Antimicrobial resistance complex issue
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Transcript of Antimicrobial resistance complex issue
SHIV VARAN SINGH
VBM(M.V.Sc)
M-5547
ANTIMICROBIAL RESISTANT:A COMLPEX ISSUE
WHY RESISTANCE IS A CONCERN
• Resistant organisms lead to treatment failure
• Increased mortality
• Resistant bacteria may spread in Community
• Low level resistance can go undetected
• Added burden on healthcare costs
• Threatens to return to pre-antibiotic era
• Selection pressure
ANTIMICROBIAL RESISTANCE MECHANISM
Intrinsic (Natural) Acquired
Genetic Methods
Chromosomal Methods Mutations
Extra chromosomal Methods Plasmids
INTERACTION OF BACTERIAWITH ANTIBIOTICS
ORIGIN OF ANTIMICROBIALRESISTANCE DETERMINANTS
Animal pathogen
RESISTANCE TO ANANTIBIOTIC CAN BE ACQUIRED
SELECTION OF A RESISTANTBACTERIAL POPULATION
• PRE-EXISTING SELECTION(RESISTOME)
• MUTANT ONE SELECTED(SUBSISTOME)
• CONCENTRATION BASIS
DISSEMINATION OF BACTERIA
EDUCATIONAL ACTIVITIES TO PROMOTE APPROPRIATE USE OF ANTIMICROBIAL AGENTS IN ANIMAL HEALTH
• Veterinary Curriculum
• State-based Interventions
Strategy of ContainmentAntibiotic Resistance
Evolutionary Process
Faulty Use of Antibiotics
Hospital Environmental
Empirical Use Definitive Use
Community Acquired Antibiotic Resistance
Hospital Acquired Antibiotic Resistance
Use of antimicrobials before pathogen responsible for a particular illness or the susceptibility to a particular antimicrobial is known
HOW THE COMPLEXITYOF THE RESISTANCE PROBLEM DEDUCED
Do not use Faulty Antimicrobial Antimicrobial warranted or not
What are etiological agents? Definitive treatment
One OR In combination What can we do?