) Q3J677 YP_351608.1 450 BLUF+SCHICH¶ 161 Q3IV98 YP_345277.1 134 Short-BLUF 162 Q3IYE4 YP_354341.1/WP_011338827.1 140 Short-BLUF 163 Rhodobacter sphaeroides ATCC 17025 P(α) A4WX15 YP_001169234.1 448 BLUF+SCHICH 164 A4WZZ2 YP_001170261.1 135 Short-BLUF 165 Rhodobacter sphaeroides ATCC 17029 P(α) A3PG69 YP_001042107.1 450 BLUF+SCHICH 166 A3PNV7 YP_001044795.1 140 Short-BLUF 167 Rhodobacter sphaeroides KD131 P(α) B9KRZ4 YP_002527323.1 450 BLUF+SCHICH 168 B9KPY5 YP_002527021.1 128 Short-BLUF 169 Rhodobacter sphaeroides WS8N P(α) F3U4S4 WP_002724946.1 174 BLUF+TETR 170 F5M0G5 EGJ22762.1/YPP_001044795.1 140 Short-BLUF 171 F5M357 WP_002722303.1 450 BLUF+SCHICH 172 82 Rhodobacterales bacterium HTCC2255 P(α) Q0FFK4 WP_008034321.1 142 Short-BLUF 173

Rhodobacterales bacterium Y4I P(α) B6BAZ4 WP_008557343.1 145 Short-BLUF 174 83 Rhodopseudomonas palustris (strain HaA2) P(α) Q2J2T2 YP_484139.1 141 Short-BLUF 175

Rhodopseudomonas palustris BisA53 P(α) Q07KQ3 YP_782461.1 202 Short-BLUF 176 Q07NU1 YP_781373.1 172 Short-BLUF 177 Q07V95 YP_779119.1 146 Short-BLUF 178 Q07LL8 YP_782146.1 134 Short-BLUF 179 Rhodopseudomonas palustris BisB18 P(α) Q211J0 YP_533265.1 225 Short-BLUF 180 Q21C17 YP_530388.1 147 Short-BLUF 181 Q214S4 YP_532431.1 131 Short-BLUF 182 Rhodopseudomonas palustris CGA009 P(α) Q6NCF0 NP_945875.1 147 Short-BLUF 183 Q6N1X0 NP_949618.1 157 Short-BLUF 184 Q6N4H0 NP_948706.1 156 Short-BLUF 185 Rhodopseudomonas palustris DX-1 P(α) E6VP72 YP_004108354.1 148 Short-BLUF 186 E6VKR4 YP_004106926.1 147 Short-BLUF 187 E6VPR9 YP_004110781.1 157 Short-BLUF 188 Rhodopseudomonas palustris TIE-1 P(α) B3QE01 YP_001992821.1 148 Short-BLUF 189 B3QBC9 YP_001989558.1 147 Short-BLUF 190 B3Q6V3 YP_001993727.1 157 Short-BLUF 191 84 Rhodopseudomonas sp. B29 P(α) WP_022723876.1 156 Short-BLUF 192

A37

85 Rhodospirillum centenum ATCC 51521 / SW P(α) B6IP78 YP_002298393.1 148 Short-BLUF 193 86 Rhodospirillum photometricum DSM 122 P(α) H6SMN4 YP_005418139.1 175 Short-BLUF 194 87 Rhodovulum sp. PH10 P(α) J6UCI9 WP_008388881.1 164 Short-BLUF 195

J6UFI8 WP_008385672.1 144 Short-BLUF 196 88 Robiginitomaculum antarcticum P(α) WP_017931728.1 138 Short-BLUF 197 89 Roseibium sp. TrichSKD4 P(α) E2CEP5 WP_009466697.1 157 Short-BLUF 198 90 Roseobacter denitrificans OCh 114 P(α) Q169R5 YP_681964.1 131 Short-BLUF 199 91 Roseobacter litoralis OCh 149 P(α) F7ZIV2 YP_004691975.1 131 Short-BLUF 200 92 Roseobacter sp. AzwK-3b P(α) A6FLZ7 WP_007812297.1 138 Short-BLUF 201

Roseobacter sp. CCS2 P(α) A4EDL7 WP_008230522.1 158 Short-BLUF 202 A4EKD4 WP_008234592.1 95 Short-BLUF 203 Roseobacter sp. GAI101 P(α) B7RMG6 WP_008228573.1 108 Short-BLUF 204 Roseobacter sp. MED193 P(α) A3X3E5 WP_009811077.1 146 Short-BLUF 205 Roseobacter sp. SK209-2-6 P(α) A4EP54 WP_008203735.1 143 Short-BLUF 206 93 Roseovarius sp. 217 P(α) A3W442 WP_009816911.1 137 Short-BLUF 207

Roseovarius sp. HTCC2601 P(α) Q0FHM9 WP_007792538.1 131 Short-BLUF 208 Roseovarius sp. TM1035 P(α) A6E0Y7 WP_008281285.1 137 Short-BLUF 209 94 Rubellimicrobium thermophilum DSM 16684 P(α) S9QTZ7 WP_021097950.1 142 Short-BLUF 210 95 Sagittula stellata E-37 P(α) A3JXI1 WP_005854872.1 157 Short-BLUF 211

A3JYT3 WP_005855744.1 177 Short-BLUF 212 96 Silicibacter sp. TrichCH4B P(α) C9CW04 WP_009176168.1 144 Short-BLUF 213

C9CW06 WP_009176303.1 131 Short-BLUF 214 Silicibacter sp.TM1040 P(α) Q1GF07 YP_614021.1 144 Short-BLUF 215 Q1GF09 YP_614019.1 169 Short-BLUF 216 97 Sphingobium baderi LL03 P(α) T0GMM3 WP_021243582.1 138 Short-BLUF 217 98 Sphingobium chlorophenolicum L-1 P(α) F6ETZ8 YP_004552311.1 138 Short-BLUF 218 99 Sphingobium indicum B90A P(α) I5BF60 WP_007684659.1 138 Short-BLUF 219

100 Sphingobium japonicum BiD32 P(α) N1MG97 WP_006950198.1 129 Short-BLUF 220 Sphingobium japonicum NBRC 101211 / UT26S P(α) D4Z033 YP_003544577.1 138 Short-BLUF 221 101 Sphingobium lactosutens DS20 P(α) T0J2S2 WP_021225549.1 133 Short-BLUF 222 102 Sphingobium quisquiliarum P25 P(α) T0H8I1 WP_021237988.1 127 Short-BLUF 223 103 Sphingobium sp. HDIP04 P(α) T0G7F1 WP_020818413.1 138 Short-BLUF 224 Sphingobium sp. YL23 P(α) WP_022681831.1 139 Short-BLUF 225 WP_022683884.1 136 Short-BLUF 226 WP_022682837.1 133 Short-BLUF 227 104 Sphingobium ummariense RL-3 P(α) T0IST7 WP_021318238.1 137 Short-BLUF 228 105 Sphingobium xenophagum P(α) WP_019051433.1 129 Short-BLUF 229 WP_017182074.1 129 Short-BLUF 230 106 Sphingomonas P(α) WP_010164332.1 130 Short-BLUF 231 107 Sphingomonas elodea P(α) WP_010543334.1 131 Short-BLUF 232 108 Sphingomonas phyllosphaerae P(α) WP_022687793.1 153 Short-BLUF 233 109 Sphingomonas sp. Mn802worker P(α) WP_019517102.1 138 Short-BLUF 234 Sphingomonas sp. PAMC 26605 P(α) WP_010188000.1 131 Short-BLUF 235 WP_010187435.1 215 Short-BLUF 236 WP_010187036.1 135 Short-BLUF 237 WP_010186219.1 148 Short-BLUF 238 Sphingomonas sp. PAMC 26617 P(α) WP_010163859.1 146 Short-BLUF 239 WP_010164991.1 147 Short-BLUF 240 Sphingomonas sp. PAMC 26621 P(α) WP_010219263.1 240 Short-BLUF 241

A38

WP_010219976.1 148 Short-BLUF 242 WP_010217326.1 141 Short-BLUF 243 WP_010219296.1 134 Short-BLUF 244 WP_010217042.1 165 Short-BLUF 245 WP_010219603.1 133 Short-BLUF 246 WP_010219403.1 147 Short-BLUF 247 WP_010219691.1 140 Short-BLUF 248 WP_010220036.1 81 Short-BLUF 249 Sphingomonas sp. S17 P(α) F3X316 WP_007406954.1 130 Short-BLUF 250 Sphingomonas sp. SKA58 P(α) Q1NAZ4 WP_009821301.1 133 Short-BLUF 251 110 Sphingomonas wittichii P(α) WP_016746531.1 150 Short-BLUF 252 Sphingomonas wittichii RW1 P(α) A5VFD3 YP_001265137.1 164 Short-BLUF 253 111 Sphingomonas-like bacterium B12 P(α) WP_022691481.1 137 Short-BLUF 254 112 Sphingopyxis alaskensis P(α) Q1GWG4 YP_615341.1 141 Short-BLUF 255 113 Sphingopyxis baekryungensis P(α) WP_022672508.1 704 GGDEF+EAL+BLUF 256 WP_022673489.1 136 Short-BLUF 257 114 Sphingopyxis sp. MC1 P(α) N9WHS2 WP_003038631.1 138 Short-BLUF 258 115 Sulfitobacter guttiformis P(α) J7G2U7 YP_006965188.1 144 Short-BLUF 259 116 Sulfitobacter sp. EE-36 P(α) A3S970 WP_005850501.1 110 Short-BLUF 260 Sulfitobacter sp. NAS-14.1 P(α) A3SU32 WP_009825579.1 110 Short-BLUF 261 117 Variovorax paradoxus B4 P(α) T1X5J0 YP_008514845.1 134 Short-BLUF 262 118 Achromobacter xylosoxidans P(β) F7SWX0 WP_006391283.1 408 BLUF+EAL 263 Achromobacter xylosoxidans NH44784-1996 P(β) R4XQI4 YP_008030152.1 408 BLUF+EAL 264 119 Acidovorax avenae P(β) WP_019702121.1 140 Short-BLUF 265 Acidovorax avenae ATCC 19860 P(β) F0QCG3 YP_004236013.1 140 Short-BLUF 266 F0Q3D8 YP_004236407.1 137 Short-BLUF 267 120 Acidovorax avenae sub. citrulli AAC00-1 P(β) A1TT92 YP_971954.1 140 Short-BLUF 268 A1TUE4 YP_972356.1 137 Short-BLUF 269 121 Acidovorax delafieldii 2AN P(β) C5TAV7 WP_005799771.1 140 Short-BLUF 270 C5TBB6 WP_005799950.1 132 Short-BLUF 271 122 Acidovorax ebreus TPSY P(β) B9ME34 YP_002552288.1 140 Short-BLUF 272 123 Acidovorax radicis P(β) WP_010466631.1 132 Short-BLUF 273 WP_010461918.1 140 Short-BLUF 274 WP_010465348.1 139 Short-BLUF 275 124 Acidovorax sp. CF316 P(β) J0KJ25 WP_007856976.1 132 Short-BLUF 276 J1EI97 WP_007855842.1 140 Short-BLUF 277 J0U4I2 WP_007857182.1 139 Short-BLUF 278 Acidovorax sp. JS42 P(β) A1W4E7 YP_985198.1 140 Short-BLUF 279 Acidovorax sp. KKS102 P(β) K0IEC4 YP_006856384.1 132 Short-BLUF 280 YP_006853313.1 140 Short-BLUF 281 K0I309 YP_006854227.1 139 Short-BLUF 282 Acidovorax sp. MR-S7 P(β) WP_020229597.1 140 Short-BLUF 283 Acidovorax sp. NO-1 P(β) H0C3A0 WP_008906782.1 139 Short-BLUF 284 H0BYE8 WP_008905106.1 140 Short-BLUF 285 H0C4J7 WP_008907226.1 132 Short-BLUF 286 125 Alicycliphilus denitrificans DSM 14773 P(β) F4G8R2 YP_004386855.1 140 Short-BLUF 287 Alicycliphilus denitrificans JCM 14587 P(β) E8U0X9 YP_004125618.1 140 Short-BLUF 288 126 beta proteobacterium KB13 P(β)U B6BTG8 WP_009852483.1 135 Short-BLUF 289 127 beta proteobacterium L13 P(β) WP_017509222.1 142 Short-BLUF 290

A39

128 Betaproteobacteria bacterium MOLA814 P(β)Unc WP_023472146.1 141 Short-BLUF 291 129 Bordetella avium (strain 197N) P(β) Q2L1Z3 YP_786068.1 421 BLUF+EAL 292 130 Brachymonas chironomi P(β) WP_018715076.1 140 Short-BLUF 293 131 Burkholderia bryophila P(β) WP_020069946.1 171 Short-BLUF 294 132 Burkholderia sp. CCGE1003 P(β) E1TCW7 YP_003907473.1 174 Short-BLUF 295 133 Burkholderiales bacterium JOSHI_001 P(β) H5WUY1 WP_009548903.1 143 Short-BLUF 296 H5WRM6 WP_009552427.1 157 Short-BLUF 297 H5WLF9 WP_009549831.1 142 Short-BLUF 298 H5WT39 WP_009553481.1 137 Short-BLUF 299 134 Caldimonas manganoxidans P(β) WP_019560888.1 143 Short-BLUF 300 135 Chromobacterium violaceum P(β) Q7NSR1 NP_903029.1 141 Short-BLUF 301 136 Comamonadaceae bacterium CR P(β) YP_008681716.1 140 Short-BLUF 302 YP_008682224.1 144 Short-BLUF 303 137 Comamonas testosteroni (strain CNB-2) P(β) D0J3Z8 YP_003277487.1 135 Short-BLUF 304 D0J4M9 YP_003277583.1 131 Short-BLUF 305 Comamonas testosteroni ATCC 11996 P(β) H1RQ19 WP_003076132.1 132 Short-BLUF 306 Comamonas testosteroni S44 P(β) D8DEA6 WP_003071555.1 132 Short-BLUF 307 138 Cupriavidus basilensis OR16 P(β) H1S5P4 WP_006158738.1 147 Short-BLUF 308 139 Cupriavidus necator ATCC 17699 P(β) Q0JZS4 YP_841480.1 147 Short-BLUF 309 Cupriavidus necator ATCC 43291 P(β) F8GRM4 YP_004682121.1 147 Short-BLUF 310 140 Cupriavidus sp. BIS7 P(β) WP_019447941.1 147 Short-BLUF 311 Cupriavidus sp. HMR-1 P(β) L2ELR6 WP_008643847.1 147 Short-BLUF 312 Cupriavidus sp. HPC(L) P(β) K6B9H2 WP_006577586.1 147 Short-BLUF 313 Cupriavidus sp. UYPR2.512 P(β) WP_018308878.1 147 Short-BLUF 314 Cupriavidus sp. WS P(β) WP_020204073.1 147 Short-BLUF 315 141 Cupriavidus taiwanensis P(β) WP_018008408.1 147 Short-BLUF 316 Cupriavidus taiwanensis LMG 19424 P(β) B3RBI8 YP_002008317.1 147 Short-BLUF 317 142 Curvibacter lanceolatus P(β) WP_019576065.1 140 Short-BLUF 318 Curvibacter lanceolatus P(β) WP_019577548.1 140 Short-BLUF 319 143 Curvibacter putative symbiont of Hydra magnipapillata P(β) C9Y8H7 CBA27840.1 156 Short-BLUF 320 C9Y9E1 CBA28480.1 425 BLUF+EAL 321 C9YG67 CBA33160.1 77 Short-BLUF 322 144 Delftia acidovorans SPH-1 P(β) A9BX41 YP_001565411.1 133 Short-BLUF 323 145 Delftia sp. (strain Cs1-4) P(β) F6ALE0 YP_004488022.1 133 Short-BLUF 324 146 Duganella zoogloeoides P(β) WP_019920955.1 141 Short-BLUF 325 147 Herbaspirillum frisingense GSF30 P(β) R0FSP4 WP_006463383.1 141 Short-BLUF 326 148 Herbaspirillum lusitanum P(β) WP_016833369.1 141 Short-BLUF 327 149 Herbaspirillum seropedicae P(β) WP_017452789.1 141 Short-BLUF 328 Herbaspirillum seropedicae (strain SmR1) P(β) D8IY84 YP_003778114.1 141 Short-BLUF 329 150 Herbaspirillum sp. CF444 P(β) J3D4X2 WP_007882396.1 141 Short-BLUF 330 Herbaspirillum sp. GW103 P(β) I3CM34 WP_008333777.1 141 Short-BLUF 331 Herbaspirillum sp. YR522 P(β) J3CNJ7 WP_008112004.1 141 Short-BLUF 332 151 Herminiimonas arsenicoxydans P(β) A4G7R3 CAL62550.2 116 Short-BLUF 333 152 Hydrogenophaga sp. PBC P(β) WP_009520410.1 140 Short-BLUF 334 153 Janthinobacterium lividum P(β) WP_010396398.1 135 Short-BLUF 335 WP_010399694.1 141 Short-BLUF 336 154 Janthinobacterium sp. CG3 P(β) WP_017879051.1 136 Short-BLUF 337 155 Leptothrix cholodnii SP-6 P(β) B1XZW9 YP_001790861.1 141 Short-BLUF 338 156 Limnobacter sp. MED105 P(β) A6GT96 WP_008252022.1 157 Short-BLUF 339

A40

A6GT66 WP_008251962.1 134 Short-BLUF 340 157 Limnohabitans sp. Rim28 P(β) WP_019425978.1 147 Short-BLUF 341 WP_019426427.1 140 Short-BLUF 342 Limnohabitans sp. Rim47 P(β) WP_019429110.1 147 Short-BLUF 343 WP_019430089.1 140 Short-BLUF 344 158 Methylibium petroleiphilum (strain PM1) P(β) A2SEP7 YP_001020271.1 142 Short-BLUF 345 A2SHW7 YP_001021391.1 97 Short-BLUF 346 159 Methylotenera mobilis P(β) WP_019897538.1 138 Short-BLUF 347 WP_019896887.1 159 Short-BLUF 348 Methylotenera mobilis JLW8 P(β) C6WT83 YP_003049672.1 162 Short-BLUF 349 160 Methylotenera sp. 301 P(β) D7DKL3 YP_003675036.1 137 Short-BLUF 350 D7DLZ8 YP_003675269.1 199 Short-BLUF 351 161 Methyloversatilis sp. NVD P(β) WP_018410763.1 140 Short-BLUF 352 162 Methyloversatilis universalis P(β) WP_018230298.1 140 Short-BLUF 353 WP_020164190.1 147 Short-BLUF 354 WP_018229736.1 141 Short-BLUF 355 Methyloversatilis universalis FAM5 P(β) F5RDI2 WP_008061871.1 140 Short-BLUF 356 F5RC20 WP_008060661.1 141 Short-BLUF 357 163 Oxalobacteraceae bacterium IMCC9480 P(β) F1VUP6 WP_009664611.1 141 Short-BLUF 358 Oxalobacteraceae bacterium JGI 0001004-K23 P(β) WP_018058743.1 141 Short-BLUF 359 164 Polaromonas naphthalenivorans CJ2 P(β) A1VKQ2 YP_981151.1 140 Short-BLUF 360 A1VJM4 YP_980773.1 134 Short-BLUF 361 165 Polaromonas sp. CF318 P(β) J2LWR4 WP_007863266.1 135 Short-BLUF 362 J2U008 WP_007867959.1 140 Short-BLUF 363 J2UJU6 WP_007862374.1 135 Short-BLUF 364 Polaromonas sp. strain JS666 P(β) Q12F66 YP_547724.1 140 Short-BLUF 365 Q12FR6 YP_547524.1 135 Short-BLUF 366 166 Polynucleobacter necessarius STIR1 P(β) B1XTH8 YP_001797269.1 135 Short-BLUF 367 167 Polynucleobacter sp. QLW-P1DMWA-1 P(β) A4SVS3 YP_001155151.1 135 Short-BLUF 368 168 Pseudogulbenkiania ferrooxidans EGD-HP2 P(β) U1AEJ0 WP_021475086.1 141 Short-BLUF 369 169 Ralstonia eutropha H16 P(β) Q0JZS4 CAJ96750.1/YP_841480.1 147 Short-BLUF 370 Ralstonia eutropha JMP134 P(β) Q46V06 YP_297872.1 147 Short-BLUF 371 170 Ralstonia metallidurans CH34 P(β) Q1LG69 YP_586126.1 147 Short-BLUF 372 171 Ralstonia pickettii DTP0602 P(β) YP_008600000.1 147 Short-BLUF 373 172 Ralstonia sp. GA3-3 P(β) R7XF66 EON18032.1/YP_841480.1 147 Short-BLUF 374 173 Ramlibacter tataouinensis DSM 14655 P(β) F5XYH6 YP_004619171.1 225 Short-BLUF 375 F5XWS2 YP_004620235.1 140 Short-BLUF 376 174 Rhodocyclaceae bacterium RZ94 P(β) WP_019918775.1 144 Short-BLUF 377 175 Rhodoferax ferrireducens DSM 15236 P(β) Q21YW7 YP_522567.1 140 Short-BLUF 378 176 Rubrivivax benzoatilyticus JA2 P(β) F3LLG6 WP_009855751.1 141 Short-BLUF 379 F3LQM5 WP_009857208.1 187 Short-BLUF 380 177 Rubrivivax gelatinosus (strain NBRC 100245 / IL144) P(β) I0HNG0 YP_005436046.1 151 Short-BLUF 381 I0HXR5 YP_005439301.1 141 Short-BLUF 382 178 Thauera sp. 27 P(β) N6YS95 WP_002936113.1 779 PAS+GGDEF+EAL+BLUF 383 179 Thiomonas intermedia K12 P(β) D5X5X2 YP_003642355.1 159 Short-BLUF 384 180 Variovorax paradoxus P(β) WP_019654574.1 135 Short-BLUF 385 WP_019656584.1 140 Short-BLUF 386 Variovorax paradoxus (strain EPS) P(β) E6UYP4 YP_004157058.1 140 Short-BLUF 387 E6UZL0 YP_004155929.1 140 Short-BLUF 388

A41

E6UVP8 YP_004153392.1 134 Short-BLUF 389 Variovorax paradoxus B4 P(β) T1XG74 YP_008518022.1 140 Short-BLUF 390 Variovorax paradoxus S110 P(β) C5CWX4 YP_002945997.1 140 Short-BLUF 391 C5CNN1 YP_002942913.1 134 Short-BLUF 392 Variovorax sp. CF313 P(β) J2TF58 WP_007831506.1 138 Short-BLUF 393 WP_007837143.1 140 Short-BLUF 394 181 Verminephrobacter aporrectodeae P(β) WP_010101101.1 140 Short-BLUF 395 182 Verminephrobacter eiseniae strain EF01-2 P(β) A1WMH3 YP_997848.1 133 Short-BLUF 396 A1WHJ0 YP_996115.1 142 Short-BLUF 397 183 Acinetobacter P(γ) WP_017398952.1 147 Short-BLUF 398 184 Acinetobacter baumannii P(γ) B9UN50 ACJ61333.1 125 Short-BLUF 399 WP_000383195.1 156 Short-BLUF 400 WP_001102891.1 156 Short-BLUF 401 WP_019205050.1 110 Short-BLUF 402 Acinetobacter baumannii ATCC 17978 P(γ) A3M6V8 ABO12652.2/YP_001847089.1 156 Short-BLUF 403 Acinetobacter baumannii 6013113 P(γ) F5IG55 EGJ62365.1/YP_001713224.1 156 Short-BLUF 404 Acinetobacter baumannii 6013150 P(γ) F5I0V4 EGJ59752.1/YP_001713224.1 156 Short-BLUF 405 Acinetobacter baumannii 6014059 P(γ) F5INK0 EGJ67557.1/YP_001847089.1 156 Short-BLUF 406 Acinetobacter baumannii AA-014 P(γ) L9MMX8 ELW87667.1/YP_001847089.1 156 Short-BLUF 407 Acinetobacter baumannii AB0057 P(γ) B7IC80 YP_002319929.1 146 Short-BLUF 408 Acinetobacter baumannii Ab11111 P(γ) K1KNL6 EKB33264.1/YP_001847089.1 156 Short-BLUF 409 Acinetobacter baumannii AB210 P(γ) F5JQ04 EGK47564.1/YP_001847089.1 156 Short-BLUF 410 Acinetobacter baumannii AB307-0294 P(γ) B7H0C4 YP_002325120.1 156 Short-BLUF 411 Acinetobacter baumannii Ab33333 P(γ) K1L153 EKB37999.1/YP_001847089.1 156 Short-BLUF 412 Acinetobacter baumannii Ab44444 P(γ) K1LDN5 EKB42599.1/YP_001847089.1 156 Short-BLUF 413 Acinetobacter baumannii ABNIH1 P(γ) F9I778 EGT96279.1/YP_001847089.1 156 Short-BLUF 414 Acinetobacter baumannii ABNIH10 P(γ) M8FRG3 EMU01204.1/YP_001713224.1 156 Short-BLUF 415 Acinetobacter baumannii ABNIH11 P(γ) M8FCJ0 EMU03061.1/YP_001713224.1 156 Short-BLUF 416 Acinetobacter baumannii ABNIH13 P(γ) M8G623 EMU12871.1/YP_001847089.1 156 Short-BLUF 417 Acinetobacter baumannii ABNIH14 P(γ) M8G600 EMU15902.1/YP_001847089.1 156 Short-BLUF 418 Acinetobacter baumannii ABNIH15 P(γ) M8GPL3 EMU19730.1/YP_001847089.1 156 Short-BLUF 419 Acinetobacter baumannii ABNIH16 P(γ) M8HH59 EMU18738.1/YP_001847089.1 156 Short-BLUF 420 Acinetobacter baumannii ABNIH17 P(γ) M8I2R0 EMU36405.1/YP_001847089.1 156 Short-BLUF 421 Acinetobacter baumannii ABNIH18 P(γ) M8HM77 EMU34022.1/YP_001847089.1 156 Short-BLUF 422 Acinetobacter baumannii ABNIH19 P(γ) M8IIQ3 EMU31648.1/YP_001713224.1 156 Short-BLUF 423 Acinetobacter baumannii ABNIH2 P(γ) F9IL05 EGT94630.1/YP_001847089.1 156 Short-BLUF 424 Acinetobacter baumannii ABNIH20 P(γ) M8HYS5 EMU38102.1/YP_001847089.1 156 Short-BLUF 425 Acinetobacter baumannii ABNIH22 P(γ) M8IRW2 EMU37704.1/YP_001847089.1 156 Short-BLUF 426 Acinetobacter baumannii ABNIH23 P(γ) M8INV0 EMU43935.1/YP_001847089.1 156 Short-BLUF 427 Acinetobacter baumannii ABNIH24 P(γ) M8JP20 EMU48679.1/YP_001847089.1 156 Short-BLUF 428 Acinetobacter baumannii ABNIH25 P(γ) M8E8P5 EMT89469.1/YP_001847089.1 156 Short-BLUF 429 Acinetobacter baumannii ABNIH26 P(γ) M8ENA7 EMT84227.1/YP_001847089.1 156 Short-BLUF 430 Acinetobacter baumannii ABNIH3 P(γ) F9J0C3 EGT93760.1/YP_001847089.1 156 Short-BLUF 431 Acinetobacter baumannii ABNIH4 P(γ) F9J5J3 EGU03419.1/YP_001847089.1 156 Short-BLUF 432 Acinetobacter baumannii ABNIH5 P(γ) M8E7N4 EMT89085.1/YP_001847089.1 156 Short-BLUF 433 Acinetobacter baumannii ABNIH6 P(γ) M8FRA0 EMT97557.1/YP_001713224.1 156 Short-BLUF 434 Acinetobacter baumannii ABNIH7 P(γ) M8EIC5 EMT95636.1/YP_001713224.1 156 Short-BLUF 435 Acinetobacter baumannii AC12 P(γ) J2Z674 EJN44155.1/YP_001847089.1 156 Short-BLUF 436 Acinetobacter baumannii AC30 P(γ) K6HQG6 EKO44813.1/YP_001847089.1 156 Short-BLUF 437

A42

Acinetobacter baumannii ACICU P(γ) B2HUF8 YP_001847089.1 156 Short-BLUF 438 Acinetobacter baumannii ANC 4097 P(γ) N9KTG4 ENW69199.1/YP_001713224.1 156 Short-BLUF 439 Acinetobacter baumannii ATCC 19606 P(γ) D0C5R9 EEX04334.1/YP_007596771.1 156 Short-BLUF 440 Acinetobacter baumannii AYE P(γ) B0V7Y7 YP_001713224.1 156 Short-BLUF 441 Acinetobacter baumannii BJAB0715 P(γ) S5CPN1 YP_008217774.1 156 Short-BLUF 442 Acinetobacter baumannii Canada BC-5 P(γ) J4JC81 EJO38969.1/YP_001713224.1 156 Short-BLUF 443 Acinetobacter baumannii Canada BC1 P(γ) K6MXH5 EKP56108.1/YP_001713224.1 156 Short-BLUF 444 Acinetobacter baumannii D1279779 P(γ) M4QZE8 AGH36110.1/YP_007596771.1 156 Short-BLUF 445 Acinetobacter baumannii IS-116 P(γ) K1F8S0 EKA67743.1/YP_001847089.1 156 Short-BLUF 446 Acinetobacter baumannii IS-123 P(γ) J4ZJ36 EJO37798.1/WP_001102890.1 156 Short-BLUF 447 Acinetobacter baumannii IS-143 P(γ) K1F3U0 EKA73961.1/YP_001847089.1 156 Short-BLUF 448 Acinetobacter baumannii IS-235 P(γ) K5EGT2 EKK05136.1/YP_001713224.1 156 Short-BLUF 449 Acinetobacter baumannii IS-251 P(γ) K5EN29 EKK16599.1/YP_001713224.1 156 Short-BLUF 450 Acinetobacter baumannii IS-58 P(γ) K1F7X7 EKA77090.1/YP_001713224.1 156 Short-BLUF 451 Acinetobacter baumannii MDR-TJ P(γ) I1XZ18 AFI94904.1/YP_001847089.1 156 Short-BLUF 452 Acinetobacter baumannii MDR-ZJ06 P(γ) G2JJV4 YP_005526514.1/YP_001847089.1 156 Short-BLUF 453 Acinetobacter baumannii MSP4-16 P(γ) M2Z5Q5 EME56213.1/YP_007596771.1 156 Short-BLUF 454 Acinetobacter baumannii Naval-113 P(γ) K9C0B8 EKU64146.1/YP_001847089.1 156 Short-BLUF 455 Acinetobacter baumannii Naval-13 P(γ) K5PLW1 EKL51476.1/WP_001102890.1 156 Short-BLUF 456 Acinetobacter baumannii Naval-17 P(γ) J1MTN3 EJG29655.1/YP_001847089.1 156 Short-BLUF 457 Acinetobacter baumannii Naval-18 P(γ) J4UB75 EJP50580.1/WP_001102890.1 156 Short-BLUF 458 Acinetobacter baumannii Naval-2 P(γ) K6M6A9 EKP46927.1/YP_001847089.1 156 Short-BLUF 459 Acinetobacter baumannii Naval-21 P(γ) K6N8V9 EKP54045.1/YP_001713224.1 156 Short-BLUF 460 Acinetobacter baumannii Naval-57 P(γ) L9P2K2 ELX05830.1/YP_007596771.1 156 Short-BLUF 461 Acinetobacter baumannii Naval-72 P(γ) K5EE33 EKK13424.1/YP_001847089.1 156 Short-BLUF 462 Acinetobacter baumannii Naval-78 P(γ) L9NMD3 ELX00539.1/YP_001847089.1 156 Short-BLUF 463 Acinetobacter baumannii Naval-81 P(γ) K4YNM4 EJP60409.1/WP_001102890.1 156 Short-BLUF 464 Acinetobacter baumannii Naval-82 P(γ) K6NY26 EKP62400.1/YP_007596771.1 156 Short-BLUF 465 Acinetobacter baumannii Naval-83 P(γ) K5Q641 EKL58786.1/YP_001713224.1 156 Short-BLUF 466 Acinetobacter baumannii NIPH 1362 P(γ) N8TB24 ENU55812.1/YP_001847089.1 156 Short-BLUF 467 Acinetobacter baumannii NIPH 146 P(γ) N8TY29 ENU64868.1/WP_001102890.1 156 Short-BLUF 468 Acinetobacter baumannii NIPH 1669 P(γ) N8SXZ9 ENU51242.1/WP_001102890.1 156 Short-BLUF 469 Acinetobacter baumannii NIPH 1734 P(γ) N8V464 ENU77902/WP_001102890.1 156 Short-BLUF 470 Acinetobacter baumannii NIPH 190 P(γ) N8YYI1 ENV26434.1/YP_007596771.1 156 Short-BLUF 471 Acinetobacter baumannii NIPH 201 P(γ) N9GPE0 ENW36793.1/YP_001847089.1 156 Short-BLUF 472 Acinetobacter baumannii NIPH 2061 P(γ) N8UQL2 ENU72709.1/YP_001847089.1 156 Short-BLUF 473 Acinetobacter baumannii NIPH 24 P(γ) N8NHZ5 ENU14041.1/YP_001847089.1 156 Short-BLUF 474 Acinetobacter baumannii NIPH 290 P(γ) N9KFC5 ENW64524.1/YP_001713224.1 156 Short-BLUF 475 Acinetobacter baumannii NIPH 329 P(γ) N9IN83 ENW45510.1/WP_002132039.1 156 Short-BLUF 476 Acinetobacter baumannii NIPH 329 P(γ) N9II22 ENW43700.1/WP_004708845.1 147 Short-BLUF 477 Acinetobacter baumannii NIPH 335 P(γ) N9IRT6 ENW44164.1/YP_001847089.1 156 Short-BLUF 478 Acinetobacter baumannii NIPH 410 P(γ) S3TXG4 WP_016653868.1 156 Short-BLUF 479 Acinetobacter baumannii NIPH 527 P(γ) N9GQH5 ENW37177.1/YP_001713224.1 156 Short-BLUF 480 Acinetobacter baumannii NIPH 528 P(γ) N9JTB2 ENW57311.1/YP_001847089.1 156 Short-BLUF 481 Acinetobacter baumannii NIPH 60 P(γ) N8ZBA3 ENV30959/WP_001102890.1 156 Short-BLUF 482 Acinetobacter baumannii NIPH 601 P(γ) N9HY38 ENW52033.1/YP_007596771.1 156 Short-BLUF 483 Acinetobacter baumannii NIPH 615 P(γ) N8U9R8 ENU68973.1/WP_001102890.1 156 Short-BLUF 484 Acinetobacter baumannii NIPH 67 P(γ) N9J4Z4 WP_005131310.1 156 Short-BLUF 485 Acinetobacter baumannii NIPH 70 P(γ) N9KCX5 ENW63679.1/YP_001847089.1 156 Short-BLUF 486

A43

Acinetobacter baumannii NIPH 80 P(γ) N9L2Z3 WP_005138547.1 156 Short-BLUF 487 Acinetobacter baumannii OIFC0162 P(γ) K5ET94 EKK09161.1/WP_001102887.1 156 Short-BLUF 488 Acinetobacter baumannii OIFC021 P(γ) L9MFF6 ELW84997.1/WP_002049354.1 156 Short-BLUF 489 Acinetobacter baumannii OIFC021 P(γ) L9M8U5 ELW83379.1/WP_002050218.1 141 Short-BLUF 490 Acinetobacter baumannii OIFC032 P(γ) J5I903 EJP41595.1/WP_001102890.1 156 Short-BLUF 491 Acinetobacter baumannii OIFC035 P(γ) K6NZL3 EKP69017.1/WP_002132039.1 156 Short-BLUF 492 Acinetobacter baumannii OIFC035 P(γ) K6NTF7 EKP66878.1/WP_002050218.1 141 Short-BLUF 493 Acinetobacter baumannii OIFC047 P(γ) L9NCI1 ELW97145.1/WP_001102887.1 156 Short-BLUF 494 Acinetobacter baumannii OIFC065 P(γ) K6LT01 EKP36620.1/YP_001847089.1 156 Short-BLUF 495 Acinetobacter baumannii OIFC074 P(γ) K5Q9S4 EKL46135.1/YP_001713224.1 156 Short-BLUF 496 Acinetobacter baumannii OIFC087 P(γ) K6LPN9 EKP41027.1/WP_001102890.1 156 Short-BLUF 497 Acinetobacter baumannii OIFC098 P(γ) K5PV19 EKL41434.1/YP_001847089.1 156 Short-BLUF 498 Acinetobacter baumannii OIFC099 P(γ) K6LQV6 EKP41452.1/WP_001102890.1 156 Short-BLUF 499 Acinetobacter baumannii OIFC109 P(γ) J0TMG8 EJG27711.1/WP_001102890.1 156 Short-BLUF 500 Acinetobacter baumannii OIFC110 P(γ) K5RVQ7 EKL57522.1/YP_001847089.1 156 Short-BLUF 501 Acinetobacter baumannii OIFC111 P(γ) K6M4D7 EKP46227.1/YP_001847089.1 156 Short-BLUF 502 Acinetobacter baumannii OIFC137 P(γ) J0S923 EJG10461.1/WP_001102890.1 156 Short-BLUF 503 Acinetobacter baumannii OIFC143 P(γ) J0T757 EJG19269.1/WP_001102890.1 156 Short-BLUF 504 Acinetobacter baumannii OIFC180 P(γ) K5RHA5 EKL52712.1/YP_001847089.1 156 Short-BLUF 505 Acinetobacter baumannii OIFC189 P(γ) J0SZ83 EJG19316.1/YP_001847089.1 156 Short-BLUF 506 Acinetobacter baumannii OIFC338 P(γ) L9N142 ELW92889.1/YP_001847089.1 156 Short-BLUF 507 Acinetobacter baumannii strain 1656-2 P(γ) E8PHF0 YP_001847089.1 156 Short-BLUF 508 Acinetobacter baumannii TCDC-AB0715 P(γ) F0QKL9 YP_005799504.1/YP_001847089.1 156 Short-BLUF 509 Acinetobacter baumannii TYTH-1 P(γ) K0HGX0 AFU38785.1/YP_001847089.1 156 Short-BLUF 510 Acinetobacter baumannii WC-136 P(γ) K9CVT9 WP_002115327.1 156 Short-BLUF 511 Acinetobacter baumannii WC-136 P(γ) K9CRD3 WP_002115633.1 141 Short-BLUF 512 Acinetobacter baumannii WC-141 P(γ) K9A8F1 WP_009389951.1 156 Short-BLUF 513 Acinetobacter baumannii WC-141 P(γ) K8ZYY4 WP_009387234.1 141 Short-BLUF 514 Acinetobacter baumannii WC-323 P(γ) K9BIS2 EKU54817/WP_005230460.1 156 Short-BLUF 515 Acinetobacter baumannii WC-323 P(γ) K9BM26 WP_009511737.1 155 Short-BLUF 516 Acinetobacter baumannii WC-323 P(γ) K9B986 WP_009515481.1 147 Short-BLUF 517 Acinetobacter baumannii WC-323 P(γ) K9BC39 WP_009511693.1 149 Short-BLUF 518 Acinetobacter baumannii WC-348 P(γ) K9B241 EKU53718.1/WP_001102887.1 156 Short-BLUF 519 Acinetobacter baumannii WC-487 P(γ) K9AXM6 EKU51999/WP_006580584.1 156 Short-BLUF 520 Acinetobacter baumannii WC-487 P(γ) K9BLE6 EKU60294.1/WP_002050218.1 141 Short-BLUF 521 Acinetobacter baumannii WC-692 P(γ) K1ESG1 EKA71749.1/YP_001847089.1 156 Short-BLUF 522 Acinetobacter baumannii WC-A-694 P(γ) K6MFE1 EKP63369.1/WP_001102890.1 156 Short-BLUF 523 Acinetobacter baumannii WC-A-92 P(γ) L9M673 WP_001102886.1 156 Short-BLUF 524 Acinetobacter baumannii ZWS1122 P(γ) K2ILA9 EKE59799.1/YP_001847089.1 156 Short-BLUF 525 Acinetobacter baumannii ZWS1219 P(γ) K2HQ55 EKE59891.1/YP_001847089.1 156 Short-BLUF 526 185 Acinetobacter baylyi DSM 14961 = CIP 107474 P(γ) N9B659 YP_046740.1 155 Short-BLUF 527 N9BCT4 WP_004927632.1 148 Short-BLUF 528 N9BED0 YP_046178.1 149 Short-BLUF 529 N8ZXW2 WP_004927624.1 155 Short-BLUF 530 186 Acinetobacter beijerinckii ANC 3835 P(γ) N9FTS1 WP_005051584.1 157 Short-BLUF 531 N9F6Z4 WP_005055777.1 155 Short-BLUF 532 N9FJQ5 WP_005054245.1 138 Short-BLUF 533 N9FDZ0 WP_005055778.1 149 Short-BLUF 534 Acinetobacter beijerinckii CIP 110307 P(γ) N9FHE8 WP_005059436.1 157 Short-BLUF 535

A44

187 Acinetobacter bereziniae CIP 70.12 P(γ) N9F616 WP_005029839.1 155 Short-BLUF 536 N9F7L1 ENW00876.1/WP_004830862.1 147 Short-BLUF 537 N9DPW4 WP_005029837.1 149 Short-BLUF 538 Acinetobacter bereziniae NIPH 3 P(γ) N8YPM4 ENV21180.1/WP_004831317.1 155 Short-BLUF 539 N8YQK9 ENV21525.1/WP_004830862.1 147 Short-BLUF 540 N8YIN9 ENV21179.1/WP_004831316.1 149 Short-BLUF 541 188 Acinetobacter calcoaceticus P(γ) WP_017392001.1 156 Short-BLUF 542 WP_017392001.1 156 Short-BLUF 543 WP_017480957.1 89 Short-BLUF 544 Acinetobacter calcoaceticus (strain PHEA-2) P(γ) F0KGE8 YP_004995739.1 141 Short-BLUF 545 F0KII1 ADY82317.1/YP_004995999.1 156 Short-BLUF 546 Acinetobacter calcoaceticus ANC 3680 P(γ) N9EC09 WP_005039435.1 156 Short-BLUF 547 Acinetobacter calcoaceticus ANC 3811 P(γ) R8Y6J9 WP_016137597.1 156 Short-BLUF 548 R8Y874 WP_016138168.1 161 Short-BLUF 549 Acinetobacter calcoaceticus DSM 30006 = CIP 81.8 P(γ) N9F0B6 ENV98323.1/WP_004643428.1 156 Short-BLUF 550 Acinetobacter calcoaceticus NIPH 13 P(γ) N8PJK1 ENU09837.1/WP_004643428.1 156 Short-BLUF 551 Acinetobacter calcoaceticus RUH2202 P(γ) D0S286 WP_003650777.1 156 Short-BLUF 552 189 Acinetobacter gerneri P(γ) N8YFI2 WP_004871730.1 157 Short-BLUF 553 190 Acinetobacter guillouiae CIP 63.46 P(γ) N8S7G3 ENU59170.1/WP_004719325.1 142 Short-BLUF 554 N8THK4 ENU57977.1/WP_004721233.1 155 Short-BLUF 555 N8S437 WP_004721230.1 149 Short-BLUF 556 Acinetobacter guillouiae MSP4-18 P(γ) S3Z3U9 EPH37159.1/WP_004719325.1 142 Short-BLUF 557 S3ZKX5 EPH38960.1/WP_004721233.1 155 Short-BLUF 558 Acinetobacter guillouiae NIPH 991 P(γ) N8WUW8 WP_004822451.1 142 Short-BLUF 559 N8WXK7 WP_004820747.1 155 Short-BLUF 560 N8YB72 WP_004820748.1 149 Short-BLUF 561 191 Acinetobacter gyllenbergii P(γ) WP_023269848.1 147 Short-BLUF 562 WP_023269642.1 155 Short-BLUF 563 Acinetobacter gyllenbergii CIP 110306 P(γ) S3PY91 EPF83591.1/WP_016539987.1 155 Short-BLUF 564 S3PP26 EPF88044.1/WP_016540194.1 147 Short-BLUF 565 Acinetobacter gyllenbergii MTCC 11365 P(γ) S3YW62 EPH35666.1/WP_016539987.1 155 Short-BLUF 566 S3ZBX9 EPH35880.1/WP_016540194.1 147 Short-BLUF 567 192 Acinetobacter haemolyticus ATCC 19194 P(γ) D4XPD9 WP_004638534.1 128 Short-BLUF 568 Acinetobacter haemolyticus CIP 64.3 P(γ) N9F599 WP_005082086.1 141 Short-BLUF 569 Acinetobacter haemolyticus NIPH 261 P(γ) N9GP72 WP_005090981.1 141 Short-BLUF 570 193 Acinetobacter indicus ANC 4215 P(γ) S3N2L2 WP_016659098.1 144 Short-BLUF 571 194 Acinetobacter johnsonii ANC 3681 P(γ) N9CQ68 WP_004982048.1 141 Short-BLUF 572 Acinetobacter johnsonii CIP 64.6 P(γ) N8RTR2 WP_004696426.1 141 Short-BLUF 573 Acinetobacter johnsonii SH046 P(γ) D0SCH6 WP_005400678.1 156 Short-BLUF 574 195 Acinetobacter lwoffii P(γ) WP_010327040.1 141 Short-BLUF 575 WP_016806942.1 156 Short-BLUF 576 Acinetobacter lwoffii CIP 70.31 P(γ) N9HDC8 ENW29835.1/WP_004278796.1 143 Short-BLUF 577 N9H602 ENW27250.1/WP_005104921.1 157 Short-BLUF 578 N9G8Z9 WP_005102339.1 149 Short-BLUF 579 Acinetobacter lwoffii NCTC 5866 = CIP 64.10 P(γ) N9FL15 ENW23433.1/WP_005097246.1 143 Short-BLUF 580 N9FRT2 ENW25392.1/WP_004281912.1 157 Short-BLUF 581 Acinetobacter lwoffii NIPH 478 P(γ) N9GA40 WP_005106614.1 143 Short-BLUF 582 N9G1N1 ENW28923 /WP_004281912.1 157 Short-BLUF 583 Acinetobacter lwoffii NIPH 715 P(γ) N8TVU5 ENU62389.1/WP_004278796.1 143 Short-BLUF 584

A45

N8TZW9 ENU64062.1/WP_004729009.1 157 Short-BLUF 585 Acinetobacter lwoffii SH145 P(γ) D0SZQ9 EEY88544.1/WP_004281912.1 157 Short-BLUF 586 D0ST39 EEY90693.1/WP_004278796.1 143 Short-BLUF 587 196 Acinetobacter nectaris P(γ) WP_023272517.1 164 Short-BLUF 588 WP_023274063.1 154 Short-BLUF 589 197 Acinetobacter nosocomialis P(γ) WP_006581725.1 150 Short-BLUF 590 WP_017398279.1 158 Short-BLUF 591 WP_016804882.1 192 Short-BLUF 592 WP_017392774.1 158 Short-BLUF 593 Acinetobacter nosocomialis Ab22222 P(γ) K2PWD6 WP_006580584.1 156 Short-BLUF 594 K2PVW2 WP_006581982.1 147 Short-BLUF 595 Acinetobacter nosocomialis NIPH 2119 P(γ) N8RB52 ENU48161/WP_002049354.1 156 Short-BLUF 596 N8SP20 ENU47659.1/WP_004708845.1 147 Short-BLUF 597 Acinetobacter nosocomialis NIPH 386 P(γ) N8YWQ6 WP_004886335.1 156 Short-BLUF 598 N8YS47 ENV39612.1/WP_004708845.1 147 Short-BLUF 599 198 Acinetobacter oleivorans P(γ) WP_023274242.1 147 Short-BLUF 600 199 Acinetobacter parvus DSM 16617 = CIP 108168 P(γ) N8QCF2 WP_004682504.1 142 Short-BLUF 601 200 Acinetobacter pittii P(γ) WP_023187856.1 141 Short-BLUF 602 Acinetobacter pittii ANC 3678 P(γ) N9G3B5 WP_005068354.1 156 Short-BLUF 603 N9ENJ6 WP_005068879.1 147 Short-BLUF 604 Acinetobacter pittii ANC 4050 P(γ) R8YQG3 WP_016140521.1 156 Short-BLUF 605 R8YMS0 WP_016140719.1 147 Short-BLUF 606 Acinetobacter pittii ANC 4052 P(γ) R8YV96 WP_016145865.1 156 Short-BLUF 607 R8YV13 WP_016145659.1 147 Short-BLUF 608 Acinetobacter pittii CIP 70.29 P(γ) N9EKI1 YP_004995999.1 156 Short-BLUF 609 N9EKQ9 WP_005073889.1 147 Short-BLUF 610 201 Acinetobacter radioresistens P(γ) WP_017401064.1 208 Short-BLUF 611 WP_017401136.1 185 Short-BLUF 612 Acinetobacter radioresistens DSM 6976 P(γ) K6W0U9 WP_005404197.1 140 Short-BLUF 613 K6VGN5 ENV88969.1/WP_005025739.1 146 Short-BLUF 614 K6UYR6 WP_005025735.1 147 Short-BLUF 615 K6UIB5 WP_005025720.1 158 Short-BLUF 616 Acinetobacter radioresistens NIPH 2130 P(γ) N9E4V1 WP_005014499.1 146 Short-BLUF 617 N9DVX6 WP_005019483.1 146 Short-BLUF 618 N9E4J8 WP_005014506.1 147 Short-BLUF 619 Acinetobacter radioresistens SH164 P(γ) D0T1D2 EEY87475.1/WP_005014499.1 146 Short-BLUF 620 D0T5A8 EEY86881.1/WP_005019483.1 146 Short-BLUF 621 D0T1Y5 EEY87678.1/WP_005404197.1 140 Short-BLUF 622 D0T1A1 WP_005404152.1 152 Short-BLUF 623 D0T1D4 WP_005404170.1 154 Short-BLUF 624 D0T1E1 WP_005014522.1 118 Short-BLUF 625 Acinetobacter radioresistens SK82 P(γ) C6RNE8 EET82638.1/WP_005404197.1 140 Short-BLUF 626 C6RPU2 WP_005405185.1 148 Short-BLUF 627 C6RLZ1 EET83186.1/WP_005014522.1 118 Short-BLUF 628 C6RQ12 EET82088.1/WP_005019483.1 146 Short-BLUF 629 C6RLZ9 EET83194.1/WP_005014499.1 146 Short-BLUF 630 C6RLZ8 EET83193.1/WP_005014506.1 147 Short-BLUF 631 Acinetobacter radioresistens WC-A-157 P(γ) J4ZH05 WP_005405555.1 140 Short-BLUF 632 J4ZPX4 EJO37381.1/WP_005025739.1 146 Short-BLUF 633 J4Z2C2 WP_005407064.1 146 Short-BLUF 634

A46

J4JB98 WP_005405508.1 148 Short-BLUF 635 J4ZHC1 WP_005405601.1 158 Short-BLUF 636 202 Acinetobacter schindleri CIP 107287 P(γ) N9AFC9 WP_004892906.1 142 Short-BLUF 637 N8ZAE4 ENV45921.1/WP_004897488.1 156 Short-BLUF 638 Acinetobacter schindleri NIPH 900 P(γ) N8XZD8 ENV12748.1/WP_004815687.1 142 Short-BLUF 639 N8WNA0 WP_004813968.1 156 Short-BLUF 640 203 Acinetobacter soli CIP 110264 P(γ) N9BKH9 WP_004938488.1 155 Short-BLUF 641 N9A8X8 WP_004937197.1 148 Short-BLUF 642 N9BMU6 ENV57428.1/WP_004937200.1 148 Short-BLUF 643 N9BJV1 WP_004938129.1 155 Short-BLUF 644 N9A568 ENV56437.1/WP_004938066.1 152 Short-BLUF 645 Acinetobacter soli CIP 110264 P(γ) N9A5P2 ENV56587.1/WP_004938485.1 150 Short-BLUF 646 Acinetobacter soli NIPH 2899 P(γ) N9AFQ3 WP_004947954.1 155 Short-BLUF 647 N9AFF8 WP_004946942.1 148 Short-BLUF 648 N9BN22 ENV59724.1/WP_004937200.1 148 Short-BLUF 649 N9AFI2 ENV60082.1/WP_004938066.1 152 Short-BLUF 650 N9AGU9 ENV60181.1/WP_004938485.1 150 Short-BLUF 651 204 Acinetobacter sp. 93A2 P(γ) Q933L6 YP_046178.1 149 Short-BLUF 652 Acinetobacter sp. ADP1 P(γ) Q6FAI1 YP_046754.1 149 Short-BLUF 653 Q6FAJ5 CAG68918.1/YP_046740.1 155 Short-BLUF 654 Q6FAH9 YP_046756.1 163 Short-BLUF 655 Q7BC36 CAG68356.1/YP_046178.1 149 Short-BLUF 656 Acinetobacter sp. ANC 3880 P(γ) N9T085 ENX57062.1/WP_005189133.1 155 Short-BLUF 657 N9T0N2 ENX56900.1/WP_004807238.1 148 Short-BLUF 658 N9RGG2 ENX57063.1/WP_005189145.1 149 Short-BLUF 659 Acinetobacter sp. ANC 3929 P(γ) N9LK71 WP_005152839.1 147 Short-BLUF 660 Acinetobacter sp. ANC 3994 P(γ) N8QCC6 WP_004648902.1 145 Short-BLUF 661 Acinetobacter sp. ANC 4105 P(γ) N9MQW8 ENW92349.1/WP_005189133.1 155 Short-BLUF 662 N9L7C0 WP_005188667.1 148 Short-BLUF 663 N9MGG1 ENW92350.1/WP_005189145.1 149 Short-BLUF 664 Acinetobacter sp. ATCC 27244 P(γ) C0VK32 WP_008940976.1 141 Short-BLUF 665 Acinetobacter sp. CIP 101934 P(γ) N9NFB7 ENX00710.1/WP_004815687.1 142 Short-BLUF 666 N9NKY1 ENX03417.1/WP_004897488.1 156 Short-BLUF 667 Acinetobacter sp. CIP 101966 P(γ) N9P0F1 WP_005263266.1 143 Short-BLUF 668 N9NWM1 ENX25468/WP_005104921.1 157 Short-BLUF 669 Acinetobacter sp. CIP 102082 P(γ) N8WM85 ENU96377.1/WP_004757740.1 142 Short-BLUF 670 Acinetobacter sp. CIP 102129 P(γ) N8VLK0 WP_004761518.1 142 Short-BLUF 671 Acinetobacter sp. CIP 102136 P(γ) N9PPP9 WP_005252160.1 143 Short-BLUF 672 N9NCH2 ENX18668.1//WP_004729009.1 157 Short-BLUF 673 Acinetobacter sp. CIP 102143 P(γ) N9TH59 ENX62685.1/WP_004757740.1 142 Short-BLUF 674 Acinetobacter sp. CIP 102159 P(γ) N8U5M8 ENU82816.1/WP_004757740.1 142 Short-BLUF 675 Acinetobacter sp. CIP 102529 P(γ) N8UNT2 ENU89135.1/WP_004757740.1 142 Short-BLUF 676 Acinetobacter sp. CIP 102637 P(γ) N8XF19 WP_004799395.1 142 Short-BLUF 677 Acinetobacter sp. CIP 110321 P(γ) R9AZG9 WP_016163638.1 148 Short-BLUF 678 Acinetobacter sp. CIP 51.11 P(γ) N9MYK0 WP_005247271.1 143 Short-BLUF 679 N9N647 WP_005245564.1 157 Short-BLUF 680 Acinetobacter sp. CIP 53.82 P(γ) N9MHW6 WP_005178747.1 144 Short-BLUF 681 Acinetobacter sp. CIP 56.2 P(γ) N8XEK4 ENV07524.1/WP_004807238.1 148 Short-BLUF 682 Acinetobacter sp. CIP 64.2 P(γ) N9N2S2 WP_005241169.1 155 Short-BLUF 683

A47

N9PKT7 WP_005241451.1 147 Short-BLUF 684 N9PKB9 WP_005241167.1 148 Short-BLUF 685 Acinetobacter sp. CIP 64.7 P(γ) N9QVJ7 ENX30917.1/WP_004278796.1 143 Short-BLUF 686 N9QHH3 ENX26357.1/WP_004729009.1 157 Short-BLUF 687 Acinetobacter sp. CIP 70.18 P(γ) N9ST00 ENX57771.1/WP_005189133.1 155 Short-BLUF 688 N9T3L2 ENX57935.1/WP_004807238.1 148 Short-BLUF 689 Acinetobacter sp. CIP A162 P(γ) N8Q5C3 WP_004645416.1 143 Short-BLUF 690 N8Q0C9 ENU15332.1/WP_004281912.1 157 Short-BLUF 691 Acinetobacter sp. COS3 P(γ) WP_023013276.1 148 Short-BLUF 692 Acinetobacter sp. DR1 P(γ) D8JK77 YP_003732271.1 161 Short-BLUF 693 D8JFY6 YP_003731440.1 156 Short-BLUF 694 Acinetobacter sp. GG2 P(γ) WP_019458416.1 156 Short-BLUF 695 WP_019459106.1 161 Short-BLUF 696 Acinetobacter sp. HA P(γ) I4ZUE1 EIM39833.1/WP_004815687.1 142 Short-BLUF 697 I4ZQ16 WP_008306942.1 156 Short-BLUF 698 Acinetobacter sp. MDS7A P(γ) WP_019836199.1 157 Short-BLUF 699 Acinetobacter sp. NBRC 100985 P(γ) G7GFE4 WP_007482358.1 148 Short-BLUF 700 G7GDM0 WP_007481279.1 155 Short-BLUF 701 Acinetobacter sp. NIPH 1847 P(γ) N9NUS5 ENX05670.1/WP_005230460.1 156 Short-BLUF 702 N9MA43 WP_005230039.1 153 Short-BLUF 703 N9MAQ2 WP_005230366.1 147 Short-BLUF 704 N9NRU6 WP_005230037.1 149 Short-BLUF 705 Acinetobacter sp. NIPH 1859 P(γ) N9R7K2 WP_005270554.1 147 Short-BLUF 706 Acinetobacter sp. NIPH 1867 P(γ) N9R0C8 WP_005211997.1 155 Short-BLUF 707 N9SKL2 WP_005212260.1 148 Short-BLUF 708 N9SJJ0 WP_005211995.1 149 Short-BLUF 709 Acinetobacter sp. NIPH 2036 P(γ) S3T8J5 WP_016652452.1 147 Short-BLUF 710 Acinetobacter sp. NIPH 2100 P(γ) N9RFY9 WP_005293946.1 147 Short-BLUF 711 Acinetobacter sp. NIPH 2168 P(γ) N9Q857 WP_005257675.1 156 Short-BLUF 712 N9Q7N9 WP_005257454.1 147 Short-BLUF 713 Acinetobacter sp. NIPH 2171 P(γ) N9MH86 WP_005236029.1 143 Short-BLUF 714 N9MRD9 ENX11134/WP_004780330.1 156 Short-BLUF 715 N9MLJ6 ENX09453.1/WP_004782875.1 146 Short-BLUF 716 N9P2N4 WP_005235635.1 147 Short-BLUF 717 Acinetobacter sp. NIPH 3623 P(γ) N9RE67 ENX36920.1/WP_005230460.1 156 Short-BLUF 718 N9PWE1 WP_005285390.1 155 Short-BLUF 719 N9PX04 WP_005285742.1 147 Short-BLUF 720 N9PWA3 WP_005285387.1 149 Short-BLUF 721 Acinetobacter sp. NIPH 542 P(γ) N9RMM9 WP_005306937.1 156 Short-BLUF 722 N9QI40 WP_005305097.1 147 Short-BLUF 723 Acinetobacter sp. NIPH 713 P(γ) N9KUS9 ENW87773.1/WP_005097246.1 143 Short-BLUF 724 N9KN55 WP_005173613.1 149 Short-BLUF 725 Acinetobacter sp. NIPH 758 P(γ) N8UVT4 WP_004772199.1 156 Short-BLUF 726 N8W7V8 WP_004772105.1 147 Short-BLUF 727 Acinetobacter sp. NIPH 809 P(γ) N8QJS9 WP_004653704.1 155 Short-BLUF 728 N8QQ22 WP_004653401.1 147 Short-BLUF 729 N8QQ45 WP_004653706.1 149 Short-BLUF 730 Acinetobacter sp. NIPH 817 P(γ) N8VUX6 WP_004791296.1 156 Short-BLUF 731 N8VSG1 WP_004792481.1 161 Short-BLUF 732 Acinetobacter sp. NIPH 899 P(γ) N8WTX6 WP_004783886.1 143 Short-BLUF 733

A48

N8VMF9 ENV00711.1/WP_004780330.1 156 Short-BLUF 734 N8VIL1 ENU99395.1/WP_004782875.1 146 Short-BLUF 735 Acinetobacter sp. NIPH 973 P(γ) N8SCA4 WP_004700647.1 156 Short-BLUF 736 Acinetobacter sp. P8-3-8 P(γ) WP_010115938.1 149 Short-BLUF 737 Acinetobacter sp. RUH2624 P(γ) D0BZX2 EEX00046.1/WP_004708845.1 147 Short-BLUF 738 D0BX54 EEX01065.1/WP_006580584.1 156 Short-BLUF 739 Acinetobacter sp. SH024 P(γ) D6JU40 EFF86339.1/WP_002115327.1 156 Short-BLUF 740 D6JTD2 WP_005803474.1 147 Short-BLUF 741 Acinetobacter sp. WC-743 P(γ) L9MH55 ELW86565.1/WP_004831317.1 155 Short-BLUF 742 L9ME93 ELW84587.1/WP_004830862.1 147 Short-BLUF 743 L9ME60 WP_009585312.1 147 Short-BLUF 744 L9MHY5 ELW86514.1/WP_004831316.1 149 Short-BLUF 745 205 Acinetobacter tandoii DSM 14970 = CIP 107469 P(γ) R9B235 WP_016166413.1 140 Short-BLUF 746 206 Acinetobacter ursingii ANC 3649 P(γ) N9DFL6 WP_005004065.1 141 Short-BLUF 747 N9DGY2 WP_005002881.1 155 Short-BLUF 748 Acinetobacter ursingii DSM 16037 = CIP 107286 P(γ) N9D109 WP_004989315.1 141 Short-BLUF 749 N9D4M0 ENV75720.1/WP_004990933.1 155 Short-BLUF 750 Acinetobacter ursingii NIPH 706 P(γ) N9QSA7 WP_004997440.1 141 Short-BLUF 751 N9QT74 ENX49024.1/WP_004990933.1 155 Short-BLUF 752 207 Acinetobacter venetianus P(γ) WP_017196667.1 147 Short-BLUF 753 WP_019384317.1 148 Short-BLUF 754 Acinetobacter venetianus RAG-1 = CIP 110063 P(γ) N8ZT40 WP_004879195.1 148 Short-BLUF 755 208 Algicola sagamiensis P(γ) WP_018691603.1 138 Short-BLUF 756 WP_018694364.1 138 Short-BLUF 757 WP_018694365.1 140 Short-BLUF 758 209 Alishewanella agri BL06 P(γ) I9DUG2 WP_008983735.1 137 Short-BLUF 759 210 Alishewanella jeotgali KCTC 22429 P(γ) H3ZIX1 WP_008951845.1 137 Short-BLUF 760 211 Allochromatium vinosum DSM 180 P(γ) D3RRS9 YP_003443015.1 1124 PAS+GGDEF+EAL+BLUF 761 D3RMV8 YP_003444278.1 143 Short-BLUF 762 212 Alteromonadales bacterium TW-7 P(γ) A0XX52 WP_006791331.1 141 Short-BLUF 763 214 Alteromonas macleodii 'Deep ecotype' P(γ) F2G2W2 AEA96322.1/YP_004425320.1 390 BLUF+EAL 764 Alteromonas macleodii (strain Balearic Sea AD45) P(γ) K0EAG8 YP_006801094.1 395 BLUF+EAL 765 Alteromonas macleodii (strain Black Sea 11) P(γ) K0CTD4 YP_006823174.1 395 BLUF+EAL 766 Alteromonas macleodii (strain English Channel 673) P(γ) K0CJN8 YP_006797210.1 395 BLUF+EAL 767 Alteromonas macleodii AltDE1 P(γ) K7RG75 YP_004425320.1 390 BLUF+EAL 768 Alteromonas macleodii ATCC 27126 P(γ) J9Y701 YP_006746245.1 405 BLUF+EAL 769 Alteromonas macleodii str. 'Aegean Sea MED64' P(γ) S5ATU0 AGP80153.1 390 BLUF+EAL 770 Alteromonas macleodii str. 'Ionian Sea U4' P(γ) S5AU17 YP_008170230.1 405 BLUF+EAL 771 Alteromonas macleodii str. 'Ionian Sea U8' P(γ) S5BLE9 YP_008170230.1 405 BLUF+EAL 772 215 Beggiatoa sp. PS P(γ) A7BT71 EDN70265.1 350 BLUF+Cyclase 773 216 Bermanella marisrubri P(γ) Q1N3J0 WP_007018774.1 163 Short-BLUF 774 217 Cedecea davisae P(γ) WP_016535954.1 401 BLUF+EAL 775 218 Cellvibrio sp. BR P(γ) I3IDC4 WP_007638332.1 179 Short-BLUF 776 219 Citrobacter freundii 4_7_47CFAA P(γ) G9SK57 WP_003833502.1 409 BLUF+EAL 777 Citrobacter freundii ATCC 8090 = MTCC 1658 P(γ) K8QN37 WP_003841532.1 409 BLUF+EAL 778 Citrobacter freundii GTC 09479 P(γ) M3DUI2 WP_003844033.1 409 BLUF+EAL 779 Citrobacter freundii GTC 09629 P(γ) R1HFL0 EOD62395.1/WP_003020858.1 409 BLUF+EAL 780 220 Citrobacter rodentium (strain ICC168) P(γ) D2TIH4 YP_003365120.1 406 BLUF+ EAL 781 221 Citrobacter sp. 30_2 P(γ) C1M5D7 WP_008784992.1 409 BLUF+ EAL 782

A49

Citrobacter sp. A1 P(γ) J0M453 EJF22671.1/WP_003020858.1 409 BLUF+EAL 783 Citrobacter sp. KTE151 P(γ) R8WTE8 WP_016153346.1 403 BLUF+EAL 784 Citrobacter sp. KTE30 P(γ) R8UVC4 WP_016150366.1 409 BLUF+EAL 785 Citrobacter sp. KTE32 P(γ) R8V9S4 WP_016156768.1 403 BLUF+EAL 786 Citrobacter sp. L17 P(γ) K8ZLA8 EKU35574.1/WP_003020858.1 409 BLUF+EAL 787 222 Citrobacter youngae ATCC 29220 P(γ) D4B8N0 WP_006684233.1 403 BLUF+ EAL 788 223 Congregibacter litoralis KT71 P(γ)U A4A4X0 EAQ98841.1/WP_008294319.1 160 Short-BLUF 789 A4ACN4 WP_008296304.1 120 Short-BLUF 790 A4A4X0 EAQ98841.1/WP_008294319.1 160 Short-BLUF 791 224 Cronobacter dublinensis 1210 P(γ) K8AWY9 WP_007716320.1 404 BLUF+EAL 792 Cronobacter dublinensis 582 P(γ) K8AXH9 WP_007750072.1 404 BLUF+EAL 793 225 Cronobacter sakazakii E899 P(γ) F5VN29 WP_004387288.1 403 BLUF+EAL 794 226 Cronobacter turicensis 564 P(γ) K8BZ68 WP_007767450.1 362 BLUF+EAL 795 Cronobacter turicensis DSM 18703 / LMG 23827 / z3032 P(γ) C9XVD7 YP_003211056.1 404 BLUF+ EAL 796 C9Y5C1 YP_003212605.1 405 BLUF+ EAL 797 227 Ectothiorhodospira sp. PHS-1 P(γ) H1G5T1 WP_008932735.1 1090 PAS+GGDEF+EAL+BLUF 798 228 Endozoicomonas elysicola P(γ) WP_020581308.1 159 Short-BLUF 799 229 Enhydrobacter aerosaccus SK60 P(γ) C8PY76 WP_007116298.1 190 Short-BLUF 800 C8PVS3 WP_007115447.1 168 Short-BLUF 801 C8PY73 WP_007116295.1 143 Short-BLUF 802 C8Q1B6 WP_007117385.1 217 Short-BLUF 803 C8PX01 WP_007115875.1 192 Short-BLUF 804 C8PY74 WP_007116296.1 191 Short-BLUF 805 230 Enterobacter cloacae subsp. Cloacae strain ATCC 13047 P(γ) D5CBV1 YP_003612864.1 406 BLUF+ EAL 806 231 Enterobacter sp. 638 P(γ) A4WAH8 YP_001176759.1 406 BLUF+ EAL 807 A4W9Q6 YP_001176487.1/NP_415681.1 418 BLUF+ EAL 808 232 Enterobacter aerogenes P(γ) WP_020079328.1 403 BLUF+EAL 809 Enterobacter aerogenes ATCC 13048 P(γ) G0EBP4 YP_004593064.1 403 BLUF+EAL 810 Enterobacter aerogenes EA1509E P(γ) L8BJB1 YP_007388638.1 403 BLUF+EAL 811 233 Enterobacter asburiae (strain LF7a) P(γ) G2SAH3 YP_004828302.1 406 BLUF+EAL 812 G2S426 YP_004828705.1 404 BLUF+EAL 813 234 Enterobacter cancerogenus ATCC 35316 P(γ) D2ZBH9 WP_006174898.1 406 BLUF+ EAL 814 235 Enterobacter cloacae P(γ) WP_023305984.1 406 BLUF+EAL 815 WP_023299928.1 406 BLUF+EAL 816 WP_023311325.1 406 BLUF+EAL 817 WP_023478840.1 410 BLUF+EAL 818 WP_017457087.1 407 BLUF+EAL 819 WP_017456801.1 406 BLUF+EAL 820 236 Enterobacter cloacae complex P(γ) WP_022647870.1 406 BLUF+EAL 821 WP_023292651.1 406 BLUF+EAL 822 Enterobacter cloacae EC_38VIM1 P(γ) S9ZFC8 WP_021241106.1 406 BLUF+EAL 823 Enterobacter cloacae EcWSU1 P(γ) G8LLE0 YP_004951716.1 406 BLUF+EAL 824 237 Enterobacter cloacae subsp. cloacae ENHKU01 P(γ) J7GAN8 YP_006578373.1 406 BLUF+EAL 825 Enterobacter cloacae subsp. cloacae GS1 P(γ) I4ZKI1 WP_003857746.1 406 BLUF+EAL 826 Enterobacter cloacae subsp. Cloacae NCTC 9394 P(γ) D6DT37 YP_007845256.1 406 BLUF+ EAL 827 238 Enterobacter cloacae subsp. dissolvens SDM P(γ) I6SD99 YP_006477315.1 406 BLUF+EAL 828 239 Enterobacter hormaechei ATCC 49162 P(γ) F5RSE2 WP_006809041.1 406 BLUF+EAL 829 240 Enterobacter mori P(γ) WP_010430222.1 406 BLUF+EAL 830 241 Enterobacter radicincitans DSM 16656 P(γ) J1QQB0 WP_007375061.1 413 BLUF+EAL 831

A50

242 Enterobacter sakazakii ATCC BAA-894 P(γ) A7MRH4 YP_001440495.1 406 BLUF+ EAL 832 A7MJM6 YP_001437322.1 403 BLUF+ EAL 833 243 Enterobacter sp. Ag1 P(γ) J0W5B8 WP_008456677.1 396 BLUF+EAL 834 Enterobacter sp. MGH 14 P(γ) WP_022650917.1 406 BLUF+EAL 835 WP_023335406.1 406 BLUF+EAL 836 WP_023327186.1 406 BLUF+EAL 837 Enterobacter sp. R4-368 P(γ) R9VFU3 YP_008106092.1 407 BLUF+EAL 838 Enterobacter sp. SST3 P(γ) K4YIM7 WP_008500633.1 406 BLUF+EAL 839 244 Enterobacteriaceae bacterium LSJC7 P(γ) WP_017372627.1 408 BLUF+EAL 840 245 Enterovibrio calviensis P(γ) WP_017010526.1 136 Short-BLUF 841 246 Enterovibrio norvegicus P(γ) WP_017003299.1 138 Short-BLUF 842 WP_016960395.1 138 Short-BLUF 843 WP_017004081.1 138 Short-BLUF 844 WP_016961429.1 136 Short-BLUF 845 247 Erwinia billingiae (strain Eb661) P(γ) D8MSM3 YP_003741677.1 405 BLUF+EAL 846 248 Erwinia tasmaniensis Et1/99 P(γ) B2VD82 YP_001906720.1 399 BLUF+ EAL 847 249 Escherichia coli P(γ) E2QKT5 YP_002556088.1/NP_753514.1 429 BLUF+EAL 848 Escherichia coli P(γ) WP_001391600.1 240 BLUF+EAL 849 Escherichia coli P(γ) WP_001468594.1 403 BLUF+EAL 850 Escherichia coli P(γ) WP_001361917.1 403 BLUF+EAL 851 Escherichia coli P(γ) WP_004015500.1 403 BLUF+EAL 852 Escherichia coli P(γ) WP_001743620.1 403 BLUF+EAL 853 Escherichia coli P(γ) WP_001740380.1 373 BLUF+EAL 854 Escherichia coli P(γ) WP_001718133.1 403 BLUF+EAL 855 Escherichia coli P(γ) WP_001698260.1 403 BLUF+EAL 856 Escherichia coli P(γ) WP_001691539.1 403 BLUF+EAL 857 Escherichia coli P(γ) WP_001695881.1 403 BLUF+EAL 858 Escherichia coli P(γ) WP_001687453.1 403 BLUF+EAL 859 Escherichia coli P(γ) WP_001465306.1 373 BLUF+EAL 860 Escherichia coli P(γ) WP_001355660.1 403 BLUF+EAL 861 Escherichia coli P(γ) WP_001295665.1 403 BLUF+EAL 862 Escherichia coli P(γ) WP_000958311.1 417 BLUF+EAL 863 Escherichia coli P(γ) WP_000958300.1 421 BLUF+EAL 864 Escherichia coli P(γ) WP_000958297.1 395 BLUF+EAL 865 Escherichia coli P(γ) WP_000958288.1 107 Short-BLUF 866 Escherichia coli P(γ) WP_001620330.1 403 BLUF+EAL 867 Escherichia coli P(γ) WP_001612829.1 403 BLUF+EAL 868 Escherichia coli P(γ) WP_001607239.1 403 BLUF+EAL 869 Escherichia coli P(γ) WP_001602271.1 403 BLUF+EAL 870 Escherichia coli P(γ) WP_001599720.1 403 BLUF+EAL 871 Escherichia coli P(γ) WP_001595014.1 403 BLUF+EAL 872 Escherichia coli P(γ) WP_001578179.1 403 BLUF+EAL 873 Escherichia coli P(γ) WP_001569733.1 169 Short-BLUF 874 Escherichia coli P(γ) WP_001568725.1 403 BLUF+EAL 875 Escherichia coli P(γ) WP_001555889.1 403 BLUF+EAL 876 Escherichia coli P(γ) WP_001554913.1 403 BLUF+EAL 877 Escherichia coli P(γ) WP_001552806.1 403 BLUF+EAL 878 Escherichia coli P(γ) WP_001544512.1 403 BLUF+EAL 879 Escherichia coli P(γ) WP_001538632.1 403 BLUF+EAL 880

A51

Escherichia coli P(γ) WP_001536901.1 403 BLUF+EAL 881 Escherichia coli P(γ) WP_001522901.1 403 BLUF+EAL 882 Escherichia coli P(γ) WP_001524539.1 403 BLUF+EAL 883 Escherichia coli P(γ) WP_001446235.1 403 BLUF+EAL 884 Escherichia coli P(γ) WP_001445544.1 403 BLUF+EAL 885 Escherichia coli P(γ) WP_000958292.1 154 Short-BLUF 886 Escherichia coli P(γ) WP_001374958.1 403 BLUF+EAL 887 Escherichia coli P(γ) WP_001370660.1 403 BLUF+EAL 888 Escherichia coli P(γ) WP_000243125.1 429 BLUF+EAL 889 Escherichia coli P(γ) WP_001437392.1 403 BLUF+EAL 890 Escherichia coli P(γ) WP_001433282.1 403 BLUF+EAL 891 Escherichia coli P(γ) WP_001429147.1 403 BLUF+EAL 892 Escherichia coli P(γ) WP_001419806.1 403 BLUF+EAL 893 Escherichia coli P(γ) WP_001386209.1 403 BLUF+EAL 894 Escherichia coli P(γ) WP_001362180.1 403 BLUF+EAL 895 Escherichia coli P(γ) WP_001366263.1 403 BLUF+EAL 896 Escherichia coli P(γ) WP_001358810.1 403 BLUF+EAL 897 Escherichia coli P(γ) WP_001357463.1 403 BLUF+EAL 898 Escherichia coli P(γ) WP_001317774.1 403 BLUF+EAL 899 Escherichia coli P(γ) WP_001312754.1 403 BLUF+EAL 900 Escherichia coli P(γ) WP_001348052.1 403 BLUF+EAL 901 Escherichia coli P(γ) WP_001328999.1 403 BLUF+EAL 902 Escherichia coli P(γ) WP_001324491.1 403 BLUF+EAL 903 Escherichia coli P(γ) WP_001328624.1 403 BLUF+EAL 904 Escherichia coli P(γ) WP_001308583.1 403 BLUF+EAL 905 Escherichia coli P(γ) WP_001307726.1 403 BLUF+EAL 906 Escherichia coli P(γ) WP_001463330.1 403 BLUF+EAL 907 Escherichia coli P(γ) WP_023158058.1 405 BLUF+EAL 908 Escherichia coli P(γ) WP_023146755.1 403 BLUF+EAL 909 Escherichia coli P(γ) WP_022645540.1 403 BLUF+EAL 910 Escherichia coli P(γ) WP_023356384.1 403 BLUF+EAL 911 Escherichia coli P(γ) WP_023307905.1 403 BLUF+EAL 912 Escherichia coli P(γ) WP_023146272.1 250 BLUF 913 Escherichia coli P(γ) WP_023154785.1 408 BLUF+EAL 914 Escherichia coli P(γ) WP_021559105.1 403 BLUF+EAL 915

Escherichia coli

P(γ) WP_021577349.1 403 BLUF+EAL

916 Escherichia coli P(γ) WP_021576129.1 403 BLUF+EAL 917 Escherichia coli P(γ) WP_021573430.1 403 BLUF+EAL 918 Escherichia coli P(γ) WP_021565763.1 403 BLUF+EAL 919 Escherichia coli P(γ) WP_021565021.1 403 BLUF+EAL 920 Escherichia coli P(γ) WP_021556714.1 403 BLUF+EAL 921 Escherichia coli P(γ) WP_021555271.1 403 BLUF+EAL 922 Escherichia coli P(γ) WP_021545114.1 425 BLUF+EAL 923 Escherichia coli P(γ) WP_021535563.1 342 BLUF+EAL 924 Escherichia coli P(γ) WP_021529521.1 403 BLUF+EAL 925 Escherichia coli P(γ) WP_021527398.1 400 BLUF+EAL 926 Escherichia coli P(γ) WP_021524037.1 403 BLUF+EAL 927

A52

Escherichia coli P(γ) WP_020232864.1 403 BLUF+EAL 928 Escherichia coli P(γ) WP_020232494.1 412 BLUF+EAL 929 Escherichia coli P(γ) WP_020231333.1 403 BLUF+EAL 930 Escherichia coli P(γ) WP_016236982.1 210 Short-BLUF 931 Escherichia coli P(γ) WP_016238372.1 403 BLUF+EAL 932 Escherichia coli P(γ) WP_001661214.1 403 BLUF+EAL 933 Escherichia coli P(γ) WP_001658104.1 403 BLUF+EAL 934 Escherichia coli P(γ) WP_001654201.1 403 BLUF+EAL 935 Escherichia coli P(γ) WP_001637794.1 403 BLUF+EAL 936 Escherichia coli P(γ) WP_001596413.1 403 BLUF+EAL 937 Escherichia coli P(γ) WP_001500094.1 286 Short-BLUF 938 Escherichia coli P(γ) WP_001498311.1 138 Short-BLUF 939 Escherichia coli P(γ) WP_001413030.1 403 BLUF+EAL 940 Escherichia coli P(γ) WP_000958306.1 403 BLUF+EAL 941 Escherichia coli (protein YCGF) P(γ) Q2LD83 NP_415681.1 403 BLUF+ EAL 942 Escherichia coli (strain 'clone D i14') P(γ) G7RPK6 YP_006153556.1/NP_753514.1 429 BLUF+EAL 943 Escherichia coli (strain 'clone D i2') P(γ) G7R214 YP_006148637.1/NP_753514.1 429 BLUF+EAL 944 Escherichia coli (strain ATCC 55124 / KO11) P(γ) E8YDG2 YP_005278355.1/NP_415681.1 403 BLUF+EAL 945 Escherichia coli (strain ATCC 9637 ) P(γ) E0IV99 YP_006123985.1/NP_415681.1 403 BLUF+EAL 946 Escherichia coli (strain K12) P(γ) P75990 NP_415681.1 403 BLUF+EAL 947 Escherichia coli (strain UM146) P(γ) E1RSI8 YP_006111136.1/NP_415681.1 403 BLUF+EAL 948 Escherichia coli (strain UTI89 / UPEC) P(γ) Q1RCT6 YP_540359.1 429 BLUF+ EAL 949 Escherichia coli 042 P(γ) YP_006095522.1 429 BLUF+EAL 950 Escherichia coli 178850 P(γ) N4NL03 WP_001373149.1 258 Short-BLUF 951 Escherichia coli 179100 P(γ) N3IGZ9 WP_001504199.1 371 BLUF+EAL 952 Escherichia coli 1827-70 P(γ) E2WUJ4 WP_000958293.1 203 Short-BLUF 953 Escherichia coli 2362-75 P(γ) E3XMI4 WP_001339576.1 372 BLUF+EAL 954 Escherichia coli 2534-86 P(γ) G1Z313 YP_008564297.1/NP_415681.1 403 BLUF+EAL 955 Escherichia coli 2722950 P(γ) N2FEM7 WP_001737956.1 403 BLUF+EAL 956 Escherichia coli 2747800 P(γ) M9CTP4 EMW77468.1/WP_001620704.1 373 BLUF+EAL 957 Escherichia coli 2756500 P(γ) M9CF46 WP_001729927.1 403 BLUF+EAL 958 Escherichia coli 2848050 P(γ) M8ZHS3 WP_001716462.1 403 BLUF+EAL 959 Escherichia coli 3003 P(γ) I2YWE3 EII85154.1/YP_002328824.1 403 BLUF+EAL 960 Escherichia coli 3030-1 P(γ) G1ZHP6 EGW89164.1/NP_415681.1 403 BLUF+EAL 961 Escherichia coli 3431 P(γ) E6B8L1 NP_415681.1 403 BLUF+EAL 962 Escherichia coli 536 P(γ) YP_669112.1 403 BLUF+EAL 963 Escherichia coli 55989 P(γ) YP_002402341.1 403 BLUF+EAL 964 Escherichia coli 55989 P(γ) B7LGR8 NP_415681.1 403 BLUF+ EAL 965 Escherichia coli 83972 P(γ) C2DS59 NP_415681.1 403 BLUF+ EAL 966 Escherichia coli AA86 P(γ) F5MCT4 NP_415681.1 403 BLUF+EAL 967 Escherichia coli AI27 P(γ) I1BDH2 EIE56793.1/WP_000243121.1 429 BLUF+EAL 968 Escherichia coli ARS4.2123 P(γ) K3IWY5 EKI29918.1/YP_002328824.1 403 BLUF+EAL 969 Escherichia coli ATCC 33849 / DSM 4235 P(γ) C9QYF1 NP_415681.1 403 BLUF+ EAL 970 Escherichia coli ATCC 8739 / DSM 1576 P(γ) B1IUC7 NP_415681.1 403 BLUF+ EAL 971 Escherichia coli B / BL21 P(γ) C5W442 NP_415681.1 403 BLUF+ EAL 972 Escherichia coli B str. REL606 P(γ) C6UG31 NP_415681.1 403 BLUF+ EAL 973 Escherichia coli B088 P(γ) D6HVN5 NP_415681.1 403 BLUF+ EAL 974 Escherichia coli B093 P(γ) H1DQ46 EHO01026.1/WP_001330601.1 403 BLUF+EAL 975 Escherichia coli B171 P(γ) B3WRP4 NP_415681.1 403 BLUF+ EAL 976

A53

Escherichia coli B185 P(γ) D6I668 NP_415681.1 403 BLUF+ EAL 977 Escherichia coli B354 P(γ) D6J9C2 NP_415681.1 403 BLUF+ EAL 978 Escherichia coli B7A P(γ) B3HJB2 NP_415681.1 403 BLUF+ EAL 979 Escherichia coli BL21(DE3) P(γ) C6EGV1 NP_415681.1 403 BLUF+ EAL 980 Escherichia coli BW2952 P(γ) C4ZS80 NP_415681.1 403 BLUF+ EAL 981 Escherichia coli cloneA_i1 P(γ) G5KLP3 NP_415681.1 403 BLUF+EAL 982 Escherichia coli DEC10A P(γ) H5DHS1 NP_415681.1 403 BLUF+EAL 983 Escherichia coli DEC10B P(γ) H5E006 NP_415681.1 403 BLUF+EAL 984 Escherichia coli DEC10C P(γ) H5EGS7 NP_415681.1 403 BLUF+EAL 985 Escherichia coli DEC10D P(γ) H5EXJ1 WP_001422010.1 261 Short-BLUF 986 Escherichia coli DEC10E P(γ) H5FCY8 NP_415681.1 403 BLUF+EAL 987 Escherichia coli DEC11A P(γ) H5GAH5 NP_415681.1 403 BLUF+EAL 988 Escherichia coli DEC11B P(γ) H5GRQ2 NP_415681.1 403 BLUF+EAL 989 Escherichia coli DEC11C P(γ) H5H5Q9 NP_415681.1 403 BLUF+EAL 990 Escherichia coli DEC11D P(γ) H5HNB4 NP_415681.1 403 BLUF+EAL 991 Escherichia coli DEC11E P(γ) H5I2D6 NP_415681.1 403 BLUF+EAL 992 Escherichia coli DEC12A P(γ) H5IHF5 NP_415681.1 403 BLUF+EAL 993 Escherichia coli DEC12B P(γ) H5IZB9 NP_415681.1 403 Short-BLUF 994 Escherichia coli DEC12C P(γ) H5JGE4 NP_415681.1 403 BLUF+EAL 995 Escherichia coli DEC12D P(γ) H5JXD2 NP_415681.1 403 BLUF+EAL 996 Escherichia coli DEC12E P(γ) H5KCA3 NP_415681.1 403 BLUF+EAL 997 Escherichia coli DEC13A P(γ) H5KRY6 NP_415681.1 403 BLUF+EAL 998 Escherichia coli DEC13B P(γ) H5L5W5 NP_415681.1 403 BLUF+EAL 999 Escherichia coli DEC13C P(γ) H5LK42 NP_415681.1 403 BLUF+EAL 1000 Escherichia coli DEC13D P(γ) H5LZX0 NP_415681.1 403 BLUF+EAL 1001 Escherichia coli DEC13E P(γ) H5MDZ1 WP_001339576.1 381 BLUF+EAL 1002 Escherichia coli DEC14A P(γ) H5MTG4 NP_415681.1 403 BLUF+EAL 1003 Escherichia coli DEC14B P(γ) H5N8E5 NP_415681.1 403 BLUF+EAL 1004 Escherichia coli DEC14C P(γ) H5NN30 WP_001379733.1 372 BLUF+EAL 1005 Escherichia coli DEC14D P(γ) H5P346 NP_415681.1 403 BLUF+EAL 1006 Escherichia coli DEC15A P(γ) H5PIC2 NP_415681.1 403 BLUF+EAL 1007 Escherichia coli DEC15B P(γ) H5PXP2 NP_415681.1 403 BLUF+EAL 1008 Escherichia coli DEC15C P(γ) H5QCW6 WP_001339576.1 372 BLUF+EAL 1009 Escherichia coli DEC15D P(γ) H5QSM1 NP_415681.1 403 BLUF+EAL 1010 Escherichia coli DEC15E P(γ) H5R7T0 NP_415681.1 403 BLUF+EAL 1011 Escherichia coli DEC1A P(γ) H4HV06 WP_001339576.1 372 BLUF+EAL 1012 Escherichia coli DEC1B P(γ) H4I9V2 NP_415681.1 403 BLUF+EAL 1013 Escherichia coli DEC1C P(γ) H4IQ81 NP_415681.1 403 BLUF+EAL 1014 Escherichia coli DEC1D P(γ) H4J754 NP_415681.1 403 BLUF+EAL 1015 Escherichia coli DEC1E P(γ) H4JKR0 WP_001339576.1 372 BLUF+EAL 1016 Escherichia coli DEC2A P(γ) H4K1Y1 WP_001410290.1 261 Short-BLUF 1017 Escherichia coli DEC2B P(γ) H3KN36 NP_415681.1 403 BLUF+EAL 1018 Escherichia coli DEC2C P(γ) H4KF73 WP_001410290.1 261 Short-BLUF 1019 Escherichia coli DEC2D P(γ) H4KZ77 NP_415681.1 403 BLUF+EAL 1020 Escherichia coli DEC2E P(γ) H4LAN7 NP_415681.1 403 BLUF+EAL 1021 Escherichia coli DEC3F P(γ) H4P354 EHU91294.1/YP_006158540.1 403 BLUF+EAL 1022 Escherichia coli DEC5A P(γ) H4S987 WP_001417812.1 44 Short-BLUF 1023 Escherichia coli DEC5B P(γ) H4SPW0 WP_001418500.1 75 Short-BLUF 1024 Escherichia coli DEC5C P(γ) H4T6P3 EHV41042.1/YP_006158540.1 403 BLUF+EAL 1025

A54

Escherichia coli DEC5D P(γ) H4TM31 WP_001419416.1 372 BLUF+EAL 1026 Escherichia coli DEC5E P(γ) H4U0V1 NP_415681.1 403 BLUF+EAL 1027 Escherichia coli DEC6A P(γ) H4UHN0 NP_415681.1 403 BLUF+EAL 1028 Escherichia coli DEC6B P(γ) H4UYZ3 NP_415681.1 403 BLUF+EAL 1029 Escherichia coli DEC6C P(γ) H4VEK7 WP_001422010.1 261 Short-BLUF 1030 Escherichia coli DEC6D P(γ) H4VUU4 NP_415681.1 403 BLUF+EAL 1031 Escherichia coli DEC6E P(γ) H4W991 NP_415681.1 403 BLUF+EAL 1032 Escherichia coli DEC7A P(γ) H4WPY9 WP_001423841.1 386 BLUF+EAL 1033 Escherichia coli DEC7B P(γ) H4X4A0 NP_415681.1 403 BLUF+EAL 1034 Escherichia coli DEC7C P(γ) H4XJ12 NP_415681.1 403 BLUF+EAL 1035 Escherichia coli DEC7D P(γ) H4XZW2 NP_415681.1 403 BLUF+EAL 1036 Escherichia coli DEC7E P(γ) H4YEQ8 WP_001425462.1 372 BLUF+EAL 1037 Escherichia coli DEC8A P(γ) H4YUP5 WP_001425462.1 372 BLUF+EAL 1038 Escherichia coli DEC8B P(γ) H4ZC69 WP_001425462.1 372 BLUF+EAL 1039 Escherichia coli DEC8C P(γ) H4ZUJ6 NP_415681.1 403 BLUF+EAL 1040 Escherichia coli DEC8D P(γ) H5ABU3 NP_415681.1 403 BLUF+EAL 1041 Escherichia coli DEC8E P(γ) H5ASV4 NP_415681.1 403 BLUF+EAL 1042 Escherichia coli DEC9A P(γ) H5B8B5 NP_415681.1 403 BLUF+EAL 1043 Escherichia coli DEC9B P(γ) H5BP36 NP_415681.1 403 BLUF+EAL 1044 Escherichia coli DEC9C P(γ) H5C4S5 WP_001425462.1 372 BLUF+EAL 1045 Escherichia coli DEC9D P(γ) H5CJX7 NP_415681.1 403 BLUF+EAL 1046 Escherichia coli DEC9E P(γ) H5D173 NP_415681.1 403 BLUF+EAL 1047 Escherichia coli DH10B P(γ) B1XA50 NP_415681.1 403 BLUF+ EAL 1048 Escherichia coli E101 P(γ) H1E3B0 NP_415681.1 403 BLUF+EAL 1049 Escherichia coli E110019 P(γ) B3ISH0 WP_001299924.1 403 BLUF+ EAL 1050 Escherichia coli E1167 P(γ) E9W5A9 NP_415681.1 403 BLUF+EAL 1051 Escherichia coli E128010 P(γ) E7HSJ0 WP_000958298.1 417 BLUF+EAL 1052 E7HNP6 NP_415681.1 403 BLUF+EAL 1053 Escherichia coli E1520 P(γ) E9WDJ1 WP_000958294.1 197 Short-BLUF 1054 Escherichia coli E22 P(γ) B3ICE9 NP_415681.1 403 BLUF+ EAL 1055 Escherichia coli E24377A P(γ) A7ZKT0 NP_415681.1 403 BLUF+ EAL 1056 Escherichia coli E482 P(γ) E9WRS0 NP_415681.1 403 BLUF+EAL 1057 Escherichia coli EC4100B P(γ) E7UMM1 NP_415681.1 403 BLUF+EAL 1058 Escherichia coli ED1a P(γ) B7MTT9 NP_415681.1 403 BLUF+ EAL 1059 Escherichia coli EPECa14 P(γ) E7HK90 NP_415681.1 403 BLUF+EAL 1060 Escherichia coli F11 P(γ) B3HNR5 NP_415681.1 403 BLUF+ EAL 1061 Escherichia coli FVEC1302 P(γ) D7JMN5 NP_415681.1 403 BLUF+ EAL 1062 Escherichia coli FVEC1412 P(γ) D6IP27 NP_415681.1 403 BLUF+ EAL 1063 Escherichia coli G58-1 P(γ) G2B830 WP_001379733.1 372 BLUF+EAL 1064 Escherichia coli H252 P(γ) E9VF91 NP_415681.1 403 BLUF+EAL 1065 Escherichia coli H263 P(γ) E9VWR7 NP_415681.1 403 BLUF+EAL 1066 Escherichia coli H299 P(γ) F4VTS9 NP_415681.1 403 BLUF+EAL 1067 Escherichia coli H397 P(γ) H1EL63 NP_415681.1 403 BLUF+EAL 1068 Escherichia coli H489 P(γ) E9XXX0 YP_002998973.1 403 BLUF+EAL 1069 Escherichia coli H494 P(γ) H1F5D1 NP_415681.1 403 BLUF+EAL 1070 Escherichia coli H591 P(γ) F4VDH0 NP_415681.1 403 BLUF+EAL 1071 Escherichia coli H736 P(γ) F4SGE2 NP_415681.1 403 BLUF+EAL 1072 Escherichia coli HVH 24 (4-5985145) P(γ) T5U3L7 EQN85704.1/YP_002328824.1 403 BLUF+EAL 1073 Escherichia coli HVH 87 (4-5977630) P(γ) T6LQJ1 WP_021526772.1 403 BLUF+EAL 1074

A55

Escherichia coli IAI1 P(γ) B7LX75 NP_415681.1 403 BLUF+ EAL 1075 Escherichia coli IAI39 P(γ) B7NJI1 YP_001744038.1 403 BLUF+ EAL 1076 Escherichia coli J53 P(γ) I0ZQT4 EIE36605.1/YP_002292481.1 429 BLUF+EAL 1077 Escherichia coli JJ1886 P(γ) YP_008721327.1 403 BLUF+EAL 1078 Escherichia coli KTE104 P(γ) L3B881 ELI09680.1/WP_001535319.1 403 BLUF+EAL 1079 Escherichia coli KTE143 P(γ) L3VHA7 ELF21054.1/WP_001330601.1 403 BLUF+EAL 1080 Escherichia coli KTE147 P(γ) L4J3Y8 WP_001469311.1 403 BLUF+EAL 1081 Escherichia coli KTE189 P(γ) L4U2B8 WP_001535319.1 403 BLUF+EAL 1082 Escherichia coli KTE24 P(γ) S0WSF1 WP_016234228.1 203 Short-BLUF 1083 Escherichia coli KTE36 P(γ) S0Y267 WP_001330601.1/EOU92452.1 403 BLUF+EAL 1084 Escherichia coli KTE37 P(γ) S0Y3B4 WP_001330601.1/EOU92469.1 403 BLUF+EAL 1085 Escherichia coli KTE38 P(γ) S0Z706 WP_001330601.1/EOV06473.1 403 BLUF+EAL 1086 Escherichia coli KTE69 P(γ) S1E0R2 WP_001330601.1/EOV65043.1 403 BLUF+EAL 1087 Escherichia coli KTE70 P(γ) S1EQY3 WP_001330601.1/EOV73843.1 403 BLUF+EAL 1088 Escherichia coli KTE74 P(γ) S1GJK9 WP_001330601.1/EOV95898.1 403 BLUF+EAL 1089 Escherichia coli KTE75 P(γ) L3QAD1 WP_001563125.1 403 BLUF+EAL 1090 Escherichia coli KTE98 P(γ) S1GV17 EOV99135.1/WP_001330601.1 403 BLUF+EAL 1091 Escherichia coli M605 P(γ) F4SXD2 NP_415681.1 403 BLUF+EAL 1092 Escherichia coli M718 P(γ) F4TD47 NP_415681.1 403 BLUF+EAL 1093 Escherichia coli M863 P(γ) E9YT62 NP_415681.1 403 BLUF+EAL 1094 Escherichia coli MS 107-1 P(γ) D8ELF2 NP_415681.1 403 BLUF+EAL 1095 Escherichia coli MS 110-3 P(γ) E5ZQR8 NP_415681.1 403 BLUF+EAL 1096 Escherichia coli MS 115-1 P(γ) D7Y2E5 NP_415681.1 403 BLUF+EAL 1097 Escherichia coli MS 116-1 P(γ) D8AP06 NP_415681.1 403 BLUF+EAL 1098 Escherichia coli MS 117-3 P(γ) E9TJ35 NP_415681.1 403 BLUF+EAL 1099 Escherichia coli MS 119-7 P(γ) D8E362 NP_415681.1 403 BLUF+EAL 1100 Escherichia coli MS 124-1 P(γ) E1JCK6 NP_415681.1 403 BLUF+EAL 1101 Escherichia coli MS 145-7 P(γ) E1IU70 NP_415681.1 403 BLUF+EAL 1102 Escherichia coli MS 146-1 P(γ) E1HU81 WP_000958299.1 184 Short-BLUF 1103 Escherichia coli MS 153-1 P(γ) E6AF94 NP_415681.1 403 BLUF+EAL 1104 Escherichia coli MS 16-3 P(γ) E6AUN3 NP_415681.1 403 BLUF+EAL 1105 Escherichia coli MS 175-1 P(γ) D8B0N6 NP_415681.1 403 BLUF+EAL 1106 Escherichia coli MS 182-1 P(γ) D7YEE0 NP_415681.1 403 BLUF+EAL 1107 Escherichia coli MS 185-1 P(γ) D8C9B8 NP_415681.1 403 BLUF+EAL 1108 Escherichia coli MS 187-1 P(γ) D7ZPK1 NP_415681.1 403 BLUF+EAL 1109 Escherichia coli MS 196-1 P(γ) D8C5N7 NP_415681.1 403 BLUF+EAL 1110 Escherichia coli MS 198-1 P(γ) D7X3D5 NP_415681.1 403 BLUF+EAL 1111 Escherichia coli MS 200-1 P(γ) D8BP86 NP_415681.1 403 BLUF+EAL 1112 Escherichia coli MS 21-1 P(γ) D8AF51 WP_001330601.1 403 BLUF+EAL 1113 Escherichia coli MS 45-1 P(γ) D7YSY1 NP_415681.1 403 BLUF+EAL 1114 Escherichia coli MS 57-2 P(γ) E9UH50 NP_415681.1 403 BLUF+EAL 1115 Escherichia coli MS 60-1 P(γ) E9TPH6 NP_415681.1 403 BLUF+EAL 1116 Escherichia coli MS 69-1 P(γ) D7ZI44 NP_415681.1 403 BLUF+EAL 1117 Escherichia coli MS 78-1 P(γ) E1I486 WP_001333133.1 381 BLUF+EAL 1118 Escherichia coli MS 79-10 P(γ) F8XHY8 NP_415681.1 403 BLUF+EAL 1119 Escherichia coli MS 84-1 P(γ) D7XUY0 NP_415681.1 403 BLUF+EAL 1120 Escherichia coli MS 85-1 P(γ) E6BLL3 NP_415681.1 403 BLUF+EAL 1121 Escherichia coli NC101 P(γ) E0QZI5 NP_415681.1 403 BLUF+EAL 1122 Escherichia coli O1:K1 / APEC P(γ) A1AA89 NP_415681.1 403 BLUF+ EAL 1123

A56

Escherichia coli O103:H2 (strain 12009 / EHEC) P(γ) C8U6S6 NP_415681.1 403 BLUF+ EAL 1124 Escherichia coli O104:H4 str. 01-09591 P(γ) F9CGF7 NP_415681.1 403 BLUF+EAL 1125 Escherichia coli O104:H4 str. 04-8351 P(γ) G5U6U7 NP_415681.1 403 BLUF+EAL 1126 Escherichia coli O104:H4 str. 09-7901 P(γ) G5TW99 NP_415681.1 403 BLUF+EAL 1127 Escherichia coli O104:H4 str. 11-3677 P(γ) G5UQE0 NP_415681.1 403 BLUF+EAL 1128 Escherichia coli O104:H4 str. 11-4404 P(γ) G5VMA5 NP_415681.1 403 BLUF+EAL 1129 Escherichia coli O104:H4 str. 11-4522 P(γ) G5W1R3 NP_415681.1 403 BLUF+EAL 1130 Escherichia coli O104:H4 str. 11-4623 P(γ) G5W4F4 NP_415681.1 403 BLUF+EAL 1131 Escherichia coli O104:H4 str. 11-4632 C1 P(γ) G5WRS9 NP_415681.1 403 BLUF+EAL 1132 Escherichia coli O104:H4 str. 11-4632 C2 P(γ) G5X6D7 NP_415681.1 403 BLUF+EAL 1133 Escherichia coli O104:H4 str. 11-4632 C3 P(γ) G5XQC8 NP_415681.1 403 BLUF+EAL 1134 Escherichia coli O104:H4 str. 11-4632 C4 P(γ) G5XVF0 NP_415681.1 403 BLUF+EAL 1135 Escherichia coli O104:H4 str. 11-4632 C5 P(γ) G5YFA6 NP_415681.1 403 BLUF+EAL 1136 Escherichia coli O104:H4 str. C227-11 P(γ) F9HVJ8 NP_415681.1 403 BLUF+EAL 1137 Escherichia coli O104:H4 str. C236-11 P(γ) G5TEW1 NP_415681.1 403 BLUF+EAL 1138 Escherichia coli O104:H4 str. LB226692 P(γ) F8YEL3 WP_001386733.1 372 BLUF+EAL 1139 Escherichia coli O111:H- (strain 11128 / EHEC) P(γ) C8UNS0 YP_003233971.1 403 BLUF+ EAL 1140 Escherichia coli O127:H6 (strain E2348/69 / EPEC) P(γ) B7UQ48 CAS08828.1/YP_002328824.1 403 BLUF+ EAL 1141 Escherichia coli O150:H5 (strain SE15) P(γ) D2NHM0 NP_753514.1 429 BLUF+ EAL 1142 Escherichia coli O157:H- str. 493-89 P(γ) E8HST2 EFX12369.1/YP_006158540.1 403 BLUF+EAL 1143 Escherichia coli O157:H- str. H 2687 P(γ) E8I6Q4 EFX16781.1/YP_006158540.1 403 BLUF+EAL 1144 Escherichia coli O157:H43 str. T22 P(γ) H4FLQ5 NP_415681.1 403 BLUF+EAL 1145 Escherichia coli O157:H7 str. G5101 P(γ) E8HDS1 NP_415681.1 403 BLUF+EAL 1146 Escherichia coli O157:H7 str. LSU-61 P(γ) E8JDA4 EFX31706.1/YP_006158540.1 403 BLUF+EAL 1147 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) P(γ) B7N3W4 NP_415681.1 403 BLUF+ EAL 1148 Escherichia coli O18:K1:H7 (strain IHE3034 / ExPEC) P(γ) D5D0X4 NP_415681.1 403 BLUF+ EAL 1149 Escherichia coli O25b:H4-ST131 str. EC958 P(γ) N1N5N1 WP_001295983.1 146 Short-BLUF 1150 Escherichia coli O26:H11 (strain 11368 / EHEC) P(γ) C8TQH3 NP_415681.1 403 BLUF+ EAL 1151 Escherichia coli O44:H18 (strain 042 / EAEC) P(γ) D3H1V7 NP_753514.1 429 BLUF+ EAL 1152 Escherichia coli O55:H7 str. 3256-97 P(γ) E8IK46 WP_000958309.1 106 Short-BLUF 1153 Escherichia coli O55:H7 str. RM12579 P(γ) H6MEI0 AEZ39985.1/YP_006158540.1 403 BLUF+EAL 1154 Escherichia coli O55:H7 str. USDA 5905 P(γ) E8IY83 EFX26987.1/YP_006158540.1 403 BLUF+EAL 1155 Escherichia coli O6 P(γ) Q8FI42 NP_753514.1 429 BLUF+ EAL 1156 Escherichia coli O6:K15:H31 536 / UPEC) P(γ) Q0TIL8 NP_415681.1 403 BLUF+ EAL 1157 Escherichia coli O83:H1 (strain NRG 857C / AIEC) P(γ) E4P2E2 ADR26615.1/YP_006119549.1 403 BLUF+EAL 1158 Escherichia coli O9:H4 / HS P(γ) A7ZZ94 NP_415681.1 403 BLUF+ EAL 1159 Escherichia coli OK1180 P(γ) E7IPF0 NP_415681.1 403 BLUF+EAL 1160 Escherichia coli OK1357 P(γ) E7J2J6 NP_415681.1 403 BLUF+EAL 1161 Escherichia coli OR:K5:H- (strain ABU 83972) P(γ) E1PJK6 NP_753514.1 429 BLUF+EAL 1162 Escherichia coli P0301867.11 P(γ) N3F7P9 WP_001484419.1 403 BLUF+EAL 1163 Escherichia coli P0304816.15 P(γ) N4BKD7 ENF50218.1/WP_001620704.1 373 BLUF+EAL 1164 Escherichia coli P0305260.5 P(γ) N4GMJ1 WP_001648704.1 403 BLUF+EAL 1165 Escherichia coli PCN033 P(γ) F7MVM7 NP_415681.1 403 BLUF+EAL 1166 Escherichia coli RN587/1 P(γ) E7JQF9 EFZ72697.1/YP_002328824.1 403 BLUF+EAL 1167 Escherichia coli S88 P(γ) B7MK58 NP_415681.1 403 BLUF+ EAL 1168 Escherichia coli SCI-07 P(γ) H8D7Y9 NP_415681.1 403 BLUF+EAL 1169 Escherichia coli SE11 P(γ) B6I9L9 BAG76730.1/YP_002292481.1 429 BLUF+ EAL 1170 Escherichia coli SE15 P(γ) YP_003349094.1 429 BLUF+EAL 1171 Escherichia coli SMS-3-5 / SECEC P(γ) B1LI04 YP_001744038.1 403 BLUF+ EAL 1172

A57

Escherichia coli STEC_7v P(γ) F3LXX7 WP_001360582.1 372 BLUF+EAL 1173 Escherichia coli STEC_94C P(γ) G1ZY43 WP_001378868.1 261 Short-BLUF 1174 Escherichia coli STEC_B2F1 P(γ) G1Y830 WP_000958302.1 371 BLUF+EAL 1175 Escherichia coli STEC_C165-02 P(γ) G1YNH8 WP_001376825.1 372 BLUF+EAL 1176 Escherichia coli STEC_DG131-3 P(γ) G2AEF4 WP_001379733.1 372 BLUF+EAL 1177 Escherichia coli STEC_EH250 P(γ) G2ATD7 WP_001379733.1 372 BLUF+EAL 1178 Escherichia coli STEC_H.1.8 P(γ) G2BMD5 WP_001382007.1 230 Short-BLUF 1179 Escherichia coli STEC_MHI813 P(γ) G2C2Z3 WP_001383099.1 372 BLUF+EAL 1180 Escherichia coli STEC_S1191 P(γ) G2CJ51 NP_415681.1 403 BLUF+EAL 1181 Escherichia coli TA124 P(γ) H1FGR3 WP_001389598.1 403 BLUF+EAL 1182 Escherichia coli TA143 P(γ) F4U625 NP_415681.1 403 BLUF+EAL 1183 Escherichia coli TA206 P(γ) F4TT04 WP_000958310.1 176 Short-BLUF 1184 Escherichia coli TA271 P(γ) F4ULK8 NP_415681.1 403 BLUF+EAL 1185 Escherichia coli TW10509 P(γ) E9XMH9 WP_000958307.1 403 BLUF+EAL 1186 Escherichia coli TX1999 P(γ) G2CYS1 NP_415681.1 403 BLUF+EAL 1187 Escherichia coli UMN026 P(γ) YP_002412195.1 403 BLUF+EAL 1188 Escherichia coli UMNF18 P(γ) G0FBW4 NP_415681.1 403 BLUF+EAL 1189 Escherichia coli UMNK88 P(γ) F4M2X4 NP_415681.1 403 BLUF+EAL 1190 Escherichia coli WV_060327 P(γ) E7U6E5 NP_415681.1 403 BLUF+EAL 1191 Escherichia coli XH001 P(γ) G2F1Z8 NP_415681.1 403 BLUF+EAL 1192 Escherichia coli XH140A P(γ) F9QYE5 NP_415681.1 BLUF+EAL 1193 250 Escherichia hermannii NBRC 105704 P(γ) H5V3N0 WP_002436603.1 BLUF+EAL 1194 H5UZV4 WP_002434328.1 406 BLUF+EAL 1195 251 Escherichia sp. 3_2_53FAA P(γ) C1HJN0 NP_753514.1 429 BLUF+ EAL 1196 252 Frateuria aurantia ATCC 33424 P(γ) H8L2L8 YP_005377167.1 424 BLUF+EAL 1197 H8L2L7 YP_005377166.1 439 BLUF+EAL 1198 253 gamma proteobacterium BDW918 P(γ) I2JPC2 WP_008246638.1 138 Short-BLUF 1199 254 gamma proteobacterium HIMB55 P(γ)U H3NRI2 WP_009470377.1 146 Short-BLUF 1200 255 gamma proteobacterium IMCC1989 P(γ) F3LF24 WP_009669485.1 144 Short-BLUF 1201 256 gamma proteobacterium IMCC2047 P(γ)U F3KDB1 WP_008530288.1 150 Short-BLUF 1202 257 gamma proteobacterium IMCC2047 P(γ)Unc EGG99643.1 150 Short-BLUF 1203 258 gamma proteobacterium IMCC3088 P(γ)U F3KYX3 WP_009574606.1 145 Short-BLUF 1204 259 gamma proteobacterium NOR5-3 P(γ)U B8KEY4 WP_009021778.1 161 Short-BLUF 1205 260 gamma proteobacterium NOR5-3 P(γ)U B8KLI1 WP_009023838.1 157 Short-BLUF 1206 261 gamma proteobacterium NOR5-3 P(γ)U B8KT47 WP_009021276.1 149 Short-BLUF 1207 262 gamma proteobacterium WG36 P(γ) WP_017494424.1 405 BLUF+EAL 1208 263 Gayadomonas joobiniege P(γ) WP_017445646.1 152 Short-BLUF 1209 264 Gilvimarinus chinensis P(γ) WP_020208650.1 152 Short-BLUF 1210 265 Glaciecola arctica BSs20135 P(γ) K6Y178 WP_007616696.1 136 Short-BLUF 1211 K6Y8U9 WP_007622166.1 134 Short-BLUF 1212 266 Glaciecola mesophila KMM 241 P(γ) K6XXC1 WP_006993405.1 133 Short-BLUF 1213 267 Glaciecola nitratireducens JCM 12485 P(γ) G4QF34 YP_004870371.1 147 Short-BLUF 1214 268 Grimontia hollisae CIP 101886 P(γ) D0IB49 WP_005505863.1 136 Short-BLUF 1215 269 Grimontia sp. AK16 P(γ) R1IQH4 WP_002541795.1 136 Short-BLUF 1216 270 Halothiobacillus neapolitanus c2 P(γ) D0L046 YP_003263116.1 143 Short-BLUF 1217 271 Kangiella aquimarina P(γ) WP_018624129.1 143 Short-BLUF 1218 272 Kangiella koreensis DSM 16069 P(γ) C7R790 YP_003147314.1 143 Short-BLUF 1219 273 Klebsiella oxytoca P(γ) WP_016810135.1 407 BLUF+EAL 1220 Klebsiella oxytoca P(γ) WP_023320606.1 407 BLUF+EAL 1221

A58

Klebsiella oxytoca P(γ) WP_017145797.1 409 BLUF+EAL 1222 Klebsiella oxytoca P(γ) WP_016808785.1 409 BLUF+EAL 1223 Klebsiella oxytoca 10-5242 P(γ) H3L520 EHT02598.1/WP_004849017.1 407 BLUF+EAL 1224 P(γ) H3L8A3 EHS99926.1/WP_004851219.1 408 BLUF+EAL 1225 Klebsiella oxytoca 10-5243 P(γ) H3LKF5 WP_004100387.1 407 BLUF+EAL 1226 P(γ) H3LPD4 WP_004102968.1 390 BLUF+EAL 1227 P(γ) H3LNU7 EHS97649.1/WP_004102385.1 409 BLUF+EAL 1228 Klebsiella oxytoca 10-5245 P(γ) H3M2I6 WP_004111512.1 407 BLUF+EAL 1229 Klebsiella oxytoca 10-5245 P(γ) H3M586 EHS97119.1/WP_004113307.1 409 BLUF+EAL 1230 Klebsiella oxytoca 10-5250 P(γ) H3N9V3 WP_004130625.1 407 BLUF+EAL 1231 P(γ) H3MWL6 EHT14305.1/WP_004119787.1 408 BLUF+EAL 1232 Klebsiella oxytoca ATCC 8724 P(γ) G8WFT1 YP_005018934.1 407 BLUF+EAL 1233 P(γ) G8WGX1 AEX05998.1/YP_005020237.1 402 BLUF+EAL 1234 Klebsiella oxytoca E718 P(γ) I6W3I1 YP_006497531.1 407 BLUF+EAL 1235 Klebsiella oxytoca M5al P(γ) K6JLZ8 WP_004134964.1 407 BLUF+EAL 1236 Klebsiella oxytoca M5al P(γ) K6JK93 WP_004136285.1 405 BLUF+EAL 1237 274 Klebsiella pneumoniae P(γ) R4YC97 CCI78036.1 403 BLUF+EAL 1238 Klebsiella pneumoniae P(γ) G0GUP8 YP_005953822.1 403 BLUF+EAL 1239 Klebsiella pneumoniae P(γ) G0GPP1 YP_005954630.1 405 BLUF+EAL 1240 Klebsiella pneumoniae P(γ) WP_017899618.1 403 BLUF+EAL 1241 Klebsiella pneumoniae P(γ) WP_021314053.1 403 BLUF+EAL 1242 Klebsiella pneumoniae P(γ) WP_020802923.1 405 BLUF+EAL 1243 Klebsiella pneumoniae P(γ) WP_017879970.1 405 BLUF+EAL 1244 Klebsiella pneumoniae P(γ) WP_021314208.1 405 BLUF+EAL 1245 Klebsiella pneumoniae P(γ) WP_017900341.1 405 BLUF+EAL 1246 Klebsiella pneumoniae P(γ) WP_023288895.1 403 BLUF+EAL 1247 Klebsiella pneumoniae P(γ) WP_023287389.1 403 BLUF+EAL 1248 Klebsiella pneumoniae P(γ) WP_023302151.1 403 BLUF+EAL 1249 Klebsiella pneumoniae P(γ) WP_023283451.1 410 BLUF+EAL 1250 Klebsiella pneumoniae P(γ) WP_023297241.1 403 BLUF+EAL 1251 Klebsiella pneumoniae P(γ) WP_023342830.1 405 BLUF+EAL 1252 Klebsiella pneumoniae P(γ) WP_023341511.1 405 BLUF+EAL 1253 Klebsiella pneumoniae P(γ) WP_023327961.1 405 BLUF+EAL 1254 Klebsiella pneumoniae P(γ) WP_023322569.1 405 BLUF+EAL 1255 Klebsiella pneumoniae P(γ) WP_023316827.1 405 BLUF+EAL 1256 Klebsiella pneumoniae P(γ) WP_023301958.1 405 BLUF+EAL 1257 Klebsiella pneumoniae P(γ) WP_023286396.1 405 BLUF+EAL 1258 Klebsiella pneumoniae P(γ) WP_023318182.1 405 BLUF+EAL 1259 Klebsiella pneumoniae P(γ) WP_023340100.1 405 BLUF+EAL 1260 Klebsiella pneumoniae 342 P(γ) B5XQZ5 YP_002238639.1 405 BLUF+ EAL 1261 P(γ) B5XZ96 ACI08361.1/YP_002239613.1 403 BLUF+ EAL 1262 Klebsiella pneumoniae 700603 P(γ) M7PV04 WP_004886055.1 403 BLUF+EAL 1263 Klebsiella pneumoniae 700603 P(γ) M7PCJ7 WP_004206010.1 405 BLUF+EAL 1264 Klebsiella pneumoniae ATCC BAA-1705 P(γ) M7QLZ6 EMR23689.1/YP_005226813.1 405 BLUF+EAL 1265 Klebsiella pneumoniae ATCC BAA-2146 P(γ) M7QLK1 EMR23559.1/YP_005226813.1 405 BLUF+EAL 1266 Klebsiella pneumoniae CG43 P(γ) YP_008659363.1 403 BLUF+EAL 1267 Klebsiella pneumoniae DMC0799 P(γ) S7BC21 EPO21704.1/YP_001334448.1 403 BLUF+EAL 1268 Klebsiella pneumoniae hvKP1 P(γ) M2AJV2 EMB10239.1/YP_001334448.1 403 BLUF+EAL 1269 Klebsiella pneumoniae hvKP1 P(γ) M2ATT4 EMB12948.1/YP_001335259.1 405 BLUF+EAL 1270

A59

Klebsiella pneumoniae JHCK1 P(γ) M3V4M6 YP_001334448.1 403 BLUF+EAL 1271 Klebsiella pneumoniae JHCK1 P(γ) M3SU26 EMH92743.1/YP_001335259.1 405 BLUF+EAL 1272 Klebsiella pneumoniae KP-11 P(γ) S2CCS2 EOZ72815.1/YP_001334448.1 403 BLUF+EAL 1273 Klebsiella pneumoniae KP-7 P(γ) S1TBD0 EOY66353.1/YP_001334448.1 403 BLUF+EAL 1274 Klebsiella pneumoniae NTUH-K2044 P(γ) C4X832 YP_002919357.1 422 BLUF+ EAL 1275 P(γ) C4X5Q9 YP_002918534.1 403 BLUF+ EAL 1276 Klebsiella pneumoniae RYC492 P(γ) M5QAQ1 WP_004893335.1 403 BLUF+EAL 1277 Klebsiella pneumoniae RYC492 P(γ) M5Q7X9 EMH98112.1/YP_006636433.1 405 BLUF+EAL 1278 275 Klebsiella pneumoniae subsp. pneumoniae 1084 P(γ) K4HAP6 YP_006637253.1/YP_001334448.1 403 BLUF+EAL 1279 Klebsiella pneumoniae subsp. pneumoniae 1084 P(γ) K4H3X6 YP_006636433.1 405 BLUF+EAL 1280 Klebsiella pneumoniae subsp. pneumoniae ATCC 700721 P(γ) A6T8V8 ABR77029.1/YP_001335259.1 405 BLUF+ EAL 1281 Klebsiella pneumoniae subsp. pneumoniae ATCC 700721 P(γ) A6T6J7 ABR76218.1/YP_001334448.1 403 BLUF+ EAL 1282 Klebsiella pneumoniae subsp. pneumoniae DSM 30104 P(γ) J2X7Q0 EJK91023.1/YP_001335259.1 405 BLUF+EAL 1283 Klebsiella pneumoniae subsp. pneumoniae Ecl8 P(γ) K4UDV3 CCN29648.1/YP_001335259.1 405 BLUF+EAL 1284 Klebsiella pneumoniae subsp. pneumoniae HS11286 P(γ) G8W5H8 YP_005225909.1 403 BLUF+EAL 1285 Klebsiella pneumoniae subsp. pneumoniae HS11286 P(γ) G8W1U2 AEW61211.1/YP_005226813.1 405 BLUF+EAL 1286 Klebsiella pneumoniae subsp. pneumoniae KpMDU1 P(γ) N9UNX0 WP_002895176.1 103 Short-BLUF 1287 Klebsiella pneumoniae subsp. pneumoniae KpMDU1 P(γ) N9UB22 ENY57642.1/YP_005226813.1 405 BLUF+EAL 1288 Klebsiella pneumoniae subsp. pneumoniae KPNIH1 P(γ) J2LLB7 EJJ33749.1/YP_005226813.1 405 BLUF+EAL 1289 Klebsiella pneumoniae subsp. pneumoniae KPNIH10 P(γ) J2Q500 EJJ73872.1/YP_005226813.1 405 BLUF+EAL 1290 Klebsiella pneumoniae subsp. pneumoniae KPNIH11 P(γ) J1Y1B0 EJJ83951.1/YP_005226813.1 405 BLUF+EAL 1291 Klebsiella pneumoniae subsp. pneumoniae KPNIH12 P(γ) J2R422 EJJ85679.1/YP_005226813.1 405 BLUF+EAL 1292 Klebsiella pneumoniae subsp. pneumoniae KPNIH14 P(γ) J1XPZ0 EJJ86178.1/YP_005226813.1 405 BLUF+EAL 1293 Klebsiella pneumoniae subsp. pneumoniae KPNIH16 P(γ) J2SEY9 EJK01005.1/YP_005226813.1 405 BLUF+EAL 1294 Klebsiella pneumoniae subsp. pneumoniae KPNIH17 P(γ) J1ZJT8 EJK00872.1/YP_005226813.1 405 BLUF+EAL 1295 Klebsiella pneumoniae subsp. pneumoniae KPNIH18 P(γ) J1ZTT7 EJK09919.1/YP_005226813.1 405 BLUF+EAL 1296 Klebsiella pneumoniae subsp. pneumoniae KPNIH19 P(γ) J2TV30 EJK17135.1/YP_005226813.1 405 BLUF+EAL 1297 Klebsiella pneumoniae subsp. pneumoniae KPNIH2 P(γ) J2BEA0 EJJ34470.1/YP_005226813.1 405 BLUF+EAL 1298 Klebsiella pneumoniae subsp. pneumoniae KPNIH20 P(γ) J2TVY5 EJK17435.1/YP_005226813.1 405 BLUF+EAL 1299 Klebsiella pneumoniae subsp. pneumoniae KPNIH21 P(γ) J2JB02 EJK27376.1/YP_005226813.1 405 BLUF+EAL 1300 Klebsiella pneumoniae subsp. pneumoniae KPNIH22 P(γ) J2VAC5 EJK33703.1/YP_005226813.1 405 BLUF+EAL 1301 Klebsiella pneumoniae subsp. pneumoniae KPNIH23 P(γ) J2BVP2 EJK34244.1/YP_005226813.1 405 BLUF+EAL 1302 Klebsiella pneumoniae subsp. pneumoniae KPNIH4 P(γ) J2CGH8 EJJ47550.1/YP_005226813.1 405 BLUF+EAL 1303 Klebsiella pneumoniae subsp. pneumoniae KPNIH5 P(γ) J1V7T6 EJJ51671.1/YP_005226813.1 405 BLUF+EAL 1304 Klebsiella pneumoniae subsp. pneumoniae KPNIH6 P(γ) J1VSE1 EJJ58196.1/YP_005226813.1 405 BLUF+EAL 1305 Klebsiella pneumoniae subsp. pneumoniae KPNIH7 P(γ) J1VSD5 EJJ63833.1/YP_005226813.1 405 BLUF+EAL 1306 Klebsiella pneumoniae subsp. pneumoniae KPNIH8 P(γ) J1WBB9 EJJ70043.1/YP_005226813.1 405 BLUF+EAL 1307 Klebsiella pneumoniae subsp. pneumoniae KPNIH9 P(γ) J1WDS7 EJJ70888.1/YP_005226813.1 405 BLUF+EAL 1308 Klebsiella pneumoniae subsp. pneumoniae KpQ3 P(γ) M5GMC5 EKF78982.1/YP_001335259.1 405 BLUF+EAL 1309 Klebsiella pneumoniae subsp. pneumoniae ST258-K26BO P(γ) K4RS57 CCM80630.1/YP_005226813.1 405 BLUF+EAL 1310 Klebsiella pneumoniae subsp. pneumoniae ST258-K28BO P(γ) K4SA97 CCM86960.1/YP_005226813.1 405 BLUF+EAL 1311 Klebsiella pneumoniae subsp. pneumoniae ST512-K30BO P(γ) K4SX07 CCM95184.1/YP_005226813.1 405 BLUF+EAL 1312 Klebsiella pneumoniae subsp. pneumoniae WGLW1 P(γ) K1NF33 EKB66739.1/YP_001334448.1 403 BLUF+EAL 1313 K1M9Z4 EKB66010.1/YP_001335259.1 405 BLUF+EAL 1314 Klebsiella pneumoniae subsp. pneumoniae WGLW2 P(γ) K1NR75 EKB79227.1/YP_001334448.1 403 BLUF+EAL 1315 K1N312 EKB75950.1/YP_001335259.1 405 BLUF+EAL 1316 Klebsiella pneumoniae subsp. pneumoniae WGLW3 P(γ) K1N1S9 YP_001334448.1/EKB75485.1 403 BLUF+EAL 1317 K1NLB8 EKB77327.1/YP_001335259.1 405 BLUF+EAL 1318 Klebsiella pneumoniae subsp. pneumoniae WGLW5 P(γ) K1Q3I3 EKB86354.1/YP_001334448.1 403 BLUF+EAL 1319

A60

K1Q1K2 WP_004184418.1 390 BLUF+EAL 1320 K1P7W3 EKB85222.1/YP_001335259.1 405 BLUF+EAL 1321 276 Klebsiella pneumoniae subsp. rhinoscleromatis ATCC 13884 P(γ) C8TA32 EEW39489.1/YP_001335259.1 405 BLUF+ EAL 1322 P(γ) C8T1B3 WP_004142148.1 405 BLUF+ EAL 1323 Klebsiella pneumoniae UHKPC179 P(γ) S7FYI3 YP_001334448.1 403 BLUF+EAL 1324 Klebsiella pneumoniae UHKPC23 P(γ) R9BEZ7 EOR15588.1/YP_005226813.1 405 BLUF+EAL 1325 Klebsiella pneumoniae UHKPC57 P(γ) S2EQN8 EPA91839.1/YP_001334448.1 403 BLUF+EAL 1326 Klebsiella pneumoniae UHKPC81 P(γ) S1UVJ0 EOY85408.1/YP_001334448.1 403 BLUF+EAL 1327 Klebsiella pneumoniae VA360 P(γ) M5SGV5 EMI36105.1/YP_005226813.1 405 BLUF+EAL 1328 277 Klebsiella sp. 1_1_55 P(γ) D6GDL7 EFD87032.1/WP_008804990.1 405 BLUF+ EAL 1329 D6GGM4 WP_008805714.1 403 BLUF+ EAL 1330 Klebsiella sp. 4_1_44FAA P(γ) G9RCF4 EHL93455.1/YP_001334448.1 403 BLUF+EAL 1331 Klebsiella sp. KTE92 P(γ) R8XC78 EOQ54795.1/YP_002239613.1 403 BLUF+EAL 1332 Klebsiella sp. KTE92 P(γ) R8XFY6 WP_016160979.1 405 BLUF+EAL 1333 Klebsiella sp. MS 92-3 P(γ) F3Q8C8 EGF62238.1/YP_001335259.1 405 BLUF+EAL 1334 F3PZ97 EGF65408.1/YP_001334448.1 403 BLUF+EAL 1335 Klebsiella sp. OBRC7 P(γ) J5V6R0 WP_004849017.1 407 BLUF+EAL 1336 278 Klebsiella variicola (strain At-22) P(γ) D3RGS1 YP_003439664.1 405 BLUF+ EAL 1337 D3RM34 YP_003440514.1 403 BLUF+ EAL 1338 Klebsiella variicola CAG:634 P(γ) R5WD52 CDA00595.1/YP_002239613.1 403 BLUF+EAL 1339 R5WE11 WP_008804990.1 405 BLUF+EAL 1340 R5X5Z9 WP_022066376.1 390 BLUF+EAL 1341 279 Lamprocystis purpurea P(γ) WP_020505137.1 295 BLUF+PsiE 1342 280 Legionella drancourtii LLAP12 P(γ) G9ETS2 WP_006872576.1 155 Short-BLUF 1343 281 Legionella longbeachae D-4968 P(γ) D1RLZ8 WP_003636764.1 309 BLUF+PAS 1344 282 Legionella longbeachae serogroup 1 (strain NSW150) P(γ) D3HJ09 YP_003455474.1 708 BLUF+3PAS+GGDEF 1345 283 Leucothrix mucor P(γ) WP_022951283.1 139 Short-BLUF 1346 WP_022951988.1 143 Short-BLUF 1347 284 Marichromatium purpuratum 984 P(γ) F9TWL2 WP_005220255.1 1221 2PAS+GGDEF+EAL+BLUF 1348 F9TYC6 WP_005221896.1 137 Short-BLUF 1349 285 marine gamma proteobacterium HTCC2080 P(γ)U A0Z2D8 WP_007233984.1 150 Short-BLUF 1350 A0Z4F4 WP_007234700.1 159 Short-BLUF 1351 A0Z3A0 WP_007234296.1 152 Short-BLUF 1352 286 marine gamma proteobacterium HTCC2148 P(γ)U B7S2E6 WP_007230530.1 127 Short-BLUF 1353 287 Marinobacter adhaerens (strain HP15) P(γ) E4PFT3 YP_005885931.1 143 Short-BLUF 1354 E4PIQ9 185 Short-BLUF 1355 288 Marinobacter algicola DG893 P(γ) A6F2F1 WP_007154440.1 188 Short-BLUF 1356 289 Marinobacter aquaeolei VT8 P(γ) A1U4G7 YP_960073.1 189 Short-BLUF 1357 290 Marinobacter hydrocarbonoclasticus ATCC 49840 P(γ) H8WBH9 YP_005430586.1 189 Short-BLUF 1358 291 Marinobacter lipolyticus SM19 P(γ) R8B0A9 WP_012138058.1 151 Short-BLUF 1359 292 Marinobacter manganoxydans MnI7-9 P(γ) G6YW66 WP_008175045.1 143 Short-BLUF 1360 G6YUG7 WP_008174059.1 188 Short-BLUF 1361 293 Marinomonas mediterranea ATCC 700492 P(γ) F2JZB3 YP_004315034.1 138 Short-BLUF 1362 F2JWR3 YP_004313663.1 144 Short-BLUF 1363 294 Marinomonas posidonica CECT 7376 P(γ) F6CVF9 YP_004482255.1 143 Short-BLUF 1364 295 Marinomonas sp. MED121 P(γ) A3YED7 WP_009835955.1 140 Short-BLUF 1365 A3YFN4 WP_009833224.1 152 Short-BLUF 1366 A3YFL0 WP_009833248.1 154 Short-BLUF 1367 Marinomonas sp. MWYL1 P(γ) A6VYY7 YP_001341601.1 142 Short-BLUF 1368

A61

296 Methylobacter marinus P(γ) WP_020161578.1 289 BLUF+PsiE 1369 297 Methylobacter tundripaludum SV96 P(γ) G3ISM9 WP_006890370.1 289 Short-BLUF 1370 298 Methylohalobius crimeensis P(γ) WP_022950030.1 290 BLUF+PsiE 1371 299 Methylomicrobium alcaliphilum DSM 19304 P(γ) G4T071 YP_004916955.1 136 Short-BLUF 1372 G4T077 YP_004916961.1 294 Short-BLUF 1373 G4T0S3 YP_004915950.1 141 Short-BLUF 1374 G4T2T3 YP_004916161.1 1111 PAS+GGDEF+EAL+BLUF 1375 300 Methylomicrobium buryatense P(γ) WP_017838976.1 294 BLUF+PsiE 1376 WP_017840127.1 1097 LeuBD+PAS+GGDEF+EAL+BLUF 1377 WP_017840877.1 141 Short-BLUF 1378 WP_017840373.1 141 Short-BLUF 1379 WP_017838971.1 136 Short-BLUF 1380 301 Methylomicrobium japanense P(γ) Q25BV7 BAE86881.1 141 Short-BLUF 1381 302 Methylomonas methanica (strain MC09) P(γ) G0A610 YP_004512959.1 120 Short-BLUF 1382 G0A1P9 YP_004512609.1 292 Short-BLUF 1383 G0A2A9 YP_004511421.1 1104 PAS+GGDEF+EAL+BLUF 1384 303 Methylophaga aminisulfidivorans MP P(γ) F5T211 WP_007146401.1 140 Short-BLUF 1385 304 Methylophaga lonarensis MPL P(γ) M7PJN9 WP_009725326.1 159 Short-BLUF 1386 305 Methylophaga thiooxidans DMS010 P(γ) C0N5Z8 WP_008291053.1 139 Short-BLUF 1387 C0N9F9 WP_008292188.1 136 Short-BLUF 1388 306 Neptuniibacter caesariensis P(γ) Q2BIC6 WP_007020013.1 142 Short-BLUF 1389 Q2BP57 WP_007020760.1 147 Short-BLUF 1390 307 Nevskia ramosa P(γ) WP_022977191.1 429 BLUF+SCHICH 1391 308 Pantoea agglomerans P(γ) WP_022625735.1 403 BLUF+EAL 1392 WP_010671955.1 395 BLUF+EAL 1393 WP_010670046.1 403 BLUF+EAL 1394 WP_022624234.1 395 BLUF+EAL 1395 Pantoea agglomerans 299R P(γ) L7BXC6 ELP25506.1/WP_003850648.1 395 BLUF+EAL 1396 L7BW56 ELP25775.1/WP_003850263.1 403 BLUF+EAL 1397 309 Pantoea ananatis P(γ) WP_019105298.1 415 BLUF+EAL 1398 Pantoea ananatis (strain AJ13355) P(γ) F2ET35 YP_005195892.1 403 BLUF+EAL 1399 F2EZT9 YP_003522512.1 397 BLUF+EAL 1400 Pantoea ananatis (strain LMG 20103) P(γ) D4GGD1 CP001875.2/YP_003522512.1 397 BLUF+ EAL 1401 D4GDM8 YP_003520043.1 403 BLUF+ EAL 1402 Pantoea ananatis LMG 5342 P(γ) G9AT61 CCF09855.1/YP_005195892.1 403 BLUF+EAL 1403 G9AXC0 YP_005197808.1 397 BLUF+EAL 1404 Pantoea ananatis PA13 P(γ) G7UHX4 YP_005993091.1/YP_005195892.1 403 BLUF+EAL 1405 G7UM94 YP_005990549.1 397 BLUF+EAL 1406 310 Pantoea dispersa EGD-AAK13 P(γ) U1TTN2 WP_021509874.1 403 BLUF+EAL 1407 311 Pantoea sp. aB P(γ) E0M383 WP_008926784.1 405 BLUF+EAL 1408 E0M391 ELP25506.1/WP_003850648.1 395 BLUF+EAL 1409 E0M088 EFM19210.1/WP_003850263.1 403 BLUF+EAL 1410 Pantoea sp. AS-PWVM4 P(γ) U2M401 WP_021182872.1 403 BLUF+EAL 1411 Pantoea sp. At-9b P(γ) E6WL97 YP_004118738.1 386 BLUF+EAL 1412 E6WBK2 YP_004116243.1 403 BLUF+EAL 1413 Pantoea sp. GM01 P(γ) J2LHM1 WP_007891430.1 403 BLUF+EAL 1414 Pantoea sp. Sc1 P(γ) H8DUK7 WP_009093254.1 395 BLUF+EAL 1415 H8DLJ6 WP_009090445.1 403 BLUF+EAL 1416 H8DUL4 WP_009093262.1 405 BLUF+EAL 1417

A62

Pantoea sp. SL1_M5 P(γ) WP_010256946.1 395 BLUF+EAL 1418 WP_010245539.1 403 BLUF+EAL 1419 Pantoea sp. YR343 P(γ) J2UXE8 WP_008105386.1 403 BLUF+EAL 1420 312 Pantoea stewartii subsp. stewartii DC283 P(γ) H3RKF0 WP_006122006.1 134 Short-BLUF 1421 H3RCE8 WP_006119001.1 403 BLUF+EAL 1422 313 Pantoea vagans C9-1 (Pantoea agglomerans C9-1) P(γ) E1SBR1 YP_003930829.1 403 BLUF+EAL 1423 E1PKB3 YP_003929520.1 404 BLUF+EAL 1424 E1PKA4 YP_003929511.1 409 BLUF+EAL 1425 314 Pectobacterium carotovorum P(γ) WP_010274875.1 406 BLUF+EAL 1426 315 Perlucidibaca piscinae P(γ) WP_022956463.1 150 Short-BLUF 1427 316 Plautia stali symbiont P(γ) YP_008652566.1 149 Short-BLUF 1428 YP_008649935.1 398 BLUF+EAL 1429 WP_010615636.1 386 BLUF+EAL 1430 317 Pseudoalteromonas atlantica P(γ) WP_011573653.1 138 Short-BLUF 1431 Pseudoalteromonas atlantica (T6c / BAA-1087) P(γ) Q15XU6 YP_660346.1 138 Short-BLUF 1432 Q15W34 YP_660958.1 133 Short-BLUF 1433 318 Pseudoalteromonas citrea P(γ) WP_010367293.1 139 Short-BLUF 1434 Pseudoalteromonas citrea NCIMB 1889 P(γ) U1KR28 WP_010361781.1 145 Short-BLUF 1435 319 Pseudoalteromonas luteoviolacea P(γ) WP_023398227.1 138 Short-BLUF 1436 WP_023397937.1 143 Short-BLUF 1437 Pseudoalteromonas luteoviolacea B = ATCC 29581 P(γ) L8D6G6 WP_005493992.1 144 Short-BLUF 1438 L8DBD1 WP_005493516.1 139 Short-BLUF 1439 320 Pseudoalteromonas marina mano4 P(γ) U1JNR5 WP_010557655.1 141 Short-BLUF 1440 321 Pseudoalteromonas rubra ATCC 29570 P(γ) U1LSW8 WP_010383116.1 142 Short-BLUF 1441 322 Pseudoalteromonas ruthenica P(γ) WP_022946637.1 140 Short-BLUF 1442 323 Pseudoalteromonas sp. BSi20311 P(γ) G7EN43 WP_008108394.1 141 Short-BLUF 1443 Pseudoalteromonas sp. BSi20439 P(γ) G7FK05 GAA73478.1 141 Short-BLUF 1444 Pseudoalteromonas sp. BSi20480 P(γ) G7FLG8 WP_008127010.1 141 Short-BLUF 1445 Pseudoalteromonas sp. BSi20652 P(γ) G7ED85 WP_008166519.1 141 Short-BLUF 1446 Pseudoalteromonas sp. PAMC 22718 P(γ) WP_016900061.1 141 Short-BLUF 1447 Pseudoalteromonas sp. SM9913 P(γ) E6RIH7 YP_004067295.1 138 Short-BLUF 1448 324 Pseudoalteromonas spongiae P(γ) WP_010558562.1 143 Short-BLUF 1449 WP_010562063.1 142 Short-BLUF 1450 325 Pseudoalteromonas tunicata D2 P(γ) A4C8E2 WP_009838119.1 140 Short-BLUF 1451 A4CA03 WP_009840043.1 133 Short-BLUF 1452 326 Pseudoalteromonas undina NCIMB 2128 P(γ) U1MG36 WP_010392015.1 141 Short-BLUF 1453 327 Pseudomonas alcaligenes NBRC 14159 P(γ) U2ZK93 WP_021699986.1 144 Short-BLUF 1454 328 Pseudomonas alcaliphila P(γ) WP_017675860.1 144 Short-BLUF 1455 329 Pseudomonas pseudoalcaligenes CECT 5344 P(γ) I7K7F2 WP_003463988.1 267 Short-BLUF 1456 330 Psychrobacter aquaticus P(γ) WP_021813036.1 174 Short-BLUF 1457 WP_021815321.1 156 Short-BLUF 1458 WP_021812947.1 202 Short-BLUF 1459 WP_021813035.1 145 Short-BLUF 1460 WP_021814263.1 210 Short-BLUF 1461 WP_021815442.1 168 Short-BLUF 1462 331 Psychrobacter arcticum P(γ) Q4FUS2 YP_263670.1 210 Short-BLUF 1463 332 Psychrobacter cryohalolentis (strain K5) P(γ) Q1QDR2 YP_579675.1 210 Short-BLUF 1464 Q1Q9K9 YP_581128.1 196 Short-BLUF 1465 Q1QAA1 YP_580886.1 169 Short-BLUF 1466

A63

333 Psychrobacter lutiphocae P(γ) WP_019674133.1 215 Short-BLUF 1467 WP_019672901.1 213 Short-BLUF 1468 334 Psychrobacter sp. 1501(2011) P(γ) F5SNV9 WP_007394103.1 209 Short-BLUF 1469 F5SLW1 WP_007393405.1 216 Short-BLUF 1470 Psychrobacter sp. G P(γ) S4YVW0 YP_008163550.1 169 Short-BLUF 1471 T1EBM8 YP_008163896.1 207 Short-BLUF 1472 S4YSN3 YP_008162349.1 210 Short-BLUF 1473 Psychrobacter sp. PAMC 21119 P(γ) WP_010201341.1 172 Short-BLUF 1474 WP_010201340.1 145 Short-BLUF 1475 WP_010196365.1 207 Short-BLUF 1476 WP_010201745.1 208 Short-BLUF 1477 Psychrobacter sp. PRwf-1 P(γ) A5WCY1 YP_001279472.1 209 Short-BLUF 1478 A5WEX6 YP_001280167.1 216 Short-BLUF 1479 335 Psychromonas ingrahamii (strain 37) P(γ) A1SZ77 YP_944391.1 157 Short-BLUF 1480 336 Rahnella aquatilis ATCC 33071 P(γ) H2J1E2 YP_005220397.1 413 BLUF+EAL 1481 Rahnella aquatilis HX2 P(γ) H8P0G4 YP_005419028.1 413 BLUF+EAL 1482 337 Rahnella sp. (strain Y9602) P(γ) E8XZI5 YP_004215373.1 413 BLUF+EAL 1483 338 Reinekea sp. MED297 A4BGV1 WP_008047183.1 172 Short-BLUF 1484 339 Rheinheimera sp. A13L P(γ) F7NUK1 WP_008898335.1 141 Short-BLUF 1485 340 Salinisphaera shabanensis E1L3A P(γ) F7Q923 WP_006913789.1 142 Short-BLUF 1486 341 Serratia sp. M24T3 P(γ) I0QUJ8 WP_009636506.1 404 BLUF+EAL 1487 342 Shewanella oneidensis P(γ) Q8EBA3 NP_719171.1 140 Short-BLUF 1488 343 Shewanella woodyi ATCC 51908 P(γ) B1KH49 YP_001762456.1 156 Short-BLUF 1489 344 Shigella boydii 4444-74 P(γ) I6EHF9 EIQ43451.1/WP_000958290.1 133 Short-BLUF 1490 Shigella boydii 5216-82 P(γ) F3WJP8 WP_004992970.1 372 BLUF+EAL 1491 Shigella boydii 965-58 P(γ) I6DEL8 WP_004999597.1 403 BLUF+EAL 1492 Shigella boydii ATCC 9905 P(γ) E7T1P3 WP_004976550.1 372 BLUF+EAL 1493 345 Shigella dysenteriae 1012 P(γ) B3X612 WP_005013749.1 311 BLUF+ EAL 1494 Shigella dysenteriae 155-74 P(γ) F3V2I3 WP_000958286.1 342 BLUF+EAL 1495 346 Shigella flexneri 1485-80 P(γ) K0XUP4 EJZ67510.1/WP_000958290.1 133 Short-BLUF 1496 Shigella flexneri 2850-71 P(γ) I6BWJ3 WP_005109173.1 261 BLUF+EAL 1497 Shigella flexneri CCH060 P(γ) I6C3N2 EIQ14124.1/WP_000958290.1 133 Short-BLUF 1498 Shigella flexneri J1713 P(γ) F7R7D0 WP_005101736.1 386 BLUF+EAL 1499 Shigella flexneri VA-6 P(γ) F5N0U1 WP_005067857.1 372 BLUF+EAL 1500 347 Shigella sonnei 53G P(γ) E7K4N8 WP_005140026.1 198 Short-BLUF 1501 348 Shigella sp. D9 P(γ) F4NHE2 EGJ05355.1/WP_000243121.1 429 BLUF+EAL 1502 349 Simiduia agarivorans SA1 = DSM 21679 P(γ) YP_006916092.1 176 Short-BLUF 1503 350 Spongiibacter tropicus P(γ) WP_022958549.1 139 Short-BLUF 1504 351 Stenotrophomonas maltophilia P(γ) WP_019661581.1 139 Short-BLUF 1505 WP_019659714.1 155 Short-BLUF 1506 Stenotrophomonas maltophilia Ab55555 P(γ) J7V2U9 WP_005408981.1/YP_001971521.1 144 Short-BLUF 1507 J7VQR4 WP_005409694.1 155 Short-BLUF 1508 Stenotrophomonas maltophilia AU12-09 P(γ) M5TMH3 WP_005416006.1 144 Short-BLUF 1509 M5TWK9 WP_005416570.1 155 Short-BLUF 1510 Stenotrophomonas maltophilia D457 P(γ) I0KM94 YP_006184358.1 144 Short-BLUF 1511 I0KNV6 YP_006184918.1 155 Short-BLUF 1512 Stenotrophomonas maltophilia EPM1 P(γ) M3FAW7 YP_001971521.1 144 Short-BLUF 1513 Stenotrophomonas maltophilia EPM1 P(β) M3G6A4 WP_005413472.1 155 Short-BLUF 1514 Stenotrophomonas maltophilia JV3 P(γ) G0JUR4 YP_004792041.1 144 Short-BLUF 1515

A64

G0K4E1 YP_004794149.1 143 Short-BLUF 1516 G0JY27 YP_004792350.1 142 Short-BLUF 1517 Stenotrophomonas maltophilia K279a P(γ) B2FSB2 YP_001972310.1 155 Short-BLUF 1518 B2FNU4 YP_001971901.1 144 Short-BLUF 1519 B2FSB7 YP_001972315.1 132 Short-BLUF 1520 B2FK66 CAQ45217.1/YP_001971521.1 144 Short-BLUF 1521 B2FSU5 YP_001972350.1 157 Short-BLUF 1522 B2FSA5 YP_001972303.1 149 Short-BLUF 1523 Stenotrophomonas maltophilia MF89 P(γ) T5KGS5 WP_019658901.1 144 Short-BLUF 1524 T5L8X7 WP_021202418.1 155 Short-BLUF 1525 Stenotrophomonas maltophilia RA8 P(γ) M5D728 YP_002027818.1 144 Short-BLUF 1526 Stenotrophomonas maltophilia R551-3 P(γ) B4STM1 YP_002028128.1 142 Short-BLUF 1527 B4SR64 ACF51135.1/YP_002027818.1 144 Short-BLUF 1528 Stenotrophomonas maltophilia SKK35 P(γ) M5CLY6 CCP10895.1 144 Short-BLUF 1529 Stenotrophomonas sp. SKA14 P(γ) B8L2D7 WP_008267235.1 144 Short-BLUF 1530 B8LAI7 WP_008268182.1 142 Short-BLUF 1531 352 Teredinibacter turnerae P(γ) WP_018415581.1 138 Short-BLUF 1532 WP_018276843.1 138 Short-BLUF 1533 353 Thioalkalimicrobium aerophilum AL3 P(γ) G4D9V3 WP_006459896.1 135 Short-BLUF 1534 354 Thioalkalivibrio sp. HL-EbGR7 P(γ) B8GPZ7 YP_002515131.1 168 Short-BLUF 1535 Thioalkalivibrio sp. K90mix P(γ) D3SBJ7 YP_003461138.1 196 Short-BLUF 1536 355 Thiocystis violascens (Chromatium violascens) ATCC 17096 P(γ) I3YBW9 YP_006414612.1 597 GGDEF+EAL+BLUF 1537 356 Thioflavicoccus mobilis 8321 P(γ) L0H2H2 YP_007245882.1 293 BLUF+PsiE 1538 357 Thiorhodococcus drewsii AZ1 P(γ) G2DZK4 WP_007040181.1 1199 2PAS+GGDEF+EAL+BLUF 1539 G2E4Y1 WP_007042057.1 151 Short-BLUF 1540 358 Thiorhodospira sibirica ATCC 700588 P(γ) G4E7K7 WP_006788315.1 139 Short-BLUF 1541 G4E8F6 WP_006788612.1 1099 2PAS+GGDEF+EAL+BLUF 1542 359 Thiorhodovibrio sp. 970 P(γ) H8Z515 WP_009150825.1 148 Short-BLUF 1543 H8Z1A9 WP_009148009.1 299 Short-BLUF 1544 360 uncultured gamma proteobacterium P(γ)U H5SE04 BAL54390.1 113 Short-BLUF 1545 361 uncultured Thiohalocapsa sp. PB-PSB1 P(γ) WP_023410594.1 183 Short-BLUF 1546 WP_023414210.1 149 Short-BLUF 1547 362 Vibrio P(γ) WP_017060344.1 139 Short-BLUF 1548 363 Vibrio breoganii P(γ) WP_017029863.1 141 Short-BLUF 1549 WP_017031909.1 141 Short-BLUF 1550 364 Vibrio cholera RC385 P(γ) D7HCX4 WP_001885575.1 142 Short-BLUF 1551 Vibrio cholerae P(γ) WP_019829651.1 142 Short-BLUF 1552 365 Vibrio coralliilyticus ATCC BAA-450 P(γ) C9NR36 WP_006958871.1 139 Short-BLUF 1553 C9NQ17 WP_006958783.1 136 Short-BLUF 1554 C9NPY7 WP_006958749.1 104 Short-BLUF 1555 C9NVS2 WP_006961401.1 141 Short-BLUF 1556 Vibrio coralliilyticus OCN008 P(γ) U0ET87 WP_019275344.1 141 Short-BLUF 1557 366 Vibrio crassostreae P(γ) WP_017065379.1 139 Short-BLUF 1558 WP_017067227.1 139 Short-BLUF 1559 WP_017070503.1 139 Short-BLUF 1560 367 Vibrio cyclitrophicus P(γ) WP_016768597.1 139 Short-BLUF 1561 WP_010440401.1 139 Short-BLUF 1562 WP_016796603.1 139 Short-BLUF 1563 WP_016793122.1 139 Short-BLUF 1564

A65

368 Vibrio genomosp. F10 P(γ) WP_017038440.1 139 Short-BLUF 1565 WP_017034560.1 139 Short-BLUF 1566 Vibrio genomosp. F6 P(γ) WP_017052207.1 139 Short-BLUF 1567 369 Vibrio ichthyoenteri ATCC 700023 P(γ) F9S3C4 WP_006712577.1 134 Short-BLUF 1568 370 Vibrio nigripulchritudo P(γ) WP_022604223.1 138 Short-BLUF 1569 YP_008620961.1 138 Short-BLUF 1570 WP_022589537.1 127 Short-BLUF 1571 WP_022600546.1 127 Short-BLUF 1572 YP_008641840.1 127 Short-BLUF 1573 Vibrio nigripulchritudo ATCC 27043 P(γ) F9THX2 WP_004400464.1 138 Short-BLUF 1574 P(γ) F9TGM9 EGU61078.1/WP_004399602.1 127 Short-BLUF 1575 371 Vibrio ordalii P(γ) WP_010320661.1 145 Short-BLUF 1576 372 Vibrio orientalis CIP 102891 = ATCC 33934 P(γ) C9QIB2 WP_004414323.1 60 Short-BLUF 1577 373 Vibrio scophthalmi LMG 19158 P(γ) F9RIQ0 WP_005592861.1 139 Short-BLUF 1578 374 Vibrio sinaloensis DSM 21326 P(γ) E8M6S4 WP_008076812.1 139 Short-BLUF 1579 375 Vibrio sp. MED222 P(γ) A3Y2H2 WP_009847120.1 142 Short-BLUF 1580 376 Vibrio splendidus P(γ) WP_017079037.1 139 Short-BLUF 1581 WP_017090104.1 139 Short-BLUF 1582 WP_017093202.1 139 Short-BLUF 1583 WP_017073405.1 139 Short-BLUF 1584 WP_019824217.1 139 Short-BLUF 1585 Vibrio splendidus 12B01 P(γ) A3UYZ3 WP_004734641.1 141 Short-BLUF 1586 Vibrio splendidus Mel32 P(γ) B7VGM9 YP_002417504.1 139 Short-BLUF 1587 377 Vibrio tasmaniensis P(γ) WP_017097344.1 139 Short-BLUF 1588 378 Vibrio tubiashii ATCC 19109 P(γ) F9T3Q3 EGU56983.1/WP_004744136.1 151 Short-BLUF 1589 Vibrio tubiashii NCIMB 1337 = ATCC 19106 P(γ) I1DCC9 WP_004744136.1 151 Short-BLUF 1590 379 Vibrio vulnificus P(γ) WP_017420365.1 139 Short-BLUF 1591 Vibrio vulnificus P(γ) WP_017790365.1 139 Short-BLUF 1592 380 Vibrionales bacterium SWAT-3 P(γ) A5L553 WP_008222460.1 139 Short-BLUF 1593 381 Xanthomonadaceae P(γ) WP_010486035.1 144 Short-BLUF 1594 382 Xanthomonas axonopodis P(γ) WP_016850851.1 159 Short-BLUF 1595 WP_017158845.1 158 Short-BLUF 1596 WP_017156640.1 159 Short-BLUF 1597 383 Xanthomonas axonopodis pv. citri str.306 P(γ) Q8PHH6 AAM38122.1/NP_643586.1 147 Short-BLUF 1598 Q8PKP9 AAM36973./NP_642437.1 158 Short-BLUF 1599 384 Xanthomonas axonopodis pv. punicae str. LMG 859 P(γ) H1XN33 WP_005934425.1 128 Short-BLUF 1600 Xanthomonas axonopodis Xac29-1 P(γ) M4TW81 YP_007636565.1/NP_642437.1 158 Short-BLUF 1601 M4TZI7 NP_643586.1 147 Short-BLUF 1602 385 Xanthomonas citri pv. mangiferaeindicae LMG 941 P(γ) H8FLF5 WP_003490419.1 158 Short-BLUF 1603 386 Xanthomonas citri subsp. citri Aw12879 P(γ) M4WEN8 NP_642437.1 158 Short-BLUF 1604 387 Xanthomonas fuscans subsp. aurantifolii str. ICPB 10535 P(γ) D4TC91 WP_007975774.1 147 Short-BLUF 1605 D4SRA6 WP_007962696.1 159 Short-BLUF 1606 388 Xanthomonas fuscans subsp. fuscans P(γ) YP_008638953.1 159 Short-BLUF 1607 389 Xanthomonas perforans 91-118 P(γ) F0BUQ3 WP_008575691.1 184 Short-BLUF 1608 390 Xanthomonas sp. M97 P(γ) WP_022971905.1 144 Short-BLUF 1609 391 Bacteriovorax sp. BAL6_X P(δ) T0C040 WP_021268210.1 153 Short-BLUF 1610 392 Bdellovibrio bacteriovorus str. Tiberius P(δ) K7YL37 YP_007021703.1 142 Short-BLUF 1611 393 Desulfatibacillum alkenivorans AK-01l P(δ) B8FK53 YP_002430196.1 144 Short-BLUF 1612 394 Desulfococcus oleovorans Hxd3 P(δ) A9A0H4 YP_001529551.1 148 Short-BLUF 1613

A66

395 Desulfovibrio longus P(δ) WP_022663022.1 146 Short-BLUF 1614 396 Myxococcus xanthus DK1622 P(δ) Q93SK7 253 Short-BLUF 1615 397 uncultured Desulfofustis sp. PB-SRB1 P(δ)Unc WP_023408928.1 144 Short-BLUF 1616 398 Magnetococcus sp. MC-1 P(Magn) A0LAZ4 YP_866543.1 1118 PAS+GGDEF+EAL+BLUF 1617 A0L5S5 YP_864724.1 139 Short-BLUF 1618 A0LAQ1 YP_866450.1 160 Short-BLUF 1619 399 Thiovulum sp. ES P(ε) J0L733 WP_008350312.1 143 Short-BLUF 1620 J1FAS2 WP_008350313.1 143 Short-BLUF 1621 400 zeta proteobacterium SCGC AB-137-C09 P(ζ) WP_018281521.1 291 BLUF+PsiE 1622 401 candidate division TG3 bacterium ACht1 Unc WP_022635648.1 141 Short-BLUF 1623 402 uncultured bacterium Unc K2GM21 EKE24165.1 122 Short-BLUF 1624 403 uncultured bacterium 581 PUnc Q6SFE3 AAR38275.1/WP_007234700.1 159 Short-BLUF 1625 404 uncultured proteobacterium delRiverFos06H03 PUnc Q58PP1 AAX48191.1 147 Short-BLUF 1626 405 uncultured proteobacterium. PUnc Q8KZ47 AAM48626.1 146 Short-BLUF 1627 406 Cyanothece sp. PCC 7425 / ATCC 29141 Cya B8HWP0 YP_002484827.1 145 Short-BLUF 1628 407 Halothece sp. PCC 7418 (Synechococcus sp. PCC 7418) Cya K9YCI0 YP_007168017.1 163 Short-BLUF 1629 408 Oscillatoria acuminata PCC 6304 Cya K9TLZ5 YP_007087096.1 366 BLUF+GGDEF 1630 409 Pseudanabaena biceps PCC 7429 Cya L8MTI5 WP_009629186.1 370 BLUF+GGDEF 1631 410 Synechococcus sp. (strain ATCC 27167 / PCC 6312) Cya K9RSY2 YP_007060755.1 141 Short-BLUF 1632 Synechococcus sp. PCC 7002 Cya B1XJZ3 YP_001734377.1 145 Short-BLUF 1633 Synechococcus sp. PCC 7502 Cya K9SXI7 YP_007106786.1 153 Short-BLUF 1634 411 Synechocystis sp. PCC 6803 Cya L8AQ59 NP_441709.1 150 Short-BLUF 1635 F7UR00 BAK50562.1/YP_005651767.1 150 Short-BLUF 1636 P74295 YP_005651767.1/NP_441709.1 150 Short-BLUF 1637 Synechocystis sp. PCC 6803 substr. GT-I Cya H0NXE6 YP_005383576.1 150 Short-BLUF 1638 Synechocystis sp. PCC 6803 substr. PCC-N Cya H0P9U8 YP_005409452.1 150 Short-BLUF 1639 Synechocystis sp. PCC 6803 substr. PCC-P Cya H0PNV0 YP_005386745.1 150 Short-BLUF 1640 412 Thermosynechococcus elongatus Cya Q8DMN3 NP_680869.1 143 Short-BLUF 1641 413 Rhodopirellula baltica Pl Q7UXU1 NP_864233.1 141 Short-BLUF 1642 Rhodopirellula baltica WH47 Pl F2AXT1 WP_007328441.1 132 Short-BLUF 1643 414 Rhodopirellula europaea SH398 Pl M5S3C7 WP_008667793.1 141 Short-BLUF 1644 415 Rhodopirellula sallentina SM41 Pl M5U559 WP_008676976.1 166 Short-BLUF 1645 Rhodopirellula sp. SWK7 Pl M5SVB2 WP_009104720.1 154 Short-BLUF 1646 M5TST8 WP_009093809.1 184 Short-BLUF 1647 416 Candidatus Nitrospira defluvii Nit D8PAY1 YP_003796316.1 138 Short-BLUF 1648 417 Bdellovibrio bacteriovorus Bact Q6MPS8 NP_967726.1 142 Short-BLUF 1649 418 Cellulophaga algicola DSM 14237 Bact E6X5L6 YP_004163880.1 144 Short-BLUF 1650 419 Cesiribacter andamanensis AMV16 Bact M7N429 WP_009196222.1 143 Short-BLUF 1651 420 Chloroherpeton thalassium ATCC 35110 Bact B3QX03 YP_001997260.1 145 Short-BLUF 1652 421 Cytophagales str. B6 Bact WP_022830361.1 140 Short-BLUF 1653 422 Dokdonia donghaensis MED134 Bact A2TPW0 EAQ40501.1 135 Short-BLUF 1654 423 Eudoraea adriatica Bact WP_019668996.1 146 Short-BLUF 1655 424 Fibrella aestuarina BUZ 2 Bact I0KAE1 YP_007321687.1 143 Short-BLUF 1656 425 Fibrisoma limi BUZ 3 Bact I2GNV8 WP_009284154.1 229 Short-BLUF 1657 426 Flavobacteria bacterium BBFL7 Bact Q26D86 WP_006795753.1 139 Short-BLUF 1658 427 Flavobacteriaceae bacterium P7-3-5 Bact WP_019387910.1 136 Short-BLUF 1659 428 Formosa agariphila KMM 3901 Bact CDF79453.1 144 Short-BLUF 1660 429 Fulvivirga imtechensis AK7 Bact L8JX15 WP_009577900.1 139 Short-BLUF 1661 430 Gillisia limnaea DSM 15749 Bact H2BX58 WP_006988327.1 134 Short-BLUF 1662 H2BW61 WP_006989286.1 133 Short-BLUF 1663

A67

H2BVP6 WP_006990305.1 135 Short-BLUF 1664 H2BX59 WP_006988328.1 135 Short-BLUF 1665 431 Gramella forsetii KT0803 Bact A0LYB8 YP_860431.1 133 Short-BLUF 1666 432 Hymenobacter aerophilus Bact WP_019949502.1 139 Short-BLUF 1667 WP_019946446.1 145 Short-BLUF 1668 WP_019946896.1 145 Short-BLUF 1669 433 Hymenobacter norwichensis Bact WP_022823388.1 142 Short-BLUF 1670 WP_022823740.1 153 Short-BLUF 1671 WP_022821755.1 146 Short-BLUF 1672 434 Krokinobacter sp. (strain 4H-3-7-5) Bact F4B036 YP_004431557.1 137 Short-BLUF 1673 F4B057 YP_004431578.1 151 Short-BLUF 1674 435 Marivirga tractuosa ATCC 23168 Bact E4TNQ3 YP_004053598.1 139 Short-BLUF 1675 436 Mesoflavibacter zeaxanthinifaciens Bact WP_010517271.1 142 Short-BLUF 1676 437 Microscilla marina ATCC 23134 Bact A1ZRF7 WP_004156404.1 137 Short-BLUF 1677 438 Mucilaginibacter paludis DSM 18603 Bact H1Y0M8 WP_008509682.1 140 Short-BLUF 1678 H1YF64 WP_008506222.1 151 Short-BLUF 1679 H1Y0M7 WP_008509681.1 137 Short-BLUF 1680 H1Y8V0 WP_008509607.1 151 Short-BLUF 1681 439 Nafulsella turpanensis Bact WP_017730115.1 142 Short-BLUF 1682 440 Pedobacter sp. BAL39 Bact A6E9F4 WP_008239021.1 152 Short-BLUF 1683 440 Polaribacter dokdonensis MED152 Bact A2TY78 YP_007671791.1 481 HTH-BLUF 1684 440 Psychroflexus gondwanensis ACAM 44 Bact N1WKU3 WP_003440963.1 142 Short-BLUF 1685 440 Psychroflexus torquis ATCC 700755 Bact K4IV57 YP_006868110.1 142 Short-BLUF 1686 440 Segetibacter koreensis Bact WP_018614590.1 151 Short-BLUF 1687 440 Spirosoma linguale DSM 74 Bact D2QRB5 YP_003388468.1 142 Short-BLUF 1688 D2QVZ0 YP_003391771.1 137 Short-BLUF 1689 441 Spirosoma spitsbergense Bact WP_020603065.1 152 Short-BLUF 1690 Spirosoma spitsbergense Bact WP_020601880.1 152 Short-BLUF 1691 442 Terriglobus saanensis ATCC BAA-1853 Bact E8UXB9 YP_004184137.1 153 Short-BLUF 1692 443 unidentified eubacterium SCB49 Bact A6ENE1 EDM45157.1 133 Short-BLUF 1693 444 Winogradskyella psychrotolerans Bact WP_020894508.1 136 Short-BLUF 1694 445 Zobellia galactanivorans DSM 12802 Bact G0L2R9 YP_004735541.1 145 Short-BLUF 1695 G0KZL8 YP_004737334.1 147 Short-BLUF 1696 446 Zunongwangia profunda SM-A87 Bact D5BH98 YP_003583468.1 133 Short-BLUF 1697 447 Solibacter usitatus Ellin6076 AcidoB Q01S10 YP_827845.1 141 Short-BLUF 1698 448 Lentisphaera araneosa HTCC2155 Lent A6DQ35 WP_007279966.1 132 Short-BLUF 1699 449 Chthoniobacter flavus Ellin428 Verr B4D369 WP_006980682.1 157 Short-BLUF 1700 450 Coraliomargarita akajimensis DSM 45221 Verr D5EM63 YP_003549393.1 148 Short-BLUF 1701 451 Verrucomicrobiae bacterium DG1235 Verr B5JMC0 WP_008104971.1 141 Short-BLUF 1702 B5JJ76 WP_008103776.1 157 Short-BLUF 1703 452 Leptonema illini DSM 21528 Spi H2CIX2 WP_002774553.1 261 BLUF+GAF ? 1704 453 Turneriella parva (Leptospira parva) ATCC BAA-1111 Spi I4B432 YP_006439545.1 353 BLUF+GGDEF 1705

A68

LEGEND

a. Domain abbreviations (according to Interpro: N. J. Mulder, R. Apweiler, T. K. Attwood, A. Bairoch, D. Barrel, A. Bateman, M. Biswas, P. Bradley, P. Bucher, R. R. Copley, E. Courcelle, U. Das, R. Durbin, L. Falquet, W. Fleischmann, S. Griffiths‐Jones, D. Haft, N. Harte, N. Hulo, D. Kahn, A. Kanapin, M. Krestyaninova, R. Lopez, I. Letunic, D. Lonsdale, V. Silventoinen, S. E. Orchard, M. Pagni, D. Peyruc, C. P. Ponting, J. Selengut, F. Servant, C. J. Sigrist, R. Vaughan and E. M. Zdobnov, The InterPro Database, 2003 brings increased coverage and new features., Nucl. Acids Res., 2003, 31, 315‐318.

BLUF Blue Light sensing Using Flavin domain CHASE Cyclases/Histidine kinases Associated Sensory Extracellular CHEB CHEB-type response regulator CHER CHER-type S-adenosylmethionine-dependent methyltransferase Cyclase Adenylyl cyclase class-3/4/guanylyl cyclase DICT Domain associated with diguanylate Cyclases and phosphodiesterases EAL Diguanylate phosphodiesterase named after conserved amino acids

GAF cGMP-specific phosphodiesterases, cyanobacterial adenylate cyclases, and formate hydrogen lyase tranGGDEF Diguanylate cyclase named after conserved amino acids Hamp linker domain in Histidine kinases, Adenyl cyclases, Methyl-accepting proteins and Phosphatases Hpt histidine phosphotransfer domain HTH Helix Turn Helix/DNA binding domain Kinase Hitidine kinase domain LOV Light Oxygen and Voltage domain, PAS subfamily; here sensors of blue light MASE1 Predicted integral membrane sensory domain found bacterial signaling proteins MCP Methyl-accepting chemotaxis proteins PAS Per Arnt Sim domain PsiE Phosphate-starvation-induced PsiE-like RR CheY-type Response regulator, receiver domain SCHIC Sensor containing heme instead of cobalamin

A69

SPOIIE Sporulation stage II, protein E C-terminal/Protein phosphatase 2C-related STAS Sulphate Transporter and AntiSigma factor antagonist TETR Tetracycline transcriptional regulator

b. Abbreviations for phyla

F Firmicutes

Ac Actinobacteria

P(α) α-proteobacteria>Caulobacterales

P(α) α-proteobacteria>Parvularculales

P(α) α-proteobacteria>Rhizobiales

P(α) α-proteobacteria>Rhodobacterales

P(α) α-proteobacteria>Rhodospirillales

P(α) α-proteobacteria>Sphingomonadales

P(α)U α-proteobacteria>Uncultured

P(α)poly α-proteobacteria>Polymorphum

P(β) β-proteobacteria>Burkholderiales

P(β) β-proteobacteria>Gallionellales

P(β) β-proteobacteria>Methylophilales

P(β) β-proteobacteria>Neisseriales

P(β) β-proteobacteria>Nitrosomonadales

P(β) β-proteobacteria>Rhodocyclales

P(β)U β-proteobacteria>Uncultured

P(γ) γ-proteobacteria>Acidithiobacillales

P(γ) γ-proteobacteria>Alteromonadales

P(γ) γ-proteobacteria>Chromatiales

P(γ) γ-proteobacteria> Enterobacteriales

A70

P(γ) γ-proteobacteria>Legionellales

P(γ) γ-proteobacteria>Methylococcales

P(γ) γ-proteobacteria>Oceanospirillales

P(γ) γ-proteobacteria>Pseudomonadales

P(γ)Rei γ-proteobacteria>Reinekea

P(γ) γ-proteobacteria>Salinisphaerales

P(γ) γ-proteobacteria>Thiotrichales

P(γ)U γ-proteobacteria>Uncultured

P(γ) γ-proteobacteria>Vibrionales

P(γ) γ-proteobacteria>Xanthomonadales

P(δ) δ-proteobacteria P(ε) ε-proteobacteria

P(Magn) Proteobacteria>Magnetococcales

Chl Chloroflexi Cya Cyanobacteria>Chroococcales

Cya Cyanobacteria>Gloeobacteria

Cya Cyanobacteria>Nostocales Cya Cyanobacteria> Oscillatoriales

Pl Planctomycetes Nit Nitrospirae Acido Acidobacteria

Bact/Ch Bacteroidetes/Chlorobi DeTh Deinococcus-Thermus Lent Lentisphaerae Verr Verrucomicrobia Spi Spirochaetes EuA Euryarchaeota

Appendix 1 - Cinecadspace-unipr.cineca.it/bitstream/1889/2452/4/APPENDIX1_domains.pdfAppendix 1...

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Transcript of Appendix 1 - Cinecadspace-unipr.cineca.it/bitstream/1889/2452/4/APPENDIX1_domains.pdfAppendix 1...