ANTICORPI RO52

Clinical significance of anti-Ro52 (TRIM21)

antibodies non-associated with anti-SSA

60!a antibodies" #es$lts of a %$lticent#ic

st$d&'

Ghillani P1, André C, Toly C, Rouquette AM, Bengoufa D,  Nicaise P, Goulestre C, Glei!es A,

Dragon"Durey MA, Alyana#ian MA, Chretien P, Chollet"Martin $, Musset %, &eill B, 'ohanet

C(

A$tho# info#%ation

Abst#act

Ro)* antigen has recently +een identified as TRM*1 -rotein, +ut the clinical significance of

anti"Ro)*.TRM*1 anti+odies re/ains controersial( The ai/ of this /ulticentric study 0as to

inestigate the significance of anti"Ro)* anti+odies 0ithout anti"$$A.Ro2 anti+odies in arious

connectie diseases( $era 0ere selected +y each la+oratory using its o0n /ethod 34%$A,i//unodot or %u/ine5 technology6, and then -erfor/ed 0ith ANA $creen BioPle57 reagent

3B8"RAD6( A/ong the *9: screened sera, 1)).*9: 3;<6 0ere confir/ed as anti"Ro)* -ositie

and anti"$$A.Ro2 negatie( These sera 0ere analy!ed for the detection of other anti+odies inrelation 0ith clinical settings( solated anti"Ro)* anti+odies 0ere detected in =>.1)) 3):<6 sera(

?or the re/aining sera 3.1))6, the /ain anti+odies associations 0ere $/.$/RNP or

Chro/atin 3n@;= ):<6, 'o1 3n@1: *<6 and Cen-B 3n@> 19<6( Clinical data fro/ the 1)) -atients sho0ed high -realence in autoi//une diseases 3:;<6 including /yositis or

der/ato/yositis 3n@;26, lu-us 3n@*;6 $gren and.or sicca syndro/e 3n@*:6 CR4$T or

$yste/ic sclerosis 3n@116 and autoi//une he-atitis 3n@116( &e found that -ul/onary

/anifestations 0ere often associated 0ith the -resence of anti"Ro)* anti+odies 3n@;9, **<6, inaddition 0ith anti"tRNA synthetases, anti"$RP or anti"u anti+odies 31=.;96 or isolated in half of 

cases 31.;96( $e-arate detection of anti"Ro)* anti+odies /ight +e useful in related

antisynthetase syndro/e diagnosis( The -resence of anti"Ro)* anti+odies should -ro+a+ly -recede deelo-/ent of autoi//une disease and /ust induce sequential follo0"u- of -ositie

 -atients, -articularly in interstitial lung disease -rogression(