“More Stakeholders, Broader Opportunities, Broader Impact” · Thermus aquaticus. bacteria....
Transcript of “More Stakeholders, Broader Opportunities, Broader Impact” · Thermus aquaticus. bacteria....
Outcomes for Science and Society
EpigeneticsPhenotypic Plasticity
Synthesis of novel organisms
Engineered microbiomes
Origins of life
Cognition
Biomanufacturing
Mitigation of epidemics
Manage global biological resources
Secure food supply
Development
Predict evolution
Integrative Understanding and Predictive
Capability
Ecosystem Forecasting
Microbiomes
Decision-making
Bioenergy
Personalized medicine
Enable new bio-economy
URoL
Security
Economy
Manage Evolution
“More Stakeholders, Broader Opportunities, Broader Impact”
Epigenetics& behavior
Think:From Cells to
Society
Resourcegovernance
Better physical &social environments
Workforce
Synthetic cell
Orthogonal genetic polymers
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Can Zeroing In Shine Light on the Rules of Life?
Angstrom Nanometer Micron Meter Kilometer
Flow of Biological Information
RNAs ProteinsDNAs
DNA-dependent RNA polymeraseTranscription factors Ribosome
Reverse transcriptase
ReplisomeDNA polymerase
DNA ligaseSSB protein RNA-dependent RNA polymerase
ProteinsTranscription Translation
Reverse Transcription
DNA Replication RNA Replication
Environments Cells/OrganismsEnvironments
Epigenetics
Synthetic Cells
Cynthia Burrows, University of Utah1808475 Redox Photochemistry in
Genomes of Microorganisms
Jack Szostak, Harvard University1607034 Non-Enzymatic RNA Replication
Nicholas Hud, Georgia Tech1504217 The Center for Chemical Evolution The Central Dogma of Biology
Biological, Enzyme-Catalyzed RNA Replication
http://www.onlinebiologynotes.com/transcription-in-prokaryotes/; http://image.slideserve.com/516559/rna-synthesis-is-catalyzed-by-the-rna-polymerase-l.jpg
Non Enzymatic RNA Primer Extension
Wen Zhang, Chun Pong Tam, Travis Walton, Albert C. Fahrenbach, Gabriel Birrane, and Jack W. Szostak, PNAS, 2017, 114, 7659-64
Non-Enzymatic Viscosity-Driven Nucleic Acid Replication
Christine He, Isaac Gállego, Brandon Laughlin, Martha A. Grover & Nicholas V. Hud, Nature Chemistry, 2017, 9, 318–324.
Thermus aquaticusbacteria
Chlamydomonas algae
Coral in Lizard Island Great Barrier Reef Hot springs in Yellowstone National Park
Redox Photochemistry in Genomes of Microorganisms
A. M. Fleming, Y. Ding, J. Zhu, and C. J. Burrows, ACS Chem. Biol. 2017, 12, 2417-2426.https://chem.utah.edu/_images/faculty/burrows/images/publication_images/34.gif; https://news.nationalgeographic.com/2016/03/160321-coral-bleaching-great-barrier-reef-climate-change/; https://en.wikipedia.org/wiki/Chlamydomonas; http://media.web.britannica.com/eb-media/43/134843-004-D231EE08.jpg; https://news.cnrs.fr/sites/default/files/styles/lightbox; hd/public/assets/images/quadruplex_exemples_structures_adn.jpg?itok=S9PkXgjq;
Can Zeroing In Shine Light on the Understanding of the Rules of Life?
Mural by middle school students from Atlanta working with members of the Center for Chemical Evolution @ Georgia Tech.