Annual Report 2006 - Nerve Research Foundation - PDF

Annual Report 2006

TThhee NNeerrvvee RReesseeaarrcchh FFoouunnddaattiioonn | The University of SydneyIInnssttiittuuttee ooff CClliinniiccaall NNeeuurroosscciieenncceess | Royal Prince Alfred Hospital

CCoovveerr IImmaaggeeSection through a peripheral nerve showing antibodies staining the compact myelin of the Schwann cell using blood from apatient with CIDP. The nerve fibre is in the centre and is not stained

TThhee NNeerrvvee RReesseeaarrcchh FFoouunnddaattiioonnIInnssttiittuuttee ooff CClliinniiccaall NNeeuurroosscciieenncceess

Annual Report 22000066 | 11 |

CCoonntteennttss

Highlights .......................................................................................................2

Directors’ Report - Nerve Research Foundation ...............................................3

Members of the Nerve Research Foundation 2006..........................................4

Chairman’s Report - Institute of Clinical Neurosciences, RPAH .........................5

Research 2006 - University of Sydney.............................................................6

Research 2006 - Royal Prince Alfred Hospital ...............................................11

Staff of the Nerve Research Foundation 2005 ...............................................14

Higher Degree Students 2006 - University of Sydney ....................................14

Staff of the Institute of Clinical Neurosciences (RPA Hospital) .........................15

Refereed Publications ...................................................................................18

Published Conference Proceedings and Abstracts.........................................22

Invited Lectures and Seminars.......................................................................23

Statement of Income and Expenditure - Nerve Research Foundation..............24

Balance Sheet - Nerve Research Foundation ...............................................25

Research Grants...........................................................................................26

2006 Record of Attendances - Institute of Clinical Neurosciences ..................27

Benefactors ..................................................................................................28

| 22 | Annual Report 22000066

Professor Clive Harper won the prestigious Royal Prince Alfred Hospital Research

Prize for 2006 for his outstanding work in alcohol related brain diseases and his

pioneering work in Brain Banking.

Recent advances in Multiple Sclerosis immunopathology by Professor Prineas

and his team highlighted at the European Conference for the Treatment and

Management of Multiple Sclerosis (ECTRIMS) Madrid 2006.

Professor Armati edited the first textbook on Schwann Cells "The Biology of

Schwann Cells” to be published by Cambridge University Press in January 2007.

Schwann Cells produce and maintain the insulating myelin membrane

surrounding nerves in the peripheral nervous system.

The Bannigan Prize for the best PhD for 2005 was awarded to Ariel Arthur.

Associate Professor Michael Besser was elected Chairman of the Greater

Metropolitan Clinical Taskforce for Neurosurgery, Deputy Chairman of

Neurooncology group for the NSW Cancer Group and Member of the

Clinical Council of the Clinical Excellence Commission.

HHiigghhlliigghhttss


DDiirreeccttoorrss’’ RReeppoorrttNNeerrvvee RReesseeaarrcchh FFoouunnddaattiioonn

In 2006 the Nerve Research Foundation strongly supported research at the

University of Sydney and Royal Prince Alfred Hospital by providing much needed

funds to assist projects in Multiple Sclerosis, Motor Neuron Disease, Peripheral

Neuropathy, Pain & Dementia. Foundation funds helped purchase vital

equipment for research projects, provided salaries for young research workers,

travel funds for PhD students to attend important international congresses and

funds to purchase chemicals and other essential to complete their research

projects. Work supported by the Foundation is described in this report.

Although progress in research appears to be slow, important advances have

been made by NRF research workers. Professor Prineas and his team, including

Drs. Michael Barnett, Andrew Henderson & John Parrott have made important

new findings regarding the immunopathology of Multiple Sclerosis which has

made a profound international impact and is changing the direction of MS

research. The keynote lecture at the major international MS Symposium held in

Madrid in 2006 featured this important work. Dr. Lin's experiments with

intravenous immunoglobulin have begun to define the role of this important

therapy and raised the possibility of alternate and more affordable modes of

preparation.

It has been particularly pleasing to see so many post graduate students

successfully complete their higher degree, particularly students from overseas

who will take back to their homelands expertise and technologies which will enrich

the local research environment. The role of the NRF in supporting young

researchers and post graduate students is a most important one, particularly in

these days when education has become so expensive. Because of this

expense, many students spend valuable time working to support their education,

leaving little time for research activities. By providing student scholarships, we

have been able to provide some students the possibility to follow their research

aspirations.

We are greatly indebted to our benefactors, many of whom have given generously

to the Foundation over many years. In particular, we wish to thank Mr Stephen

Ainsworth & Mrs Nanette Ainsworth, Mr John Armati, Mr & Mrs James Graham,

Dr Ruth Kerr and Mr & Mrs Alston. Corporate donors, Schering & Biogen Idec

have continued their generous help.

We are most grateful to all who have given of their time, financial assistant and

enthusiasm to help us in our endeavours to improve the lot of those with these

chronic neurological disorders.

PPrrooffeessssoorr JJ DD PPoollllaarrdd -- CCoo--ddiirreeccttoorr

AAssssoocciiaattee PPrrooffeessssoorr PP JJ AArrmmaattii -- CCoo--ddiirreeccttoorr

John Pollard

Patricia Armati



MMeemmbbeerrss ooff tthhee NNeerrvvee RReesseeaarrcchh FFoouunnddaattiioonn22000066

CCoouunncciillMr R Low, Vice President

Professor JD Pollard AO, Co-Director

Associate Professor PJ Armati, Co-Director

Hon Justice Kim Santow, Chancellor, Sydney University

Ms Renata Kaldor, Deputy Chancellor, Sydney University

Ms R O’Neill

Mr J Armati, AOM

Dr R Kerr

Dr J Milburn

Dr J Walsh

Mr R Wallace

Professor R Ouvrier

SScciieennttiiffiicc CCoommmmiitttteeee Professor J Pollard AO

Associate Professor P Armati

Professor R Ouvrier

Professor A Coates

HHoonnoorraarryy GGoovveerrnnoorrss Ms R O’Neill

Mr J Armati, AOM

HHoonnoorraarryy LLiiffee MMeemmbbeerrss Mr DL Jacobs

Ms R O’Neill

Dr R Kerr

Mr J Baker

Mr E Barnum

Mr R Wallace

Mr S Carroll AO


CChhaaiirrmmaann’’ss RReeppoorrttIInnssttiittuuttee ooff CClliinniiccaall NNeeuurroosscciieenncceess,, RRPPAAHH

The last twelve months have seen many changes in neurosciences, and it has

been an honour and a privilege to once again serve as Chairman of the

Neurosciences management committee. Overall there has been significant

forward momentum in many aspects of our service adding even more optimism

to the work we can do and the care we can bring to our patients in the future.

The intraoperative MRI scanner has now been installed and will soon be in

operation. This is the first such unit in the country, and will no doubt revolutionise

the treatment we can offer for patients suffering from brain tumours and other

pathologies. Applications and interviews were held for a fifth neurosurgeon to join

our ranks this year, and we hope to have a successful applicant appointed to staff

in 2008. This will help greatly with succession planning into the future.

Funds have been dedicated to building a new stereotactic radiosurgery machine

to be run jointly by neurosurgery and radiation oncology. This will employ state of

the art frameless stereotaxy techniques, and will add significantly to the treatment

options for patients with a wide range of illnesses. Very likely it will attract interest

from patients and their doctors from all over the state. We look forward to the

appointment of a new neurosurgeon (bringing our total number to six) and a new

radiation oncologist who will be primarily responsible for getting the service up and

running now and into the future. The RPAH Neurosciences Tumour Board chaired

by Michael Fulham continues to meet every two weeks and helps plan a

multidisciplinary approach to some of our more challenging cases. We have

welcomed Michael Jackson who has now alternated with Mo Mo Tin in providing

radiation oncology services.

Much work has been done by our nursing staff with regard to smooth transitions

between ICU and the ward, preserving our envious record of resource utilisation

and patient flow. The times when patients or procedures are cancelled due to bed

issues are rare enough to be notable, despite an increasing demand from both

the operating theatres and interventional neuroradiology. A dedicated "falls room"

with close nursing supervision remains a project of merit and has been in

operation since January 2007. Skills are being improved with 75% of permanent

staff on 8W2 now being accredited in completing PTA assessment of head

injured patients, and skills training in other procedural tasks such as insertion of

fine bore NG tubes. No fewer than three members of staff have attained CNS

qualifications this year reflecting the degree of commitment and enthusiasm

amongst our nurses. The management of stroke, the treatment of afflicted

patients and its prevention remain priorities of care. Changes include the

appointment of a new stroke fellow and equipment up-grade including the

purchase of a new stroke chair to aid in the early rehabilitation of patients.

These are only some of the developments over the last twelve months, and of

course all credit is due to the day by day small achievements from members of

staff at all levels and in all disciplines which combine to the rejuvenated corps

d'esprit within the institute. With all of this momentum propelling us forward, one

can not but look forward to developments over the next twelve months.

Jeffrey BrennanChairman, ICN Management Committee


Jeffrey Brennan


RReesseeaarrcchh 22000066

UUnniivveerrssiittyy ooff SSyyddnneeyy

PPEERRIIPPHHEERRAALL NNEEUURROOPPAATTHHYY

Inflammatory Neuropathies

Inflammatory neuropathies constitute the commonest treatable neuropathies in

the western world. Researchers at the Nerve Research Foundation have been

studying clinical features, pathogenesis and aspects of therapy of these

neuropathies.

CLINICAL FEATURES OF INFLAMMATORY NEUROPATHIES

V. Arjunamani, G. Harris, J. Spies, M.X. Wang, J.D. Pollard

The inflammatory neuropathies are comprised of an acute disorder, the Guillain-

Barré Syndrome (GBS) and a chronic disorder, chronic inflammatory

demyelinating polyneuropathy (CIDP). The recognition of clinical subtypes of GBS

set the stage for major advances in understanding pathogenesis since unique

mechanisms of disease production were then seen in these different subtypes.

Likewise, different subtypes of CIDP have been defined and we are studying

electrophysiological pathological and immunological characteristics and response

to therapy in these different types. These studies have contributed to guidelines

for disease management.

THE ROLE OF ANTI-GANGLIOSIDE ANTIBODIES IN NERVE INJURY

M. David, J. Spies, P.J. Armati, K. Sheik, J.D. Pollard

Gangliosides are glycolipids which are strongly associated with the plasma

membranes and are concentrated in neural membranes. Within the plasma

membrane they are concentrated in regions referred to as lipid rafts, which are

important sites of signal transduction and are associated with sites of

endocytosis. Certain subtypes of GBS are associated with antibodies to

gangliosides. Antibodies to the ganglioside GQ1b are virtually pathognomonic of

the Miller Fisher Syndrome and antibodies to GM-1 and GD1a occur frequently in

acute motor axonal neuropathy (AMAN). Interestingly, anti GD1a antibodies bind

preferentially to motor axons (and others such as GD1b bind to sensory axons)

and this finding helps explain the clinical features of these neuropathies. Since

these anti GM-1 and GD1a antibodies have not been directly shown to be

pathogenic, we performed studies in which monoclonal antibodies to GM-1 and

GD1a were passively transferred to experimental animals and electrophysiological

and histological studies were used to determine neuropathic effects. Monique

David previously presented the results of direct intraneural injection of these

antibodies whereas she has recently studied pathogenicity when the antibodies

were given systemically and the blood nerve barrier was rendered leaky by

intraneurally injected activated T Cells. GD1a antibodies were shown to produce

marked axonal degeneration in this rat model, whereas GM-1 antibodies did not.

These results show for the first time that GD1a antibodies cause motor axonal

degeneration, and provide the pathogenetic mechanism for acute motor axonal

neuropathy in man. In continuing studies, the site of binding of these antibodies

is being studied.

Supported by NH & MRC and the Nerve Research Foundation.


IMMUNOPATHOLOGY OF INFLAMMATORY NEUROPATHIES

G. Harris, M.X. Wang, J.D. Pollard

A majority of patients with CIDP respond to plasma exchange therapy (and

intravenous immunoglobulin) suggesting an important role for antibody in disease

pathogenesis. However, routine immunofluorescence studies have shown

antibodies bound to nerve only in a minority of patients. Ms. Harris, a third year

honours medical student and Dr. Wang have used an immunoperoxidose

technique to detect antibody on nerve and found this to be far more sensitive.

This technique has shown that antibody is present in a far higher percentage of

CIDP patients.

Another important finding from the studies is that 2 different patterns of binding

have been shown. One pattern indicates binding to compact myelin; the other to

uncompacted Schwann cell. This latter finding suggests as yet undefined target

antigens may be involved in disease pathogenesis.

Supported by Philip Bushell Foundation/NH&MRC

THE MECHANISM OF ACTION OF INTRAVENOUS IMMUNOGLOBULIN

S.S. Lin, J. Spies, M.X. Wang, J.D. Pollard

Intravenous Immunoglobulin (IVIg) is the first line of therapy for inflammatory

neuropathy world wide. Treatment of these neuropathies has become one of the

major consumers of this precious resource and in Australia costs about 60 million

dollars annually. Our group is investigating the mechanism of action of IVIg, since

understanding this mechanism may allow the development of more effective and

affordable therapy. Many patients in developing countries cannot afford this

expensive therapy.

Two major theories for its action in neuropathy have been proposed. One theory

proposes that human immunoglobulin contains an immense diversity of natural

antibodies, some of which neutralise harmful antibodies (such as those described

above) in patients with neuropathy. This diversity results from the fact that each

individual contains within their immunoglobulin fraction, many hundreds of

thousands of antibodies and each bottle of IVIg used in treatment contains

immunoglobulin from between five and fifty thousand donors.


Section through a peripheral nerveshowing antibodies staining thecompact myelin of the Schwann cellusing blood from a patient with CIDP.The nerve fibre (axon) is in the centreand is not stained (left)

Section through the same nerve, alsoshowing antibody staining, but in thiscase the non-compact region of theSchwann cell immediatelysurrounding the nerve fibre and thenon-compact outermost region of theSchwann cell is stained. The compactmyelin is not stained (right)

The difference in staining between thetwo images shows for the first timethat CIDP is a complex disease with anumber of different target antigens.


Such diversity would be extremely difficult to create pharmaceutically. The other

major theory proposes that the constant region of immunoglobulin the Fc

component, down regulates immune responses by reacting with particular

receptors on the surface of phagocytic cells. If this mechanism was shown to be

the dominant one, it would be possible to manufacture artificial Fc components of

immunoglobulin. Dr. Lin, a visiting Taiwanese Neurologist has studied the

mechanism of action of IVIg in an animal model of inflammatory neuropathy and

showed that the efficacy depends upon the Fc (constant) portion rather than the

variable (Fab) component. Further studies are underway to more clearly define

the mechanism of action but this important finding suggests that it may be

possible to product an effective immunoglobulin by molecular technology and

thus conserve this most precious resource.

Supported by NR & MRC, NSW Health and the Philip Bushell Foundation.

PERIPHERAL NEUROPATHY IN CHILDHOOD

R Ouvrier

Professor Robert Ouvrier has continued his studies on peripheral neuropathy in

childhood. In local collaboration with Dr Simon Grew, Prof Garth Nicholson, Prof

John Pollard and Dr Monique Ryan and with Prof Jean-Michel Vallat (Limoges,

France), a 25 year followup study has been undertaken of a severe form of

inherited childhood polyneuropathy, first delineated by our group. Genetic analysis

by Dr Danqing Zhu at Concord and Dr Corinne Magdelaine (France) has revealed

that mutations of a gene involved in energy production are responsible for about

half of such cases. This was the first demonstration of a particular mode of

inheritance in this disorder. Prof Ouvrier was also involved in studies of Critical

Illness Polyneuropathy, a serious but reversible form of neuromuscular disease

affecting mainly Intensive Care Unit patients which won Dr Monique Ryan the prize

for the Best Presentation on Nerve Disorders at the International Congress on

Neuromuscular Disorders, Istanbul, July 2006. Professor Ouvrier was elected to

the Presidency of the International Child Neurology Association in June 2006 for

a term of four years.

MMUULLTTIIPPLLEE SSCCLLEERROOSSIISS

GENE EXPRESSION IN MULTIPLE SCLEROSIS

A Arthur, P.J. Armati, J.D. Pollard

In May of 2006, Ariel Arthur was awarded her PhD which was supervised by

Assoc Prof Patricia Armati. Due to the very generous support of Mr Stephen

Ainsworth and the Nerve Research Foundation, Dr Arthur was able to continue

her research in multiple sclerosis throughout 2006. As a result, the Ainsworth MS

research project was established which has involved an extension of Dr Arthur's

PhD work, investigating gene expression in the peripheral blood of relapsing

remitting (RR) MS patients, with a focus on mild MS disease, compared to healthy

controls. This research has generated a comprehensive profile of gene

expression in RRMS during relapse, remission and in patients with very mild

disease. Dr Arthur has also been working with Dr Simon Hawke at the Brain and

Mind Research Institute to examine gene expression in blood vessels obtained

from MS brain tissue, which has complemented her work in MS peripheral blood.


MULTIPLE SCLEROSIS

J.W. Prineas, J.D.E. Parratt, M.H. Barnett, A Henderson

Despite recent advances in multiple sclerosis therapeutics, the pathogenesis of

this disease remains incompletely understood and the cause, enigmatic. We have

proposed that examination of the earliest MS lesions will yield pathological

information essential to understand this complex condition. Accordingly, we

continue to investigate such early lesions on three main fronts.

First, elaborating upon research published in 2004, we definitively prove that

oligodendrocyte cell death (the myelin producing central nervous system cell)

occurs by a process known as apoptosis. This intriguing finding raises the

possibility that death of oligodendrocytes results in much of the myelin loss from

MS patients' brains and may be one of the key, initiating steps to disease. We are

currently studying the distribution and cellular associations of such dying

oligodendrocytes to determine potential causes. This work will be published

towards the end of 2007.

Once myelin loss begins, an inflammatory response occurs, the details of which

are only, at present, hypothesis. Dr. Henderson's examination of these early,

inflammatory changes identified a clear sequence of events and two novel

findings. First, a specialised cell, the dendritic cell, appears near blood vessels in

the demyelinating tissue. This cell, previously thought to be absent from the brain,

most likely plays a role by inciting a targeted immune process against

components of the nervous system (such as oligodendrocytes or myelin).

Second, the predominant cell to arrive and potentially cause further damage is the

CD8 T-lymphocyte. Previously thought to be primarily a CD4 T-lymphocyte

disease, this new finding raises the possibility that these potent CD8 positive

"killers" may be damaging oligodendrocytes/myelin or other components of the

nervous system such as nerve cells and their processes (axons) directly.

Dr. Parratt has furthered this work identifying that CD8 T-cells change shape on

entry to the brain, cluster in areas of probable interest and express molecules,

called granzymes, which upon injection into a target cell cause death.

Investigations are currently underway to identify potential targets of these "killer" or

cytotoxic T-cells. The research is supported by an MS society grant ($120 000)

which the team won in October 2006 and publications are expected by the end

of 2007.

Our third and final mode of investigation has recently been summarised by Dr.

Barnett and Professor Prineas and submitted for publication. Investigating new

lesions for evidence of MS specific proteins involved in nervous tissue damage,

the researchers found that neither immunoglobulins nor a closely associated

immunological molecule were specifically distributed in MS lesions compared with

other neurological diseases. An area of controversy, this work suggests that

complement and immunoglobulins cannot be used to segregate different MS

subtypes. The team did, however, identify areas in normal appearing brain of MS

patients (rather than lesions) where one immune protein appears to stick

specifically to segments of myelin. This fascinating finding raises the possibility

that such areas of myelin may contain the so-called "MS antigen" or in other

words, represent the potential brain target for immune cells.


| 1100 | Annual Report 22000066

In general, the progress cited, has allowed the group to develop a new paradigm

for the pathogenesis of MS. Dr. Barnett and Dr. Parratt have presented the work

at several conferences including the Australian and New Zealand Annual

Neurologists conference and the Biogen Idec Postgraduate Neurology meeting.

Collaboration with Professor Stuart Cook, (Professor of Neurology, University of

Medicine and Dentistry of New Jersey, Newark, New Jersey, U.S.A) is underway

investigating constituent myelin proteins and their abnormalities in lesions and

normal appearing brain sections of MS patients. Finally, this year will see

collaboration with Professor Richard Reynold's team, at Imperial College, London

investigating the immunological evolution of the MS plaque.

NNEEUURROOOONNCCOOLLOOGGYY

MOLECULAR CARCINOGENISIS PROGRAM

G Marshall, C Vacher, E Sekyere, PJ Armati

The cure rates for many childhood cancers have markedly improved over the past

three decades, nevertheless many cancers remain resistant to therapy. Moreover,

chemotherapy and radiotherapy can leave the patient with severe short- and long-

term side effects.

The work of the Molecular Carcinogenesis Program is focussed on the

mechanisms involved in cancer initiation, using neuroblastoma (nerve cancer) as

model. Neuroblastoma, together with medulloblastoma and acute lymphoblastic

leukaemia represent more than half of childhood cancers and have the common

feature of starting in an embryonal normal cell. Very little is known about the

mechanisms that cause embryonal cell persistence, or how these cells undergo

further changes that lead to cancer in some children.

Our work has also pinpointed the exact part of the protein that is required to

cause these changes. The successful completion of this work has far-reaching

effects on prevention or strategies for the early detection of cancer in children.

Catherine Vacher is using microarray technology to identify new target genes

which may play a vital role in the initiation of neuroblastoma. This study will allow

us to investigate over 30,000 genes to find which are critical for tumour initiation

and perpetuation.

Annual Report 22000066 | 1111 |

RReesseeaarrcchh 22000066

RRooyyaall PPrriinnccee AAllffrreedd HHoossppiittaall

NNEEUURROOPPAATTHHOOLLOOGGYY

MOTOR NEURON DISEASE

R Pamphlett

ALS is a disease of the nervous system that causes death in 2-5 years. A few

cases run in families, but usually only one family member is affected. We think that

in these latter people some gene is disordered in the nervous system only, not in

all cells of the body as is usual in genetic diseases. We are therefore looking for

gene abnormalities in the brains of people who had ALS. A new method using

gene chips will allow us to examine all the chromosomes for abnormalities as well.

ALCOHOL RESEARCH

C Harper, I Matsumoto

Pathology houses the New South Wales Tissue Resource Centre (NSW TRC).

The NSW TRC is a facility for the collection, storage and distribution of well

characterised fixed and frozen human brain tissue for neuropsychiatric research

(with a focus on schizophrenia and alcohol related disorders). The NSW TRC is

jointly supported by the Neuroscience Institute of Schizophrenia and Allied

Disorders, the University of Sydney, Sydney South West Area Health Service,

NH&MRC, the Rebecca Cooper Foundation and the National Institute of Alcohol

Abuse and Alcoholism.

The ability to collect human brain tissue is made possible through the

Departments of Forensic Medicine (DOFM) and the Australian Brain Donor

Programs (ABDP). The ABDP include; the 'Gift of Hope', (for major psychiatric

illnesses), 'Using our Brains' (for those without neuropsychiatric illness) and a

program for those with neurodegenerative illnesses. In 2006 we have

successfully collected seventy brains for use in research. In the 05/06 evaluation

period, tissue has been requested from 39 research groups for 56 projects.

An honorary visiting scholar - Xiahao He - spent the year with the Neuropathology

Unit carrying out a project in collaboration with Stanford University. This study

looked at the interaction of thiamine deficiency and alcohol in a rat model using

electron microscopy. Xiaohua He demonstrated that alcohol ingestion in thiamine

deficient rats caused significant damage in the corpus callosum.

Within neuropathology the 'Matsumoto lab' has been looking at changes in

protein expression in postmortem brain tissues of alcohol and schizophrenia

cases using new proteomic techniques. Using the combination of Laser capture

microscopy and PCR method, expression of NMDA receptor subunits has been

investigated in specific cell populations of both schizophrenic and alcoholic

brains.


| 1122 | Annual Report 22000066

NNEEUURROOPPSSYYCCHHOOLLOOGGYY

MEMORY AND MEMORY IMPAIRMENTS

L Miller

In 2006, we started a new line of research into the effectiveness of memory

training for patients with memory impairments caused by stroke, head injury or

epilepsy. Our main endeavour was to design and run a six-week course

appropriate for groups of patients with stable memory problems. A team of

neuropsychologists and students guided the participants through memory

exercises and taught them about external memory aids and life style factors that

affect memory. To test the effectiveness of the training, patients were assessed

before and after the course. Their performance on memory tests and their

everyday memory abilities (via questionnaires) were evaluated. Preliminary results

indicate gains in memory functioning in moving from the pre to the post-training

assessments, but the number of subjects enrolled thus far has been relatively

small. Once we complete the training and assessment of a third group of

participants (currently underway), the data will be pooled and analysed. We are

interested in examining whether ongoing epilepsy, site of brain lesion, IQ, and/or

age affects the successfulness of the training.

In addition to the six-week course, we collaborated with Epilepsy Action to design

and run (on several occasions) a one-day Memory Workshop for people with

seizures. We found that participants were able to learn a number of things about

how memory works and strategies they should try as a result of the course.

These findings were presented at the Australian Epilepsy Society meeting in

Melbourne. Finally, we have begun to run Carer Training Workshops for those

supporting patients with memory deficits. These have been tailor made to fit the

needs of (1) those caring for patients with stable memory impairment as well as

(2) those caring for patients with dementia. Thus far, these have only been

evaluated using satisfaction surveys, but participants have been full of praise for

this innovative intervention.

BBAALLAANNCCEE DDIISSOORRDDEERRSS

S T Aw, G M Halmagyi

Benign paroxysmal positional vertigo is the most common balance disorder,

accounting for about 30% of the 2500 patients seen last year at the Royal Prince

Alfred Hospital Balance Disorders Clinic. Semicircular canals are believed to

cause the symptoms of this disorder. During head movements, irritation of the

semicircular canals resulting in dizziness, vertigo, loss of balance and abnormal

eye movements. Our research focus on how to identify in which of the three, i.e.

the horizontal, superior or posterior semicircular canal, the crystals have become

misplaced. Once the problem is correctly located, the treatment consists of a

series of bedside particle repositioning manoeuvres to relocate the crystals into

the vestibule of labyrinth where they can no longer cause any irritation of the

balance sensors.

This balance disorder called superior canal dehiscence is due to the thinning of

the temporal skull bone resulting in an abnormal opening of the labyrinth at roof of

the superior semicircular canal. We have developed a more sensitive diagnostic

test using a click sound to identify this condition, which causes dizziness and loss

of balance in response to loud sounds and during sneezing or straining.


Annual Report 22000066 | 1133 |

In addition, patients also become abnormally sensitive to their own bodily sounds

such as hearing very loud footfalls, joints creaking and even blinking. The hearing

test from these patients often mimic a middle ear disorder which can sometimes

lead to unnecessary middle ear reconstruction surgery, if the condition is not

correctly diagnosed.

In patients with Meniere's disease who have undergone selective balance nerve

section sometimes continued to experience persistent dizziness even after the

surgery. Using MR imaging and reconstruction techniques, we have identified the

presence of residual balance nerve fibres that have not been sectioned due to

attempts to preserve hearing in these patients. Another area of our research is to

develop an electrical stimulation test of the balance organ and in order to use it to

diagnose common balance disorders such as benign tumour of the balance

nerve, Meniere's disease, vestibular neuritis and labyrinthitis.

NNEEUURROOSSUURRGGEERRYY

M Besser, A Davidson, B Shivalingam, J McMaster

THE FAMILIAL INTRACRANIAL ANEURYSM STUDY (FIA)

The FIA is an international, multi-centre study which aims to identify the gene (or

genes) associated with formation and rupture of intracranial aneurysms in families

with multiple affected family members. Recruitment of families to Phase 1 was

completed in 2006. Further research into potential genes continues into Phase 2

of the study.

HYDROCOIL ANEURYSM OCULUSION & PACKING STUDY (HELP)

Endovascular repair of ruptured and unruptured intracranial aneurysms provides

an alternative management option to microsurgery. The Hydrocoil is a platinum

spiral-shaped coil with a coating made of hydrogel (an acrylic polymer). When

exposed to water, hydrogel expands. The HELP Study is a prospective,

randomised, international multicentre trial comparing the results of Hydrocoil with

standard bare platinum coils. RPA Hospital continues to enrol patients with

intracranial aneurysms into this important trial.

SSTTRROOKKEE UUNNIITT

C Anderson

The Stroke Unit at Royal Prince Alfred Hospital is under the Directorship of

Professor Anderson, Professor of Stroke Medicine and Clinical Neuroscience at

the University of Sydney and Director of the Neurological and Mental Health

Division in The George Institute for International Health. As a clinician-scientist,

Professor Anderson is responsible for overseeing the conduct of large scale

randomised controlled trials and epidemiological projects in populations for the

development of new strategies for the prevention and treatment of stroke and

other aspects of cerebrovascular disease. Some of these projects involve the

recruitment of subjects, either as in-patients or out-patients, at Royal Prince Alfred

Hospital as a clinical research site, while other projects are being undertaken

overseas, particularly in China and India. Professor Anderson is responsible for a

dozen staff in Sydney and indirect responsibility for the activities of several

hundred further staff working in more than 100 overseas institutions.

| 1144 | Annual Report 22000066

SSttaaffff ooff tthhee NNeerrvvee RReesseeaarrcchh FFoouunnddaattiioonn22000066Academic Staff

Prof J Pollard, AO BSc (Med) MB BS PhD, FRACP, FRCP

A/Prof P Armati, BSc, MSc, PhD

Professor J Prineas, MB BS, FRCP, FRCP (Edin)

Emeritus Professor JG McLeod, AO, MB BS, BSc (Med), DPhil (Oxon),

DSc, Hon DU (Aix-Marseille), FRCP (Lond), FRACP, FAA, FTSE

Dr J Spies, MB BS PhD, FRACP

Dr A Mohammed, MB BS, FRACP

Dr M Wang MB MD

Dr J Parrott MB BS MD

HHiigghheerr DDeeggrreeee SSttuuddeennttss22000066

NNEERRVVEE RREESSEEAARRCCHHFFOOUUNNDDAATTIIOONNDDooccttoorr ooff PPhhiilloossoopphhyy ((PPhhDD))

P Spring

C Kok

T Lin

S S Lin

M Barnett

M David

J Lu

F Wang

C Vacher

R Chow

HHoonnoouurrss MMeeddiiccaall SSttuuddeennttssMMBB BBSS ((HHoonnss))

G Harris

N Jufas

D Raper

V Arjunamani

R Norrad

DDeeggrreeeess AAwwaarrddeedd

R Owe-Young

P Spring

IINNSSTTIITTUUTTEE OOFF CCLLIINNIICCAALLNNEEUURROOSSCCIIEENNCCEESSDDooccttoorr ooff PPhhiilloossoopphhyy ((PPhhDD))

S Savage

W Tham

K Richardson

M Say

J Morahan

N Luquin

N Lambert

K Alexander

T Iwazaki

D Wheeler

R Dempsey

MMaasstteerr ooff SScciieennccee ((MMSScc))

S Jacek

M Abul Kashem

HHoonnoouurrss ssttuuddeennttss ((HHoonnss))

R Coxon

N Caixeiro

M Nesvaderani

Clinical Trials StaffL Pallot RN, Trials Co-ordinator

G Pallot

Technical Staff Mr Toan Nguyen

Ms Jiew

Post Doctoral FellowsDr A Arthur BSc(Hons) PhD

Research AssistantsB Roediger BSc(Hons)

N Jufas BSc(Med)

Annual Report 22000066 | 1155 |

SSttaaffffIInnssttiittuuttee ooff CClliinniiccaallNNeeuurroosscciieenncceessRRooyyaall PPrriinnccee AAllffrreeddHHoossppiittaall DDeeppaarrttmmeenntt ooff NNeeuurrooppaatthhoollooggyy Senior Medical Staff Prof CG Harper, MB BS, FRCPA

A/Prof Izuru Matsumoto, MD, PhD

A/Prof RS Pamphlett, MD, FRACP,

FRCPath

Dr C Burke - Registrar

Senior Research Staff Mr R Stankovic, BSc, Snr Scientific

Officer

Mrs D Sheedy, BA, Research

Assistant

Ms T Garrick RN, TRC Manager

Ms A Green, BA Hon, Clinical

Psychologist

Senior Technical Staff Mr S Kum Jew

NNeeuurrooppssyycchhoollooggyy UUnniitt Clinical Staff Dr L A Miller, PhD, MSc, BSc, MAPS

Dr N Breen, MSc, BSc, MAPS

Ms Z Thayer

Dr D Horry, PhD

Administrative Staff Ms M Satkunarajah

Ms J Ho

Honorary Staff Dr D Caine, PhD, MSc, BSc, MAPS,

Clinical Neuropsychologist

DDeeppaarrttmmeenntt ooff PPEETT && NNuucclleeaarrMMeeddiicciinnee Clinical Staff Prof MJ Fulham, FRACP Director

Dr A Mohamed, Staff Specialist

Dr K Allman MB BS

Dr H Son MB BS

D H Kim MB BS

Scientific Staff Dr S Eberl, BE, MSc, MACPSEM

Dr R Fawdry, PhD

Dr R Fulton, BAppSc, MACPSEM

Mr D Henderson, BAppSc,

GradDipSc, MRACICChem

Mr J Verschuer BSc

Mr E Lim BCST(Hons)

Ms J Towson, MSc

Nursing Staff Mr E Francia, RN

Ms M Nicholls, RN

Ms J Pillay, RN

Ms P Fleming, RN

Technologist Staff Ms J Brackenreg, BAppSci (MRT)

Chief Technologist,

Mr D Rainey, DipMRT, Senior

Technologist

Ms S Meikle, Technologist

Mr A Lawler, Technologist

Mr A Waugh, Technologist

Ms S Baker, Technologist

Ms J Santhanam, Technologist

Ms A Sullican, Technologist

Mr B Tandy, Technologist

M Yosufzai, Technologist

Administrative Staff Mrs H Burke, Data & Office Manager

Ms J Guerrero , Receptionist/Typist

Ms K Burrows, Secretary

Ms M O'Rouke, Secretary

Research Staff M Gibson BAppSci (HIM)

DDeeppaarrttmmeenntt ooff NNeeuurroollooggyy Director of Neurology Clin Prof GM Halmagyi, MB BS, BSc

(Med), MD FRACP

Neurologists Clin A/Prof L Davies MB BS

FRACP MD

Clin A/Prof J Ell, MB BS, FRACP

Clin Prof MJ Fulham, MB BS, FRACP

Dr A Mohamed, MBBS, FRACP

Prof JD Pollard, AO MB BS, BSc

(Med), PhD, FRACP, FRCP, Bushell

Professor of Neurology, Academic

Head

Dr J Spies, MB BS, PhD, FRACP,

Associate Neurologists Dr A Bleasel, PhD, MB BS, FRACP

Prof C Anderson MB BS PhD FRACP

Prof GA Broe, AM, BA, MB BS, FRACP

Dr P Cremer, MB BS, BSc (Med)

Dr J Frith, PhD, MB BS, FRACP

Dr J Gordon, MB BS, FRACP

Dr JK Graham, MB BS, FRACP

Dr SR Hammond, PhD, MB BS,

FRACP, MRCP

Dr RT Lorentz, MB BS, FRCP, FRACP

Prof R Ouvrier, MB BS, BSc (Med),

FRACP

Dr D Serisier, MB BS, BSc (Med),

FRACP

Dr C Yiannikas, MB BS, FRACP

Honorary Consultant Neurologists Dr J Allsop, AO, MB BS, FRACP

Prof JG McLeod, AO, MB BS, BSc

(Med), DPhil (Oxon), DSc, Hon DU

(Aix-Marseille), FRCP (Lond), FRACP,

FAA, FTSE, Professor Emeritus,

Neurologist

Dr J Leicester, MB BS, FRACP

Dr J Walsh, MB BS BSc (Med) MD

Advanced Trainees in Neurology Dr M Thurtell MB BS MSc

Dr K Sharp MB BS

Dr J Burrell MB BS

Clinical Neurophysiology Unit Clin A/Prof L Davies MB BS PhD

FRACP (Head)

Dr A Mohamed, MBBS, FRACP

Dr J Spies, MB BS, PhD, FRACP

Dr S Jankelowitz MB BS, PhD,

FRACP

Prof D Burke AO MB BS BSc(Med)

PhD FRACP FAA

Ms A Francis, RN

Ms A White, RN

Ms A O’Connell, BN, CNS

Ms T Ottavio, BN, RN, NUM

Ms J Boserio, CNS

Ms N Reid, RN

Ms M Pereira, BN, RN

Ms E Sheridan, BA, CNS

Central Sydney Area HealthServices, Neurosciences Clin. A/Prof M Besser, MB BS,

FRACS, FRCSC (C), FACS

Mr J O’Sullivan, Business Manager

Honorary Neuroscientists Prof M Bennett, BE, MSc, PhD, DSc,

FAA

Dr RJ Bandler, BA, PhD, DSc, FAA

Prof GAR Johnston PhD MSc FRACI

A/Prof PJ Armati, MSc, PhD

Dr T-L Chan Ling, M Optom, PhD,

FAAO


| 1166 | Annual Report 22000066

DDeeppaarrttmmeenntt ooff NNeeuurroossuurrggeerryy Director Clin. A/Prof M Besser AM, MB BS,

FRACS, FRCSC (C), FACS

Neurosurgeons Dr MG McGee-Collett, MB BS,

FRACS

Dr JW Brennan, BSc, MB BS, FRACS

Dr R Allen, MB BS FRACS

Honorary ConsultantNeurosurgeons Prof RS Gye, AO, MA (Oxon), Hon

MD (Syd), DPhil (Oxon), BSc (Med),

MB BS

Clin. A/Prof IH Johnston, MD ChB,

PhD, BSc, FRACS, FRCS

Honorary Associate Neurosurgeon Dr N W Dorsch, MB BS, FRACS,

FRCS

Senior Research Staff Clin. A/Prof IH Johnston, AO, MD

ChB, PhD, BSc, FRACS, FRCS

Senior Technical Staff Ms V Dunne

Advanced Trainees inNeurosurgery Dr B Shivalingam MB BS

Dr J McMaster MB BS

Dr A Davidson MB BS

IInnssttiittuuttee ooff CClliinniiccaall NNeeuurroosscciieenncceessMMaannaaggeemmeenntt CCoommmmiitttteeeeDr J Brennan BSc MB BS FRACS,

Director

Clin A/Prof L Davies, Neurology

Clin A/Prof M Besser, Neurosurgery

Ms D Brine, Nurse Unit Manager

Ms V Sutherland, Clinical Nerve

Consultant

Mr J O’Sullivan, ICN, Clinical Manager

Sr F Hopkins, Nurse Unit Manager,

ICU

Ms B Vale, Allied Health

Ms N Morely, Occupational Therapy

PPaaiinn MMaannaaggeemmeenntt CCeennttrree Senior Medical Staff Dr J D Ditton, MB BS, FANZCA,

FFPMANZCA, Head of Department

Dr M Jennings, MB BS, FRANZCP,

FRACP(C), FFPMANZCA, Psychiatrist

Dr A Aggarwal, MB BS, FRACP,

FAFRM(RACP), FFPMANZCA, Rehab.

Medicine

Ms A Helou, Grad Dip Soc Com,

MScMED(PM),

Clinical Nurse Consultant Clinical

Coordinator

Ms J Cohen, M Psych (Clin) MAPS,

Clinical Psychologist

Ms J Keller, RN

Consultants Dr P Stalley, MB BS, FRACS, FAOrth

A, Orthopaedic Surgeon

Dr M McGee-Collett, MB BS (Syd)

FRACS, Neurological Surgeon

Dr P Glare, FRACP, FFPMANZCA,

Cancer Pain & Palliative Medicine

Dr L Martin, BDS (Hons), Head,

Dentistry

Dr C Senior, MB BS (Hons) FRACOG,

Gynaecologist

NNeeuurroooottoollooggyy UUnniitt Clinical and Research Dr S Aw, MB BS, PhD, Scientific

Officer

Ms A Burgess, PhD, NHMRC RA

Ms S Burton-Bradley, RN

Mr A J Camp, BSc, RA

Prof JG Colebatch, MB BS, PhD,

FRACP, Associate Neurologist

Mrs Jane Collingwood, BA,

Audiologist

Prof IS Curthoys, BA, PhD,

Consultant Psychologist

Dr JJ Ell, MB BS, FRACP,

Visiting Neurologist

Prof G M Halmagyi, MB BS,

BSc(Med), FRACP, Staff Neurologist

Ms I Hannigan, CNS

Ms K de Lapp, BS, Physiotherapist

Mr H Macdougall, BSc, RA

Mr M O'Brien, BA, Psychologist

Ms M Pereira, BN, RN

Ms A Francis, RN

Dr D V Pohl, MB BS, FRACS

Ms L Sokolic, MSc, RA

Mr C Tsang, BA, Audiologist

Ms H Uzun, BMedSc, M App Sc, RA

Mr C Whitfeld, BSc, Audiologist

Ms R Yavor, Clinical Nurse Specialist

Annual Report 22000066 | 1177 |


Administrative Staff Ms M Amarilla

Ms I Menezes

Ms R Stojanovska

Ms H Mistry

Mr O Kudzu

Computing and Engineering Mr M Todd, BE(Elec), MBiomedE,

Chief Biomedical Engineer

Mr M Bubicic, Technical Officer

Mr A Cartwright, Computer

Programmer

Ms T Le, BE, Network Engineer

Mr L McGarvie, BE(Mech),

MBiomedE, Biomedical Engineer

Mr S Pratap, Technical Officer

Mr J Bryant, Technical Officer

DDeeppaarrttmmeenntt ooff PPssyycchhiiaattrryy Dr T Hance, MB BS, FRANZCP,

Acting Director

Dr K Kerr MB BS, FRANZCP

Dr M Robertson MB BS, FRANZCP

Dr A Trenaman MB BS, FRANZCP

Dr V Sundakov MB BS, FRANZCP

Dr R Gertler MB BS, FRANZCP

A/Prof J Russell MB BS, FRANZCP

Prof I Hickie MB BS, PhD, FRANZCP

Dr R Gribble MB BS, FRANZCP

Dr M Corr MB BS, FRANZCP

Dr K Morris MB BS, FRANZCP

Dr R White MB BS, FRANZCP

Dr M Jennings MB BS, FRANZCP

Dr G Barnes MB BS, FRANZCP

DDeeppaarrttmmeenntt ooff RRaaddiioollooggyy Neuroradiology Dr Richard Waugh, Acting Director

Dr G Parker, MB BS, FRACR

Dr E Thompson, MB BS, FRACR

Dr J Soper, MB BS, FRACR

Dr R Doss, MB BS, FRACR

Dr S Nagaratnam, MB BS, FRACR

Dr J Magnussen, MB BS, FRACR

DDeeppaarrttmmeenntt ooff RReehhaabbiilliittaattiioonnMMeeddiicciinneeDr P Henke, MB BS, DPRM, FACRM,

Head

Dr A Aggarwal MB BS FRACP

FACRM

Dr C Winer, LLB, MB BS, FACRM,

MRCS, DRCOG, MLCOM, DPRM

Dr I Nair MB BS FACRM

Mr M O’Brien, BA, DipRehabCouns,

MaPsS, Psychologist

DDeeppaarrttmmeenntt ooff OOttoollaarryynnggoollooggyySenior Medical Staff Dr G R Croxson, MB BS, FRACS,

Clinical Head

Professor W P R Gibson, AM, MD,

FRACS, FRCS, Professor of

Otolaryngology, Academic Head

Dr M Mendelsohn, MB BS, FRACS

Dr A Clifford, MB BS, FRACS, VMO

Dr D Pohl, MB BS, FRACS, Senior

VMO

Senior Technical Staff Dr H Sanli, PhD, Scientific Officer,

Cochlear Implant Unit

Vocational Registrars in Training Dr T Pincock

Dr D Novakovic

Visiting Fellows Dr N Mansell/Dr P Valentine

Audiologists Dr D Rockey

Dr C-S Tsang

Ms M Bray

Ms C Pearce

AAlllliieedd HHeeaalltthh Ms K Eu, BEc, BSoc Admin, Director

Ms B Vale, BAppSc(OT), Assistant

Director

Ms R Ray, BAppSc(OT), Occupational

Therapist

Ms K Williams, BAppSc(Phys),

Physiotherapist

Ms M Lam, BAppSc(Phys),

Physiotherapist

Ms J Young, BAppSc(Phys),

Physiotherapist

Ms K Garvey, BAppSc(SpPath),

Speech Pathologist

Ms R Manusu, BAppSc(SpPath),

Speech Pathologist

Ms M Doctor, BSW, MSW, Social

Worker

Ms C Robinson, BSW, Social Worker

Ms E Frigg, BSc, MND, Dietitian

DDeeppaarrttmmeenntt ooff NNuurrssiinngg EE77 Mr J O’Sullivan, Clinical Manager, ICN

Ms V Sutherland, RN, MN, Clinical

Nurse Consultant, ICN

Ms N Moorley, RN, Nursing Unit

Manager

Ms A O’Connell, RN

Ms R Grenenger, RN

Ms D Kirkley RN, Nursing Unit

Manager, Intensive Care Unit

Ms J Sherlock

Ms J Raftesath

| 1188 | Annual Report 22000066

RReeffeerrrreedd PPuubblliiccaattiioonnss

Alexander-Kaufman, K, Harper, C,

Matsumoto, I. A proteome analysis of the

dorsolateral prefrontal cortex in human

alcoholic patients. Alcoholism-Clinical and

Experimental Research. 2006; 30:157

Alexander-Kaufman, K, James, G, Sheedy,

D, Harper, C, Matsumoto, I. Differential

protein expression in the prefrontal white

matter of human alcoholics: a proteomics

study. Molecular psychiatry. 2006; 11:56-65

Arima H, Chalmers J, Woodward M,

Anderson C, Rodgers A, Davis S,

Macmahon S, and Neal B. Lower target

blood pressures are safe and effective for

the prevention of recurrent stroke: the

PROGRESS trial; J Hypertens. 24 (6):1201-

1208, 2006.

Arima H, Tzourio C, Butcher K, Anderson c,

Bousser MG, Lees KR, Reid JL, Omae T,

Woodward M, Macmahon S, Chalmers J.

Prior events predict cerebrovascular and

coronary outcomes in the PROGRESS trial;

Stroke 37 (6):1497-1502, 2006.

Aw ST, Magnussen JS, Todd MJ,

McCormack S, Halmagyi GM. MRI of the

vestibular nerve after selective vestibular

neurectomy. Acta Otolaryngol 2006;

126(10):1053-1056.

Aw ST, Todd MJ, Aw GE, Magnussen JS,

Curthoys IS, Halmagyi GM. Click-evoked

vestibulo-ocular reflex: stimulus-response

properties in superior canal dehiscence.

Neurology 2006; 66(7):1079-1087.

Aw ST, Todd MJ, Halmagyi GM. Latency and

initiation of the human vestibuloocular reflex

to pulsed galvanic stimulation. J

Neurophysiol 2006; 96(2):925-930.

Azizi, L, Garrick, T, Harper, C. Brain donation

for research: strong support in Australia.

Journal of clinical neuroscience : official

journal of the Neurosurgical Society of

Australasia. 2006; 13:449-52

Bakalkin, G, Marinova, Z, Okvist, A, Bazov, I,

Sheedy, D, Garrick, T, Harper, C, Ekstrom, T.

Presynaptic dysfunction associated with

adaptations in cell suicide machinery in

alcoholics: Biochemical evidence.

Alcoholism-Clinical and Experimental

Research. 2006; 30:55

Barnett MH, Henderson AP, Prineas JW. The

macrophage in MS: just a scavenger after

all? Pathology and pathogenesis of the acute

MS lesion. Mult Scler. 2006;12:121-132

Barnett MH, Sutton I. The pathology of

multiple sclerosis: a paradigm shift. Curr

Opin Neurol. 2006;19:242-247

Blundo, C, Ricci, M, Miller, L. Category-

specific knowledge deficit for animals in a

patient with herpes simplex encephalitis.

Cognitive Neuropsychology. 2006; 23:1248-

1268

Brown, R, Tennant, C, Sharrock, M,

Hodgkinson, S, Dunn, S, Pollard, J.

Relationship between stress and relapse in

multiple sclerosis: part I. Important features.

Multiple Sclerosis. 2006; 12:453-464

Brown, R, Tennant, C, Sharrock, M,

Hodgkinson, S, Dunn, S, Pollard, J.

Relationship between stress and relapse in

multiple sclerosis: part II. Direct and indirect

relationships. Multiple Sclerosis. 2006;

12:465-475

Buckley, S, Foley, P, Innes, D, Loh, E, Shen,

Y, Williams, S, Harper, C, Tannenberg, A,

Dodd, P. GABA(A) receptor beta isoform

protein expression in human alcoholic brain:

interaction with genotype. Neurochemistry

International. 2006; 49:557-567

Burns J, Landorf KB, Ryan MM, Crosbie J,

Ouvrier RA. Interventions for the prevention

and treatment of pes cavus. (Protocol)

Cochrane Database of Systematic Reviews

2006, Issue 3.

Annual Report 22000066 | 1199 |

Burns J. Crosbie J. Hunt A. Ouvrier R. The

effect of pes cavus on foot pain and plantar

pressure.] Clinical Biomechanics.

2005;.20:877-82

Burns, J, Crosbie, J, Ouvrier, R, Hunt, A.

Effective orthotic therapy for the painful

cavus foot: a randomized controlled trial.

Journal of the American Podiatric Medical

Association. 2006; 96:205-11

Chiong, M, Marinaki, A, Duley, J, Bennetts,

B, Ouvrier, R, Christodoulou, J. Lesch-Nyhan

disease in a 20-year-old man incorrectly

described as developing 'cerebral palsy' after

general anaesthesia in infancy. Journal of

inherited metabolic disease. 2006; 29:594

Cisternas, P, Armati, P. The immunolymphatic

system. In: Marsupials. Cambridge, UK:

Cambridge University Press 2006. p.186

Davies, R, Kipps, C, Mitchell, J, Kril, J,

Halliday, G, Hodges, J. Progression in

Frontotemporal Dementia: Identifying a

Benign Behavioral Variant by Magnetic

Resonance Imaging. Archives of neurology.

2006; 63:1627-1631

Dedova, I, Garrick, T, Sheedy, D, Hanks, E,

Hunt, C, Dedov, V, Harper, C. Brain banking

for neuroscience: Helping scientists find

causes and cures for neuropsychiatric

disorders. Alcoholism-Clinical and


Ekstrom, T, Garrick, T, Harper, C, Sheedy, D,

Hurd, Y, Bakalkin, G, Johansson, S.

Validation of endogenous expression

controls for studying gene expression in

motor and frontal cortices of human chronic

alcoholics. Alcoholism-Clinical and


Garrick, T, Glaw, X, Harper, C, North, A. The

diagnosis is critical for psychiatric brain

banks: an interrater reliability study. The

Australian and New Zealand journal of

psychiatry. 2006. p. 606-7

Garrick, T, Howell, S, Terwee, P, Redenbach,

J, Blake, H, Harper, C. Brain donation for

research: Who donates and why?. Journal of

clinical neuroscience : official journal of the

Neurosurgical Society of Australasia. 2006;

13:524-8

Garrick, T, Sheedy, D, Blake, H, Green, A,

Glaw, X, Harper, C. "Using Our Brains" -

Doing it down under. Alcoholism-Clinical and


Garrick, T, Terwee, P, Patching, J, Blake, H,

Harper, C. 'Using our Brains' who donates to

research and why?. Alcoholism-Clinical and

Experimental Research. 2006; 30:218A-

218A

Green, A, Garrick, T, Sheedy, D, Blake, H,

Harper, C. Alcohol and cognition as

measured by the repeatable battery for the

assessment of neuropsychological status.


Research. 2006; 30:136

Green, A, Garrick, T, Sheedy, D, Blake, H,

Harper, C. The repeatable battery for the

assessment of neuropsychological status

(RBANS): Normative data for Australian

adults. Alcoholism-Clinical and Experimental

Research. 2006; 30:160

Gregory, G, Macdonald, V, Schofield, P, Kril,

J, Halliday, G. Differences in regional brain

atrophy in genetic forms of Alzheimer's

disease. Neurobiol Aging. 2006; 27:387-93

Hackett ML and Anderson CS; Frequency,

management, and predictors of abnormal

mood after stroke: the Auckland Regional

Community Stroke (ARCOS) study, 2002 to

2003. Stroke 37 (8):2123-2128,2006.

Hadden, R, Nobile-Orazio, E, Sommer, C,

Hahn, A, Illa, I, Morra, E, Pollard, J, Hughes,

R, Bouche, P, Cornblath, D, Evers, E, Koski,

C, Leger, J, Van den Bergh, P, van Doorn, P,

Schaik, I. European Federation of

Neurological Societies Peripheral Nerve

Society guideline on management of

paraproteinaemic demyelinating

neuropathies: report of a joint task force of

the European Federation of Neurological

Societies and the Peripheral Nerve Society.

European Journal of Neurology. 2006;

13:809-818

Halliday, G, Song, Y, Creasey, H, Morris, J,

Brooks, W, Kril, J. Neuropathology in the

S305S tau gene mutation. Brain 2006; 129

Harper, C, Hinton, F, Garrick, T, McLean, C.

The Australian Brain Bank Network. J Neural

Transmission. 2006; 113:IV

Harper, C, Sheedy, D. Brain damage caused

by thiamine deficiency - The Australian

experience. Alcoholism-Clinical and


Harper, C. Thiamine (vitamin B1) deficiency

and associated brain damage is still

common throughout the world and

prevention is simple and safe!. European

journal of neurology : the official journal of the

European Federation of Neurological

Societies. 2006; 13:1078-82

He, X, Pfefferbaum, A, Sullivan, E, Harper, C.

A quantitative morphometric analysis of

myelinated fibres in corpus callosum

following thiamine deficiency and alcohol

exposure in the alcohol-preferring (P) rat.


Research. 2006; 30:159

Hughes, R et al European Federation of

Neurological Societies Peripheral Nerve

Society guideline on management of chronic

inflammatory demyelinating

polyradiculoneuropathy: report of a joint task

force of the European Federation of

Neurological Societies and the Peripheral

Nerve Society (Reprinted from Journal of the

Peripheral Nervous System, vol 10, pg 220-

228, 2005). European Journal of Neurology.

2006; 13:326-332


| 2200 | Annual Report 22000066

Kappos, L, Traboulsee, A, Constantinescu,

C, Eralinna, J, Forrestal, F, Jongen, P,

Pollard, J, Sandberg-Wollheim, M, Sindic, C,

Stubinski, B, Uitdehaag, B, Li, D. Long-term

subcutaneous interferon beta-1a therapy in

patients with relapsing-remitting MS.

Neurology. 2006; 67:944-953

Kashem, A, James, G, Sheedy, D, Harper,

C, Wilce, P, Matsumoto, I. Proteomics

studies on the corpus callosum of human

alcoholic brain. Alcoholism-Clinical and


Kashem, M, James, G, Harper, C, Wilce, P,

Matsumoto, I. Differential protein expression

in the corpus callosum (splenium) of human

alcoholics: A proteomics study.

Neurochemistry international. 2006;

Kersaitis, C, Halliday, G, Xuereb, J,

Pamphlett, R, Bak, T, Hodges, J, Kril, J.

Ubiquitin positive inclusions and early

pathology in frontotemporal lobar

degeneration and motor neuron disease.

Brain Pathology. 2006; 16:S43



Ubiquitin-positive inclusions and progression

of pathology in frontotemporal dementia and

motor neurone disease identifies a group

with mainly early pathology. Neuropathology

and applied neurobiology. 2006; 32:83-91



Ubiquitin positive inclusions and early

pathology in frontotemporal lobar

degeneration and motor neuron disease.

Brain Pathology. 2006; 16:S43



Ubiquitin-positive inclusions and progression

of pathology in frontotemporal dementia and

motor neurone disease identifies a group

with mainly early pathology. Neuropathology

and applied neurobiology. 2006; 32:83-91

Kril, J. Neuropathology of alcohol abuse: A

comparison with ageing and Alzheimer's

disease. Alcoholism-Clinical and

Experimental Research. 2006; 30:51A

Lah, S, Lee, T, Grayson, S, Miller, L. Effects

of temporal lobe epilepsy on retrograde

memory. Epilepsia. 2006; 47:615-25

Lambert, N, Swain, M, Miller, L, Caine, D.

Exploring the neural organization of person-

related knowledge: lateralization of lesion,

category specificity, and stimulus modality

effects. Neuropsychology. 2006; 20:346-54

Lu, J, Vallat, J, Pollard, J, Knoops, B,

Ouvrier, R. Expression of the antioxidant

enzyme peroxiredoxin 5 in the human

peripheral nervous system. Journal of the

peripheral nervous system : JPNS. 2006;

11:318-324

Lye, T, Grayson, D, Creasey, H, Piguet, O,

Bennett, H, Ridley, L, Kril, J, Broe, G.

Predicting memory performance in normal

ageing using different measures of

hippocampal size. Neuroradiology. 2006;

48:90-9

Lynch, G, Turville, S, Carter, B, Sloane, A,

Chan, A, Muljadi, N, Li, S, Low, L, Armati, P,

Raison, R, Zoellner, H, Williamson, P,

Cunningham, A, Church, W. Marked

differences in the structures and protein

associations of lymphocyte and monocyte

CD4: resolution of a novel CD4 isoform.

Immunology and cell biology. 2006; 84:154

Mandadi, S, Tominaga, T, Numazaki, M,

Murayama, N, Saito, N, Armati, P,

Roufogalis, B, Tominaga, M. Increased

sensitivity of desensitized TRPV1 by PMA

occurs through PKCepsilon-mediated

phosphorylation at S800. Pain. 2006;

123:106-16

Matsumoto, I, Alexander-Kaufman, K, Harper,

C. Alcohol-induced brain damage:

Proteomics on postmortem human brain.


Research. 2006; 30:85


Annual Report 22000066 | 2211 |

Morahan, J, Pamphlett, R. Amyotrophic

Lateral Sclerosis and Exposure to

Environmental Toxins: An Australian Case-

Control Study. Neuroepidemiology. 2006;

27:130-5

Morahan, J, Yu, B, Trent, R, Pamphlett, R. A

gene-environment study of the paraoxonase

1 gene and pesticides in amyotrophic lateral

sclerosis. Neurotoxicology. 2006

Nelson, J, Armati, P. The nervous system. In:

Marsupials : Cambridge University Press

2006.p159-185.

Peisah, C, Snowdon, J, Gorrie, C, Kril, J,

Rodriguez, M. Investigation of Alzheimer's

disease-related pathology in community

dwelling older subjects who committed

suicide. Journal of affective disorders. 2006

Pickering-Brown, S, Baker, M, Gass, J,

Boeve, B, Loy, C, Brooks, W, Mackenzie, I,

Martins, R, Kwok, J, Halliday, G, Kril, J,

Schofield, P, Mann, D, Hutton, M. Mutations

in progranulin explain atypical phenotypes

with variants in MAPT. Brain; a journal of

neurology. 2006. p. 3124-6

Piguet, O, Bennett, H, Waite, L, Kril, J,

Creasey, H, Anthony Broe, G, Halliday, G.

Preserved cognition and functional

independence after a large right posterior

cerebral artery infarct: longitudinal clinical and

neuropathological findings. Neurocase : case

studies in neuropsychology, neuropsychiatry,

and behavioural neurology. 2006; 12:81-90

Piguet, O, Cramsie, J, Bennett, H, Kril, J,

Lye, T, Corbett, A, Hayes, M, Creasey, H,

Broe, G. Contributions of age and alcohol

consumption to cerebellar integrity, gait and

cognition in non-demented very old

individuals. European archives of psychiatry

and clinical neuroscience. 2006; 256:504

Redmond, A, Crosbie, J, Ouvrier, R.

Development and validation of a novel rating

system for scoring standing foot posture:

The Foot Posture Index. Clinical

Biomechanics. 2006; 21:89-98

Ryan, M, Reddel, S, Nicholson, G, Ouvrier,

R. Dominant congenital non progressive

motor neuron disorder. Neuromuscular

Disorders. 2006; 16:S115-S115

Savage, G, Ray, F, Halmagyi, M, Blazely, A,

Harper, C. Stable neuropsychological deficits

in adult polyglucosan body disease. Journal

of clinical neuroscience : official journal of the

Neurosurgical Society of Australasia. 2006

Sheedy, D, Cartwright, M, Harper, C. Data

handling - The Hub of a Tissue Resource

Centre. Journal of Neural Transmission.

2006; 113:XI-XI

Sheedy, D, Garrick, T, Blake, H, Green, A,

Hunt, C, Harper, C. Managing the "wealth of

information" of an Australian brain tissue

bank. Alcoholism-Clinical and Experimental

Research. 2006; 30:160

Sheedy, D, Hunt, C, Harper, C. The effect of

alcohol and smoking on brain volumes - An

autopsy study. Alcoholism-Clinical and

Experimental Research. 2006; 30:217A-

217A

Sheedy, D, Hunt, C, Saihara, Y, Garrick, T,

Dedova, I, Harper, C. Maintaining quality of

the NSW Tissue Resource Centre.


Research. 2006; 30:160

Shingde, M, Spring, P, Maxwell, A, Wills, E,

Harper, C, Dye, D, Laing, N, North, K.

Myosin storage (hyaline body) myopathy: A

case report. Neuromuscular disorders :

NMD. 2006; 16:882-6

Smith S, Ouvrier RA. Peripheral Neuropathy

in: Swaiman K, Ashwal S, Ferriero DM (Eds.)

Pediatric Neurology 4th Edn Mosby

St.Louis, 2006, pp 1887-1918

Taylor, J, Pollard, J. Soluble TNFR1 inhibits

the development of experimental

autoimmune neuritis by modulating blood-

nerve-barrier permeability and inflammation. J

Neuroimmunology. 2006

van Schaik, I, Bouche, P, Illa, I, Leger, J, Van

den Bergh, P, Cornblath, D, Evers, E,

Hadden, R, Hughes, R, Koski, C, Nobile-

Orazio, E, Pollard, J, Sommer, C, Doorn, P.

European Federation of Neurological

Societies Peripheral Nerve Society guideline

on management of multifocal motor

neuropathy. Eur J Neuro. 2006; 13:802-808

Warrier S, Owler BK, and Besser M

Paraganglioma and paragangliomatosis of

the cauda equina. ANZ.J Surg. 76:1033-

1037, 2006.

Wheeler, D, Dixon, G, Harper, C. No

differences in calcium-binding protein

immunoreactivity in the posterior cingulate

and visual cortex: schizophrenia and

controls. Progress in neuro-

psychopharmacology & biological psychiatry.

2006; 30:630-9

Wheeler, D, Harper, C. Localised reductions

in gyrification in the posterior cingulate:

Schizophrenia and controls. Progress in

neuro-psychopharmacology & biological

psychiatry. 2006

Williams, S, Horrocks, I, Ouvrier, R, Gillis, J,

Ryan, M. Critical illness polyneuropathy and

myopathy in pediatric intensive care: A

review. Pediatric critical care medicine : a

journal of the Society of Critical Care

Medicine and the World Federation of

Pediatric Intensive and Critical Care

Societies. 2006

Yakovleva, T, Okvist, A, Bazov, I, Martinez, R,

Sheedy, D, Garrick, T, Harper, C, Ekstrom, T.

Downregulation of the NF-kappaB

transcription factors in the prefrontal cortex of

human alcoholics. Alcoholism-Clinical and


Zoing, M, Burke, D, Pamphlett, R, Kiernan,

M. Riluzole therapy for motor neurone

disease: an early Australian experience

(1996-2002). Journal of clinical

neuroscience : official journal of the

Neurosurgical Society of Australasia. 2006;

13:78-83

| 2222 | Annual Report 22000066

PPuubblliisshheedd CCoonnffeerreenncceePPrroocceeeeddiinnggss aannddAAbbssttrraaccttss 22000066

David MA, Spies JM, Pollard JD,

Zang G, Armati P, Sheikh KA,

Intraneural injections of anti-

ganglioside antibodies induce

reversible conduction failure.

Peripheral Nerve Society, Tuscany,

Italy, July 2005.

David MA, Spies JM, Pollard JD,

Zang G, Armati P, Sheikh KA, The

Role of anti-ganglioside antibodies in

nerve injury. 7th International

Congress of Neuroimmunology,

Venice, Italy, September 2004

Hepner, I., Mohamed, A., Hawkins,

S.H. Thompson, E.O., and Miller, L.

(2006). The effects of temporal lobe

and/or posterior cingulate lesions on

retrograde topographical memory.

International Conference on Memory,

16-21 July, 2006; Sydney, Australia.

International Conference on Memory,

16-21 July, 2006; Sydney, Australia.

Lah, S., Lee, T., Grayson, S., and

Miller, L. (2006). Temporal lobe

epilepsy and temporal lobectomy:

Impact of cognitive and seizure

variables on retrograde memory.

Miller, L., and O'Keefe, S. (2006).

Effectiveness of a One Day Memory

Training Workshop for Patients with

Epilepsy. Epilepsy Society of Australia

Meeting, 5-7 October, 2006;

Melbourne, Australia.

Miller, L.A., Monasterio, G. and

Harding, A. (2006). Retrograde

memory in patients with focal thalamic

stroke. International Conference on

Memory, 16-21 July, 2006; Sydney,

Australia.

Palermo, R., Miller, L. & Schmalzl, L.

(2006). Amygdalae and affective facial

expressions. International Society for

Behavioural Neuroscience Meeting, 4-

7 July, 2006; Bath, UK.

Palermo, R., Schmalzl, L., & Miller, L.

(2006). Affective priming from faces:

the influence of spatial frequency,

prime duration and amygdala

damage. Australian Journal of

Psychology: Supplement 58, 87.

[Australasian Experimental Psychology

Conference, 21-23 April, 2006;

Brisbane, Australia]

Annual Report 22000066 | 2233 |

IInnvviitteedd LLeeccttuurreess aannddSSeemmiinnaarrss

Aw ST, Garnett Passe and Rodney

Williams Memorial Foundation

Conference 2006.

Aw ST, International Congress of the

Barany Society 2006.

Aw ST, Neuro-Otology Society

Australia 2006.

Garrick T, Brain Banking for

Neuroscience Research, Wuhan

University - China.

Harper C, Brain Banking for

Neuropsychiatric Research, The

Australian Society for Psychiatric

Research Annual Meeting. Sydney.

Harper C, Brain Banking for

Neuroscience Research,

Neurosciences' Seminar, Royal Prince

Alfred Hospital. Sydney.

Harper C, Network of Brain Banks -

the Australian Experience, BrainNet

Europe II, Human Brain Tissue

Research International Conference.

Italy.

Harper C, Structural changes in

alcoholic brains. Peking Medical

School - China and Wuhan University

- China.

Harper C, Structural changes in

alcoholic brains. Special Lecture

Series. Research Society on

Alcoholism, Baltimore. USA.

Matsumoto I, Alcohol and Brain,

Seminar for general public, organized

by Sapporo Medical University,

Neuropsychiatry Department,

Sapporo, Japan

Matsumoto I, Alcoholism and

Schizophrenia; Mechanism and

treatment for comorbid cases,

Japanese Society of alcohol-related

problems, Sendai, Japan

Matsumoto I, Alcohol-Specific

Cascades Underlying Alcohol-Induced

Prefrontal Cortex Damage: Insight

from Proteomics Studies, ISBRA,

Sydney, Australia

Matsumoto I, Comorbid cases of

alcoholism and schizophrenia,

Seminar at Ishibashi Hospital, Otaru,

Japan

Matsumoto I, Latest Developments in

the Proteomic Analysis of Human

Alcoholic Brain, JASBRA, Sapporo,

Japan

Matsumoto I, Latest Developments in

the Proteomic Analysis of Human

Brain, Asian Pacific Society of

Neurochemistry, Singapore.

Matsumoto I, Latest developments in

the proteomic analysis of the human

alcoholic brain, Inter-Departmental

Substance Abuse Research Group

(ISARG) Program, Sydney, Australia

Matsumoto I, Proteomics in

psychiatric illnesses, Discovery

Science, Melbourne, Australia

Matsumoto I, Psychiatric medicine;

Japan vs Australia, Seminar at

Asahiyama Hospital, Sapporo, Japan

Miller L, Effects of Stroke on

Retrograde Memory: Invited talk to

Stroke Research Group, Bankstown

Hospital, Sydney

Miller L, Use of the ACE-R as a

screening tool for dementia: Invited

talk to the Neurology Dept, Royal

Prince Alfred Hospital

Pollard JD, Acute & Chronic

Demyelinating Neuropathies,

Australian and New Zealand

Association of Neurologists - Annual

Scientific Meeting, Canberra - May

2006

Pollard JD, Chronic Immune Mediated

Neuropathies, Annual Scientific

Meeting New Zealand Neurological

Association, Wellington - Nov 2006

Pollard JD, Chronic Immune Mediated

Neuropathies, S. Luigi Gonzaga

Hospital, Turino, Italy - Sept 2006

Pollard JD, GEMS MS Preceptorship,

Brain & Mind Research Institute,

Sydney - Dec 2006

Pollard JD, Immune Mechanisms in

Neuropathy, First International

Conference of Pacific Rim

Universities, Brain & Mind Research

Institute, Sydney - Oct 2006

Pollard JD, Mechanisms and

Management of Inflammatory

Neuropathy, Grand Rounds Austin

Hospital, Melbourne - June 2006

Pollard JD, Reflections on the Blood

Nerve/Brain Barrier, Austin Hospital

Research Group, Melbourne - June

2006

Sheedy D, Databasing for tissue

banks. Australasian Biospecimens

Network Conference. Melbourne


| 2244 | Annual Report 22000066

TThhee UUnniivveerrssiittyy ooff SSyyddnneeyyNNeerrvvee RReesseeaarrcchh FFoouunnddaattiioonn

SSttaatteemmeenntt ooff IInnccoommee aanndd EExxppeennddiittuurree ffoorr tthhee yyeeaarr eennddeedd 3311 DDeecceemmbbeerr 22000066

3311 DDeecceemmbbeerr 3311 DDeecceemmbbeerr22000066 22000055

$$ $$

INCOME

Grants and HECS 50,000 30,000

Scholarships/Donation/Bequests 180,800 176,183

Business & Investment Income 107,089 128,382

Fees & Charges 171,452 239,362

Other Income - 37,385

Total Income 509,341 611,312

EXPENDITURE

Salaries 314,093 206,479

Consumables 43,294 23,380

Equipment & Repairs/Maintenance 8,163 17,140

Services/Utilities 514 96

Travel/Conferences 8,342 29,412

Other expenses 57,735 108,023

Total Expenditure 432,141 384,530

SURPLUS FOR THE YEAR 77,200 226,782

Total Accumulated Funds as at 1 January 1,838,430 1,611,648

TOTAL ACCUMULATED FUNDS 1,915,630 1,838,430

Annual Report 22000066 | 2255 |

TThhee UUnniivveerrssiittyy ooff SSyyddnneeyyNNeerrvvee RReesseeaarrcchh FFoouunnddaattiioonn

BBaallaannccee SShheeeett aass aatt 3311 DDeecceemmbbeerr 22000066

3311 DDeecceemmbbeerr 3311 DDeecceemmbbeerr22000066 22000055

$$ $$

ASSETS

Current AssetsPrepayments - -

Investment-Cash Balance 1,715,630 1,638,430

Total Current Assets 1,715,630 1,638,430

Non-Current AssetsGrowth Fund Investment Pool 200,000 200,000

Total Fixed Assets 200,000 200,000

Total Assets 1,915,630 1,838,430

NET ASSETS 1,915,630 1,838,430

EQUITY

Accumulated Funds 1,915,630 1,838,430

TOTAL EQUITY 1,915,630 1,838,430

I certify that the Income Statement and Balance Sheet have been prepared in accordance with the University’s accounting

practices and procedures and reflect the transactions as recorded in the University’s general ledger.

M Easson BCom CA MBAFinance Director

Faculties of Health

February 23, 2007


| 2266 | Annual Report 22000066

RReesseeaarrcchh ggrraannttss22000066

TTiittllee GGrraannttiinngg BBooddyy $$ 22000066 Resurgent sodium currents in peripheral nerve axons Australia Research Council $270,000

(Kiernan, Conner) (2004-2006)

Understanding the variation in frontotemporal dementia National Health & Medical pa $136,750

(Kril, Creasey, Halliday) Research Council (2004-2006)

Brain Banking and Donor Programs National Health & Medical pa $500,000

Research Council (2004-2009)

Brain Tissue Resource Centre for Alcohol Research National Institute of Alcohol pa $650,000

Abuse and Alcoholism (2003-2008)

Brain Bank and Donor Program for Biomedical Research NSW BioFirst Award $400,000

into Schizophrenia and Alcohol related brain damage (2003-2006)

Studies in Prion Disorders Alberti Bequest for Clinical $1,400,000

(Hawke, Pollard, Harper) Neurological Research (2004-2009)

Somatic mutations in Motor Neuron Disease Motor Neuron Disease Association $22,000

(Pamphlett) of South Australia

DNA Bank for Motor Neuron Disease National Health & Medical pa $175,000

(Pamphlett, Laing, Trent, Yu) Research Council (2006-2011)

Role of viruses in Motor Neuron Disease Motor Neuron Disease Research $69,000

(Hansen, Pamphlett) Institute - Bill Gole Fellowship

Autobiographical Memory in Temporal Lobe Lesions Brain Foundation Grant $12,000

(Miller, Lah)

Glial and neuroinflammatory mechanisms of neuronal NSW Health $1,000,000

degeneration and regeneration (2005-2010)

(Pollard, Prineas, Banarti and Bennet)

Pathogenisis of inflammatory demyleinating neuropathy National Health & Medical $375,000

(Pollard, Spies and Sutton) (2003-2006)

Role of CD8 T cells in the immunopathology of MS NMSSA $110,000

(Parratt, Pollard, Prineas) (2006-2007)

Equipment Grant National Health & Medical $73,000

(Pollard, Goetz, Hawke) Research Council


Annual Report 22000066 | 2277 |

22000066 AA

tttteenndd

aanncceess

JJaann

FFeebb

MMaarr

AApp

rrMM

aayy

JJuunn

JJuull

AAuugg

SSeepp

OOcctt

NNoovv

DDeecc

TToottaa

ll

Ad

mis

sio

n110

131

142

125

132

137

138

136

134

150

116

117

11,,55

6688

Aud

iolo

gy

98

78

128

90

147

113

103

122

107

115

74

100

11,,22

7755

Auto

nom

ic S

tud

y7

11

99

21

17

10

16

12

15

11

12

115500

Consultation

220

247

392

201

354

219

263

312

206

327

357

246

33,,33

4444

EE

G40

48

68

58

63

67

64

63

65

58

51

65

771100

EE

GA

mb

ula

tory

78

11

10

16

815

12

13

13

11

7113311

EE

G T

ele

mentr

y10

10

16

17

20

16

19

13

12

15

13

11

117722

EM

G34

102

95

67

74

89

74

85

81

97

106

51

995555

EN

G +

VFT

157

147

154

110

219

157

189

152

137

145

167

131

11886655

Evoked

Pote

ntials

55

45

63

42

55

55

65

52

41

57

55

40

662255

I.V.

Thera

py

12

17

16

424

715

611

99

4113344

Neuro

psycholo

gy C

onsult

46

76

53

57

73

40

18

24

22

25

31

18

447733

Seiz

ure

Clin

ic24

72

81

46

112

66

93

89

83

81

67

881144

Vestib

ula

r R

ehab

730

33

89

44

26

63

26

28

31

29

440066

Vestib

ula

r E

valu

ation

105

102

96

80

159

107

131

118

109

98

118

86

11,,33

0099

Ward

Consultation

25

31

32

37

32

35

32

36

41

32

43

31

440077

IInnssttiittuuttee ooff CClliinniiccaall NNeeuurroosscciieenncceess22000066 RReeccoorrdd ooff AAtttteennddaanncceess

Ward

Consultation

40

37

33

29

48

34

33

40

48

31

33

42

444488

Ward

Consultation

40

37

33

29

48

34

33

40

48

31

33

42

444488

Ward

Consultation

40

37

33

29

48

34

33

40

48

31

33

42

444488

Boto

x C

linic

17

32

31

24

28

31

19

34

33

36

32

28

334455

Neuro

surg

ery

Clin

ic38

39

68

41

37

59

56

45

57

42

50

32

556644

Neuro

path

olo

gy

28

30

58

22

45

40

46

52

34

41

39

31

446666

| 2288 | Annual Report 22000066

Please send to: The Nerve Research Foundation, Blackburn Building, D06

University of Sydney NSW 2006.

Tel No: (02) 9351 3385 - Fax No. (02) 9351 4018

All donations over $ 2 are allowable deductions for taxation purposes

I wish to donate $ _________________ to the Nerve Research Foundation.

1. Enclosed is my cheque made payable to the Nerve Research Foundation, or

2. Please debit my: Bankcard MasterCard Visa

Account number: Expiry Date: _____ /_____ /_____

Signature: ________________________________________________________________________________________________________________

Name: ____________________________________________________________________________________________________________________

Address: _________________________________________________________________________________________________________________

________________________________________________________________________ Postcode: _______________________________________

IInnddiivviidduuaallss

Dr R Chow

Mr J Graham

Mr and Mrs Ainsworth

EM and RJ Barnum

CR and CE Hando

L Newman

JL and PA Alston

Dr R Kerr

H Tabrett

P Kiriakos

Mr and Mrs Anderson

J Corney

Douglas Graham Ritchie Bequest

CCoorrppoorraattiioonnssSchering

Biogen IDEC

Serono

WWiitthh ssppeecciiaall tthhaannkkss ttoo oouurr bbeenneeffaaccttoorrss iinn 22000066

We would like to thank the following for contributing to the costs of producing this Annual Report.

EEddiitteedd bbyy: Patricia Armati, Nicholas Jufas.

Website of InterestNational Multiple Sclerosis Society - www.nmss.org

TThhee IInnssttiittuuttee ooff CClliinniiccaall NNeeuurroosscciieenncceessRoyal Prince Alfred Hospital, NSW, Australia. - Tel: (02) 9515 7565

TThhee NNeerrvvee RReesseeaarrcchh FFoouunnddaattiioonnBlackburn Building, D06 - University of Sydney NSW 2006. - Tel: (02) 9351 3385 - Fax: (02) 9351 4018

www.nrf.med.usyd.edu.au

[email protected]

All donations over $2 are allowable deductions for taxation purposes

Annual Report 2006 - Nerve Research Foundation - PDF

Documents

Transcript of Annual Report 2006 - Nerve Research Foundation - PDF