Anticoagulant and Anti-Platelet Medications · 2020. 12. 14. · Thrombin and Platelet Thrombus...
Transcript of Anticoagulant and Anti-Platelet Medications · 2020. 12. 14. · Thrombin and Platelet Thrombus...
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Anticoagulant and Anti-Platelet Medications
Sayed E Wahezi, MDProgram Director, Pain Medicine Fellowship
Associate Professor of PMR, Anesthesiology, and Orthopedic Surgery
Montefiore Medical Center
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Disclosures
• Consultant• Boston Scientific
• PI• MOTION trial
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Outline
• Antiplatelets
• Anticoagulants
• Intrinsic and Extrinsic Coagulation Pathways
• Mechanism of Action of Pharmacotherapy
• Other considerations
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Antiplatelets
http://www.medicalestudy.com/pharma-antiplatelet-drugs-cheat-sheet/
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Anticoagulants
http://www.medicalestudy.com/anticoagulant-drugs-cheat-sheet/
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Thrombin and Platelet Thrombus Formation
Franchi F, Rollini F, Park Y, Angiolillo DJ. Platelet thrombin receptor antagonism with vorapaxar: pharmacology and clinical trial development. Future Cardiol. 2015;11(5):547-564. doi:10.2217/fca.15.50
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Antiplatelet Mechanism of Action
https://www.youtube.com/watch?v=ANXn3pUc9CA
https://www.researchgate.net/figure/Schematic-overview-of-new-antiplatelet-drugs-in-clinical-development-which-inhibit_fig1_257599204
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Anticoagulant Mechanism of Action
https://www.researchgate.net/figure/An-overview-of-mechanism-of-action-of-the-anticoagulant-drugs-showing-their-effects-on_fig2_267753112
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Anticoagulant Reversal
https://www.grepmed.com/images/7778/anticoagulation-criticalcare-pharmacology-medications-cardiology-comparison-hematology
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Other Considerations
https://www.researchgate.net/figure/Data-comparing-warfarin-with-new-anticoagulant-drugs_tbl1_230644934
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AC and Antiplatelet Recommendations for Pain Procedures
https://rapm.bmj.com/content/rapm/43/3/225.full.pdf
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Sayed E Wahezi, MD