Antibiotics
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Antibiotics All antibiotics cross placenta. Adverse effects to fetus are rare except few. E.g – Aminoglycosides should be avoided in pregnancy ‘coz of their ototoxicity in fetus. Young children should not be treated with Tetracycline: effect bone growth Fluoroquinolones: interfere with cartilage growth Chloramphenicol & Sulfonamides : toxic effects ‘coz of poor developed renal & hepatic function β lactams & Aminoglycosides shows synergism. Gram +ve Pneumonia Diphtheria Tetanus Diarrhea (pseudo membranous colitis) Boils, septicemia, food poisoning, wound infections, tonsillitis, rheumatic fever, otitis media, meningitis, endocarditis, dental caries, instrument contaminations, catheter infections All staph & strep. , clostridium are gram +ve Gram -ve Gonorrhea Meningococcal Meningitis E.coli infections Typhoid (enteric fever), Malaria Peptic ulcers (H.pylori) Cholera, T.B, Leprosy, syphilis Oral thrush (oral candidiasis), Athlete’s foot (Tinea pedis) Abscesses (puss), ring worm) Traveler’s diarrhea (shigella, salmonella) UTI (90%), diarrhea, food poisoning, dysentery (bloody diarrhea) Nosocomial infections (Pseudomonas aeruginosa) All Nisseria, Pseudomonas, Hemophilus, are Gram -ve
description
ANTIBOITICS
Transcript of Antibiotics
Antibiotics
AntibioticsAll antibiotics cross placenta.
Adverse effects to fetus are rare except few. E.g Aminoglycosides should be avoided in pregnancy coz of their ototoxicity in fetus.
Young children should not be treated with
Tetracycline: effect bone growth
Fluoroquinolones: interfere with cartilage growth
Chloramphenicol & Sulfonamides : toxic effects coz of poor developed renal & hepatic function
lactams & Aminoglycosides shows synergism.
Gram +vePneumonia
Diphtheria
Tetanus
Diarrhea (pseudo membranous colitis)
Boils, septicemia, food poisoning, wound infections, tonsillitis, rheumatic fever, otitis media, meningitis, endocarditis, dental caries, instrument contaminations, catheter infections All staph & strep. , clostridium are gram +ve
Gram -ve
Gonorrhea
Meningococcal Meningitis
E.coli infections
Typhoid (enteric fever), MalariaPeptic ulcers (H.pylori)
Cholera, T.B, Leprosy, syphilisOral thrush (oral candidiasis), Athletes foot (Tinea pedis)
Abscesses (puss), ring worm)
Travelers diarrhea (shigella, salmonella)
UTI (90%), diarrhea, food poisoning, dysentery (bloody diarrhea)
Nosocomial infections (Pseudomonas aeruginosa)
All Nisseria, Pseudomonas, Hemophilus, are Gram -ve
Amoxicillin & Ampicillin interact with
Allopurinol (rashes) Oral Contraceptives (contraceptive effect)
They also causes anaphylaxis, GI side effects (N.,V.,diarrhea), thrombocytopenia, agranulocytosis, leucopenia.
