A Novel Pharmacodynamic Assay to Measure Glutaminase Inhibition Following Oral Administration

of CB-839 in Triple Negative Breast Cancer Biopsies Andy MacKinnon, Mark Bennett, Ethan Emberley, Matthew Gross, Julie Janes, Evan Lewis, Alison Pan, Mirna Rodriguez, Peter Shwonek, Taotao Wang, Jinfu Yang, Frances Zhao, Francesco Parlati

Calithera Biosciences, South San Francisco, CA

2014 San Antonio Breast Cancer Symposium -- December 9-13, 2014

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Abstract # P1-08-07

Abstract # P1-08-07: MacKinnon et al. A Novel Pharmacodynamic Assay to Measure Glutaminase Inhibition Following Oral Administration of CB-839 in Triple Negative Breast Cancer Biopsies San Antonio Breast Cancer Symposium -- December 10-13, 2014

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Abstract # P1-08-07: MacKinnon et al. A Novel Pharmacodynamic Assay to Measure Glutaminase Inhibition Following Oral Administration of CB-839 in Triple Negative Breast Cancer Biopsies San Antonio Breast Cancer Symposium -- December 10-13, 2014

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Abstract # P1-08-07: MacKinnon et al. A Novel Pharmacodynamic Assay to Measure Glutaminase Inhibition Following Oral Administration of CB-839 in Triple Negative Breast Cancer Biopsies San Antonio Breast Cancer Symposium -- December 10-13, 2014

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Abstract # P1-08-07: MacKinnon et al. A Novel Pharmacodynamic Assay to Measure Glutaminase Inhibition Following Oral Administration of CB-839 in Triple Negative Breast Cancer Biopsies San Antonio Breast Cancer Symposium -- December 10-13, 2014

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Abstract # P1-08-07: MacKinnon et al. A Novel Pharmacodynamic Assay to Measure Glutaminase Inhibition Following Oral Administration of CB-839 in Triple Negative Breast Cancer Biopsies San Antonio Breast Cancer Symposium -- December 10-13, 2014

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Abstract # P1-08-07: MacKinnon et al. A Novel Pharmacodynamic Assay to Measure Glutaminase Inhibition Following Oral Administration of CB-839 in Triple Negative Breast Cancer Biopsies San Antonio Breast Cancer Symposium -- December 10-13, 2014

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Abstract # P1-08-07: MacKinnon et al. A Novel Pharmacodynamic Assay to Measure Glutaminase Inhibition Following Oral Administration of CB-839 in Triple Negative Breast Cancer Biopsies San Antonio Breast Cancer Symposium -- December 10-13, 2014

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Abstract # P1-08-07: MacKinnon et al. A Novel Pharmacodynamic Assay to Measure Glutaminase Inhibition Following Oral Administration of CB-839 in Triple Negative Breast Cancer Biopsies San Antonio Breast Cancer Symposium -- December 10-13, 2014

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Abstract # P1-08-07: MacKinnon et al. A Novel Pharmacodynamic Assay to Measure Glutaminase Inhibition Following Oral Administration of CB-839 in Triple Negative Breast Cancer Biopsies San Antonio Breast Cancer Symposium -- December 10-13, 2014

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Abstract # P1-08-07: MacKinnon et al. A Novel Pharmacodynamic Assay to Measure Glutaminase Inhibition Following Oral Administration of CB-839 in Triple Negative Breast Cancer Biopsies San Antonio Breast Cancer Symposium -- December 10-13, 2014

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Abstract # P1-08-07: MacKinnon et al. A Novel Pharmacodynamic Assay to Measure Glutaminase Inhibition Following Oral Administration of CB-839 in Triple Negative Breast Cancer Biopsies San Antonio Breast Cancer Symposium -- December 10-13, 2014