Anthropometry and Breast Cancer Publication
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Transcript of Anthropometry and Breast Cancer Publication
Anthropometry and Breast Cancer Publication
van den Brandt, P.A., et al. Pooled analysis of prospective cohort studies on height, weight and breast cancer risk. American Journal of Epidemiology. 2000; 152: 514-527.
Sweden Mammography
CohortNurses’ Health Study
Netherlands Cohort Study
New York State Cohort
Iowa Women’s Health Study
Canadian National Breast Screening Study
Cohort Studies in the Pooled Analysis of Anthropometry and Breast Cancer
Total = 337,819 # cases = 4,385 Premeno. = 723 Postmeno. = 3,208
Adventist Health Study
Number of Cases in the Pooled Analysis of Anthropometry and Breast Cancer
Study No. of cases Premeno. Postmeno.
Adventist Health 20 87
Canadian National
122 242 Iowa Women’s
0 643 Netherlands Cohort 0
420 New York State 0
358 Nurses’ Health (a) 383
571 Nurses’ Health
(b) 130 613
Sweden Mammography 68 274 van den Brandt et al, 2000
Pooled Multivariate Relative Risks for Breast Cancer and Body Mass Index
BMI (kg/m2) RR (95% CI) Premenopausal Postmenopausal
<21 1.00 (ref) 1.00 (ref)
21-<23 1.24 (0.97-1.57) 1.14 (0.99-1.33)
23-<25 1.03 (0.78-1.35) 1.15 (1.00-1.34)
25-<27 1.08 (0.79-1.48) 1.26 (1.09-1.47)
27-<29 0.97 (0.66-1.44) 1.43 (1.21-1.67)
29-<31 0.96 (0.60-1.52) 1.21 (1.01-1.46)
31-<33 0.55 (0.26-1.15) 1.29 (1.03-1.60)
>33 0.58 (0.34-1.00) 1.27 (1.03-1.55)
p for trend 0.007 0.001 p-for-interaction = 0.004
van den Brandt et al, 2000
Study-Specific Relative Risks for Premenopausal Breast Cancer and BMI
van den Brandt, et al. 2000Relative Risk.51 5
Combined
Sweden
Nurses' (b)
Nurses' (a)
Canada
Study-Specific Relative Risks for Postmenopausal Breast Cancer and BMI
Relative Risk.8 1 2
Combined
Sweden
Nurses' (b)
Nurses' (a)
NY State
Netherlands
Iowa
Canada
Adventist
van den Brandt, et al. 2000
Body Mass Index and Breast Cancer: Pooled Analysis
van den Brandt et al, 2000
Pooled Multivariate Relative Risks for Breast Cancer and Height by Menopausal Status
Height (m) Premenopausal Postmenopausal
<1.60 1.00 (ref) 1.00 (ref)
1.60-<1.65 1.21 (0.94-1.55) 1.09 (0.98-1.21)
1.65-<1.70 1.06 (0.82-1.36) 1.23 (1.11-1.37)
1.70-<1.75 1.14 (0.86-1.52) 1.24 (1.09-1.41)
>1.75 1.42 (0.95-2.12) 1.28 (0.94-1.76)
p for trend 0.41 <0.001
p-for-interaction = 0.13 van den Brandt et al, 2000
Study-Specific Relative Risks for Premenopausal Breast Cancer and Height
Relative Risk.6 1 2
Combined
Sweden
Nurses' (b)
Nurses' (a)
Canada
van den Brandt et al, 2000
Study-Specific Relative Risks for Postmenopausal Breast Cancer and Height
Relative Risk.8 1 2
Combined
Sweden
Nurses’ (b)
Nurses’ (a)
NY State
Netherlands
Iowa
Canada
Adventist
van den Brandt, et al. 2000
Pooled Multivariate Relative Risks for Breast Cancer and Height
van den Brandt et al, 2000
0.8
1.0
1.2
1.4
1.6
1.8
<1.60
1.60
-<1.
65
1.65
-<1.
70
1.70
-<1.
75
>1.75
Rel
ativ
e R
isk
Height (m)
Van den Brandt et al, 2000
van den Brandt et al, 2000
Height and Breast Cancer: Pooled Analysis