ANNUAL REPORT - UW Health

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2010ANNUALREPORT

TABLE OF CONTENTS

Year in Review

Researcher Expands Retina Program

Strong Connections Between Doctors & Patients

Donation Supports Care for Patients with AMD

A Day in the Life:Residency Prepares Doctors

Grants 21

Clinical & Research Faculty & Staff 22

Clinical Trials 24

Publications 26

Donor Honor Roll 30

Volunteer & Affiliate Faculty Members 31

Financial Highlights 31

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FROM THE CHAIR

2010 ANNUAL REPORT

Each year in our annual report we share a few of the many wonderful

stories from the University of Wisconsin Department of Ophthalmology and Visual Sciences. This year we illustrate examples of the interrelationship among the three facets of our mission: research, clinical care and education.

Basic science researcher Aparna Lakkaraju, PhD, is making great strides as she seeks to understand macular degeneration at the cellular level. She has brought great enthusiasm and new ideas after having completed her doctorate at the University of Minnesota and a post-doctoral fellowship at Cornell University. Dr. Lakkaraju is drawn to academic research because she enjoys working with collaborators who care for human patients. It is her goal to translate the research taking place in her laboratory to breakthroughs that improve patient care.

Barbara Blodi, MD, is a clinical researcher who also sees patients with retina problems. Work like hers will one day translate the discoveries made in our laboratories directly to the patients in our clinics. Like many other physicians, Dr. Blodi is proud to work with the basic scientists and to teach residents and fellows who train at the UW.

One of those residents is senior Timothy Daley, MD, who will continue in the Department as a fellow in pediatric ophthalmology and adult strabismus. Our most direct link to the future of ophthalmology is educating the residents, fellows and medical students who pass through our doors. We are proud of their work.

Equally important to us is the education of our patients, explaining the basics of disease or the translational research breakthroughs we are making.

An example of this patient education is the biennial Age-related Macular Degeneration symposium, where more than 500 people come to learn about the disease. In addition to people with macular degeneration and their caregivers, we have connected with public officials who deepen their understanding of this disease. This helps them make and implement health policy more effectively.

We are grateful, as always, to the donors who help further the work we do here. The new horizons and opportunities presented by the explosion of scientific knowledge stand in stark contrast to the difficulty of obtaining the decreasing federal funding to pursue them. We are fortunate to play a part in advancing vision science, and our basic science and clinical researchers continue to compete effectively for these grants. However, the generosity of our donors has made the crucial difference in our department staying strong as we move to the future.

Research, clinical care, and education all overlap to form a continuum of excellence. We are pleased to share this journey, and these stories, with you.

Paul L. Kaufman, MD

Peter A. Duehr Professor and Department Chair

UW Department of Ophthalmology and Visual Sciences

University of Wisconsin School of Medicine and Public Health

UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES2

YEAR IN REVIEWNEW FACULTY/STAFF jOIN DEPARTMENTCameron Parsa, MD, an ophthalmologist who specializes in pediatric ophthalmology and adult strabismus as well as in neuro-ophthalmology, joined the Department of Ophthalmology and Visual Sciences as associate professor in September 2010.

“Neuro-ophthalmology is a very broad subspecialty,” he said. “While the advent of neuro-imaging reduced the scope of the field from one previously essential in accurately localizing many brain tumors, it is more focused today on observational studies of the optic disc and nerve fiber layer, visible structures beyond the resolution of the MRI. It requires not only understanding the ocular manifestations of systemic and various neurological conditions, as is commonly perceived, but also quite frequently, how to detect the more subtle variants of common ocular conditions such as oil-droplet cataracts or even dry eye syndrome, which can masquerade as more ominous entities.”

Often problems manifest as misalignment of the eyes, which ties in with Dr. Parsa’s other subspecialty, pediatric ophthalmology and adult strabismus.

Dr. Parsa joined the Department after spending six years at The Krieger Children’s Eye Center of the Wilmer Ophthalmological Institute at The Johns Hopkins Hospital in Baltimore, Maryland, where he previously also worked in The Johns Hopkins Center for Hereditary Eye Diseases.

Cameron Parsa, MD

Cameron Parsa, MD, examines eye movements that would specifically pinpoint a brain anomaly in Ariana Cabrera, who traveled from Beloit, Wisconsin, to see a specialist at UW Health Eye Clinic. Dr. Parsa is both a pediatric ophthalmologist and a neuro-ophthalmologist.

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In addition to his clinical practices, he conducts clinical and theoretic research designed to immediately impact the clinical practice of ophthalmology. His recent publications describe the demonstration of an individual’s systemic inherited potential for angiogenesis via the analysis of optic nerve findings in various syndromes, the origin of port-wine stains, glaucoma and seizures in the Sturge-Weber syndrome and related diseases as simply due to venous dysplasia, and the nature of optic gliomas. His research has recently determined that this juvenile brain tumor represents a hamartoma rather than a neoplasm and that treatments now given for this tumor are actually ineffective and increase the risk of malignant transformation later in life.

Dr. Parsa sees patients at UW Health University Station Eye Clinic in Madison and Affinity Ophthalmology Offices in Menasha.

Richard Patterson, OD, joined the Department in March 2010. He had previously worked in private optometry practice.

Dr. Patterson brings experience with optics to the practice of optometry. “The science of optics is complex,” Dr. Patterson said, “and our patients consistently wanted to know more about their lens correction in a way they could understand. I discovered that I could relate their changes in eyesight in a non-technical way that helped them get a better handle on it. To me, that was the spark that led to my wanting to pursue my doctor of optometry training.

“It was all about developing the relationship with a patient.”

Dr. Patterson attended Indiana University – Bloomington to earn his doctor of optometry degree. He and his family moved to Madison in 2001 where he began to serve several Southern Wisconsin communities with his optical and optometric skills. In addition to providing clinical care to keep patients’ eyes healthy, Dr. Patterson maintains his strong interest in optics, and enjoys being part of a full-service medical clinic delivering comprehensive eye care to the community and partnering with UW Health ophthalmologists and opticians.

SELECTED FACULTY AWARDS 2010

Best Doctors in America

Gregg A. Heatley, MD Paul L. Kaufman, MDBurton J.Kushner, MD Leonard A. Levin, MD

Castle Connolly Top Doctors

Daniel M. Albert, MD, MS Paul L . Kaufman, MD Burton J. Kushner, MD Todd W. Perkins, MD

Consumer’s Research Council of America’s Top Ophthalmologists

Mark J. Lucarelli, MD

Fellow of the Association for Research in Vision and Ophthalmology

Leonard A. Levin, MD (Gold) Robert W. Nickells, PhD (Silver) T. Michael Nork, MD, MS (Silver)

Cameron Parsa, MD, looks over images for a patient with Darla Coullard, an ophthalmologic technician at UW Health University Station Eye Clinic. Having and keeping old images on file allows for helpful comparisons during the examination and to assess for any disease or progression.

Richard Patterson, OD


YEAR IN REVIEW continued

LABS MOVED FOR MENTORINGWhen a new researcher, such as Aparna Lakkaraju, PhD, joins the Department of Ophthalmology and Visual Sciences, a formal mentoring committee is set up to provide support and advice.

In Dr. Lakkaraju’s case, one of the researchers on her mentoring committee, Curtis Brandt, PhD, moved his laboratory space next to Dr. Lakkaraju’s laboratory in the Medical Sciences Center (the old University Hospital)

to facilitate collaboration and a supportive relationship. It also allows Dr. Brandt and his staff to have access to state-of-the art technology of new laboratory space.

In the past, many new faculty created their own informal mentoring relationships. The mentoring committee is established to provide formal support to new faculty members. A formal system ensures that new faculty have a team dedicated to helping grow research opportunities.

Curtis Brandt, PhD, and Aparna Lakkaraju, PhD, often discuss research projects during the course of their work days. Collaboration is facilitated by Dr. Brandt moving his labratory into space next to Dr. Lakkaraju’s new laboratory.

Aparna Lakkaraju, PhD

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NEW DIRECTOR LEADS RESIDENCY PROGRAMStephen Sauer, MD, took over leadership of the Department’s Residency Program in July 2010, when Yasmin Bradfield, MD, stepped down after leading us to successful reaccreditation in 2009. Dr. Sauer served as director of Core Competencies, a key aspect of the residency program, and brings a wealth of education experience to the role. He will build on a program that is stronger than ever, expanding and adding rotations and preparing for international service for our residents.

Dr. Sauer was awarded the University of Wisconsin Hospitals and Clinics Program Director Administrative Fellowship in 2010.

ELECTRONIC MEDICAL RECORD IMPLEMENTEDThe Department took its first steps toward implementing an electronic medical record (EMR) system in 2010. Although groundwork began several years earlier, in 2010 the first clinicians began using the Epic-designed system. UW Health has rolled out this EMR to all departments, allowing physicians and patients to have access to medical records throughout the organization.

Optometrists and comprehensive ophthalmologists use the medical record system for documenting patient exams. The system will be rolled out to subspecialists in 2012.

SELECTED FACULTY AWARDS 2010

Madison Magazine Top Doctors

Gregg A. Heatley, MD

American Academy of Ophthalmology Life Achievement Honor Award

Daniel M. Albert, MD, MS

UW School of Medicine and Public Health Dean’s Award for Association of American Medical Colleges Early Career Women Faculty Seminar in Washington, D.C.

Heather A.D. Potter, MD Yasmin S. Bradfield, MD

Retina Research Foundation/Kathryn and Latimer Murfee Chair

David M. Gamm, MD, PhD

Foundation Fighting Blindness Board of Directors Award for Retinal Degenerative Disease Research

David M. Gamm, MD, PhD

Stephen Sauer, MD

An ophthalmology technician enters patient information into UW Health’s electronic medical record system. This kind of system facilitates improved patient care and sharing information among all health care providers.


RESEARCHER EXPANDS RETINA PROGRAM

RESEARCHCollaboration is keyCollaboration is key

Shelves are slowly filling in Aparna Lakkaraju’s laboratory in the Medical

Sciences Building on the University of Wisconsin campus. As the newest researcher in the Department of Ophthalmology and Visual Sciences, Dr. Lakkaraju is just settling into her space, and work is already progressing.

Dr. Lakkaraju joined the Department in June 2010 from Cornell University where she was a post-doctoral researcher. She earned her doctorate at the University of Minnesota.

The Department at the University of Wisconsin offers the opportunity to build a lab, but more important to Dr. Lakkaraju, it offers colleagues with whom to collaborate on research to understand and eliminate blinding diseases.

“This is a top-ranked department,” she said. “There are a lot of people to collaborate with in the Department and across campus.” This includes researchers within the Department of Ophthalmology and Visual Sciences, such as Nader Sheibani, PhD, who studies some of the same cells as Dr. Lakkaraju in the context

of diseases such as diabetic retinopathy. She also collaborates with Robert Nickells, PhD, vice chair for Research in the Department, Curtis Brandt, PhD, a virologist who moved part of his laboratory to be next to her laboratory space, and David Gamm, MD, PhD, a researcher who studies stem cells in retinal diseases.

She received a career development award from Research to Prevent Blindness, which provides her with four years of funding as she builds her research program here. The Department, which has an unrestricted grant from RPB, nominated her for the award. Dr. Lakkaraju credits the reputation of the department and the strong support of the Chair, Paul Kaufman, MD, for her success in getting the award. Dr. Lakkaraju also received a vision research grant from the Karl Kirchgessner Foundation shortly after arriving at the University of Wisconsin.

Aparna Lakkaraju, PhD, and her Assistant Scientist, Jin Xu, MD, MS, view images of a cell using the spinning disk confocal microscope Dr. Lakkaraju is testing for her lab.

Collaboration is key

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Collaboration is keyRetina diseases focus of research

Age-related macular degeneration (AMD) is the most common cause of vision loss in the elderly in developed countries. Because retinal degenerative disease, such as macular degeneration, is a growing area of research nationally, the Department of Ophthalmology and Visual Sciences recently remodeled the space Dr. Lakkaraju now occupies to attract such a researcher.

“It has been part of our strategic plan to expand our basic science studies in retinal diseases,” said Dr. Nickells. “We are very excited to have Dr. Lakkaraju join us as part of our mission to expand in this area.”

As a cell biologist, Dr. Lakkaraju seeks to understand what happens in AMD at the cellular level. She is particularly interested in the retinal pigment epithelium (RPE), a thin layer of cells making up the outermost layer of the retina. “These cells perform many functions that are necessary for vision,” she explained. “They are also the site of the initial insult in AMD and other inherited and acquired retinal degenerations. Each RPE cell is responsible for 30 to 40 photoreceptors, so when the RPE dies off, it takes with it photoreceptors needed for vision. The RPE is truly indispensable for vision.“

Understanding disease processes at the level of the cell is important to developing prevention strategies and cures for blinding disease, she continued. A major hurdle to developing effective therapies for AMD is that it is not a simple disease, but one that has many genetic and environmental causes. So teasing out exactly what happens in the disease has been an enormous challenge. Aparna Lakkaraju , PhD, prepares cells for imaging in her laboratory. Dr. Lakkaraju’s lab studies retinal pigment epithelial cells

which they isolate from human and animal eyes.


RESEARCH continued

“People typically look at the whole organism,” she said. “But mice, for example, are nocturnal animals that do not have a macula, the part of the retina that is responsible for fine, high-resolution vision found in humans. In AMD, damage to the macula makes people lose central vision. Studying this disease solely in mice will only provide limited insight into what leads to blindness in humans.”

Dr. Lakkaraju is able to study this disease because she can use RPE cells from humans, both those with and without macular degeneration. “She can look at them and see how they are different in a person with the disease,” Dr. Nickells said.

So far, her research has demonstrated that A2E, a by-product of the visual cycle that accumulates with age in the RPE, traps cholesterol within these cells. Because cholesterol is an important risk factor in other age-related diseases like Alzheimer’s disease, Parkinson’s disease and heart disease, she is seeking to understand how cholesterol is handled in the RPE and retina.

Dr. Lakkaraju also is studying apolipoprotein E, a protein that transports cholesterol within cells and between different tissues. It occurs in three forms. One variation is thought to be a predictor for Alzheimer’s disease, but may offer protection for AMD. Dr. Lakkaraju hopes that her work in RPE cells will help us understand how this protein can be a risk factor for one age-related disease, but protect from another. Apolipoprotein E also dictates how cells respond to statins, one of the most commonly used medicines in the world to treat atherosclerosis (hardening of the arteries). Statins may be beneficial in AMD, but studies on the link between statin use and AMD in humans have been inconclusive. Understanding how RPE cells respond to statins will go a long way toward resolving this.

A second area of her research is aimed at understanding how lysosomes, which function as the cell’s garbage disposal system, are altered with age and cellular stress. This is especially important for the RPE because every morning, these cells are fed a huge breakfast of “used up” parts of photoreceptors. This is like eating 100 bagels for breakfast every day. Because RPE cells do not regenerate like cells on

our skin or cells that line the gut, the RPE garbage disposal system becomes less efficient as we grow older. One hallmark of AMD is the accumulation of undigested fats and proteins within these cells over time, leading to a virtual “garbage catastrophe.” Dr. Lakkaraju uses high-speed microscopy to see how the cell’s garbage disposal system works in health and disease.

“We are passionate about conducting translational research, and we look forward to the day when breakthrough discoveries made in the lab can be taken to the clinic to benefit patients.”

Aparna Lakkaraju, PhD

Apart from high-speed, high-resolution microscopy, the Lakkaraju lab also uses standard biochemical and molecular biology techniques to analyze proteins and lipids from healthy and diseased RPE cells.

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Having the right tool

Dr. Lakkaraju’s exacting research often requires special tools. She has used spinning disk confocal microscopy to peer into living RPE cells as they go about their functions. Although her laboratory does not yet own this specialized instrument, she has been able to test one while she decides among the appropriate machines and secures funding for it. Conventional confocal microscopes use high levels of light to illuminate the entire sample from a single pinhole, causing phototoxicity during live imaging. A spinning disk microscope has a disk with an array of pinholes that spins very fast and illuminates the sample at very low levels of light. The multiple pinholes are critical for high-speed imaging, allowing Dr. Lakkaraju to visualize changes in living cells that occur on timescales of milliseconds.

Seeing what is happening to a cell under stress and under normal conditions will help Dr. Lakkaraju understand what effect stress and inflammation have on cell health. This is a first step to translating her research to patient care.

“We are passionate about conducting translational research,” she said. “And we look forward to the day when breakthrough discoveries made in the lab can be taken to the clinic to benefit patients.”

Aparna Lakkaraju plans experiments with Jin Xu.


STRONG CONNECTIONS BETWEEN DOCTORS AND PATIENTS TIES IN WITH OUTSTANDING CARE

PATIENT CARE

One reason many ophthalmologists are drawn to their specialty

is the opportunity to form long-lasting relationships with their patients while also having a hands-on surgical practice. Many physicians like performing procedures, and ophthalmologists are no different.

But it is seeing their patients come back, year after year, that keeps many doctors engaged in their practices. University of Wisconsin Department of Ophthalmology and Visual Sciences ophthalmologist Barbara Blodi, MD, is no exception.

Like other retina specialists, Dr. Blodi often needs to follow up with her patients frequently. Those who receive injections of Avastin or Lucentis for wet age-related macular degeneration (AMD) are in her office once a month or so. “I really get to know these people,” she said. “It’s almost like internal medicine or family medicine, where I learn so much about my patients and their families,

and they know about mine.” There are seven retina specialists in the department who perform these injections and all have the same experience of forming close ties to their patients.

Georgette Bathum, of Madison, has been seeing Dr. Blodi since 2007. “I was referred to her by an ophthalmologist in Dubuque, Iowa, Gretchen Fuerste, MD, because I had macular degeneration,” Bathum said. “From the beginning, I felt Dr. Blodi had the expertise to take care of my eyes.”

“It’s almost like internal medicine or family medicine, where I learn so much about my patients and their families, and they know about mine.”

Barbara Blodi, MD

Georgette Bathum and her daughter, Mary Elizabeth Bathum, enter the UW Health University Station Eye Clinic for an appointment.

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Bathum is a retired nurse and knows medical expertise. In addition to competence, Bathum likes Dr. Blodi’s caring. “She is kind,” Bathum said. “She’s gentle, but you know what’s happening. She’s direct. I feel very comfortable in her hands and I have from the beginning. What she recommends, I do.”

It’s that trust in Dr. Blodi’s capabilities as well as her personality that led Bathum to agree to participate in a clinical trial, the Age-Related Eye Disease Study 2 (AREDS2) for macular degeneration. AREDS2 is comparing the progression of macular degeneration in patients who receive supplements of lutein or fish oil (or both) with patients who do not receive any supplements, Dr. Blodi explained. All patients in the AREDS2 study are receiving the standard formula of eye vitamins developed as a result of the original AREDS trial. Although she has convinced herself that she was randomly assigned to the group that is receiving placebo and not receiving a supplement, Bathum still believes in clinical trials. “It is helping learn what care is best,” she said.

Georgette Bathum checks in for her eye clinic appointment with medical receptionist Julie Grim.


PATIENT CARE continued

Dr. Blodi notes that a clinical trial comparing one treatment with another under careful monitoring is the best way to demonstrate which of the treatments is best. This careful monitoring includes photographs or optical coherence tomography of the affected eyes at each visit. This allows researchers to understand how the medications being studied are working at every point in time, not just at the beginning and end of the study. The technician prepares the patient for an injection, if one is needed. This includes numbing the eye, using a sterile prep and getting the medication. Medications are prepared by the UW Health pharmacist in the building. “This is a real team effort,” Dr. Blodi said.

Bathum had been losing her vision rapidly soon after she began seeing Dr. Blodi. She developed the wet form of macular degeneration and began receiving injections of Lucentis into her eye. The injections were proven in earlier studies to improve vision and delay blindness in people with the onset of wet AMD.

As a result of the injections, Georgette has been able to keep up with her active lifestyle. She and her daughter, Mary Elizabeth Bathum, own a condominium in a co-housing complex in Madison. Georgette is able to go to exercise class, take classes at the University of Wisconsin and attend courses in the UW Arboretum, as well as volunteer at a local nursing home.

Barbara Blodi, MD, chats with her patient, Georgette Bathum, and Georgette’s daughter Mary Elizabeth Bathum. Mary Elizabeth accompanies her mother to most eye clinic appointments.


“This treatment has allowed me to continue doing the things I enjoy,” Georgette said.

Mary Elizabeth, who is able to drive her mom to most appointments – driving immediately after an injection is not recommended – said that having the injections as an option for her mother was a great relief. “It felt good to have some hope,” she said.

Georgette agreed. “Any hope was wonderful,” she said. “I still feel that way.”

Although the AREDS2 study will be completed in about a year, Georgette will request to remain Dr. Blodi’s patient from now on. And Dr. Blodi is looking forward to knowing Georgette and Mary Elizabeth even better.

“This treatment has allowed me to continue doing the things I enjoy.”

Georgette Bathum

Barbara Blodi, MD, examines Georgette Bathum’s eyes during a check-up visit. Georgette’s daughter, Mary Elizabeth Bathum, looks on.


EDUCATIONA Day in the Life

RESIDENCY PREPARES DOCTORS FOR FUTURE PRACTICEA Day in the Life

When Timothy Daley, MD, stepped off the elevator to greet his first patient

of the day, he had already been working for more than two hours. As chief resident in the Department of Ophthalmology and Visual Sciences, Dr. Daley not only attends the same lectures and education programs as his colleagues, he often is involved in planning and organizing them as well.

On Fridays, the nine residents in the University of Wisconsin School of Medicine and Public Health ophthalmology residency start their day at 7 a.m. with Retina Workout. Each week a UW Department of Ophthalmology and Visual Sciences retina specialist goes over cases of interest and the group discusses the issues and treatment options.

Following Retina Workout, the entire group of residents moves across the hall to Grand Rounds. Organized by each year’s chief resident, Grand Rounds is a Continuing Medical Education-approved lecture series that features physicians and researchers from within the Department, others within the UW System and outside visiting professors. The topics

range from basic science talks, to interesting patient cases, to issues that affect the practice of medicine in general (such as patient safety), and to new practices and procedures in ophthalmology.

When Grand Rounds ended at 8:30 a.m. on a recent Friday, Dr. Daley hurried to the William S. Middleton Memorial Veterans Affairs Hospital, connected to the UW Hospital and Clinics, to see his first patients of the day. Dr. Daley spotted Claire Clark immediately, and led him down the hall to an exam room.

“Should we take this eye patch off?” Dr. Daley asked, as he gently removed the patch that had protected Clark’s eye since the prior day’s cataract surgery.

Clark answered yes, and was thrilled with his improved vision after the procedure. “This is heaven,” Clark said. “I was walking like I was drunk before.”

Dr. Daley checked Clark’s eye and explained the eye drops he would need to use for the next several weeks.

Timothy Daley, MD, listens during a Grand Rounds lecture. The talks are held weekly and help keep residents, faculty and others abreast of the latest news in ophthalmology.

A Day in the Life


A Day in the Life“If you have any questions, call right away,” Dr. Daley reminded his patient. “In fact, I’m on call this weekend, so if you call, I’ll be the person you talk to.”

As the senior resident at the Veterans Affairs Hospital, Dr. Daley examines patients on his own. His work includes regular eye clinic exams, pre-surgery check-ups, surgery and post-surgery check-ups as well. An attending physician on staff at the UW Department of Ophthalmology and Visual Sciences reviews every chart and sees patients if Dr. Daley requests. In addition, the attending physician sees every patient who is scheduled for a procedure such as laser or surgery.

On this day the attending physician was Andrew Thliveris, MD, PhD, chief of the Ophthalmology Service at the Veterans Affairs Hospital. First and second year residents have their cases followed more closely. And because an attending physician looks over every chart, the department can be sure residents are asking for help when it is needed.

“We really take pride in the fact that our patient outcomes for cataract surgery are better than the national standard whether residents are involved or not.”

Andrew Thliveris, MD, PhD

Timothy Daley, MD, walks with his first patient of the day, Claire Clark, of Lyndon Station. Clark had surgery the day before to remove a cataract and replace it with an intraocular lens.


EDUCATION continued

For Dr. Thliveris and other faculty at the UW, teaching residents is only possible if high quality patient care is maintained. “We really take pride in the fact that our patient outcomes for cataract surgery are better than the national standard whether residents are involved or not,” Dr. Thliveris said. “A high standard of care is the expectation here.”

Dr. Daley’s next patient is scheduled for surgery in the next few weeks. Dr. Daley explained all the risks and the benefits of a complicated operation, combining cataract and retinal surgery. Dr. Daley will perform cataract removal with implantation of a new lens and a faculty retina specialist will then do the retinal surgery. Making sure his patient understands exactly what is involved is an important part of Dr. Daley’s job. He took time to answer every question and explain steps in detail.

After seeing several more patients, Dr. Daley prepared for that day’s surgery.

As residents gain more experience, they are allowed to operate more independently, but attending staff is always scrubbed in in case their skills are needed. As a senior resident on this VA rotation, Dr. Daley also performs surgery on Friday afternoons, under the watchful eyes of Assistant Professor Daniel Knoch, MD.

Surgical procedures are carefully orchestrated, with a nurse anesthetist, a nurse and an operating room technician, in addition to Dr. Daley, Dr. Knoch and the patient. The patient confessed on this Friday before the Green Bay Packers played their arch-rival Chicago Bears for the Division Championship that he was pulling for the Bears.

Timothy Daley, MD, examines the eyes of Clarence Dahmen, Waunakee, who is preparing for surgery in the next few weeks.


“That’s OK,” Dr. Daley quipped. “We’ll take good care of you anyway.”

Cataract surgery is very common and Dr. Daley is experienced. But even so, Dr. Knoch served as surgical assistant and continually offered suggestions and used every teachable moment to increase Dr. Daley’s knowledge of ophthalmology and ophthalmic surgery.

After the procedure, residents and attending physicians can review video from the operating room’s microscope. The video tracks everything from the view of the surgeon, so everyone can learn from the experience. “Even when things go well, you can learn something to refine your technique,” Dr. Daley said. “We want better outcomes and we want to be more efficient.”

Surgery on Friday means patient visits on Saturday, even if he weren’t on call. “Surgery is an honor,” Dr. Daley said. “I will happily come in and see my patients on Saturdays.”

Dr. Daley, who completed medical school, internship and now his residency at the UW, will also obtain his fellowship training at the UW Department of Ophthalmology and Visual Sciences. He is choosing to concentrate on pediatric ophthalmology and adult strabismus (eye muscle problems).

But he likes his rotations at the VA Hospital. “You see a lot of interesting patients. It’s very rewarding. My grandfather was a World War II veteran,” he said. “A lot of my patients here remind me of him.”

Dr. Daley made his choice for ophthalmology when he was covering the emergency room during medical school. “A young man came in with a stick in his eye and I asked if I could follow along.”

Dr. Knoch was the senior resident on that case and Gary Sterken, MD, a faculty member in the Department, was the attending physician. “Other medical staff members were turning away, but I was really interested in how they were going to help him,” Dr. Daley said. “Dr. Knoch performed a simple and elegant procedure, with just a couple of stitches. The patient ended up having a great outcome, and I was hooked from then on.”

As his years as a resident near their end, Dr. Daley feels confident in treating a large variety of eye diseases. “During the interview process (for residency programs) you have the chance to see what it’s like in other places. I’m really glad I am able to be here at the UW.” UW faculty and patients like Mr. Clark are really glad that Dr. Daley is here at the UW too.

Dr. Daley chats with Lyne Kuhn, an ophthalmology technician at the Veterans Affairs Hospital.


MOM’S MEMORY LIVES ON

DONORSDonation Supports Care for Patients with AMD

Donna Fair’s children gathered recently and

reminisced about their mom. Fair, who passed away in June 2010, was remembered for her battle with lung cancer and for her generous spirit. And they recalled her “Dr. Mom” treatment of her children and grandchildren, as well as her ability to be a sounding board who offered advice as needed.

But she was also remembered for advocating for herself. And it wasn’t just her children who remembered that part of Fair. Ronald Danis, MD, who was her ophthalmologist at UW Health Eye Clinic - Rockford, recalled that she wanted to try Avastin injections for her age-related macular degeneration (AMD).

“She had been a patient for a while,” Dr. Danis recalled. “Her vision was 20-400 for about a year.” Fair had given up driving, had given up reading and had new challenges when taking care of her home.

Her youngest daughter, Carol Larson, of Loves Park, Ill., used tape and a black marker to put arrows on Fair’s stove and other appliances so that Fair could continue the chores of daily life and continue to live at home. “It was really hard to watch her go through that,” Larson recalled.

So one day Fair showed up for her appointment with Dr. Danis with an article about Avastin, a then-new drug that was helping people with AMD improve their vision. News about clinical trials of Avastin had recently been presented to ophthalmologists, but Dr. Danis had limited personal experience with the drug.

“She gave me the newspaper article and told me she wanted me to try that,” Dr. Danis said. “I was hesitant. The drug works best when used early in this disease process and we had no indication that it would restore vision in someone who had been legally blind for more than a year. Without having clinical trial information,

Chloe Gomez (clockwise from bottom left) her mother, Melissa Gomez, Melissa’s mother, Barbara Hevrin and Barbara’s mother Donna Fair. Fair’s family made a donation to UW Health Rockford Eye Clinic in her memory after she passed away in 2010.

Ronald Danis, MD


I told her I was skeptical it would help her longstanding poor vision.”

Fair insisted. After all, she believed in advocating for herself. Following careful consideration, Dr. Danis started a series of monthly injections in one eye.

A month after the first injection, Fair returned to the clinic. “When we checked her vision, she could not see any better, but she felt like she was seeing more clearly,” Dr. Danis said. “Then she asked to have injections in both eyes.”

Miraculously, Fair’s vision improved. Within a few months, her vision improved to 20-40 and she was able to drive herself to her appointments. She was able to read again, something she had always loved and had missed. She took down the telephone with oversize numbers and replaced it with a normal phone. She was able to pull the taped-on labels off her appliances. She could see.

It was Fair herself who said her restored vision was a miracle. She was grateful to be able to enjoy her freedom. So when she was diagnosed with lung cancer, and her children and friends prayed for a miracle cure to the cancer, Fair didn’t push it.

“She said ‘God doesn’t give that many miracles, and I’ve had mine.’ I still prayed for a miracle,” Larson said.

“We all did,” added her sister, Barbara Hevrin, of Rockford, Ill.

Even when she was fighting the cancer, and sick from chemotherapy treatments, she saw Dr. Danis for her Avastin injections.

“She was such a neat lady,” Dr. Danis said. “She was one of the most perseverant folks I’ve met.

Four of Donna Fair’s children, (back row) Carol Larson, David Barrie, Barbara Hevrin and Duane Barrie, gathered recently to remember their mom.


DONORS continued

Even when she was ill, she always came in for her eye visits. She was positive and always seemed grateful for her vision.”

Indeed, she was grateful. Whether cooking her famous potato salad and pies or spending time with her family at the lake, Donna Fair loved being able to see. With grandchildren and great grandchildren to love, it was a pleasure to her to watch them grow up.

When their father died, the family didn’t have the opportunity to use memorial donations for charity. But when their stepfather, George Fair, died, Donna decided to use the money to support community areas George believed in. She was an example to her children, yet again.

Being grateful for her support, it seemed natural that when Fair passed away, her family would use the memorial gifts to help other people. They selected three charities to share in the gifts given in their mother’s memory. In addition to her church and hospice, both of which provided comfort and support, the family chose the UW Health Eye Clinic-Rockford, which gave her a miracle.

When the family made the donation to the Eye Clinic, they asked that it be used to improve care for other patients with macular degeneration. It will go to help fund advanced imaging machines that continue to help improve treatment of people with AMD.

The family thinks Fair would like the choices they made. “She would like knowing this was going to help other people,” said her son, David Barrie of Winnebago, Ill.

When patients or families make donations, physicians are not always aware of why the gift was given. Dr. Danis said he was flattered and honored that Donna thought so highly of her care. “I can’t disagree with her that this was a miracle. But I was just the conduit,” he said. “We were using technology and treatment that has been developed through the collaborative efforts of thousands of people.”

Beyond regaining her sight, Donna liked going to the Eye Clinic, and staff there liked her, too. “They would come around the counter and hug her,” Hevrin said. “They were so friendly. We wanted to make this gift as a thank you for being so nice to her. Look at what this meant to her.”

Donna will be remembered for touching the hearts of all who knew her, and by way of her gift, she will be helping improve vision in people who have never had the enjoyment of getting to meet her.

“We were using technology and treatment that has been developed through the collaborative efforts of thousands of people.”

Ronald Danis, MD David Barrie listens as his sister, Carol Larson, recalls her mother’s wish to instill self-reliance in her children, while helping others as well.


Albert, DanielAMA Archives of Ophthalmology Journal EditorshipNATIONAL CHILDHOOD CANCER FOUNDATION Children’s Oncology Group

Brandt, CurtisRRH Gene Therapy for Retinal Degenerative DiseasesDHHS, PHS, NIH Virion Sialic Acid and HSV Ocular Infection

Colley, NansiDHHS, PHS, NIH Molecular Studies of Retinal Degeneration in Drosophila

Cruickshanks, KarenGEORGE WASHINGTON UNIVERSITY Epidemiology of Age-related Hearing LossDHHS, PHS, NIH Familial and Birth Cohort Effects on the Aging Senses

Danis, RonaldGEORGE WASHINGTON UNIVERSITY Diabetes Prevention Program Outcomes StudyWAKE FOREST UNIVERSITY Action to Control Cardiovascular Risk in Diabetes: ACCORD StudyGEORGE WASHINGTON UNIVERSITY Treatment Options for Type 2 Diabetes in Adolescents and YouthDHHS, PHS, NIH Ocular Complications of AIDS: Photograph Reading CenterDHHS, PHS, NIH Fundus Photograph Reading Center to Support a Multi-Center, Randomized Trial of Luetin, Zeaxanthin, and Omega-3 LCPUFAS in Age-Related Macular Edema (AREDS II)

Kalil, RonaldDOD, ARMY Does the Treatment of Breast Cancer with Adjuvant Chemotherapy Interfere with Hippocampal Neurogenesis and with Hippocampal-Dependent Cognitive Function?

Kaufman, PaulPFIZER, INC Regulation of outflow facility by gene transferUNIVERSITY OF NORTH CAROLINA Extra-Lenticular Aspects of Accommodation and PresbyopiaDHHS, PHS, NIH ARRA Aqueous humor dynamics studies in vivo and in vitro

Klein, BarbaraRRF Prevalence and Incident Changes in Retinal Vascular Caliber Associated with Medication and Supplement Use

Klein, RonaldADA American Diabetes Association - Mentor-Based Doctoral FellowshipADA The epidemiology of diabetic complicationsUNIVERSITY OF SOUTHERN CALIFORNIA Los Angeles Latino Eye Study

Klein, Ronald; Klein, BarbaraUNIVERSITY OF WASHINGTON Multi-Ethnic Study of Atherosclerosis (MESA II)DHHS, PHS, NIH Epidemiology of Age-Related Macular Degeneration and Other Retinal Diseases

Levin, LeonardRRH Pharmacological Protection Of Endothelial Cells For Retinal Vascular Disease

Mares, Julie; Blodi, Barbara; Chappell, Richard; Engelman, Corinne; Sarto, GloriaDHHS, PHS, NIH Diet and Lifestyle Factors Reducing Risk for Age-Related Eye Disease

McLellan, GillianDHHS, PHS, NIH Structural and functional characterization of a novel model for glaucoma research

Nickells, RobertDHHS, PHS, NIH Characterization of RGC death susceptibility allelesDHHS, PHS, NIH Molecular mechanism of retinal ganglion cell death

Sheibani, NaderADA CYP1B1, NF-kB , and Regulation of Angiogenesis DHHS, PHS, NIH PEDF and Diabetic RetinopathyDHHS, PHS, NIH PECAM-1 and Retinopathy of Prematurity

Sheibani, Nader; Assadi, Amir; Assadi-Porter, FaribaDHHS, PHS, NIH ARRA Integrated Multidisciplinary Strategies for Detection of Diabetic Retinopathies

Sheibani, Nader; Jefcoate, ColinDHHS, PHS, NIH ARRA CYP1B1 and Retinopathy of Prematurity

KEYFederal funding:NIH = National Institutes of Health

Foundation:ADA = American Diabetes AssociationAMA = American Medical AssociationJDRF = Juvenile Diabetes Research FoundationRRF = Retina Research Foundation

2010 SELECTED GRANTS


CLINICAL & RESEARCHFACULTY & STAFF 2010

Ivy J. Dreizin, MDAssociate Professor Neuro-ophthalmology

Richard E. Appen, MD Professor EmeritusNeuro-ophthalmology

Michael M. Altaweel, MDAssociate ProfessorRetina, vitreous, macula, ocular melanoma

Daniel M. Albert, MD, MSFrederick Allison Davis and Lorenz E. ZimmermanProfessor & Chair Emeritus Ocular oncology, ophthalmic pathology, comprehensive ophthalmology

Eugene D. Cropp, OD Clinical Optometrist Optometry

Ronald P. Danis, MDProfessor, Director of the Fundus PhotographReading Center Macular degeneration, diabetic retinopathy, retinal vascular diseases & posterior ocularinflammatory disorders

Janet Cushing, OD Clinical Optometrist Optometry

Karen J. Cruickshanks, PhD Professor Epidemiology of age-related ocular disorders, hearing loss, diabetes

Richard K. Dortzbach, MDProfessor EmeritusOphthalmic plastic & reconstructive surgery, surgical techniques

Matthew D. Davis, MD Professor Emeritus Vitreoretinal disease, diabetic retinopathy, clinical trials

Nansi Jo Colley, PhD Professor Molecular/genetic studies of retinal degeneration in Drosophila

Suresh R. Chandra, MD Professor Vitreoretinal disease, macular disease, ocular melanoma, trauma, international ophthalmology

Cat N. Burkat, MDAssistant ProfessorOphthalmic reconstructive & cosmetic surgery

Curtis R. Brandt, PhDProfessor Virology, cell & molecular biology, genetic mapping & recombinant techniques, gene therapy

Yasmin S. Bradfield, MDAssociate ProfessorPediatric ophthalmology & strabismus, retinopathy of prematurity, pediatric cataract surgery & intraocular lens implantation, pediatric eyelid surgery, pediatric glaucoma

Barbara A. Blodi, MD Professor Retinal diseases including macular degeneration and diabetic retinopathy

Neal P. Barney, MDAssociate ProfessorCornea & externaldisease, cornea & cataract surgery, uveitis, ocular immunology

Julia B. Agapov, MD, DOAssistant ProfessorGlaucoma, anterior segment & cataract surgery

Yonca O. Arat, MDAssistant ProfessorComprehensive ophthalmology, cataract surgery

David M. Gamm, MD, PhDAssistant ProfessorPediatric ophthalmology & strabismus, retinopathy of prematurity, pediatric cataract surgery & intraocular lens implantation, pediatric glaucoma

Thomas D. France, MDProfessor EmeritusPediatric ophthalmology & strabismus, amblyopia, visual function testing

Justin L. Gottlieb, MDAssociate ProfessorRetina, vitreous, macula

Gregg A. Heatley, MDAssociate ProfessorVice-Chair/ClinicalGlaucoma, anterior segment & cataract surgery

Celeste K. Jend, ODClinical OptometristOptometry

Michael S. Ip, MDAssociate ProfessorVitreoretinal surgery for diabetic retinopathy and retinal detachment, treatment of age-related macular degeneration, clinical trials research

Ronald E. Kalil, PhDProfessorNeural cell death & repair after brain damage

Paul L. Kaufman, MDPeter A. Duehr Professor & ChairGlaucoma, aqueous humor dynamics, anterior segment physiology & pharmacology, presbyopia

Barbara E.K. Klein, MD, MPHProfessorGlaucoma, comprehensive ophthalmology, cataracts, diabetic retinopathy, epidemiology, preventive medicine

Michael J. Feifarek, MD InstructorComprehensive ophthalmology

Ronald Klein, MD, MPHProfessorVitreoretinal disease, diabetic retinopathy,age-related eye diseases, epidemiology


Thomas S. Stevens, MDProfessorVitreoretinal disease, macular disease, diabetic retinopathy, proliferative vitreoretinopathy

Todd W. Perkins, MDProfessorGlaucoma, normal tension glaucoma, implant devices, cataract surgery

Heather A.D. Potter, MDAssistant ProfessorComprehensive ophthalmology, ophthalmic pathology,cataract surgery , refractive surgery

Arthur S. Polans, PhDProfessor Cancer-related ocular pathologies

Stephen K. Sauer, MDAssistant ProfessorResidency DirectorComprehensive ophthalmology, cataract surgery

Patricia C. Sabb, MDAssistant ProfessorComprehensive ophthalmology, cataract surgery, refractive surgery

Nader Sheibani, PhDAssociate ProfessorDiabetic retinopathy, retinopathy of prematurity, animal models and retinal vascular cell biology and signal transduction

Richard W. Patterson, ODClinical OptometristOptometry

Cameron F. Parsa, MDAssociate ProfessorPediatric ophthalmology and strabismus, neuro-ophthalmology

Gary W. Sterken, MDAssistant ProfessorComprehensive ophthalmology, cataract surgery, glaucoma

T. Michael Nork, MD, MSAssociate ProfessorDiseases & surgery of the retina & vitreous

Burton J. Kushner, MDProfessorPediatric ophthalmology & strabismus, amblyopia, surgical techniques

Julie A. Mares, PhDProfessorEpidemiology of eye disease, nutritional epidemiology

Mark J. Lucarelli, MDProfessorOculoplastic, cosmetic facial and orbital surgery

Leonard A. Levin, MD, PhDProfessorNeuro-ophthalmology, ganglion cell death

Daniel W. Knoch, MDAssistant ProfessorComprehensive ophthalmology, cataract surgery

Michele M. Martin, ODClinical OptometristOptometry

Robert W. Nickells, PhDProfessor Vice-Chair/ResearchMolecular biology of cell death in glaucoma & retinoblastoma

Sarah M. Nehls, MDAssistant Professor Vice-Chair/CME & Faculty DevelopmentRefractive surgery, cornea & external disease, cornea & cataract surgery, uveitis

Aparna Lakkaraju, PhDAssistant ProfessorRetinal cell biology, pathogenesis of retinal degenerations,identification of therapeutic targets

Amy L. Walker, ODClinical OptometristOptometry

James N. Ver Hoeve, PhDSenior ScientistVisual electrophysiology

Norbert F. Toussaint, Jr., MDAssistant ProfessorComprehensive ophthalmology

Andrew T. Thliveris, MD, PhDAssociate Professor Assistant Residency DirectorChief of Ophthalmology William S. Middleton Memorial Veterans Hospital Comprehensive ophthalmology, cataracts, ocular genetics

John E. Temprano, MDAssociate ProfessorComprehensive ophthalmology, cataract surgery

Michael C. Struck, MDAssociate ProfessorPediatric ophthalmology & strabismus, retinopathy of prematurity, pediatric cataract surgery & intraocular lens implantation, pediatric glaucoma

Frank L. Myers, MDProfessor Retina


2010 CLINICAL TRIALSA Natural History Study of Macular Telangiectasia: The Mactel Study – Mactel

Principal Investigator: Barbara A. Blodi, MD

Study Coordinator: Michelle R. (Shelly) Olson

Synopsis:

This study is a prospective, cross-sectional study of participants with a diagnosis of macular telangiectasia.

Age-Related Eye Disease Study 2 (AREDS 2)

Principal Investigators: Suresh R. Chandra, MD, and Barbara A. Blodi, MD

Study Coordinator: Michelle R. (Shelly) Olson

Synopsis:

A multi-center, randomized trial of lutein, zeaxanthin, and omega-3 long-chain polyunsaturated fatty acids [docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)] in age-related macular degeneration (AMD).

Comparison of AMD Treatment Trials (CATT) Lucentis – Avastin Trial

Principal Investigators: Suresh R. Chandra, MD and Michael M. Altaweel, MD

Study Coordinators: Kristine A. Dietzman, Angie M. Wealti, Jennie R. Perry-Raymond

Synopsis:

This study seeks to evaluate the relative efficacy and safety of treatment of subfoveal neovascular AMD with Lucentis on a fixed schedule, Avastin on a fixed schedule, Lucentis on a variable schedule, and Avastin on a variable schedule.

CNV Secondary to AMD Treated with Beta RadiatioN Epiretinal Therapy – NeoVista Inc. (CABERNET): NV1-114 Randomized, Prospective, Controlled Study of the NeoVista System for the Treatment of Subfoveal Choroidal Neovascularization Associated with Wet AMD

Principal Investigator: Michael S. Ip, MD

Study Coordinators: Kristine A. Dietzman and Guy F. Somers, RN

Synopsis:

The objective of the CABERNET Trial is to evaluate the safety and efficacy of focal delivery of radiation for the treatment of subfoveal choroidal neovascularization (CNV) associated with wet age-related macular degeneration (AMD).

Diabetic Retinopathy Clinical Research Network (DRCR)

Synopsis:

STUDY I: Intravitreal Ranibizumab or Triamcinolone Acetonide in Combination with Laser Photocoagulation for Diabetic Macular Edema

Principal Investigator: Justin L. Gottlieb, MD

Study Coordinator: Kathryn F. Burke

Synopsis:

The purpose of the study is to compare: 1) sham injection plus laser treatment; 2) injection of intravitreal ranibizumab (Lucentis) plus laser treatment; 3) injection of intravitreal ranibizumab plus deferred (or delayed) laser treatment; or 4) injection of intravitreal triamcinolone plus laser treatment. It is a three-year study with follow-up every four weeks.

Molecular Prognostic Assay for Uveal Melanoma

Principal Investigator: Michael M. Altaweel, MD

Study Coordinator: Guy F. Somers, RN

Synopsis:

This study will investigate the accuracy of a molecular test for predicting metastasis in uveal melanoma patients. This may lead to better prognostic testing and prophylactic treatment for high-risk patients.

OPHTEC – Model 311 Artificial Iris Lens for the Treatment of Visual Disturbances Resulting from Partial or Total Absence of the Human Iris: Continued Access Compassionate Use Study


Study Coordinators: Kristine A. Dietzman, Jennie R. Perry-Raymond

Synopsis:

OPHTEC’s Model 311 Artificial Iris Intraocular Lens is a unique, single-piece lens manufactured from colored, ultraviolet light absorbing polymethylmethacrylate (PMMA). The lens is designed for implantation into an aphakic human eye for the correction of visual disturbances resulting from an incomplete or totally absent iris and the correction of the spherical refractive error as necessary.

Regeneron: A Randomized, Double Masked, Active Controlled Phase III Study of the Efficacy, Safety, and Tolerability of Repeated Doses of Intravitreal VEGF Trap in Subjects with Neovascular Age- Related Macular Degeneration (VGFT-OD-0605)


Study Coordinators: Angie M. Wealti, Kristine A. Dietzman, Jennie R. Perry-Raymond

Synopsis:

The purpose of this study is to assess the efficacy


of intravitreal (ITV) administered VEGF Trap compared to ranibizumab in a non-inferiority paradigm in preventing moderate vision loss in subjects with all subtypes of neovascular AMD.

SK MD7110852 EYE DROP STUDY (A Phase 2b Dose-Ranging Study of Pazopanib Eye Drops versus Ranibizumab Intravitreal Injections for the Treatment of Neovascular Age-Related Macular Degeneration)


Study Coordinator: Angie R. Wealti

Synopsis:

A multicenter, randomized, parallel-group, double-masked eye drops, and active-controlled study. In addition to 5 investigational daily-dosed pazopanib eye drop arms, there will be two additional treatment arms.

PEDIG ~ Intermittent Exotropia Study 1. A Randomized Trial of Bilateral Lateral Rectus Recession versus Unilateral Lateral Rectus Recession with Medial Rectus Resection for Intermittent Exotropia

Principal Investigator: Yasmin S. Bradfield, MD

Study Coordinator: Barbara H. Soderling, Guy F. Somers, RN

Synopsis:

To evaluate the effectiveness of bilateral lateral rectus muscle recession versus unilateral lateral rectus recession with medial rectus resection procedures for the treatment of basic type and pseudo divergence excess type intermittent exotropia.

Randomization (1:1) to surgical correction of IXT with a bilateral lateral rectus recession (BLRrec) or a unilateral lateral rectus recession with medial rectus resection (R&R).

Home Vision Monitoring in AREDS2 for Progression to NeoVascular AMD Using the ForeseeHome Device

Principal Investigator: Suresh R. Chandra, MD and Barbara A. Blodi, MD

Study Coordinator: Kathryn F. Burke

Synopsis:

The overall objective of this two-arm randomized clinical trial is to determine if home monitoring using the comprehensive visual field and telemedicine solution based on the ForeseeHome device in AREDS2 for participants at high risk of progression to neovascular AMD improves detection of progression to choroidal neovascularization (CNV) when compared with standard care.

ALCON C-10-004. A Phase 3B, Multicenter, Randomized, Double-Masked, Parallel-Group, Active-Controlled Study of the Safety and Efficacy of Difluprednate Ophthalmic Emulsion, 0.05% 4 times daily and Prednisolone Acetate Ophthalmic Suspension, 1.0% 4 times daily for the Treatment of Inflammation Following Cataract Surgery in children 0 to 3 years of age

Principal Investigator: Michael C. Struck, MD Sub-Investigator: Yasmin S. Bradfield, MD

Study Coordinators: Guy F. Somers, RN, Barbara H. Soderling

Synopsis:

To compare, in a pediatric population 0 to 3 years of age, the safety and efficacy of Durezol and Pred Forte for the treatment of inflammation following cataract surgery.

OPHTHOTECH CORP Protocol no: OPH1001. A Phase 2, Randomized, Double-Masked, Controlled Trial to Establish the Safety and Efficacy of Intravitreous Injections of E10030 (Anti-PDGF Pegylated Aptamer) Given in Combination with Lucentis in Subjects with Neovascular Age-Related Macular Degeneration


Study Coordinator: Barbara H. Soderling

Synopsis:

The objectives of this study are to evaluate the safety and efficacy of E10030 intravitreous injection when administered in combination with Lucentis against a control of Lucentis alone in subjects with subfoveal choroidal neovascularization secondary to age-related macular degeneration (AMD).

Evaluation of Possible Toxicity of Indocyanine Green Dye in Macular Hole Surgery Using Multifocal Electroretinogram


Student Researcher: Amol Kulkarni, MD

Study Coordinator: Barbara H. Soderling

Synopsis:

The purpose of the research is to test the nerve cells in the retina by MERG to determine if there are any differences by using conventional (1 mg/ml) versus low dose (0.5 mg/ml) of ICG during macular hole surgery.

Duration: This pilot study will last no longer than 6-months for each subject. Recruitment will likely be complete within 8 months of study start date. The data analysis will be performed at the end of the study. It is expected that the study will be completed and the results will be available within 18 months from the time of commencement.

Outcome measures:

Primary: Retinal response density as measured by mfERG at 6-month post-operative visit to evaluate for retinal toxicity. Secondary: Best corrected snellen visual acuity (BCVA), and optical coherence tomography (OCT) evidence of hole closure in the operated eye.


2010 PUBLICATIONSAiello LP, Edwards AR, Beck RW, Bressler NM, Davis MD, Ferris F, Glassman AR, Ip MS, Miller KM. Factors associated with improvement and worsening of visual acuity 2 years after focal/grid photocoagulation for diabetic macular edema. Ophthalmology. 2010 May;117(5):946-53.

Albert DM, Atzen SL, Morgan P. The practice of ophthalmology in rural Wisconsin in the mid-19th century: from the casebooks of Francis Paddock, MD. Arch Ophthalmol. 2010 Jun;128(6):783-8.

Albert DM, Neekhra A, Wang S, Darjatmoko SR, Sorenson CM, Dubielzig RR, Sheibani N. Development of choroidal neovascularization in rats with advanced intense cyclic light-induced retinal degeneration. Arch Ophthalmol. 2010 Feb;128(2):212-22.

Altmann S, Emanuel A, Toomey M, McIntyre K, Covert J, Dubielzig RR, Leatherberry G, Murphy CJ, Kodihalli S, Brandt CR. A quantitative rabbit model of vaccinia keratitis. Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4531-40.

Altmann S, Toomey M, Nesbit B, McIntyre K, Covert J, Dubielzig RR, Leatherberry G, Adkins E, Murphy CJ, Brandt CR. Kinetics of immune cell infiltration in vaccinia virus keratitis. Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4541-8.

Ambrosius WT, Danis RP, Goff DC Jr, Greven CM, Gerstein HC, Cohen RM, Riddle MC, Miller ME, Buse JB, Bonds DE, Peterson KA, Rosenberg JD, Perdue LH, Esser BA, Seaquist LA, Felicetta JV, Chew EY; ACCORD Study Group. Lack of association between thiazolidinediones and macular edema in type 2 diabetes; the ACCORD eye substudy. Arch Ophthalmol. 2010 Mar;128(3):312-8.

Blodi BA, Domalpally A, Scott IU, Ip MS, Oden NL, Elledge J, Warren K, Altaweel MM, Kim JE, Van Veldhuisen PC. Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study system for evaluation of stereoscopic color fundus photographs and fluorescein angiograms: SCORE Study Report 9. Arch Ophthalmol. 2010 Sep;128(9):1140-5.

Boosani CS, Nalabothula N, Sheibani N, Sudhakar A. Inhibitory effects of arresten on bFGF-induced proliferation, migration, and matrix metalloproteinase-2 activation in mouse retinal endothelial cells. Curr Eye Res. 2010 Jan;35(1):45-55.

Bradfield Y. Vision screening to detect refractive error. JAMA. 2010 Sep 8; 304(10):1114-5.

Buie LK, Rasmussen CA, Porterfield EC, Ramgolam VS, Choi VW, Markovic-Plese S, Samulski RJ, Kaufman PL, Borras T. Self-complementary AAV virus (scAAV) safe and long-term gene transfer in the trabecular meshwork of living rats and monkeys. Invest Ophthalmol Vis Sci. 2010 Jan;51(1):236-48.

Bultmann H, Girdaukas G, Kwon GS, Brandt CR. The virucidal EB peptide protects host cells from herpes simplex virus type 1 infection in the presence of serum albumin and aggregates proteins in a detergent-like manner. Antimicrob Agents Chemother. 2010 Oct;54(10):4275-89.

Candia OA, Kaufman PL. Remembering Steven M. Podos, MD, 1937-2009. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1261-2.

Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Corton M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7401-6.

Cheng CY, Lee KE, Duggal P, Moore EL, Wilson AF, Klein R, Bailey-Wilson JE, Klein BE. Genome-wide linkage analysis of multiple metabolic factors: evidence of genetic heterogeneity. Obesity (Silver Spring) 2010 Jan;18(1):146-52.

Cheng CY, Reich D, Wong TY, Klein R, Klein BE, Patterson N, Tandon A, Li M, Boerwinkle E, Sharrett AR, Kao WH. Admixture mapping scans identify a locus affecting retinal vascular caliber in hypertensive African Americans: the Atherosclerosis Risk in Communities (ARIC) study. PLoS Genet. 2010 Apr 15;6(4):e1000908.

Chew EY, Ambrosius WT, Davis MD, Danis RP, Gangaputra S, Greven CM, Hubbard L, Esser BA, Lovato JF, Perdue LH, Goff DC, Jr., Cushman WC, Ginsberg HN, Elam MB, Genuth S, Gerstein HC, Schubart U, Fine LJ. Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med. 2010 Jul 15;363(3):233-44.

Chew EY, Kim J, Coleman HR, Aiello LP, Fish G, Ip M, Haller JA, Figueroa M, Martin D, Callanan D, Avery R, Hammel K, Thompson D, Ferris FL. Preliminary assessment of celecoxib and microdiode pulse laser treatment of diabetic macular edema. Retina. 2010 Mar;30(3):459-67.

Chew EY, Kim J, Sperduto RD, Datiles MB 3rd, Coleman HR, Thompson DJ, Milton RC, Clayton JA, Hubbard LD, Danis RP, Ferris FL 3rd. Evaluation of the age-related eye disease study clinical lens grading system AREDS report No. 31. Ophthalmology. 2010 Nov;117(11):2112-9.

Danis RP, Scott IU, Qin H, Altaweel MM, Bressler NM, Bressler SB, Browning DJ, Kollman C. Association of fluorescein angiographic features with visual acuity and with optical coherence tomographic and stereoscopic color fundus photographic features of diabetic macular edema in a randomized clinical trial. Retina. 2010 Nov-Dec;30(10):1627-37.

Diabetic Retinopathy Clinical Research Network Writing Committee, Haller JA, Qin H, Apte RS, Beck RR, Bressler NM, Browning DJ, Danis RP, Glassman AR, Googe JM, Kollman C, Lauer AK, Peters MA, Stockman ME. Vitrectomy outcomes in eyes with diabetic macular edema and vitreomacular traction. Ophthalmology. 2010 Jun;117(6):1087-1093.


Domalpally A, Danis RP, Myers D, Kruse CN. Quantitative analysis of the Stratus optical coherence tomography fast macular thickness map reports. Indian J Opthalmol. 2010 Mar-Apr;58(2):131-6.

Domalpally A, Gangaputra S, Peng Q, Danis RP. Repeatability of retinal thickness measurements between spectral-domain and time-domain optical coherence tomography images in macular disease. Ophthalmic Surg Lasers Imaging. 2010 Nov-Dec;41 Suppl:S34-41.

Dutta D, Ray S, Home P, Saha B, Wang S, Sheibani N, Tawfik O, Cheng N, Paul S. Regulation of angiogenesis by histone chaperone HIRA-mediated incorporation of lysine 56-acetylated histone H3.3 at chromatin domains of endothelial genes. J Biol Chem. 2010 Dec 31;285(53):41567-77.

France TD. Charlie Brown, amblyopia, and me: A (not so short) personal history of the past forty years of diagnosing and treating amblyopia. Am Orthopt J. 2010;60:73-81.

Fu YP, Hallman DM, Gonzalez VH, Klein BE, Klein R, Hayes MG, Cox NJ, Bell GI, Hanis CL. Identification of diabetic retinopathy genes through a genome-wide association study among Mexican-Americans from Starr County, Texas. J Ophthalmol. 2010; 2010. pii:86129

Gamm DM, Meyer JS. Directed differentiation of human induced pluripotent stem cells: a retina perspective. Regen Med. 2010 May; (3):315-7.

Grutzmacher C, Park S, Elmergreen TL, Tang Y, Scheef EA, Sheibani N, Sorenson CM. Opposing effects of bim and bcl-2 on lung endothelial cell migration. Am J Physiol Lung Cell Mol Physiol. 2010 Nov;299(5):L607-20.

Havas DA, Glenberg AM, Gutowski KA, Lucarelli MJ, Davidson RJ. (2010) Cosmetic use of botulinum toxin-a affects processing of emotional language. Psychol Sci. 2010 Jul; 21(7):895-900.

Hwang FS, Neekhra A, Lucarelli MJ, Warner TF, Snow SN, Albert DM. Sebaceous cell carcinoma of the eyelid: a rapidly enlarging lesion with massive xanthogranulomatous inflammation. Ophthal Plast Reconstr Surg. 2010 May-Jun;26(3):208-10.

Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, Wang JJ, Klein R, Klein BE, Breteler MM, Cheung N, Liew G, Mitchell P, Uitterlinden AG, Rivadeneira F, Hofman A, de Jong PT, van Duijn CM, Kao L, Cheng CY, Smith AV, Glazer NL, Lumley T, McKnight B, Psaty BM, Jonasson F, Eiriksdottir G, Aspelund T, Harris TB, Launer LJ, Taylor KD, Li X, Iyengar SK, Xi Q, Sivakumaran TA, Mackey DA, Macgregor S, Martin NG, Young TL, Bis JC, Wiggins KL, Heckbert SR, Hammond CJ, Andrew T, Fahy S, Attia J, Holliday EG, Scott RJ, Islam FM, Rotter JI, McAuley AK, Boerwinkle E, Tai ES, Gudnason V, Siscovick DS, Vingerling JR, Wong TY. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. PLoS Genet. 2010 Oct 28;6(10):e1001184.

Ip MS. What do I do when I see a patient with a branch retinal vein occlusion and what are the treatment options? In: Fekrat S, ed, Curbside Consultation in Retina. Slack Inc, Thorofare, NJ, pp.131-134, 2010.

Jensen K, Lee KE, Knudtson MD, Klein R, Klein BE. Stability of 35-mm scanners as used in ophthalmologic research. Ophthalmic Surg Lasers Imaging. 2010 Jan-Feb; 41(1):60-6.

Jensen RA, Shea S, Ranjit N, Diez-Roux A, Wong TY, Klein R, Klein BE, Cotch MF, Siscovick DS. Psychosocial risk factors and retinal microvascular signs: the multi-ethnic study of atherosclerosis. Am J Epidemiol. 2010 Mar 1;171(5):522-31.

Kaufman PL. Suppression and reduction of corticosteroid-induced ocular hypertension by anecortave in sheep. Arch Ophthalmol. 2010 Mar;128(3):365-6.

Kempen JH, Altaweel MM, Holbrook JT, Jabs DA, Sugar EA. The multicenter uveitis steroid treatment trial: rationale, design, and baseline characteristics. Am J Ophthalmol. 2010 Apr;149(4):550-61 e10.

Kern TS, Du Y, Miller CM, Hatala DA, Levin LA. Overexpression of Bcl-2 in vascular endothelium inhibits the microvascular lesions of diabetic retinopathy. Am J Pathol. 2010 May;176(5):2550-8.

Klein BE, Lee KE, Danforth LG, Schaich TM, Cruickshanks KJ, Klein R. Selected sun-sensitizing medications and incident cataract. Arch Ophthalmol. 2010 Aug;128(8):959-63.

Klein BE, Lee KE, Moss SE, Trentham-Dietz A, Klein R. Self- and registry-reported cancer in a population-based longitudinal study. WMJ. 2010 Oct;109(5):261-6.

Klein BE, Meuer SM, Lee KE, Klein R. Retrodots in the lens in the Beaver Dam Eye Study cohort. Ophthalmology. 2010 Oct;117(10):1889-93.

Klein BE. Progression of retinopathy in persons with type 2 diabetes: new data, same conclusions? Pol Arch Med Wewn. 2010 Oct;120(10):413-6.

Klein BE. Reduction in risk of progression of diabetic retinopathy. N Engl J Med. 2010 Jul 15;363(3):287-8.

Klein R, Blodi BA, Meuer SM, Myers CE, Chew EY, Klein BE. The prevalence of macular telangiectasia type 2 in the Beaver Dam eye study. Am J Ophthalmol. 2010 Jul;150(1):55-62 e2.

Klein R, Cruickshanks KJ, Nash SD, Krantz EM, Javier Nieto F, Huang GH, Pankow JS, Klein BE. The prevalence of age-related macular degeneration and associated risk factors. Arch Ophthalmol. 2010 Jun;128(6):750-8.

Klein R, Klein BE. Are individuals with diabetes seeing better?: a long-term epidemiological perspective. Diabetes. 2010 Aug;59(8):1853-60.

Klein R, Knudtson MD, Klein BE, Wong TY, Cotch MF, Barr G. Emphysema, airflow limitation, and early age-related macular degeneration. Arch Ophthalmol. 2010 Apr;128(4):472-7.


2010 PUBLICATIONSKlein R, Knudtson MD, Klein BE, Zinman B, Gardiner R, Suissa S, Sinaiko AR, Donnelly SM, Goodyer P, Strand T, Mauer M. The relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes. Diabtologia. 2010 Aug;53(8):1638-46.

Klein R, Lee KE, Gangnon RE, Klein BE. The 25-year incidence of visual impairment in type 1 diabetes mellitus: The Wisconsin epidemiologic study of diabetic retinopathy. Ophthalmology. 2010 Jan;117(1):63-70.

Klein R, Myers CE, Klein BE, Zinman B, Gardiner R, Suissa S, Sinaiko AR, Donnelly SM, Goodyer P, Strand T, Mauer M. Relationship of blood pressure to retinal vessel diameter in type 1 diabetes mellitus. Arch Ophthalmol. 2010 Feb;128(2):198-205.

Kopplin LJ, Igo RP, Jr., Wang Y, Sivakumaran TA, Hagstrom SA, Peachey NS, Francis PJ, Klein ML, Sangiovanni JP, Chew EY, Pauer GJ, Sturgill GM, Joshi T, Tian L, Xi Q, Henning AK, Lee KE, Klein R, Klein BE, Iyengar SK. Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. Genes Immun. 2010 Dec; 11(8):609-21.

Krantz EM, Cruickshanks KJ, Klein BE, Klein R, Huang GH, Nieto FJ. Measuring refraction in adults in epidemiological studies. Arch Ophthalmol. 2010 Jan;128(1):88-92.

Kraus A, Groenendyk J, Bedard K, Baldwin TA, Krause KH, Dubois-Dauphin M, Dyck J, Rosenbaum EE, Korngut L, Colley NJ, Gosgnach S, Zochodne D, Todd K, Agellon LB, Michalak M. Calnexin deficiency leads to dysmyelination. J Biol Chem. 2010 Jun 11;285(24):18928-38.

Kushner BJ. In memoriam: Arthur L. Rosenbaum, MD (1940-2010). Arch Ophthalmol. 2010 Oct;128(10):1383.

Larsen IV, Brandt CR. A cationic TAT peptide Inhibits Herpes simplex virus type 1 Infection of human corneal epithelial cells. J Ocul Pharmacol Ther. 2010 Dec;26(6):541-7.

Lee ES, Gabelt BT, Faralli JA, Peters DM, Brandt CR, Kaufman PL, Bhattacharya SK. COCH transgene expression in cultured human trabecular meshwork cells and its effect on outflow facility in monkey organ cultured anterior segments. Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2060-6.

Li HK, Florez-Arango JF, Hubbard LD, Esquivel A, Danis RP, Krupinski EA. Grading diabetic retinopathy severity from compressed digital retinal images compared with uncompressed images and film. Retina. 2010 Nov-Dec;30(10):1651-61.

Li HK, Hubbard LD, Danis RP, Esquivel A, Florez-Arango JF, Ferrier NJ, Krupinski EA. Digital versus film Fundus photography for research grading of diabetic retinopathy severity. Invest. Ophthalmol Vis Sci. 2010 Nov;51(11):5846-52.

Li HK, Hubbard LD, Danis RP, Esquivel A, Florez-Arango JF, Krupinski EA. Monoscopic versus stereoscopic retinal photography for grading diabetic retinopathy severity. Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3184-92.

Li HK, Hubbard LD, Danis RP, Florez-Arango JF, Esquivel A, Krupinski EA. Comparison of multiple stereoscopic and monoscopic digital image formats to film for diabetic macular edema evaluation. Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6753-61.

Lichtlen P, Lam TT, Nork TM, Streit T, Urech DM. Relative contribution of VEGF and TNF-alpha in the cynomolgus laser-induced CNV model: comparing the efficacy of bevacizumab, adalimumab, and ESBA105. Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4738-45.

Lu B, Wang S, Francis PJ, Li T, Gamm DM, Capowski EE, Lund RD. Cell transplantation to arrest early changes in an ush2a animal model. Invest Ophthalmol Vis Sci. 2010 Apr; 51(4):2269-76.

Lutjen-Drecoll E, Kaufman PL, Wasielewski R, Ting-Li L, Croft MA. Morphology and accommodative function of the vitreous zonule in human and monkey eyes. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1554-64.

Mares JA, Voland R, Adler R, Tinker L, Millen AE, Moeller SM, Blodi B, Gehrs KM, Wallace RB, Chappell RJ, Neuhouser ML, Sarto GE. Healthy diets and the subsequent prevalence of nuclear cataract in women. Arch Ophthalmol. 2010 Jun;128(6):738-49.

Nema N, Ip MS. Intravitreal triamcinolone for management of idiopathic juxtafoveolar telangiectasis. Oman J Ophthalmol. 2010 Jan;3(1):38-40.

Nguyen TT, Islam FM, Farouque HM, Klein R, Klein BE, Cotch MF, Herrington DM, Wong TY. Retinal vascular caliber and brachial flow-mediated dilation: the Multi-Ethnic Study of Atherosclerosis. Stroke. 2010 Jul;41(7):1343-8.

Nickells RW. Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Exp Eye Res. 2010 Jul;91(1):2-8.

Nondahl DM, Cruickshanks KJ, Wiley TL, Klein BE, Klein R, Chappell R, Tweed TS. The ten-year incidence of tinnitus among older adults. Int J Audiol. 2010 Aug;49(8):580-5.

Nork TM, Kim CB, Heatley GA, Kaufman PL, Lucarelli MJ, Levin LA, Ver Hoeve JN. Serial multifocal electroretinograms during long-term elevation and reduction of intraocular pressure in non-human primates. Doc Ophthalmol. 2010 Jun;120(3):273-89.

Oden NL, VanVeldhuisen PC, Scott IU, Ip MS; SCORE Study Investigator Group. SCORE Study Report 8: Closed tests for all pairwise comparisons of means. Drug Information Journal (DIA). 2010;44:405-20.

Pariseau B, Nehls S, Ogawa GS, Sutton DA, Wickes BL, Romanelli AM. Beauveria keratitis and biopesticides: case histories and a random amplification of polymorphic DNA comparison. Cornea 2010 Feb;29(2):152-8.

Park S, Dimaio TA, Scheef EA, Sorenson CM, Sheibani N. PECAM-1 regulates the proangiogenic properties of endothelial cells through modulation of cell-cell and cell-matrix interactions. Am J Physiol Cell Physiol. 2010 Dec;299(6):C1468-84.


Pelzel HR, Schlamp CL, Nickells RW. Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis. BMC neurosci. 2010 May 26;11:62.

Puhan MA, Van Natta ML, Palella FJ, Addessi A, Meinert C. Excess mortality in patients with AIDS in the era of highly active antiretroviral therapy: temporal changes and risk factors. Clin Infect Dis. 2010 Oct 15;51(8):947-56.

Recchia FM, Scott IU, Brown GC, Brown MM, Ho AC, Ip MS. Small-gauge pars plana vitrectomy: a report by the American Academy of Ophthalmology. Ophthalmology. 2010 Sep;117(9):1851-7.

Sahakyan K, Klein BE, Lee KE, Tsai MY, Klein R. Inflammatory and endothelial dysfunction markers and proteinuria in persons with type 1 diabetes mellitus. Eur J Endocrinol. 2010 Jun;162(6):1101-5.

Sahakyan K, Klein BE, Myers CE, Tsai MY, Klein R. Novel risk factors in long-term hypertension incidence in type 1 diabetes mellitus. Am. Heart J. 2010 Jun;159(6):1074-80.

Schwinn MK, Gonzalez JM, Jr., Gabelt BT, Sheibani N, Kaufman PL, Peters DM. Heparin II domain of fibronectin mediates contractility through an alpha4beta1 co-signaling pathway. Exp Cell Res. 2010 May 15;316(9):1500-12.

Scott CJ, Seidler EA, Levin LA. Cell-autonomous generation of mitochondrial superoxide is a signal for cell death in differentiated neuronal precursor cells. Brain Res. 2010 Jan 8;1306:142-8.

Seidler EA, Lieven CJ, Thompson AF, Levin LA. Effectiveness of novel borane-phosphine complexes in inhibiting cell death depends on the source of superoxide production induced by blockade of mitochondrial electron transport. ACS Chem Neurosci. 2010 Feb 17;1(2):95-103.

Semaan SJ, Li Y, Nickells RW. A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death. ASN Neuro. 2010 Mar 31;2(2):e00032.

Semaan SJ, Nickells RW. The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein. BMC Cancer. 2010 Oct 13;10(1):554.

Shankar A, Lee KE, Klein BE, Muntner P, Brazy PC, Cruickshanks KJ, Nieto FJ, Danforth LG, Schubert CR, Tsai MY, Klein R. Estimating glomerular filtration rate in a population-based study. Vasc Health Risk Manag. 2010 Aug 9;6:619-27.

Sharma A, Yu C, Leung C, Trane A, Lau M, Utokaparch S, Shaheen F, Sheibani N, Bernatchez P. A new role for the muscle repair protein dysferlin in endothelial cell adhesion and angiogenesis. Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2196-204.

Sprague BL, Skinner HG, Trentham-Dietz A, Lee KE, Klein BE, Klein R. Serum calcium and breast cancer risk in a prospective cohort study. Ann Epidemiol. 2010 Jan;20(1):82-5.

Struck MC, Hariharan L, Kushner BJ, Bradfield Y, Hetzel S. Surgical management of clinically significant hypertropia associated with exotropia. J AAPOS. Jun;14(3):216-20.

Subramanian L, Youssef S, Bhattacharya S, Kenealey J, Polans AS, van Ginkel PR. Resveratrol: challenges in translation to the clinic - a critical discussion. Clin Cancer Res. 2010 Dec 15;16(24):5942-8.

Talahalli R, Zarini S, Sheibani N, Murphy RC, Gubitosi-Klug RA. Increased synthesis of leukotrienes in the mouse model of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1699-708.

Tan JC, Kiland JA, Gonzalez JM, Gabelt BT, Peters DM, Kaufman PL. Sodium orthovanadate effect on outflow facility and intraocular pressure in live monkeys. Exp Eye Res. 2010 Oct;91(4):486-90.

Tang Y, Scheef EA, Gurel Z, Sorenson CM, Jefcoate CR, Sheibani N. CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress. Am J Physiol Cell Physiol. 2010 Mar;298(3):C665-78.

Thompson AF, Levin LA. Neuronal differentiation by analogs of staurosporine. Neurochem Int. 2010 Mar; 56(4):554-60.

Tian B, Heatley GA, Filla MS, Kaufman PL. Effect of h-7 on secondary cataract after phacoemulsification in the live rabbit eye.J Ocul Pharmacol Ther. 2010 Dec;26(6):533-9.

White NH, Sun W, Cleary PA, Tamborlane WV, Danis RP, Hainsworth DP, Davis MD. Effect of prior intensive therapy in type 1 diabetes on 10-year progression of retinopathy in the DCCT/EDIC: comparison of adults and adolescents. Diabetes 2010 May;59(5):1244-53.

Yan Y, Klein R, Heiss G, Girman CJ, Lange EM, Klein BE, Rose KM, Boerwinkle E, Pankow JS, Brancati FL, Ballantyne CM, Kottgen A, North KE. The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study. BMC Endocr Disord. 2010 May 17;10: 9.

Yatsuya H, Folsom AR, Wong TY, Klein R, Klein BE, Sharrett AR. Retinal microvascular abnormalities and risk of lacunar stroke: Atherosclerosis Risk in Communities Study. Stroke. 2010 Jul;41(7):1349-55.

Zhan W, Cruickshanks KJ, Klein BE, Klein R, Huang GH, Pankow JS, Gangnon RE, Tweed TS. Generational differences in the prevalence of hearing impairment in older adults. Am J Epidemiol. 2010 Jan 15;171(2):260-6.

Zhang X, Saaddine JB, Chou CF, Cotch MF, Cheng YJ, Geiss LS, Gregg EW, Albright AL, Klein BE, Klein R. Prevalence of diabetic retinopathy in the United States, 2005-2008. JAMA. 2010 Aug 11;304(6):649-56.

Zhong W, Cruickshanks KJ, Schubert CR, Nieto FJ, Huang GH, Klein BE, Klein R. Obesity and depression symptoms in the Beaver Dam Offspring Study population. Depress Anxiety. 2010 Sep; 27(9):846-51.


2010 DONOR HONOR ROLL$100,000+Daniel M. and Eleanor AlbertRetina Research FoundationUniversity of WI Medical Fdtn

$10,000-99,999Nancy ChowSarah E. Slack Prevention of Blindness

$5,000-9,999Covance Laboratories North AmericaOSOD LLC

$1,000-4,999James C. AllenCharles J. ChvalaMatthew D. DavisDavid E. GroszWendell A. HarkerNewell D. and Helen JaspersonAlbert V. and Dolores H. KannerIrving E. LevyJeffrey C. LevyRonald L. and Jean L. LewisMark F. MergenT. Michael NorkMary V. H. PrattWanda L. RoodIsolde SchweglerBryan S. SiresCasmir Turnquist-HeldAmy L. WalkerLucille M. WarrenRobert G. and Carol A. WittAudrey A. Yahr

$500-999Robert V. Castrovinci and Kay E. RutlinMichelle E. ChizekGregg A. HeatleyMichael J. Long

David P. and Cathrine Mc CannMerle L. and Barbara PerkinsHarry and Karen M. RothGregory A. StainerRobin S. WilsonWittenberg Lions Club

<$500Julia AgapovNeil E. and Carol J. AikenBud and Betty AlbrechtDick and Virginia AndersonBernice E. BanksLaurie S. BensonDonna M. BischoffH. Jane BlackmanJeff and Nancy W. BocherG. Andrew BoushChristine BraaschRandy and Susan B. BradenPaul M. BruskyThomas G. and Suzan L. BureshJim and Connie CarwardineRichard E. ChamberlinArnold L. and Kay E. ClementVirginia ConwayPatricia A. CosgroveSteve and Mary CraigKathy A. CrandallMichael L. CrookEarl W. and Linda T. CruzanRobert S. CullenBruce R. and Gene CurlerFrederick J. DavisJane M. and Dennis K. DouglasC. Thomas DowDonald L. and Loretta J. DrakeWilliam E. and Hazel M. DrillingDale and Cynda L. EastlickAlan A. EhrhardtShainie F. ElliottIrene FedorovichRussell G. and Janet E. FerrisBruce R. Fishburn

Kyle and Jenny FrankRobert C. FredbergLeland E. FriedrichSarah M. FuellemanRudy J. and Juile S. GaddiniSarah S. GertnerBud and Rosie GeskeBruce and Laura GibsonLinda GilmoreJulius GomolinRoger and Donna GottschalkDale R. and Barbara C. GreenFrank R. and Elizabeth H. GreenMike and Debbie GreenChris P. GuldhaugRamona S. HagenAndrew A. and Denise E. HaladaW. Andrew HarrisLois M. HeckGary B. and Jeanne M. HergertOrin A. HermundstadGary L. and Ruth A. HessBarbara HevrinBetty HillCork and Virg HiltonRodney C. and Nancy J. HiltonLeroy S. and Susan K. HoffBea HouseholderClare F. HutsonMichael S. IpGary D. JensenJerome G. KadellArlene A. KammSandy KeeserRinald J. and Teresa L. KerstenDon and Shirley KildowKeith and Marg KildowJames L. and Helen M. KindschiKristin K. KoefflerErwin F. KoenigMike and Erin KotthausDoris KoxStephen E. KraftJefferey R. Lange

Dale LangerLawrence and Jane LeachWisconsin Lions District 27-E1Wayne A. and Betsy A. LubkeKathryn K. LukasJames E. and Linda S. LykeMike and Carol MadsenNancy L. MairMarvel A. MapesJulie A. MaresJeffery Masciopinto and Sarah A. GroesslTerry V. and Kathy S. MatulleKathleen M. Mc CannBeverly A. Mc CaugheyDonna Mc CorristonPeter L. and Mary MonkmeyerRichard W. and Angie MullenFrank L. MyersNelson Lions ClubRobert W. NickellsLaverne M. O’ConnorKenneth R. and Phyllis J. PageStuart R. and Marion H. PaulVincent G. and Kathleen A. PelletierTodd W. and Tracy D. PerkinsArthur S. PolansJim and Mary QuadeCharles T. and Lucille A. RamshawBernice RiceRiver Falls Lions ClubWilma J. RohwederJames C. and Mildred J. RossChuck and Janet RoteRob and Amy RoyJames H. and Shirley RuppleTheresa A. RuschHerbert E. and Barbara C. SaundersRobert F. and Marilyn J. SchillingCarl F. Schmidt

William H. and Loretta F. SchrankMary L. ScidmoreEd and Marty ShawLonnie D. and Virginia D. ShermanWilliam E. and Miriam D. ShookChristine SilhaEric James Sobel Memorial Scholarship FundJay E. SobelDave and Nancy SonntagRobert O. and Mary K. SpahnSparta Lioness ClubAl and Chris StiegmanCindy StockmanLucille W. SunbyBarbara TankeStephen and Beverly B. ThorngateMichael TobinJim and Connie TranterCassandra A. TraxlerTwo Rivers Lions ClubMichael A. and Rhonda L. VineyDonald J. and Beth J. VruwinkAlan K. and Elise A. WalkerJ. Brian and Carol L. WatsonPhil and Lois WatsonJim and Julie WebbWest Grant Lioness ClubSheila A. WhitneyNeil F. WienkeGregory J. and Kristine L. WinnekeWoodville Lions ClubRichard J. Ziemann


FACULTY MEMBERSVOLUNTEER & AFFILIATE

Charles J. Anderson, MD

Michele A. Basso, PhD - Affiliate

Donald E. Beresky, MD

Stephen M. Boorstein, MD

Christopher R. Croasdale, MD

George E. Davis, MD

Thomas C. Dow, MD

Richard R. Dubielzig, DVM - Affiliate

Daniel R.B. Fary, MD

Judith E. FitzGerald, MD

Russell S. Gonnering, MD

Anne E. Griep, PhD - Affiliate

Kara H. Harbick, MD

Rachael S. Horn, MD

Jeffrey W. Kalenak, MD

Bradley N. Lemke, MD

Bruce M. Massaro, MD

Peter J. McCanna, MD

Kevin B. Miller, MD

Mansoor M. Movaghar, MD

Christopher J. Murphy, DVM, PhD

- Affiliate

Earl W. Nepple, MD

Bikash Pattnaik, PhD - Affiliate

Donna M. Peters, PhD - Affiliate

John G. Rose, Jr., MD

Harry Roth, MD

Kurt A. Schwiesow, MD

Michael H. Scott, MD

Morton E. Smith, MD

Robert G. Smith, MD

Stephen J. Sramek, MD

Rodney J. Sturm, MD

Michael P. Vrabec, MD

John A. Vukich, MD

Mitchell D. Wolf, MD

Tien Yin Wong, PhD

Peter N. Youssef, MD

1PRIVATE GIFTS & DONATIONS

$ 281,235

2UWMF CLINICAL CONTRIBUTIONS FOR R&D

$ 1,218,307

3RESEARCH GRANTS & AWARDS

$ 14,563,883

4 CLINICAL TRIALS $ 310,990

5 HOSPITAL SUPPORT $ 493,034

6 PRACTICE PLAN $ 23,698,867

7MEDICAL SCHOOL FACULTY SUPPORT

$ 1,172,089

8RESEARCH FEE-FOR-SERVICE AGREEMENTS

$ 7,316,736

2010 FINANCIAL HIGHLIGHTS

UNIVERSITY OF WISCONSIN DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES2828 Marshall Court, Suite 200 Madison, WI 53705

CHAIRPaul L. Kaufman, MD UW Department of Ophthalmology and Visual Sciences 2828 Marshall Court, Suite 200 Madison, WI 53705 608-263-6070 608-263-1466 fax

EDITORSarah M. Fuelleman UW Department of Ophthalmology and Visual Sciences

2828 Marshall Court, Suite 200Madison, WI 53705608-262-3953608-262-2212 [email protected]

ANNUAL REPORT EDITORIAL COMMITTEEBarbara A. Blodi, MD Yasmin S. Bradfield, MD Michelle E. Chizek, MBA Paul L. Kaufman, MD Jill Cohen Kolb, MA Robert W. Nickells, PhD Christopher C. Temme

DESIGN & PRODUCTIONGreenleaf Media

PHOTOGRAPHYAndy Manis Photo

To contribute to the UW Department of Ophthalmology and Visual Sciences, please contact:

Steve Ramig, Jr.Director of DevelopmentUniversity of Wisconsin Foundation1848 University AvenueP.O. Box 8860Madison WI [email protected]

This 2010 Annual Report was produced by the University of Wisconsin Department of Ophthalmology and Visual Sciences for referring physicians, doctors, donors, alumni and friends of the department.

To have your name removed from the Annual Report mailing list or to have your address changed, please call: Amy Zimmerman at (608) 263-1480. Or send your request to: UW Department of Ophthalmology and Visual Sciences Attn: Amy Zimmerman2828 Marshall Court, Suite 106 Madison, WI 53705

To create, integrate, transmit and apply knowledge in ophthalmology and visual sciences.

To provide high-quality comprehensive and tertiary eye care for the university health center, the Madison community, and the surrounding region in an efficient and cost-effective manner; and in select areas to serve as a resource for the nation.

To facilitate multidisciplinary research and scientific development by fostering research collaboration and mutual learning, and to play a leading role in research, teaching and collaborative studies related to the visual sciences.

To educate medical students, ophthalmologists-in-training (residents and fellows), practicing ophthalmologists, researchers in visual sciences and related disciplines, non-ophthalmology physicians, non-ophthalmology health care providers and the public.

MISSIONSTATEMENT

ANNUAL REPORT - UW Health

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