Antibody Structure
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Antibody Structure
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Antibody Structure. B cell activation. Antibody-Mediated E ffector Functions. Antibody Classes. Immunoglobulin G ( IgG ) Most abundant class Four subclasses Activate complement system. Antibody Classes. Immunoglobulin M ( IgM ) Pentamer 1 st class produced in response - PowerPoint PPT Presentation
Transcript of Antibody Structure
Antibody Structure
B cell activation
Antibody-Mediated Effector Functions
Antibody ClassesImmunoglobulin G (IgG)
Most abundant class Four subclassesActivate complement system
Antibody ClassesImmunoglobulin M (IgM)
Pentamer1st class produced in responseto an antigenActivates complement system
Antibody ClassesImmunoglobulin A (IgA)
Predominant class in secretions Secretory IgA
Antibody ClassesImmunoglobulin E (IgE)
Hypersensitivity reactions
Antibody ClassesImmunoglobulin D (IgD)
Major membrane-bound immunoglobulin expressed by mature B cells.
Antigenic determinants on immunoglobulins
IsotypeAllotypeIdiotype
Humoral and Cellular Immunity
•Cellular immunity – Host defenses that are mediated by antigen-specific T cells and various nonspecific cells of the immune system.
•Humoral immunity – Host defenses that are mediated by antibody present in the plasma, lymph and tissue fluids.
