Annual Report 2007 of Kunming Institute of Botany,...

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Annual Report 2007 of Kunming Institute of Botany, Chinese Academy of Sciences 1. MESSAGE FROM THE DIRECTOR GENERAL…………………………………………………………………………………………………………………………………………………………………………………………… 2 2. ORGANIZATION STRUCTURE………………………………………………………………………………………………………………………………………………………………………………………………………………… 4 3. PROGRESS IN SCIENTIFIC RESEARCH………………………………………………………………………………………………………………………………………………………………………………………………… 5 Completion of the Southwest China Germplasm Bank of Wild Species Rated as 2007 Top Ten Pieces of News in Science and Technology in China………………… 6 Breakthrough Made on Mechanism Study of Systemic Resistance Induction of Plant Caused by New Natural Pesticide with Antivirus Activities……………………… 7 New Progress Achieved in Phylogeography Study of Taxus wallichiana complex……………………………………………………………………………………………………………………………… 8 Important Breakthrough Made in Developing New Potential Anticancer Drugs………………………………………………………………………………………………………………………………New Progress Made in Mechanism Study of Plant Responses to Low Temperature…………………………………………………………………………………………………………………………10 Important Advances Made in Study on Plant Biodiversity Origin and Evolution Mechanism in Special Habitats of Tibetan Plateau………………………………………………11 'Ninth-Five' Key Program, R&D of New Natural Drugs against Several Serious Diseases, Passed Post-Evaluation…………………………………………………………………………………………12 Stage Achievements Made in Program of Investigation and Evaluation of Biofuel Resources in Yunnan……………………………………………………………………………………………………………13 Breakthroughs Achieved in Breeding New Varieties of Wild Flowers…………………………………………………………………………………………………………………………………………………14 Marked Achievements Made in Innovation and Development of New Natural Drugs……………………………………………………………………………………………………………………………………15 Investigation on Plant Diversity in Hengduan Mountains Area, Sino-Vietnamese Boundary Areas and Indochina Peninsula Successfully Completed…………………16 Compilation of the Botany Volume of the Biology Volumes of the Great Encyclopedia of China Commenced………………………………………………………………………………………………………17 4. ACHIEVEMENTS AND AWARDS…………………………………………………………………………………………………………………………………………………………………………………………………………18 The 2007 State Supreme Scientific and Technological Award Granted to Prof. Wu Zhengyi…………………………………………………………………………………………………………18 Chemical Basic Study of Resource Drug of Higher Fungi…………………………………………………………………………………………………………………………………………………………………20 Study on Genetic Diversity and Endangerment Mechanism of Some Rare and Endangered Plants in Yunnan……………………………………………………………………………21 General Survey of Commercial Fungal Resources and Demonstration of Artificial-Promotion Propagation Techniques in Yunnan…………………………………………………22 Development of Anti-HIV/AIDS Drug, the SH Capsule………………………………………………………………………………………………………………………………………………………………23 5. SCIENTIFIC PUBLICATION AND PATENT APPLICATION………………………………………………………………………………………………………………………………………………………24 6. NEW AND ONGOING NATIONAL RESEARCH PROJECTS………………………………………………………………………………………………………………………………………………………………24 7. INTERNATIONAL AND REGIONAL COOPERATIONS………………………………………………………………………………………………………………………………………………………………………25 International Cooperation Projects Undertaken………………………………………………………………………………………………………………………………………………………………………………25 Organizations Jointly Established……………………………………………………………………………………………………………………………………………………………………………………………………26 International Conferences Sponsored or Co-sponsored by KIB………………………………………………………………………………………………………………………………………………………26 Selected Foreign Affair Activities………………………………………………………………………………………………………………………………………………………………………………………………………27 Cooperation Programs with Enterprises……………………………………………………………………………………………………………………………………………………………………………………………29 Transfer of Achievements…………………………………………………………………………………………………………………………………………………………………………………………………………………29 KIB Shareholding Enterprises……………………………………………………………………………………………………………………………………………………………………………………………………………29 8. CONSTRUCTION OF TALENTS TEAM AND SCIENTIFIC RESEARCH PLATFORMS………………………………………………………………………………………………………………………30 Breakthrough Made in Construction of High-level Talents Team……………………………………………………………………………………………………………………………………………………30 Construction of Platform for Scientific Research………………………………………………………………………………………………………………………………………………………………………………34 9. CONSTRUCTION OF INNOVATIVE CULTURE AND MANAGEMENT SYSTEM…………………………………………………………………………………………………………………………………36 Infrastructure Projects during 'Tenth-Five' and Two Major Projects Passed Acceptance Examination……………………………………………………………………………………………36 KIB Maintained its Leading Role in Public Affairs and Propagandas in CAS……………………………………………………………………………………………………………………………………36 Effectively Implementing CAS Public Affairs Management Standards………………………………………………………………………………………………………………………………37 Outstanding Individuals and Organizations Emerging Continuously in the Institutionalized and Innovative Culture Construct………………………………………………………37 Strengthen Regulation Construction and Standardized Management……………………………………………………………………………………………………………………………………………38 Institute-level ARP System Successfully Upgraded and the Second-phase Program under Preparation………………………………………………………………………………………38 Acceptation Examination of First-Stage Archive Collection to CAS Successfully Completed…………………………………………………………………………………………………………39 Appendix 1: Staff and Students ………………………………………………………………………………………………………………………………………………………………………………………………………40 Appendix 2: List of Publications…………………………………………………………………………………………………………………………………………………………………………………………………………46 Appendix 3: List of Patents Applied and Granted ……………………………………………………………………………………………………………………………………………………………………………63 Table of contents

Transcript of Annual Report 2007 of Kunming Institute of Botany,...

Page 1: Annual Report 2007 of Kunming Institute of Botany, …english.kib.cas.cn/sp/200910/P020091022594182055220.pdfAnnual Report 2007 31. MESSAGE FROM THE DIRECTOR GENERAL of Korea, Sunchon

Annual Report 2007

Annual Report 2007 of Kunming Institute of Botany, Chinese Academy of Sciences

1. MESSAGE FROM THE DIRECTOR GENERAL…………………………………………………………………………………………………………………………………………………………………………………………… 2

2. ORGANIZATION STRUCTURE………………………………………………………………………………………………………………………………………………………………………………………………………………… 4

3. PROGRESS IN SCIENTIFIC RESEARCH………………………………………………………………………………………………………………………………………………………………………………………………… 5

Completion of the Southwest China Germplasm Bank of Wild Species Rated as 2007 Top Ten Pieces of News in Science and Technology in China………………… 6

Breakthrough Made on Mechanism Study of Systemic Resistance Induction of Plant Caused by New Natural Pesticide with Antivirus Activities……………………… 7

New Progress Achieved in Phylogeography Study of Taxus wallichiana complex………………………………………………………………………………………………………………………………8

Important Breakthrough Made in Developing New Potential Anticancer Drugs………………………………………………………………………………………………………………………………9

New Progress Made in Mechanism Study of Plant Responses to Low Temperature…………………………………………………………………………………………………………………………10

Important Advances Made in Study on Plant Biodiversity Origin and Evolution Mechanism in Special Habitats of Tibetan Plateau………………………………………………11

'Ninth-Five' Key Program, R&D of New Natural Drugs against Several Serious Diseases, Passed Post-Evaluation…………………………………………………………………………………………12

Stage Achievements Made in Program of Investigation and Evaluation of Biofuel Resources in Yunnan……………………………………………………………………………………………………………13

Breakthroughs Achieved in Breeding New Varieties of Wild Flowers…………………………………………………………………………………………………………………………………………………14

Marked Achievements Made in Innovation and Development of New Natural Drugs……………………………………………………………………………………………………………………………………15

Investigation on Plant Diversity in Hengduan Mountains Area, Sino-Vietnamese Boundary Areas and Indochina Peninsula Successfully Completed…………………16

Compilation of the Botany Volume of the Biology Volumes of the Great Encyclopedia of China Commenced………………………………………………………………………………………………………17

4. ACHIEVEMENTS AND AWARDS…………………………………………………………………………………………………………………………………………………………………………………………………………18

The 2007 State Supreme Scientific and Technological Award Granted to Prof. Wu Zhengyi…………………………………………………………………………………………………………18

Chemical Basic Study of Resource Drug of Higher Fungi…………………………………………………………………………………………………………………………………………………………………20

Study on Genetic Diversity and Endangerment Mechanism of Some Rare and Endangered Plants in Yunnan……………………………………………………………………………21

General Survey of Commercial Fungal Resources and Demonstration of Artificial-Promotion Propagation Techniques in Yunnan…………………………………………………22

Development of Anti-HIV/AIDS Drug, the SH Capsule………………………………………………………………………………………………………………………………………………………………23

5. SCIENTIFIC PUBLICATION AND PATENT APPLICATION………………………………………………………………………………………………………………………………………………………24

6. NEW AND ONGOING NATIONAL RESEARCH PROJECTS………………………………………………………………………………………………………………………………………………………………24

7. INTERNATIONAL AND REGIONAL COOPERATIONS………………………………………………………………………………………………………………………………………………………………………25

International Cooperation Projects Undertaken………………………………………………………………………………………………………………………………………………………………………………25

Organizations Jointly Established……………………………………………………………………………………………………………………………………………………………………………………………………26

International Conferences Sponsored or Co-sponsored by KIB………………………………………………………………………………………………………………………………………………………26

Selected Foreign Affair Activities………………………………………………………………………………………………………………………………………………………………………………………………………27

Cooperation Programs with Enterprises……………………………………………………………………………………………………………………………………………………………………………………………29

Transfer of Achievements…………………………………………………………………………………………………………………………………………………………………………………………………………………29

KIB Shareholding Enterprises……………………………………………………………………………………………………………………………………………………………………………………………………………29

8. CONSTRUCTION OF TALENTS TEAM AND SCIENTIFIC RESEARCH PLATFORMS………………………………………………………………………………………………………………………30

Breakthrough Made in Construction of High-level Talents Team……………………………………………………………………………………………………………………………………………………30

Construction of Platform for Scientific Research………………………………………………………………………………………………………………………………………………………………………………34

9. CONSTRUCTION OF INNOVATIVE CULTURE AND MANAGEMENT SYSTEM…………………………………………………………………………………………………………………………………36

Infrastructure Projects during 'Tenth-Five' and Two Major Projects Passed Acceptance Examination……………………………………………………………………………………………36

KIB Maintained its Leading Role in Public Affairs and Propagandas in CAS……………………………………………………………………………………………………………………………………36

Effectively Implementing CAS Public Affairs Management Standards………………………………………………………………………………………………………………………………37

Outstanding Individuals and Organizations Emerging Continuously in the Institutionalized and Innovative Culture Construct………………………………………………………37

Strengthen Regulation Construction and Standardized Management……………………………………………………………………………………………………………………………………………38

Institute-level ARP System Successfully Upgraded and the Second-phase Program under Preparation………………………………………………………………………………………38

Acceptation Examination of First-Stage Archive Collection to CAS Successfully Completed…………………………………………………………………………………………………………39

Appendix 1: Staff and Students ………………………………………………………………………………………………………………………………………………………………………………………………………40

Appendix 2: List of Publications…………………………………………………………………………………………………………………………………………………………………………………………………………46

Appendix 3: List of Patents Applied and Granted ……………………………………………………………………………………………………………………………………………………………………………63

Table of contents

Page 2: Annual Report 2007 of Kunming Institute of Botany, …english.kib.cas.cn/sp/200910/P020091022594182055220.pdfAnnual Report 2007 31. MESSAGE FROM THE DIRECTOR GENERAL of Korea, Sunchon

2 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

In 2007, the second year of the third-phase of Knowledge Innovation Program, Kunming Institute of Botany (KIB) has achieved great progress in terms of research projects, talents construction, platforms’ establishment for scientific research, international cooperation and industrial ization. Besides signif icant academic achievements, KIB has further consolidated its institutionalized and innovative culture construction in the past year. As for national, Chinese Academy of Sciences (CAS) and provincial projects undertaken, KIB has obtained a number of research funds including one special project for basic research of Ministry of Science and Technology of China (S&T), 22 projects of National Natural Science Foundation, 14 Yunnan Provincial S&T Foundation projects and two Yunnan Talents projects. In addition, KIB participated in two 973 Programs and 10 new international cooperation projects have been signed up. In terms of talents construction, Dr. Tan Ninghua received a grant from the National Science Fund for Distinguished Young Scholars, making herself the seventh winner from KIB, and five high-level faculties were recruited through the Talent Recruiting Plan. Talents position-classification management has been initially completed. KIB presently owns 272 graduate students, two doctoral students won 2007 CAS President’s Award for Excellence and six graduate students won 2007 CAS Honor Awards. Prof. Wu Zhengyi, academician of CAS, was granted the State Supreme Scientific and Technological Award in 2007. KIB received two first-class and one second-class natural science prizes of Yunnan Scientific and Technological Award, one second-class prize of Yunnan Scientific and Technological Progress Award. With articles embodied by SCI index numbered 202, of which, 34 articles were published

1. MESSAGE FROM THE DIRECTOR GENERAL

on journals of TOP 15% of the JCR related fields, KIB has made evident progresses in scientific publication, both in terms of quantity and in quality of the papers. In 2007, KIB successfully published articles on some world preeminent journals such as Proceedings of the National Academy of Sciences (PNAS), Molecular Ecology and Cell Death and Differentiation. Two papers of KIB were included into 'One-hundred Most Influential International Scientific Papers in China' sponsored by Ministry of S&T, namely, 'Natural Terphenyls: Developments since 1877' published in Chemical Reviews by Prof. Liu Jikai in 2006 and 'Plant Cyclopeptides' published in the same journal and the same year by Prof. Tan Ninghua and Prof. Zhou Jun, academician of CAS. Construction work of the state key scientific facilitation project 'The Southwest China Germplasm Bank of Wild Species' has been completed in April 2007. Collecting and screening germplasm resources have also made steady progress. The completion of the first germplasm bank of wild species in China was rated as one of the 2007 Top Ten Pieces of News in Science and Technology in China both by academicians from CAS and Chinese Academy of Engineering (CAE). In addition, the website of Botanical Garden of Kunming has been made available and the plants of various sections were listed in the column 'Plant Database' of the webpage. Supported by Great Encyclopedia of China Office and Yunnan Education Publishing House, the editing work of 'Botany Volume of the Biology Volumes of the Great Encyclopedia of China' formally commenced at KIB. The KIB-National Science Library Domain Information Service Station formally launched in 2007. Yunnan Green-Land Biological Technology Co., Ltd., a KIB shareholding enterprise, was successfully listed in the stock market in 2007, setting an excellent paradigm for transfer of scientific research achievements at KIB. It also provides valuable experience and reference for KIB in facilitating industrialization. In the past year, KIB has signed cooperation agreements and memoranda of understanding for scientific research with many organizations including Korean Industry Promotion Agency, National Institute of Biological Resources

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3Annual Report 2007

1. MESSAGE FROM THE DIRECTOR GENERAL

of Korea, Sunchon National University, Singapore Temasek Life Sciences Laboratory and the Chinese University of Hong Kong. The cooperation projects between KIB and Mary Kay, NOVATIS are being carried out smoothly. Moreover, KIB has initiated and organized a series of international symposia, workshops and training courses that accomplished beneficial effects with universal praises from Chinese and international participating scientists. International symposia and workshops sponsored by KIB included Inception Workshop on Medicinal and Aromatic Plants Traditional Knowledge Bank in Southwest China, Dialogue Session of Medicinal Plants Conservation in China, India, UK and Himalayan Areas and the 5th International Workshop of Edible Mycorrhizal Mushroom, and international training courses KIB initiated included 'Training Course of Edinburgh, Kunming and Lijiang Horticulture' and 'Workshop on Population Genetics' and 'Workshop on the Vienna edition of International Code of Botanical Nomenclature', etc. In 2007, scientists from many countries and academic organizations including American National Science Foundation (NSF), Yale University, Wisconsin University, Royal Botanical Gardens Kew, Royal Botanical Garden Edinburgh, Edinburgh University, University of Bonn and Institute of Ecology and Biological Resources of Vietnam Academy of Sciences visited KIB and conducted wide discussions and exchanges with KIB scientists, greatly enhancing KIB’s international cooperation with other research institutes. KIB has also made advances in institutionalized and innovative culture construction. Through strenuous efforts, KIB has made steady progress in implementing the CAS public affairs management standards and reached two CAS first-class standards in terms of security management and information propagandas, two CAS second-class standards in archive processing and filing management, respectively. KIB was rated as an 'Outstanding Institution' in propagandizing information about implementation of CAS public affairs management standards, and in assets checking. The civil construction projects

proceeded steadily with three projects passing the professional acceptance inspection for completion sponsored by CAS. Five construction projects including the reconstruction project of the Herbarium (KUN) passed the program acceptance inspection sponsored by CAS. Project of 'Ornamental Foliage and Fruit Plant Garden' of the Botanical Garden has as well passed the inspection and the project of wastewater treatment plant is under construction with substantial progress. Depending on full devotion and arduous endeavors, KIB has made many significant achievements, and KIB will celebrate its 70th anniversary in 2008. In the New Year, we will continue our unrelenting efforts and courage to make even more distinguished achievements. Under the direct leadership of Communist Party of China (CPC) CAS Committee, together with unrelenting endeavors of the KIB entire staff and graduate students, we would certainly achieve more significant and faster developments in 2008, dedicating to the 70th anniversary of KIB.

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4 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

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State Key Laboratory of Phytochemistry and Plant Resources in West China

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Horticulture Center of Botanic Garden

Laboratory of Ethnobotany

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Institute of Tibetan Plateau Research at Kunming, CAS

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Center for Mountain Ecosystem Studies

Botanical Society of Yunnan

Logistics Center

KIB-Mary Kay Joint Lab

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Annual Report 2007

3. PROGRESS IN SCIENTIFIC RESEARCH

With the CAS Key Laboratory of Biodiversity and Biogeography, State Key Laboratory of Phytochemistry and Plant Resources in West China, the Southwest China Germplasm Bank of Wild Species and the Botanical Garden as the basic research units and scientific research platform, KIB, in 2007, consecutively dedicated its efforts in aiming the scientific frontiers of international botanical science and biodiversity conservation researches according to China’s strategic needs, especially to the ambitious West Exploration Program, KIB devoted to underscoring originally scientific innovation, strengthening strategic high-tech innovations and made great progress in biogeography, phytochemistry, plant genomics, conservation biology, developing of new drugs and utilization of plant resources. Relying on these achievements, KIB has made important contributions to sustainable utilization and conservation of biodiversity, regional economic development and social progress.

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6 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

Completion of the Southwest China Germplasm Bank of Wild Species Rated as 2007 Top Ten Pieces of News in Science and Technology in China

With total investment valuing RMB 148 million yuan, the Southwest China Germplasm Bank of Wild Species is a state-key science facilitation project. According to the blueprint, the germplasm bank consists of seed bank, DNA bank, plant germplasm in-vitro, microorganism bank, animal germplasm, information center and research laboratory, etc. Centering on conservation of germplasm of wild species in Yunnan and in adjacent areas (including Qinghai-Tibetan Plateau), the main species gathered are plant germplasm resources, containing some animal and microorganism resources. The construction of the bank would provide technological supports and basis of decision-making for conservation, studies, development and effective utilization of germplasm resources of wild species in China. In five years, 66500 accessions of 6450 species, will be collected and preserved at the germplasm bank, and the number will climb to 190000 accessions of 19000 species in fifteen years. The ultimate goal of the bank is to be a world-class, integrative germplasm bank and scientific facility for conservation of wild species, ensuring the security of China’s strategic biological resources. The germplasm bank will supply materials and information for development of industry and researches of life sciences so as to facilitate the sustainable development of biotechnological industry and social economic development in China and to lay a material foundation for fulfilling the goal of effective biodiversity conservation and strategy of sustainable development. The principal part of the germplasm bank project passed the acceptance inspection in 2007. Relying on support of the Scientific Basic Platform Construction Program, KIB successfully initiated the program of standardized screening of 13708 accessions of 3000 species, which involved with 206 persons of 15 institutions from varied areas of Southwest China, Central China, Northwest China, North China, South China and East China. In addition, 15028 accessions

were gathered with digital expression and number for information sharing exceeded 10000 and 1764 accessions of 710 species can be shared in form of actual specimens, through e-platform and the networking system of the Southwest China Germplasm Bank of Wild Species. In gathering, screening and conservation of the germplasm resources, special attention was attached to rare and endangered plant species, such as Paraisometrum, Nyssa yunnanensis and Taxus. Based on the previous work, the ambitious goal of gathering will be achieved, which would make important contributions to implementing international conventions, effective conservation of biodiversity and to sustainable development. Completion of the South- Completion of the South-west China Germplasm Bank of Wild Species was voted as 2007 Top Ten Pieces of News in Science and Technol-ogy in China voted by an evaluation group consisting of 574 academicians from CAS and CAE.

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Breakthrough Made on Mechanism Study of Systemic Resistance Induction of Plant Caused by New Natural

Pesticide with Antivirus Activities

Plants have evolved multiple mechanisms to selectively suppress pathogens by production of secondary metabolites. Therefore, direct selections for antiviral compounds from plants can be used to identify new agents with potent antiviral activity but not toxic to hosts. In collaboration with CAS Institute of Microbiology, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC) and Institute of Biotechnology, Yunnan Academy of Agricultural Sciences (YAAS), the research group led by Prof. Hao Xiaojiang, for the first time, found that a class of compounds, seco-pregnane steroid glaucogenin C and its monosugar-glycosides are effective and selective inhibitors to alphavirus-like positive-strand RNA viruses including plant-infecting tobacco mosaic virus (TMV) and animal-infecting Sindbis virus (SINV), eastern equine encephalitis virus (EEEV), and Getah virus (GETV), but not to other RNA or DNA viruses, yet they were not toxic to host cells. In vivo administration of the compounds protected BALB/c mice from lethal SINV infection without adverse effects on mice. Using TMV and SINV

as models, studies on the action mechanism revealed that the compounds predominantly suppress the expression of viral subgenomic RNA(s) without affecting the accumulation of viral genomic RNA. Their work suggested that the viral subgenomic RNA could be a new target for the discovery of antiviral drugs, and that seco-pregnane steroid and its glycosides found in the two kinds of medicinal herbs have the potential for further development as antiviral agents against alphavirus-like positive-strand RNA viruses. This study was published in the journal of PNAS (PNAS, 2007, 104(19): 8083-8088).

Page 8: Annual Report 2007 of Kunming Institute of Botany, …english.kib.cas.cn/sp/200910/P020091022594182055220.pdfAnnual Report 2007 31. MESSAGE FROM THE DIRECTOR GENERAL of Korea, Sunchon

8 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

New Progress Achieved in Phylogeography Study of Taxus wallichiana Complex

China is one of the distribution centers of Taxus wallichiana plants complex and the State Council included T. wallichiana into the list of state key wild plant species (volume A) in 1999. However, species number of T. wallichiana complex distributed in China remains a problem with major viewpoint divergence in the status of Chinese yew, South China yew and Himalayan yew distributed ranging from mountainous region of Southeast China to Himalayan areas. Since 2004, the research group led by Prof. Li Dezhu, in cooperation with Royal Botanical Garden Edinburgh, has spent over three years collecting a total of 1235 individuals from 50 populations from 14 provinces of China including Yunnan, Sichuan, Shannxi, Guizhou, Guangxi, Guangdong, Hunan, Hubei, Henan, Anhui, Zhejiang, Jiangxi, Fujian and Taiwan, and North Vietnam for analyses. The study, jointly supported by CAS and the Royal Society of London, distinguished 19 different chloroplast haplotypes of the compex using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for chloroplast DNA variation. The researchers found a very high level of population differentiation and a strong phylogeographic pattern. Haplotype differentiation was most marked along the boundary between the Sino-Himalayan and Sino-Japanese Forest floristic subkingdoms. The researchers concluded that several localized refugees existed during the last glaciation from which the present-day distribution of Himalayan yew may be derived. This study is published in the journal of Molecular Ecology (2007, 16(22): 4684-4698).

Page 9: Annual Report 2007 of Kunming Institute of Botany, …english.kib.cas.cn/sp/200910/P020091022594182055220.pdfAnnual Report 2007 31. MESSAGE FROM THE DIRECTOR GENERAL of Korea, Sunchon

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Important Breakthrough Made in Developing New Potential Anticancer Drugs

In collaboration with State Key Laboratory of Medical Genomics in Shanghai Jiao Tong University, Shanghai Institutes for Biological Sciences in CAS, and Rui Jin Hospital, Prof. Sun Handong, academician of CAS, observed significant apoptosis of t (8; 21) chromosome translocation through NF-κB and MAPK pathways, concomitant with caspase-3 activation. AML1-ETO oncoprotein was degraded in parallel to caspase-3 activation. The study was published in the journal of Cell Death and Differentiation (2007, 14(2), 306-317). Through profound studies on the medicinal mechanism of eriocalyxin B (EriB), which was tested on AML-M2b leukemia cells, the researchers concluded that Kasumi-1 and AML-M2b murine leukemia cells were most sensitive to EriB (even at μM level) with significant apoptosis. EriB-mediated apoptosis was associated with NF-κB inactivation by preventing NF-κB nuclear translocation and EriB was effective on

primary t(8;21) leukemia blasts and caused AML1-ETO degradation. The high-degree selectivity and low-concentration medical effect suggested that EriB might be a low-toxicity, high-performance molecular-targeted agent, with great potential to candidate drug for targeting therapy of AML-M2b type leukemia.

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10 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

New Progress Made in Mechanism Study of Plant Responses to Low Temperature

Low-temperature stress is a major environmental factor effecting the growth, geographic distribution and yields of plants, and damages resulted from cold and freezing stress usually occurred in membrane. Changes in membrane lipid composition play important roles in plant adaptation and survival after freezing. Plants’ response to cold and freezing involves three distinct phases: cold acclimation, freezing, and post-freezing recovery. In collaboration with American scientists, the research group led by Prof. Li Weiqi carried out the study on how the 120 lipid species change during freezing and post-freezing recovery of Arabidopsis thaliana freezing tolerance, and on the effect of two phospholipase D (PLD), PLDα1 and PLDδ during these phases, using lipidomics based on ESI-MS/MS. The results showed that different type of lipids and lipids of different cellular orientation react differently during freezing and post-freezing recovery, and suppression of PLDα1 and PLDδ resulted to different effects on

phospholipid hydrolysis in freezing and post-freezing recovery. Thus the changes of membrane lipids in two ecotypes and four genotypes during three phases of Arabidopsis thaliana freezing tolerance were analyzed and determined in details, laying an important formation for further elucidating the mechanism of plants responses to low temperature. The results were published online on The Journal of Biological Chemistry in Dec. 2007, and the paper was rated as one of the outstanding scientific achievements of China Mainland and Hong Kong by the magazine Nature China.

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11Annual Report 2007

Important Advances Made in Study on Plant Biodiversity Origin and Evolution Mechanism in Special Habitats of Tibetan Plateau

Main contents of the project presided by the research group of Prof. Sun Hang contain three aspects, namely, characteristics of Tibetan Plateau, evolution model of representative populations, biodiversity mechanism and evolution speed, species adaptation mechanism under extreme environmental conditions and features of reproductive biology, and chromosome ploidy evolution under extreme environmental conditions of Tibetan Plateau. The results demonstrated that plant diversity of this area involves background of flora of Tethys, and that many plants with shorter evolution history result from rapid uplift process of the plateau. According to cytological studies, flora of this area owns great potential for further evolution, whether in terms of representative populations under extreme conditions, or of general level. And natural hybridization probably functions as one of the drives for evolution. On the other hand, dispersal of Arctic-

Tertiary flora also profoundly influenced the flora of this area. Evidence obtained as well suggested that Bering dispersal route played a critical role in forming the flora of this area through molecular biogeography analyses. Both vicariance and dispersal are important causes for the flora distribution. Under the extreme environmental conditions, plants also developed many special adaptation structures, which have multiple ecological functions, ensuring their survival and evolution under tough habitats. A total of 53 articles have been published for this project, among which 38 are published in SCI-embodied journals including top 15-30% journals of the same field such as Molecular Ecology, American Journal of Botany, Moleculer Phylogenetics and Evolution, Annals of Botany, etc.

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12 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

'Ninth-Five' Key Program, R&D of New Natural Drugs against Several Serious Diseases, Passed Post-Evaluation

In Sep. 2007, a post-evaluation was carried out on the CAS 'ninth-five' key and special-support program, R&D of New Natural Drugs against Several Serious Diseases, co-chaired by Prof. Hao Xiaojiang from KIB, Prof. Ding Jian from Shanghai Institute of Materia Medica, CAS and Prof. Li Boliang from Shanghai Institute of Biochemistry, CAS. The post-evaluation conducted by CAS Program Evaluation and Supervision Center by a group of leading scholars and experts including CAS academicians, Prof. Chen Kaixian and Prof. Sun Handong, and Profs. Ma Hongjian, Kong Lingyi, Du Guanhua, Lin Wenhan, senior chemist Mr. Yang Lahu and Prof. Zhang Guolin, etc., achieved satisfying results. After termiation of the program, important progress has been made on basis of previous research results and a series of achievements been fulfilled: five new drugs obtained drug approval numbers and another five new drugs obtained approval for clinical trials,

one new drug completed clinical trial (phase III) and the application for new drug certificate is being conducted. Three n e w d r u g s o w n i n g independent intellectual property rights (IPR), on wh i ch p rec l i n i ca l researching work have already been finished, obtained approvals for clinical trials successively.

As for biotechnological drugs, two certificates for new drugs, one approval for clinical trials of new drugs and one new drug certificate for clinical laboratory kit have been obtained. To date, industrialization of several researching results has already accomplished enormous economic and social benefits.

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Stage Achievements Made in Program of Investigation and Evaluation of Biofuel Resources in Yunnan

As one of the most ancient energy source for human and an important renewable energy resource, biofuel resource is very important, and accelerating the development and utilization of biofuel resource has a great significance. Supported by Yunnan Provincial Development and Reform Commission, a research group consisting of scientists of multiple disciplines including plant taxonomy, plant introduction and cultivation, molecular biology, plant physiology, phytochemistry and ethnobotany, has investigated and gathered basic informative materials concerning biological, ecological and economic characteristics of Jatropha curcas in a short period of time. Through additional field surveys and studies on chemical components of the plant oils, the research group has thoroughly and systematically analyzed and summarized the geographic distribution of Jatropha curcas in whole Yunnan, parts of Sichuan and Guangxi provinces, with information of the resource quantity, ecological and biological features, optimum habitats for, targeted biomass per unit area and chemical property of plant oil, etc. Meanwhile, the research group has carried out complete analyses and evaluation on climatically and geographically optimum regions for plantation of Jatropha curcas, principles for industrial development planning and challenges for Yunnan to

develop the industry of Jatropha curcas were outlined, which can be extremely valuable data and reference for the industrial development planning of Jatropha curcas in Yunnan. The program has already evaluated the acceptance inspection by a group of experts sponsored by Yunnan Provincial Development and Reform Commission.

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Breakthroughs Achieved in Breeding New Varieties of Wild Flowers

The research group led by Prof. Zhang Changqin has been engaging in breeding of new varieties of alpine wild flowers, especially of introduction and domestication of rhododendron for many years. After 20 years’ efforts and on basis of the 126 domesticated varieties of Yunnan wild rhododendron and hybridized breeding, the research group has started bud and sprout breeding recently and successfully developed six rhododendron varieties, i.e. Rhododendron. 'Hongyun', R. 'Xuemeiren', R. 'Jinzhizhu', R. 'Ziyan', R. 'Jiaoyan' and R. 'Xilinmen'. All the six varieties passed substantial examination by experts of the same field organized by the New Variety Office of State Forestry Administration. These six new cultivars are innovative, special, constant and stable with scientific names, which accords to the conditions described by International Code of Nomenclature for Cultivated Plants and new horticultural cultivars. Technological propagation studies on cutting and sowing of the identified rhododendron cultivars have been already carried out and initial results been achieved. These new cultivars are the first new rhododendron varieties evaluated by

the State Forestry Administration. At the same time, the research group led by Prof. Gong Xun has developed a new cultivar of Michelia figo, M. figo 'Wanchun' which passed the evaluation by experts sponsored by the New Variety Office of State Forestry Administration. Through five-year observations and studies on innovation, specificity, consistency and stability, the research group finished studies on cutting propagation, tissue culture and cultivation technology. With distinguished horticultural characters and strong adaptation ability, the M. figo 'Wanchun' is very suitable for garden greening. It is the first M. figo cultivar and evergreen variety of Magnoliaceae that apply for state-level protection for new plant varieties.

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Marked Achievements Made in Innovation and Development of New Natural Drugs

Natural drug has been an indispensable part of world pharmacology. Discovering various physiological activities and drug lead compounds from natural drugs and ethno-pharmacology plays a critical role in R&D of new drug with independent intellectual property right. Development of new natural drugs on basis of elucidating activity components of traditional drugs is the current trend. KIB has already constructed a talents’ team for R&D of new drugs with independent intellectual property rights, which consists of experts mainly from the State Key Laboratory of Phytochemistry and Plant Resources in West China, and from other departments as well. New drugs under clinical trials: clinical trials of anti-HIV/AIDS drug, SH capsule have been completed in Thailand (transferred); clinical trials (phase III) of the new drug against cardio-cerebral vascular diseases, Denzhanxixin injection and clinical trials (phase I) of the new drug against presenile dementia, phenchlobenpyrrone have been completed, respectively. Approvals for clinical trials of cepharanthine hydrochloride and cepharanthine hydrochloride injection have been obtained. New drugs with completion of preclinical studies include anti-HIV/

AIDS drug, Qishile capsule, Emei-glucoside capsule against gynecology hemostasis, hypoglycemic drug, CA-1 and cough-reliving drug, dengtaiye. Drugs under clinical trials include: anti-HIV/AIDS candidate drug, schizandrin and Flazin, anti-leukaemia candidate drug, diterpenoids, anti-depression candidate drug, CXZ-123, lipase inhibitor, vibralactone, antitumor candidate drugs, GC-51, actaea asiatica and sesquiterpene from Inula britannica, etc.

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Investigation on Plant Diversity in Hengduan Mountains Area, Sino-Vietnamese Boundary Areas and Indochina Peninsula Successfully Completed

The fourth Sino-American joint investigation on plant diversity in Hengduan Mountains Area co-sponsored by KIB and Harvard University lasted one and a half months and length of the journal exceeded five thousand kilometers. This investigation has finished the basic material-gathering in weakened and key areas for plant diversity in Northwest Sichuan. The plant populations investigated covered seed plants, fern flora, bryophytes and higher fungi and key places surveyed were mainly dry-warm and dry-hot valleys, screes, alpine meadow, and vegetation types of primary forests and secondary forests. The obtaining of basic information of large-quantity plants from weakened and key places in Hengduan Mountains Areas, such as alpine-cold quillwort, Ranunculaceae and Kingdoniaceae, laid an important foundation for biogeography studies on important populations and for exploring the origin and evolution of representative populations of this area. This study will as well provide beneficial theoretic and technological suggestions and references for protection of endangered plants and construction of natural reserves. Supported by the National Geographic Society of USA, KIB investigation team successfully completed the first investigation research on vascular plants in Sino-Vietnamese boundary areas of Yunnan. The investigation team has taken a total of over 6000 field photos and gathered more than 600 specimens, and

collected samples of some epiphytic plants and populations of Caryota urens. Sino-Vietnamese boundary area of Yunnan is one of the most crucial regions linking China and flora of Indochina Peninsula. It’s not only the important part of the center of ancient, special plants in Yunnan, Guizhou and Guangxi of China, but also is the core part of Southeast Yunnan Center, which is one of the two biodiversity centers in Yunnan. The investigation results will be published in the magazine National Geographic. Owing to support of National Geographic Society of USA, KIB scientists carried out the program of the second-phase investigation on fern in Indochina Peninsula. With extremely friendly reception and support of Laos Traditional Medicine Research Center (TMRC), the scientists visited central areas of Laos, such as Ganmeng Province, Bolikansai Province and Wanrong District of Vientiane. This field investigation gathered several hundred specimens, some spores and materials for molecular studies. For the fist time, a systematic survey and study on fern in Laos was carried out.

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Editing Work of Botany Volume of the Biology Volumes of the Great Encyclopedia of China Commenced

Due to support and concerns from Great Encyclopedia of China Office and Yunnan Education Publishing House, inception meeting for the editing work of 'Botany Volume of Biology Volumes of the Great Encyclopedia of China' was held at KIB from June 26-27, 2007. KIB and CAS Institute of Botany are the principal editing institutions for the Botany Volume, with Prof. Li Dezhu, director general of KIB and Prof. Ma Keping, director general of CAS Institute of Botany as the editors-in-chief, Prof. Peng Hua and Dr. Wang Jinxiu as the vice editors-in-chief. The editing committee totally consists of 18 experts. Relying on recommendation and encouragements by Prof. Wu Zhengyi, academician of CAS and editor-in-chief of Biology Volumes of the Great Encyclopedia of China, an editing team consisting of senior experienced experts and young scientists has already been constructed, laying a firm intellectual foundation for editing of the encyclopedia. It’s a traditional convention to edit encyclopedia in prosperous age throughout the history. In the important stage of constructing a moderately prosperous and harmonious society, the central government of China determined to compile the Great Encyclopedia, which is not only requirement for heritage and developing excellent Chinese culture, but also a must for construction of socialist culture with

Chinese characteristics a n d n e w m a r k e d contr ibut ion to the world’s c iv i l izat ion.Tremendous amount cultural classic books are the main carries of Chinese thousands’ y e a r s o f s p l e n d i d

culture, symbolizing China’s outstanding contributions to the human civilization. Using scientific classification methods, a complete, scientific and systematic compilation and filing of cultural masterpieces from pre-Qin to 1911 revolution will be carried out firstly so as to provide accurate, detailed materials for the academia and related departments. The Great Encyclopedia of China now includes books on natural sciences for the first time, with evident features of the times. The completion of the encyclopedia will benefit the entire Chinese people. The editing of the Plant Volume of the encyclopedia is general collection of books on botanical knowledge before 1911, which will reflect the overall comprehending to botany of entire Chinese people, and will record the materials of plant diversity and its changes ever occurred in China throughout the Chinese history. Such editing work of the encyclopedia will link different generations and syncretize knowledge of ancient and modern times with great significance.

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18 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

4. ACHIEVEMENTS AND AWARDS

The 2007 State Supreme Scientific and Technological Award Granted to Prof. Wu Zhengyi

Prof. Wu Zhengyi, a CAS academician and Emeritus Director of KIB was granted the State Supreme Scientific and Technological Award in 2007.

Born in Jun. 1916 and graduated from Tsinghua University Department of Biology in 1937, Prof. Wu became a member of China Democratic Alliance in 1945 and a CPC member in 1946. In Jun. 1949, he became vice head of the Higher Education Division of Beijing Municipal Military Control Commission. Later on, he entered CAS in December of the same year, where he went on to fill a string of prestigious positions, including secretary of the CPC Branch Committee of CAS, Deputy Director of CAS Institute of Plant Taxonomy (1950), Member of Biology Division of CAS (1955), Director of KIB (1958-1983), Member of the Presidium of Academic Divisions of CAS (1981), and Director Emeritus and Professor of KIB, his current positions. Prof. Wu, who has been engaged in botanical research and education for 70 years, is a world-famous botanist and an authority in the fields of

plant taxonomy, systematic botany, floristic geography, and conservation and utilization of plant resources in China and elsewhere in the world. Prof. Wu has been actively involved in one of the largest floristic projects in the world, Flora Reipublicae Popularis Sinicae (FRPS), which is the most comprehensive work of its kind that characterizes plant species and their distribution in China, and also is a marked achievement of three generations of botanists. He plays a crucial role in the project and has made unparalleled contributions to the compilation of FRPS. Prof. Wu participated in and directed several investigation projects of plant resources in China. In all, he authored or co-authored 1766 taxa (species or genera) of plants, the highest among all Chinese botanists.

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It is his critical contribution that terminated the history that flora growing in China was largely named by foreign botanists. He worked on all vascular plants in China and managed to identify their total number. He successfully worked out major patterns of distribution of seed plants in China and their composition, roles, positions, relationships and evolutionary processes. He proposed the new theory of 'Eight-Class System of Classification of the Angiosperms'. In terms of floristic geography, Prof. Wu greatly put forward the floristic geography theory to explain the origin and evolution of Chinese plants, forming a string of innovative researching thoughts and methodologies on floristic geography. He pointed out the phylogenic relations between Chinese flora and that of tropical area, and revealed the distributional patterns of Chinese flora and their role in a global context. He modified the system of floristic regions of the world, making significant contributions to studies on biodiversity. Wu’s contributions also lie in the effective use of plant resources and conservation of plant diversity in China. At the beginning of the founding of the People’s Republic of China, he was in charge of a project of introducing rubber trees in subtropical areas, and with other colleagues, he resolved a series of technological problems concerning cultivation of rubber trees, tremendously lessening the imperative problem of lacking strategic resources of China. His research greatly facilitated the exploration, development & utilization and introduction & domestication of plant resources in China. He was the first to call for the foundations of national natural reserves and a

germplasm bank of wild species, which received concerns from the central government and top leaders. Now numerous natural reserves and the germplasm bank of wild species have been constructed. Prof. Wu’s work plays a critical role in conservation of biodiversity and sustainable utilization of resources in China. Wu Zhengyi has published more than 140 papers, including 75 SCI-embodied articles, and edited (or co-edited) over 20 monographs, for instance, Flora Reipublicae Popularis Sinicae, Flora of China, Flora Xizangica, Flora Yunnannica. In recognition Wu’s great contributions, he has been awarded many scientific prizes including the International Cosmos Prize, six National Scientific Awards, one international award and the honor of Outstanding Worker of National Science Congress. Preciseness personified, Prof. Wu has cultivated a great many excellent scholars and scientists who have already become senior scientists and project leading experts of varied research fields. Wu now still engages in research work and became the editor-in-chief of the Biology Volumes of the Great Encyclopedia of China. He has even published important papers in recent years. For his deep understanding on flora, Prof. Wu is one of the most famous botanists in the world. He has made basic, innovative and forecasting contributions to botany and protection and use of plant resources in China. Obtaining of the State Supreme Scientific and Technological Award is not only a recognition and praise for his distinguished contributions, but also a proud for all plant scientists in China.

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Chemical Basic Study of Resource Drug of Higher Fungi

Type and Class of Award:Science and Technology Progress of Yunnan Natural Science, First-class Award Completion Unit:Kunming Institute of Botany, Chinese Academy of SciencesMain Contributors:Liu Jikai, Wang Fei, Dong Zejun, Qin Xiangdong, Liu Dongze, Tang JianguoMain Contents and Impacts:This program carried out systematic studies on chemical components and biological activity of some higher fungi in Yunnan. Studies on chemical components of over 50 kinds of wild higher fungi and screening of medicinal activity of higher-fungi fruit bodies and fermentation broth extract have been completed. Through this study, over 300 kinds of compounds have been identified, 100 of which are new compounds (three compounds with new structure framework). A great many natural components with innovative structures and biological activity have been obtained. The founding of concentricolide, a compound that can inhibit HIV-1 virus, cell-binding and cell fusion, vibralactone, natural activity substance strongly inhibit the activity of pancreatic lipase and grifolin, a compound used for tumor signal molecular conductive and for induction of cell apoptosis is of great innovation. One monograph named Higher Fungi Chemistry has been published, which will greatly facilitate the studies on higher fungi. A total of six patents have been obtained and 53 articles, including 46 SCI-embodied articles (213 times for citation) been published. Among the articles two (impact factor in 2005 was 20.869) were published on the world famous journal Chemical Reviews sponsored by America Chemical Society.Three compounds were included into the list of 'research hotspot' by the preeminent journal Natural Product Reports , suggesting the academic influences of the research group in the field of higher fungi chemistry.

With evident characteristic and creativity, this achievement made important contributions to rational use and development of higher fungi resources in China, and especially in Yunnan. The experts from the evaluation team unanimously rated this achievement to be internationally 'advanced-level' among researches of the same field and some results to be internationally 'leading-level'.

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Study on Genetic Diversity and Endangerment Mechanism of Some Rare and Endangered Plants in Yunnan

Type and Class of Award:

Science and Technology Progress of Yunnan Natural Science First-class Award

Completion Unit:Kunming Institute of Botany, Chinese Academy of Sciences

Main Contributors:Gong Xun, Pan Yuezhi, Xiao Longqian, Luan Shanshan, Tian Bo, Yang Shuda, Yang Zhiyun, Yang Yang

Main Contents and Impacts:This program carried out complete and profound surveys on rare and endangered plants in Yunnan and Southwest China, and elucidated the patterns and status of their geographical distribution, especially the endangerment of some populations, for instance, the Extinction in the Wild (EW) of Poncirus polyandra and almost EW of Cycas multipinna and C. longipetiolula. Through this program, more than 180 species of rare and endangered plants and some rare germplasm genes have been conserved. The growth mechanism and adaptation capacity of preserved species in the ex situ reserves have been identified. In addition, population rebuilding experiments on species including Manglietiastrum sinicum, Parkmeria yunnanensis, Manglietia aromatica, Liriodendron chinense, Cycas tanqingii, Manglietia insignis from the experimental regions of Xichou Xiaoqiaogou Reserve and Jinping Fenshuiling Reserve were conducted to increase the population number. Moreover, studies on reproductive process including forming of megaspore and microspore, male and female gametophytes, pollination, fertilization were carried out to explore the endangerment mechanism from the perspective of reproductive biology, based on which relative protection countermeasures will be proposed.

Using molecular biology methods, the genetic diversity and structures of national protection plants, including Cycas guizhouensis, Cycas balansae complex, Paeonia delavayi, Citrus hongheensis and Nouelia insignis were studied and relations between genetic models and species endangerment analyzed. For the first time, cytological studies on some Chinese unique plants and plants with higher utilization value, such as Paeonia delavayi, Cycas, Calycopteris, Anemoclema glauciifolium, Heteroplexis microcephala, Psammosilene tunicoides were undertaken and relative basic materials have been accumulated. A total of 24 articles concerning the research results have been published including eight SCI-embodied articles with total IF value amounting to 15.502, on preeminent journals, such as Annals of Botany, Australian Journal of Botany and Biodiversity Science, etc. In summary, this achievement is multiple-level, systematic and profound research on rare and endangered plants in Yunnan, accumulating basic information materials of these plants. This program as well discussed the endangerment mechanism of these rare and endangered plants in terms of reproductive biology and genetic diversity, and proposed effective measures for plant protection. The research group has successfully published three articles in the journal Annals of Botany , and the research results of this program reached internationally leading level with important theoretic significance and great potential in plant conservation.

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Approximate Percentage of Trade of Each Kind

of Wild Fungi

General Survey of Commercial Fungal Resources and Demonstration of Artificial-Promotion Propagation Techniques in Yunnan

Type and Class of Award:Science and Technology Progress of Yunnan Natural Science Second-class Award Completion Unit:Kunming Institute of Botany, Chinese Academy of Sciences, Lancang Bureau of Science and Technology, Puer, Yunnan Main Contributors:Liu Peigui, Wang Xianghua, Yu Fuqiang, Zheng Huanti, Chen Juan, Chen JiyueMain Contents and Impacts:Wild edible mushroom is the first-class, large-volume, non-timber product for exportation in Yunnan, which plays an increasingly important role in ecological environment construction and social and economic development. This program engaged in complete and systematic studies on the special industry in Yunnan, wild commercial mushroom industry. On basis of surveys on large number of agricultural product trading markets and wild investigation, the program carried out modifications for the previous classification of commercial fungi and provided additional descriptions in details. A number of new species and specimens have been renamed and recorded with correct names and classification. A total of 22 articles and one practical pictorial handbook have been published through this program. The gathering of commercial fungi species, which laid an important foundation, and screening and identification of key populations, which provided important theoretic basis for protection and utilization of them, are both revolutionary work with great significance. In addition, the public scientific-knowledge promotion campaigns and training courses on technology dissemination of this program also won wide praises. Great progresses have been achieved in artificial synthesis of three important mycorrhizal fungi and mycorrhiza of population plant species and human-power cultivation experiment technology of Lactarius volemus, generating tremendous influences in local area and inaugurating a new way for facilitating economic development and fulfillment of sustainable utilization of wild edible fungi under forestry. Such technology with originality is widely cited by similar scientists, causing general concerns. The articles published on classification and resources of commercial fungi are of the same level with similar projects in foreign countries and the identification of key population, cultivation technology of Lactarius

volemus and artificial synthesis of mycorrhiza all reached internationally leading level. The scientific-knowledge campaign accords to the development level in mountainous areas. Generally, this achievement is the first creative outcome in the technological field of commercial fungi, which would play an important role in facilitating and guiding further studies on mycorrhizal edible fungi and the development of wild edible fungi industry in Yunnan.

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Development of Anti-HIV/AIDS Drug, SH Capsule

Type and Class of Award:

Science and Technology Progress of Yunnan Science and Technology Progress Second-class Award

Completion Unit:

Kunming Institute of Botany, Chinese Academy of Sciences

Main Contributors:

Luo Shide, Wang Yifen, Lai Guofang, Cao Jianxin, Wang Lihong, Hao Xiaojian, Ju Peng, Wang Qiong, Wang Yunsong, Zhu Xiangdong, Cao Xujun

Main Contents and Impacts:

Since 1987, this program started screening anti-HIV activity from different parts and solvent extracts of over 1000 species of herbal plants and found that more than 100 herbal plants demonstrated anti-HIV activity, over 20 plants demonstrated strong inhibiting activity. Monomeric compound with strong anti-HIV activity was obtained. Based on such results, several articles and monographs were published, providing references and guidance for HIV/AIDS treatment using traditional medicine and R&D of anti-HIV/AIDS drugs. These publications were as well frequently cited by scholars and scientists engaging in the same field throughout the world. Such studies ensured China’s leading role in the research field of anti-HIV/AIDS drugs and this achievement has been the frontier research that was focused and followed by scientists, both domestic and international. SH capsule with white mulberry root-bark as the main components demonstrated strong anti-HIV/AIDS activity and clinical trials revealed that SH capsule can decrease the virus level significantly and enhance immune function with no distinct side-effects. This achievement enormously enriched the research on anti-HIV/AIDS drugs and made important

contributions to popularizing Traditional Chinese Medicine throughout the world, by means of cooperat ion with America and Thai land and construction of platform for studies on HIV/AIDS and market cooperation. This achievement is leading in studies on development of anti-HIV/AIDS herbal medicine and revolutionarily established the effect-evaluation system and standard of studies of anti-HIV/AIDS herbal medicine. SH capsule now is used in Thailand and tremendous social and economic benefits have been achieved, which received wide recognition and praises there, setting an example for development of TCM in overseas market. This program as well eliminated the doubts on effects of traditional medicine in treatment of HIV/AIDS, advocated that traditional medicine has similar effects with chemical medicine in treatment of HIV/AIDS. Such a program, which has established the guiding principles for fast, high-efficiency clinical trials of traditional medicine, will greatly facilitate the HIV/AIDS researches in China and the whole world.

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6. NEW AND ONGOING NATIONAL RESEARCH PROJECTS

5. SCIENTIFIC PUBLICATION AND PATENT APPLICATION

No. Project Titles Total Fund (million yuan)

Period Categories

1 Gathering, Preservation and Sharing of Important Wild Plant Resources 20 2006-2009 Construction of Sci. &

Tech. Resources Platform

2 Stability Mechanism of Ecosystems of Longitudinal Range-Gorge 3.8 2005-2009 973 Program

3 Medical Chemistry 2 2008-20112007 National Science Fund for Distinguished

Young Scholars

4 Plant Flora and Geography 2 2007-20102006 National Science Fund for Distinguished

Young Scholars

5 Studies on Diversity of Higher Basidiomycetes and the Evolution of Representative Species in Hengduan Mountains Region

1.6 2006-20092005 National Science Fund for Distinguished

Young Scholars

6 Secondary Development of Yunnan Special Dai Ethno Drug, Alstonia controversa 0.6 2007-2010 S&T Support Plan

7 International Cooperation Research on Treatment of HIV/AIDS Using TCM 2 2007-2010 S&T Support Plan

8 Construction of Library (NOVARTIS) of Natural Products 24 2007-2009 International Cooperation

9 Survey and Preservation of Wild Plant Germplasm Resources in Special Habitats of Tibetan Plateau 15 2008-2012 Special Foundation for

S&T Basic Research

10 Evolution and Conservation of Biodiversity in Sino-Himalayan Region 4.46 2007-2010 973 Program

In 2007, a total of 202 SCI-index articles have been published, among which 147 articles were published with KIB as the first author, 34 articles were published on journals of top 15% of relevant subjects. CSCD-index articles published later year number 101, including 56 articles with KIB as the first author. Two papers were included into the first 'One-hundred Most Influential International Scientific Papers in China' sponsored by Ministry of S&T, namely, 'Natural Terphenyls: Developments since 1877' published in Chemical Reviews (2006, 106(6): 2209-2223) by Prof. Liu Jikai and 'Plant Cyclopeptides' published in Chemical Reviews (2006, 106(3): 840-859) by Prof. Tan Ninghua and Prof. Zhou Jun, academician of CAS. In the last year, KIB published four monographs (see Appendix 2), applied for 28 patents with 8 patents being accredited, and registered six national new plant varieties (see Appendix 3)

In 2007, KIB has submitted 150 proposals for research programs at the national and provincial levels and won support for 56 projects with contract value amounting to about RMB 40 million yuan. Of all the programs, KIB presided one special program for basic scientific and technological research, participated in two 973 programs and two scientific and technological support programs with total contracted funds valuing RMB 22.8 million yuan. Other programs undertaken by KIB included 22 National Natural Science Foundation of China, one National Science Fund for Distinguished Young Scholars with contracted funds totaled RMB 8.5 million yuan, and other 28 various programs supported by the S&T Department of Yunnan and the National Development and Reform Commission with contracted funds summed RMB 8 million yuan. New and ongoing national key programs are listed in the following table.

Table 1 New and Ongoing National Key S&T Projects Undertaken in 2007

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7. INTERNATIONAL AND REGIONAL COOPERATION

7.1 International Cooperation Projects Undertaken

7.1.3 Cooperation and Development of Natural Health-care Products

ConductedIn collaboration with Vietnam Xieshi Biotechnological Co., Ltd., KIB carried out the program of 'Studies on Natural Food Additives and Related Health-care Products as well as Charging Commissioned Development', and set up 'Yunnan Botanical Society-Xieshi Excellent Graduates Scholarship' to award excellent incumbent graduate students.

7.1.1 The Fourth Scientific Survey on Plant Diversity in Hengduan Mountain Areas

Completed The fourth Sino-American joint investigation on plant diversity in Hengduan Mountains Area, which is financially supported by National Natural Science Foundation of China and National Science Foundation of USA, was successfully completed. The Sino-American Joint Investigation Team for Plant Diversity in Northwest Sichuan consists of scientists from Harvard University and KIB and the investigation lasted one and a half months and the length of the journal exceeds five thousand kilometers. This investigation has finished the basic material-gathering in weakened and key areas for plant diversity in Northwest Sichuan.

7.1.2 Advances made in the Research of Natural Compounds with Novartis

Inc. KIB sponsored the Annual Meeting for Cooperation Program on July 31st, 2007 with Novartis Inc., a pharmaceutical company based in Switzerland, in order to well fulfill the agreement signed between KIB and Novartis Inc. Dr. Frank Petersen and Dr. Ying Wang from Novartis Inc. attended the meeting. During the past year, KIB has established research team and gradually set up a complete system for research and administration, owing to mutual efforts poured on this cooperation program. The progress achieved will facilitate the development of the program toward a more stable and better orientation.

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7.2 Organizations Jointly Established

7.2.1 Lijiang Alpine Botanical Garden, which is a scientific research platform jointly constructed by Royal Botanic Garden Edinburgh and Kunming Institute of Botany, together with Yunnan Academy of Agricultural Science for biodiversity conservation in Southwest China, started running formally7.2.2 Center for Mountain Ecosystem Studies, which is jointly founded by ICRAF and KIB, plays a very important role in studies on development in Southwest China mountains areas7.2.3 Institute of Tibetan Plateau Research at Kunming has recruited overseas scientists and established innovation research team, starting operations formally7.2.4 The partner laboratory co-founded by the State Key Laboratory of Phytochemistry and Plant Resources in West China and the Chinese University of Hong Kong opens up formally7.2.5 Co-founded the 'Joint Laboratory of Personal Care Products' with the world-leading cosmetics company, Mary Kay, under the provision of Cooperation Confidentiality Agreement7.2.6 The Joint Research Laboratory of Jatropha curcas was founded by cooperation between Singapore Temasek Life Sciences Laboratory and KIB to carry out comprehensive basic researches on the biofuel plant, Jatropha curcas

7.3 International Conferences Sponsored or Co-sponsored by KIB

7.3.1 Sino-Vietnamese Bilateral Meeting on Natural Product and Chemical Medicine, held in Jan. 2007 in Kunming7.3.2 Sino-Germany workshop on Tibetan Plateau Research, held in Apr. 2007 in Kunming 7.3.3 The first International Symposium on China Alpine Wetlands and Climate Changes, held in Jul. 2007 in Kunming 7.3.4 The fifth International Workshop of Edible Mycorrhizal Mushroom, held in Chuxiong in Aug. 20077.3.5 International Workshop on Protection of Traditional Knowledge, held in Kunming in Aug. 2007

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7.4 Selected Foreign Affair Activities

In 2007, KIB has handled the formalities for 20 academic visits to foreign countries and for four special visits to China of five foreigners. The number of joint field investigations claimed is 15 and personal times of reception for visits to KIB numbered 287. Main foreign affair activities undertaken:

7.4.1 Delegation of Vietnam Academy of Sciences visited KIB to attend the Sino-Vietnamese Bilateral Meeting on Natural Product and Chemical Medicine, and signed cooperation agreement with KIB

7.4.2 Delegation of Graduate Students Education from Wisconsin University visited KIB and signed a cooperation agreement on joint education of graduate students

7.4.3 Prof. Zheng Yongqi, a pharmacologist from Yale University visited KIB

7.4.4 Delegation of Institute of Chinese Medicine, the Chinese University of Hong Kong visited KIB and signed a cooperation agreement

7.4.5 Delegation of Department of Hill Tracts, Chittagong, Bangladesh visited KIB

7.4.6 A delegation consisting of four members headed by vice director of U.S. National Science Foundation visited KIB

7.4.7 Experts from Department of Arts and Design of Rove City University held the Arts and Science Popularization Expo at KIB

7.4.8 A delegation consisting 12 members including president of Hai-O Group and Golden Hope Group of Malaysia visited KIB

7.4.9 Scientists from Research Institute of Ecological and Biological Resources of Vietnam Academy of Sciences visited KIB and carried out a 10-day cooperation program

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7.4.10 A delegation consisting of six members from Singapore Temasek Life Sciences Laboratory visited KIB and signed a cooperation agreement

7.4.11 A delegation consisting four members of the Preparation Office of Bonn Program of Ministry of Foreign Affairs of China visited KIB

7.4.12 A delegation consisting four members of Queen's Botanical Gardens of Thailand visited KIB

7.4.13 Students delegation consisting seven members from Keio University of Japan visited KIB

7.4.14 A delegation consisting four members headed by director of Korean Sunchon National University visited KIB and signed a cooperation agreement

7.4.15 A delegation consisting of four members headed by the director of National Institute of Biological Resources of Korea visited KIB and signed a cooperation agreement

7.4.16 A delegation consisting of three members headed by director of Korean Industry Promotion Agency visited KIB and signed a cooperation agreement

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7.5 Cooperation Programs with Enterprises

7.5.1 Signed a cooperation agreement with Yunnan Yuanyi Garden Engineering Co., Ltd., focusing on studies on grafting and propagation of camellia and industrialization development of cypripedium plants. According to the agreement that will last four years, mutual parties of the agreement will share the interest pro rata. 7.5.2 Signed the supplemental agreement with Yunnan Spirin Bioengineering Co., Ltd. for further studies of Erigerontis injection on basis of previous cooperation program. The company provided additional RMB two million yuan for more profound studies with a period of four years.7.5.3 Signed a cooperation agreement with Yuan Jinbiao Biotechnoloy Co., Ltd., which provided a fund valuing RMB two million, to carry out R&D of anti-depression drugs.7.5.4 KIB signed a cooperation agreement with independent Yunna Jiyuan Biotechnolog Co., Ltd., which provided a fund valuing RMB 80 thousand, to carry out breeding and improvement of taxus varieties.7.5.5 Carried out the program of scientific surveys on selected plant resources in Yulong Snow Mountain Natural Reserve with fund amounting to RMB 0.32 million yuan. The program was commissioned by Administration Commission of Yunnan provincial natural reserve, Yulong Snow Mountain Natural Reserve of Yulong County, Yunnan.

7.5.6 Conducted the program of studies on raw materials of Weimaining and modif ication of quality standards commissioned by Zhejiang Huayi Pharmaceutical Co., Ltd.7.5.7 Conducted the program with contracted fund valuing RMB 250 thousand yuan, which is commissioned by Jiyuan Jishi Pharmaceutical Co.,Ltd., Henan, focusing on R&D of anti-tumor drugs, total diterpene extracted from Rabdosia rubenscens. 7.5.8 Carr ied out a research program with contracted fund totaled RMB 220 thousand, which is commissioned by Yunnan Jinsha River Hydropower Co., Ltd., focusing on influences and evaluation of flooding project of Liyuan Hydropower Station Reservoir on the biodiversity in Yulong Snow Mountain Natural Reserve and Harba Snow Mountain Natural Reserve. 7.5.9 Carr ied out a research program with contracted fund totaled RMB 200 thousand, which is commissioned by Ninglang Bureau of Transportation, focusing on influences and evaluation of reconstruction project of Ninglu highway on the biodiversity in Luguhu Lake Natural Reserve.

7.6 Transfer of Achievements7.6.1 The new rhododendron cultivars, Xilinmen and Jiaoyan were sold to Yunnan Green-Land Biological Technology Co., Ltd. at price of RMB 300 thousand yuan. 7.6.2 Crude medicine of cepharanthine hydrochloride and approval document for clinical trials of cepharanthine hydrochloride injection were sold to Dali Pharmaceutical Co.,Ltd. at price of RMB six million.

7.7 KIB Shareholding Enterprises7.7.1 Yunnan Green-Land Biological Technology Co., Ltd.Relying on its own competitiveness and great potential for future development, KIB shareholding enterprise Yunnan Green-Land Biological Technology Co., Ltd. was successfully listed in the Shenzhen Stock Exchange with approval for public offering of A-shares from China Securities Regulatory Commission. The main businesses of the Company include seedling production and sale of greening plants, as well as designing and undertaking of greening engineering projects with total 62.9373 million shares and shareholding ratio of KIB is 10.66% with market value exceeding RMB 400 million yuan. Yunnan Green-Land Biological Technology Co., Ltd. is the first KIB shareholding enterprise that has been listed in the stock market, which set an excellent paradigm for transfer and industrialization of scientific research achievements at KIB. It also provides valuable experience and reference for KIB in facilitating industrialization.

7.7.2 Yunnan BioBioPha Co.,Ltd. Due to KIB’s advantages in phytochemistry scientific research and State Key Laboratory of Phytochemistry and Plant Resources in West China, KIB successfully won private investment valuing RMB 20 million and established the Yunnan BioBioPha Co.,Ltd. with registered capital totaled RMB 23 million. Depending on technology appraised as capital stock, KIB possesses 13% of the total shares. The main businesses of the company include R&D and utilization of natural activity. The founding of Yunnan BioBioPha Co.,Ltd., which is a new trial for KIB to accelerate industrialization using technology advantages, provides an ideal platform for industrialized transfer of KIB’s research achievements.

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8. CONSTRUCTION OF TALENTS TEAM AND SCIENTIFIC RESEARCH PLATFORMS

8.1 Breakthrough Made in Construction of High-level Talents Team

KIB fully utilized the resources and properly selected research fields according to actual discipline structure and requirements for further development. KIB has poured strenuous efforts to create a favorable environment for talents with preferable policies and implemented the talent-recruiting strategy to welcome excellent scientists.

8.1.1 Dr. Li Weiqi was recruited into the 'Hundreds of Talents Program' of the CAS

Dr. Li Weiqi graduated from the Chemistry Department of Beijing Normal University with a bachelor’s degree in Jun. 1983, and obtained his Master Degree and Ph.D. from Department of Biochemistry of Kansas State University, USA in Dec. 2002 and Dec. 2004, respectively. His doctoral dissertation was successively published on Nature Biotechnology (impact factor = 17) and Journal of Biological Chemistry (impact factor = 6), which earned him four awards in praising his marked contribution to the fields of biochemistry, molecular biology and lipids given by the universities or academic schools in America. In 2005, Dr. Li was recruited into KIB as a 'Hundreds of Talents Program' scientist and passed the 2007 annual examination for 'Hundreds of Talents Program'. In 2007, one of his papers was online published on the Journal of Biological Chemistry and was rated as one of the outstanding scientific achievements of China Mainland and Hong Kong by the magazine of Nature China . As a co-author, Dr. Li also published another two SCI-index papers. In 2007, the research group led by Dr. Li successfully applied for two programs, one subproject of the 973 Program and

one subproject for national scientific and technological basic platform with funds totaled about RMB 800 thousand. There are two graduate students and two doctoral students now working at Dr. Li’s research group.

8.1.2 Prof. Tan Ninghua Won Support of National Science Fund for Distinguished Young Scholars

Prof. Tan Ninghua graduated from Guizhou Medical College in 1984 and acquired her Master Degree and Ph.D. from China Pharmaceutical University. Upon completion of post-doctoral programs at KIB, she chose to work here and once carried out cooperation research projects in Germany (1996), the United States (1998) and Australia (2006) as a visiting scholar. She was selected to be a young and middle-aged senior scientist of Yunnan, scientist of CAS Western Light Talents Program and laureate of National Science Fund for Distinguished Young Scholars in 1997, 2004 and 2007, respectively. Prof. Tan, who currently is the vice chair of the State Key Laboratory of Phytochemistry and Plant Resources in West China, has published a total of more than 140 papers including over 60 papers in SCI-index journals such as Chemical Reviews and Organic Letters , and seven monographs. As the laureate of the first-class prize of Yunnan Natural Science Award, Prof. Tan has preside over 20 research programs and organized two international conferences. She is now an editor of Journal of Integrative Plant Biology and her research fields ranging chemistry of natural drugs, pharmacology and medicinal design, and her research interest lies in cyclopeptide.

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8.1.3 Prof. Sun Hang Awarded 2007 State Class New Century Hundred-Thousand-Ten Thousand

Talents Project Candidate

8.1.4 Dr. Gao Lizhi, a Newly-Recruited Overseas Outstanding Talent Applied to be CAS 'Hundreds of

Talents Program'

Dr. Gao Lizhi obtained Bachelor of Science from Department of Biology of Yunnan University in 1991 and PhD from CAS Institute of Botany, under direction of Prof. Hong Deyuan, a CAS academician in 1997. And under direction of Prof. Dong Yuchen, an academician of Chinese Academy of Agricultural Sciences, he completed his post-doctoral researching program in 1999. Dr. Gao was once awarded the Vavilov-Frankel prize by IPGRI affiliated to FAO in 1999. From 1999 to 2004, Dr. Gao successively carried out post-doctoral studies at Department of Biology, Washington University in St. Louis, Department of Genetics of Georgia University, Department of Ecology and Evolution Biology of Michigan State University, the Center for Human Genetics, Texas University Huston Campus. And since 2005, he worked at Huston University as an assistant professor. In 2006, Dr. Gao was recruited into KIB as 'Hundreds of Talents Program' scientist. He is presently the chair of the Center of Plant Germplasm and Genomics. Dr. Gao has made globally-recognized contributions to studies on population genetics, molecular ecology and conservation genetics of Oryza rufipogon. Through studies on genomes of model species including rice, arabidopsis thaliana, poplar, microzyme, human and mouse and using technologies of genomics and bioinformatics, Dr. Gao has carried out studies on a series of important problems of evolution biology and ecology, such as the contribution of gene duplication (including polyploid) and transposon in structure, evolution and function of plant genomics, and achieved some unique results since 2000. Dr. Gao now is dedicating his efforts to the sequencing of genomes of Oryza rufipogon and Camellia sinensis. As the first author or corresponding author, Dr. Gao has published over 40 papers on many world-leading journals such as Science. He is a peer reviewer for over 20 SCI-index academic journals.

Born in Dec. 1963, Prof. Sun Hang graduated from Yunnan University in Jul. 1983 and obtained his Master's Degree and PhD from KIB in 1988 and 1994, respectively. Prof. Sun now is the Deputy Director of KIB and Secretary of KIB CPC Committee. He has received numerous awards and honors including CAS Zhu Kezhen Scientific Fieldwork Award, second-class prize of CAS Natural Science Award, etc. Scientific programs Prof. Sun has undertaken include three National Natural Science Foundation Program, one Key Program, Key International Cooperation Program, one National Science Fund for Distinguished Young Scholars Program, one key program specially supported by CAS Special Foundation, one CAS Innovation Orientation Program and one Special Program of Basic Research of Ministry of S&T. The number of papers he has published on core domestic and international journals exceeded 60. In addition, Prof. Sun has authored or co-authored six monographs.

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8.1.5 Four Excellent Overseas Scientists with Average Age of 33 Recruited and Entitled as Professors

Born in 1973, Dr. Hu Xiangyang graduated from Anhui University with major of Biochemistry, and acquired his Master’s Degree and Ph.D. from Shanghai Institute of Plant Physiology and Ecology through master-doctor combined program. Later on, Dr. Hu carried out postdoctoral researches at University of California (Riverside) and John Innes Center, Norwich, UK. In Jul. 2007, Dr. Hu was recruited to Institute of Tibetan Plateau Research at Kunming. He has published many papers on preeminent journals including Molecular Cell Biology, Plant Physiology, Plant Cell Physiology, Cell Research, Science in China and Chinese Science Bulletin. Dr. Hu mainly concentrates his researches on plant stress adaptation and molecular mechanism of evolution including the following aspects:1) Screening of Arabidopsis mutants sensitive to stresses such as salt, drought, freezing and high ultraviolet radiation and cloning of important functional genes2) Molecular mechanism of plant adaptation and evolution under extreme stresses in Qinghai-Tibetan Plateau areas, and cloning and analyzing of important functional genes3) Accumulation of secondary products resulted from response of medical plants to stresses and expression of relative genes

Born in 1973, Dr. Guo Zhenhua graduated from Department of Biology of Liaocheng University, Shandong in 1997, and acquired her Master’s Degree and Ph.D. from KIB through master-doctor combined program in 2002. From 2002 to 2006, Dr. Guo carried out postdoctoral researches at East Carolina University, USA, focusing studies on bioinformatics and comparative genomics. Later on, Dr. Guo undertook postdoctoral studies on technologies of biochip and expression models of cellular senescence associated genes at Yale University from Mar. 2006 to Jul. 2007. In Aug. 2007, Dr. Guo was recruited in the research group for the Southwest China Germplasm Bank of Wild Species, engaging in studies on molecular systematics and molecular evolution and comparative and functional genomics. She has published over

10 papers and co-authored two monographs, among which five papers were published on mainstream journals in the field of evolution biology and relative interdisciplinary subjects such as Molecular Biology and Evolution, BMC Genomics, Molecular Phylogenetics and Evolution and Journal of Plant Research, etc. In terms of research programs undertaken, Dr. Guo once preside one National Natural Science Foundation Program and one Yunnan Natural Science Foundation Program.

Dr. Li Shenghong graduated from Department of Chemistry of Yunnan University, in 1996, and acquired his Ph.D. from the State Key Laboratory of Phytochemistry and Plant Resources in West China of KIB, where Dr. Li began his work as a research assistant. In Apr. 2003, Dr. Li was promoted to be an associate professor and carried postdoctoral studies at Chinese Medicine Institute of The Chinese University of Hong Kong from Mar. to Sep. 2004. Concentrating on studies of chemical identification of phenolic defensive components in Picea abies and of their orientation in special cells, Dr. Li carried out postdoctoral research at Max Planck Institute for Chemical Ecology, Germany from Oct. 2004 to Jan. 2008. Dr. Li is the first scientist in the world who studies the plant cellular secondary products using the combined method of laser microdissection and cryogenic NMR. Based on the research results, Dr. Li found that it’s evident that some phenolic compounds involved with plant cellular defensive mechanism.

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He has published over 60 papers in international and domestic core journals, most of which are SCI-index ones. Dr. Li has applied for one patents and also obtained the patent approval. He has presided and completed one National Natural Science Foundation Program and one Yunnan Natural Science Foundation Program. In 2002, Dr. Li received the first-class of Yunnan Natural Science Award (the sixth participant) and was chosen to be 'Yunnan Young and Middle-aged Senior Scientist' candidate of the sixth batch in 2003. Dr. Li won the Humboldt Foundation research fellowship from 2005 to 2007, and was recruited in the State Key Laboratory of Phytochemistry and Plant Resources in West China, focusing on studies on chemical ecology of plant secondary products.

Born in 1974, Dr. Li Yan graduated from School of Life Sciences, Shandong University in 1995, and acquired her Master Degree in cell biology from Shandong University in 1998 with degree dissertation study of the anti-tumor and anti-ageing activities of components extracted from natural plants and alga. From 1999 to 2002, Dr. Li carried out studies for her Ph.D. and postdoctoral research at DKFZ, Germany. In 2001, she acquired her PhD degree from Shandong University and her dissertation mainly focused on WNT signaling pathway and the mechanism to modulate early head development and differentiation of embryo. In 2003, she began her postdoctoral training at CCHMC, USA, concentrating on the regulatory mechanism of WNT signaling during the early development of digestive system. In 2007, Dr. Li was recruited to the State Key Laboratory of Phytochemistry and Plant Resources in West China, KIB. The main tasks of her research group are screening natural products with bio-activities and conducting further mechanism studies in the field of molecular signaling pathways. The work will lead to discovering of small molecules as probes to explore further the signaling pathways closely related to human diseases and discovering medical leading compounds and/or efficient drug targets in treatment of tumor and other diseases.

In 2007, KIB recruited five doctors for post-doctoral training including one foreign doctor, two senior visiting scientists, one 'Western Light' visiting scholar (Jiang Siping) and one fellow (Ni Zhen) for scientific and technological administration. Meanwhile, KIB sent a member (Yu Fuqiang) of 'Service Group of Doctors' to Bureau of Forestry of Diqing as the deputy director general. Dr. Shui Yumin obtained post-program support from the 'Western Light Program'. Six scientists from KIB won support from the 'Western Light Program' and the applications for program supporting doctors in Western China in 2006 and 2007 have been completed. Fourteen scientists from KIB won support of this program with fund totaled RMB 2.44 million yuan.

Others

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8.2 Construction of Platform for Scientific Research

8.2.1 Phytochemistry Analyzing and Testing Center

The KIB Analysis and Test Center owns first-class, large- and intermediate-sized facilities in China for chemical research on natural drugs. The center has passed the Yunnan Computation Accreditation and has established the chemistry library of natural products and platform for screening drugs. The center is capable of providing 26611 maps, 127 reports of metrology accreditation every year and the annual revenue amounts to RMB 1.76 million yuan. The center strictly adheres to the tenets of 'open to the institute and the entire society, and serve the institute and the entire society', playing an active role in technological innovation, international cooperation and education & training apart from routine work. In 2007, the Center has successfully completed the tasks with high-quality services and distinguished performances.

8.2.2 Herbarium (KUN)

After reconstruction, Herbarium (KUN) now is capable of preserving over four million specimens. The number of specimens preserved at the Herbarium of lichens, large fungi, bryophytes, ferns and seed plants amounts to 1.2 million by 2007 and the data of all type specimens and 1/4 of all the specimens have been made available on the Internet. New accessions of specimens at the Herbarium was 23028 in 2007, and the reception times of visitors from home and abroad amounted to 1400. Besides, over 2000 specimens have been exchanged with other large hebaria. Furthermore, a total of 2000 specimens have been identified and 4897 specimens are collected. Besides routine job, workers in the Herbarium also apply for funds, presides programs and contributes papers. In 2007, the personnle of Herbarium has translated one monograph and published 12 papers, including five SCI-index papers and five CSCD papers.

8.2.3 The Southwest China Germplasm Bank of Wild Species

The Southwest China Germplasm Bank of Wild Species is one of the three major organizations for conservation of important plant species in the world. By the end of 2007, the total investment of the program is RMB 148 million yuan with amount of counterpart funds in position numbering RMB 141 million. Accumulated investment implemented amounted to 100.27 million and the investment for 2007 was 26.69 million. The projects for main body and infrastructural construction have passed the acceptance evaluation. The installation and testing of seed-preservation facilities of the underground warehouse (refrigeratory/drying room) have already been completed and put into use. Public bidding invitation and procurement of main facilities for studies on plant genomics and construction of DNA library has been finished and research platform for plant genomics been constructed. The testing for fire-fighting facilities and electric detection have been completed and the certificate been obtained. Acceptance examination of fire-fighting will be undertaken in near future and the totally automatic steel-structure green house is under construction. In companied with the construction the application for approvals of field gathering and specimen collecting has been completed. In 2007, the gathering of seeds, data, specimens and images of a total of 13708 accessions of wild plant species has been finished, 1200 accessions of seeds been received and exchanged. And 2326 accessions of seeds have been identified and 194 accessions of seed samples have been sent as materials and data resources for scientific studies. Through the program platform established, 34 volunteers for seed gathers were able to receive trainings and several social practices have been carried out here including practices of the Departments of Biology of Wuhan and Tsinghua Universities.

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8.2.4 The Horticulture Center

A total of 667 additional plant taxa have been introduced by the supporting system of KIB Botanical Garden, and the seed exchange between Chinese and foreign botanical gardens has been resumed after years of intermitting. Over 40 thousand seeds from more than 50 populations of Jatropha curcas as well as 2500 living plantlets and saplings have been collected and preserved at the center. The construction of 'Ornamental Foliage and Fruit Plants Garden' occupying an area of 2.4 ha has been completed and opened to the public. The garden is consisting of nine functional sections, and some 140 thousand plants belonging to 415 taxa, 260 genera and 116 families have been planted and exhibited. The gate construction of the station, crawls and a 400 m2 greenhouse has been completed at Lijiang Alpine Botanical Garden, where precise management and maintenances of garden of an area exceeding 400 mu was performed. The provisions and rules have also been perfected, enduring the safety and order of visits of 416 thousand visitors during the year. In addition, a series of science-popularization activities have been successfully held, such as CAS Public Science Day, National Science Popularization Day and secretes of green leaves, etc. All activities were brought to audience of millions of thousands through coverage and reports by TV and newspapers.The website of the Botanical Garden has been founded and the main plant taxa of different sections or featured gardens have being made available for online searching by means of listing these plants into a specific column. The workshops on construction

of Botanical Garden and their management has been well organized and initiated, and the translation of a famous monograph concerning plant field survey, 'George Forrest-Plant Hunter' has also been completed. Inddition, a total of 1039 plant labels ranked the international standard level were made and placed on the plants at the Botanical Garden.

8.2.5 Scientific & Techological Information Center

In 2007, the information center strengthened the planning, construction and management of websites at different levels, successfully implementing the self-created networking information security supervision system. The networking U disk storing system worked normally and regular check up and service for computer security maintenance were carried out. The center endured the normal running of ARP system and security of the data, and successfully deployed V1.0 the searching system. The information center made huge amounts of videos and multimedia materials for Prof. Wu Zhengyi’s application for the state supreme scientific and technological award. The center as well set a service area of information resource and steady progress have been made for the journal, Acta Botanica Yunnanica. In 2007, the Botanical Society of Yunnan has raised a foundation valuing RMB 180 thousand and the running of the society is towering a correct direction. The aforementioned efforts and endeavors made by the center enormously guarantee the researching personnel using the Internet more conveniently and safely and the center provided more convenient, faster services, saving significant costs for the institute. In summary, the Center well played its role of providing support and service.

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9. CONSTRUCTION OF INNOVATIVE CULTURE AND

9.1 Infrastructure Projects during 'Tenth-Five' and Two Major Projects Passed Acceptance Examination

Infrastructure projects during 'tenth-five' period of KIB already entered the ending stage. As an important part of Knowledge Innovation Program, the program management team of infrastructure program fully respected the suggestions of varied departments, accepted consciously the supervision of the Workers’ Union and discipline inspection, handled the affairs strictly according to the basic procedures and strictly controlled the proceeding, quality and investment of the projects so as to ensure the KIB infrastructure project to proceed steadily and investment to be launched safely. On Sep. 17th, the newly-built comprehensive building for scientific research and reconstruction project of the state key laboratory successfully passed the professional acceptance examination sponsored by CAS Bureau of Infrastructure Projects, symbolizing that the infrastructure projects of the second-phase Knowledge Innovation Program in providing hardware support for scientific research activities has been further reinforced and recognized. The achievement of infrastructure projects of KIB is a result of combination of full support from KIB leaders and KIB Infrastructure Projects Leaders’ Group, standardized operation and strict management of the projects,collaborations

9.2 KIB Maintained its Leading Role in Public Affairs and Propagandas in CASRelying on various efforts and advantages of CAS members, experts and provincial and national committee of CPPCC and deputy of the People’s Congress, KIB managed to provide services and suggestions for democratic decision-making of the government, sticking to legal administration and strengthening administrative supervision, actively forwarding advice and suggestions for social, economic and S&T development of local areas. In addition, we reported honestly to CAS and government of different levels on public affairs of the CPC committee at KIB and innovations achieved. In 2007, the public affairs work in 2007 maintained a satisfying development trend and scored 332, which is ranked No.9 among the 142 institutions of CAS. KIB was rated as an 'Outstanding Institution' in propagandizing information about implementation of CAS public affairs management standards. Of all the information concerning public affairs management reported by KIB in 2007, 103 pieces of information were adopted by CAS Office and CAS website including 8 pieces of information further forwarded by CAS Office to CAS Special Reported Information, 4 pieces of information adopted by the Office of CPC Central Committee or Office of the State Council, two pieces of information included into Top Leader Reference Materials, one instruction given by CAS leaders, two issues of Innovation Newsletter, and 88 pieces of information cited by CAS website. As for propagandas work, KIB as well holds a leading role in CAS. By Dec. 30th, 2007, the statistical information concerning the ranking of institutions in terms of news release a n d p r o p a g a n d a s revealed that KIB was ranked No. 3 with total accumulative number of news amounting to 82 and accumulative s co re o f 299 . The General Administrative Of f i ce successfu l ly initiated and organized the propagandas work and news cover ing of many important activities occurred at

MANAGEMENT SYSTEM

among different parties, sticking to planning and accounting principles and construction of incorruption culture and construction in civilization.

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9.3 Effectively Implementing CAS Public Affairs Management Standards

KIB, such as project completion ceremony, application for the state supreme scientific and technological award and inception meeting for editing of Biology Volumes of the Great Encyclopedia of China. Such work greatly expanded KIB’s social influence, creating an irreplaceable image of KIB in research field of use and protection of plant resources in China and successfully popularizing the research achievements of KIB.

CAS proposed and fully implemented the public affairs m a n a g e m e n t which is another impor tan t wo rk o f management innovat ion after the deployment of ARP system, and also an important measure for fulfillment of 'four first-class' CAS and for accelerating the standardized and scientific management. KIB added the work of implementing the CAS public affairs management standards into the schedule of public affairs at KIB. With particular attention from KIB leaders, ful l support and coordination among different departments, the entire work was carried out effectively and orderly. Owing to strenuous efforts, KIB even made improvements and adjustments in responses to the advice and suggestions made during systematic inspection and eventually, KIB reached two CAS first-class standards in terms of security management and information propagandas, two CAS second-class standards in archive processing and filing management, respectively. KIB was as well rated as an 'Outstanding Institution' in propagandizing information about implementation of CAS public affairs management standards, and in assets checking.

As an important measure for management innovation during the third-phase Knowledge Innovation Program of CAS, the implementation of CAS public affairs management standards would certainly facilitate the construction of management system of modern institutions with more standardized and effective public affairs management, continually making basic, strategic and forecasting contributions of great significance to national economic development and infrastructure.

9.4 Outstanding Individuals and Organizations Emerging Continuously in the Institutionalized and Innovative Culture ConstructionResulted from unrelenting scientific practice and intellectual development of several generations of scientists, the spiritual culture of KIB can never be established in short time, but involves scores of years’ accumulation and development. Due to integral efforts made by both the staff and graduate students, the excellent tradition, will character and thought realm of KIB have been forwarded improved and reinforced. And all of us will made due contributions to construction of innovation culture of KIB. Prof. Hao Xiaojiang won the honor of 'Outstanding Individual in the Third CAS Innovation Culture Construction'. On Mar. 21st, 2007, deputy secretary of CPC Branch Committee of CAS announced the 'Resolution Concerning Awarding the Outstanding Institutions and Individuals in the Third CAS Innovation Culture Construction'. A total of 10 institutions won the honor of 'Outstanding Institution in the Third CAS Innovation Culture Construction' and 21 persons won the honor of 'Outstanding Individual in the Third CAS Innovation Culture Construction'. Encouraging by the spirit of outstanding institution and individuals, both the leaders and employees of KIB would commit to

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38 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

the great practice of scientific innovation and create an innovative, competitive, collaborative and harmonious cultural environment, making continuous contribution to construction of a innovative, ambitious and harmonious CAS. The research group of origin and evolution of alpine flora of KIB won the honor of 'Outstanding Group in Innovation Culture Construction CAS Kunming Branch' and Prof. Hu Hong and Ms. Yin Wen won the honor of 'Outstanding Individual in Innovation Culture Construction CAS Kunming Branch.

9.5 Strengthen Regulation Construction and Standardized Management

In order to meet the requirements of 'four first-class' proposed by Chinese President, Hu Jintao for prospective development of CAS and on basis of the tenet of 'founding the institute scientifically, running it by law and st rengthen ing i t by moral virtues'. KIB has gradually established a n d c o m p l e t e d a

just, efficient and meticulous management system that perfectly matches the operation mechanism and management system of goals for innovation development of KIB. Based on the previous regulations, the General Administrative Office completed the compilation of 'Document Assembly of Regulations of KIB (volume A)' (hereinafter abbreviated as the Assembly), through abolishing, modifications and supplementations. The Assembly consists of 12 parts, namely, public affairs management, organization and structure, scientific research management, personal affairs education management, talents cultivation, information popularization and management, archives management, infrastructure and real estate management, finance and capital management, logistics management, securing and safeguard management and department management. The Assembly main contains 127 effective regulations prescribed by different departments from 1996 to 2007. The Assembly advocates the management thoughts of hierarchical management, fair and open, realistic and innovative with characteristics of guidance, standardization and feasibility. The Assembly is an important guarantee for law-based management, and

9.6 Institute-level ARP System Successfully Upgraded and the Second-phase Program under Preparation

The institute-level Academic Resource Planning (ARP) system has been successfully upgraded, providing high-level platform for the institute’s management innovation. To date, the ARP System has already proved to be effective in management, statistical accuracy, time inquiries, integral information and data sharing. Through continuous practice and testing, the ultimate goal of scientific decision-making, optimum resources configuration, collaboration of management and normalization of workflow and sharing of information will be achieved. KIB has carried out an investigation on general execution plan of ARP System the second-phase, pointing out various problems existing in the current system and proposing suggestions for optimization of the system and requirement for innovation management. In addition, the investigation report concerning the implementation of the second-phase of ARP System has been compiled, contributing to the increasing completion of ARP System. Some of the problems identified about the ARP system have already been resolved through deployment and implementation of upgrade of ARP System V1.1 version. On basis of the mature experience of the first-phase, special efforts would be concentrated on reinforcing collaborations and

behavior guide lines to encourage all the workers to fulfill the knowledge innovation goals, which would play an positive role in terms of increasing management efficiency and work quality and of creating a favorable environment for scientific research and a civilized working environment. With the development of KIB, the Assembly will be further revised accordingly, toward the goal of 'first-class management'.

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39Annual Report 2007

9.7 Acceptation Examination of First-Stage Archive Collection to CAS Successfully Completed

Archives collection is a complicated, integral project for every institution and KIB, as an important constitutional part of CAS, is obliged to carry out the work of archives collecting according to the Archives Law, guaranteeing the integrity and accuracy of historic recordings of KIB as well as CAS. Archives of CAS is the permanent base preserving materials of real history and development procedures of CAS as well as its affiliated institutions, and the center of providing useful information for all circles of the society with diversified purposes. In order to build up a scientific preservation system of Archives of CAS, it’s the prerequisite to collect various archives with historic proof function and scientific research value from all the institutions with their own archives to assure of sufficient archives, accumulation of information resources and availability of useful information of the Archives of CAS. It’s also the obligatory task for every institution affiliated to CAS. The acceptance examination of KIB’s archives collection, which was sponsored by an evaluation group consisting four members including Director of Achieves

interactions among different departments, on combination of practice and application and on training, during the execution of the second-phase ARP System.

of CAS, was held on Apr. 10th, 2007. During the examination, the scopes of archives collection, quality for archival description and compilation of retrieval tools for various archives before 1980 collected at KIB Archives were carefully inspected. The evaluation group deemed that the archives accorded to relative standards and requirements and can be preserved at the Archives of CAS.

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40 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

Director:LI De-ZhuDeputy Directors:SUN HangYANG Yong-PingLIU Ji-KaiGAN Fan-YuanDirector Emeritus: WU Zheng-Yi

General Administrative OfficeGAN Fan-Yuan (Head, Concurrent post)QIAN Jie (Deputy Head)XIONG De-HuaZHAO Ji-DongTIAN Zhi-DuanHUANG Lu-LuWU YanYANG Song

Division of Human Resources, CPC & Education AffairsWU Shu-Guang (Head)LI YingZENG Yan-MeiYIN WenLI Jiang-WeiWU Shao-BoPU Ying-DongHE Hai-yanHUA Hong-Ying

Division of Science and Development WANG Yu-Hua (Head)LI Zhi-JianMA Xiao-QingYUE Yuan-ZhengLI Xiao-XianTIAN NingNI Jing-Yun

Division of Assets and Finance Management (combined with Division of Science and Development to be Division of Science, Development, Assets and Finance Management in July 2007, with WANG Yu-Wang as the Division Head)

ZHANG Ying-Jue (Acting Head, till June 2007)YANG Ge-LanHAN MinWANG YingXUAN YuDUAN Jun-HongGU Shuang-HuaHU Bin

Sci. & Tech. Information CenterZHOU Bing (Chief Executive)LIU Ai-QinZHOU Yi-LanDU NingHE Yan-BiaoHE Yun-ChengYANG Qian (till May 2007)LI Tuo-Jing (Since in July 2007)

Biogeography and Ecology DepartmentHead: ZHOU Zhe-KunDeputy Head: PENG Hua

CAS Key Laboratory of Biodiversity and BiogeographyDirector: SUN Hang (Concurrent post)

Executive Director: ZHOU Zhe-KunInnovation Base Consultant: WU Zheng-YiYANG Yun-Shan (Secretary to Academicians)

LI De-Zhu’s Group:LI De-ZhuWANG HongYANG Jun-BoXUE Chun-YingGAO Lian-MingLU Jin-MeiYU Wen-Bin (since July 2007)

LIU Pei-Gui’s Group:LIU Pei-GuiZHANG Chang-QinWANG Xiang-HuaYU Fu-QiangZHANG Jing-Li (since in July 2007)

SUN Hang’s Group:SUN HangNIE Ze-LongYue Ji-PeiZHA Hong-Guang (since September 2007)CHEN Lin-Yang (since October 2007)

YANG Zhu-Liang’s Group:YANG Zhu-LiangZHANG Li-FangWANG LanZHANG Ping

ZHOU Zhe-Kun’s Group:ZHOU Zhe-KunCHEN Shao-TianJI Yun-HengCHEN Wen-Yun

The Herbarium (KUN)PENG Hua (Curator)LEI Li-GongWANG Li-SongLI Xue-DongWANG Jing-HuaZHANG YanWANG LinXIANG Jian-YingLIU En-DeWU Xi-Lin (retired November 2007)ZHOU Hong-Xia (till May 2007)

Other Members:SHUI Yu-MinYANG Shi-XiongHU Yun-QianCHEN Wen-HongYANG XueCAI Jie

APPENDIX 1: STAFF AND STUDENTS

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WEN Ning WEN Yi-Lin

Master’s Students (37):FANG WeiREN Zong-Xin LIU JieZHANG Yu-XiaoAI Hong-LianZHANG ShuZHOU WeiDENG Xiao-JuanTIAN Xiao-FeiMA Yong-PengSHEN MinNIU YangYUE Liang-LiangFENG BangSU TaoYU Wen-TaoXU JinDONG Zhao-HuiYANG JieZHANG Rong-MeiZHAO Hou-TaoXU Ping-ZhenWU Yan-MinMA Peng-FeiHUANG Yong-JiangDONG Hong-JinZHANG Yun-JieHUANG Pan-HuiJIANG WeiZHAO Dong-WeiSHI Xiao-FeiDU Xi-HuiZHAI Yan-HongXIE Xue-DanWANG NianYIN Zhi-JianXI Xue Ph.D. Students (44):QIAN Zi-GangZHANG Xue-MeiWANG QunZHANG Shu-DongZENG Chun-XiaLI Zhong-Rong LU LuWEI Zhi-DanXU HongDONG Li-NaWU Shun-YuLI Su-MeiWEI Hai-LeiWU Zhi-KunGAO Ze-RuiSUN Bao-LingZHANG Da-CaiTU Tie-YaoZHANG Yong-HongZHANG Jian-WenCHEN GaoYANG YangZHANG Ti-CaoGE Zai-Wei

YUAN LiYANG Qing-SongLIU Meng-QiXING Yao-WuPU Chun-XiaLIU Zhen-WenXIA KeGAO QianLI Yan-ChunXIANG Chun-LeiQIAO QinTIAN WeiZHOU JingZHANG Yu-XiaoLIU Yan-ChunYANG YingZHU Wei-DongHE JunZHANG De-QuanTANG Li-Ping

Laboratory of Ethnobotany Head:YANG Yong-Ping (Concurrent Post)

YANG Yong-Ping’s Group:YANG Yong-PingFU YaoLI Xiao-Li

LONG Chun-Lin’s Group:LONG Chun-LinWANG Yue-HuHUANG YuanLUO Ji-Feng LIU Yi-TaoHiromichi YOSHINOLI RongLIU Yuan

XU Jian-Chu’s Group:XU Jian-ChuYANG Xue-FeiGAO FengLI Qiao-HongGAO FuYANG Jian-KunLI Hai-Tao

Other members:DAO Zhi-LingWANG Kang-LinYANG Li-XinYANG Zhi-WeiZHANG Guo-XueWANG Jie-RuXIE Hong-YanLI Dong-Sheng

Master’s Students(18):FAN Deng-MeiZHAO FangLI YangYI JinWANG XiLI Xin-HuiLI Mao-Lin

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42 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

LI Yan-MeiDI Ying-HongNI WeiLIU Hai-Yang

LIU Ji-Kai’s Group:LIU Ji-KaiDING Zhi-HuiLI BoDONG Ze-JunXU Di (Senior visiting scholar)ZHANG Yi(Secretary)

LUO Shi-De’s Group:LUO Shi-DeWANG Yi-Fen JU Peng

LUO Xiao-Dong’s Group:LUO Xiao-DongDU Zhi-ZhiCAI Xiang-Hai

QIU Ming-Hua’s Group:QIU Ming-HuaLI Zhong-RongZHOU LinHE Chun-LinCHEN Jian-ChaoZHANG Xian-Min

SHEN Yue-Mao’s Group:SHEN Yue-MaoZENG YingZHAO Pei-JiXIE YongMA Juan

SUN Han-Dong’s Group:SUN Han-DongXIAO Wei-LieLI Rong-TaoPU Jian-Xin

TAN Ning-Hua's Group:TAN Ning-HuaXIONG JiangZHANG Yu-MeiJIA Rui-Rui (until July 2007)HAN Hong-JinJI Chang-JiuZHU Mei-juJIANG Li-Hua (until Sep. 2007)Pan Xu-Lin

ZHANG Ying-Jun’s Group:ZHANG Ying-JunCHEN Ke-KeWANG DongZHU Hong-TaoYANG Chong-Ren(until March 2007)ZHANG Xiang-LanXU Min

ZHAO Qin-Shi’s Group:ZHAO Qin-ShiCHENG Xiao

WANG YunZHOU Lv-LiuWANG Dan-DanGUO Jing-QiLI Li-LingLIU Yun-LongLANG RongZHUANG Hui-FuTANG Gui-HuaZHAO Yan-LIWANG Xue-Qin

Ph.D. Students(11):HAN Chun-YanLI Ya-LiHU Guang-WanTANG An-JunZHANG Xue-MeiMA XingLI Zhuo-QingYU Hai-YingLONG BoYANG Chun-YanLIU Wen-Jiang

State Key Laboratory of Phytochemistry and Plant Resources in West China

Director:LIU Ji-Kai (Concurrent Post)

Deputy Directors:TAN Ning-HuaZHAO Qin-Shi

Phytochemistry Analysis and Testing CenterLIANG Hui-Ling (Executive chief)HE Yi-NengWU YuYU ZhenQU Yan

Secretary:LIN Xian LI Lin Innovation Base Consultant:ZHOU JunLIU Yu-Qing(Secretary)

CHEN Ji-Jun’s Group:CHEN Ji-JunLIU Xi-KuiZHAO You-XingZHANG Xue-MeiMA Yun-BaoJIANG Zhi-YongLUO Jie

CHENG Yong-Xian’s Group:CHENG Yong-XianLV Qing

HAO Xiao-Jiang’s Group:HAO Xiao-JiangHE Hong-PingLI Shun-Ping

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43Annual Report 2007

XU GangPENG Li-YanZHAO YuLUO Cheng(Overseas senior visiting scientist)

ZHU Hua-Jie’s Group:ZHU Hua-JieREN JieJIANG Si-Ping(Western Light visiting scholar)

LI Yan’s Group:LI YanWANG Yuan-Yuan

Other Members:ZHOU Qian-LanLIU Xiao-BingTAO Shi-CongXU Gui-LunYU Dao-YouWANG BoHONG XinLI Sheng-HongLI Hai-ZhouHU Jiang-Miao

Master’s Students (62):ZHANG Nen-LinWANG En-Jun LIU Wen-FengLIU Jian-JunGENG Chang-AnWANG Hai-BoMEI Ren-QiangZHAO JunTONG Xiao-GangGAO SuoLIU Xiang-DongZHANG YuCHEN JiaZHU FengLI Shi-FeiJIANG Meng-YuanZHOU Zhong-YuZHANG LinFANG Sheng-TaoFENG TaoLIU Ya-PingZHANG Rong-TingDU Guo-ShunNIAN Yin CHENG Bao-HuiYAN Yu-XinZHANG Xu-DongWEI Guo-ZhuLI Jun-LinFAN Jun-TingYAN HeGAO Da-FangLIAO Peng-YingLIU QiangTIAN Li-WenZHANG Peng-TaoHE JunGUO NaLI Ming-MingWANG Zi-Juan

CHEN Gui-JvDENG Ya-NiCAO Jin-XinHUANG Sheng-ZhuoWANG Wei-Qing ZHANG Xiang-YunYANG Ting-QuanWANG Hong-LinZENG Lin-HongLIU Lin-LiDENG XuWANG Peng-ChengXIAO XiaoLI Da-ShanHAN JingNING JingSONG Wei-WuNIU YunWANG Cui-FangGAO JuanCHEN Jin-XiongZHOU Lei

Ph.D. Students (52):CHENG Bi ZHANG QuanLIU Ji-FengWANG Hao-XinGAO Zhu-LinFANG XinTAN Cheng-JianMA Xiao-XiaTAN Qin-GangZHANG ZhenZHANG QiangFANG Li-ZhenYANG Wan-QiuYI Ping GENG Zhao-LiangLI Chun-ShunKANG Qian-JinYUAN LinLEI ChunLIU Jing-PingZHAO YongYANG Li-BinGAO Xue-MeiTU LinLI Xiao-NianLUO XiaoCHEN Xuan-QinHE FeiTANG JunHUANG Huo-QiangXU Jun-JVNIU Dong-LingWANG WeiLIAO Tou-GenJIANG Jv-XingKONG Ling-ChuanLU LuYANG Xiao-Long LI Liang-BoXU Wen-YanCHENG Zhong-QuanPAN Zheng-HongYAN Xiao-Hui

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44 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

GU Zhi-Jian’s Group:GU Zhi-Jian

HU Hong’s Group:HU HongZHANG Shi-BaoYAN NingWANG HuaLI Shu-YunLUO Gui-FENHUANG Jia-LinGUO Rui-XianHU Shi-JunNI Zhen

LI Wei-Qi ’s Group:LI Wei-QiTIAN BoWANG RongZHANG Fu-JuanLI He

SUN Wei-Bang’s Group:SUN Wei-BangZHOU Yuan

Master’s Students(28):JI LiZHAO Xing-FengTANG LingWANG XiangZHANG LeZHAN Qing-QingWANG Jin-FengZHAO Yu-JuanJI HuiREN Yong-QuanHU Xiao-JianXUE Rui-JuanYU Xiao-QinLEI MingPI Qiu-XiaZHENG Guo-WeiJIA Yan-XiaWANG Rui-PingLI Li-XiaCAI Yan-FeiAI JuanPAN RuiYU Jiao-JunMOU Zong-MinYANG HuiLI YanYU Xiao-MeiYANG Li-Hua

Ph.D. Students(13):YANG Yao-WenLI Ai-RongMA Hong GUAN Zhi-JieLIU Li-QinJIANG NanWU Jiang-ChongCHANG WeiYU Bu-ZhuZHENG Yan-Ling

LIU RongHU JiangSHEN YongYANG Jian-HongZHANG Hai-BoHE Wen-JunSUN YunWANG KouZUO Ai-Xue

Botanic GardenDirector:LI De-Zhu (Concurrent Post)

Executive Director:SUN Wei-Bang

Deputy Director:LI Wei-Qi

Horticulture Center (supporting system):SUN Wei-Bang (executive chief)XIE Li-ShanWANG Zhong-LangFENG Bao-JunKONG Fan-CaiYIN QinYU Hong-YuanYUAN Hui-KunXU KunLI Xing-GuiMAO He-LiZHANG Cheng-MinPI Wen-LinLV Yuan-LinZHU ZhouSHEN Yun-GuangXIE JianKONG Xian-FengKUANG JianWANG Shi-QiongZHANG TaoLU Ren-FuLI Cong-RenLI Yue-MingCHEN YuLI YunZHANG Yun-ChunLI Ping-Hua

GONG Xun’s Group:GONG XunZHANG Zhao-YangPAN Yue-ZhiYANG Zhi-YunZHANG Guo-Li

GUAN Kai-Yun’s Group:GUAN Kai-YunLI Hong-ZheLI Jing-XiuLU Yuan-XueHE Zhong-JunYANG Yong-HongCHEN JingLI Ai-Rong

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45Annual Report 2007

WANG Kun-ShengZHAO Feng-LanDONG Hai-JunZHOU Jia-XingFAN Xi-KaiFU Bao-ChongHU Zhao-ChangHUANG LiJIAO Yun-TingLI Hai-YanLI Ping-LanLI Ping-YiLI Ying-HuiQIN Guo-FuWANG Ya-LinYANG Yong-RuiYE Shi-Qing (until November 2007)ZHONG Shun-RongBAI Bo

Botanical Society of YunnanExclusive personnel:ZHAO Jun-FenLIN Qin

Center for Mountain Ecosystem StudiesDirector:XU Jian-Chu

Members:CHEN Hua-FangYAN MeiZHANG Yi-FeiSU Yu-FangTimm TennigkeitLI Zheng-LiHE JunHU Xin-PingCHEN DongMU Zhi-Lin

KIB Academic Committee and Academic Committees of State and CAS Key Laboratories KIB Academic Committee Chairman:SUN Han-Dong

Members:CHEN Jin(Xishuangbanna Tropical Botanical Garden, CAS)GONG XunGUAN Kai-YunHAO Xiao-JiangHU HongLI De-ZhuLI Wei-QiLIU Ji-KaiLIU Pei-GuiLONG Chun-LinPENG HuaQIU Ming-HuaSUN HangTAN Ning-HuaXU Jian-ChuYANG Yong-PingYANG Zhu-LiangZHANG Chang-QinZHANG Ke-Qin(Yunnan University)

WANG Zi-JuanYang Jing CHEN Hong-Ying

Germplasm Bank of Wild Species in Southwest ChinaAdministration Office:LI De-ZhuGAN Fan-YuanLONG Chun-LinYANG Xiang-YunZHANG Ying-JueYANG Zhi-Hua(until May 2007)HE WeiZOU Jun-WuSHI Zhang-Fu(until March 2007)

Supporting System:YANG Xiang-Yun(executive chief)ZHANG Ting DU YanLI Ai-HuaGUO Yun-Gang

GAO Li-Zhi’s Group:GAO Li-ZhiPENG Sheng JIAO Jun-YingYANG Li-LiXU Ping-ZhenZHAO You-Jie

YI Ting-Shuang’s Group:YI Ting-ShuangYANG Yang

Other Members:

GUO Zhen-HuaLI Hong-Tao

Master’s Students(4):LIU YangMENG Jing HU NaFAN Ya-Yu Ph.D. Student(1):LIN Li-Zhen

Institute of Tibetan Plateau Research at Kunming, CASDirector:YANG Yong-Ping (Concurrent Post)

Members:HAN XiDUAN Yuan-WenCHEN Jia-HuiMENG YingHU Xiang-Yang

Logistics CenterManager:YI Yong-Sheng

Members:SONG Wei-KuiCAi Ming

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46 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

ZHANG Ya-Ping(Kunming Institute of Zoology, CAS)ZHANG Zhuang-Xin(CAS Kunming Branch)ZHOU Zhe-KunZHU Hua-JieZHU You-Yong(Yunnan Agricultural University)

Academic Committee for State Key Laboratory of Phytochemistry and Plant Resources in West China

Chairman of Academic Committee: HAO Xiao-JiangVice Chairman of Academic Committee:SUN Han-DongCHEN Xiao-Ya(Shanghai Institutes for Biological Sciences, CAS)

Committee:PEI Gang (Shanghai Institutes for Biological Sciences, CAS)DENG Zi-Xin (Shanghai Jiaotong University)TAN Ren-Xiang (Nanjing University)TU Yong-Qiang (Lanzhou University)ZHANG Hong-Bin (Yunnan University)DU Guan-Hua (Institute of Materia Medica, Chinese Academy of Medical Sciences)Ding Jian (Shanghai Institute of Materia Medica, CAS)JIANG Hua-Liang (Shanghai Institute of Materia Medica, CAS)MA Da-Wei (The Shanghai Institute of Organic Chemistry, CAS)LI De-ZhuLIU Ji-KaiTAN Ning-Hua

Advisors to the Academic Committee: ZHOU JunYU De-Quan (Institute of Materia Medica, Chinese Academy of Medical Sciences)YAO Xin-Sheng (Shenyang Pharmaceutical University)HONG De-Yuang (Institute of Botany, CAS)LIN Guo-Qiang (The Shanghai Institute of Organic Chemistry, CAS)

Academic Committee for CAS Key Laboratory of Biodiversity and BiogeographyChairman:CHEN Yi-Yu (National Natural Science Foundation of China)

Vice Chairman:LI De-Zhu

Members:ZHANG Ya-Ping (Kunming Institute of Zoology, CAS)GU Hong-Ya (College of Life Sciences of Peking University)SHI Su-Hua (Zhongshan University)GE Song (Institute of Botany, CAS)ZHANG Ke-Qin (Yunnan University)SUN Ge (Jilin University)YANG Yu-Ming (Southwest Forestry College)Li Wen-Hua (Institute of Geography and Natural Resources, CAS)SUN HangZHOU Zhe-KunPENG HuaCHEN Jin (Xishuangbanna Tropical Botanical Garden, CAS)WEN Jun (Smithsonian Institution)

Honorary Posts:Honorary Chair of the Academic Committee of CAS Key Laboratory of Biodiversity and Biogeography:Peter Raven (Missouri Botanical Garden, Foreign Member of CAS)

Honorary Professors:Stephen Blackmore (Royal Botanic Garden Edinburgh)Nam-Hai Chua (Rockefeller University)Antony Galsworthy (former British ambassador to P. R. China)Jun Wen (Smithsonian Institution)

Honorary Director of Horticulture: David Paterson (Royal Botanic Garden Edinburgh)

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47Annual Report 2007

1. Cai, X. H., Z. Z. Du, et al. (2007).'Tirucallane triterpenoid Saponins from Munronia delavayi Franch.'Helvetica Chimica Acta 90(10):1980-1986.

2. Cai, X. H., Z. Z. Du, et al. (2007). 'Unique monoterpenoid indole alkaloids from Alstonia scholaris .' Organic Letters 9(9): 1817-1820.

3. Cai, X. H. and X. D. Luo (2007). 'Alkaloids from Stemona mairei .' Planta Medica 73(2): 170-173.

4. Cai, X. H. and X. D. Luo (2007). 'A new tetranortriterpenoid from Munronia delavayi .' Chinese Journal of Chemistry 25(7): 986-988.

5. Chen, G., W. B. Sun, et al. (2007). 'Karyomorphology of the endangered Trigonobalanus doichangensis (A. Camus) Forman (Fagaceae) and its taxonomic and biogeographical implications.' Botanical Journal of the Linnean Society 154(3): 321-330.

6. Chen, G., W. B. Sun, et al. (2007). 'Ploidy variation in Buddleja L. (Buddlejaceae) in the Sino-Himalayan region and its biogeographical implications.' Botanical Journal of the Linnean Society 154(3): 305-312.

7. Chen, J. C., Z. Q. Zhang, et al. (2007). 'Chemical constituents from the tubers of Hemsleya delavayi .' Acta Chimica Sinica 65(16): 1679-1684.

8. Chen, W. H., Y. M. Shui, et al. (2007). 'Additional notes on Melastomataceae of China.' Acta Phytotaxonomica Sinica 45(4): 587-592.

9. Cheng, P., Y. B. Ma, et al. (2007). 'Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida.' Bioorganic & Medicinal Chemistry Letters 17(19): 5316-5320.

10. Chu, H. B., N. H. Tan, et al. (2007). 'Chemical constituents from Pedicularis rex CB Clarke.' Zeitschrift Fur Naturforschung Section B-a Journal of Chemical Sciences 62(11): 1465-1470.

11. Dao, Z. L., S. T. Chen, et al. (2007). 'Typhonium baoshanense Z. L. Dao & H. Li, a new species of Araceae from western Yunnan, China.' Acta Phytotaxonomica Sinica 45(2): 234-238.

12. Deng, C., L., Q.- G., Ren, Y., et al. (2007). 'A Comprehensive Theoretical Study on the Hydrolysis of Carbonyl Sulfide in the Neutral Water.' Journal of Computer Chemistry. 29:467.

13. Deng, Y. F. (2007). 'Validation of the name Strobilanthes sarcorrhiza (Acanthaceae).' Novon 17(2): 154-155.

14. Di, Y. T., H. P. He, et al. (2007). 'Trijugin-type limonoids from the leaves of Cipadessa cinerascens.' Journal of Natural Products 70(8): 1352-1355.

APPENDIX 2: LIST OF PUBLICATIONS

Articles cited by SCI with KIB Staff as first Author

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15. Di, Y. T., H. P. He, et al. (2007). 'Isolation, X-ray crystallography, and computational studies of calydaphninone, a new alkaloid from Daphniphyllum calycillum.' Organic Letters 9(7): 1355-1358.

16. Fang, L. Q., Y. Z. Pan, et al. (2007). 'A karyomorphological study in the monotypic genus Lamiophlomis and five species in Phlomis (Lamiaceae).' Acta Phytotaxonomica Sinica 45(5): 627-632.

17. Gao, L. M., M. Möller, et al. (2007). 'High variation and strong phylogeographic pattern among cpDNA haplotypes in Taxus wallichiana (Taxaceae) in China and North Vietnam.' Molecular Ecology 16(22): 4684-4698.

18. Gao, S., H. Y. Liu, et al. (2007). 'Lathyranone A: A diterpenoid possessing an unprecedented skeleton from Euphorbia lathyris .' Organic Letters 9(17): 3453-3455.

19. Gu, Q., R. R. Wang, et al. (2007). 'A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis .' Planta Medica 73(3): 279-282.

20. He, J., H. Wang, et al. (2007). 'Genetic diversity of Paris polyphylla var. yunnanensis , a traditional chinese medicinal herb, detected by ISSR markers.' Planta Medica 73(12): 1316-1321.

21. Hu G.W., C.L., Long, et al. (2007). 'Utricularia mangshanensis (Lentibulariaceae), a new species from Hunan, China.' Annales Botanici Fennici 44 (5): 389-392.

22. Hua, Y., C. X. Chen, et al. (2007). 'Two new xanthones from Polygala crotalarioides.' Journal of Asian Natural Products Research 9(3): 273-275.

23. Hua, Y., H. Y. Liu, et al. (2007). 'New eudesmane and cadalane sesquiterpenes from Parepigynum funingense.' Zeitschrift Fur Naturforschung Section B-a Journal of Chemical Sciences 62(2): 272-274.

24. Hua, Y., J. Ren, et al. (2007). 'Determinations of the configuration of C-20 in derivatives of adynerin using DFT/HF methods.' Chemical Research in Chinese Universities 23(5): 592-597.

25. Hua, Y., J. Zhou, et al. (2007). 'A new eudesmane sesquiterpene glycoside from Parepigynum funingense.' Chinese Chemical Letters 18(1): 73-75.

26. Huang, J. and C. L. Long (2007). 'Coptis teeta-based agroforestry system and its conservation potential: A case study from northwest Yunnan.' Ambio 36(4): 343-349.

27. Huang, S. X., R. T. Li, et al. (2007). 'Isolation and characterization of biogenetically related highly oxygenated nortriterpenoids from Schisandra chinensis .' Organic Letters 9(11): 2079-2082.

28. Huang, S. X., J. X. Pu, et al. (2007). 'ent-Abietane diterpenoids from Isodon rubescens var. rubescens.' Phytochemistry 68(5): 616-622.

29. Huang, S. X., J. Yang, et al. (2007). 'Structural characterization of schintrilactone, a new class of nortriterpenoids from Schisandra chinensis .' Organic Letters 9(21): 4175-4178.

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30. Huang, S. X., L. B. Yang, et al. (2007). 'Wuweizidilactones A-F: Novel highly oxygenated nortriterpenoids with unusual skeletons isolated from Schisandra chinensis .' Chemistry-a European Journal 13(17): 4816-4822.

31. Huang, S. X., Y. Zhou, et al. (2007). 'Alboatisins A-C, ent-atisene diterpenoids from Isodon albopilosus.' Journal of Natural Products 70(6): 1053-1055.

32. Huang, H. Q., X. L. Pan, et al. (2007). '3D-QSAR study of sulfonamide inhibitors of human carbonic anhydrase II.' European Journal of Medicinal Chemistry 42(3): 365-372.

33. Ji, Y. H., Z. K. ZHOU, et al. (2007). 'Four new synonyms in the genus Paris (Trilliaceae).' Acta Phytotaxonomica Sinica. 45(3):388-390.

34. Jia, A. Q., N. H. Tan, et al. (2007). 'New cyclopeptides in Arenaria oreophila (Caryophyllaceae).' Journal of Asian Natural Products Research 9(6): 569-574.

35. Jia, A. Q., N. H. Tan, et al. (2007). 'Cyclopeptides from Sagina japonica (Caryophyllaceae).' Chemistry & Biodiversity 4(2): 241-247.

36. Jiang, Z. Y., X. M. Zhang, et al. (2007). 'Two new sesquiterpenes from Alisma orientalis .' Chemical & Pharmaceutical Bulletin 55(6): 905-907.

37. Jin, X. H., T. Zhang, et al. (2007). 'Cytological studies on the genus Holcoglossum (Orchidaceae).' Botanical Journal of the Linnean Society 154(2): 283-288.

38. Ju, P., Y. F. Wang, et al. (2007). 'A new ellagitannin from Cleidion bracteosum.' Chinese Chemical Letters 18(3): 291-292.

39. Kong, N. C., H. P. He, et al. (2007). 'Two new iridoid alkaloids, daphmacropodosidines A and B, from Daphniphyllum macropodum.' Helvetica Chimica Acta 90(5): 972-976.

40. Kong, N. C., H. P. He, et al. (2007). 'Daphnimacropodines A-D, alkaloids from Daphniphyllum macropodum.' Journal of Natural Products 70(8): 1348-1351.

41. Lei, C., S. X. Huang, et al. (2007). 'Four new schisanartane-type nortriterpenoids from Schisandra propinqua var. propinqua .' Helvetica Chimica Acta 90(7): 1399-1405.

42. Lei C., S. X. Huang, et al. (2007). 'Lignans from Schisandra propinqua var. propinqua .' Chemical & Pharmaceutical Bulletin 55 (8): 1281-1283.

43. Li, A. R. and K. Y. Guan (2007). 'Mycorrhizal and dark septate endophytic fungi of Pedicularis species from northwest of Yunnan Province, China.' Mycorrhiza 17(2): 103-109.

44. Li, C. S., Y. T. Di, et al. (2007). 'Daphlongeranines A and B, two novel alkaloids possessing unprecedented skeletons from Daphniphyllum longeracemosum.' Organic Letters 9(13): 2509-2512.

45. Li, C. S., H. P. He, et al. (2007). 'Daphlongeramine A, novel Daphniphyllum alkaloid from Daphniphyllum longeracemosum.' Tetrahedron Letters 48(15): 2737-2740.

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46. Li, H. M. and Z. K. Zhou (2007). 'Fossil nothofagaceous leaves from the Eocene of western Antarctica and their bearing on the origin, dispersal and systematics of Nothofagus .' Science in China Series D-Earth Sciences 50(10): 1525-1535.

47. Li, L. C., J. Ren, et al. (2007). 'A novel direct conversion of primary amides to their corresponding methyl esters.' European Journal of Organic Chemistry(6): 1026-1030.

48. Li, L. M., G. Y. Li, et al. (2007). 'Sculponins A-C, three new 6,7-seco-ent-kauranoids from Isodon sculponeatus.' Tetrahedron Letters 48(52): 9100-9103.

49. Li, L. M., Z. Y. Weng, et al. (2007). 'Cytotoxic ent-kauranoids from the Medicinal Plant Isodon xerophilus .' Journal of Natural Products 70(8): 1295-1301.

50. Li, N., K. J. Wang, et al. (2007). 'Phenolic compounds from the rhizomes of Gastrodia elata .' Journal of Asian Natural Products Research 9(4): 373-377.

51. Li, W. H., X. M. Zhang, et al. (2007). 'A new anti-HIV lupane acid from Gleditsia sinensis Lam.' Journal of Asian Natural Products Research 9(6): 551-555.

52. Li, X., J. X. Pu, et al. (2007). 'Three new ent-kauranoids from Isodon phyllostachys .' Heterocycles 71(11): 2441-2447.

53. Li, X. L., L. M. Yang, et al. (2007). 'Tetranorclerodanes and clerodane-type diterpene glycosides from Dicranopteris dichotoma.' Journal of Natural Products 70(2): 265-268.

54. Li, X. X. and Z. K. Zhou (2007). 'The higher-level phylogeny of monocots based on matK, rbcL and 18S rDNA sequences.' Acta Phytotaxonomica Sinica 45(2): 113-133.

55. Li, Y. C. (2007). 'Two noteworthy boletes from China.' Mycotaxon 101: 223-228.

56. Li, Y. M., L. H. Wang, et al. (2007). 'Seco-pregnane steroids target the subgenomic RNA of alphavirus-like RNA viruses.' Proceedings of the National Academy of Sciences of the United States of America 104(19): 8083-8088.

57. Liang, H. X., F. K. Bao, et al. (2007). 'Antibacterial thymol derivatives isolated from Centipeda minima.' Molecules 12(8): 1606-1613.

58. Liang, H. X., F. K. Bao, et al. (2007). 'Two new antibacterial sesquiterpenoids from Centipeda minima.' Chemistry & Biodiversity 4(12): 2810-2816.

59. Liu, D. Z., F. Wang, et al. (2007). 'A new cadinane sesquiterpene with significant anti-HIV-1 activity from the cultures of the basidiomycete Tyromyces chioneus.' Journal of Antibiotics 60(5): 332-334.

60. Liu D.Z., F. Wang, et al. (2007). 'Sesquiterpenes from cultures of the basidiomycete Conocybe siliginea.' Journal of Natural Products 70(9): 1503-1506.

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61. Liu, H. Y., S. Gao, et al. (2007). 'A novel atisane diterpenoid from Spiraea japonica var. acuta.' Helvetica Chimica Acta 90(7): 1386-1390.

62. Liu, P. G. and J. Chen (2007). 'Tuber latisporum sp. nov. and related taxa, based on morphology and DNA sequence data.' Mycologia 99(3):465-481.

63. Liu, J. F., Z. Y. Jiang, et al. (2007). 'Isatisine a, a novel alkaloid with an unprecedented skeleton from leaves of Isatis indigotica.' Organic Letters 9(21): 4127-4129.

64. Lu, J. M., D. S. Barrington, et al. (2007). 'Molecular phylogeny of the polystichoid ferns in Asia based on rbcL sequences.' Systematic Botany 32(1): 26-33.

65. Lu, L., H. Wang, et al. (2007). 'Pollen morphology of the tribe Rhinantheae (Orobanchaceae) and its systematic significances.' Plant Systematics and Evolution 268(1-4): 177-198.

66. Ma, C. L., R. K. Moseley, et al. (2007). 'Plant diversity and priority conservation areas of Northwestern Yunnan, China.' Biodiversity and Conservation 16(3): 757-774.

67. Ma, J., P. J. Zhao, et al. (2007). 'New amide N-glycosides of ansamitocins identified from Actinosynnema pretiosum.' Archives of Pharmacal Research 30(6): 670-673.

68. Ma, X. X., F. T. Jiang, et al. (2007). 'New pregnane glycosides from the roots of Cynanchum otophyllum.' Steroids 72(11-12): 778-786.

69. Melick, D., Yang, X. F., et al. (2007). 'Seeing the wood for the trees: how conservation policies can place greater pressure on village forests in southwest China.' Biodiversity and Conservation 16(6): 1959-1971.

70. Mu, S. Z., C. S. Li, et al. (2007). 'Daphnipaxianines A-D, alkaloids from Daphniphyllum paxianum.' Journal of Natural Products 70(10): 1628-1631.

71. Mu, S. Z., X. W. Yang, et al. (2007). 'Secophnane-type alkaloids from Daphniphyllum oldhami.' Chemistry & Biodiversity 4(2): 129-138.

72. Nie Z. L., J. Wen, et al. (2007). 'Phylogeny and biogeography of Sassafras (Lauraceae) disjunct between eastern Asian and eastern North America.' Plant Systematics and Evolution 267:191-203.

73. Niu D. L., L. S Wang, et al. (2007). 'A chemotaxonomic study of Lethariella zahlbruckneri and L. smithii (lichenized Ascomycota, Parmeliaceae) from Hengduanshan Mountains.' Lichenologist 39(6): 549-553.

74. Pu, J. X., S. X. Huang, et al. (2007). 'Isolation and structure elucidation of kadlongilactones C-F from Kadsura longipedunculata by NMR spectroscopy and DFT computational methods.' Journal of Natural Products 70(11): 1706-1711.

75. Pu, J. X., W. L. Xiao, et al. (2007). 'Three new compounds from Kadsura longipedunculata. ' Helvetica Chimica Acta 90(4): 723-729.

76. Qiao, Y., X. M. Zhang, et al. (2007). 'Two novel lanostane triterpenoids from Ganoderma sinense.' Molecules 12(8): 2038-2046.

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52 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

77. Gu Q., Y. B. Ma, et al. (2007). 'One new flavanoid and Anti-HIV active constituents from Boussingaultia gracilis Miers var. pseudobaselloides Bailey.' Chemical Journal of Chinese Universities-Chinese 28(8): 1508-1511.

78. Ren, Y. L., Q. R. Tang, et al. (2007). 'Two new tetranortriterpenoids from Cipadessa cinerascens.' Helvetica Chimica Acta 90(4): 764-768.

79. Shao, H. J., C. J. Wang, et al. (2007). 'Pubescenone, a new marasmane sesquiterpenoid from the mushroom Lactarius pubescens.' Heterocycles 71(5): 1135-1139.

80. Shen Y. G., Z. L. Wang, K. Y. Guan.(2007). 'Karyotypes of thirteen species of Iris L. from China' Acta Phytotaxonomica Sinica 45 (5): 601-618.

81. Shui, Y. M. (2007). 'Begonia tetralobata (Begoniaceae), a new species from China.' Annales Botanici Fennici 44(1): 76-79.

82. Song, W. Y., Y. B. Ma, et al. (2007). 'Two new compounds and anti-HIV active constituents from Illicium verum.' Planta Medica 73(4): 372-375.

83. Song, Y. L., Y. H. Wang, et al. (2007). 'Two new triterpenoids from Photinia serrulata.' Molecules 12(12): 2599-2604.

84. Sun, L. R., C. Qing, et al. (2007). 'Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells.' Beilstein Journal of Organic Chemistry 3: 6.

85. Sun, L. R., J. Yan, et al. (2007). 'Cimicifine A: A novel triterpene alkaloid from the rhizomes of Cimicifuga foetida.' Helvetica Chimica Acta 90(7): 1313-1318.

86. Sun, W. B., C. Y. Han, et al. (2007). 'Genetic diversity of the rare Asian plant, Trigonobalanus doichangensis (Fagaceae).' Australian Journal of Botany 55(1): 10-17.

87.Sun, W. B., Y. Zhou,et al.(2007).'Chinese Magnolias- it's mostly as bad as we thought'. Oryx 41(4):427-428.

88. Wang, D., M. Xu, et al. (2007). 'Biotransformation of gentiopicroside by asexual mycelia of Cordyceps sinensis .' Bioorganic & Medicinal Chemistry Letters 17(11): 3195-3197.

89. Wang, F., Z. J. Dong, et al. (2007). 'Benzopyran-4-one derivatives from the fungus Ganoderma applanatum.' Zeitschrift Fur Naturforschung Section B-a Journal of Chemical Sciences 62(10): 1329-1332.

90. Wang, H. X., T. Yang, et al. (2007). 'Expression analysis of the gastrodianin gene ga4B in an achlorophyllous plant Gastrodia elata Bl.' Plant Cell Reports 26(3): 253-259.

91. Wang, K. J., C. R. Yang, et al. (2007). 'Phenolic antioxidants from Chinese toon (fresh young leaves and shoots of Toona sinensis).' Food Chemistry 101(1): 365-371.

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92. Wang, L. Q., J. H. Wang, et al. (2007). 'Three new C-21 steroidal glycosides from the roots of Cynanchum inamoenum.' Chinese Chemical Letters 18(10): 1235-1238.

93. Wang, M. Z., X. H. Cai, et al. (2007). 'A novel norditerpene from Eupatorium adenophorum.' Zeitschrift Fur Naturforschung Section B-a Journal of Chemical Sciences 62(4): 577-579.

94. Wang, Q., S. D. Luo, et al. (2007). 'Two novel nortriterpenoids from Gomphostemma parviflorum .' Helvetica Chimica Acta 90(7): 1360-1365.

95. Wang, X. H. (2007). 'Type studies of Lactarius species published from China.' Mycologia 99(2): 253-268.

96. Wang Y. F., X. Y. Wang, et al. (2007). 'Three new sesquiterpenoids from the aerial parts of Homalomena occulta .' Chemistry & Biodiversity 4(5):925-931.

97. Wang, Y. H., S. Gao, et al. (2007). 'Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea .' Organic Letters 9(25): 5279-5281.

98. Wang, Y. H., J. G. Tang, et al. (2007). 'Flazinamide, a novel beta-carboline compound with anti-HIV actions.' Biochemical and Biophysical Research Communications 355(4): 1091-1095.

99. Wang, Y. H., Z. K. Zhang, et al. (2007). 'Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase.' Journal of Natural Products 70(9): 1458-1461.

100. Wang, Y. H., Z. K. Zhang, et al. (2007). 'Stilbene C-glucosides from Cissus repens.' Journal of Asian Natural Products Research 9(7): 631-636.

101. Wei, Z. D., Y. M. Shui, et al. (2007). 'Begonia coelocentroides Y. M. Shui & Z. D. Wei, a new species of Begoniaceae from Yunnan, China.' Acta Phytotaxonomica Sinica 45(1): 86-89.

102. Weng Z. Y., S. X. Huang, et al. (2007). 'Isolation of Two Bioactive ent-Kauranoids from the Leaves of Isodon xerophilus .' Journal of Agriculture and Food Chemistry. 55: 6039-6043.

103. Wu, Y. R., Y. B. Ma, et al. (2007). 'Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola .' Planta Medica 73(8): 787-791.

104. Wu, Y. R., Y. X. Zhao, et al. (2007). 'Isoquinoline alkaloids from Corydalis teliensis .' Z. Naturforschung 62b: 1199-1202.

105. Wu, Z. Y., J. X. Wang, et al. (2007). 'Huma should be Linum usitatissimum, not Sesamum indicum - With special reference to the source of confusion of names for traditional Chinese medicine and the written time and author of Shen Nung Pen Ts'ao Ching.' Acta Phytotaxonomica Sinica 45(4): 458-472.

106. Xiao, H. T., X. Y. Hao, et al. (2007). 'Bisabolane-type sesquiterpenoids from the rhizomes of Glochidion coccineum.' Helvetica Chimica Acta 90(1): 164-170.

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54 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

107. Xiao, W. L., S. H. Li, et al. (2007). 'Two new coumarin glucosides from the roots of Angelica apaensis and their anti-platelet aggregation activity.' Archives of Pharmacal Research 30(7): 799-802.

108. Xiao, W. L., X. L. Li, et al. (2007). 'Triterpenoids from Schisandra rubriflora .' Journal of Natural Products 70(6): 1056-1059.

109. Xiao, W. L., J. X. Pu, et al. (2007). 'Isolation and structure elucidation of nortriterpenoids from Schisandra rubriflora .' Helvetica Chimica Acta 90(8): 1505-1513.

110. Xiao, W. L., L. M. Yang, et al. (2007). 'Sphenalactones A-D, a new class of highly oxygenated trinortriterpenoids from Schisandra sphenanthera.' Tetrahedron Letters 48(31): 5543-5546.

111. Xu, F. Q., H. M. Zhong, et al. (2007). 'Steroidal saponins from Lysimachia paridiformis. ' Journal of Asian Natural Products Research 9(6): 493-497.

112. Xu, G., A. J. Hou, et al. (2007). 'Przewalskin B, a novel diterpenoid with an unprecedented skeleton from Salvia przewalskii Maxim.' Organic Letters 9(2): 291-293.

113. Xu, J. C. and D. R. Melick (2007). 'Rethinking the effectiveness of public protected areas in southwestern China.' Conservation Biology 21(2): 318-328.

114. Xu, J. P., H. Guo, et al. (2007). 'Single nucleotide polymorphisms in the ectomycorrhizal mushroom Tricholoma matsutake.' Microbiology-SGM 153: 2002-2012.

115. Xu, M., Z. J. Zha, et al. (2007). 'Phenolic antioxidants from the whole plant of Phyllanthus urinaria .' Chemistry & Biodiversity 4(9): 2246-2252.

116. Xue, C. Y., T. N. Ho, et al. (2007). 'Embryology of Swertia (Gentianaceae) relative to taxonomy.' Botanical Journal of the Linnean Society 155(3): 383-400.

117. Xue, C. Y. and D. Z. Li (2007). 'Molecular identification of the traditional Tibetan medicinal plant Gentianopsis paludosa (Gentianaceae) using diagnostic PCR and PCR-RFLP based on nrDNA ITS regions.' Planta Medica 73(9): 1011-1012.

118. Xue, C. Y., H. Wang, et al. (2007). 'Female gametophyte and seed development in Musella lasiocarpa (Musaceae), a monotypic genus endemic to Southwestern China.' Canadian Journal of Botany-Revue Canadienne De Botanique 85(10): 964-975.

119. Yang, H. Q. and D. Z. Li (2007). 'Two new combinations in Cephalostachyum (Poaceae: Bambusoideae).' Annales Botanici Fennici 44(2): 155-156.

120. Yang, H. Q., S. Peng, et al. (2007). 'Generic delimitations of Schizostachyum and its allies (Gramineae: Bambusoideae) inferred from GBSSI and trnL-F sequence phylogenies.' Taxon 56(1): 45-54.

121. Yang, W. Q., X. D. Qin, et al. (2007). 'New phenyl-ethanediols from the culture broth of Boletus edulis .' Journal of Basic Microbiology 47(2): 191-193.

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122. Yang, X., S. G. Lu, et al. (2007). 'First report of chromosome numbers of the Carlemanniaceae (Lamiales).' Journal of Plant Research 120(6): 707-712.

123. Yang, X. L., K. L. Hsieh, et al. (2007). 'Guajadial: An unusual meroterpenoid from guava leaves Psidium guajava.' Organic Letters 9(24): 5135-5138.

124. Yang, X. W., J. S. Wang, et al. (2007). 'Bioactive Phenols from the leaves of Baccaurea ramiflora .' Planta Medica 73(13): 1415-1417.

125. Yang, X. W., J. S. Wang, et al. (2007). 'Tarennane and tarennone, two novel chalcone constituents from Tarenna attenuata.' Planta Medica 73(5): 496-498.

126. Yang, X. W., P. J. Zhao, et al. (2007). 'Mixed lignan-neolignans from Tarenna attenuata .' Journal of Natural Products 70(4): 521-525.

127. Yang, Z. L. (2007). 'Clitopilus amygdoliformis , a new species from tropical China.' Mycotaxon 100: 241-246.

128. Yang, Z. L. (2007). 'Type studies on Chamaeota species described from China.' Mycotaxon 100: 279-287.

129. Yu, F. Q., G. B. Xu, et al. (2007). 'A new and noteworthy species of Hygrophorus from Yunnan, China.' Mycotaxon 100: 169-175.

130. Yu, Y. F., Q. Lu, et al. (2007). 'Myricananone and myricananadiol: Two new cyclic 'Diarylheptanoids' from the roots of Myrica nana.' Helvetica Chimica Acta 90(9): 1691-1696.

131. Zhang, J. L., C. Q. Zhang, et al. (2007). 'Natural hybridization origin of Rhododendron agastum (Ericaceae) in Yunnan, China: inferred from morphological and molecular evidence.' Journal of Plant Research 120(3): 457-463.

132. Zhang, J. W., H. Sun, et al. (2007). 'Karyological studies on the Sino-Himalayan endemic Soroseris and two related genera of tribe Lactuceae (Asteraceae).' Botanical Journal of the Linnean Society 154(1): 79-87.

133. Zhang, M. D., W. H.Chen, et al. (2007). 'Miscellaneous notes on the tribe Gardenieae (Rubiaceae) from China and Vietnam.' Acta Phytotaxonomica Sinica 45(1): 90-93.

134. Zhang, S. B., H. Hu, et al. (2007). 'Flexible and reversible responses to different irradiance levels during photosynthetic acclimation of Cypripedium guttatum.' Journal of Plant Physiology 164(5): 611-620.

135. Zhang, S. B., Z. K. Zhou, et al. (2007). 'Gas exchange and resource utilization in two alpine oaks at different altitudes in the Hengduan Mountains.' Canadian Journal of Forest Research-Revue Canadienne De Recherche Forestiere 37(7): 1184-1193.

136. Zhang, Y., H. Sun., et al. (2007). 'Two new species of Wikstoroemia (Thymelaeaceae) from western Sichuan, China. ' Rhodora 109(940):448-455.

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56 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

1. Cheng, P., Z. Y. Jiang, et al. (2007). 'Synthesis and biological evaluation of N-acetyl-beta-aryl-1,2-didehydroethylamines as new HIV-1 RT inhibitors in vitro.' Bioorganic & Medicinal Chemistry Letters 17(16): 4476-4480.

2. Dillon, M. O., T. Tu, et al. (2007). 'Phylogeny of Nolana (Nolaneae, Solanoideae, Solanaceae) as inferred from granule-bound starch synthase I (GBSSI) sequences.' Taxon 56(4): 1000-1011.

Other Publications

137. Zhang, Y., H. P. He, et al. (2007). 'Paxiphyllines a and b, new alkaloids from Daphniphyllum paxianum.' Tetrahedron Letters 48(52): 9104-9107.

138. Zhang Y.H., D.E.Boufford, et al. (2007). 'Taxonomic note on Wikstroemia salicina (Thymelaeaceae).' Acta Phytotaxonomica Sinica 45(3):413-414.

139. Zhang, Y. M., N. H. Tan, et al. (2007). 'Triterpenoid saponins from Metadina trichotoma.' Zeitschrift Fur Naturforschung Section B-a Journal of Chemical Sciences 62(5): 745-748.

140. Zhang, Y. M., N. H. Tan, et al. (2007). 'Chamobtusin a, a novel skeleton diterpenoid alkaloid from Chamaecyparis obtusa cv. tetragon.' Organic Letters 9(22): 4579-4581.

141. Zhang, Z., G. M. Liu, et al. (2007). 'A new isoflavonolignan from Pueraria alopecuroides Craib.' Chinese Chemical Letters 18(3): 297-299.

142. Zhang, Z. Q., J. C. Chen, et al. (2007). 'Two new cholestane bisdesmosides from Reineckia carnea.' Helvetica Chimica Acta 90(3): 616-622.

143. Zhao P. J., H. X. Wang, et al. (2007). 'Secondary Metabolites from Endophytic Streptomyces sp. Lz531.' Chemistry and Biodiversity 4: 899-904.

144. Zhao, Q. S., Y. W. Cong (2007). 'Michael reaction acceptor molecules in chemical biology.' Progress in Chemistry 19(12): 1972-1976.

145. Zhao, Y. B., Y. M. Shen, et al. (2007). 'Antifungal agent and other constituents from Cynanchum otophyllum.' Natural Product Research 21(3): 203-210.

146. Zhou, Z. K., Q. S. Yang, et al. (2007). 'Fossils of Quercus sect. Heterobalanus can help explain the uplift of the Himalayas.' Chinese Science Bulletin 52(2): 238-247.

147. Zhu, H. J., J. Ren, et al. (2007). 'Matrix model to predict specific optical rotations of acyclic chiral molecules.' Tetrahedron 63(10): 2292-2314.

148. Zhu, W. M., Q. Zhao, et al. (2007). 'Sesquiterpenoids from Hedychium yunnanense and Porana discifera , and the structural revision of two sesquiterpenoids from Laggera pterodonta.' Journal of Asian Natural Products Research 9(3): 277-283.

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57Annual Report 2007

3. Dong, J. Y., Y. H. Zhu, et al. (2007). 'Nematicidal resorcylides from the aquatic fungus Caryospora callicarpa YMF1.01026.' Journal of Chemical Ecology 33(5): 1115-1126.

4. Jacques, F. M. B. and S. X. Guo (2007). 'Palaeoskapha sichuanensis gen. et sp nov (Menispermaceae) from the Eocene Relu Formation in western Sichuan, West China.' Acta Phytotaxonomica Sinica 45(4): 576-582.

5. Kang, W. Y., B. R. Mang, et al. (2007). 'Isolation and identification of a new triterpene from Neonauclea sessilifolia.' Chemical Journal of Chinese Universities-Chinese 28(11): 2096-2098.

6. Körner, C., M. Donoghue, et al. (2007). 'Creative use of mountain biodiversity databases: The Kazbegi research agenda of GMBA-DIVERSITAS.' Mountain Research and Development 27(3): 276-281.

7. Kuroda, C., K. Kiuchi, et al. (2007). 'Chemical and genetic diversity of Ligularia latihastata and Ligularia villosa in Yunnan Province of China.' Chemistry & Biodiversity 4(9): 2210-2217.

8. Li, H., T. Tanaka, et al. (2007). 'Rubusuaviins a-f, monomeric and oligomeric ellagitannins from Chinese sweet tea and their alpha-amylase inhibitory activity.' Chemical & Pharmaceutical Bulletin 55(9): 1325-1331.

9. Li, Y. M., Y. T. Jia, et al. (2007). 'Purification and characterization of a new ribosome inactivating protein from cinchonaglycoside C-treated tobacco leaves.' Journal of Integrative Plant Biology 49(9): 1327-1333.

10. Liden, M. and Z. Y. Su (2007). 'New species of Corydalis (Fumariaceae) from China II.' Novon 17(4): 479-496.

11. Liu, H. Y., S. J. Li, et al. (2007). 'Four new podocarpane-type trinorditerpenes from Aleurites moluccana.' Helvetica Chimica Acta 90(10): 2017-2023.

12. Lu, Y. B., N. C. Kong, et al. (2007). 'Paxdaphnine B: a 1,19-bisnor-daphniphyllum alkaloid.' Acta Crystallographica Section E-Structure Reports Online 63: O589-O591.

13. Luo, D. Q., Y. Gao, et al. (2007). 'Highly oxidized humulane Sesquiterpenes from the basidiomycete Lactarius mitissimus.' Journal of Antibiotics 60(2): 162-165.

14. Luo, D. Q., Y. Gao, et al. (2007). 'Two new highly oxidized humulane sesquiterpenes from the basidiomycete Lactarius mitissimus.' Helvetica Chimica Acta 90(6): 1112-1116.

15. Luo, H., Y. J. Liu, et al. (2007). 'Coprinus comatus damages nematode cuticles mechanically with spiny balls and produces potent toxins to immobilize nematodes.' Applied and Environmental Microbiology 73(12): 3916-3923.

16. Matheny, P. B., Z. Wang, et al. (2007). 'Contributions of rpb2 and tef1 to the phylogeny of mushrooms and allies (Basidiomycota, Fungi).' Molecular Phylogenetics and Evolution 43(2): 430-451.

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58 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

17. Melick, D. R., X. F. Yang, et al. (2007). 'Simplification of pine forests due to utilization by Tibetan villages in southwest China.' Environmental Management 40(6): 866-879.

18. Möller, M., L. M. Gao, et al. (2007). 'Morphometric analysis of the Taxus wallichiana complex (Taxaceae) based on herbarium material.' Botanical Journal of the Linnean Society 155(3): 307-335.

19. Nagano, H., Y. Iwazaki, et al. (2007). 'High diversity of Ligularia dictyoneura in chemical composition and DNA sequence.' Chemistry & Biodiversity 4(12): 2874-2888.

20. Nakata, M., K. Y. Guan, et al. (2007). 'Cytotaxonomy of Begonia rubropunctata and B· purpureofolia (Begoniaceae).' Botanical Journal of the Linnean Society 155(4): 513-517.

21. Penman, T. D., R. P. Kavanagh, et al. (2007). 'Patchiness of prescribed bums in dry sclerophyll eucalypt forests in South-eastern Australia.' Forest Ecology and Management 252(1-3): 24-32.

22. Pi, H. F., P. Zhang, et al. (2007). 'A new cycloartane triterpenoid from the leaves and stems of Fritillaria hupehensis.' Chinese Chemical Letters 18(4): 418-420.

23. Qiao, L. R., L. Yuan, et al. (2007). 'Tricycloalternarene derivatives produced by an endophyte Alternaria alternata isolated from Maytenus hookeri .' Journal of Basic Microbiology 47(4): 340-343.

24. Ruan, H. L., X. F. Zhou, et al. (2007). 'Ferulic acid esters from Euphorbia hylonoma.' Fitoterapia 78(1): 72-73.

25. Shi, S. Y., D. Y. Wu, et al. (2007). 'Four new eremophilendiolides from Ligularia atroviolacea.' Chinese Chemical Letters 18(1): 59-61.

26. Shi, S. Y., Q. Zhou, et al. (2007). 'Four new constituents from Taraxacum mongolicum.' Chinese Chemical Letters 18(11): 1367-1370.

27. Taechowisan, T., P. Tuntiwachwuttikul, et al. (2007). 'Anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells.' Immunological Investigations 36(2): 203-211.

28. Tan, A. M., H. P. He, et al. (2007). 'Two new sesquiterpenes from Ligularia lankongensis .' Helvetica Chimica Acta 90(1): 101-104.

29. Tori, M., M. Fujiwara, et al. (2007). 'New oplopane-type sesquiterpenoids from Ligularia duciformis.' Natural Product Communications 2(4): 357-360.

30. Torihata, A., R. Hanai, et al. (2007). 'Chemical and genetic differentiation of Ligularia tsangchanensis in Yunnan and Sichuan Provinces of China.' Chemistry & Biodiversity 4(3): 500-507.

31. Wang, L., W. L. Zhao, et al. (2007). 'Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappa B and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner.' Cell Death and Differentiation 14(2): 306-317.

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59Annual Report 2007

32. Wang, Y. S., J. H. Yang, et al. (2007). 'New cytotoxic steroid from Stachyurus himalaicus var. himalaicus.' Molecules 12(3): 536-542.

33. Welti, R., J. Shah, et al. (2007). 'Plant lipidomics: Discerning biological function by profiling plant complex lipids using mass spectrometry.' Frontiers in Bioscience 12: 2494-2506.

34. Wen, J., Z. L. Nie, et al. (2007). 'Phylogeny of Vitaceae based on the nuclear GAI1 gene sequences'.' Canadian Journal of Botany-Revue Canadienne De Botanique 85(8): 731-745.

35. Wu, L., Y. Lu, et al. (2007). 'Study on the spatial structure of annomuricatin A, a cyclohexapeptide from the seeds of Annona muricata.' Journal of Molecular Structure 827(1-3): 145-148.36. Xie, C. Y., H. Zhu, et al. (2007). 'MFTZ-1, an actinomycetes subspecies-derived antitumor macrolide, functions as a novel topoisomerase II poison.' Molecular Cancer Therapeutics 6(11): 3059-3070.

37. Xu, M., D. Wang, et al. (2007). 'Dammarane triterpenoids from the roots of Gentiana rigescens.' Journal of Natural Products 70(5): 880-883.

38. Yan, F. L., L. B. Zhang, et al. (2007). 'Two new diterpenoids from Isodon serra .' Chinese Chemical Letters 18(11): 1383-1385.

39. Yan, F. L., L. B. Zhang, et al. (2007). 'Two new diterpenoids and other constituents from Isodon serra.' Journal of Chemical Research-S(6): 362-364.

40. Yang, S. X., J. M. Gao, et al. (2007). 'Chemical constituents from Craibiodendron yunnanense.' Helvetica Chimica Acta 90(8): 1477-1481.

41. Ye, G., H. Peng, et al. (2007). 'Ellagic acid derivatives from the stem bark of Dipentodon sinicus.' Chemistry of Natural Compounds 43(2): 125-127.

42. Ye, G., H. Peng, et al. (2007). 'A new hopane triterpene from Dipentodon sinicus (Celastraceae).' Biochemical Systematics and Ecology 35(12): 905-908.

43. Ye, M., X. J. Luo, et al. (2007). 'Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens , induces cell-cycle arrest in G1 phase via the ERK1/2 pathway.' Cancer Letters 258(2): 199-207.

44. Yong, M., G. Kun, et al. (2007). 'A new lignan from the seeds of Arctium lappa.' Journal of Asian Natural Products Research 9(6): 541-544.

45. Yu, X. Z., J. D. Gu, et al. (2007). 'Hexavalent chromium induced stress and metabolic responses in hybrid willows.' Ecotoxicology 16(3): 299-309.

46. Yu, Z. Y., Y. G. Liang, et al. (2007). 'Melissoidesin G, a diterpenoid purified from Isodon melissoides , induces leukemic-cell apoptosis through induction of redox imbalance and exhibits synergy with other anticancer agents.' International Journal of Cancer 121(9): 2084-2094.

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60 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

1. Sheng-Ji PEI, Ethnobotany. Shanghai: Shanghai Scientific and Technical Publishers, 2007.

2. Xing-Jiang LI,Da-Cheng ZHANG, Mu ZANG. Moss Flora of China (English Version).

Beijing: Science Press, 2007.

3. Hong WANG, Chang-Qin ZHANG, De-Zhu LI. Checklist of Seed Plants of Lijiang Alpine

Botanic Garden. Kunming: Yunnan Science & Technology Press, 2007.

4. Kai-Yun GUAN, Zong-Ming SHI. Rich and Varied Plants in Our World. Beijing: China

Forestry Publishing House

List of Monographs

47. Zeng, Y. B., W. L. Mei, et al. (2007). 'Two new epimeric pairs of iridoid from mangrove plant Scyphiphora hydrophyllacea.' Chinese Chemical Letters 18(12): 1509-1511.

48. Zhang, H. P., F. Chen, et al. (2007). 'Complete assignments of H-1 and C-13 NMR data rings A,B-seco limonoids from the seed of Aphanamixis polystachya.' Magnetic Resonance in Chemistry 45(2): 189-192.

49. Zhang, Y. H., X. L. Yang, et al. (2007). 'A new veratramine alkaloid from the bulbs of Fritillaria hupehensis.' Chinese Chemical Letters 18(2): 175-177.

50. Zhao, Y., X. M. Niu, et al. (2007). 'Synthesis and cytotoxicity of some new eriocalyxin B derivatives.' European Journal of Medicinal Chemistry 42(4): 494-502.

51. Zheng, X., J. Du, et al. (2007). 'A new steroid from Selaginella pulvinata.' Fitoterapia 78(7-8): 598-599.

52. Zhou, C. X., X. Y. Zhang, et al. (2007). 'Three new diarylheptanoids and their antioxidant property.' Chinese Chemical Letters 18(10): 1243-1246.

53. Zhou, L. G., D. Li, et al. (2007). 'Two ellagic acid glycosides from Gleditsia sinensis Lam. with antifungal activity on Magnaporthe grisea.' Natural Product Research 21(4): 303-309.

54. Zhou, X. F., X. Y. Zhao, et al. (2007). 'Three new triterpenoid saponins from the rhizomes of Impatiens pritzellii var. hupehensis.' Journal of Asian Natural Products Research 9(4): 379-385.

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61Annual Report 2007

APPENDIX 3: LIST OF PATENTS APPLIED AND GRANTED

Names of Patents Inventors Patent No. Application Date

Issue Date of Patent

Method for Seedling Propagation of Bulbiet Dasheen

LONG Chun-Lin, CHENG Zhi-Ying, LUO Ji-Ying ZL200410040723.0 2004-9-17 2007-12-19

A Pesticide against Powdery Mildew on Plants and its Preparation Methods and Application

HAO Xiao-Jiang, LI Yan-Mei, ZHANG Zhong-Kai, HE Hong-Ping, ZUO Guo-Ying

ZL200510010802.1 2005-5-11 2007-10-24

A Preparation Method for Gentiopicroside

XU Min, ZHANG Ying-Jun, WANG Dong, ZHANG Xiang-Yu, YANG Chong-Ren

ZL200510010922.1 2005-7-21 2007-10-24

Preparation Method for a Anti-HIV/AIDS Compound and Development & Utilization of Drug Combination Using Its Active Components

LI Rong-Tao, SUN Han-Dong, ZHENG Yong-Tang, WANG Rui-Rui, YANG Liu-Meng

ZL200410040750.8 2004-9-24 2007-9-19

Triterpenoid Compounds and Their Utilization

LI Rong-Ta, XIAO Wei-Lie, SHEN Yun-Ting, PENG Li-Yan, SUN Han-Dong

ZL200410079516.6 2004-10-22 2007-8-29

A Preparation Method for Corilagin

ZHANG Ying-Jun, XU Min, WANG Dong, YANG Chong-Ren

ZL200510010880.1 2005-6-23 2007-5-30

A Preparation Method for Anti-tumor Drug Combination and Its Application

QIU Ming-Hua, WANG Jin, DU Jiang, QIU Sheng-Xiang, ZHOU Lin

ZL200510010837.5 2005-6-3 2007-3-21

A Preparation Method for Anti-tumor Compound and Development of Drug Combination Using and Its Active Components

QIU Ming-Hua, SUN Li-Rong, QING Chen, ZHANG Yan-Li, PEI Sheng-Ji

ZL200410040506.1 2004-8-19 2007-2-7

List of National New Plant Varieties

List of Patents Granted 2007

Names of New Plant Varieties Breeders No. of Variety Right Application

DateIssue Date of Variety Right

Rhododendron ‘Xilinmen’ ZHANG Chang-Qin, HUANG Yuan, ZHANG Jing-Li, TIAN Wei 20070023 2006-2-17 2007-9-7

Rhododendron ‘Jiaoyan’ ZHANG Chang-Qin, HUANG Yuan, GAO Lian-Ming 20070028 2006-2-17 2007-9-7

Rhododendron ‘Xuemeiren’

ZHANG Chang-Qin, WU Zhi-Kun, ZHANG Jing-Li, SUN Bao-Ling, TIAN Wei, QIAO Qin

20070024 2006-2-17 2007-9-7

Rhododendron ‘Hongyun’ ZHANG Chang-Qin, FENG Bao-Jun, GAO Lian-Ming 20070025 2006-2-17 2007-9-7

Rhododendron molle ‘Jinzhizhu’

ZHANG Chang-Qin, HUANG Yuan, GAO Lian-Ming 20070026 2006-2-17 2007-9-7

Rhododendron ‘Ziyan’ ZHANG Chang-Qin, HUANG Yuan, GAO Lian-Ming 20070027 2006-2-17 2007-9-7

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62 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

Invention Names Applicant (s) Inventors Applicationdate Application No.

A Preparation Method for Natural Sweet Compound, Iditol

KIBLIU Xi-Kui, XIAO Jian-Chun, LV Chun-Chao

2007.1.26 200710065642.X

Anti-Hepatitis B Drug KIBCHEN Ji-Jun, WU Ying-Rui, ZHAO You-Xing, MA Yun-Bao, YAO Shu-Ying, ZHOU Jun

2007.3.13 200710065709.X

A Method for Making of Biodiesel KIB

QIU Ming-Hua, YAN Jian, QIU You, YANG Ye-Kun, ZHANG Xiao-Xiao, LI Zhong-Rong

2007.3.13 200710065710.2

Preparation Method for Chemical Activator and Its Application

KIB, Institute of Biotechnology and Germplasm Resources, YAAS

HAO Xiao-Jiang, LI Yan-Mei, CHEN Gang, LUO Xiao-Dong, ZHANG Zhong-Kai, HE Hong-Ping

2007.3.19 200710065721.0

Preparation Method for Plant Endophyte

KIBWANG Hao-Xin, ZENG Ying, SHEN Yue-Mao

2007.3.19 200710065724.4

P r e p a r a t i o n M e t h o d for Hel ic ide Huperzine A A l d i m i n e a n d I t s Application

KIBQIU Ming-Hua, YAN Jian, YANG Fu-Mei, YANG Xiao-Sheng, ZHOU Lin, YI Ping

2007.4.20 200710065827.0

Preparation Method for Derivative of Huperzine A and Its Application

KIBQIU Ming-Hua, YAN Jian, YANG Fu-Mei, YI Ping, ZHOU Lin, YANG Xiao-Sheng, SUN Qian-Yun

2007.4.20 200710065824.7

Preparation Method for A c e t y l c h o l i n e s t e ra s e I n h i b i t o r a n d I t s Application

KIBQIU Ming-Hua, YAN Jian, YANG Fu-Mei, YI Ping, ZHOU Lin, YANG Xiao-Sheng

2007.5.11 200710065861.8

Breeding Method for a New Hybrid Variety of Dysosma, Dysosma × honghua

KIBGONG Xun, PAN Yue-Zhi, YANG Zhi-Yun, ZHANG Qi-Tai, YUE Zhong-Shu

2007.5.11 200710065862.2

Breeding Method for a New Variety of Michelia, Michelia × wanchun

KIBGONG Xun, PAN Yue-Zhi, YANG Zhi-Yun, ZHANG Qi-Tai, YUE Zhong-Shu

2007.5.11 200710065865.6

Breeding Method for a New Variety of Michelia, Michelia × yilan

KIBGONG Xun, PAN Yue-Zhi, YANG Zhi-Yun, ZHANG Qi-Tai, YUE Zhong-Shu

2007.5.11 200710065864.1

Breeding Method for a New Variety of Magnolia, Magnolia × yujuan

KIBGONG Xun, PAN Yue-Zhi, YANG Zhi-Yun, ZHANG Qi-Tai, YUE Zhong-Shu

2007.5.11 200710065863.7

Preparation Method for Flazin Analogues and Its Application

KIBLIU Ji-Kai, QING Chen, TANG Jian-Guo, LI Chun-Lei, DONG Ze-Jun, ZHANG Yan-Li

2007.4.12 200710065801.8

A s e p s i s S o w i n g o f Cymbidium tortisepalum and Method for Tissue Culture

KIBLONG Chun-Lin, CHENG Zhi-Ying, LUO Ji-Feng

2007.6.8 200710065941.3

P r e p a r a t i o n M e t h o d for N-OR Acetan i l ide-Group Compound and Its Application

KIB ZHU Hua-Jie, LV Xiao-Jie 2007.6.15 200710065964.4

Preparation Method for 6`-

O-caffeoyl ArbutinKIB

ZHAO Ping, ZHANG Ying-Jun, XU

Min, YANG Chong-Ren2007.6.14 200710065956.X

List of Patents Applied 2007

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63Annual Report 2007

Invention Names Applicant (s) InventorsApplication

DateApplication No.

Method for Breeding and Propagation of a New Variety of Rhododendron, Rhododendron 'Xuemeiren'

KIBZHANG Chang-Qin, WU Zhi-Kun, Qiao Qin, ZHANG Jing-Li, SUN Bao-Ling, TIAN Wei

2007.6.27 200710066000.1

Method for Breeding and Propagation of a New Variety of Rhododendron, Rhododendron ‘Jiaoyan’

KIBZHANG Chang-Qin, ZHANG Jing-Li, TIAN Wei, MA Yong-Peng, HUANG Yuan, GAO Lian-Ming

2007.6.27 200710066001.6

Method for Breeding and Propagation of a New Variety of Rhododendron, Rhododendron ‘Xilinmen’

KIBZHANG Chang-Qin, ZHANG Jing-Li, TIAN Wei, MA Yong-Peng

2007.6.27 200710065999.8

Method for Breeding and Propagation of a New Variety of Ardisia japonica, Ardisia mamillata ‘Baimaozhan’

KIBZHANG Chang-Qin, Wu Zhi-Kun, SUN Bao-Ling, GAO Ze-Rui, HUANG Yuan, LONG Qing-Lin

2007.6.27 200710066002.0

Preparation Method for Cyclopeptide and Its Application

KIB CHENG Yong-Xian, LV Qing 2007.7.13 200710066034.0

Production Method for Pile-Fermentation of a Pu-Er Ripe Tea

KIB

CHEN Ke-Ke, ZHU Hong-Taom WANG Dong, YANG Chong-Ren, ZHANG Ying-Jun, ZHANG Xiang-Lan

2007.8.30 200710066150.2

Preparation Method for Prepared Chinese Angelica and Its Application

KIBZHANG Ying-Jun, XU Min, CHEN Jiang-Tao, WANG Dong, YANG Chong-Ren

2007.8.30 200710066149.X

An Anti-Depression Drug and Its Application

KIB, Kunming Institute of Zoology, Kunming Jingbiao Biotech Co., Ltd.

CHEN Ji-Jun, XU Lin, ZHOU Jun, LV Jun, MAO Rong-Rong, TIAN Meng, SHEN Yong, JIANG Zhi-Yong

2007.8.3 200710066088.7

Anti-Depression Drugs and

Application

KIB, Kunming Institute of Zoology, Kunming Jingbiao Biotech Co., Ltd.

CHEN Ji-Jun, XU Lin, ZHOU Jun, LV Jun, MAO Rong-Rong, TIAN Meng, ZHANG Xue-Mei, SHEN Yong

2007.8.3 200710066089.1

Preparation Method for Anti-Tumor Activity Compound and Its Application

KIBPU Jian-Xin, SUN Han-Dong, XIAO Wei-Lie, LI Rong-Tao, HUANG Sheng-Xiong

2007.8.1 200710138589.1

Notoginseng and Standard Extract of Notoginseng, PN450 and Their Application

KIBWANG Dong, LIAO Peng-Ying, ZHANG Ying-Jun, YANG Chong-Ren

2007.9.14 200710066195.X

Preparation Method for Carboline Compound and Its Application

KIBZHU Hua-Jie, JIANG Ju-Xing, REN Jie

2007.11.9 200710066368.8

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64 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

List of Patents Applied and Granted 2007

Invention Names Applicant (s) Inventors Applicationdate Application No.

A Preparation Method for Natural Sweet Compound, Iditol

KIBLIU Xi-Kui, XIAO Jian-Chun, LV Chun-Chao

2007.1.26 200710065642.X

Anti-Hepatitis B Drug KIBCHEN Ji-Jun, WU Ying-Rui, ZHAO You-Xing, MA Yun-Bao, YAO Shu-Ying, ZHOU Jun

2007.3.13 200710065709.X

A Method for Making of Biodiesel KIB

QIU Ming-Hua, YAN Jian, QIU You, YANG Ye-Kun, ZHANG Xiao-Xiao, LI Zhong-Rong

2007.3.13 200710065710.2

Preparation Method for Chemical Activator and Its Application

KIB, Institute of Biotechnology and Germplasm Resources, YAAS

HAO Xiao-Jiang, LI Yan-Mei, CHEN Gang, LUO Xiao-Dong, ZHANG Zhong-Kai, HE Hong-Ping

2007.3.19 200710065721.0

Preparation Method for Plant Endophyte

KIBWANG Hao-Xin, ZENG Ying, SHEN Yue-Mao

2007.3.19 200710065724.4

Preparation Method for Helicide Huperzine A Aldimine and Its Application

KIBQIU Ming-Hua, YAN Jian, YANG Fu-Mei, YANG Xiao-Sheng, ZHOU Lin, YI Ping

2007.4.20 200710065827.0

Preparation Method for Derivative of Huperzine A and Its Application

KIBQIU Ming-Hua, YAN Jian, YANG Fu-Mei, YI Ping, ZHOU Lin, YANG Xiao-Sheng, SUN Qian-Yun

2007.4.20 200710065824.7

Preparation Method for Acetylcholinesterase Inhibitor and Its Application

KIBQIU Ming-Hua, YAN Jian, YANG Fu-Mei, YI Ping, ZHOU Lin, YANG Xiao-Sheng

2007.5.11 200710065861.8

Breeding Method for a New Hybrid Variety of Dysosma, Dysosma × honghua

KIBGONG Xun, PAN Yue-Zhi, YANG Zhi-Yun, ZHANG Qi-Tai, YUE Zhong-Shu

2007.5.11 200710065862.2

Breeding Method for a New Variety of Michelia, Michelia × wanchun

KIBGONG Xun, PAN Yue-Zhi, YANG Zhi-Yun, ZHANG Qi-Tai, YUE Zhong-Shu

2007.5.11 200710065865.6

Breeding Method for a New Variety of Michelia, Michelia × yilan

KIBGONG Xun, PAN Yue-Zhi, YANG Zhi-Yun, ZHANG Qi-Tai, YUE Zhong-Shu

2007.5.11 200710065864.1

Breeding Method for a New Variety of Magnolia, Magnolia × yujuan

KIBGONG Xun, PAN Yue-Zhi, YANG Zhi-Yun, ZHANG Qi-Tai, YUE Zhong-Shu

2007.5.11 200710065863.7

Preparation Method for Flazin Analogues and Its Application

KIBLIU Ji-Kai, QING Chen, TANG Jian-Guo, LI Chun-Lei, DONG Ze-Jun, ZHANG Yan-Li

2007.4.12 200710065801.8

Asepsis Sowing of Cymbidium tortisepalum and Method for Tissue Culture

KIBLONG Chun-Lin, CHENG Zhi-Ying, LUO Ji-Feng

2007.6.8 200710065941.3

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65Annual Report 2007

Invention Names Applicant (s) InventorsApplication

DateApplication No.

Preparation Method for N-OR Acetanilide-Group Compound and Its Application

KIB ZHU Hua-Jie, LV Xiao-Jie 2007.6.15 200710065964.4

Preparation Method for 6`-O-caffeoyl Arbutin

KIBZHAO Ping, ZHANG Ying-Jun, XU Min, YANG Chong-Ren

2007.6.14 200710065956.X

Method for Breeding and Propagation of a New Variety of Rhododendron, Rhododendron ‘Jiaoyan’

KIB

ZHANG Chang-Qin, ZHANG Jing-Li, TIAN Wei, MA Yong-Peng, HUANG Yuan, GAO Lian-Ming

2007.6.27 200710066001.6

Method for Breeding and Propagation of a New Variety of Ardisia japonica, Ardisia mamillata ‘Baimaozhan’

KIB

ZHANG Chang-Qin, Wu Zhi-Kun, SUN Bao-Ling, GAO Ze-Rui, HUANG Yuan, LONG Qing-Lin

2007.6.27 200710066002.0

An Anti-Depression Drug and Its Application

KIB, Kunming Institute of Zoology , Kunming Jingbiao Biotech Co., Ltd.

CHEN Ji-Jun, XU Lin, ZHOU Jun, LV Jun, MAO Rong-Rong, TIAN Meng, SHEN Yong, JIANG Zhi-Yong

2007.8.3 200710066088.7

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66 中国科学院昆明植物研究所年报 2007中国科学院昆明植物研究所年报 2007Annual Report 2007

Editor-in-chief: LI De-Zhu

Associate Editors-in-chief: SUN Hang, YANG Yong-Ping, LIU Ji-Kai & GAN Fan-Yuan

Editorial Committee: WANG Yu-Hua, WU Shu-Guang, QIAN Jie, ZHOU Zhe-Kun, PENG Hua,

TAN Ning-Hua, ZHAO Qin-Shi, SUN Wei-Bang, LI Wei-Qi, YANG Xiang-Yun &

ZHOU Bing

Executive Editors: QIAN Jie & WANG Yu-Hua

Proofreading:

HUANG Lu-Lu & ZHANG Jian-Wen

Designer: WU Yan