ANTIMUTAGENS in food. FOOD Foods are comlex mixtures containing both carcinogenic and...
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Transcript of ANTIMUTAGENS in food. FOOD Foods are comlex mixtures containing both carcinogenic and...
FOOD
• Foods are comlex mixtures containing both carcinogenic and anticarcinogenic substances.
• It is our choice – HEALTHY x NOT HEALTHY• Prevention against cancer - ANTIMUTAGENS
Carcinogenesis
• Carcinogenesis: TWO STAGE PROCESs
a) Initiation b) Promotion • Inhibitors of mutagenesis = inhibitors
of carcinegenesis
Antimutagens
• REDUCE NUMBER OF MUTATIONS• Clasification: a) Desmutagens – they inactivate
mutagens b) Bioantimutagens – reduce effect
of mutagensAntioxidants „catch free radicals“
ASCORBIC ACID
• Water soluble• The strongest antioxidant in body• Cofactor of many enzymes• dopamin - andrenalin
VITAMIN E
• It contains 8 substances (90% -tokoferol).
• Fat soluble – inhibition of oxidation of unsaturated fatty acids.
• The richest natural source- plant oil
- Karotene
• Lipid soluble pigment• Enzymatically
hydrolyzed – Vitamin A• Antioxidant – fat
stores and lipid membranes
• Treatment of some genetic diseases
SULFIDES
• Diallyl sulfide, diallyl disulfide – garlic• React with nirosoamines• Reduce level of LDL cholesterol and
triacylgycerols
Glutathion
• Tripeptide• Reducing agent, soluble in cellular
plasmas• Defence against toxic compounds
(aflatoxin….)
Selenium
• Toxic x antimutagens, antioxidant• Mechanism not clearly defined,
depends on concetration• PRECISE (Prevention of Cancer
through Intervation with Selenium)
CATECHINS
• Up to 30% weight of dry tea
• 1. green tea, 2. white tea, 3. black tea
• The effect depends on preparation
What have I forgotten..?
• I know, that there many other antimutagens I haven´t talked about.
• Magnesium, Unsaturated fatty acids, glukosinates …etc. I hope they will excuse me..;-)