AntibioticsMarket2016

Thirty year void in antibiotics discovery

2

Percentage of Staphylococcus aureus isolates that are methicilin resistant (MRSA)

3Source: CDDEP 2015

Antibiotics use per capita by income

4Source: Van Boeckel et al. 2014, World Bank 2015

Antibiotic consumption in livestock

5Source: Van Boeckel et al. 2015

New molecular entity (NME) antibiotics still marketed in US by period of introduction

6Source: Outterson et al. 2013

Strategies to reduce antibiotics risk

7

Six strategies to mitigate risk of antibiotics becoming less effective:

1. Improve sanitation and immunization2. Improve hospital infection control and antibiotic stewardship3. Change incentive structure to favor effective antibiotic use4. Reduce and eventually eliminate sub-therapeutic antibiotic use in

agriculture5. Educate health professionals, policy makers, and the public on

sustainable antibiotic use6. Rally political commitments to meet rising risks of antibiotic

resistance

Percentage of MRSA Staphylococcus aureus isolates by country

8Source: CDDEP 2015, WHO 2014

Antibiotics use and sales

9Source: Van Boeckel et al. 2014

Percentage change in antibiotic consumption per capita 2000-2010 by country

10Source: Van Boeckel et al. 2015

Total antibiotic consumption in selected countries

11Source: Van Boeckel et al. 2014

Global antibiotic consumption in livestock (2010)

12Source: Van Boeckel et al. 2015

Antibiotic consumption in livestock in high-consuming countries

13Source: Van Boeckel et al. 2015

Population without access to improved sanitation

14Source: WHO/UNICEF 2014

History of consumption and price of antibiotics

15

Overview of FDA Drug Development Process

16Source: FDA

Conclusions

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• The greater the volume of antibiotics used, the greater the chances that antibiotic-resistant populations of bacteria will prevail in the contest for survival of the fittest at the bacterial level• The antibiotic pipeline is innovative; however, needs help from

public policy to readjust incentives• New antibiotics must be affordable in lower-income countries as

well in high-income countries• Other approaches to infection control and treatment will also help

maintain the effectiveness of current and emerging antibiotics• A balanced approach focusing on antibiotics development and

vaccines (for both humans and animals), diagnostic technologies, and complementary and alternative technologies, such as bacteriophages.