“Circuits Development & Axon Regeneration” rd AXON Meeting · “Circuits Development & Axon...

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Programme “Circuits Development & Axon Regeneration” 3 rd AXON Meeting www.axon2019.com

Transcript of “Circuits Development & Axon Regeneration” rd AXON Meeting · “Circuits Development & Axon...

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“Circuits Development & Axon Regeneration” - 3rd AXON Meeting • 1

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Wednesday, September 11th

Programme“Circuits Development & Axon Regeneration”

3rd AXON Meeting

www.axon2019.com

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2 • “Circuits Development & Axon Regeneration” - 3rd AXON Meeting Wednesday, September 11th

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Wednesday, Sep 11th

12:00-13:45 Arrival & Registration

13:45-14:00 Welcome address: Guillermina López-Bendito and Eloísa Herrera

14:00-15:00 Keynote Speaker: Guo-li Ming, Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System. Introduced by Robert Hindges.

Session 1 Axon Guidance IChairperson: Greg Bashaw

15:00-15:30 Alain Chedotal, Evolution of commissural axon guidance mechanisms

15:30-16:00 Esther Stoeckli, Primary cilia are required in a cell-autonomous manner for neural circuit formation

16:00-16:15 Short Talk: Iona Genescu, Activity of Cajal-Retzius cells regulates their distribution and survival: impact on cortical wiring

16:15-16:45 Coffee Break

Session 2 Axon Guidance IIChairperson: Artur Kania

16:45-17:00 Short Talk: Marieke Verhagen, Layer-specific cortical development and cortical neuron spacing depend on Semaphorin6A reverse signaling

17:00-17:30 Samantha Butler, The cofilin/Limk1 pathway controls the growth rate of both developing and regenerating spinal axons

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“Circuits Development & Axon Regeneration” - 3rd AXON Meeting • 3

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Thursday, September 12th

Session 2 (continue) - Wednesday 11th

17:30-18:00 Joaquim Egea, Striatal and thalamocortical axon defects in RhoE knockout embryonic brains

18:00-20:30 Poster Session I + Drinks

20:30 Dinner

Thursday, Sep 12th

Session 3 Axon Guidance IIIChairperson: Jeroen Pasterkamp

09:00-09:30 Yimin Zou, Signaling mechanisms for glutamatergic synapse formation and function

09:30-10:00 Marie-Laure Baudet, Axonal miRNAs: gatekeepers of time and space in brain wiring

10:00-10:30 Paola Bovolenta, The role of Sfrp1 in axon guidance and synaptic plasticity

10:30-10:45 Short Talk: Maheva Andriatsilavo, Intravital live imaging of axonal growth, competition and selection

10:45-11:00 Short Talk: Farin B. Bourojeni, Changes in laterality of spinofugal projections induced by the developmental deletion of Dcc in the spinal cord

11:00-11:30 Coffee Break

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4 • “Circuits Development & Axon Regeneration” - 3rd AXON Meeting Thursday, September 12th

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Session 3 (continue) Chairperson: Carol Mason

11:30-12:00 Eloisa Herrera, Zic2 abrogates an alternative Wnt signaling pathway to convert axon attraction into repulsion

12:00-12:30 Filippo Del Bene, Reelin and Meteorin function in neural circuit wiring in the developing zebrafish CNS

12:30-12:45 Short Talk: Timothy Mosca, The Gamma-Secretase Dependent Cleavage of a Wnt Receptor Promotes Synaptic Maturation

12:45-13:00 Short Talk: Anna Hoerderer, Abolition of SNAP25 from selected groups of cortical projection neurons of Layer 5, 6 and 6b alters late stages in circuit formation, myelin maintenance and distribution of PV+ interneurons in a cell type specific manner

13:00-15:00 Lunch

Session 4 Circuit formation IChairperson: Marta Nieto

15:00-15:30 Michelle Studer,The area-patterning disease gene COUP-TFI/Nr2f1 orchestrates spontaneous activity and intrinsic excitability in the immature somatosensory cortex

15:30-16:00 Guillermina López-Bendito, Thalamic calcium waves regulate the development and plasticity of sensory cortical maps

16:00-16:30 Linda Richards, Precise timing of SATB2 and CTIP2 expression differentially regulates cortical development in marsupial and eutherian mammals

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Thursday, September 12th

Session 4 (continue)

16:30-16:45 Short Talk: Vincenzo de Paola, Illuminating human cortical axon and synaptic development in vivo

16:45-17:15 Coffee Break

17:15-18:15 Keynote Speaker: Songhai Shi, Lineage-dependent assembly of the neocortex. Introduced by Simon Hippenmeyer.

18:15-18:30 ERC Short presentation

18:30-20:30 Poster Session II + Drinks

20:30 Invited Speakers’ Dinner

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6 • “Circuits Development & Axon Regeneration” - 3rd AXON Meeting Friday, September 13th

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Friday, Sep 13th

Session 5 Circuit formation IIChairperson: Sharon Kolk

09:00-09:30 Fabrice Ango, A gephyrin code for the diversity of inhibitory synapses

09:30-10:00 Theofanis Karayannis, A developmental window for the divergence of sensory stimulus coding in cortical interneurons

10:00-10:30 Robert Hindges, Roles of Teneurins in axon outgrowth and establishing cell type-specific connections in the vertebrate visual system

10:30-10:45 Short Talk: Hirofumi Nishizumi, Circuit formation and decision making in the mouse olfactory system

10:45-11:15 Coffee Break

Session 6 Circuit formation IIIChairperson: Fred Charron

11:15-11:45 Beatriz Rico Molecular programs orchestrating the wiring of different inhibitory circuits

11:45-12:15 Esther Serrano, Transcriptional control of neuronal identity differentiation. From nematodes to mice

12:15-12:45 Joris de Wit, Proteomic dissection of the cell-surface protein repertoire specifying mossy fiber synapse identity

12:45-13:00 Short Talk: Oliver Crawley, Autophagy is Inhibited by Ubiquitin Ligase Activity in the Nervous System

13:00-15:00 Lunch

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Friday, September 13th

Session 7 Signaling & Regeneration Chairperson: Lynda Erskine

15:00-15:30 Carmen Ruiz de Almodóvar, Blood vessels regulates oligodendrocyte precursor specification via a bi-directional crosstalk

15:30-16:00 Frank Bradke, Mechanisms of Axon Growth and Regeneration

16:00-16:15 Short Talk: Kai Liu, Rewiring neuronal glycerolipid metabolism determines the extent of axon regeneration

16:15-16:30 Coffee Break

16:30-17:30 Keynote Speaker: Zhigang He, Axon Regeneration and Function Recovery after CNS Injury. Introduced by Ruediger Klein.

17:30 Concluding Remarks

18:00-20:00 Free time at the Beach

21:00 Gala Dinner (St Barbara Castle)

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8 • “Circuits Development & Axon Regeneration” - 3rd AXON Meeting Poster Sessions

Poster Session I (from number 1 to 50)Mediterraneo Room

Set up Poster: Wednesday, Sep 11th from 12:00pmTake down Poster: at the end of the session

1

A cell-autonomous role for primary cilia in the long-range guidance of commissural axonsDumoulin, Alexandre; Wilson, Nicole H.; Tucker, Kerry L.; Stoeckli, Esther T.

2

A polypharmacology approach to promoting axon regenerationLemmon Vance; Mah Kar Men; O’Neill Nicholas; Lowell Jeffery; Wu Wei; Munoz Melissa; Shi Yan; Martinez Yania; Xu Xiao-Ming; Al-Ali Hassan; Bixby John

3

Zic2 regulates Draxin to promote Neural Crest cells delaminationGiner de Gracia, Aida; Muça, Gerald; Escalante Rodríguez, Augusto; Morenilla-Palao, Cruz

4

A versatile depigmentation, clearing and labeling method provides systemic and high resolution insight into whole animal nervous systemsPende, Marko; Vadiwala, Karim; Stockinger, Alexander; Schmiedbauer, Hannah; Murawala, Prayag; Saiedeh, Saghafi; Becker, Klaus; Dekens, Marcus; Simakov, Oleg; Tanaka, Elly; Raible, Florian; Dodt, Hans Ulrich

5

A Whole Genome Library for Genetic Mosaic AnalysisContreras, Ximena; Davaatseren, Amarbayasgalan; Hansen, Andi; Amberg, Nicole; Andersen, Lill; Heger, Anna; Sonntag, Johanna; Johnson, Randy; Schwarz, Lindsay; Liqun, Luo; Ruelicke, Thomas; Hippenmeyer, Simon

6

An axon-specific Hippo-like pathway is important for axon branchingEdwards-Faret, Gabriela; Izadifar, Azadeh; Schmucker, Dietmar

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“Circuits Development & Axon Regeneration” - 3rd AXON Meeting • 9Poster Sessions

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The Angiopoietin-Tie2 pathway regulates Purkinje cell dendritic growth and self-avoidance mechanismsLuck, Robert; Adler, Heike; Kupke, Janina; Müller, Michaela; De Palma, Michele; von Engelhardt, Jako; Hellmut, Augustin; Ruiz de Almodóvar, Carmen

8

Astrocytes close a critical period of motor circuit plasticityAckerman, Sarah; Perez-Catalan, Nelson; Freeman, Marc; Doe, Chris

9

Attraction of GABAergic neurons in the midbrain by axonal forebrain-derived Netrin-1 controls dopamine neuron positioningBrignani, Sara; Raj, Divya; Schmidt, Ewoud; Adolfs, Youri; Dudukcu, Özge; Broekhoven, Mark; Moreno-Bravo, Juan; Grossouw, Laurens; De Ruiter, Anna; Chédotal, Alain; Pasterkamp, Jeroen

10

Augmin-dependent microtubule nucleation is required for brain development and function.Viais, Ricardo; Watanabe, Sadanori; Parcerisas, Antoni; Stracker, Travis; Soriano, Eduardo; Goshima, Gohta; Lüders, Jens

11

Axonal remodeling of sympathetic nervous system: a new player in pancreatic cancer developmentChauvet, Sophie; Guillot, Jérémy; Dominici, Chloé; Lucchesi, Adrien; Nguyen, Huyen; Mann, Fanny

12

Breaking Symmetry: Glial signaling induces lateralisation of a Drosophila central brain circuit.Thomas, Hummel; Rashmit, Kaur; Johann, Markovitsch; Amadeo, Mattia

13

Cables1 links repulsive Slit signaling to attractive Wnt signalingZuñiga, Nikole; Stoeckli, Esther

14

Cas adaptor proteins regulate cortical lamination and circuit formationRiccomagno, Martin; Wenny, Wong

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10 • “Circuits Development & Axon Regeneration” - 3rd AXON Meeting Poster Sessions

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CBP and P300 are individually indispensable for the differentiation of neural progenitors and are jointly required for their proliferationGonzález-Martínez, Rocio; Del Blanco, Beatriz; Barco, Angel; Herrera, Eloisa

16

Cell-Autonomous and Non-Autonomous Mechanisms Controlling Projection Neuron MigrationHansen, Andi H.; Renno, Justine; Streicher, Carmen; Laukoter, Susanne; Pauler, Florian M.; Andersen, Lill; Ruelicke, Thomas; Hippenmeyer, Simon

17

Cell-specific transcriptomics of commissural neuronsArgentini, Manuela; Roig Puiggros, Sergi; Friocourt, François; Riancho, Luisa; Munier, Annie; Zagar, Yvrick; Teo, Shaun; Tessier-Lavigne, Marc; Chédotal, Alain

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Cell-Type Specificity of Genomic Imprinting in Cerebral CortexLaukoter, Susanne; Pauler, Florian M.; Beattie, Robert; Amberg, Nicole; Hansen, Andi H.; Streicher, Carmen; Penz, Thomas; Bock, Christoph; Hippenmeyer, Simon

19

Characterization of molecular determinants for cell type specific wring in central amygdala using single cell RNA-seqHe, Songwei; Alcala Morales, Pilar L.; Mayer, Christian; Klein, Rüdiger

20

CPT1C-sensing of nutrients regulates axon growthNuria, Casals; Marta, Palomo; Miguel, Baena; Maria, Casas; Aina, Roig; Marta, Perez; Camilla, Raiborg; Harald, Stenmark; Rut, Fadó

21

Crossing the Midline Requires Sequential Proteolysis of the Frazzled Axon Guidance ReceptorZang, Yixin; Bashaw, Greg J.

22

Cux1 represses progenitor proliferation and RGC differentiation in the mouse retinaKaimakis, Polynikis; Weiss, Linnea; Nieto, Marta; Bovolenta, Paola

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“Circuits Development & Axon Regeneration” - 3rd AXON Meeting • 11Poster Sessions

23

Deciphering the functions of SlitC and SlitN signaling during spinal commissural axon guidanceHugo, Ducuing; Thibault, Gardette; Aurora, Pignata; Muriel, Bozon; Karine, Kindbeiter; Servane, Tauszig-Delamasure; Valérie, Castellani

24

Developmental characterization of neuronal subpopulations involved in visually guided behaviorsEsteves, Bernardo; Martins, João; Viegas, Mariana; Renninger, Sabine; Orger, Michael; Diez del Corral, Ruth

25

Differential activation of a novel non-canonical, ß-catenin-dependent Wnt pathway controls axon guidance decisions at the midline.Morenilla-Palao, Cruz; López-Cáscales, Maria Teresa; López-Atalaya, José; Baeza, Diana; Barco, Angel; Herrera, Eloísa

26

Discovery of neuronal wiring functions for cell surface receptors through interactomics and structural, functional and evolutionary analysisOzkan, Engin; Cheng, Shouqiang; Rosen, Matthew; Ashley, James; Carrillo, Robert

27

DSCAM: an adhesion molecule?Kozak, Sandra; Bhowmick, Tuhin; Seven, Alpay Burak; Mertens, Haydyn; Sachse, Sonja; Chegkazi, Magda; Svergun, Dmitri; Schmucker, Dietmar; Skiniotis, Georgios; Meijers, Rob

28

Effects of the interaction between chronic stress and Otx2 expression on the habenula-interpeduncular system functionsRakotobe, Malalaniaina; Ruiz-Reig, Nuria; Bethus, Ingrid; Le Menn, Gwenaëlle; Huditz, Hannah-Isadora; Marie, Hélène; Lamonerie, Thomas; D’Autréaux, Fabien

29

Endocannabinoid signaling triggers inhibitory bouton growth at dendritic locations with strong excitatory synaptic activityCorette, Wierenga

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12 • “Circuits Development & Axon Regeneration” - 3rd AXON Meeting Poster Sessions

30 Endoglycan plays a role in axon guidance and neuronal migration by negatively regulating cell-cell adhesionTsapara, Georgia; Baeriswyl, Thomas; Dumoulin, Alexandre; Frei, Jeannine A.; Helbling, Denise; Niederkofler, Vera; Schaettin, Martina; Wilson, Nicole H.; Gesemann, Matthias; Stoeckli, Esther T.

31

Extracellular phosphorylation drives the formation of neuronal circuitryPhilippe, Monnier; Hidekyio, Harada; Jason, Charish; Nahal, Farhani

32

Floor plate-derived Ntn-1 is necessary for the proper guidance of the corticospinal tract at the pyramidal decussation and the lateralization of motor controlPourchet, Oriane; Morel, Marie-Pierre; Welniarz, Quentin; Sarrazin, Nadège; Doulazmi, Mohamed; Marti, Fabio; Faure, Philippe; Chédotal, Alain; Dusart, Isabelle; Roze, Emmanuel

33

Formation of interhemispheric connections in the opossum brainBartkowska, Katarzyna; Sobolewska, Paulina; Tarabykin, Victor; Turlejski, Krzysztof; Djavadian, Ruzanna

34

Fueling axonal regeneration: dendritic energy to the rescue?Lieve, Moons; An, Beckers; Lien, Andries; Annelies, Van Dyck; Luca, Masin; Kim, Lemmens; Lies, De Groef

35

Functional analysis of cortical malformation associated with the microtubule-related protein Kif2aRuiz-Reig, Nuria; Cerminara, Lisa; Tissir, Fadel

36

Galvanotropism enables navigating axons to locate their target at a distanceDinvaut, Sarah; Pascual, Olivier; Ferrigno, Rosaria; Moret, Frédéric; Falk, Julien; Castellani, Valérie

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“Circuits Development & Axon Regeneration” - 3rd AXON Meeting • 13Poster Sessions

37

Genetic dissection of the neural basis of binocular depth perception demonstrates an essential role for ipsilateral retinal projectionsCharron, Frederic

38

Glial Insulin regulates two-faced Gogo that acts together with or against Flamingo in navigating photoreceptor axons in DrosophilaHiroki, Takechi; Satoko, Hakeda-Suzuki; Takashi, Suzuki

39

Hidden mRNA isoforms diversify the cell surface proteome in neural development and diseaseKay, Jeremy; Ray, Thomas; Cochran, Kelly; Alexander, Graham; Arshavsky, Vadim; Kay, Jeremy

40

How axon guidance happens: From biochemistry and statistical physics to cell biology and neuroanatomy in development of the TSM1 axon of DrosophilaGiniger, Edward; Clarke, Akanni; Fang, Hsiao-Yu; McQueen, Philip

41

Identification of cellular, functional and genetic causes of Hoxb1null sensorineural hearing lossDi Bonito, Maria; Tizzano, Monica; Avallone, Bice; Harrus, Anne-Gabrielle; Bourien, Jérôme; Nouvian, Régis; Studer, Michèle

42

Investigation into mechanisms of synapse maintenance and restorationHeckman, Emily; Doe, Chris

43

Kinetic restriction of synaptic partner choice through autophagy in axonal filopodiaKiral, Ferdi Ridvan; Linneweber, Gerit; Georgiev, Svilen; Bassem, Hassan; Von Kleist, Max; Hiesinger, Peter Robin

44

Latrophilin coincident binding of Teneurin and FLRT controls neuron migration by repulsionDel Toro, Daniel; Brignani, Sara; Seyit-Bremer, Goenuel; Klein, Ruediger

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14 • “Circuits Development & Axon Regeneration” - 3rd AXON Meeting Poster Sessions

45

Local network of second messengers modelling the connectivity of the visual systemBaudet, Sarah; Ros, Oriol; Couvet, Sandrine; Zagar, Yvrick; Roche, Fiona; Nicol, Xavier

46

Mechanisms involved in intra-modal sensory, cortical plasticityAníbal-Martínez, Mar; Kitazawa, Taro; Rijli, Filippo M.; López-Bendito, Guillermina

47

Microglia-dependent development of cortical GABAergic circuitsGesuita, Lorenzo; Stachniak, Tevye; Argunsah, Ali Ozgur; De Gennaro, Martina; Utz, Sebastian; Greter, Melanie; Karayannis, Theofanis

48

Molecular and functional characterization of TRPM8-expressing mouse somatosensory neuronsHernández-Ortego, Pablo; Ordás, Purificación; Gomis, Ana; Señarís, Rosa; Viana, Félix

49

Molecular profiling of neuronal circuit developmentMohylyak, Iryna; Bengochea, Mercedes; Aerts, Stein; Hassan, Bassem

50

Morpho-dynamic changes of corneal cold sensory nerve fibers in the adult living mouseMeseguer, Victor; Iñigo-Portugués, Almudena; Borrás, Fernando; Sala, Salvador; Acosta, Maria del Carmen; Gallar, Juana; Belmonte, Carlos

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“Circuits Development & Axon Regeneration” - 3rd AXON Meeting • 15Poster Sessions

Poster Session II (from number 51 to 100)Mediterraneo Room

Set up Poster: Thursday, Sep 12th from 09:00am

Take down Poster: Friday, Sep 13th evening

51

Mud is required for axon guidance at the midline of the Drosophila central nervous systemTear, Guy; Gajendra, Sangeetha; Alsbury, Samantha; Cate, Marie-Sophie; Chung, Tek-Hong; Mitchell, Kevin

52

Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal CordBashaw, Greg J.; Gorla, Madhavi; Santiago, Celine; Chaudhari, Karina; Layman, Awo Akosua Kesewa; Oliver, Paula

53

Netrin-1 role in commissural axon guidanceRoig-Puiggros Sergi; Moreno-Bravo Juan; Mehlen Patrick; Chédotal Alain

54

Wnk regulates Nmnat and Axundead during axon morphogenesis and maintenanceAzadeh Izadifar; Julien Courchet; Tine Verreet; Derya Ayaz; Milan Petrovic; Sonja Sachse; Anke Misbaer; Sofie Vandenbogaerde; Bing Yan; Maria-Luise Erfurth; Dan Dascenco; Yoshiaki Kise; Jiekun Yan; Tommy Lewis; Franck Polleux; Dietmar Schmucker

55

Ontogeny of the Superior Colliculus at Single Cell ResolutionCheung, Giselle; Streicher, Carmen; Hippenmeyer, Simon

56

Overshooting of callosal axons from all cortical neurons reveals developmental mechanisms of highly plastic wiringNieto, Marta

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16 • “Circuits Development & Axon Regeneration” - 3rd AXON Meeting Poster Sessions

57

Phox2a defines a developmental origin of the anterolateral system and is required for supraspinal nociceptionRoome, Brian; Rastegar-Pouyani, Shima; Dumouchel, Annie; Salesse, Charleen; Thompson, William Scott; Goulding, Martyn; Johnson, Jane; Mogil, Jeff; Kmita, Marie; Kania, Artur

58

Plastic changes of innate odor quality by imprinted memory during the critical period in miceInoue, Nobuko; Nishizumi, Hirofumi; Sakano, Hitoshi

59

Plasticity of thalamic axons and cortical areas is regulated by embryonic and birth-sensitive checkpointsSinclair-Wilson, Alexander; Mailhes, Caroline; Spolidoro, Maria; Proville, Rémi; Grosschedl, Rudolf; Léna, Clément; Garel, Sonia; Lokmane, Ludmilla

60

Prefrontal cortex development in health and diseaseKolk, Sharon; Witteveen, JS; Willemsen, MH; Dombroski, TC; Brunner, HG; Martens, GJ; Pfundt, R; Kleefstra, T

61

Proteoglycan-mediated trans-axonal signaling establishes pre-target topographic sorting in the visual systemPoulain, Fabienne; Spead, Olivia

62

Ptf1a-derived neurons control mechanical itchEscalante, Augusto; Klein, Ruediger

63

Regulation of inhibitory presynaptic bouton dynamics by endocannabinoid signalingLiang, Jian; Wierenga, Corette

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“Circuits Development & Axon Regeneration” - 3rd AXON Meeting • 17Poster Sessions

64

Regulation of the Natriuretic Peptide Receptor 2 (Npr2) by Phosphorylation of Juxtamembrane Serine and Threonine Residues Is Essential for Bifurcation of Sensory AxonsSchmidt, Hannes; Dickey, Deborah; Dumoulin, Alexandre; Octave, Marie; Robinson, Jerid; Kühn, Ralf; Feil, Robert; Potter, Lincoln; Rathjen, Fritz

65

Repeat-derived mir-3470b and the regulation of neuronal network activity of mouse primary cortical neuronsMesquita Ribeiro, Raquel;

66

Repulsive EphrinA-EphA5 signalling regulates macrophage clearance in injured peripheral nervesWoodley, Patricia; Parkinson, David; Dun, Xin-Peng

67

Revisiting the role of DCC and Netrin1 in Visual system developmentVigouroux, Robin; Nguyen-Ba-Charvet, Kim; Chédotal, Alain

68

Robo recruits the Scar/Wave complex to control axon guidance at the midlineChaudhari, Karina; Bashaw, Greg J

69

Role of GABAergic synapses of oligodendrocyte progenitors in regulating axonal myelination and function of parvalbumin interneurons in inhibitory circuitBenamer, Najate; Balia, Maddalena; Angulo, Maria Cecilia

70

Role of miRNA-99a in axonal outgrowth and network connectivity in mouse primary cortical culturesLucci, Cristiano; Mesquita-Ribeiro, Raquel; Rathbone, Alex; Dajas-Bailador, Federico

71

Role of PRC2 Core Component Eed in Neural Stem Cell Lineage ProgressionAmberg, Nicole; Pauler, Florian; Simon, Hippenmeyer

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18 • “Circuits Development & Axon Regeneration” - 3rd AXON Meeting Poster Sessions

72

Role of the local regulation of synapse metabolism in synapse formation and maintenanceDascenco, Dan; Lorente Echeverria, Blanca; Marcassa, Gabriele; Vanderlinden, Jeroen; Soderling, Scott; De Wit, Joris

73

Semaphorin-6D and Plexin-A1 act in a dose-dependent and double non cell-autonomous manner for retinal axon positioning and targetingRebsam, Alexandra; Prieur, Delphine; Francius, Cédric; Gaspar, Patricia; Mason, Carol Ann

74

Single cell transcriptomics reveal Interleukin-4-dependent production of Serotonin regulates neural stem cell plasticity and neurogenesis through BDNF in Alzheimer’s disease model of zebrafish brainBhattarai, Prabesh; Cosacak, Mehmet Ilyas; Zhang, Yixin; Kizil, Caghan

75

Single-cell RNA-sequencing reveals early emergence of cortical interneuron diversityMi, Da; Li, Zhen; Lim, Lynette; Moissidis, Monika; Yang, Yifei; Gao, Tianliuyun; Pratt, Thomas; Price, David; Sestan, Nenad; Marin, Oscar

76

Spatial control of callosal axons branching through a BDNF/LKB1/NUAK1 signaling pathwayGarcia, Audrey; Meyer-Dilhet, Géraldine; Goillot, Evelyne; Courchet, Julien

77

Spatiotemporal regulation of GSK3ß levels by axonal miRNA-26a controls neuron polarisation and axon growth in primary cortical neuronsLucci, Cristiano; Mesquita-Ribeiro, Raquel; Rathbone, Alex; Dajas-Bailador, Federico

78

Split-Brain Flies: A novel developmental mechanism underlying bilateral neural circuit organizationKaur, Rashmit; Hummel, Thomas

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“Circuits Development & Axon Regeneration” - 3rd AXON Meeting • 19Poster Sessions

79

Spontaneous thalamic waves regulate cortico-thalamic innervation in the visual systemMoreno-Juan, Verónica; López-Bendito, Guillermina

80

Elucidating the multi-functionality of Semaphorin3A/Plexin-A4 signalingRon Goldner, Victor Danelon, Irena Gokhman, Edward Martinez, Tracy Tran;Avraham Yaron

81

Structure of the NELL2-Robo3 complex reveals a novel mechanism of receptor activation for axon guidanceDeLoughery, Zachary; Wang, Jing; Pak, Joseph; Acharya, Nischal; Park, Yeonwoo; Ozkan, Engin; Jaworski, Alexander

82

Studying the role of classic axon guidance molecules in peripheral nerve regenerationDun, Xin-peng; Woodley, Patricia; Singh, Lolita; Parkinson, David

83

Subcellular sorting of Neuregulins specifies the assembly of excitatory-inhibitory cortical circuitsExposito-Alonso, David; Osório, Catarina; Marín, Oscar; Rico, Beatriz

84

Sympathetic arterial innervation and guidance via EphrinaA4/EPHA4 Signaling: Arteries under pressure?Isabelle Brunet; Simonnet E.; Martin S.; Vilar J.; Pardanaud L.; Eichmann A.; Henrion D.; Sylvestre J.-S

85

TAG-1 multifunctionality coordinates neuronal migration, axon guidance, and fasciculationSuter, Tracey; Blagburn, Sara; Fisher, Sophie; Anderson-Keightly, Heather; D’Elia, Kristen; Jaworski, Alexander

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20 • “Circuits Development & Axon Regeneration” - 3rd AXON Meeting Poster Sessions

86

The absence of cGMP-mediated sensory axon bifurcation affects nociception and termination fields of afferents in the spinal cordTröster, Philip; Haseleu, Julia; Petersen, Jonas; Drees, Oliver; Schmidtko, Achim; Schwaller, Frederick; Lewin, Gary R.; Ter-Avetisyan, Gohar; Feil, Susanne; Feil, Robert; Rathjen, Fritz G.; Schmidt, Hannes

87

The AMPK-related kinase NUAK1 kinase controls axon branching through a local remodeling of metabolic pathways during developmentMarine, Lanfranchi; Audrey, Garcia; Raphael, Dos Reis; Géraldine, Meyer-Dilhet; Julien, Courchet

88

The Amyloid Precursor Protein APP collaborates with Contactin2/Axonin-1 in commissural axon guidanceSchaettin, Martina; Jabinet, Laura C; Stoeckli, Esther T.

89

The cell-adhesion glycoprotein Caspr2 contributes to axonal development in the central nervous systemCanali, Giorgia; Cifuentes-Diaz, Carmen; Garcia, Marta; Goutebroze, Laurence

90

The role of microglia in the development of forebrain axonal tractsLawrence, Akindé; Oller, Guillaume; Thion, Morgane; Lokmane, Ludmilla; Garel, Sonia

91

The role of stathmins in the intracellular signaling pathways of axon guidance in the oculomotor systemGudjonsdottir, Ragnheidur; Carretero, Luis; Hafezparast, Majid; Guthrie, Sarah

92

The role of teneurin-4 in shaping morphological and functional connectivity of retinal ganglion cells in zebrafishSzydlo Shein, Andrea; Trevers, Katherine; Hindges, Robert

93

The spliceosomal protein SNRNP70 co-localizes with RNA in axons and regulates neuromuscular assemblyNikolaou, Nikolas; Gordon, Patricia; Houart, Corinne

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“Circuits Development & Axon Regeneration” - 3rd AXON Meeting • 21Poster Sessions

94

Transcription factor LHX2 is required in early cortical progenitors for normal thalamocortical innervationPal, Suranjana; Pramanik, Tuli; Dwivedi, Deepanjali; Godbole, Geeta; Bhalla, Upinder S.; Tole, Shubha

95

Transcriptomic and genomic signatures of axon guidance decisionsFernández-Nogales, Marta; López-Cascales, María Teresa; Fernández-Albert, Jordi; Murcia-Belmonte, Verónica; Barco, Ángel; Herrera, Eloísa

96

Understanding the mechanisms involved in the migration and circuit integration of GABAergic thalamic interneuronsHuerga Gomez, Irene; Espinosa, Ana; López-Bendito, Guillermina

97

Unexpected Role of Imprinted Cdkn1c Genomic Locus in Cortical DevelopmentBeattie, Robert; Laukoter, Susanne; Pauler, Florian M.; Nakayama, Keiichi I.; Hippenmeyer, Simon

98

Unraveling the unexpected function of wild type and mutated RAD51 proteins in the development of the Corticospinal tract in miceFouquet, Coralie; Welniarz, Quentin; Morel, Marie-Pierre; Pourchet, Oriane; Trouillard, Oriane; Dubacq, Caroline; Doulazmi, Mohamed; Trembleau, Alain; Dusart, Isabelle; Roze, Emmanuel

99

Variable brain: Live-imaging of axonal branching pattern through development resulting in stereotypical adult circuitryDutta, Suchetana Bias; Hassan, Bassem; Heisinger, Peter Robin

100 A retino-retinal projection guided by Unc5c emerged in species with retinal wavesMurcia-Belmonte, Veronica; Coca, Yaiza; Vegar, Celia; Negueruela, Santiago; De Juan, Camino; Valiño, Arturo José; Sala, Salvador; Kania, Artur; Borrell, Victor; Martínez, Luis M; Erskine, Lynda; Herrera, Eloisa

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VenueMELIA ALICANTE HOTELPlaza del Puerto, 3 (Alicante)

Useful InformationTaxi Service: (+34) 965 101 611 or (+34) 965 252 511Technical Secretariat: +34 933 633 954

BusFrom airport: Line C6 has stop at Hotel MeliaFrom the city center: Line 21 and 02 have stop at Hotel Melia

Conference Rooms- Europa Room: Plenary room - Mediterraneo Room: Poster exhibition- Plaza Terrace: Coffee break- Postiguet: Lunch & dinner on Wednesday 11th

- Solarium: Lunch on Friday 13th

Gala DinnerOn Friday 13th, at 21.00pm - Santa Barbara CastleTo attend the Gala Dinner take the bus at the entrance of Melia Hotel (Venue):Departures at: 20.15pm, 20.20pm & 20.30 pm

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