ANTIMICROBIAL AGENTS ANDCHEMOTHERAPY

VOLUME 25 * JUNE 1984 NUMBER 6

Leon H. Schmidt, Editor in Chief (1985)University ofAlabama in Birmingham

BirminghamHerbert L. Ennis, Editor (1987)

Roche Institute ofMolecular BiologyNutley, New Jersey

Robert L. Hamill, Editor (1985)Eli Lilly & Company, Inc.

Indianapolis, Indiana

George A. Jacoby, Jr., Editor (1985)Massachusetts General Hospital

BostonRobert C. Moellering, Jr., Editor (1987)New England Deaconess Hospital

Boston, Massachusetts

Peter G. Welling, Editor (1988)Warner-Lambert Co.Ann Arbor, Michigan

EDITORIAL BOARD

John A. Washington II, Editor (1986)Mayo Clinic

Rochester, Minnesota

Norris Allen (1986)Vincent T. Andriole (1984)John P. Anhalt (1984)Bascom F. Anthony (1985)George R. Aronoff (1986)Robert Austrian (1986)Richard H. Baltz (1984)Rashmi H. Barbhaiya (1986)Arthur L. Barry (1986)John D. Bartlett (1984)Michael Barza (1985)John E. Bennett (1984)Richard F. Bergstrom (1985)Gerald P. Bodey (1986)Lawrence E. Bryan (1985)Ward Bullock (1984)Tsun Chang (1986)Anthony Chow (1985)C. Glenn Cobbs (1986)Paul S. Cohen (1986)William A. Craig (1984)Naomi Datta (1984)Lawrence E. Day (1986)William E. Dismukes (1984)R. Gordon Douglas, Jr. (1986)John C. Drach (1984)Theodore Eickhoff (1985)Gertrude B. Elion (1984)Arthur English (1986)

Robert J. Fass (1985)Stuart Feldman (1985)Sydney Finegold (1985)Robert J. Fitzgerald (1986)Martin Forbes (1986)Dale N. Gerding (1985)David Gilbert (1984)Anthony J. Glazko (1984)Irving H. Goldberg (1985)Richard H. Gustafson (1984)Jack Gwaltney (1986)Scott M. Hammer (1986)W. Lee Hand (1986)H. Hunter Handsfield (1986)Maurice W. Harmon (1984)Joseph Hawkins, Jr. (1985)Michael Higgins (1986)Richard Hornick (1986)George Gee Jackson (1986)James H. Jorgensen (1984)William J. Jusko (1986)A. W. Karchmer (1985)Donald Kaye (1985)George S. Kobayashi (1985)Donald J. Krogstad (1986)Felix Leitner (1986)Stephen A. Lerner (1986)Matthew E. Levison (1984)

Stuart B. Levy (1986)Friedrich C. Luft (1984)Joan Lusk (1986)R. Luthy (1986)Francis L. Macrina (1985)Gerald L. Mandell (1986)Gary R. Matzke (1986)George H. McCracken (1984)Gerald Medoff (1986)Michael Miller (1984)Barbara Minshew (1985)Bernard Moss (1984)Thomas P. Moyer (1986)Barbara E. Murray (1984)John D. Nelson (1986)Harold C. Neu (1986)James T. Park (1985)James E. Pennington (1986)T. J. Perun (1986)Lance R. Peterson (1985)Burton M. Pogell (1984)Michael Rein (1986)W. H. G. Richards (1986)Richard Roberts (1985)Ian M. Rollo (1985)Richard Root (1986)John P. Rosazza (1986)Jon E. Rosenblatt (1985)

Merle Sande (1985)Christine C. Sanders (1984)W. Eugene Sanders (1984)W. Michael Scheld (1986)Jerome J. Schentag (1985)Raymond F. Schinazi (1986)Fritz D. Schoenknecht (1986)F. C. Sciavolino (1985)William M. Shannon (1986)Charles Shipman, Jr. (1985)Robert W. Sidwell (1984)P. Frederick Sparling (1984)Harold Standiford (1985)David A. Stevens (1986)R. Sutherland (1985)Vera L. Sutter (1984)Morton N. Swartz (1985)Richard B. Sykes (1985)Francis P. Tally (1984)Alexander Tomasz (1985)Ralph Tompsett (1985)Francis L. S. Tse (1986)Michael Waring (1984)Bernard Weisbium (1985)Richard M. Welch (1986)Richard Wise (1986)Lowell Young (1985)Pauline K. W. Yu (1985)

Helen R. Whiteley, Chairman, Publications BoardLinda M. Illig, Managing Editor, Journals

Walter G. Peter III, Director of PublicationsDeborah J. Shuman, Production Editor

Antimicrobial Agents and Chemotherapy (ISSN 0066-4804), an interdisciplinary publication of the American Society for Microbiology,1913 I St., NW, Washington, DC 20006, is devoted to the dissemination of knowledge relating to all aspects of antimicrobial, antiparasitic, andanticancer agents and chemotherapy. Instructions to authors are published in the January issue each year; reprints are available from theeditors and the Publications Department. Antimicrobial Agents and Chemotherapy is published monthly, and the twelve numbers are dividedinto two volumes per year. The nonmember subscription price is $157 per year; single copies are $21. The member subscription price is $31(foreign, $41 [surface rate]) per year; single copies are $7. Correspondence relating to subscriptions, reprints, defective copies, availability ofback issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM PublicationsDepartment, 1913 I St., NW, Washington, DC 20006 (phone: 202 833-9680).Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication ofthe issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing becauseof failure to report an address change or for issues "missing from files" will not be allowed.Second-class postage paid at Washington, DC 20006, and at additional mailing offices.POSTMASTER: Send address changes to Antimicrobial Agents and Chemotherapy, ASM, 1913 I St.. NW, Washington, DC 20006.Made in the United States of America.Copyright © 1984, American Society for Microbiology. H*: 14ltS* ii e ;11wl* ( Fl4u.All Rights Reserved.The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may bemade for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the statedper-copy fee through the Copyright Clearance Center, Inc., 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, foradvertising or promotional purposes, for creating new collective works, or for resale.

Author Index

Ackerman, Bruce H., 785Actor, Paul, 694Apolloni, E., 760Arosio, E., 760

Baron, Ellen J., 781Barry, Arthur L., 710, 775Bayer, Arnold S., 725Bedows, Elliott, 719Benoni, G., 760Borowski, E., 772Bryan, L. E., 747

Campos, Jose, 706Catlin, B. Wesley, 676Chin, Nai-Xun, 687

Davidson, Bruce A., 719De Broe, Marc E., 783Devos, J., 764Dubreuil, L., 764Dunn, George L., 694

Eisenstadt, Rosalee, 725

Garcia-Tornel, Santiago, 706Giuliano, Ruben A., 783

Gotoh, Akira, 754Grappel, Sarah F., 694Grossman, Dena M., 690Guymon, L. F., 767

Hastie, Annette T., 673Higgins, Michael L., 673Hindler, Janet A., 781

Jakas, Dalia R., 694James, Philip R., 735Jenkin, H. M., 772Jones, Ronald N., 710, 775

King, John W., 770Knight, Paul R., 719Knight, Vernon, 729Kobasa, William D., 683Konno, Masatoshi, 754Kramer, Michael J., 729Kueppers, Friedrich, 673

Labthavikul, Pornpen, 687Lechi, A., 760Lentino, Joseph R., 778Levison, Matthew E., 683Lind, I., 767

Malewicz, B., 772Momsen, M., 772Morrison, Joan O., 725Myers, William F., 690

Neu, Harold C., 687Neut, C., 764

Parr, Thomas R., Jr., 747Parrillo, Patricia, 778Passarella, E., 760Penn, Robert L., 770Phillips, Lillian, 694Pitkin, Donald, 694Pollet, Dirk E., 783

Raimondi, M. G., 760Romond, C., 764Ross, Janette, 785Rotschafer, John C., 785

Sakuma, Takashi, 742Sanfeliu, Isabel, 706Scharpe, Simon L., 783Shafer, W. M., 767Sparling, P. F., 767

Stachowski, Michael, 778Strikas, Raymond, 778Sun, Chong-Son, 729

Tannenbaum, Charles S., 673Thornsberry, Clyde, 710Tofte, Robert W., 785

Ubukata, Kimiko, 754

Vaara, M., 701Velo, G. P., 760Verbist, Ludo, 783Verpooten, Gert A., 783Viljarten, P., 701Vosbeck, Klaus, 735

Weinbaum, George, 673Wilson, Samuel Z., 729Wisseman, Charles L., Jr., 690Wyde, Philip R., 729

Yamashita, Naoko, 754

Zimmermann, Willy, 735

AUTHOR INDEX

VOLUME 25

Ackerman, Bruce H., 785Ackers, Irene, 579Actor, P., 373Actor, Paul, 694Adejuyigbe, Olusanya, 497Adkinson, N. Franklin, Jr., 93Ahmed, S. Masud, 643Akhter, S. Q., 643Albritton, William L., 187, 296Alford, Robert H., 405Anderson, Burt, 296Andreana, Augusto, 182Andrews, J. M., 612Andritz, Mary H., 33Angehrn, Peter, 607Apolloni, E., 760Arbeter, A. M., 417Arceneaux, Jean E. L., 650Arcey, Sergio M., 16Arndt, Kenneth A., 553Aronoff, George R., 513Aronoff, Stephen C., 279Arosio, E., 760Asahi, Yoshinari, 131Ash, Ronald J., 443Assael, Baroukh M., 395Auerbach, Jeffrey I., 622Auger, Franqois, 662Austin, Thomas W., 455Ayers, L. W., 633Ayers, Leona W., 669Ayrton, John, 78Azegami, Masao, 146

Baba, Masanori, 515Baker-Zander, Sharon A., 390Ballard, James O., 153Baltch, Aldona L., 33, 488Bannatyne, Robert M., 537Barge, Janine, 168Barlam, Tamar, 529Barnes, Scott G., 153Baron, Ellen J., 781Baron, Jody L., 646Baron, Samuel, 646Barrueco, M., 458Barry, A. L., 633Barry, Arthur L., 392, 669, 71

775Bartus, Henry R., 622Barza, Michael, 655Baxter, Heather, 306Bayer, Arnold S., 725Beaulieu, Bernard B., Jr., 65Bedows, Elliott, 719Beggs, William H., 316Beight, Douglas W., 443Belsheim, Judy, 179Benoni, G., 760Berens, Randolph L., 292Berliner, Daniel, 7Berman, Steven J., 438Bianchi, P., 666Biddle, James, 296Bieth, Gilda, 289Blase, David K., 513Blevins, Roger D., 603Blok-Perkowska, Danuta, 134Blomqvist, Charlotte, 179Blumer, Jeffrey L., 579Bondi, Joseph V., 238

Bongaerts, Ger P. A., 234Borner, K., 105Borobio, M. Victoria, 342Borowski, E., 772Borsa, F., 638Bosso, John A., 630Boutwell, M. E., 650Bouzos, John, 534Bright, Gene M., 113Brion, Nils, 168Brook, Itzhak, 71Brown, Daniel R., 422Brown, Douglas, 286Brown, Timothy H., 405Brumfitt, W., 276Bryan, C. S., 37Bryan, L. E., 382, 747Buesing, Mary A., 283Butler, Thomas, 643Buu-Hoi, Annie, 289Byers, B. R., 650

Cabezudo, Ignacio, 4Cable, Douglas C., 258Campbell, Gwendolyn S., 205Campos, Jose, 706Campos, Joseph M., 327Carbon, Claude, 168, 618Cardinal, J. R., 10Carr, Douglas, 539Carter, Walker T., 162Casalino, M., 499Catlin, B. Wesley, 676Chan Lee, Huei, 146Chau, Nguyen Phong, 618Cheung, Rose, 537Chiemchanya, Surang, 273Chin, Nai-Xun, 319, 687Chopra, Ian, 446Chou, Sunwen, 25Cohn, Naomi K., 292Coleman, William G., Jr., 539Collins, Shirley H., 301Comanducci, A., 499Congeni, Blaise L., 40Conroy, Joseph V., 33Contrepois, Alain, 168, 618

10, Coolbaugh, James C., 71Coppenhaver, Dorian H., 646Correia, Ricardo A., 653Crooke, Stanley T., 622Crossley, Kent B., 532Crumpacker, Clyde S., 247, 553Culbert, Steve, 62

Daneshmend, Tawfique K., 1Davidson, Bruce A., 719Davies, Mary-Ellen M., 238Davis, Donald R., 20De Broe, Marc E., 783De Clercq, Erik, 566DeClercq, Erik, 515DeGirolami, P., 401Deneer, Harry G., 187Denoya, Claudio D., 659Devlin, Richard G., 358Devos, J., 764Dewsnup, Daniel H., 165Dilillo, Mariantonia, 182Diven, Warren, 473Dominguez-Gil, A., 458

Dotzlaf, Joe E., 216Dromer, Francoise, 168Dubois, Catherine, 168Dubreuil, L., 764Dunn, George L., 694Dworzack, David L., 494Dylewski, Joe S., 25

East, Donald S., 83Eby, George A., 20Echols, Roger M., 336Egbert, Peter R., 25Eisenstadt, Rosalee, 725Elion, Gertrude B., 507Eliopoulos, G. M., 331, 401Eliopoulos, George M., 398Elvers, A., 105Ene, Mokelu D., 1Eng, Robert H. K., 510English, A. R., 118English, Arthur R., 113, 226, 599Eppstein, Deborah A., 563

Fadl-Allah, Nora, 375Fainstein, V., 387Falkinham, Joseph O., III, 137Farber, Bruce F., 398Fasching, Claudine E., 58, 545,

596Fass, Robert J., 408Field, A. Kirk, 238, 247Fillastre, J. P., 638Finegold, Sydney M., 162Fischer, Philip R., 502Fite, Laurie D., 443Fliegelman, Robert M., 504Florioli, Alessandra, 395Flynn, Gary A., 443Foglesong, Mark A., 216Fontijne, P., 575Forbes, Betty A., 491Forthal, Donald N., 258Fortin, Louise, 83Fourtillan, Jean-Bernard, 618Frankel, Lawrence S., 62Fraser-Smith, Elizabeth B., 563Freydiere, A. M., 144Frongillo, R. F., 666Fuchs, Peter C., 392Funk, Mary L., 301Furman, Phillip A., 191, 507

Gangemi, J. D., 37Garcia-Tornel, Santiago, 706Gardella, A., 331, 401Gavan, Thomas L., 669Gaynon, Michael W., 25George, Karen L., 137George, W. Lance, 657Geratz, J. Dieter, 582Gerding, Dale N., 58, 545, 560Gerlach, E. H., 633, 669Gerv6s, M. Santiago, 458Giamarellou, Helen, 534Gill, Charles J., 327Gill, M. John, 476Gille, Y., 144Girard, A. E., 118Girard, Dennis, 599Giuliano, Ruben A., 783Givan, Katherine F., 455

Glasser, Lynne A., 510Glette, Johan, 354Gnarpe, H'akan, 179Godefroy, Isabelle, 168Godfrey, A. J., 382Goessens, Wil H. F., 575Goldman, Peter, 65Gombert, Myles E., 510Gooch, W. Manford, III, 502Goodman, Larry J., 504Gootz, Thomas D., 591Gordon, Y. Jerold, 522Goto, Sachiko, 98Gotoh, Akira, 754Goueffon, Y., 463Grappel, Sarah F., 694Greenman, Richard L., 16Griffin, Paul E., 33Gropen, Toby I., 522Grossman, Dena M., 690Gruft, Howard, 137Guay, David R., 306Guenthner, Sharon H., 4Guerrant, Richard L., 653Gutterman, Deborah A., 16Guymon, L. F., 767

Halcomb, William W., 20Hall, Dennis, 571Hall, Michael J., 607Haller, Ingo, 125Halstenson, C. E., 128Halstenson, Charles E., 433, 603Hamilton-Miller, J. M. T., 276Hammer, Mark C., 33Hansen, Alfred R., 301Hansen, Chad S., 301Hantz, O., 242Harcus, Jane L., 571Harding, Stuart M., 78, 344Harris, Betty, 162Harris, Cynthia, 560Harrison, Lester I., 301Hashizume, Terutaka, 148Haskell, Suzanne L., 599Hastie, Annette T., 673Hayden, Frederick G., 53Hector, Richard F., 596Heessen, Frans W. A., 123Herbst, John J., 630Hersh, Evan M., 366Hewlett, Erik L., 571Higgins, Michael L., 673Hindler, Janet A., 781Hirata, Takahiro, 148, 348Hoeprich, Paul D., 339Holmes, King K., 390Hooper, David C., 586Hopen, Gunnar, 354Hopfer, R. L., 387Hopfer, Roy L., 366Horaud, Thea, 289Hughes, Carolyn E., 560, 596Humbert, G., 638Hunaiti, Abdelrahim A., 173

Ikeda, Chieko, 221Inaba, Hitoshi, 88Inoue, Hiroshi, 146Inoue, Matsuhisa, 362

i

ANTIMICROB. AGENTS CHEMOTHER.

Isono, Midori, 131Ito, Masahiko, 515

Jackson, David B., 591Jacobs, Michael R., 527Jacoby, Irving, 626Jacyk, William R., 306Jakas, Dalia R., 694James, Philip R., 735Jenkin, H. M., 772Johnson, Elizabeth M., 1Johnson, Jonas, 473Johnson, Randall K., 622Johnson, Steven R., 296Johnston, Ralph W., 205Jones, R. N., 633Jones, Ronald N., 392, 669, 710,

775Jordan, A. B., 37Jorgensen, James H., 283Juliano, R. L., 387Juliano, Rudolph L., 366

Kabir, Iqbal, 643Kamimura, Toshiaki, 98Kanzaki, Masako, 385Kaplan, Raymond L., 504Katz, Ehud, 195Katz, W., 253Keane, W. F., 128Keane, William F., 433Kern, Earl R., 553Kesado, Tadataka, 131Kim, H., 45King, John W., 770Kingsbury, W. D., 373Kirkpatrick, James, 7Klein, Robert S., 292Klinger, Jeffrey D., 279Knaus, Edward E., 476Knight, Paul R., 719Knight, Vernon, 729Kobasa, William D., 683Koeppe, P., 105Kojo, Hitoshi, 98Kolattukudy, Pappachan E., 173Konno, Masatoshi, 754Konopi6iska, Danuta, 134Kosuzume, Hiroshi, 88Koyama, Masaru, 221Kramer, Michael J., 729Kramer, William G., 62Kreeft, John H., 83Kueppers, Friedrich, 673Kunz, Samuel, 311Kuroki, Tohru, 146Kuwahara, Shogo, 98

Kwan, S., 382

Labthavikul, Pornpen, 687Lacroix, Jean-Michel, 662Lambe, Catherine U., 191Lamothe, Francois, 662Larsson, A., 524Lastra, C. Fernandez, 458Lawee, David, 455Lechi, A., 760Lefler, Eli, 450Leguy, F., 638Leive, Loretta, 539Lentino, Joseph R., 778Leroy, A., 638Levi, Joe U., 358Levison, Matthew E., 683

Lewis, John C., 380Lewis, Michael R., 422Li, Edwin L. F., 455Lin, C., 45Lind, I., 767Lipsky, James J., 380Livelli, Thomas J., 247Livermore, David M., 268Lloyd, William J., 607Lode, H., 105Lolekha, Somsak, 273Lopez-Berestein, G., 387Lopez-Berestein, Gabriel, 366Lorian, Victor, 311Lowy, Franklin D., 375Luft, Friedrich C., 513Lukehart, Shelia A., 390Lundback, Annika, 179Lynch, J. E., 118Lyon, James, 473

Maclean, Ian W., 187Mader, Jon T., 139Mageau, Richard P., 205Maimone, F., 499Malewicz, B., 772Mandel, Neil, 109Manian, Albert A., 571Margalith, Eva., 195Marifno, E. L., 458Marino, John, 527Marks, Melvin I., 212Marlowe, Steve, 553Marr, J. Joseph, 292Marsh, Y. Vivienne, 563Martin, Albert R., 626Martinez, Octavio V., 358Maruyama, Tsutomu, 385Maskell, Jeffrey P., 268Matsen, John M., 630Matsui, Hidefumi, 221Matsumoto, Yoshimi, 98Matthews, Thomas R., 563Mattie, H., 263Matzke, G. R., 128Matzke, Gary R., 433, 603McAnally, Thomas P., 422McClatchey, Kenneth D., 491McCormick, Ellen M., 336McCracken, George H., Jr., 2

427, 556McFarland, James W., 226McGory, Robert W., 433McGuirt, Paul V., 507McHugh, Gail L., 586McKeough, M. B., 10McKerlie, M. Louese, 646McLafferty, Martha A., 65Meatherall, Robert C., 306Meddens, M. J. M., 263Mehta, Kapil, 366Mehta, R., 387Mehta, Reeta, 366Mehta, R. J., 373Merigan, Thomas C., 25Merry, Joanne M., 339Meshnick, Steven R., 286Metzger, Linda S., 216Michel, M. F., 575Miller, Heather, 411Miller, Richard L., 191Miller, Wayne H., 191Mills, K., 387Mine, Yasuhiro, 98

Mirabelli, Christopher K., 622Mitsuhashi, Susumu, 362Miyakawa, Isao, 146Mobley, Harry L. T., 157Mochizuki, Hidenori, 88Moellering, R. C., Jr., 331, 401Moellering, Robert C., Jr., 398Molendijk, Lucy, 234Momsen, M., 772Montay, G., 463Moody, Julia A., 545, 560Moretti, A., 666Morgan, S. L., 37Morgant, Catherine, 618Mori, Norimasa, 146Morrison, Joan O., 725Muder, Robert R., 473Muller, G., 281Muramatsu, Masatake, 385Murray, Barbara E., 398Murray, Patrick R., 368Muytjens, Harry L., 123Muzalewski, Feliks, 134Myers, Carolyn M., 579Myers, William F., 690

Nagel, Arthur A., 113Nakagawa, Keiichi, 221Nakatsuru, Naoki, 221Nelson, Donald J., 292Nelson, Erica, 522Nesburn, Anthony B., 522Neu, Harold C., 319, 529, 687Neut, C., 764Nguyen, Khoi B., 455Nicoletti, M., 9Nierste, David M., 513Niles, Ann C., 368Noguchi, Takashi, 221Northrop, Dexter B., 479Novick, William J., Jr., 380

Ober, Robert E., 301Odio, Carla, 427, 556Ogilvie, Richard I., 83Ohmae, Kenichi, 385Ohnishi, Haruo, 88Okafor, Josephine I., 413

9 Olsen, Kurt D., 29Ooka, T., 242Opal, Stephen, 7Otto, Michael J., 566Overall, James C., Jr., 553Overturf, Gary D., 258

Panosian, Claire B., 655Parker, Bruce C., 137Parr, Thomas R., Jr., 747Parrillo, Patricia, 778Passarella, E., 760Pasticci, M. B., 666Patel, Indravadan H., 438Pattison, Fred L. M., 455Pattyn, Stefaan R., 518Pauluzzi, S., 666Pearson, Richard D., 571Penn, Robert L., 770Penner, Brian, 306Pennington, James E., 49Perea, Evelio J., 342Perna, Pasquale, 182Perry, Helen C., 247Peters, Andre C. B., 522

Peterson, Lance R., 58, 545, 560,5%

Pfaller, Michael A., 368Phillips, Lillian, 694Pichoud, C., 242Pickering, Larry K., 62Pirie, Donald K., 226Pitkin, Donald, 694Piziak, Myron V., 7Plotkin, S. A., 417Pohlod, Donald J., 377Pollack, Simeon, 375Pollet, Dirk E., 783Porter, F. D., 157Portnoy, David, 455Potten, Michael R., 1Preblud, S. R., 417Preblud, Stephen R., 327Proctor, E. A., 417Provoost, Abraham P., 497Prusoff, William H., 566Pugsley, Mary P., 494Pushkarskaya, Nina L., 53

Radika, Kesavan, 479Rahaman, M. Mujibur, 643Raimondi, M. G., 760Rector, Tim M., 582Reed, Michael D., 579Retsema J. A., 118Retsema, James A., 113, 226Richardson, Malcolm D., 1Ripa, S., 666Rohlfing, Stephen R., 301Romanowski, Barbara, 455Romaru, Annette, 618Romond, C., 764Ronald, Allan R., 187Roquet, F., 463Rosano, Thomas G., 336Rosen, Barry P., 157Rosenberg, Martin, 622Ross, Janette, 785Rotschafer, John C., 785Rubin, Robert H., 626Ruggiero, Giuseppe, 182Rusconi, Franca, 395Ryder, Neil S., 483

Sabados, Joyce, 646Saino, Yushi, 362Sakata, Yasutaka, 29Sakuma, Takashi, 742Salem, Nanda G., 603Samuel, John, 476Sandberg, Sverre, 354Sanders, Christine C., 494Sanders, W. Eugene, Jr., 494Sanfeliu, Isabel, 706Saravolatz, Louis D., 377Sattler, Fred R., 153Sawada, Takuo, 385Sawai, Tetsuo, 148, 348Saxon, Barbara A., 630Schaberg, Dennis R., 491Scharpe, Simon L., 783Schelkly, W., 118Schentag, Jerome J., 201Schiff, Jill B., 49Schlepushkin, Anatoli N., 53Schnipper, Lowell E., 553Schultz, Robert W., 201Schuppan, Dietrich, 301Schuster, F. L., 109

ii AUTHORINDEX

AUTHOR INDEX iii

Schwab, Bernard, 205Sciavolino, Frank C., 113Scribner, Ronald K., 212Seidl, Gunther, 483Selden, Robert F., 4Seto, Kenji, 385Shafer, W. M., 767Shatzman, Allan R., 622Shaw, James E., 507Sherris, John C., 591Shields, David S., 653Shigeta, Shiro, 515Shikuma, Cecilia, 258Shipley, Patricia L., 653Shlaes, David M., 527Siegel, Scott A., 566Siemsen, A. W., 438Silver, Simon, 157Sirinavin, Sayomporn, 273Slaney, Leslie A., 187Smith, C. W., 37Smith, Gaylord, 286Smith, Margaret C. M., 446Smith, Raymond P., 33, 488Sobel, J. D., 281Solberg, Claus O., 354Solliday, JoAnne, 532Somerville, Peter J., 83Sommers, De Klerk, 344Sommers, H. M., 633Sommers, Herbert M., 669Southern, J. A., 253Sparling, P. F., 767Spencer, G. R., 638Spruance, S. L., 10Spruance, Spotswood L., 553St. Clair, Marty H., 191Stachowski, Michael, 778Starr, S. E., 417Steigbigel, Neal H., 375Stern, Robert C., 579

Stevens, David A., 450Storrs, Bruce, 502Strikas, Raymond, 778Stutman, Harris R., 212Sugerman, A. Arthur, 93Sugihara, J. G., 438Sun, Chong-Son, 729Sutphen, Nancy, 33Sutton, J. P., 37Swabb, Edward A., 93Swartz, Mark D., 586Swartz, Morton N., 586Szoka, Francis, 655

Tagari, Gioula, 534Takafuji, Ernest, 7Takahashi, Toshio, 385Tannenbaum, Charles S., 673Tao, Pei-Zhen, 524Taylor, Dean P., 622Telesetsky, Stephanie, 539Terakado, Nobuyuki, 385TeStrake, Diane, 413Thearle, Patricia, 473Thomas, Marion L., 29, 427,Thompson, J., 263Thompson, Robert L., 4Thornsberry, C., 633Thornsberry, Clyde, 392, 710Threlkeld, Norma, 556Ti, Teow-Yee, 83Tidwell, Richard R., 582Tiemens, Karen M., 653Tigaud, S., 144Tocci, Michael J., 247Tofte, Robert W., 532, 785Tolkoff-Rubin, Nina E., 626Tramont, Edmund, 7Trenholme, Gordon M., 504Trepo, C., 242Trevisan, Alejandro R., 659

Troke, Peter F., 483Trousdale, Melvin D., 522Tuazon, Carmelita U., 411Tung, Charlotte, 586Tyrrell, D. Lorne, 476

Ubukata, Kimiko, 754Ueno, Kazue, 131Utili, Riccardo, 182

Vaara, M., 701Valenta, J., 373Van Caekenberghe, Dirk L., 518Van Etta, Linda L., 58van Furth, R., 263Van Leeuwen, Willem B., 497van Raffe, M., 575Van Schalkwijk, Wim P., 497Van Wyk, Marieta, 344Vaxelaire, Juliane, 311Velo, G. P., 760Verbist, Ludo, 141, 783Verhaegen, Jan, 141Verpooten, Gert A., 783

556 Viljanen, P., 701Vincent, P., 144Visscher, David W., 513Visudhipan, Pongsakdi, 273Vitvitski, L., 242Vosbeck, Klaus, 735

Wagenvoort, Johan H. T., 497Walker, David H., 582Walker, Marion L., 502Walker, Naomi A., 513Walker, Richard I., 71Warnock, David W., 1Watanabe, Kunitomo, 131Weinbaum, George, 673Weinfeld, R. E., 438Weiss, Emilio, 71

Welage, Lynda S., 201Welch, David F., 212Wennersten, Christine, 398Wenzel, Richard P., 4Westmacott, Donald, 607Wexler, Hannah, 162Wiebe, Leonard I., 476Williams, J. David, 268Williams, Peter E. O., 78, 344Williamson, Peter J., 1Wilson, Katharine J., 139Wilson, Mary E., 626Wilson, Samuel Z., 729Wise, R., 612Wisseman, Charles L., Jr., 690Wolfson, John S., 586Wong, E. G. C., 438Woodbury, Charles, 7Woods, D. R., 253Wright, Charlotte A., 408Wright, Donald N., 165Wu, David H., 488Wyde, Philip R., 729Wyler, David J., 655

Yamaguchi, Akihito, 148, 348Yamashita, Naoko, 754Yamashita, Toyoko S., 579Yangco, Bienvenido G., 413Yano, Kuniichiro, 221Yeung, Tin-Chuen, 65Yoshinaga, Koji, 221Yu, Victor L., 473

Zaffaroni, Giuseppe, 395Zak, Oto, 311Zimmermann, Willy, 735Zissis, Nicholas P., 534Zorz6pulos, Jorge, 659Zuromskis, Peter, 626Zweig, Richard M., 16

VOL. 25, 1984

SUBJECT INDEX

VOLUME 25

AC-1370mechanism of action, 88phagocyte functions, 88

Acanthamoeba spp.phenothiazone compounds, 109

Acridine orangeK. pneumoniae R plasmid deletion, 659

Acyclic nucleosides9-(1,3-dihydroxy-2-propoxymethyl)

guanine, 563Acyclovir

antiviral-activity potentiationpolyene macrolides, 772

efficacy, 10herpes simplex virus, 10DNA fragment synthesis, 507patient-initiated treatment, 553

penetration, 10synergy with interferon, 515topical therapy, 10varicella-zoster virus, 515

Adenine arabinosidesynergy with interferon, 515varicella-zoster virus, 515

Aerobic bacteriaerythromycin, 529RU 28965, 529

Amikacincombinations

ceftazidime, 725ceftizoxime, 725ceftriaxone, 725cystic fibrosis, 279P. aeruginosa, 279P. cepacia, 279

Enterobacteriaceae, 725nephrotoxicity, 168neutropenic-site rabbit model, 545P. aeruginosa, 545tubular reabsorption, 168

Aminoglycosidescombinations

teichomycin, 411vancomycin, 411

enterococci, 411extraction from renal cortical tissue, 783modification by enzymes

S. aureus, 754S. epidermidis, 754

nephrotoxicity, 1682"-O-nucleotidyltransferase activity, 234P. aeruginosa, 488, 534rat tissueenzyme immunoassays, 497

resistance, 234staphylococci, 411synergy with 13-lactams, 534tubular reabsorption, 168

Amoxicillincombined with clavulanic acid, 276urinary tract infections, 276, 626

Amphotericin Bantifungal activity, 387Aspergillus spp., 560C. albicans infection, 366combinations

antifungal agents, 560rifampin, 560

leishmaniasis, 655liposome encapsulated, 366, 387, 655prophylaxis, 366

Ampicillincombinationsgentamicin, 408

comparative efficacypivmecillinam, 643

S. faecalis endocarditis, 408shigellosis, 643

Anaerobic bacteriaapalcillin, 162cefoxitin, 764cefpiramide, 162ciprofloxacin, 342clindamycin, 764erythromycin, 529metronidazole, 764RU 28965, 529

Animal viruseshalothane, 719replication, 719

Antifungal agentsAspergillus spp., 560combinations

amphotericin B, 560rifampin, 560

Antifungal azolesBay 1 9139, 339Bay n 7133, 339

Antineoplastic agentsscreening

E. coli genetically modified strain, 622Antiviral compounds

varicella-zoster virus susceptibility, 417Apalcillin

anaerobes, 162comparative activity, 162

carbenicillin, 669piperacillin, 669

pharmacokineticscompared with piperacillin, 105

1-,-D-Arabinofuranosyl-E-5-(2-bromovin-yl)uracil

varicella-zoster virus, 742Arsenate

E. coli R factors, 157Aspergillus spp.

amphotericin B, 560antifungal agents, 560rifampin, 560

Azlocillincomparative efficacy, 49neutropenic-site rabbit model, 545P. aeruginosa

drug combinations, 545pneumonia, 49

pharmacokineticscystic fibrosis, 630

Aztreonamactivity

alone, 212in combination, 212

biliary tract disease, 358combinations

amikacin, 279cystic fibrosis, 279gram-negative bacilli, 2833-lactams, 283

multiple resistance, 283P. aeruginosa, 279P. cepacia, 279

comparative efficacy, 49excretion, 358

immunology, 93P. aeruginosa pneumonia, 49pediatric patients, 212syphilis, 390

Bacillus megateriumcopper toxicity, 650siderophores, 650

Bacitracincoagulase-negative staphylococci, 502S. aureus nasal carriers, 422

Bacterial infectionscefmenoxime, 510

BacteriocinsB. fragilis, 253

Bacteroides fragilisbacteriocins, 253cephalosporins7a-methoxy, 1317p-methoxyiminoacetamido, 131

clavulanic acid, 662P-lactams, 662synergy with gentamicin

clindamycin, 71metronidazole, 71penicillin, 71

Bacteroides melaninogenicussynergy with gentamicin

clindamycin, 71metronidazole, 71penicillin, 71

Basidiobolus spp.susceptibility, 413

Bay 1 9139antifungal activity, 339

Bay n 7133antifungal activity, 339high-pressure liquid chromatography,

596Bay o 9867

see ciprofloxacinBenzylpenicillinprobenecid interaction, 676

Biliary tract diseaseaztreonam excretion, 358

Biophotometric methodsS. aureus intraphagocytic activity, 735

Bordetella pertussisdegraded strains, 537resistance, 537

Bromovinyl deoxyuridinesynergy with interferon, 515varicella-zoster virus, 515

(E)-5-(2-Bromovinyl)-2'-deoxyuridineherpes simplex virus polypeptide syn-

thesis, 566BW7S9UDNA polymerases

cellular a, 191herpes simplex virus induced, 191

triphosphate, 191

Campylobacter fetus subsp. jejunimetronidazole, 145niridazole, 145

Campylobacter spp.ciprofloxacin, 504

Candida albicansamphotericin B, 366

iv

SUBJECT INDEX v

clotrimazole, 450econazole, 450growth, 483ketoconazole, 281, 450miconazole, 450naftifine, 483neutropenic mice, 366sterol biosynthesis, 483susceptibilitygrowth phase, 316ketoconazole, 316miconazole, 316

tioconazole, 450vaginitis, 281

Candida spp.peptide transport, 373polyoxin, 373

Carbapenem derivativesSF2103A, 348

Carbenicillincomparative activity

apalcillin, 669piperacillin, 669

hemostasis, 153Cardiopulmonary bypass surgery

ceftriaxone levels, 37Cefamandole

cross-resistancemethicillin, 666

E. colikilling, 182phagocytosis, 182

Cefazolinurinary excretion

furosemide, 618piretanide, 618water loading, 618

Cefmenoximeserious bacterial infections, 510

Cefoperazonepenetration into surgical-wound drain-

age, 473Ceforanide

S. aureus endocarditis, 16Cefotaxime

kineticseffects of protein binding, 58

susceptibility, 377Cefotiam

comparative efficacycephalothin, 778

dihydrochlorideplacental transfer, 147

skin infections, 778soft tissue infections, 778

Cefoxitinanaerobic bacteria, 764comparative activity

clindamycin, 764metronidazole, 764

neutropenic-site rabbit model, 545P. aeruginosa, 545

Cefpiramideanaerobes, 162comparative activity, 162pharmacokineticshumans, 221

Cefsulodincystic fibrosis, 4P. aeruginosa mutants, 382pharmacokinetics

cystic fibrosis, 579single dose, 579

Ceftazidimecombinations

amikacin, 725clindamycin, 657gentamicin, 725

distribution in ascitic fluid, 760Enterobacteriaceae, 725H. influenzae, 29meningitis

efficacy, 29pharmacokinetics, 29

nephrotoxicity in rats, 513P. aeruginosa mutants, 382pharmacokinetics

decreased renal function, 785meningitis, 29normal subjects, 638renal insufficiency, 201uremic subjects, 638

Pseudomonas spp., 395urinary tract infections, 395

Ceftizoximecombinations

amikacin, 725gentamicin, 725, 770

Enterobacteriaceae, 725high-pressure liquid chromatography,

336meningitis, 258neutropenic-site rabbit model, 545P. aeruginosa, 545, 770uremic patients, 336

Ceftriaxoneamikacin, 725combinations

gentamicin, 725Enterobacteriaceae, 725H. influenzae, 29kinetic disposition

renal failure patients, 83levels in blood and tissuecardiopulmonary bypass surgery, 37

meningitisefficacy, 29, 40

pharmacokineticsmeningitis, 29renal impairment, 438

Cefuroxime1-acetoxyethyl ester, 78axetil

pharmacokinetics, 344meningitis, 273

CephalosporinasesP. maltophilia, 362

Cephalosporinsaminothiazolyl a-methoxyimino, 710B. fragilis, 131cross-resistance

cefamandole, 666methicillin, 666

expanded spectrumSK&F 88070, 694

HR810, 7107a-methoxy, 1317p-methoxyiminoacetamido, 131resistance

Citrobacter spp., 591Cephalothincomparative efficacy

cefotiam, 778Enterobacteriaceae resistance, 725skin infections, 778soft tissue infections, 778

CephemsFK 027, 98

ChancroidH. ducreyi, 187tetracycline resistance, 187

Chlamydia trachomatiscinoxacin, 123ciprofloxacin, 123nalidixic acid, 123norfloxacin, 123pipemidic acid, 123

Chloramphenicolantagonism of 3-lactams, 405comparative activity, 327detection, 205enzyme-linked immunoassay, 205K. pneumoniae, 405quantitation, 205Salmonella spp., 327

Chlorpromazinehydrochloride

pathogenic amoebae, 109L. donovani, 571

Cinoxacinantibacterial activity, 633cross-resistance

DJ6783, 775enoxacin, 775nalidixic acid, 775norfloxacin, 775oxolinic acid, 775

C. trachomatis, 123resistant-population selection, 775

Ciprofloxacinanaerobic bacteria, 342antibacterial activity, 633Campylobacter spp., 504comparative activity, 319, 331, 518C. trachomatis, 123enteric pathogens, 504inoculum effect, 342medium effect, 342pH effect, 342

Citrobacter spp.cephalosporin resistance, 591

Clavulanic acidcombined with amoxicillin

urinary tract infections, 276combined with ticarcillin, 392,-lactam activity, 662

Clindamycinanaerobic bacteria, 764combined with ceftazidime

antibacterial activity, 657comparative activity

cefoxitin, 764synergyBacteroides spp., 71gentamicin, 71

ClotrimazoleC. albicans, 450

Cloxacillinstaphylococcal endocarditis, 311

Common coldzinc gluconate, 20

Conidiobolus spp.susceptibility, 413

Contact-blocking virus inhibitorsize, 646stability, 646

CopperB. megaterium, 560toxicity

VOL. 25, 1984

ANTIMICROB. AGENTS CHEMOTHER.

siderophores, 560Coumermycin

antibacterial activity, 687Cystic fibrosis

amikacin, 279azlocillin pharmacokinetics, 630aztreonam, 279cefsulodin

pharmacokinetics, 579sodium, 4

P. aeruginosa, 279P. cepacia, 279piperacillin, 279ticarcillin, 279

Cytomegalovirusa-interferon, 252'-nor-2'-deoxyguanosine, 247retinitis, 25

Desferrioxamineurinary tract isolates, 375

cis-Diammineplatinum[II]-polyglutamicacid

T. congolense, 286Dibekacin

nephrotoxicity, 168tubular reabsorption, 168

9-(1,3-Dihydroxy-2-propoxymethyl)guanine

herpes simplex virus, 563,-interferon, 563

DJ6783cross-resistance

cinoxacin, 775enoxacin, 775nalidixic acid, 775norfloxacin, 775oxolinic acid, 775

resistant-population selection, 775DNA gyrase inhibitors

E. coli plasmid elimination, 586DNA polymerasesBW759U triphosphate, 191cellular a, 191hepatitis virus, 242herpes simplex virus induced, 191

Doxycyclinepolymorphonuclear leukocytes, 354

EconazoleC. albicans, 450

Endocarditisampicillin, 408ceforanide, 16cloxacillin, 311drug abusers, 16gentamicin, 408granulocytes, 263mezlocillin, 408S. aureus, 16S. faecalis, 408S. sanguis, 263staphylococcal, 311

Enoxacincross-resistance

cinoxacin, 775DJ6783, 775nalidixic acid, 775norfloxacin, 775oxolinic acid, 775

resistant-population selection, 775

Enteric pathogensciprofloxacin, 504

Enterobacter aerogenesendocarditis

gentamicin, 683mezlocillin, 683ticarcillin, 683

EnterobacteriaP-lactamases, 268

Enterobacteriaceaeamikacin, 725ceftazidime, 725ceftizoxime, 725ceftriaxone, 725cephalothin resistant, 725gentamicin, 725

Enterococciaminoglycosides, 411ribosomal resistance, 398rifampin, 411streptomycin, 398susceptibility, 532teichomycin, 411vancomycin, 411

Enzyme immunoassaysaminoglycosides

rat tissue, 497Enzyme-linked immunoassays

competitivechloramphenicol, 205

Enzymesaminoglycoside modification, 754S. aureus, 754S. epidermidis, 754

Erysipelasswine

E. rhusiopathiae resistance, 385Erysipelothrix rhusiopathiae

chronic swine erysipelas, 385resistance, 385

Erythromycinaerobic bacteria, 529anaerobic bacteria, 529comparative activity, 529methylmalonyl-coenzyme A source, 173synthesis from S. erythreus, 173

Escherichia colicefamandole, 182DNA gyrase inhibitors, 586DNA repair mutants, 65genetically modified strain

antineoplastic-agent screening, 622gentamicin, 182killing, 182meningitis

mezlocillin pharmacokinetics, 427metronidazole, 65novobiocin, 586outer membrane permeability, 539phagocytosis, 182plasmid elimination, 586pMG110, 586R factors

arsenate, 157homology, 157

tetracyclines, 539tetracycline transport, 446

ExopolysaccharidesP. aeruginosa

binding, 673

FK 027antibacterial properties, 98

Fludalaninepentizidone combinationcomparative activity, 612

Flumequinefluorometric assays, 301high-pressure liquid chromatography,

301microbiological assays, 301

Fluorinated piperazinyl-substituted quino-line derivatives

comparative activity, 518Fluorometric assays

flumequine, 301Furosemide

cefazolin excretion in urine, 618

Gentamicincoagulase-negative staphylococci, 502combinations

ampicillin, 408ceftazidime, 725ceftizoxime, 725, 770ceftriaxone, 725mezlocillin, 408

E. colikilling, 182phagocytosis, 182

elimination rate, 128clearance, 128

Enterobacteriaceae, 725hemodialysis, 128nephrotoxicity, 168P. aeruginosa, 770synergy

B. fragilis, 71B. melaninogenicus, 71clindamycin, 71metronidazole, 71penicillin, 71

tubular reabsorption, 168Gonorrhea

rosoxacin, 455Gram-negative bacteria

aztreonam, 283,B-lactams, 283multiple resistance, 283polymyxin B nonapeptide, 701

GranulocytesS. sanguis endocarditis, 263stimulationimipenem, 179MK 0791, 179

Haemophilus ducreyichancroid treatment, 1871-lactamase plasmid, 296resistance

plasmid mediated, 187tetracycline, 187

Haemophilus influenzaemultiply resistant

susceptibility, 706type b

ceftazidime, 29ceftriaxone, 29chloramphenicol resistant, 29imipenem, 293-lactams, 747mechanisms of resistance, 747meningitis, 29

Halothaneanimal virus replication, 719

vi SUBJECT INDEX

SUBJECT INDEX vii

Heavy-metal saltssusceptibilityM. avium, 137M. intracellulare, 137M. scrofulaceum, 137

Hemodialysisgentamicin

clearance, 128elimination rate, 128

tobramycinclearance, 128elimination rate, 128

Hemostasiscarbenicillin, 153mezlocillin, 153placebo, 153

Hepatitis virusDNA polymerases, 242human, 242woodchuck, 242

Herpes labialisacyclovir, 553patient-initiated treatment, 553

Herpes simplex virusacyclovirDNA fragment synthesis, 507efficacy, 10penetration, 10topical therapy, 10

(E)-5-(2-bromovinyl)-Z'-deoxyuridine,566

BW759U triphosphate, 1919-(1,3-dihydroxy-2-propoxymethyl)

guanine, 563DNA polymerase induction, 191p-interferon, 563(E)-5-(2-iodovinyl)-2'-deoxyuridine up-

take, 476lithium

cell cultures, 522latent-infection reactivation in rab-

bits, 5222'-nor-2'-deoxyguanosine, 238orofacial infections in mice, 238polypeptide synthesis, 566SK&F 21681, 195thymidine kinaseguanosine analogs, 524

High-pressure liquid chromatographyBay n 7133, 596ceftizoxime, 336flumequine, 301Sch 28191 levels, 45

HR810evaluation, 710

Hypoprothrombinemia1-methyl-5-thiotetrazole, 380moxalactam, 380

ImidazolesC. albicans, 450clotrimazole, 450econazole, 450ketocanazole, 450miconazole, 450tioconazole, 450

Imipenembioactivitymedium, 781temperature, 781time, 781

granulocyte function stimulation, 179

H. influenzae, 29imipenem resistance, 491meningitis

efficacy, 29pharmacokinetics, 29

methicillin resistanceS. aureus, 491

P. vulgaris P-lactamase, 149subinhibitory concentrations, 491

Influenza virusinhibition

interferon, 53ribavirin, 53rimantadine hydrochloride, 53

Inosine analogsLeishmania spp., 292Trypanosoma spp., 292

Interferonaerosolized, 729clearance, 729cytomegalovirus retinitis, 259-(1,3-dihydroxy-2-propoxymethyl)

guanine, 563herpes simplex virus, 563human leukocyte, 515influenza virus inhibition, 53pulmonary deposition, 729synergy

acyclovir, 515adenine arabinoside, 515bromovinyl deoxyuridine, 515phosphonoformic acid, 515

Intraphagocytic activitybiophotometric method, 735S. aureus, 735

(E)-5-(2-Iodovinyl)-2 '-deoxyuridineherpes simplex virus, 476uptake, 476

Kanamycinacetyltransferaseenzymatic modification, 479resistance, 479VmaxlKm ratio, 479

KetoconazoleC. albicansgrowth phase, 316inhibition, 450killing, 450susceptibility, 316vaginitis, 281

pharmacokineticsinfluence of food, 1

Klebsiella pneumoniaechloramphenicol, 405P-lactams, 405R plasmids

acridine orange, 659deletions, 659

3-Lactamasesenterobacteria, 268H. ducreyi, 296inactivation, 348mezlocillin-resistant S. aureus

cell bound, 125extracellular, 125

N. gonorrhoeae, 296P. aeruginosa mutants, 382PSE-2, 268P. vulgaris

imipenem, 149

SF2103A, 348,-Lactamsantagonism by chloramphenicol, 405B. fragilis

clavulanic acid, 662combinations

aztreonam, 283gram-negative bacilli, 283multiple resistance, 283

H. influenzae type bmechanism of resistance, 747

K. pneumoniae, 405P. aeruginosa, 488, 534synergy with aminoglycosides, 534temocillin combinations, 142

Lankacidin group antibioticsside chain modifications, 226

Leishmania donovanichlorpromazine, 571

Leishmaniasisamphotericin B, 655

Leishmania spp.inosine analogs, 292

Listeria monocytogenesmeningitis

mezlocillin pharmacokinetics, 427Lithium

herpes simplex viruscell cultures, 522latent-infection reactivation in rab-

bits, 522

Meningitisceftazidime, 29ceftizoxime, 258ceftriaxone, 29, 40cefuroxime, 273E. coli, 427imipenem, 29L. monocytogenes, 427mezlocillin pharmacokinetics, 427traditional therapy, 40

Methicillincross-resistance

cefamandole, 666cephalosporins, 666

resistanceimipenem, 491S. aureqs, 491

Methylmalonyl-coenzyme Aerythromycin synthesis, 173S. erythreus, 173

1-Methyl-5-thiotetrazolehypoprothrombinemia, 380

Metronidazoleanaerobic bacteria, 764C. fetus subsp. jejuni, 145comparative activity

cefoxitin, 764E. coli DNA repair mutants, 65pharmacokinetics

peritoneal dialysis patients, 306synergyBacteroides spp., 71gentamicin, 71

Mezlocillincombinations

gentamicin, 408, 683E. aerogenes endq~zarditis, 683E. coli, 427hemostasis, 153

VOL. 25, 1984

ANTIMICROB. AGENTS CHEMOTHER.

L. monocytogenes, 427pharmacokinetics

meningitis, 427newborn infants, 556pediatric oncology patients, 62

S. aureus resistance,-lactamase, 125

S. faecalis endocarditis, 408Miconazole

C. albicansgrowth phase, 316inhibition, 450killing, 450susceptibility, 316

Microbiological assaysflumequine, 301

Minocyclinepolymorphonuclear leukocytes, 354

MK 0791granulocyte function stimulation, 179

Moxalactamhypoprothrombinemia, 380pharmacokinetics

elderly subjects, 33Mycobacterium avium

susceptibilityheavy-metal salts, 137oxyanions, 137

Mycobacterium intracellularesuspectibilityheavy-metal salts, 137oxyanions, 137

Mycobacterium scrofulaceumsusceptibility

heavy-metal salts, 137oxyanions, 137

Naegleria fowleriphenothiazone compounds, 109

NaftifineC. albicans, 483

Nalidixic acidantibacterial activity, 633cross-resistance

cinoxacin, 775DJ6783, 775enoxacin, 775norfloxacin, 775oxolinic acid, 775

C. trachomatis, 123resistant-population selection, 775

Neisseria gonorrhoeaeenvelope mutations

antibiotic susceptibility, 767env-10, 767pyocin resistance, 767

,B-lactamase plasmid, 2%probenecid, 676resistance trends, 7

Neisseria meningitidisnasopharyngeal carriers, 494Sch 29,482, 494

Nephrotoxicityaminoglycosides, 168tubular reabsorption, 168

Netilmicinnephrotoxicity, 168tubular reabsorption, 168

NiridazoleC. fetus subsp. jejuni, 145

Nocardia asteroidessusceptibility, 165

Nocardicin Asynergy

L-norvalyl-L-1-aminoethylphosphonicacid, 105

2'-Nor-2'-deoxyguanosinecytomegalovirus, 247herpes simplex virus, 238

Norfloxacinantibacterial activity, 633cross-resistance

cinoxacin, 775DJ6783, 775enoxacin, 775nalidixic acid, 775oxolinic acid, 775

C. trachomatis, 123resistant-population selection, 775

L-Norvalyl-L-1-aminoethylphosphonicacid

synergynocardicin A, 607

NovobiocinE. coli plasmid elimination, 586

2"-O-Nucleotidyltransferaseactivity-aminoglycoside resistance rela-

tion, 234

Oleandomycinderivatives

biological activity, 113, 118synthesis, 113

Osteomyelitisvancomycin

concentrations in rabbit serum, 140Oxacillin

coagulase-negative staphylococci, 502Oxolinic acid

antibacterial activity, 633cross-resistance

cinoxacin, 775DJ6783, 775enoxacin, 775nalidixic acid, 775norfloxacin, 775

resistant-population selection, 775Oxyanions

susceptibilityM. avium, 137M. intracellulare, 137M. scrofulaceum, 137

Oxytetracyclinepolymorphonuclear leukocytes, 354

Pediatric patientsaztreonam activity, 212

Pefloxacin mesylateabsorption, 463distribution, 463elimination, 463metabolic fate, 463

PenicillinsynergyBacteroides spp., 71gentamicin, 71

Pentizidonefludalanine combination

comparative activity, 612Pharmacokinetics

apalcillin, 105azlocillin, 607cefpiramide, 221cefsulodin, 579

ceftazidimedecreased renal function, 785H. influenzae meningitis, 29normal subjects, 638renal insufficiency, 201uremic subjects, 638

ceftriaxoneH. influenzae meningitis, 29renal impairment, 438

cefuroxime axetil, 344imipenem, 29ketoconazole, 1metronidazole, 306mezlocillin

meningitis, 427newborn infants, 556pediatric oncology patients, 62

moxalactam, 33piperacillin, 105sultamicillin, 599vancomycin

peritoneal dialysis, 603renal insufficiency, 433

Phenothiazone Fompoundschlorpromazine hydrochloride, 109inhibition of pathogenic amoebae, 109trifluoperazine dihydrochloride, 109

Phosphomycinpleural effusion patients, 458

Phosphonoformic acidsynergy with interferon, 515varicella-zoster virus, 515

Pipemidic acidC. trachomatis, 123

Piperacillincombinations

amikacin, 279cystic fibrosis, 279P. aeruginosa, 279P. cepacia, 279

comparative activityapalcillin, 669carbenicillin, 669

comparative efficacy, 49P. aeruginosa

mutants, 382pneumonia, 49

pharmacokineticscompared with apalcillin, 105

susceptibility, 377Piretanide

cefazoline excretion in humans, 618Pivmecillinamcomparative efficacy

ampicillin, 643shigellosis, 643

Placebohemostasis, 153

PlasmidsDNA gyrase inhibitors, 586E. coli(pMG110), 586novobiocin, 586resistance

acridine orange, 659deletions, 659host range, 289K. pneumoniae, 659streptococcal macrolide, 289

S. wien epidemic history, 499Pleural effusionphosphomycin, 458

Pneumoniaazlocillin, 49

viii SUBJECT INDEX

SUBJECT INDEX ixVOL. 25, 1984

aztreonam, 49P. aeruginosa, 49piperacillin, 49ticarcillin, 49tobramycin, 49

Polyene macrolidesacyclovir activity, 772

Polymorphonuclear leukocytesdoxycycline, 354minocycline, 354oxytetracycline, 354

Polymyxin B nonapeptidegram-negative bacteria, 701

Polyoxinanti-Candida activity, 373peptide transport, 373

Probenecidbenzylpenicillin interaction, 676N. gonorrhoeae, 676

Protease inhibitorsamidine type, 582R. rickettsii, 582

Protein bindingcefotaxime kinetics, 58

Proteus vulgaris1-lactamaseimipenem, 149

Pseudomonas aeruginosaamikacin, 279, 545aminoglycosides, 488, 534azlocillin, 49, 545aztreonam, 49, 279cefoxitin, 545cefsulodin, 382ceftazidime, 382ceftizoxime, 545, 770cystic fibrosis, 279exopolysaccharide

binding, 673gentamicin, 770P-lactamase, 382P-lactams, 488, 534mutants, 382neutropenic-site rabbit model, 545piperacillin, 49, 279, 382pneumonia, 49ticarcillin, 49, 279tobramycin, 49

Pseudomonas cepaciaamikacin, 279aztreonam, 279cystic fibrosis, 279piperacillin, 279ticarcillin, 279

Pseudomonas maltophiliacephalosporinase, 362

Pseudomonas spp.ceftazidime, 395urinary tract infections, 395

PyocinsN. gonorrhoeae resistance, 767

Quinolone carboxylic acid compoundsciprofloxacin, 319, 331

Renal enzyme inhibitorsMK 0791, 179

Renal insufficiencypharmacokinetics

ceftazidime, 201ceftriaxone, 438vancomycin, 433

ResistanceN. gonorrhoeae, 7

Retinitiscytomegalovirus, 25a-interferon, 25

R factorsE. coli

arsenate, 157homology, 157

Ribavirininfluenza virus inhibition, 53

Rickettsia rickettsiicell injury, 582protease inhibitors, 582

RifampinAspergillus spp., 560combinations

amphotericin B, 560antifungal agents, 560teichomycin, 411vancomycin, 411

enterococci, 411S. aureus nasal carriers, 422staphylococci, 411

Rimantadine hydrochlorideinfluenza virus inhibition, 53

Rochalimaea quintanasusceptibility patterns, 690trench fever, 690

Rosoxacingonorrhea, 455

RU 28965aerobic bacteria, 529anaerobic bacteria, 529comparative activity, 529

Salmonella spp.chloramphenicol, 327

Salmonella wienepidemic history, 499plasmid stability, 499

Sch 28191high-pressure liquid chromatography,

45levels in biological fluids, 45

Sch 29,482N. meningitidis nasopharyngeal carri-

ers, 494SF2103A

3-lactamase inactivation, 348Shigella flexneri

sulfamethoxazole-trimethoprim resist-ance, 653

Shigellosisampicillin, 643pivmecillinam, 643

SiderophoresB. megaterium, 560copper toxicity enhancement, 560

SK&F 21681herpes simplex virus, 191

SK&F 88070antimicrobial activity, 694

Skin infectionscefotiam, 778cephalothin, 778

SM-1652see cefpiramide

Soft tissue infectionscefotiam, 778cephalothin, 778

Sparsomycinnontoxic analogshydrophobic sulfoxide substituent,

443puromycin, 443

Staphylococciaminoglycosides, 411cloxacillin, 311coagulase negative

bacitracin, 502gentamicin, 502oxacillin, 502streptomycin, 502vancomycin, 502

endocarditis, 311rifampin, 411teichomycin, 411vancomycin, 411

Staphylococcus aureusaminoglycoside-modifying enzyme, 754biophotometric method, 735ceforanide, 16endocarditis, 16intraphagocytic activity, 735mezlocillin resistance

P-lactamase, 125nasal carriers

bacitracin, 422rifampin, 422

resistanceimipenem, 491methicillin, 491

tolerance detection, 571Staphylococcus epidermidis

aminoglycoside-modifying enzyme, 754Streptococci

resistance plasmids, 289Streptococcus faecalis

ampicillin, 408gentamicin, 408endocarditis, 408mezlocillin, 408

Streptococcus sanguisendocarditis, 263granulocytes, 263vancomycin resistance, 527

Streptomyces erythreuserythromycin synthesis, 173methylmalonyl-coenzyme A, 173

Streptomyces fradiaecarbon incorporation

tylactone, 216Streptomycin

coagulase-negative staphylococci, 502enterococci, 398ribosomal resistance, 398

Sulfamethoxazolecombined with trimethoprim, 653

Sulfamethoxazole-trimethoprimS. flexneri resistance, 653

Sultamicillinpharmacokinetics, 599

Surgical woundscefoperazone penetration, 473

Syphilisaztreonam, 390

Teichomycincombinations

aminoglycosides, 411rifampin, 411

enterococci, 411staphylococci, 411

ANTIMICROB. AGENTS CHEMOTHER.

Temocillincombined with other 3-lactams, 142

Tetracyclineschancroid treatment, 187doxycycline, 354E. coli outer membrane permeability,

539H. ducreyi resistance, 187hydrophobicity, 539minocycline, 354oxytetracycline, 354polymorphonuclear leukocytes, 354transport into E. coli, 446

Ticarcillincombinations

amikacin, 279clavulanic acid, 392cystic fibrosis, 279gentamicin, 683P. aeruginosa, 279P. cepacia, 279

comparative efficacy, 49E. aerogenes endocarditis, 683P. aeruginosa pneumonia, 49

TioconazoleC. albicans, 450

Tobramycinclearance, 128comparative efficacy, 49elimination rate, 128hemodialysis, 128P. aeruginosa pneumonia, 49susceptibility, 377

Trench feverR. quintana

susceptibility patterns, 690Trifluoperazine dihydrochloride

pathogenic amoebae, 109Trimethoprimcombined with sulfamethoxazole, 653

Trypanosoma congolensecis-diammineplatinum[II]-poly-glutam-

ic acid, 286Trypanosoma spp.

inosine analogs, 292Tuftsin

analogs, 134antibacterial properties, 134

Tylactonecarbon incorporationamino acid derived, 216S. fradiae, 216

U-63196Ecomparative activity, 401

Urinary tract infectionsamoxicillin, 626amoxicillin-clavulanic acid, 276ceftazidime, 395desferrioxamine, 375Pseudomonas spp., 395

VaginitisC. albicans, 281ketoconazole, 281

Vancomycincoagulase-negative staphylococci, 502combinations

aminoglycosides, 411rifampin, 411

enterococci, 411osteomyelitis

concentrations in rabbit serum, 140pharmacokinetics

peritoneal dialysis, 603renal insufficiency, 433

S. sanguis resistance, 527staphylococci, 411

Varicella-zoster virusacyclovir, 515adenine arabinoside, 5151-0-D-arabinofuranosyl-E-5-(2-bromo-

vinyl)uracil, 742bromovinyl deoxyuridine, 515interferon, 515phosphonoformic acid, 515susceptibility, 417

WIN 49375susceptibility, 377

Zinc gluconatecommon cold, 20double-blind study, 20

x SUBJECT INDEX

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