Anti Pyre Tics
-
Upload
disha-dhairyawan -
Category
Documents
-
view
219 -
download
0
Transcript of Anti Pyre Tics
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 1/17
ANTIPYRETICSPRESENTED BY-
BRUCHELLE PEREIRA.
DISHA DHAIRYAWAN.
DR KAVITA BADGUJAR.
DR PARAG SARVE.
MSC CR (2010-12), ICRI MUMBAI.
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 2/17
CONTENTS
INTRODUCTION
DRUG INFORMATION
DOSAGE FORMS RECENT DEVELOPMENTS
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 3/17
INTRODUCTION
Antipyretic drugs are class of drugs that are
used to prevent or reduce fever.
Do not affect normal body temperature.
Reduce body temperature from raised state
in case of bacterial or viral triggered defense
mechanism.
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 4/17
DRUG INFORMATION
PARACETAMOL
It is a type of NSAIDS(non steroidal anti-
inflammatory drugs). Deacetylated active metabolite of phenacetin
Chemical name - Para-aminosalicyclic acid.
Non-proprietary name Acetaminophen.
Proprietary name (Brand name) Crocin,Calpol, Panadol etc.
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 5/17
DRUG INFORMATION CONTD.
Mechanism of action-
Inhibits synthesis of prostaglandins in the
CNS and peripherially blocks pain impulse.Hence also used as analgesic widely.
Decreased levels of prostaglandins leads to
decreased effect of microbial pyrogens onheat regulating centers in brain & produces
antipyresis.
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 6/17
DRUG INFORMATION
PARACETAMOL
Dosage according to age -
Infants :50mg.
Children (1-3yrs ): 80-160 mg.(4-8yrs): 240-320mg.
(9-12yrs): 300-600 mg.
Adults: 0.5 -1g TDS (total daily dose ) not toexceed 2.5g .
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 7/17
DRUG INFORMATION CONTD
Advantages of Paracetamol-
Well tolerated & Safe.
Does not lead to gastric irritation, ulceration or
bleeding as in case of aspirin.No significant drug interactions.
Hypersensitivity is rare.
No acid-base disturbances.
Safely used in infants, pregnant, lactatingwomen & in patients where NSAIDScontraindicated .
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 8/17
DRUG INFORMATION CONTD
PARACETAMOL is available in various oral &parenteral dosage forms.
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 9/17
PARACETAMOL TABLETS.
Dose 500 mg, 1.0g .
Brand name Crocin , Calpol, Panadol.
Manufacturers Glaxosmithklinepharmaceuticals (crocin), Aurobindo pharma,
Cipla limited etc.
Glaxosmithkline in 2003 has launched Crocinpain relief containing paracetamol&caffeine
as actives.
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 10/17
PARACETAMOL CAPSULES
DOSE- 500 mg -1g.
Can be used in children over 12yrs.
Brand name -Boots Paracetamol capsulesMfg by Boots pharmaceuticals .
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 11/17
PARACETAMOL SYRUP
DOSE 125mg/5 ml , 150mg / ml syrup.
Brand name- Aeknil syrup drops, Metacin,
Paracin ,Apecin paracetamol syrup etc Manufacturers Arihant pharmaceutical
works (Apecin), Therapeutic pharmaceuticals
(Aeknil syrup ).
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 12/17
PARACETAMOL ELIXIR
Paracetamol dissolved in defined quantities of
alcohol.
Dose 120mg/5ml. Dose repeated every 4hrsupto 4 times a day.
Brand name - Panadol Paracetamol elixir.
Manufactured by- Cynosure pharma UK
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 13/17
PARACETAMOL SUSPENSION
Dose -150mg/5ml
Brand name Crocin suspension in strawberry
flavour (1-5 yrs of children) Crocin suspension double strength in mixed
fruit flavour (5-12yrs) .
Manufactured by Glaxosmithkline .
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 14/17
PARACETAMOL I.M INJECTION
Dose 150mg/ml.
Brand name- Aeknil Paracetamol I.M injection.
Manufactured by Aeknil Pharmaceuticals
Uses febrile convulsion , post operative
trauma , when oral medication is not possible.
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 15/17
PARACETAMOL SUPPOSITORIES
Dose 300mg per suppository
Used in paedriatic patients for mild to
moderate pain & fever. Brand name Doliprane
Manufactured by Aventis pharma.
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 16/17
RECENT DEVELOPMENTS
FDA approval for Acetavance Paracetamol I.Vinjection by Cadence pharmaceuticals on2ndNov 2010.
Antipyretics like paracetamol , aspirin,dipyrine are used for modifying the labellingblood elements with tectnetium(nuclearmedicine).
Crocin quick works twice times as regularparacetamol tablet launched by GSK .
8/3/2019 Anti Pyre Tics
http://slidepdf.com/reader/full/anti-pyre-tics 17/17
THANK YOU !!!